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View my account settingsThe aim of the New Zealand Elbow Arthroplasty Register is to evaluate the provision of elbow arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all elbow replacements performed in New Zealand. An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete a questionnaire to measure the pain and function of the replaced elbow and to comment on any post operative complications. Data from 99 consecutive primary and 16 revision elbow arthroplasties was prospectively collected from January 2000 till December 2003. Rheumatoid arthritis was the commonest indication (63 cases) and the outcome was significantly better than for trauma and osteoarthritis. The Coonrad-Morrey was the most commonly used prosthesis (86 cases) followed by the Kudo (eight cases) and the Acclaim (five cases). 21 surgeons performed elbow arthroplasty during the study period but only five performed on average more than one case per year. Their results at six months were statistically superior to those provided by other surgeons. The number of complications reported by patients and the revision rate within the study period was low. An infection was seen in only two patients. The New Zealand Elbow Arthroplasty Register has become a robust method of assessment of the provision of elbow arthroplasty within the country. Our findings support the idea that elbow arthroplasty should not be performed by general orthopaedic surgeons on an occasional basis.
We compare the management and outcome of two management stratergies for the perfused but pulseless hand following stabilisation of grade III supracondylar fractures in children.
For this study we looked at 15 patients treated in two centres (all treated by the senior author) between 1995 and 2004. The patients were designated to group I if the pulseless hand had been observed or group II if they underwent immediate exploration. Data collected included time to surgery, neurological deficit, time to return of pulse and subsequent symptoms of forearm claudication. All patients were seen at week 1,3 and followed for at least 6 months post surgery. Radiographs were reviewed to determine the adequacy of reduction of the fracture.
The mean age of patient was 3.8 years. Median time to surgery was 6 hours. 6 children had evidence of anterior interosseus nerve palsy. 12 cases were reduced anatomically, 3 had minimal fracture gap. Of the 8 patients in group I (observation) 2 had secondary exploration and one developed claudication symptoms. All had palpable radial pulse at 3 months.6 of the 7 patients in group II (exploration) were seen to have brachial artery tethering, 2 with median nerve entrapment. 5 of them had subsequent return of radial pulse within 24 hours.
Satisfactory radiological reductionof the fracture does-not exclude vessel or nerve entrapment. We would advocate early exploration of the artery if the pulse does not return within 24 hours.
Goodfellow & Bullough (1968) first described the pattern of articular cartilage wear in the elbow. More recent post mortem studies have shown that advanced degenerative changes can develop in the radio-capitellar (lateral) compartment of elbow joints of elderly subjects in which the humeroulnar (medial) compartment remains remarkably well preserved. We have reviewed the findings in a consecutive series of 117 elbow arthroscopies performed on patients with elbow pain resistant to conservative treatments (age range 21–80 years: mean age 51 years). We documented established degenerative changes involving articular cartilage in 68 patients (59%). In this group we found that in 60 patients (88%) the degenerative changes were confined to the lateral compartment and contrasted with normal appearances of the articular cartilage of the medial compartment.
The post mortem studies carried out on mainly elderly subjects demonstrated that the degree of degenerative change in the elbow is age dependant and involves predominantly the lateral compartment of the joint. Our study would support these observations, but indicates that symptomatic degenerative change occurs at a much earlier age than had previously been thought.
We consider that lateral compartment degenerative change is a distinct clinical entity. It begins in relatively young patients in whom the x ray appearance may be normal or near normal and is often diagnosed as lateral epicondylitis. Our observations taken together with the reported post mortem studies indicate that primary osteoarthritis of the elbow begins in the lateral compartment of the joint and may remain confined to the lateral compartment throughout life. We believe that new treat ment strategies need to be developed specifically for patients with primary osteoarthritis as opposed to degenerative joint disease due to other causes.
We present a single-surgeon series of surgical release of post-traumatic flexion contracture of the elbow performed via a limited lateral approach. We undertook a retrospective review of patients having surgery for established post-traumatic flexion deformity of the elbow. All patients underwent anterior capsulectomy via a limited lateral approach. Patients with an intrinsic contracture also had the intra-articular lesion addressed at the time of surgery. Short-term follow-up was available from clinical review until discharge. Medium-to-longterm follow-up was conducted by telephone interview supplemented by clinical review in selected cases.
Between 1998 and 2004, 23 patients were treated surgically for established flexion contracture of the elbow. There were 15 males and 8 females with a median age of 35yrs (range 16–52yrs). In sixteen patients the contracture was not associated with damage to the joint surface (extrinsic) and in seven it was (intrinsic). The mean pre-operative deformity was 55 degrees (95%CI 49 “ 61) which was corrected at the time of surgery to 18 degrees (95%CI 12 “ 23). The mean residual deformity was 25 degrees (95%CI 20 “ 31). The difference between the pre-operative and discharge deformities was significant (Wilcoxson test p< 0.001). In the extrinsic group the mean deformity at discharge was 21 degrees (95%CI 17 “ 25) compared to 34 degrees (95%CI 19 “ 49) in the intrinsic group “ this difference was significant (Mann-Whitney U test p< 0.01). In those patients with an extrinsic contracture all elbows had a return of functional extension. One patient suffered a post-operative complication with transient dysaesthesia in the distribution of the ulnar nerve which resolved after six weeks. Surgical release of post-traumatic flexion contracture of the elbow via a limited lateral approach is a safe, reliable technique with the best results achieved in patients with an isolated extrinsic contracture.
The aim of this study was to establish the consensus of opinion amongst trauma surgeons for the management of displaced supracondylar fractures of the humerus in children.
We carried out a postal questionnaire involving 130 orthopaedic surgeons with an interest in paediatric trauma. They were identified as being members of the British Society for Children’s Orthopaedic Surgery.
We received a response rate of 65%. One third of respondents believe that in uncomplicated fractures, reduction should occur within 6 hours of injury and one half felt that ‘pulseless’ fractures should be treated in the same time frame. 60% said they would explore a pulseless arm after midnight, but only 20% would reduce and stabilise uncomplicated fractures. 82% of surgeons stabilise displaced grade III fractures with K wires, of these, the majority would use a‘crossed’ configuration. If after stabilisation the arm remained pulseless, only 16% said they would explore the brachial artery immediately, 23.5% would seek a vascular opinion and 60.5% of surgeons would observe for 24 hours. If the arm remained pulseless but pink after 24 hours, the majority of surgeons would continue to observe and rely on collateral circulation for distal perfusion.
The majority of surgeons would stabilise displaced supracondylar fractures as soon as possible but not after midnight unless the arm was pulseless. If the hand remained pink but pulseless, most felt that continued observation beyond 24 hours was acceptable.
The normal shoulder requires the basic mechanical characteristics of range of motion, stability and strength. However, each of these characteristics can be compromised by arthritis or rotator cuff tear and are often associated with strong pain. Shoulder arthoplasty is one of the most common solutions for pain relief and to restore shoulder functionality. There are many available designs of prosthesis trying to address different shoulder pathologies. Despite this, there are relatively few studies investigating the biomechanics of a total joint replacement and suggest advantages, disadvantages and possible solutions.
The Newcastle shoulder model has been used to investigate the biomechanical properties of a total shoulder replacement having a reverse anatomy design. This model allows the simulation of implantation of the prosthesis and the prediction of muscle and joint forces. To address the requirement of accurate insertion of the prosthesis, the standard surgical procedure has been simulated. The current model was modified to represent the bones, muscles and implant alignment after surgery.
Load sharing results for standardised tasks (Abduction, Forward Flexion) showed great differences between anatomical and prosthetic models. In the latter the shear forces on the glenoid site were reversed, the compression stresses were reduced and the joint contact vectors were always within the humeral cup providing joint stability. This is an important effect of the reverse design, which reverses the envelope of the joint forces increasing also the muscle moment arms crossing the GH joint. The most affected group is the m.deltoid that becomes able to compensate for the dysfunctional rotator cuff muscles. The biomechanical model suggests that a reverse anatomy design can restore GH joint stability for patients with severe RC damage. Increased muscle moment arms also compensate for the lost contribution of the RC muscles to elevation.
We present the early results of 36 primary total elbow arthroplasties using the Acclaim prosthesis. The Acclaim prosthesis was used in 46 primary total elbow arthroplasties between July 2000 and August 2002. All operations were performed or directly supervised by the two senior authors (IAT and JKS). There were 32 females and 14 males. The mean age at surgery was 64 years (range, 34–93). The underlying pathology was rheumatoid arthritis in 39, osteoarthritis in five and post-traumatic arthritis in two. The early results of 36 cases are presented at a minimum follow-up of two years. Patients were assessed using the American Shoulder and Elbow Surgeons patient self assessment form and the range of movement of the elbow measured. The Wrightington method was used for radiographic analysis of lucencies. There was good relief of pain and range of movement improved. The mean preoperative pain score was 8.1 and decreased to 2.1 at latest follow up. The mean disability score increased from 34.2 to 66.1. The mean overall satisfaction rating following surgery was 9.3 on a visual analogue scale from zero to ten. The mean range of flexion increased from 83oto105o. The mean flexion gain was just over 10o and the mean extension gain was just over 12o. There were 11 cases of intraoperative fracture of the humeral condyle. One of these fractures failed to unite and required revision to a linked prosthesis because of persistent instability. There was one case of deep infection. There were three cases of ulnar neuropathy, one of which resolved. There was no evidence of loosening. The Acclaim total elbow arthroplasty gives good symptomatic relief and improvement in function according to the American Shoulder and Elbow Surgeons patient self assessment form. These early results are encouraging but the frequency of intra-operative fractures is of some concern.
A significant number of patients return with persistent symptoms following surgical release of the posterior interosseous nerve for radial tunnel syndrome. The aim of this study was to attempt to explain this fact in anatomical terms by defining the anatomy of the posterior interosseous nerve and its branches in relation to the supinator muscle and arcade of Frohse. Using standard dissection tools 20 preserved cadaveric upper limbs were dissected. The radial nerve and all its branches within the radial tunnel were exposed and a digital calliper was used to measure distances. The bifurcation of the radial nerve to posterior interosseous nerve and superficial sensory branch occurred at a median distance of 4.35mm proximal to the elbow joint-line. The bifurcation was proximal to the joint-line in 11 cases, at the level of the joint-line in one case and distal in eight cases. There was a range of 0–5 branches to the supinator originating proximal to the entry point of the posterior interosseous nerve under the arcade of Frohse at a median distance of 10.27mm (medial branches) or 11.11mm (lateral branches) distal to the elbow join-line. These branches either passed under the arcade of Frohse or entered through the proximal edge of the superficial belly of the supinator. In 10 limbs there was a variable number of branches to the supinator originating under its superficial belly and in five limbs multiple perforating posterior interosseous nerve branches within the muscle were identified. This variation in anatomy we believe may explain the persistence of symptoms following surgical release of the posterior interosseous nerve for radial tunnel syndrome and suggests that careful exploration of all the nerve branches during surgical decompression should be routinely performed.
The purpose of this study was to assess the efficacy of physiotherapy approaches to treatment of rotator cuff tendinopathies (RCT). Ninety shoulders were randomised in the study. A power calculation performed demonstrated using a factorial study design, 85 shoulders would be needed for 80% power at 95% confidence. All participants gave informed consent and ethical approval was granted by the Cambridge LREC. The primary outcome measure was the Shoulder Pain and Disability Index. Participants were blinded to their allocation and were randomised to one of four groups: Therapeutic Exercise(T), Manual Therapy(M), combined T/M (X), or Placebo(P). Participants were seen for two baseline assessments with a 4-week interval and then randomised. Final assessments were performed one week after the last session. The analysis involved a comparison between groups in change from baseline SPADI using ANCOVA adjusting for baseline scores. This involved testing for any interaction between M and T, and subsequently testing for main effects of M and T. Adjusted baseline and final SPADI scores (SD) by group were: X 41.6(15.4), 21.1(20.8); T 47.6(19.3), 26.3(14.7); M 44.1(17.9), 33.1(23.3); and P 39.5(24.7), 36.6(30.6). The main effects (with Significance, Standard Error and Confidence Interval) by group were: Baseline=0.686 (SE=0.104;CI=0.479,0.892); T=−13.347 (p=0.002;SE=4.091;CI=−21.479,−5.215); X=5.479 (p=0.510;SE=8.284; CI=−10.991,21.950); M=−4.126 (p=0.314;SE=4.077;CI=−12.230,3.978). A statistically significant reduction in SPADI was observed for the T group alone. There was no significant interaction effect with the addition of manual therapy and the M group did not improve significantly. It appears that best practice for treatment of RCT should centre around therapeutic exercise.
