Abstract
Aims
To evaluate the incidence, patient demographics, primary tumour characteristics and treatment modalities of patients with radiation induced soft tissue sarcoma (RISTS) presenting to the East Midlands Sarcoma Service at Nottingham City Hospital.
Methods
All consecutive patients with histologically proven RISTS were identified from our pathology database. Case notes were retrospectively reviewed to identify patient demographics, oncological features and treatment outcome.
Results
From 1998 to 2011, 24 patients were identified to have RISTS. 17 were female, 7 male. The mean age at time of diagnosis is 67 years (range 40–85 years). The average latency period is 12.8 years (range 1–50). The most common primary oncological diagnosis were breast carcinoma 11 (11, 45.8%) and endometrial carcinoma and testicular tumours (both 3, 12.5%). The sarcoma subtypes were 9 angiosarcomas (37.5%), 6 pleomorphic sarcomas (29.1%), 3 leiomyosarcomas (12.5%), 2 myofibroblastic sarcomas (8.4%), 1 MPNST (4.2%) 1 soft-tissue osteosarcoma (4.2%) 1 dedifferentiated liposarcoma (4.2%) and 1 myxoid liposarcoma (4.2%). At the time of this study, 8 patients died of disease, 13 were alive and disease free, 1 alive with disease, 1 discharged from follow-up disease free and 1 lost to follow-up
Discussion
RISTS are rare sarcomas with poor prognosis. An aggressive surgical approach with multi-disciplinary team involvement is of paramount importance.
