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Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 24 - 24
1 Mar 2008
Moran M Walmsley P Gray A Brenkel I
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There is little evidence describing the influence of body mass index on the outcome of Total Hip Replacement (THR). There are concerns that an increasing BMI may lead to increased blood loss, infection and venous thromboembolism. 800 consecutive patients undergoing primary cemented THR were followed for a minimum of 18 months. The Harris Hip Score (HHS) and SF-36 were recorded pre-operatively and at 6 and 18 months post-operatively. In addition other significant events were noted, namely death, dislocation, re-operation, superficial and deep infection and blood loss. Multiple regression analysis was performed to identify whether BMI was an independently significant predictor of the outcome of THR.

No relationship was seen between the BMI of an individual and the development of any of the complications noted. The HHS was seen to increase dramatically post-operatively in all patients. BMI did predict for a lower HHS at 6 and 18 months, and a lower physical functioning component of the SF-36 at 18 months. This effect was small when compared with the overall improvements in these scores.

Conclusion: THR provides good symptomatic relief irrespective of BMI. On the basis of this study we can find no justification for withholding THR solely on the grounds of BMI.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 415 - 415
1 Oct 2006
Moran M Heisel C Rupp R Breusch S
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Aims: To evaluate the function of cement restrictors beyond the femoral isthmus.

Introduction: Pressurisation of cement is key to achieving good cement-bone interdigitation in Total Hip Replacement. During insertion of the femoral stem, pressures of up to 1000kPa may be generated. To maintain pressurisation the medullary canal must be sealed distally using a cement restrictor. As a secondary effect, cement restrictors also prevent excess injection of cement into the medullary canal. To fulfil these functions the cement restrictor must remain stable in the femoral canal.

Methods: Five different cement restrictors were evaluated, namely the Exeter Cement Plug (Stryker, UK), Biostop (De Puy, UK), Hardinge (De Puy, UK), Rex CementStop (A-One-Medical, Netherlands) and a preinjected cement plug (Surgical Simplex, Stryker, UK). The restrictor was deployed in a sawbone that had been rasped to produce a distal flare. Low viscosity bone cement (Surgical Simplex, Stryker, UK) was injected and pressurised using a custom made cement ram connected to a 10bar pressurised air supply. An electronically controlled pressure valve increased the pressure in the cement. Pressure in the cement was measured using a pressure transducer. A linear variable displacement transducer was used to measure movement of the cement restrictor. Leakage of cement around the restrictor was also recorded. Activation of the pressure valve and recording of measurements was controlled by a customised computer package.

Results: The Rex CementStop withstood the greatest pressures (mean 565.8kPa). This was a significantly greater pressure than any of the other cement restrictors (p= 0.027). Pre-injected cement plugs were able to resist the next highest pressures (mean 350.4kPa). They did not displace but leaked cement and were technically difficult to deliver in the distal femur. Cement restrictors that function well above the isthmus were ineffective (Biostop mean 118.7kPa) or could not be deployed below the isthmus (Exeter). The Hardinge cement restrictor recorded a mean 162.3kPa.

Discussion: It is important for a surgeon to consider where the cement restrictor will sit in the femur during pre-operative templating in Total Hip Replacement. When the cement restrictor is going to be deployed beyond the femoral isthmus, an alternate method of cement restriction may need to be used. Universal sized plugs (e.g. Hardinge) function poorly in this situation. Press-fit plugs such as Biostop and Exeter have been previously shown to allow the generation of high pressures in bone cement when sited above the femoral isthmus or in stove pipe femurs. However their function is severely compromised when inserted past the femoral isthmus. Pre-injected cement plugs are variable in efficacy. The expandable Rex CementStop was simple to use and reliably occluded the femur, allowing the highest pressures to be generated.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 48 - 48
1 Mar 2006
Gray A Walmsley P Moran M Brenkel I
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This prospective study aimed to establish if octogenarians undergoing primary hip arthroplasty experienced a similar clinical outcome and complication rate as younger patients.