Ultrasound imaging has become an essential adjunct to clinical examination when assessing a patient with suspected rotator cuff pathology. With the new high-resolution portable machines it has become feasible for the shoulder surgeon to perform the scans himself in the clinic and save a great deal of time. This study was conducted to examine the accuracy of the ultrasound scans performed by a single surgeon over a period of four years. The ultrasound findings were uniformly documented and collected prospectively. Out of a total of 364 scanned patients we selected 143 who ultimately received an operation and we compared the surgical findings with the ultrasound reports. The intra-operative findings included 77 full thickness supraspinatus tears, 24 partial thickness tears and 42 normal cuffs. Three full thickness tears were missed on ultrasound and reported as normal / partially torn. Four normal/ partially torn cuffs were thought to have a full thickness tear. This presents 96.3% sensitivity and 94.3% specificity for full thickness tears. Three partial thickness tears were reported normal on ultrasound and eight normal cuffs were thought to have partial thickness tears. This presents 89% sensitivity and 93.7% specificity for partial thickness tears. The size estimation of full thickness tears was more accurate for large/massive tears (96%) than moderate (82%) and small/pinhole tears (75%). The tear sizes were more often underestimated which may partly reflect disease progression during the unavoidable time lag between scan and surgery. We conclude that shoulder ultrasound performed by a sufficiently trained orthopaedic surgeon is a safe and reliable practice to identify rotator cuff tears.
Progressive arthritis can occur in association with massive tears of the rotator cuff. Altered joint kinematics are commonly proposed as the principle causative factor but this does not explain the absence of arthropathy in some patients. We have investigated the role of the
The management of bony lesions associated with glenohumeral instability has been open to debate. Invariably a significant period of time elapses between injury and surgery during which the bony fragment may atrophy and reduce both in size and in quality. Histomorphometric bone analyses were prospectively performed on the glenoid bone fragments harvested during the modified Latarjet operation. The main purpose of the study was to assess the viability of the bone. Biopsies were obtained from 21 patients that had given informed consent. Median age was 21 years (range 16–50). All were male patients. The most important sports identified were rugby (64%) and water sports (surfing, water polo, water skiing, surfing (21%)). Mean glenoid bone loss on CT scan was 17% (range 10–50%). Thirty-three percent had bone loss greater than 20%. Gross morphology of glenolabral fragments identified a single large fragment (11/21); dominant large fragment plus smaller fragments (7/21); multiple fragments (4/21). Single large fragments comprised 52% of the study. Mean volume and mass of bony fragments were 2.18 ml (range 1–3 ml) and 1.64 gms (range 0.43–2.8 g), respectively. Histology of the specimens revealed no bone in three of the 21 specimens. Bony necrosis was present in 8/18 (44%) of the specimens. From a histopathological point of view, reattachment of these devitalized bone fragments by screws or anchors may result in predictable operative failure and recurrent instability. We can therefore not support the practice of “repair” of bony Bankart lesions based on the above findings.
The aim of this study was to assess the accuracy of Magnetic Resonance Arthrography (MRA) in symptomatic shoulder joint instability. Data were collected prospectively from MR Arthrograms performed in 40 consecutive patients with recurrent symptomatic instability. MR Arthrograms included views in the stress ABER position of the shoulder. Subsequently all patients underwent an arthroscopic shoulder stabilisation and the arthroscopic and MR Arthrographic findings were correlated. In case of discrepancy the films and operative findings were reviewed.
There were thirty three male and seven female patients with a mean age of 28 years (range 18–40). MR Arthrography showed 37 anterior-inferior tears (22 displaced Bankart tears, 8 nondisplaced Bankart tears, 5 chronic ALPSA lesions and 2 AGL lesions) and 3 posterior lesions. There were 3 discrepancies of which 2 were cases of missed Bankart lesion on MRArthrogram and one case of reverse Perthes lesion present on MRArthrogram but not seen on arthroscopy. Despite a review of the films, the missed Bankart’s lesions were not visualised. In the present study, MR arthrography had a 95% sensitivity in detecting ligamentolabral pathology and a positive predictive value of 0.975 in diagnosing a lesion in recurrent shoulder instability.
The results show that MR Arthrogram is a highly useful tool for investigating recurrent shoulder instability with very high sensitivity and positive predictive value. Of the 40 patients who underwent arthroscopy there were only 2 cases where MR Arthrography did not demonstrate an arthroscopically detected abnormality.
We report our experience of revision shoulder arthroplasty at Wrightington Hospital. Thirty-Nine patients had undergone revision surgery and followed up for a minimum of two years. Patients were scored using the Constant score and the ASES score pre-operatively and post operatively. All patients had X-ray evaluation for loosening and migration. Of the thirty-nine patients, 16 were failed humeral head replacement (HHR) and 16 were failed total shoulder replacement (TSR). All but two of the HHR were revised for glenoid erosion to a TSR, there was an equal proportion of patients with rheumatoid arthritis and osteoarthritis. Of the 16 patients undergoing revision surgery for failed TSR 6 were rheumatoid, 4 had osteoarthritis and 5 had posttraumatic arthritis. The main reasons for revision include glenoid loosening (7) instability (4) and peri-prosthetic fracture (2). The average constant scores post operatively for HHR and TSR were 35.5 (sd+/− 21.1) and 29.1 (sd+/− 12.1) respectively. The average ASES scores for HHR and TSR were 60.5(sd +/ 27.8) and 50.1(sd +/− 22.0) respectively. There was no statistical difference between the two groups in respect to the constant scores (p value 0.18) or ASES scores (p value 0.16). Overall, the pain relief was good post operatively following both HHR and TSR. The mean visual analogue score for pain following HHR was 3.2 and following TSR 3.5. Range of movement, function and strength was poor following both HHR and TSR.
HHR fail in a predictable way and can be revised with conversion to a TSR. TSR fail in a variety of ways and there revision surgery is demanding and complex. Both types of revision offer good pain relief but poor function.
The site of the non-union is approached through the pre-existing scar and any remaining metalwork is removed. The ends of the non-union are mobilised and bone is resected from both ends until there is fresh bleeding. The two bone ends are fashioned such that one will fit as a spike inside the medullary cavity of the other. The bone ends are held in position with two temporary K wires until the frame has been applied.
A standard four ring Ilizarov frame is applied with Rancho pins in the proximal humerus and a half ring in the distal humerus. The temporary K wires are removed and the frame is compressed to increase the contact between the bone ends. The routine hospital stay is one week and the patients are given intravenous antibiotics throughout their admission.
They are reviewed in the outpatient clinic at monthly intervals and the frame is used to compress the bone ends by two to three millimetres on each visit. When there are radiographic signs of union the frame is removed under a general anaesthetic.
The purpose of this study was to test the null hypothesis that patients with partial thickness rotator cuff tears do not suffer more pain or stiffness than those with full thickness tears. A power study determined that 68 partial thickness tears were required in the study in order to prove a clinically important difference (± = 0.05 and 2 = 0.2). Consecutive patients undergoing arthroscopy and bursoscopy for rotator cuff related problems were assessed using a pain analogue scale and their shoulder movements were measured. Information was gained both pre- and intra-operatively about possibly relevant confounders including age, site size and thickness of tears, and endocrine disorders. Exclusion criteria included glenohumeral arthropathy, frozen shoulder, instability and major traumatic injuries, as well as the inability to understand the pain score. 439 shoulders (428 patients) were included in the study; 216 shoulders had no cuff tear, 95 had partial thickness tears (75 joint side, 1 intrasubstance, 19 bursal side), and 128 shoulders had full thickness tears. There was no significant difference (p< 0.05) in the pain scores or range of movement between full and partial thickness tears. Age was the only independent variable to have an effect on pain score.
The null hypothesis has been upheld. This study contradicts the findings of previous research and challenges commonly held assertions on this topic. Neither pain nor stiffness can be used clinically as discriminators between partial and full thickness rotator cuff tears.
Thirty-five patients (85%) reported none or minimal pain. 81% were negative for provocative AC signs. Internal rotation increased by average of 5 vertebrae levels. The Constant, the WORC and Oxford Scores were improved by 23 points, 674 points and 16 points respectively (p< 0.05). 71% reported good or excellent function by the 3rd post-operative month.
The aim of this study was to observe cellular and vascular changes in different stages of full thickness rotator cuff tear.
Biopsies of the Supraspinatus tendon in 40 patients with chronic rotator cuff tears undergoing surgery were analysed using histological and contempary immunocytochemical techniques. Sections were stained with primary antibodies against PCNA (Proliferating cell nuclear antigen), CD34 (QBEnd 10), CD45 (Leucocyte Common Antigen), CD68, D2-40 (Lymphatic Endothelial Marker) and Mast Cell Tryptase. A histological analysis was performed with Mayer’s Haemotoxylin and Eosin, Congo Red and Toluidine Blue.
The reparative response and inflammatory component (figure 1) of the tissue was seen to diminish as the rotator cuff tear size increased. This was evidenced by increasing degeneration and oedema, reducing fibroblast proliferation, reduced thickening of the synovial membrane and reducing vascularity. Macrophage, other leucocyte and mast cell numbers also reduced as tear size increased. Large and massive tears revealed a higher degree of chondroid metaplasia and amyloid deposition when compared to smaller sized tears. There was no association with the patient’s age or duration of symptoms.
Small sized rotator cuff tears retain the greatest potential to heal and have a significant inflammatory component. Tissue from large and massive tears is of such a degenerate nature that it may never heal and this is probably a significant cause of re-rupture after surgical repair in this group. Selection of patients for reconstructive surgery should take into account the composition and healing potential of tendon tissue and its relationship to tear size in chronic tears of the rotator cuff.
This is a prospectively randomised blind study to determine which treatment- Manipulation under anaesthesia (MUA) or Hydrodilatation is more effective for proven shoulder adhesive capsulitis. Forty patients with adhesive capsulitis were randomised to receive either of the two treatments. All patients were assessed by an independent investigator, with Visual Analogue Scores (VAS) and Constant scores, at three intervals “ pre-treatment, 2 months and 6 months following treatment. Twenty patients (mean age 55.2 years (44–70); duration of symptoms 33.7 weeks (8–76)) received hydrodilatation and eighteen (mean age 54.5 years (39–69); duration of symptoms 43.5 weeks (12–102)) underwent MUA (two patients dropped out). VAS scores in the hydrodilatation group were pre treatment 6.1 (n=20), 2.4 (n=18;p=0.001) at 2 months and 1.7 (n=17; p=0.0006) at 6 months. VAS scores in the MUA group were pre treatment 5.7 (n=18), 4.7 (n=16) at 2 months, and 2.7 (n=15;p=0.0006) at 6 months. The VAS pain scores in the hydrodilatation group were significantly better than the MUA group over the six month follow-up (p< 0.0001)Constant scores in the hydrodilatation group were 30.8 pre treatment, 57.4 (p=0.0004) at 2 months and 65.9 (p=0.0005) at 6 months. In the MUA group, Constant scores were 38 pre treatment, 60.2 (p=0.001) at 2 months and 59.5 (p=0.0006) at 6 months. Constant scores in the hydrodilataion group were again significantly better than the MUA group over the six month follow-up (p= 0.02). At final follow up, 93% of patients were satisfied or very satisfied after hydrodilatation compared to 71% of those receiving an MUA.
We have for the first time prospectively measured the outcome of two treatments “ MUA and hydrodilatation in patients with adhesive capsulitis. Our results suggest that although both treatments are effective in the majority of patients, hydrodilatation is significantly more effective than a manipulation under anaesthesia.
To study the outcome of complex proximal humeral fracture sequelae (Type 3 & 4) treated with the Delta III Total Shoulder Replacement (TSR) Prosthesis. This is a prospective outcome study involving 10 patients mean age (71.5 yrs). All patients failed conservative treatment of proximal humeral fractures. Mean time from injury to surgery was 10.5 (+/− 11.5) months. All patients underwent a Delta III TSR via McKenzie approach by a single surgeon. Patients were assessed clinically with Constant scores, asked whether they were satisfied, and radiologically with plain film radiographs. Since last review one patient has died. Mean time at follow up was 20.8 months post-operation (12 “32 months). Three patients had undergone early revision for dislocation. Since last review two patients have developed deep infection, one treated with washout and suction drain, one with removal of prosthesis. One patient has a clinical diagnosis of complex regional pain syndrome. Three patients are very happy with the outcome of surgery, one is happy, one unhappy and four very unhappy. The mean pre-operative Constant scores was 8.9 (2–15), at first review 44.4 (15–96) and now 35.8 (4–76). The mean pain score on a visual analogue scale (0–10) was 3.6 (0–10). Radiographs showed no progressive notching of the glenoid in any patient. Mean flexion was 93 degrees (10,170), mean abduction 61 degrees (10,100) and mean external rotation was “1 degrees (−20,20).
