PERIPHERAL ANEURYSMAL BONE CYST: DIAGNOSTIC AND THERAPEUTIC APPROACH IN 48 CASES

Abstract

Purpose: Aneurysmal bone cyst is a benign osteodystrophic pseudotumor. It can occur as a primary lesion or develop on a pre-existing lesion. The etiopathogenesis, diagnosis and treatment remain subjects of interest.

Material and methods: For this retrospective analysis, we collected 48 peripheral aneurysmal bone cysts over a 27-year period. Most cysts occurred in children, adolescents, or young adults, with a slight female predominance. Imaging included standard x-rays, computed tomography, and for the more recent cases magnetic resonance imaging (MRI). MRI provided new imaging features increasing diagnostic accuracy. Second readings of histology slides enabled establishment of the correct diagnosis in certain cases but differential diagnosis was established only with benign tumours. Surgical treatment predominated. Other treatments included curettage-filling with cancellous bone, resection, resection-reconstruction,curettage-filling with cement. Adjuvant treatments mainly involved use of calcitonin. Therapeutic abstention with surveillance confirmed the possibility of spontaneous regression after biopsy. Curettage-filling with cancellous bone was performed in 58% of cases, giving an Enneking function score of 95.7%.

Results: We reviewed outcome at mean 7 years follow-up. There were four recurrent cysts and the mean global Enneking score was 95%. Our series showed the several methods can be used for the treatment of aneurysmal bone cysts, the indication taking into consideration the patient’s age, the location of the lesion and is progression. We propose a therapeutic schema. The role of calcitonin remains to be determined.

Conclusion: The diagnosis of bone cysts requires a close collaboration between the surgeon, the radiologist, and the pathologist. The indication for surgery must be made case by case to achieve cure without sequelae.