4.P.33 SUBCLINIC LIVER DYSFUNCTION IN CHILDREN WITH SARCOMAS OF BONES AND SOFT TISSUE

Abstract

Subclinic liver dysfunctions (SLD) wildly spread among adult oncology patients and can negatively influence to results of some oncology patients treatment. But information concerning same problem in children is remain lack.

The purpose of this investigation was the determination of SLD spreading among children with sarcomas of bone and soft tissues and estimation its clinical significance.

Materials and methods: 200 children with sarcomas of bones and soft tissues were involved in the observation (136 boys and 64 girls) in age groups: 2–10 years – 86 and older 10 years – 114. All children were examined with the help of clinic and laboratory methods including biochemical, serologic and immunologic testing of the blood.

Results and discussion: Results obtained if the investigation demonstrated that different degree of the SLD was widely spread among children with sarcomas – biochemical signs of SLD were detected at 26.0% children. Frequency and degree of severity of SLD increased parallel with increasing the clinical stages of sarcomas.

Serological markers of infections caused hepatitis B and C viruses in all children had biochemical signs of SLD were detected in several times frequently than in all children had no above mentioned signs of subclinic hepatopathy.

Presence of SLD signs in children with sarcomas was accompanied with more expressed depression of immunologic reactivity including natural antitumor resistance estimated on the base of natural killer cells’ cytotoxicity.

Besides, presence of biochemical signs of SLD in children with sarcomas was accompanied with more frequent and expressed side-effects of chemotherapy and lower effect of treatment of those children.

Conclusions: 1. SLD spread among children with sarcoma as like as among adult oncology patients. 2. Presence of SLD children with sarcomas has important clinical significance.