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Bone & Joint Research
Vol. 11, Issue 12 | Pages 843 - 853
1 Dec 2022
The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection
Cai Y Huang C Chen X Chen Y Huang Z Zhang C Zhang W Fang X
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Aims

This study aimed to explore the role of small colony variants (SCVs) of Staphylococcus aureus in intraosseous invasion and colonization in patients with periprosthetic joint infection (PJI).

Methods

A PJI diagnosis was made according to the MusculoSkeletal Infection Society (MSIS) for PJI. Bone and tissue samples were collected intraoperatively and the intracellular invasion and intraosseous colonization were detected. Transcriptomics of PJI samples were analyzed and verified by polymerase chain reaction (PCR).