Abstract
A better understanding of the pathophysiology of rheumatoid arthritis has led to important and innovative approaches to its treatment In the case of confirmed diagnosis the recommended gold standard is to give methotrexat, possibly in combination with corticosteroids. If disease activity cannot be controlled, other basic therapies, possibly in combination with or as biologic DMARDs (Diseases modifying drugs) are prescribed. The main emphasis here is placed on TNF-Alpha blocker and drugs that inhibit Interleukin-1. New drugs such as anti-CTLA4-Ig and anti-CD20 (Rituximab) aim to influence the activation of T- and B-cells. Management is supplemented by educating the patient, physiotherapy and ergotherapy as well as specific surgical intervention, as required.
Correspondence should be addressed to ERASS Office, Schulthess Klinik, Lengghalde 2, CH-8008 ZURICH, Switzerland.