This is a new technique for treating proximal humeral fracture sequelae. Some individual results are excellent. There has been a high complication rate and a significant rate of poor results. At this time we cannot recommend the reverse geometry prosthesis for the treatment of proximal humeral fracture sequelae.
This study was performed to evaluate the efficacy of interscalene block combined with general anaesthetic for common surgical procedures of shoulder and the potential of this procedure for providing day case shoulder surgery.
114 consecutive patients undergoing shoulder surgery were audited using a questionnaire immediately after operation and at 6, 12 and 48 hours after operation. Pain scores were recorded based on visual analogue scale, type of operation, duration of operation, postoperative stay and complications. At 48 hours overall pain control was assessed and patients were asked about having their operation done as a day case.
104 patientswho responded to the questionnaire were included in the study. There were 52 males and 52 females with overall mean age of 49 years (range 18–85). 75 patients underwent arthroscopic decompression, 15 patients underwent arthroscopy assisted mini open cuff repair, 9 underwent open glenohumeral stabilisation and the rest five underwent open Mumford procedure. Mean operation time was 47 minutes (range 25–90). 97 (93%) patients had no pain immediately postoperatively, 76 (73%) patients were pain free at 6 hours and 39 (38%) were pain free at 12 hours. Mean pain scores art 6 hours was 3 and at 12 hours were 4. 101 patients said their pain was well controlled throughout the first 48 hours by simple oral analgesics. 84 (83%) patients expressed an opinion that they could have been managed as day case provided they were adequately counselled about the procedure. 6(5.7 %)patients showed signs of Horner’s syndrome that resolved by 12 hours. No other complications related to inter scalene block occurred.
This study has shown that interscalene block is a safe procedure providing sustained adequate pain relief after shoulder surgery. It could allow a high percentage of patients undergoing shoulder surgery to be discharged home on the day of surgery.
The aim of this randomised, controlled trial is to compare subacromial steroid injections, physiotherapy and both interventions with a control treatment in early painful arc of the shoulder.
Over a six-month period patients with “painful arc”, of less than six months duration, were recruited via their GPs. Eligible patients were consented to enter the trial and were then randomised, by sealed envelopes, to one of four arms of the study: control (normal analgesia and/or non-steroidal anti-inflammatory medication), a specified and repeatable Exercise and Manual Therapy Package (EMTP), a course of up to three subacromial steroid injections or both the EMTP and the steroid injections. The interventions and clinic follow-ups were over an 18-week period. A final postal questionnaire was sent out at one year. The progress of the patients was monitored using the Oxford Shoulder Score (OSS) and the SF36 general health questionnaire.
Seventy-nine GPs referred 186 patients, of whom 112 were randomised (Control=27, EMTP=29, Injections=28, Both=28). 64 patients were female and 48 male. The mean age was 54.5 years (range 23–88 years). Ninety patients completed the trial (Control=20, EMTP=22, Injections=26, Both=22). Sixty-two returned the follow-up questionnaire. By paired sample t-tests, no significant differences were found between the OSS scores or SF-36 (physical health total) at the beginning and end of the intervention period, or at one year. Two patients in the injection group went on to surgery, along with one each in the control and EMTP groups.
We have found no significant differences in outcome between steroid injections, a physiotherapy package, both treatments, or symptomatic treatment in our group of patients presenting with symptoms of painful arc of the shoulder.
The purpose of this study is to report the 1 to 5 year results of arthroscopic Rotator Cuff repairs.
Between November 2001 to May 2003, 115 consecutive patients were operated (73 males and 42 females) with arthroscopic repair. 13 patients were lost to follow up, leaving 102 patients available for follow up. Patients were evaluated using the Constant score, satisfaction levels and ultrasound scan to evaluate cuff integrity. Failures were defined as dissatisfied patients and those who had had a re-operation. Re-tear rate was recorded.
The mean follow up time was 23.8 months (range 12–61). Mean age was 57.3 years (range 23–78). 47% had a history of trauma. There were 107 patients (95.5%) with full thickness tears and 5 (4.5%) had partial thickness tears. Of the full thickness tears, 8 (7.6%) were massive in size, 36 (34%) large, 44 (41.5%) medium and 18(17%) small. Isolated Supraspinatus (SSP) tear was recorded in 83.5% and subscapularis tear in 7 %. A combination of SSP tear with infraspinatus and teres minor was found in 9.6%.
86% had Acromioplasty (ASD) with or without an AC joint excision arthroplasty. Two patients had Bankart repairs in addition at the time of cuff repair.
The mean pre op Constant score was 40.9 points (95% CI 37.3 to 44.5), which had improved to 84.8 (CI 82.2 to 86.9) at last follow-up. 78% returned to same work and 82% returned to pre injury leisure activity. There were 20 re-tears (19.6%). eight of the 102 patients were not satisfied. Five of these patients had revision operation.
Arthroscopic cuff repair shows high satisfaction rate (92%) and good functional results with 20% re-tear rate, while offering all the advantages of arthroscopic surgery.
Thin section CT scanning has shown a higher rate of pseudarthrosis with ALIF than previously reported with standard radiological modalities. Cadaveric studies have demonstrated that posterior stabilisation would increase stiffness of the motion segment and is likely to enhance the rate of fusion with ALIF. The results of thin section CT scanning of ALIF, with and without posterior stabilisation, has not been reported previously.
All patients were monitored in recovery for two hours. Visual Analogue Scale (VAS) pain scores were assessed at 2, 4, 24 and 48 hours post-op. The time to first bolus delivery of PCA was recorded as was the total amount of morphine PCA used. Both patient and assessor were blinded.
The questionnaire comprised statements paired with a 7-point scale, ranging from 0 (do not agree) to 6 (completely agree), therefore respondents marking 0–2 would be disagreeing, and those marking 4–6 would be agreeing with that statement.
97/109 (90%) respondents agreed the patient could continue to live normally, 38 (35%) would say the scan is essentially normal and 51 (47%) would not. 21/109 (19%) would say the scan is significantly abnormal and were likely to give restrictive movement advice (13/21 v 26/88: p=0.01). Clinicians who advise against painful movements were likely to seek a surgical opinion (19/32 v 13/77: p< 0.0001)
percentage of patients with ‘acute’ (<
12 weeks) and ‘chronic’ (≥12 weeks) LBP [H: acute LBP = 4.7%, chronic LBP = 95.3%; P: acute LBP= 84.7%, chronic LBP= 15.3%; χ2 = 120.34, df=1, p<
0.001]; mean number of treatments [H=5 treatments (SD=3.8); P=2.5 treatments (SD=2); t = −6.0, df = 123, p<
0.0001]; median duration of treatment [H=6 weeks (IRQ=4-12); P=1 week (IRQ=0.14-2) p<
0.0001].
Lumbar facet joint pain cannot be reliably diagnosed clinically, the International Spinal Injection Society recommends two diagnostic local anaesthetic blocks before radiofrequency (RF) denervation [
Scoring systems may improve diagnostic accuracy. The two most popular scores disagree on the interpretation of pain induced by extension/rotation:
‘Cochin Criteria’ [
Helbig &
Lee [
Patients were selected clinically and did not undergo diagnostic blocks.
Cochin criteria, Helbig & Lee scores, work status, and outcome were taken from the case notes.
Likelihood ratios were calculated for the scores, their individual components, and work status.
Pain on extension/rotation weakly indicates a poor response to facet joint denervation.
X-rays do not help with the diagnosis.
Social factors may be more important than clinical signs.
MEDLINE (1951→) EMBASE (1974→) CINAHL (1982→) PsycINFO (1806→) AMED (1985→) PEDro.
In addition, national guidelines and key texts were hand-searched. Each red flag identified in the literature was classified using The Guidelines Development Group’s format (where 100% coverage = ‘unanimity’; 75–99% = ‘consensus’; 51–74% = ‘majority view’; and 0–50% = ‘no consensus’), and the findings summarized.
CONCLUSION: In our model the prevailing osmolality was a powerful regulator of GAG accumulation by cultured nucleus cells. In vivo prevailing osmolality is governed by GAG concentration. These results thus indicate GAG synthesis rates are regulated by GAG concentration, with implications both for the aetiology of degeneration and for tissue engineering.
reported practice (based on a vignette of a patient with non-specific LBP) beliefs and attitudes about LBP(using the HC-PAIRS, Rainville et al 1995)
Thirty patients with were treated with Dynesys system. All had discography and positional MRI preoperatively and nine months post-operatively.
The patients were divided in to two groups. The first in which only Dynesys was used and the second in which Dynesys was used with fusion.
The ROM of the end plate angle at the instrumented segments in group-A reduced from 5.24o to 2.18o{difference 3.06o(p< 0.005)} and in group-B reduced from 6.69o to 2.46o,{difference 4.23o(p=0.008)}. The ROM of the end plate angle at adjacent level in group-A changed from 8.26o to 7.0o {reduction 1.26o(p=0.388)},while in group-B increased from 6.91o to 8.64o, {difference 1.73o(p=0.149)}
The mean anterior disc height in-group A reduced by 1.43mm (p< 0.005) from 9.75mm to 8.32mm, and the posterior one was increased from 6.27mm to 6.77mm {difference of 0.5mm,(p=0.008)}. In group-B the anterior disc height reduced by 1.11mm (pre-op=10.44mm,post-op= 9.33mm,p=0.049) and the posterior one by 0.16mm (pre-op 6.98mm to post-op 6.82mm,p=0.714).
Stature change has been used to indicate the stress associated with specific tasks. Interpretation of stature change is often related to the diurnal change found in healthy participants. However, it has not been determined whether individuals with chronic Low Back Pain (LBP) experience a similar diurnal pattern. The aim of this study is to investigate diurnal stature change in individuals with and without CLBP.
Eight participants with LBP and eight matched asymptomatic controls took part in the investigation. Twenty-four stature measurements were made across a 24 hour period using a standing stadiometer. Differences between the two groups were analysed using two-way ANOVAs (time x group). Correlations between stature change and levels of low-back discomfort were examined using Spearman’s rho.
A clear diurnal variation was found for both groups, with the trough to peak variation in stature of 17.9 mm (LBP) and 17.6 mm (control) groups did not differ significantly (P > 0.05). Both groups experienced their greatest stature change in the 1st hour after rising 31.3% (LBP) and 44.6% (Control) of the total stature change. Towards the end of the day stature in the chronic LBP group reached a plateau while the control group continued to shrink. Between 2pm and 6pm both groups demonstrated a previously unreported recovery of stature. Reasons underlying this finding could be hormonal, behavioural or due to hydration status and require further investigation. A significant correlation was found between low-back discomfort and stature change in the LBP group, whereby when stature was lost greater discomfort was experienced and when stature recovery discomfort decreased.
The effect of pain on lifestyle is paramount to the patient, physical symptoms for the clinician. Acknowledging this disparity may reduce frustration experienced in consultations as both have different communication and management needs. Indicating treatment success by focusing on lifestyle improvement in patients rather than reductions in physical symptoms may be more appropriate.
We conducted a community survey of the prevalence, health impact and location of chronic pain. We explored the relationship and patterns of chronic pain that commonly occur, with a view to understanding why some treatment approaches may be more appropriate than others for particular patterns of pain.
In 2002, 2504 randomly sampled patients from 16 General Practices in the South East of England responded to a postal questionnaire about chronic pain. Those with chronic pain completed a pain drawing. We calculated descriptive statistics, relative risk and correlations to identify the associations and risks of having linked pain.
The highest prevalences were low back (23%), shoulder (20%) and knee (18%) pain. The number of pain sites experienced was age related in men but less so in women. Lower body pain was more age related than upper body and non musculoskeletal pain. Multi site pain was more common than single site pain. Of those with low back, knee and shoulder pain, 14%, 4.5 % and 1.9% had only low back, knee and shoulder pain respectively. Correlations and minimum spanning trees showed that chronic upper and lower body pain are distinct and axial pain link the two.
