Inspired by mussel-adhesion phenomena in nature can integrate inorganic hydroxyapatite crystals within versatile materials. This is a simple, aqueous, two-step functionalization approach, called polydopamine-assisted hydroxyapatite formation (pHAF), that consists of i) the chemical activation of material surfaces via polydopamine coating and ii) the growth of hydroxyapatite in a simulated body fluid (SBF). We presumed polydopamine coating on the surface of titanium alloy would improve the ability of cementless stems to osseointegrate. We therefore compared the in vitro ability of cells to adhere to polydopamine coated Ti alloy and machined Ti alloy. We performed energy-dispersive x-ray spectroscopy and scanned electron microscopy investigations to assess the structure and morphology of the surfaces. Biologic and morphologic responses to osteoblast cell lines (MC3T-E1) were then examined by measuring cell proliferation, cell differentiation (alkaline phosphatase activity), and avb3 integrin.Introduction
Method
Surgical dislocation is useful for assessing and treating proximal femoral hip deformities. Legg-Calv Perthes disease (LCPD) causes proximal femoral growth deformity, resulting in reduced femoral head-neck offset and femoracetabular incongruity. The purpose of this study was to demonstrate the efficacy and report the short-term results of surgical hip dislocation for the treatment of adolescents with healed LCPD. This retrospective review included 29 adolescents [19 males and 10 females, age 17 (range nine-35)] with LCPD, who underwent surgical hip dislocation between January 2001 and December 2009. All subjects had a clear diagnosis of LCPD, pre and postoperative WOMAC scores and at least one year of clinical and radiographic follow up. In addition to surgical dislocation, all patients underwent femoral head-neck osteoplasty, 21 underwent relative femoral neck lengthening and trochanteric transfer, 12 underwent intertrochanteric osteotomy and seven had labral debridement. The average follow-up was three years from the time of surgical intervention.Purpose
Method
