Abstract
Introduction: Osteomyelitis remains a rare diagnosis and a difficult one to make. Acute osteomyelitis in the context of sickle cell disease remains the subject of some controversy, particularly with regard to aetiology. It is known that Salmonella species are more commonly the cause of acute bone infection in sickle cell patients than in patients with normal red blood cell morphology, but there has long been an argument as to whether Staphylococcus Aureus is in fact still the most common bacterial cause overall in this patient group, as it is in the population overall. We present a consecutive case series of 12 cases of acute osteomyelitis in paediatric patients in East London over the last twenty years.
Materials and Methods: Retrospective review of 12 consecutive cases. Medical Notes along with microbiology records and radiographic results were cross referenced with a paediatric sickle cell data base held by the haematology department.
Results: 10 of the 12cases had an organism isolated from either blood or bone culture(s). Salmonella spp in cases, S. Aureus in 2 cases and Pseudomonas in the remaining case
Discussion: The question of causative organism is complicated by the fact that most case series’ have bracketed adults and children together, and that conflicting conclusions have resulted from quite small, usually retrospective studies at different times and from different parts of the world – Nigeria, Saudi Arabia and the United States of America. It appears that endemicity is a result of many factors including age; race and socioeconomic factors all play a role.
Conclusion: These results reveal that in our paediatric sickle cell population, Salmonella infection occurs ore commonly than Staphylococcus.
Correspondence should be addressed to BSCOS c/o BOA, at the Royal College of Surgeons, 35–43 Lincoln’s Inn Fields, London, WC2A 3PE, England.