Chronic pain is more likely to be multi site, especially at middle age. Research, physical treatments and approaches to managing chronic pain are often site specific, therefore specialising treatment to one area eg low back pain often negates the bigger issue. This may help explain the self perpetuating problem of persistent chronic pain.
Focus group methodology was used to explore the experiences, beliefs and treatment expectations of chronic low back pain (LBP) patients in order to identify what components of treatment they considered to be of most value: specific emphasis was placed on the importance of advice and exercise to these patients.
Removing the non-core answers from the LBOS gave an R squared value of 0.130
Removing the weighting of the LBOS gave an R squared value of 0.132
Removing the non-core questions and weighting system of the LBOS gave an R squared value of 0.133
This study aimed to assess whether patients with different pain sources could be differentiated using the Oswestry Disability Index (ODI) (a validated patient questionnaire scoring ten different aspects of pain and function in patients with LBP; higher scores correlating with greater disability).
Patients with disc pain had significantly greater overall disability and scored higher for sitting, sleeping and social activity than those with facet or sacroiliac pain as judged by the 95% confidence limits of the median (p< 0.05). Patients with facet pain scored higher for walking and standing compared to those with sacroiliac pain.
For disc pain scores were higher for sitting and standing than for walking, and for facet pain scores were higher for standing than for sitting or walking.
The aim is to study whether cannabis has any role as a pain relief agent in chronic degenerated disc disease without spinal stenosis.
This suggests that the transverse process or its associated structures have an important stabilizing function on the spine.
Demographics, operation type and epidural rate were all correlated with the need for catheterization. In all cases the residual volumes were recorded.
The average residual volume at catheterization was 936mls, with a maximum of 2200mls. All patients were managed with intermittent catheterisation, most, (63%) requiring only a single episode before spontaneously voiding.
We were therefore unable to predict which patients would require catheterisation. Questioning and bladder palpation was found to be unreliable when assessing overdistention.
Our study demonstrated that patients undergoing spinal surgery using epidural analgesia should be closely monitored in order to prevent overdistention of the bladder and has led to a proactive regimen for spinal patients with epidural analgesia in our unit.
Degeneration of the intervertebral disc results in patent cracks [1] and a decrease in osmotic pressure associated with loss of fixed charges. The relationship between mechanical load and damage in the disc is very poor [2]. This finding is at odds with physical intuition. The subject of this study is relationship between the development of patent cracks and the decrease in osmotic pressure in the degenerating disc in the light of the physics of swelling [3–7]. We restrict the experimental part of this study to hydrogel, thus avoiding complications associated with biological variability. The finite element modelling [6,7] used in this study catches salient features of stress profiles measured by Mc Nally and al.
Thin hydrogel samples with a crack of 5 mm are used. The crack opens as a result of decreasing osmotic pressure in the experiments and in the simulation. The initial uniform stress distribution turns into a distribution with a decreased average stress level and a high stress around the crack tip. A decrease in osmotic pressure opens an existing crack in swelling materials independently from external mechanical load. Hence, disc degeneration causes the overall stress to decrease, while local stress around a crack tip increases. This mechanism may explain why damage in the disc is so poorly correlated with mechanical load [3] and why the degenerated disc is characterized by patent cracks [1]. The process of crack opening in the degenerating disc is comparable to the crack development in an aging oaken beam, while loosing its turgor.
Isolated arthrodesis of the subtalar joint has the advantage that it preserves some motion at the midfoot. In cadaveric studies, movement at the Talonavicular joint is reduced by up to 74% and at the Calcaneocuboid joint by up to 44%. This allows some midfoot flexibility, which would not occur with a triple arthrodesis.
There are several methods of performing a subtalar arthrodesis, broadly divided into extra or intra articular techniques, using structural or cancellous bone graft and a variety of fixation methods.
Earlier studies on primary arthrodesis have shown rate of non union from 0 – 6%. More recently, larger studies have reported higher rates of non union from 14 – 17%.
We present the results of 95 subtalar fusions performed with a standard technique, using one screw from the calcaneum to the talar dome, with 100% follow up.
Between 1993 and 2003 the senior author performed 105 subtalar arthrodeses. We performed a retrospective chart review. All patients with a primary subtalar fusion were included. All cases had been refractory to conservative therapy.
The senior author reviewed all patients until fusion had occurred or a diagnosis of nonunion was established. Fusion was diagnosed when the patient were pain free while fully weight bearing, with a clinically rigid subtalar joint and radiographs showing trabeculae crossing the arthrodesis. A CT scan was performed in all cases where nonunion was suspected, and the patient complained of persistent pain.
A total of ninety five subtalar arthrodeses were performed in ninety two patients. All were reviewed with clinical and radiological examination, until union had occurred or nonunion diagnosed. The average time to union was 5.0 months, range 3 – 12 months. The outcomes, graded using the method of Angus and Cowell, were 21 Fair, 7 Poor and 67 Good results
We aim to assess the outcome of ankle arthrodesis performed for painful osteoarthritis in the presence of a coronal plane deformity of 20 degrees or more. To our knowledge this is the first reported series of such a cohort of patients. We have a consecutive and complete series of 24 patients with 26 ankle arthrodeses which were all performed for painful osteoarthritis in the presence of large coronal plane deformity. These patients have a minimum of twelve months clinical follow up. The results showed a low non union rate of 8% (2 ankles). These have subsequently been refused satisfactorily, and were excluded from further analysis. The results of the remaining 24 ankles which united primarily show that they were very pleased with the outcome of their surgery. AOFAS scores were used to measure pain and function both pre operatively and post operatively. These scores showed large improvements for both pain and function, and had a high statistical significance (p< 0.0005). All patients improved in their walking distance and many patients reduced their need for walking aids. Stair climbing ability was also improved in some patients. It is recognised that an ankle arthrodesis usually relieves pain but does not result in a normal gait and full function. We feel that the high level of patient satisfaction in this series was due to the combination of deformity correction, restoring a functional foot position, and achieving a painless ankle. Arthroplasty of the ankle is a good procedure for relief of pain and restoration of function. However In the presence of a large coronal plane deformity ankle arthroplasty is known to fare badly with early failure. Therefore for patients with painful osteoarthritis and a coronal plane deformity of 20 degrees or more, we recommend ankle arthrodesis as the procedure of choice.
The standard protocol described by Ponseti was used for treatment.
Mean period of follow up was 12 months (6– 30 months).
Evaluation was by the Pirani club foot score.
Average number of casts required were 6.
Tenotomy was required in 80% of feet.
At the latest follow up approximately 15% of feet recurred following treatment and were managed surgically. Poor compliance was noted to be the main cause of failure in these patients. We have recently modified our splint and hope this will address some of the reasons for poor compliance. There was also a smaller subgroup of patients (approximately 5%) which failed to respond to the treatment regime and could not be brought to the point were tenotomy would be appropriate.
A visual analogue scale (VAS) was employed as a direct indicator of pain and indirectly, supplemental analgesic requirement. Measurements were made pre-operatively and postoperatively.
Age, weight and tourniquet times were compared with Mann Whitney U test and Chi-square. Pain scores and analgesic requirements were compared using ANOVA at a 5% significance level.
Arthrodesis of the ankle joint gives satisfactory short and medium-term results; however, in the longer term, it frequently leads to sub-talar and mid-tarsal osteoarthritis which is difficult to treat. Use of mobile bearings have significantly improved the results of ankle replacement. This a mid term follow up (1 to 5 years)of Buechel-Pappas ankle replacements performed by the senior author.34 total ankle replacements performed by one surgeon from October 1999 to May 2004 were reviewed retrospectively. Pre and post operative VAS scores, AOFAS scores were evaluated to find patient satisfaction and outcome. Tourniquet time as recorded in operation notes showed the learning curve for the procedure. Males : Females- 1:1.4. Mean age was 65 years (range : 33 to 83). Indication for surgery was primary osteoarthritis in 13, post traumatic arthritis in 14 and rheumatoid arthritis in 8. Average VAS score was 8.2 pre operative and improved to 2.0 at follow-up. AOFAS score improved from 39.1 to 72. Operating time averaged 113 minutes in 1999 and 85 in 2004. Significant complications were medial impingement (8) out of which 3 patients needed further surgery, intra-operative malleolar fractures (medial 4, lateral 1 and posterior 1, all healed successfully) and injury to cutaneous nerves (4) 3 patients had superficial infection which settled with antibiotics, but there were no cases of deep infection. 58 % were very happy, 32.5 % were happy, 9.5 % were not happy with the result. 2 patients had ankle fusion on the opposite side earlier, both were happier with the replaced side. Ankle replacements appear to offer a good alternative to fusion in selected patients. There is a significant risk of minor complications. Medial impingement may need further debridement at a later stage.
Arthritis in the ankle causes considerable malalignment in the anteroposterior plane. The DTL is not affected by the destruction of the tibiotalar joint and is independent of slight variations in the positioning of the foot and radiological magnification.
Radiographs of 200 cases of TAR were reviewed. The anterior and posterior outlines of the talus could not be seen in all cases (e.g. preoperative talonavicular fusion). As a result 49 cases of inflammatory arthritis (49 of 119) and 6 of osteoarthritis (6 of 81) could not be assessed.
There was a lesser tendency for subluxation in the inflammatory group of patients although the body of the talus itself was more deformed. The average preoperative value was ‘36.1’ and the post operative value was ‘38.9’.
This study does not refute the distal metatarsal articular angle as an entity, but does confirm the inaccuracy of extrapolating the DMAA from plain AP radiographs.
Patients who failed conservative treatment and underwent surgery had histological examination of achilles tendon and histochemical analysis for isomers of NOS (eNOS and iNOS) as a marker of NO production.
Histological examination did not show any difference in collagen synthesis or remodelling between the 2 groups and there was no evidence of stimulated wound fibroblasts in the GTN group. There was no difference between the groups in the expression of eNOS or iNOS.
A comparison was made between this device and the K9 walker which has been shown to be a liberating walking aid indoors. Tasks from activities of daily living, productivity and transfers were included. Assessment was undertaken by the Occupational Therapy Team.
The hands free crutch was also compared with non weight bearing using two crutches to gauge performance outdoors. Assessment of ease of use and safety was undertaken by the Physiotherapy Team.
Although speed was significantly greater (p< 0.0001.) using two crutches, the hands free crutch permitted safe outdoor mobilisation on even or uneven ground, up and down slopes with a gradient of 1 in 10 and up and down stairs. Good single leg stance stability was predictive of ease of use and safety for the hands free crutch.
Morton’s syndrome is an entrapment of a digital nerve between the metatarsal heads in the foot causing pain between the metatarsal heads. 41 subjects with signs and symptoms of Morton’s syndrome were prospectively examined with an ultrasound scan and the size of the bifurcation of the interdigital nerve was recorded if it was visible. Each subject completed a Visual Analogue Scale and short form McGill Pain Questionaire before an injection of local anaesthetic and corticosteroid was administered. The subjects were reviewed after 6 weeks and the pain scores repeated.
26 subjects had positive ultrasounds with a mean width of 5.1 mm, range 2.7–9.8 mm and 15 subjects had negative ultrasounds. Differences in mean ranks of VAS scores between the two groups were borderline statistically significant for scores before injection (p=0.064). Difference in mean rank of VAS score was significant after injection (p=0.013).
Differences in mean ranks of MPQ scores were borderline statistically significant for changes in scores (p=0.062). Difference in mean rank of MPQ score was significant after injection (p=0.007). None of the correlations between nerve width and any of VAS or MPQ outcome measures were statistically significant.
This study demonstrates that the larger the neuroma on the ultrasound, the more painful it is for the patient. This study suggests that patients who have a small or absent neuroma demonstrated on the ultrasound scan are more likely to have their pain reduced to an acceptable level with an injection of local anaesthetic and corticosteroid than those patients with a large neuroma. Ultrasound examination is a useful tool in the management of patients with Morton’s syndrome.
We performed two independent randomised controlled trials to assess the potential benefits of immediate weight-bearing mobilisation for Achilles tendon ruptures. The first trial on surgically treated patients provides strong evidence of improved functional outcome for patients mobilised fully weight-bearing after operative repair of their Achilles tendon rupture. The two cases of re-rupture in the treatment group suggest that careful patient selection may be required as patients need to follow a structured rehabilitation regime.
The second trial performed upon non-operatively treated patients provides only weak evidence of a functional benefit from immediate weight-bearing mobilisation. However, the practical advantages of immediate weight-bearing did not predispose the patients to a higher complication rate. In particular there was no evidence of tendon lengthening or a higher re-rupture rate. We would therefore advocate the use of immediate weight-bearing mobilisation for the rehabilitation of all patients with rupture of the Achilles tendon.