A total of 585 patients were recruited over a 4-year period. Patients aged 70–79 years and 80–89 years (octogenarians) were placed into separate groups.

Harris hip and SF-36 scores were obtained before and at 6 and 18 months following surgery. Other measurements included: blood loss; blood transfusion rate; wound infection; thromboembolism; dislocation and 90-day mortality.

Statistical analysis included a two-sample t-test and chi-squared analysis with Yates correction to compare results in each group. Analysis of covariance was used to calculate confidence limits for the effect of age group on Harris hip and SF-36 scores at 6 and 18 months after adjusting for levels recorded prior to surgery. Multiple logistic regression analysis was performed to determine any predictive factors for a noted difference in blood transfusion rates between patient cohorts.

A significantly better (P=0.019) improvement in mean Harris Hip score (SD) was seen 18-months after surgery in the younger cohort (43.4 (13.8) compared to 39.8 (10.6)). Length of hospital stay was longer (P< 0.001) in the octogenarians (12.9 (SD 7.0) days versus 10.1 (SD 4.7)) with a higher blood transfusion rate of 40% compared to 28% (P = 0.009). Lower pre-operative haemoglobin levels strongly correlated with the need for blood transfusion. No significant differences in infection, dislocation, thromboembolism or 90-day mortality rates were found.

Conclusions: Octogenarians are more likely to require blood transfusion and a longer hospital stay, with less improvement in clinical outcome at 18 months after primary hip arthroplasty.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 155 - 155
1 Apr 2005
Walmsley P Gray A Moran M Brenkel I
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Aim: To assess the results of total knee arthroplasty in a cohort of patients aged 80–89 years and compare them to a similar group of patients aged 70–79

Introduction: With the average age of the population steadily rising, more patients are likely to present with arthritis over 80 years of age. The benefits of Total Knee Arthroplasty (TKA) in the treatment of osteoarthritis are widely known, but there are few studies which examine the results of TKA in octogenarians.

Methods: Data was collected prospectively from 1995–2002 on 115 patients undergoing TKA aged 80–89 years and compared to 411 patients who were aged 70–79 undergoing TKA during the same period. Patients undergoing unicompartmental, revision or bilateral TKA were excluded. Patients were seen pre-operatively and scores for SF-36, American Knee Society (AKS) score and haemoglobin were taken along with demographic data. The outcome measurements used were SF-36 score, AKS score, blood loss, length of stay, mortality and post-operative complications. These were collected during the first week post-surgery and at 6 and 18 months post-surgery.

Results: Both groups showed significant increases in AKS score at 6 months, (54.17 and 54.45, both p=0.0001). We continued to see improvement of the AKS score up to 18 months (mean 85.38 and 85.12, p= 0.55) with no significant difference between the two groups. Patients over 80 had lower pre-op Haemoglobin (Hb) (mean 13.56 and 12.23, p=0.0001) but experienced the same Hb drop post-procedure. There was no difference in postoperative complications, but the length of stay (8.3 days and 13.9 days, p=0.0001) and mortality rate (0.7% and 5%, p=0.0001) were higher.

Conclusions: Our early results show that TKA can be beneficial to patients over 80 years in terms of mobility and independence, but they have a longer in-patient hospital stay and attract a slightly higher mortality risk at 90 days.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 75 - 75
1 Jan 2004
Gray A Walmsley P Moran M Brenkel I
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Background: Previous studies have reported mixed findings with regards to post operative complication rates and overall outcome in elderly patients undergoing total hip arthroplasty. The aim of this study was a prospective comparison of physical and functional outcome measurements following primary hip arthroplasty in patients aged 80–90 years to those aged 70–79.

