Abstract
Purpose: The purpose of our study is to estimate the effectiveness of Parecoxib in the post surgical analgesia in the fractures of the hip joint in comparison with the usage of the combination of Diclofenac ant Pethidine
Material and methods: We have carried out a prospective randomized clinical study, during the period January 2003-July 2004, on 90 patients were operated with fractures of the hip joint. We examined two similar groups of patients concerning the age, the type of fracture and the type of anaesthesia. In group A, consisting of 35 patients, we provided 40 mg of Parecoxib i.v., as postsurgical analgesia, twice a day and in Group B, of 55 patients, we provided the combination of Diclofenac 75mg i.m. twice a day and Pethidine i.m. in case of persisting pain.
The intensity of pain was estimated by the Pain Intensity Scale ( PIS ).
Results: In Group A the PIS was 2.5 ± 0.8, and none of the patients needed supplementary analgesic. In Group B the PIS was 3.2 ± 0.8 and 21 (38.3%) patients needed supplementary analgesics (Pethidine).
In the use of Parecoxib no side effects were noticed (decrease BP, vomiting etc).
Conclusion: Parecoxib is more effective in the post surgical analgesia than Diclofenac and Pethidine in the fractures of the hip joint. It is easier to administer (i.v) and is also seems to be safe (no side effects were noticed). Therefore, we suggest that it should be the drug of choice in the post surgical analgesia of the fractures of the hip joint.
Theses abstracts were prepared by Professor Roger Lemaire. Correspondence should be addressed to EFORT Central Office, Freihofstrasse 22, CH-8700 Küsnacht, Switzerland.
