Abstract
A large series of animal experiments in goats was performed in relatevely simple bone chamber models and in very realistic loaded pre-clinical models. In this paper the focuss is on two experiments. In exp 1 we analysed the effect of rinsing of allograft bone on bone ingrowth into the bone induction chamber. We found that rinsing improves the ingrowth capacity to a level that is comparable to that of autologous bone. In experiment 2 we analysed the effect of two different reconstruction methods, e.g., a mesh or a strut graft, on the revascularization of impacted allograft bone in a femoral reconstruction. We found that new vessels can enter the impacted bone through the mesh and that this promotes an early revascularization of the bone graft.
In patients we analysed 24 biopsies of 20 patients and quantitated the amount of non-incorporated graft (remnants of original material), graft in the process of incorporation, incorporated graft (=new bone) and fibrous tissue. With increasng follow up peripods after the revision operation the amount of normal bone increased upto ca 90%. The remaining 10% consists of non-incorpated bone and fibrous tissue.
Theses abstracts were prepared by Professor Dr. Frantz Langlais. Correspondence should be addressed to him at EFORT Central Office, Freihofstrasse 22, CH-8700 Küsnacht, Switzerland.