Claw toes are treated by a variety of soft tissue and bony proceduresbased on the severity of the deformity. We evaluated the results of Stainsby procedure for claw toes. This is a retrospective analysis of the results of Stainsby procedure for claw toes of the foot done by a single surgeon over a 10 year period. All patients who had claw toes,secondary to Rheumatoid and Non rheumatoid causes and treated by this procedure were included in the study. All the patients operated between Jan 1995 -Dec 2004 and who had minimum follow-up of 6 months after surgery were included in the study. Follow up evaluation was by clinical examination, review of case notes and telephone conversation.
42 patients underwent this procedure of which 38 were available for evaluation. Average follow-up was 43.5 months (6–110months). 26 rheumatoid and 21 non-rheumatoid feet were evaluated based on the AOFAS score. The mean AOFAS score was 76.5. The scores for the Rheumatoid and Non-Rheumatoid groups were 81.5 and 72.6 respectively.81% were satisfied with the result of the operation and 83% would recommend this surgery for friends and relatives. Six patients had superficial infection, 2 had broken k-wires, 2 had DVT, and 2 had recurrence of deformity.
We conclude that Stainsby procedure for claw toes is a procedure which has good results in the long term and can be taken up as a procedure of choice for severe claw toes.
One of the factors that influence the outcome after Achilles tendon rupture is gait abnormality. We prospectively assessed 14 patients with Achilles tendon rupture and 15 normal control subjects using an in-shoe plantar pressure measurement system. There was a significant reduction in peak mean forefoot pressure in the early period of rehabilitation (p < 0.001). There was a concomitant rise in heel pressure on the injured side (p=0.05). However, there was no difference in cadence, as determined by the duration of the terminal stance and pre-swing phases as a proportion of the total stance component of the gait cycle. The forefoot pressure deficit in the Achilles tendon rupture group was smaller when assessed six months after the injury but was still significant (p=0.029). Pedobarographic assessment of patients after Achilles tendon rupture confirms that there are marked abnormalities within the gait cycle. Rehabilitation programmes which address these abnormalities may improve outcome.
The Clinical assessment was based on modified American Orthopaedic Foot and Ankle Society’s hallux-metatarsophalangeal scale. The subjective assessment was done by a questionnaire and radiological assessment was done by using digital radiographs.
Lumps of the foot present relatively infrequently to the orthopaedic service. There have been very few published studies looking at presenting characteristics or the differential diagnosis of such lesions. We report our experience of foot lumps treated surgically looking at the patient demographics, presenting characteristics, diagnoses encountered and the diagnostic accuracy of the surgeon. All patients who underwent excision or biopsy of a foot lump over a period of 4 years were studied; 101 patients were identified. Average age was 47.3 years (range 14–79); there was a significant female preponderance with 73 females and 28 males (p< 0.0001). Pain was the single most common presenting complaint followed by footwear problems. Only three patients attended because of cosmetic reasons and neurological symptoms were very rare with only one patient complaining of paraesthesia. Certain lesions were more commonly encountered in specific zones of the foot. 32 different histological types were identified, ganglion cysts were the most commonly encountered lesions and there was only one malignant lesion encountered in this study. Only 58 out of the l01 lumps were correctly diagnosed prior to surgery.
We have shown that there are a wide variety of potential diagnoses, which have to be considered when examining a patient with a foot lump. There is a low diagnostic accuracy for foot lumps and therefore surgical excision and histological diagnosis should be sought if there is any uncertainty.
The patients’ overall satisfaction with the result of their foot surgery was determined using a Likert scale and the results can be seen in Table 1.
Patients in the podiatric surgical group were significantly more satisfied with the result of their foot surgery than those in the orthopaedic group (p< 0.008; Mann Whitney U test).
Similar statistically significant differences were also seen between the two groups relating to patient satisfaction with their pre and post-operative consultations and information concerning their proposed surgery and its outcome.
CT- scan as an management tool is being used extensively in managing calcaneal fractures. We set out to see if a CT-scan makes any difference to the management plan as obtained by looking at the plain radiograph. We also looked at the correlation with the actual management.
The foot pressures were measured in Kilopascals(Kpa). Independent T-tests was used to compare mean pressure distributions in the six anatomical divisions. We found the mean pressures through the 5th metatarsal head – 217(t=−2.32,p< 0.05) and midfoot 94(t=−3.17, p< 0.05), were significantly higher when compared to pressures in normal subjects (table 1).
The aim of the current study is to compare the compression forces achieved by mini compression screws on cortical and cancellous bone models.
Proximal fifth metatarsal fractures distal to the tuberosity, also known as Jones’ fractures, are troublesome fractures to manage with a high incidence of delayed union and nonunion.
We conducted a retrospective study of 32 patients with fractures of the fifth metatarsal distal to the tuberosity over a three year period. The aim was to assess healing with non-weight bearing and variations of weight bearing mobilization including minimal, partial and full weight bearing. This is one of the largest reported series of such fractures. These fractures were classified as acute fractures (14 fractures), fractures with features of delayed union (15 fractures) and fractures with features of nonunion (three fractures) at presentation according to the radiological classification used by Torg in 1984. These patients were treated in a plaster cast and mobilised either non-weight bearing or with variations of weight bearing. These patients were followed up for a mean of 16 months.
Our findings correspond with those observed by Torg and we describe a correlation between the radiological appearance of the fracture at presentation and the clinical course. Prevailing guidelines for the management of these fractures are ambiguous. A standardized classification is important because there is great variability in the types of fractures and appropriate treatment. It is important that radiological features are correlated with clinical features and appropriate treatment instituted. The treatment of choice for acute fractures is immobilization of the limb in a below-knee non-weight bearing plaster for 6 to 8 weeks. Fractures with delayed union may eventually heal if treated non-operatively, although this may take up to 20 weeks. An active athlete will benefit from early surgery. Fractures with symptomatic nonunion require surgery.
Morton’s Metatarsalgia is a painful condition and can often be debilitating. The value of surgical exicion has been doubted due to low success rate of surgical intervention.
Shape memory phenomenon whereby the metal changes its characteristics depending on the ambient temperature it is exposed to is well described in the metallurgical literature. In cold conditions (0–5° C) the alloy becomes plastically deformable and its shape can be changed at will, but would rapidly regain its original shape and strength at higher temperatures. This study assesses the effectiveness of shape memory staples as a method of internal fixation in foot and ankle surgery.
All patients who underwent foot and ankle surgery in which Memory® staples were used for fixation were included in the study. The patients were evaluated with regard to period of immobilisation in cast, period of restricted weight bearing and time to radiological joint fusion or union of osteotomy.
Memory® staples had been used in a total of 40 procedures; 13 procedures (6 MTPJ fusions, 7 Akin osteotomies) were done in the forefoot while the rest were carried out in the mid or hind foot. Bone grafting was used only in one hind foot arthrodesis. A strong arthrodesis or union was achieved in all the patients. The average time to fusion was 7.2 weeks (range 6–12) with an average period of immobilisation of 4.3 weeks (range 0–12). The average time to full weight bearing was 5.2 weeks (range 0–6). Breakage of the staple was noticed in one patient but the joint went on to unite satisfactorily. Staple back out or displacement was not noticed in any of the cases.
The early experience with the use Memory® staples in foot and ankle surgery is encouraging; we did not encounter any technical problems and there is a suggestion that these implants may reduce the time to fusion/ healing thereby reducing the recovery time following foot and ankle surgery.
Claw toes are treated by a variety of soft tissue and bony proceduresbased on the severity of the deformity. We evaluated the results of Stainsby procedure for claw toes. This is a retrospective analysis of the results of Stainsby procedure for claw toes of the foot done by a single surgeon over a 10 year period. All patients who had claw toes, secondary to Rheumatoid and Non rheumatoid causes and treated by this procedure were included in the study. All the patients operated between Jan 1995 -Dec 2004 and who had minimum follow-up of 6 months after surgery were included in the study. Follow up evaluation was by clinical examination, review of case notes and telephone conversation.
42 patients underwent this procedure of which 38 were available for evaluation. Average follow-up was 43.5 months (6–110months). 26 rheumatoid and 21 non-rheumatoid feet were evaluated based on the AOFAS score. The mean AOFAS score was 76.5. The scores for the Rheumatoid and Non-Rheumatoid groups were 81.5 and 72.6 respectively.81% were satisfied with the result of the operation and 83% would recommend this surgery for friends and relatives. Six patients had superficial infection, 2 had broken k-wires, 2 had DVT, and 2 had recurrence of deformity.
We conclude that Stainsby procedure for claw toes is a procedure which has good results in the long term and can be taken up as a procedure of choice for severe claw toes.
Thirty patients underwent tibio-talo-calcaneal fusion using an interlocking arthrodesis intramedullary nail device with locking screws. Although the nail is described as being stiffer in flexion, rotation and cantilever bending it was noted that the placement of the locking screw holes were not sufficiently in-tune with the variations found in nature. The placement of the holes and locking screws with relation to the heights of the talus and calcaneum were measured on post operative xrays and conclusions drawn from the variations found. It was felt that the intramedullary nail is a good device when used for tibio-talo-calcaneal fusion but that the design could be improved in order to improve patient outcome.
Ankle replacements appear to offer a good alternative to fusion in most arthritic conditions. Use of mobile bearings have significantly improved results of ankle replacement. These have a significant minor complication rate including nerve injury, fractures. One of the significant complications noted in our series was medial impingement. 34 Buechel-Pappas total ankle replacements performed by the senior author from October 1999 to May 2004 were reviewed retrospectively. Mean follow up of 2.8 years. 8 patients reported medial impingment symptoms at follow up. 3 patients underwent repeat surgery for this problem. One patient underwent arthroscopic debridement of scar tissue and impinging bone by another surgeon which gave good symptomatic relief. Two other patients had tibialis posterior tendonitis and underwent surgical decompression of the tendon. Both were found to be having degenerative tendons with partial tears. We discuss the findings, literature review and other complications of ankle replacements as well. Whether medial impingement is due to implant design or inherent pathology of ankle has to be studied further. Other implant designs like Agility may treat arthritis in medial and lateral gutters but can still cause soft tissue impingement. Whether these are due to implant design, residual arthritis in medial recess or soft tissue pathology is uncertain. This may be caused by the cylindrical shape of talar component (the physiologic talus has a cone shape with smaller radius on medial side). This has not been proven yet, but has been addressed in newer designs like Salto and Hintegra prostheses.
Background: Since 2003 we have offered correction of bilateral hallux valgus to suitable patients as a daycase but there is nothing in the literature to support this as safe practice. Two published series support unilateral hallux valgus surgery as a daycase. We prospectively evaluated 30 bilateral daycase patients assessing complications and overall satisfaction rating.
If this and other treatable causes have been excluded, treatment with the regime described may give good symptomatic relief in the short to medium term.
Subtalar joint stiffness is an under recognized complication of ankle fractures. We set out to objectively measure its prevalence and impact on Activities of Daily Living (ADL).
60 ankle fractures included in study. All patients had contralateral normal ankle. M:F=21:39 Average age: 36 (19 – 84) Weber: A B C 21 27 12 27 patients underwent ORIF (12C + 15B) 39 patients had plaster casts for between 2 and 6 weeks. (27B + 12C) Postop regimes included early mobilization and POP application (AO recommendation) Weber A (21) treated symptomatically. Examinations for study at 3/12 and 6/12 post injury. Subtalar and ankle movements were assessed by the same examiner (as per Hoppenfeld) Subjective questions about subtalar stiffness and their impact on ADL were asked.
At 3/12, 56 patients (17A + 27B + 12C) had subjective and clinical impairment of subtalar movement. 32 patients (2A + 20B + 10C) had moderate to severe impairment (>
30%) At 6/12, 42 patients (9A + 23B + 10C) had subjective symptoms and clinical impairment of subtalar function. Of these, 26 (0A + 18B + 8C) had >
30% impairment vs. controls.
The recognition, investigation and management of osteoid osteoma has been well documented. Treatment can either be medical or surgical, studies have shown both options to have almost equal long term outcomes. However only surgical treatment involving complete excision of the lesion allows for confirmatory tissue diagnosis of osteoid osteoma especially important in cases where symptoms and signs are atypical. Several methods of surgical treatment with varying degrees of success have been described in literature. Here we describe a surgical techniques for the treatment of osteoid osteoma which enables removal of the lesion in a precise manner using a precision bone graft trephine with minimal excision of bone. This technique will be very useful in the excision of lesions in areas in which excessive excision of bone can lead to an unstable bony structure which can predispose to fracture. To our knowledge this surgical technique in the management of osteoid osteoma has not been described in the literature.
