Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation

S. Bajada; P. E. Harrison; B. A. Ashton; V. N. Cassar-Pullicino; N. Ashammakhi; J. B. Richardson

doi:10.1302/0301-620x.89b10.19103

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Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation

S. Bajada
P. E. Harrison
B. A. Ashton
V. N. Cassar-Pullicino
N. Ashammakhi
J. B. Richardson

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Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation

Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N, Richardson JB. Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br. 2007;89-B(10):1382-1386. doi:10.1302/0301-620X.89B10.19103

Bajada, S., et al. “Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation.” The Journal of Bone & Joint Surgery British Volume, vol. 89-B, no. 10, 2007, pp. 1382-1386., https://doi.org/10.1302/0301-620X.89B10.19103

Bajada, S., Harrison, P. E., Ashton, B. A., Cassar-Pullicino, V. N., Ashammakhi, N., & Richardson, J. B. (2007). Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. The Journal of Bone & Joint Surgery British Volume, 89-B(10), 1382-1386. https://doi.org/10.1302/0301-620X.89B10.19103

Bajada, S., Harrison, P. E., Ashton, B. A., Cassar-Pullicino, V. N., Ashammakhi, N. and Richardson, J. B. (2007) “Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation.” The Journal of Bone & Joint Surgery British Volume, 89-B(10), pp. 1382-1386. Available at: https://doi.org/10.1302/0301-620X.89B10.19103

Bajada, S., P. E. Harrison, B. A. Ashton, V. N. Cassar-Pullicino, N. Ashammakhi, and J. B. Richardson. “Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation.” The Journal of Bone & Joint Surgery British Volume 89-B, no. 10 (2007): 1382-1386. https://doi.org/10.1302/0301-620X.89B10.19103

Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N, Richardson JB. Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br. 2007 Oct 1;89-B(10):1382-1386. https://doi.org/10.1302/0301-620X.89B10.19103

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Abstract

Successful healing of a nine-year tibial nonunion resistant to six previous surgical procedures was achieved by tissue engineering. We used autologous bone marrow stromal cells (BMSCs) expanded to 5 × 10⁶ cells after three weeks’ tissue culture. Calcium sulphate (CaSO₄) in pellet form was combined with these cells at operation. The nonunion was clinically and radiologically healed two months after implantation.

This is the description of on healing of a long-standing tibial nonunion by tissue engineering. The successful combination of BMSCs and CaSO₄ has not to our knowledge been reported in a clinical setting.

Correspondence should be sent to Dr S. Bajada; e-mail: stefan_bajada@yahoo.com

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