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Sutures and Fibrine glue (S+F), S+F and chondrotinase ABC, S+F and electrical stimulation, S+F and chondrotinase and electrical stimulation, uninjured nerve. Video kynematic, EMG, muscle strengh and axonal count were used to asses nerve recovery at 150 days post-repair.
empty (N=5), iliac crest autograft (N=6), or PLGA/CaP biodegradable scaffold Tissue Regeneration Therapeutics Inc., ON, Canada) (N=7).
Fluorescent markers were given at different times: calcein green (six weeks), xylenol orange (nine weeks), and tetracycline (11 and 14 weeks). Animals were sacrificed at 15 weeks and perfused with a barium compound. Radiography, Micro CT, and brightfield and fluorescent microscopy were used for analysis.
osteoblast-hVEGF, fibroblast-hVEGF, Osteoblasts alone, and Fibroblasts only.
The cultured cells were harvested at 1, 3 and 7 days after the transfection. The total mRNA was extracted (TRIZOL); both hVEGF and rat VEGF mRNA were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and quantified by VisionWorksLS.
gold compound was reduced in the presence of lysozyme to form Lys-AuNPs or citrate-stabilized AuNPs were functionalized with mercaptopropionic acid (MPA) to produce carboxylic acid terminated AuNPs which were mixed with lysozyme.
Both solutions were characterized with transmission electron microscopy, ultraviolet-visible spectroscopy, circular dichroism spectroscopy (CD), and enzymatic assays. Next, AuNPs were prepared on 99.5% titanium foil discs (n=32) through electroless deposition. Deposition parameters were modified to create two groups of discs with different average diameters of AuNPs, measured by scanning electron microscopy. Some discs from both groups also underwent treatment with MPA. All discs were treated with lysozyme and the adsorbed amounts and activities of lysozyme were examined with micro BCA and enzymatic assays.
no knee brace, no load, no knee brace, 15% bodyweight (BW) load, knee brace, no load, knee brace, 15% BW load.
Patellar tracking (flexion, spin and tilt; proximal, lateral and anterior translation) was assessed. Comparisons were made at 1° increments over the coincidental range of knee flexion between the no-brace and brace conditions, at no load and 15% BW load, using a paired t-test with Bonferroni correction.
combine FA and Vancomycin, and Linezolid alone in PMMA cement and characterize antibiotic elution, and to improve drug release using polyethylene glycol (PEG) and NaCl in PMMA cement.
computed tomography absorptiometry (CT-OAM) which uses maximum intensity projections to assesses peak density values within subchondral bone, and our novel computed tomography topographic mapping of subchondral density (CT-TOMASD) technique, which uses surface projections to assess both cortical and trabecular bone density at specific depths from the subchondral surface.
Average BMD at normalized depths of 0–2.5mm, 2.5–5.0mm, and 5.0–10mm from the surface were assessed using CT-TomasD. Regional analyses were performed consisting of:
medial/lateral (M/L) BMD ratio, and BMD of a 10mm diameter core identified as having the maximum regional BMD.
Each bone was assessed for OA using a modified-KL scoring system: Normal (mKL=0); Early-OA (1–2); and Late-OA (3–4).
A radio-opaque surrogate cord, with material properties matched to in-vivo specimens, replaced the real spinal cord. Sagittal plane X-rays imaged the surrogate cord in the spine during testing. Varying levels of canal stenosis were simulated by a M8 machine cap screw that entered the canal from the anterior by drilling through the C5 vertebral body. Pure moment loading and a compressive follower load were used to replicate physiologic and super-physiologic motion.
T8-L4 fusion and facet capsulotomy at L4–L5 and L5-S1; L4–L5 Maverick; L5-S1 Maverick.
Maverick total disc replacement and fusion with the CD Horizon system was performed. Repeated measures ANOVA was used to analyze changes in ROM and HAM of the L4–L5 and L5-S1 segments.
locking plate fixation alone and locking plate fixation with intramedullary allograft fibular bone peg augmentation.
lateral 8-hole 3.5 mm conventional non-locking proximal tibial plate [CP]; CP + posteromedial 6 hole 3.5 mm limited contact dynamic compression plate [CP + LCDCP]; CP + postero-medial 6 hole 1/3 tubular plate [CP + 1/3 tubular]; 8-hole 3.5mm Proximal Tibial Locking plate [PTLP]; 8-hole 3.5 mm LCP (locking compression plate) proximal tibia plate [LCP]; 9-hole Less Invasive Stabilization System [LISS] plate.
Specimens were cyclically loaded to failure or a maximum load of 4000N. Load at posteromedial fragment failure was recorded.
antibiotics were withheld until cultures obtained, at least four fluid and tissue cultures were submitted, frozen sections were obtained of any tissue grossly suspicious for infection, and the surgeons’ pre-, intra-, and post-operative suspicion for infection were recorded.
Samples were observed for growth for 28 days. All cases were reviewed at a mean follow-up of 4.2 months (range, 1–12). Comparisons were made between infection cases and “clinically Insignificant” cases, with respect to: (1) risk factors, (3) symptoms/signs of infection, (2) active range-of-motion, (2) Simple Shoulder Test (SST) scores, values of (3) WBC, (4) ESR and (5) CRP, number of positive cultures for (6) P acnes and (7) other organisms and (8) subjective pre-operative, intra-operative and postoperative suspicion for occult infection.
to define the articular injuries of PM fractures into clincially relevant groups, as complex articular injuries could require specific surgical steps; to identify clinical and radiographic parameters which would alert the surgeon to the presence of complex injuries.
an axial loading injury mechanism (.000), a radiographically captured dislocation (.006), posteromedial comminution [as defined Tor-netta] (.005) the size of the fragment (.000).
For example, axial loading would result in a complex fracture in > 85% of cases. In contrast, there was a statistically significant association between a Weber C fracture and older age and the presence of a SIMPLE PM fracture. These factors being potentially “protective” from joint comminution.
prompt surgeons to order further imaging (CT) to better delineate the lesion, and draw his/her attention to potentially malaligned fragments at the time surgery.
The anterior-posterior (AP) dimension of the end plates. Amount of subsidence. The distance between the TDA and the posterior and anterior borders of the vertebra bodies (to represent the extent of uncoverage of the endplate by the TDA). The AP dimension of the TDA metal end-plate.
The ratio between the actual and radiographic AP length of the metal endplate was calculated and utilized as the correction factor for the error of magnification on all other radiographic measurements.
determine the extent to which the American College of Chest Physicians (ACCP) guidelines for VTE prophylaxis are followed after total hip replacement (THR) and total knee replacement (TKR) and evaluate the incidence of VTE for patients receiving and not receiving prophylaxis according to ACCP guidelines (‘ACCP’ and ‘non-ACCP’, respectively).
received LMWH, fondaparinux, or VKA following surgery initiated prophylaxis within one day of surgery (for THR patients) and were prescribed prophylaxis for a minimum of ten days, or until the occurrence of major bleeding, VTE, or death. In addition, the number of DVTs and PEs occurring in ACCP and non-ACCP patients was recorded.