We present our results with a modified Mann-Thompson procedure in 47 patients (86 feet). Minimum follow up was 24 months.
All patients had moderate to advanced forefoot deformities.
M:F=12:35 43/47 bilateral Simultaneous procedures in bilateral cases. Popliteal block analgesia used routinely.
Medial incision centered on MTP1 joint. Minimal bony and soft tissue resection. Fixation carried out with staples (78 feet),K-wires (8 feet) Transverse incision centered on the lesser MTP joints made. Combination of soft tissue release, lesser MT head resection in cascade fashion from dorsal distal to proximal plantar performed. Lesser toe deformities treated by a combination of closed osteoclasis, soft tissue release and bony resection. Transarticular K-wire fixation then performed for all lesser toes. Bulky postop dressing and post op shoes used. Immediate FWB permitted. Transarticular K-wires removed at 4/52.
AOFAS Forefoot Scores assessed at preop,6/12,12/ 12,and24/12. Subjective patient assessment of procedure requested. Average AOFAS scores improved from 37to72(67 – 84) 40 patients extremely pleased with the results. 5 patients pleased with reservations and 2 patients disappointed with the outcome.
3 superficial wound infections 2 metal work related problems 2 early loss of lesser toe correction 3 late deformities of lesser metatarsals requiring surgery
Primary care trusts (PCTs) are encouraged to create musculoskeletal services to improve access and reduce pressure on orthopaedic clinics. Previous reports have suggested problems can arise.
A PCT with a population of 100,000 launched a musculoskeletal service in July 2004. The foot and ankle component was in partnership with the local secondary care foot team. Treatment and referral guidelines were agreed. The PCT staff reviewed GP referrals to orthopaedic clinics. They could forward letters to the acute trust orthopaedic department or initially treat the patients in primary care.
We audited referrals from October-December 2004, allowing 3 months to establish the service and 6 months follow-up.
617 orthopaedic referrals were received, including 123 (19.9%) adult foot and ankle problems. 82 patients were treated initially in primary care: 54 by the podiatrist, 20 by the physiotherapist and 8 by the specialist GP. Commonest problems were metatarsalgia (12), hallux valgus (10), Achilles tendonopathy (9), plantar heel pain (9), generalised foot pain (8) and arthritis (6). The commonest intervention was attendance at a physiotherapy programme (26) followed by advice (22), usually about shoewear, insoles (14) and injections (8). Ten patients were referred to secondary care after initial treatment in the community, all in accordance with guidelines; four were listed for surgery. Four patients failed to attend and information was missing on six.
31 referrals were sent directly to secondary care, 29 of which were according to guidelines. 9 were offered surgery, 9 had other specialist care, 6 required services which could not be accessed directly by the PCT team and 3 failed to attend.
Primary and secondary care can work together successfully to deliver services for patients with foot and ankle problems, though waiting time remains a challenge.
Arthrodesis of 1st MTP joint is a reliable procedure for hallux rigidus. We have studied the effects of first MTP joint arthrodesis on activities of daily living and leisure activities
We evaluated pre op scoring for pain, walking distance, walking up hill – stairs, foot wear, return to leisure activity and work, chronicity of symptoms, associated symptoms, radiological appearance pre op, post op and at radiological fusion and complication rate.
All patients were followed up.
The patients were contacted with questionnaire to evaluate the function after the fusion.
The patients were asked whether they would participate in the foot pressure study; which was done with the help of podiatrist at same trust.
We have tried to correlate the functional outcome and its relation to foot pressure.
We present our results in 89 consecutive patients (138 feet), minimum FU of 24/12.
Contraindications included abnormal DMMA, significant 1st MTP arthritis, hypermobility of 1st MTC joint, revision surgery.
All patients underwent a 3-in-1 procedure with soft tissue release in 1stwebspace, medial bunionectomy with capsulorraphy and basal crescentic osteotomy.
A 25 mm blade on oscillating driver was used. Fixation was staples(70%),screws(20%),K- wires(10%).
Post op, PWB, progressing to FWB at 3/52.
AOFAS forefoot scores at pre-op, 6/12, 12/12 and 24/12.
Weight bearing radiographs obtained at pre-op, 3/12, 12/12.
M:F=19:70 Age 31–79 (Mean 64) 89 patients, 138 feet AOFAS scores improved from average 42/100 preop to 76/100 at 6/12. Radiographic correction excellent in78% of patients. 74 % of patients extremely satisfied,15 %satisfied,11 %unsatisfied with outcome.
Nonunion=2 Infection=2 superficial,1 deep Recurrence of deformity at 6/12 = 2 12/12 = 2 Transfer metatarsalgia M2 due to overriding of distal M1=3
We present our four-year experience with a new minimally invasive method for ambulatory treatment of lumbar discal herniation: micro video endoscopic dissectomy.
Video endoscopic surgery associates microsurgical procedures similar to those used in conventional surgery with a very precise technique. This method was used for 50 patients presenting lumbar disc herniation diagnosed with magnetic resonance imaging using the MacNab criteria, placing priority on the neurological risk of sensorimotor deficit.
Clinical outcome was also evaluated with the MacNab criteria. These patients were able to walk early, resumed work rapidly, and had little lumbar pain and few complications.
Exact knowledge of the site of the lesion, and a better understanding of the traumatic mechanisms have led to a major improvement in the surgical approach used for the treatment of thoracolumbar fractures.
The first reports of a combined anterior and posterior approach recommended a two-week recovery period between the two stages.
It was observed however that the rate of complications was higher and that at the time of the second stage patients had a poor nutritional status which increased the rate of mortality. It was also remarked however that a sequential approach performed on the same day could be achieved.
Recently, the simultaneous anterior and posterior approach was reported by Farcy and others. Their preliminary results indicate that in terms of duration of anesthesia, blood loss, and complications, the simultaneous method is better than the sequential method.
The purpose of our work was to report an analysis of the mechanical and biological benefits of the simultaneous approach for the treatment of thoracolumbar spinal fractures.
Material and method: Among a series of 485 hips with LPCd, 148 (30.5%) with massive involvement were identified. Ninety-six (64.9%)severe forms were analyzed at the end of growth. Magnetic resonance imaging, scintigraphy and arteriography were used to better assess the femoral head and identify hips at risk. These hips were treated surgically: Salter osteotomy (SA), triple pelvis osteotomy (TO), or varus osteotomy (VA). Three groups of infants were identified according to age at diagnosis of LPCd: less than 6 years, 6–9 years, more than 9 years. Outcome was considered good (Stulberg 1 and 2, Mose good), fair (Stulberg 3, Mose fair), or poor (Stulberg 4 and 5, Mose poor).
Material and results: The heel was amputated in four children (lawn mower or bicycle spoke accidents). Cover was obtained with a sural (three first-intention) neurovascular island flap with a distal pedicle. The long-term assessment evaluated function as well as residual growth of the calcaneum. Four lawn mower accidents produced lesions involving the toes and the mediotarsal area which did not require emergency flap cover. Dorsal retractions occurred in all four cases and progressed secondarily, later requiring a good quality skin flap and dorsal release. In five children lesions of the toes, forefoot, or the entire foot occurred in five children whose foot was crushed under car (or truck) wheels or was injured during fall from a wall. In these children, the urgent or secondary skin problems predominated in the dorsal area and required a variety of flaps.
Material and method: We have treated 62 cases of Ewing tumor of the iliac bone since 1976, 36 males and 25 females, mean age 16.5 years (range 4 – 47). Thirteen patients presented primary metastases. Mean tumor size, measured by digital imaging, was 729 cm3. Adapted chemotherapy was given in all cases. Local treatment included exclusive radiotherapy in 20 patients, radiochemotherapy in 15 and exclusive en bloc extratumoral resection in 27.
Case reports: Case n° 1 was a 16-year-old girl who presented a Ewing sarcoma involving the left iliopubic ramus. No other foci could be identified on the plain x-rays, scintigraphy and bone computed tomography. Preopeartive magnetic resonance imaging revealed a metastatic focus in the neck of the homolateral femur. The two foci were resected after preoperative chemotherapy: resection of the left hemi-pelvis and resection of the upper potion of the femur with replacement with a pelvic prosthesis and and massive prosthesis for the proximal femur. Eight years later, the patient has remained in complete primary remission, consulting for orthopedic gait problems related to prosthetic loosening. Case n° 2 was a 13-year-old boy who presented an Ewing sarcoma of the upper tibial metaphysic. Preoperative magnetic resonance imaging revealed three other metastatic localizations in the homolateral femur. Bifocal resection of the tibia and the femur was performed with implantation of an active growth prosthesis. Chemotherapy was continued. Seven years later, the patient remains in primary complete remission. Lengthening the prosthesis has enabled equivalent growth for the two limbs. The patient has a normal life style excepting contact sports which are prohibited. Case n° 3 was a 17-year-old boy who presented a voluminous Ewing sarcoma of the right pelvis. Search for extension revealed a unique metastasis in the fourth lumbar vertebra. The patient was given preoperative chemotherapy before resection of the pelvic tumor then two months later resection of the vertebral metastasis. The patient died 4.5 years later from a traffic accident. He had remained in complete remission.
Discussion and conclusion: These three cases of complete long-term primary remission of patients with primary bone metastases show that like other bone sarcomas, eradication of all recognized bone metastases is essential for the prognosis of Ewing sarcoma.
all three cuts are performed via a single intra-pelvic approach; For severe extreme dysplasia (Hip Study Group classification), a two-thirds triple osteotomy is performed (original technique). Currently the best indication appears to be a young patient (less than 30 years) with moderate to severe dysplasia, without intra-articular suffering and without any sign of early stage joint degradation.
The femoroacetabular conflict is a recognized cause of hip pain in young patients. It is associated with rim tears. Two types of conflict have been described: impingement due to retroversion of the acetabulum and «cam effect» associated with insufficient head/neck offset. A recent subject of debate has been isolated treatment of the rim tear without treating the often unrecognized bone anomaly. The purpose of this study was to assess short-term outcome after surgical remodeling of the head/neck junction for the treatment of femoroacetabular conflicts.
Osteoid osteoma is a benign bone tumor usually observed in children and adults, generally in the femur or tibia. Pain relief with aspirin is a classical clinical characteristic. Computed tomography is the exploration of choice providing reliable diagnosis. Cure can be achieved with surgical resection. We present an exceptional case of osteoid osteoma located in the patella.
correct offset of the femur, measured as the distance between the center of the head and the anatomic axis of the shaft; offset of the center of rotation, measured as the distance between the center of the head and the pubic symphesis. Addition of these two offsets gives the overall offset. The purpose of this work was to analyze postoperative offset after standard total hip arthroplasty as a function of the preoperative head-shaft angle.
Radiographically five prostheses were unstable with potential loosening (3 tibial and 2 talar components), one presented varus misalignment, and the others were considered correct. Moderate to severe intra-articular osteophytes were noted in 11 ankles. Three presented an undetermined defect image in the tibia.
1 (9.6%) and in 4 (1.7%) in group 2. The difference was significant. Presence of a history of dystrophy was significantly associated with development of dystrophy (RR=10.4). A psychological context appeared to increase the risk of dystrophy (RR 2.6) but did not reach significance. There was no statistical relationship with age, gender, duration of tourniquet, type of disease condition, or surgical procedure performed.
The prevalence of scoliosis deformations was higher in patients aged over ten years (p< 0.01). The prevalence of scoliosis was greater in female patients. Patients with BMI< 25 had a significantly lower risk of scoliosis. Treatment with growth hormone was associated with a significant decrease in risk of scoliosis. Among scoliosis patients, ten had a main curvature < 15° and were monitored. Eleven had a curvature > 15° (31±11°) and were treated with a corset. Five had a curvature > 50° and trunk imbalance and were treated surgically. Four of these patients developed serious complications.
In the United States and other countries, one of the primary causes of medical errors in pediatric patients is the misdiagnosis of hip dysplasia. Thred diagnostic forms are described in children.
We consider that the following diagnostic algorithm should be applied: clinical assessment of both hips at birth, repeated clinical examination once a month to six months, ultrasonography from the sixth week to the fourth month performed by an experienced pediatric operator, in the event of doubt or unavailable programmed controls, radiography of both hips at the fourth month.