Methods: Data was prospectively recorded from 1998–2002. 144 patients aged 80–90 years underwent primary hip arthroplasty compared to 441 aged 70–79. A pre-operative Harris Hip Score was obtained on all patients and a standardized follow up regimen was used for assessment at 6, 18 and 36 months post surgery. Data collection included: intraoperative blood loss; post operative transfusion rate; incidence of wound infection, DVT and pulmonary embolus; dislocation and mortality rates. Statistical analysis involved two-sample t-test and chi-squared with Yates correction.

Results: Pre-operative Harris Hip Scores were 41.6 (SD 11.2) in the younger cohort and 39.3 (SD 12.4) in the octogenarian (P = 0.04). This score had improved by 39.3 and 38.1 points respectively (P = 0.5) at 6 months; 42.3 and 37.7 at 18 months (P = 0.02); 43.4 and 39.8 at 36 months (P = 0.24).

The mortality rate at 3 months following surgery was 4% in our octogenarian group compared to 1% (P=0.02). Mean length of hospital stay was significantly (P< 0.001) longer at 12.9 (SD 7.0) days compared to 10.1 (SD 4.7). The transfusion rate in our octogenarian group was 40% compared to 28% (P = 0.009). The incidence of deep infection was 1.4% in the older group compared to 0.5% (NS). Each group had a dislocation rate of 1%. and an incidence of DVT and pulmonary embolus that was comparable.

Discussion: Total hip arthroplasty can be performed safely in octogenarians with excellent relief of pain and improved function.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 81 - 81
1 Jan 2004
Moran M Soon YL Walmsley P Brenkel IJ
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Introduction: There is little published on the outcome of orthopaedic surgery performed by surgeons in training. The individual results of orthopaedic units and consultants are coming under increasing scrutiny. There may be concerns that trainee performed THR will negatively impact on these figures. This study compares the outcome of THR’s performed by consultants and supervised trainees.

Methods: Data was prospectively collected on 139 THR’s carried out by supervised specialist registrars (years 1 to 4) and 397 THR’s carried out by consultants. The Harris Hip Score (HHS) was used as the primary outcome measure and scores were taken at 7days pre-operatively, 6 and 18 months post-operatively. In addition data on co-morbidity, blood loss, transfusion requirements, re-operation, dislocation and death were recorded. Radiographs of 110 trainee and 110 consultant performed THR’s were compared at 6 months. Acetabular anteversion and abduction and femoral orientation were assessed on lateral and AP films. Cementation was judged using methods described by Hodgkinson and Barrack.

Results: Blood loss, transfusion requirement, dislocation, revision, deep infection and the HHS at 6 and 18 months showed no statistically significant difference between trainee and consultant (all p< 0.05). Component orientation and cementation quality again showed no significant difference (p< 0.05).

Discussion: This paper reveals no difference in the short term results of THR performed by consultants and supervised trainees. Our results show that quality can be maintained whilst training juniors to operate.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 81 - 81
1 Jan 2004
Moran M Walmsley P Brenkel IJ
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Introduction: There is little evidence describing the influence of Body Mass Index (BMI) on the outcome of Total Hip Replacement (THR). There are concerns that an increasing BMI may increase complication rates such as superficial and deep infection, blood loss, operation time and aseptic loosening. There is evidence that obese patients receive good symptomatic relief from THR and so it is important that the advisability of surgery is made on good evidence.

Methods: 800 patients undergoing primary Charnley total hip replacement were followed prospectively for a minimum of 18 months. The Harris Hip Score (HHS) and SF-36 were recorded pre-operatively and at 6 and 18 months post-operatively. Other significant events were noted, namely death, dislocation, re-operation, superficial and deep infection and blood loss. Stepwise multiple regression analysis was performed to identify whether BMI was an independently significant predictor of the outcome of THR.

Results: The mean age of patients was 68 years, with 61% females. At 18 months 31 patients (39 hips) had died. There were 15 re-operations, 13 dislocations and 7 deep infections.

No relationship was seen between the BMI of an individual and the development of post-operative complications. The HHS was seen to increase dramatically postoperatively in all patients (mean 43 points at 18 months). BMI did predict for a lower HHS at 6 and 18 months and a lower physical functioning score on the SF-36.

