1.P.03 TREATMENT OF LOCALIZED EWING’S FAMILY TUMORS OF THE RIBS IN CHILDHOOD WITH INTENSIVE MULTIMODAL THERAPY: SINGLE CENTER EXPIRIENCE

Abstract

We analyzed the results of the intensive multimodality therapy of children with localized Ewing’s family tumors of the ribs (EFTR). 22 patients with localized EFTR were treated in our institute between 1996 and 2006. The age is ranged from 4 to 15 years. 10 patients were male, 12 – female. Eight patients had a classic Ewing sarcoma(ES), 14 – PNET. The high risk criterion was tumor volume over 100 ml. The treatment plan included intensive induction chemotherapy (adapted to risk group) consist of 5 courses (1, 3, 5 courses – vincristine, adriamicin, cyclophosphamide, 2, 4 courses – ifosfamide and etoposide) and local control (surgery and radiotherapy), and consolidation with or 5 courses standard therapy or high-dose chemotherapy with stem-cell rescue. 4 patients underwent high-dose chemotherapy, 18 – consolidation with standard arm.

Two patients died from complications of chemotherapy, 20 patients completed the treatment. 5-year overall survival (OAL) of patients was 70±10,4%, 5-year event-free survival (EFS) was 58,9±11,4%. We conclude that Ewing’s family tumors are the most common tumors of ribs in childhood. Improved EFS requires more aggressive systemic chemotherapy and surgery (removing of entire affected ribs). Long-term survival is possible, even for high risk patients.