We present nine cases of hip dysplasia which illustrate this diagnostic approach.
We present the case of an 8-year-old child with congenital multiple arthrogriphosis. The child had never walked and presented 80° fixed knee flexion and hips in a position of hyperrotation which enabled him to sit in a Buddha position. Talipes varus equin with non-reducible supination, compromised by rigid stiff upper limbs was resolved by multiple procedures and immobilization with an external fixator.
4. Nerve repair was required for 11 cases: 5 by direct suture and 6 with grafts. Resection was impossible for 4 tumors treated by neurolysis, decompressive epineu-rotomy, biopsy and interfascicular dissection.
The operation, described by Castle, consisted in subtrochanteric resection and suture of the quadriceps muscle around the femoral cut. The capsule detacted from the femur was closed around the acetabulum. The abductors were sutured between the shaft and the acetabulum in order to ensure interposition of enough soft tissue. An external fixator (Orthofix®) was installed for 90 days. This method has the advantage of producing the necessary distraction while allowing immediate mobility (hip extension flexion) and good balance in the sitting position as well as better perineal hygiene compared with the preoperative situation.
At six months, there was a clear clinical improvement in terms of pain relief, tolerance to the sitting position, and perineal hygiene with a significant increase in joint motion (flexion, extension, abduction). Proximal migration of the femur was observed in one case after removing the external fixator. There were no cases of recurrent adduction deformity, stiffness or bone hypertrophy.
IKDC score was established preoperatively and at 6 and 12 months. An arthroscan was obtained at six months.
an abundant vascular network, presence of cells expressing transcription factor CBFA1, very few inflammatory CD14+ cells (macrophages), an extracellular matrix positive for type I collagen.
evaluate new therapeutic strategies for bone regeneration in conditions close to clinical situations, study the role of the membrane in bone repair.
The presence of a pseudosynovial membrane might:
be a barrier against the diffusion of bone morphogenetic proteins outside the lesion and potentially be a reservoir of stem and vascular cells which could be useful for new technologies.
cut parallel to the posterior bicondylar line (BCL), 3° external rotation, spacer method, application of the formula: rotation = 1° + space in extension/2.
dictated by the congruence of the polyethylene in an ultracongruent plateau; completely free, depending solely on the ligament structures in a self-aligning prosthesis; the consequence of a compromise between the two, using a semi-constrained prosthesis. With the OMNIA system, the unique femoral piece can be combined with a Wallaby ultracongruent plateau (WUC), a self-aligning mobile plateau (SAL), or a semiconstrained plateau with preservation of the posterior cruciate ligament (Wallaby 1, W1). A comparative study of these three prostheses was performed to evaluate the influence of femorotibial rotatory constraint on patellar stability.
In the international literature, the rate of recurrence after conservative treatment of traumatic anterior dislocation of the shoulder joint is high. Rates are highest in young subjects and violent sports. Recent publications report a lower rate of recurrence after immobilization in external rotation but with a short follow-up and in heterogeneous groups where contact sports were not individualized.
Between August 1989 and April 1997, we conducted a prospective study to assess outcome in contact sports athletes aged at least 30 years (arthroscopy, 2001) Comparing the results of surgical and non-surgical treatment showed excellent or good outcome in 96% of the surgery group and in 94% of the non-surgery group.
Later publications showed that chronic disease is an important negative factor for bone and cartilage tissue quality at repair.
Between August 1989 and March 2005, we have performed 97 first-intention arthroscopic repair procedures in contact sport athletes and have obtained anatomic repair more easily with better quality tissue and better outcome with a lower rate of recurrence as well as more rapid resumption of training.
Lesions of the fibrocartilaginous triangle of the carpus (FCTC) and lunatopyramidal (LP) instability are the most frequently treated situations involving ulnar instability of the wrist. Most publications to date have examined results obtain for the treatment of isolated lesions, few have reported associated injuries. Outcome could be better in terms of pain relief: 25–64% of pain-free results for the treatment of FCTC and unpredictable results for the treatment of LP instability.
Considering the column theory proposed by Navarro-Taleisnik we have developed a concept based on fixation of the pyramidal and an adaptation of the Mayfield lines (where kinetic energy is considered exclusively on the ulnar side); we present here what we call the «peripyramidal ring lesion».
In our series of surgical cases, pain-free outcome for combined ulnar lesions treated as FCTC lesions was achieved in 48% of cases. For cases treated as LP instability, the rate was 71.4%. Many combinations are underdiagnosed: pyramidal-median hamate, pyramidal-pisiform. By treating these combined lesions we have increased the rate of excellent results from 64% to 91% for FCTC and obtained 86% pain-free wrists for LP instability.
We distinguish three phases of rheumatoid arthritis:
the phase of hypertrophic synovitis; the phase of joint disorganization; the phase of joint destruction.
During the synovitis phase, expansion of the synovial membrane leads to changes in the neighboring tissues with distension of the joint capsule and ligaments and destruction of the cartilage tissue. Tumefaction and increased volume of the tenosynovial membrane interferes with tendon gliding, giving rise to limited motion and pain. As the phase advances, tendon tears may appear because of invasiveness of the tenosynovial tissue. Surgical treatment during the synovitis phase can include synovectomy or tenosynovectomy.
During the phase of joint disorganization, capsule and ligament distension induce the deviations and instabilities characteristic of rheumatoid arthritis. The basic objective of surgery is to realign the joints and restore the anatomic relations.
Cartilage is lost during the phase of joint destruction and surgical reconstruction is the only option (arthroplasty, arthrodesis) but with inevitable loss of function.
Wrist lesions should be treated before more distal joints. The principle of repairing the most proximal joint first applies for the entire upper limb.
For the dorsal aspect of the fingers, injury to the extensor system gives rise to three characteristic deformities: mallet finger, swan-neck finger, and button hole finger. A detailed knowledge of the extensor system is needed to better understand the origin of these deformations. Briefly, the extensor system is composed of three tendon elements: the lateral bands, the median bands and the common tendon, and two retinacular elements: Landsmeer’s oblique retinacular ligament and Cleland’s transverse retinacular ligament.
The objectives of surgery are:
achieve pain relief; improve function (motion, stability); prevent disease progression; and improve the aesthetic aspect.
Results: For the patients with the shoulder triad, outcome was excellent to satisfactory in all, with frontal and vertical elevation greater than 90°, nearly normal rotations, and acceptable force and range of motion for daily, occupational and sports activities. The patients with dead shoulder syndrome were a more heterogeneous population. Clinical outcome was less satisfactory although there was a real improvement in range of motion. Occasional pain was reported and some of the patients were satisfied.
Conclusion: Combined lesions of the shoulder create a difficult diagnostic and therapeutic situation. As when occurring alone, it is important to recognize injury early in order to adapt treatment to achieve functional improvement.
Progress in diagnostic tools had enabled a more precise assessment of fractures of the talar neck. We discuss classifications based on magnetic resonance imaging which have provided an important aid for preoperative planning.
We recall here changing attitudes concerning the treatment of these fractures as well as their classification based on surgical anatomy. Details of the surgical technique are also discussed and the postoperative phase described.
This work is completed by comments on complications we have observed in our experience, focusing on the social cost of these complex fractures, their treatment and outcome, and the unpredictability of the disability caused by fractures of the talar neck, even after perfect reduction.
In this article, a definition of metatarsalgia is followed by an analysis of factors involved: biomechanical alterations, diseases of the forefoot and general diseases with an impact on the forefoot.
This is followed by a brief recall of the historical background and a description of the pathological anatomy and determining anatomic and biomechanical factors.
The frequency, symptoms and differential diagnosis are discussed together with the clinical, radiological, ultrasonographic and magnetic resonance imaging findings.
Conservative and surgical treatments are proposed together with a detailed description of the procedures and the supramalleolar anesthesia used in our department.
uncoated implants should be abandoned; HA resurfacing does not reduce the rate of revision and can be associated with a higher rage of osteolysis; there is no advantage between screw fixed or press-fit cups as long as the cup has a quality resurfacing; there is no real difference between straight and anatomic pivots except that intraoperative fracture can be lower for the straight implants.
The diagnosis and preoperative planning for fractures of the calcaneum are based on magnetic resonance imaging. This leads to a pathological classification used to predict the prognosis and detail operative techniques. Complications of this technique are discussed together with the social impact of this complex fracture.
This work was supported by work on cadaver specimens measuring the step by step effect of ligament release.
The resolution of the reformated digital images enabled real time screen display of instrument movement at a resolution which enabled pin insertion in the scaphoid axis. The length of the perforated screw inserted percutaneously over the pin was measured on the screen.
In adults, supracondylar fractures of the femur occur in two age groups, young subjects victims of high-energy trauma often with associated injuries, and old subjects, generally women, victims of low-energy trauma with no other injury.
The basic problem is the difficult reduction and stabilization. Once this has been achieved, the objective is to avoid knee stiffness, nonunion, and a misaligned callus.
The goal of treatment is to restore anatomic configuration, achieve stable fixation, and allow early mobilization.
Based on work by Seligsson and Lannacone in 1993–1994, we began treating these fractures with retrograde centromedullary nailing. Our first report of 17 cases was published in 1999. We have analyzed 42 cases with mean three year four months follow-up: 40 healed at 74 days on average, with only two cases of nonunion. Knee flexion was greater than 80° in 36 patients and there were no deformed calluses. The positioning technique is easy, biological, and totally safe. There are few complications and outcome is good.
Retrograde nailing is indicated for closed or open Gustilo I-II fractures, group A and C1-2 fractures in the AO classification.
Contraindications are open Gustilo III fractures and AO C3 fractures, or fractures with a very low supracondylar localization.
Digitalized computed tomographies of the carpometacarpal joints magnified threefold were fed to a Stratasys® machine which created a rapid «polystyrene shock» prototype of the first and second metacarpals as well as the trapezium and the trapezoid. After a preliminary study of the behavior observed with various materials, rubber with known consistency was used to simulate the different ligaments. The first metacarpal was submitted to six movements in defined directions starting from the neutral position (in accordance with Pieron, 1973). Ligament lengthening observed for each movement from the resting position of the first metacarpal was used to define the direction producing the greatest lengthening. This lengthening was measured directly with a graduated ruler under 2.5 x optical magnification.
Selective injections of methylene blue were used in the main gracilus pedicle; the area of skin colored was then measured (greatest and smallest diameter) for computation of the surface area using an imaging software. Selective injection of a colored latex fluid enabled description of the perforating vessels between the muscle body and the skin cover.
Cases of neglected fractures of the radial cup without injury to the distal radioulnar joint and cases of polyarthritis treated by double resection radioulnar and Sauvé-Kapandji) presenting good longitudinal stability were studied.
The main fibers are: the intermediary descending fibers and the proximal ascending fibers. They insert on the interosseous tubercle of the radius, a constant eminence situated on the medial border of the radius 8.4 cm from the elbow.
The thre groups of descending fibers limit proximal translation of the radius. The proximal fibers can limit excessive distal translation. The proximal and distal ascending fibers limit distal translation of the radius. A full thicknes tear of the anterior plane is necessary to achieve proximal displacement. Longitudinal stability is maintained in neglected fractures of the distal without rupture of the interosseous membrane and in operated polyarthritis with resection of the two radioulnar joints.
comminution of the dorsal wall; anterior wall damage deeper than 2 mm; intra-osseous cavitation due to a crushed medullary canal. Two other instability factors were observed: comminution of the medial wall of the radius; free styloid process disconnected from the articular fragment. The classification system was as follows.
Fractures without dislocation. Fractures with dislocation 1) extra-articular: ligamentotaxy + pinning + cast or ligamentotaxy + pinning + radioradial fixator. 2 intra-articular.
Type I: without comminution of the medial wall, styloid process connected to the articular fragment: ligamentotaxy + pinning + cast or ligamentotaxy + pinning + radioradial fixator.
Type II: with comminution of the medial wall, «free» styloid process: open surgery (reduction and stabilization), bone grafts for osteodesis or osteosynthesis, plating + bone grafts (as needed) with a metacarpal radio-radial fixator.
Type III: complex comminutions, radioradial fixator, 2nd metacarpal (formal indication).
implantation of the cup in the paleoacetabulum; screwed autograft harvested from the femoral head to fill the bony defect; implantation of an anatomic stem, without cement but with HA-coated shaft.
