BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS

H. M. Van Der Vis; R. K. Marti; W. Tigchelaar; H. M. Schüller; C. J. F. Van Noorden

doi:10.1302/0301-620X.79B5.0790837

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BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS

H. M. Van Der Vis
R. K. Marti
W. Tigchelaar
H. M. Schüller
C. J. F. Van Noorden

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BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS

Van Der Vis HM, Marti RK, Tigchelaar W, Schüller HM, Van Noorden CJF. BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS. J Bone Joint Surg Br. 1997;79-B(5):837-843. doi:10.1302/0301-620X.79B5.0790837

Van Der Vis, H. M., et al. “BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS.” The Journal of Bone & Joint Surgery British Volume, vol. 79-B, no. 5, 1997, pp. 837-843., https://doi.org/10.1302/0301-620X.79B5.0790837

Van Der Vis, H. M., Marti, R. K., Tigchelaar, W., Schüller, H. M., & Van Noorden, C. J. F. (1997). BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS. The Journal of Bone & Joint Surgery British Volume, 79-B(5), 837-843. https://doi.org/10.1302/0301-620X.79B5.0790837

Van Der Vis, H. M., Marti, R. K., Tigchelaar, W., Schüller, H. M. and Van Noorden, C. J. F. (1997) “BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS.” The Journal of Bone & Joint Surgery British Volume, 79-B(5), pp. 837-843. Available at: https://doi.org/10.1302/0301-620X.79B5.0790837

Van Der Vis, H. M., R. K. Marti, W. Tigchelaar, H. M. Schüller, and C. J. F. Van Noorden. “BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS.” The Journal of Bone & Joint Surgery British Volume 79-B, no. 5 (1997): 837-843. https://doi.org/10.1302/0301-620X.79B5.0790837

Van Der Vis HM, Marti RK, Tigchelaar W, Schüller HM, Van Noorden CJF. BENIGN CELLULAR RESPONSES IN RATS TO DIFFERENT WEAR PARTICLES IN INTRA-ARTICULAR AND INTRAMEDULLARY ENVIRONMENTS. J Bone Joint Surg Br. 1997 Sep 1;79-B(5):837-843. https://doi.org/10.1302/0301-620X.79B5.0790837

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Abstract

We examined the cellular responses to various particles injected into the knees and the intramedullary femoral cavities of rats in the presence of polymethyl-methacrylate (PMMA) plugs.

The intra-articular particles were mainly ingested by synovial fibroblasts. Increased numbers of macrophages were not detected and there was only a slight increase in synovial thickness.

Cellular responses in the intramedullary space were similarly mild and bone resorption around the PMMA plug did not occur. Bone formation was inhibited only by polyethylene particles.

In contrast to current views, our study shows that wear particles per se do not initiate bone resorption.

Correspondence should be sent to Dr H. M. Van Der Vis.

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