header advert
Orthopaedic Proceedings Logo

Receive monthly Table of Contents alerts from Orthopaedic Proceedings

Comprehensive article alerts can be set up and managed through your account settings

View my account settings

Visit Orthopaedic Proceedings at:



Full Access

General Orthopaedics

Novel biodegradable MAACP/n-HA (multi-amino-acid copolymer/nano-hydroxyapatite) composite artificial lamina following spinal surgery for Lamina reconstruction

The South African Orthopaedic Association (SAOA) 58th Annual Congress



To evaluate the efficacy of novel biodegradable MAACP/n-HA composite artificial lamina for the prevention of postlaminectomy adhesions and lamina reconstruction.


Goats were randomly divided into three groups: an experimental group consisting of twelve goats that underwent cervical 4 laminectomies, followed by MAACP/n-HA composite artificial lamina implantations; a control group of nine goats whose cervical 4 vertebra plate were removed; and a normal group of three goats that did not receive any operations or treatments. On weeks 4, 12 and 24, two goats, two goats, three goats in the test group and two, two, two in the control group were selected using X-ray, CT, MRI and subsequently killed for histological examinations and SEM (scanning electronic microscopY). On week 24, the adhesion level of scar tissue was examined according to Rydell's degree of adhesion criteria. Biomechanical measurements were carried out at week 24 on 3 goats in the test group, 3 in the control group, and 3 in the normal group.


In the experimental group, the artificial lamina refrained from shifting, and no dural adhesion pressure was observed. New goat cervical natural bone formed in the defect and the bony spinal canal had reformed. In contrast, in the control group, fibrous scar tissue filled the defect and the scar tissue continued to exert pressure on the dura.


Artificial lamina could prevent the epidural adhesions surrounding the defect and promote effectively bone tissue repair and new bone formation.