Discussion: THR produces a significant improvement in symptoms in patients, irrespective of BMI. An increasing BMI does not result in an increase in the early complication rate following THR. There is a reduction in the HHS and physical function component of SF-36 with increasing BMI, although this effect is small. On the basis of this study we do not think that THR should be withheld solely on the grounds of BMI.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 171 - 171
1 Feb 2003
Moran M Khan A Sochart D Andrew G
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This study was performed to evaluate the pre-operative concerns of patients undergoing total knee or hip replacement surgery.

A cross-sectional study of 370 patients was performed. The patients completed a postal questionnaire on 29 concerns, each rated on a scale of 1 (not concerned) to 4 (very concerned). SF-12 and Oxford knee or hip scores were also calculated. Analysis was carried out using chi-squared test.

217 questionnaires were returned. The results showed that the greatest concern for patients was cancellation of their operation. This was followed by failure of the operation to reduce pain, loss of a limb and joint infection. Concerns regarding scar problems, nursing care and preoperative tests were the lowest.

Women showed statistically significant greater concerns in 9 areas. Younger patients (age< 65) showed increased concerns in 8 areas. Patients who had previously undergone joint replacement were less concerned than those who had not had previous lower limb joint replacements for 6 responses. They showed increased concern in 2 areas, nursing care and hospital food. Those undergoing total hip replacement were more concerned about dislocation, dressing and returning to work (all p< 0.05). The mean Oxford Knee or Hip Score was 42.96 and 45.12 respectively (scale 12–60, 60 being most severe symptoms). The mean SF-12 scores were 41.14 for the mental component and 28.70 for the physical component score (scale 0–100, 100 representing greatest level of good health).

The mean level of concern is low at 1.9 (scale 1 to 4). It is encouraging that patients who have had a previous joint replacement are generally less concerned. Possible reasons for increased concerns amongst women and younger patients are discussed. SF-12 and Oxford Knee/Hip Scores are comparable with other studies.

In conclusion, this study provides useful information for the preoperative counselling of patients and the production of pre-operative literature.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 65 - 65
1 Jan 2003
Moran M Khan A Sochart D Andrew G
Full Access

This study was performed to evaluate the pre-operative concerns of patients undergoing total knee or hip replacement surgery.

A cross-sectional study of 370 patients was performed. The patients completed a postal questionnaire on 29 concerns, each rated on a scale of 1 (not concerned) to 4 (very concerned). SF-12 and Oxford knee or hip scores were also calculated. Analysis was carried out using chi-squared tests on SPSS.

217 questionnaires were returned. The results showed that the greatest concern for patients was cancellation of their operation. This was followed by failure of the operation to reduce pain, loss of a limb and joint infection. Concerns regarding scar problems, nursing care and preoperative tests were the lowest.

Women showed statistically significant greater concerns in 9 areas. Younger patients (age< 65) showed increased concerns in 8 areas. Patients who had previously undergone joint replacement were less concerned than those who had not had previous lower limb joint replacements for 6 responses. They showed increased concern in 2 areas, nursing care and hospital food. Those undergoing total hip replacement were more concerned about dislocation, dressing and returning to work (all p< 0.05). The mean Oxford Knee or Hip Score was 42.96 and 45.12 respectively (scale 12–60, 60 being most severe symptoms). The mean SF-12 scores were 41.14 for the mental component and 28.70 for the physical component score (scale 0–100, 100 representing greatest level of good health).

The mean level of concern is low at 1.9 (scale 1 to 4). It is encouraging that patients who have had a previous joint replacement are generally less concerned. Possible reasons for increased concerns amongst women and younger patients are discussed. SF-12 and Oxford Knee/Hip Scores are comparable with other studies.

In conclusion, this study provides useful information for the preoperative counselling of patients, production of preoperative literature and for improving the service we offer to our patients.