Abstract
The optimal management of patients with the diagnosis of a spinal epidural abscess (SEA) remains controversial. The purpose of this study was to describe the clinical characteristics of patients presenting with spontaneous SEA and to correlate presentation and treatment with clinical and neurological outcome.
A retrospective review of the medical records and radiology of patients with a diagnosis of SEA, treated between September 2003 and December 2010, at a tertiary referral hospital was performed. A total of 46 patients were identified including 27 males and 19 females. Mean age was 61 years (range, 30 – 86 years). At presentation, all patients had axial pain and 67% had a neurological deficit, out of which one third had paraplegia or quadriplegia. 32% patients were febrile. Diabetes was the most common risk factor (30%) followed by malignancy (17%), intravenous drug use (6%) and alcoholism (2%).
Organisms were cultured in 44 patients with Methicillin Sensitive Staphylococcus Aureus most common (68%), followed by Methicillin Resistant Staphylococcus Aureus (14%). The epidural abscess was located in the lumbar spine in 24 patients, thoracic spine in 11 patients and cervical spine in 11 patients. 61% of patients had a concurrent source of septic focus on presentation, including psoas abscess (24%), facet joint septic arthritis (15%), pneumonia (11%), infective endocarditis (7%) and urosepsis (4%). 26% of patients were treated non-operatively, with computed tomography-guided aspiration and/or intravenous antibiotics based on cultures, whereas 74% underwent surgical decompression with or without fusion in combination with antibiotics. The mean inpatient hospital stay was 42 days (range, 2 – 742 days) and 34% of patients required an average of 40 days of Intensive Care Unit admission. At time discharge from hospital, of the patients managed nonoperatively, 33% had improved neurological function, 17% had worsened neurological function, 17% died and data was unavailable in 33%. Of the patients treated with surgery, 74% had improved neurological function, 6% remained unchanged, 6% had worsened neurologic function, 6% died and data was unavailable in 9% at time of discharge.
SEA remains a severe condition associated with multiple septic foci and significant morbidity. Surgical decompression combined with antibiotics is associated with superior neurologic recovery compared with non-operative management, however a significant proportion of patients still deteriorate or die. Early diagnosis and management may prevent or reduce permanent neurologic deficit.
