OUR EXPERIENCE IN RECONSTRUCTIVE SURGERY USING 80%TCP/20%HA (BONESAVE™) LIKE SYNTHETIC BONE SUBSTITUTE

Abstract

Loss of bone stock resulting from wear particle-induced osteolysis may compromise the stability and osteoin-tegration of arthroplasty implants. Usually allogeneic corticocancellous bone is used around an implant to fill the defects, but because of the safety and availability of these grafts, the use of synthetic substitute of bone is becoming everyday frequently. BoneSave™ is an osteo-conductive biomaterial prevalently used in reconstructive surgery but it can be used to fill every bone defects or in traumatology like adjuvant of an osteosynthesis. The particles of BoneSave™ (2–4 mm or 4–6 mm) are made of tricalcium phosphate 80% and hydroxyapatite 20%, they have a superficial porosity of 50% (range 10–400 mm). Usually the osteointegration happens after 2–3 years. Recently studies have described that the mixture of 80% TCP/20% HA with human mesenchymal stem cells induced bone formation in vivo faster than the other formulations of the same elements, In vitro studies also demonstrated the expression of osteocalcin. The mixture of TCP/HA with bone-marrow aspiration could be useful if human stem cells are not available. Orthopaedic and traumatology cases will be shown where the use of Bone-Save™ has lead to good clinical and radiological results after a follow-up of 24 months.