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Research

THE PREVENTION OF PROSTHETIC INFECTION USING A CROSS-LINKED ALBUMIN COATING IN A RABBIT MODEL

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Abstract

We evaluated the effects of a serum protein coating on prosthetic infection in 29 adult male rabbits divided into three groups: control, albumin-coated and uncoated. We used 34 grit-blasted, commercially pure titanium implants. Eleven were coated with cross-linked albumin. All the implants were exposed to a suspension of Staphylococcus epidermidis before implantation.

Our findings showed that albumin-coated implants had a much lower infection rate (27%) than the uncoated implants (62%). This may be a useful method of reducing the infection of prostheses.

Correspondence should be sent to Professor R. J. Friedman.
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Information

Journal

The Journal of Bone & Joint Surgery British Volume

Volume

79-B No.5 | Pages 816 - 819

Section

Research

Published

01 September 1997

DOI

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Assistant Professor

Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425-2239, USA.

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Medical Student

Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425-2239, USA.

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Associate Professor of Bioengineering

Clemson University, Clemson, South Carolina, 29634 USA.

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Professor

Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425-2239, USA.

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