Between 1993 and 2001, 61 patients underwent surgery for Crowe III or Eftekhar grade C hips (n=45) and Crowe IV or Eftekhar grade D hips (n=16). Mean patient age was 42 years. Prostheses inserted via the trans-trochanteric approach with femoral shortening osteotomy and cementing developed complications related to the trochanteroplasty: nonunion of the greater trochanter (n=6), functional impairment (n=2), infection after bursitis on suture and secondary necrosis (n=1). Because of these complications we adopted the triple femoral osteotomy technique for shortening, derotation and press-fit femoral implants. Between 2001 and 2005, eight Eftekhar D hips were treated with this technique. Locked non-cemented femoral prostheses were inserted. Pre- and postoperative clinical assessment was based on the Postel-Merle-d’Aubigné score. For the cup, the technique remained unchanged, with cemented implants. The lengthening obtaine varied from 3.5 to 5.5 cm with no cases of sciatic palsy. There has been no case of prosthesis dislocation.
quantification of uptake: uptake two-fold greater on the injured side is a sign of «certain» fracture; software superposition of the scintigraphic image and the radiographic image used to localize the bone fracture.
When patients with anterior impingement were questioned, 80 were found to have a history of cervical pain which was confirmed radiographically and/or on computed tomography (CT). Physical examination of the cervical spine revealed pain at pressure on the anterolateral aspect of the C4, C5, and C6 vertebrae, always homolateral to the impingement. Search for this sign has thus become part of our routine examination and, according to Maigne, confirms the vertebral origin of peripheral pain. We found it to be absent in anterior impingements caused by trauma in young subjects, and to be inconstant in traumatic anterior impingements observed in patients aged over 55 years. After cervical arthrodesis for cervicobrachial pain, we observed five cases of progressive anterior impingement requiring decompression. In their series of 76 cervical arthrodeses for cervicobrachialgia, Hawkins et al on observed 13 cases of proven anterior impingement. They concluded there must be a relation between these two conditions. Golg et al. provided a decisive contribution to the theory when the discovered that in anterior impingement patients, rotator cuff muscles exhibit specific histological markers of muscle denervation.
All patients were evaluated prior to surgery. The patients with coexisting inflammatory disease or peri-prosthetic fracture were also evaluated.
A hip was diagnosed as infected on the basis of positive intra operative microbiology samples three or more out of five and or histological evidence.
These results provide a biochemical insight into the bone formation and bone resorption processes during allograft incorporation.
This is a retrospective study of 216 hips in 186 patients during January 1999 to December 2004. The study included review of notes and X rays and a questionnaire based assessment of hip function and activities using Oxford Hip Score (OHS) and Duke’s activity score (DAS). This study has got national ethical committee approval.
The response rate for questionnaire was 76%. Average age was 53.3 years (range 20–72). Male: female ratio was 3:1. There were 152 unilateral and 32 bilateral cases. Majority of the cases had osteoarthritis in the hip. Average follow-up was 30.3 months (range 12–72). Average length of stay was 6 days (range 3–17). Average OHS and DAS were 15.8 and 51 respectively. 163 patients had OHS of less than 24. 113 patients had DAS of 58.2.
Radiological assessment showed six cases of hetero-topic calcification. Lysis was noted at prosthesis-neck junction in two cases but patients were asymptomatic.
The complications included superficial wound infection in 2, DVT in 6, neuroparaxia of sciatic and brachial plexus in one case each. There were six dislocations. There were nine revisions – seven following fracture neck of femur and two for aseptic loosening. The incidence of fracture neck of the femur was high in early part of the study suggesting technical improvement with experience.
Overall failure was 4.1%, slightly higher than other published literature. The OHS and DAS were comparable to other published results.
In conclusion the results of the BHR are encouraging and long-term prospective study is needed to find out the longevity of the implants and long-term results.
2 cups had migrated and 6 had lucent lines. 8 femoral components had migrated. 6 had focal osteolysis. 66% of hips had ‘pedestal’ signs around the stem of the femoral component (classification proposed).
The extremely low failure rate in the medium term proves the suitability of resurfacing in young active patients. However, caution needs to be exercised until long term results are available.
There is sufficient evidence in this study to prove that metal ions do cross the placenta. There is therefore a continuing need for vigilance on the possible effects on the offspring born to patients with metal-metal devices.
Mean pre-operative HHS was 39.7 (±15.7) and the corresponding pain score was 13.4 (±8.49). The average post-operative scores were 89.5, 87.3, 88.4 and 85.8 at 1 year, 3 years, 5 years and final follow-up respectively. The corresponding pain scores were 42.7, 41.98, 42.1 and 41.94. Implant survival for the cohort as a whole was 95.5% at 12 years (ci: 88%–100%). Survivorship for the Weber Metasul cup was 93.4% at 12 years (ci: 82.7%–100%) and for armor cup was 100% at 11 years.
Complications included: dislocations (7), periprosthetic fractures (8), deep infection- early (3) & late (3), aseptic loosening (cup) (2) & heterotopic ossification (9). There were no untoward systemic complications with regards to metal ion release.
There has been controversy about the practice of mixing femoral and acetabular implants from different manufacturers in total hip replacement (THR). We studied the clinical outcomes of over 1500 patients in the Exeter Primary Outcomes Study (EPOS) who underwent primary THR with a cemented Exeter stem (Stryker) but with various acetabular components. This was a prospective non-randomised multicentre study. Patient reported hip scores (Oxford Hip Score (OHS)) were measured before operation and at 1 and 2 years post operatively. The choice of acetabular implant was at the surgeons’ discretion. 982 patients had reached four year follow up. Six types of acetabular component were examined (Exeter, Exeter Contemporary, Duraloc (all Stryker), Charnley (DePuy), Cenator (Corin), and Trilogy (Zimmer)).
Patients who received a Charnley cup were found to have worse pre-operative status (significantly higher OHS) than those receiving other cups (especially those receiving Exeter cups) (p< 0.01). Post operatively, this difference continued, with the absolute OHS value remaining greater (i.e. worse clinical result) for the Charnley cup at 1, 2, 3 and 4 years. The association of poor pre-op status with worse post-op result was anticipated. However, when the clinical benefit of surgery (i.e. the improvement in OHS between pre-op and post-op) was assessed, there was no significant difference between the various implants at 1, 2, 3 and 4 years.
These results demonstrate that initial clinical benefit of surgery does not differ between patients receiving acetabular implants from varying manufacturers when the Exeter stem is used. These patients will be followed further to determine whether such “mixing and matching” results in differences in longer term outcomes.
Complications were 1 fractured greater trochanter wired intra-operatively and 1 femoral nerve palsy which resolved in 3 months. There were no PE’s, dislocations or deep infections. No hip replacement has required revision.
We sought to establish whether HEMI or THA gave better results in independent mobile patients with displaced femoral neck fracture.
After THA, three patients died, three dislocated, one required revision. Mean walking distance was 2.23 miles and OHS was 18.8. There was no radiological evidence of polyethylene wear
Patients with THAs after three years walked further (p=0.039) and had a lower OHS (p=0.033).
THA is a preferable option to HEMI in independent mobile elderly patients with displaced intracapsular femoral neck fracture.
Of the 27 hips preserved, 14 had chondral ‘carpet’ flaps debrided, 17 underwent recession of the acetabular rim at the site of impingement, 6 had removal of medial osteophytes, 6 had labral and/or bony cysts excised and grafted and 1 underwent an osteochondral graft.
In 3 hips (12%) osteoarthritis progressed requiring hip resurfacing within the first year.
Oxford Hip Score improved from an average 36 (range 17–59) to 23 (12–45) and McCarthy hip score from 43 (9–74) to 62 (36–72) in the preserved hips at an average 15 months following surgery (range 6–33 months).
A series of sixteen patients, 14 males and 2 females with an average age of 50 years (28–93) underwent total hip replacement surgery after acetabular fracture. Thirteen patients had previously undergone internal fixation of their acute fractures. Hip replacement surgery was performed by a single surgeon over an eight year period at an average of 30.36 (range 3–84) months after injury. Cases include high energy injuries as well as low energy fractures of the elderly (2 patients).
These were complex procedures due in some cases to the dramatic femoral head and acetabular bone stock loss when avascular necrosis had occurred following internal fixation. The use of acetabular mesh, allograft and reinforcement rings is discussed.
At the time of reporting the total hip replacements in this group of relatively young patients continue to be highly successful. One hip has been revised for recurrent dislocation.
This paper describes important surgical tips for the management of these complex cases. Removal of exposed metal work can be difficult. A role for MRI scanning in the early postoperative care following fracture fixation is postulated. The importance of early liaison of fracture fixation surgeons with arthroplasty colleagues leads to earlier surgery with reduction of bone stock loss.
Neglected fractures of the acetabulum have been defined as those fractures that present to the surgical team after 3 weeks from the time of injury. Total hip arthroplasty in these cases often require a major acetabular reconstruction.
From 1989 until 2005, 38 total hip replacements were implanted in Cairo, Egypt for neglected acetabular fractures, with a follow up between 6 months and 192 months.
The male to female distribution was 33/5. The age distribution ranged from 22 to 70 years with a mean value of 47.7 years. In 30 cases, hip arthroplasty was carried out as a primary procedure due to associated acetabular cartilage damage beyond reconstruction and/or associated articular cartilage or structural damage to the femoral head. 8 cases were done after a previous attempt of open reduction and internal fixation due to failure of the reduction and fixation, avascular necrosis and/or infection.
34 acetabular components were treated by internal fixation of the columns if still mobile, autografts from the femoral head with cemented acetabular components. Four uncemented acetabular components were used in selected cases when a stable reconstructed acetabular rim was achieved. All femoral stems were cemented with the exception of five cementless stems.
At the last follow up, all grafted acetabular defects were taken with very satisfactory fixation in cemented cups. Three delayed acetabular loosening occurred at 13 years due to uncoupling of metal backed cemented acetabular components. Cementless acetabular components showed union of the fracture with stable acetabular fixation. The Merle D’Aubigne score was changed in all the cases from a range of 4/5 to 15/18.
We believe that neglected acetabular fractures can be satisfactorily treated by cemented total hip replacement using internal fixation of the columns and acetabular grafting.
Upper gastrointestinal (GI) bleeding in patients who undergo hip and knee arthroplasty tends to be associated with NSAID use, steroid intake, pre-existing peptic ulcers and smoking. The use of Aspirin for thromboprophylaxis is an added risk for the occurrence of GI Bleed. The aim of this study was to determine if the use of peri-operative oral Ranitidine reduces the incidence of GI bleeding when Aspirin thromboprophylaxis is used for hip and knee arthroplasty.
Data from 1491 consecutive patients who underwent Hip and knee replacements at the James cook university hospital (Group 1) and 886 patients who underwent Hip and Knee replacements at the Friarage hospital, Northallerton (Group 2) was analysed to determine the incidence of Gastro intestinal Bleeding. All patients received 150 mg of Aspirin per day for a period of six weeks from the day of surgery. Additionally patients operated at the Friarage Hospital received 300 mg of oral Ranitidine per day, for three postoperative days. Patients with clinically symptomatic GI bleeding were evaluated by the Upper GI team.
We observed that patients in Group 1 had a higher incidence of overt upper GI haemorrhage (n=14), which was statistically significant (p < 0.014) compared with patients in group 2(n=1). From the pooled data of both groups, there were 18 reported patients with symptomatic pulmonary embolism (0.75%) 3 of which were fatal (0.12%), phlebitis of deep leg veins in 31 patients (1.3%), deep vein thrombosis in 34 patients (1.43%), 5 of whom had embolic episodes, post operative infection in 22 patients (1.13%), and postoperative haemorrhage in 5 patients (0.2%). Thromboembolic phenomenon and pulmonary embolism was confirmed by autopsy in the three cases.
Based on this experience, we recommend the use of peri-operative gastric protection when aspirin is used for thromboprophylaxis in hip and knee arthroplasty.
6, 12, 18 and 24 months. Custom analysis software was used to improve precision. Zones were excluded if identified as affected by heterotopic ossification post surgery. For each group the mean and standard error was determined for each follow up. 137 had follow up data to 24 months.
A secure bone cement interface between the acetabulum and the cement mantle of the hip socket is an important requirement for the long-term success of a cemented hip arthroplasty. Cement pressurisation after bone bed cleaning enables cement to penetrate interstices of cancellous bone forming a superior fixation strength.
We designed an in-vitro experiment to evaluate the performance of the Exeter, Depuy T-handle and a plunger-type pressurisers using two parameters: cement penetration and cement pressurisation.
The deformation of the flexible pressure head of the DePuy model produced a cement mantle, which is thick at the pole but tapered at its rim and variable in the amount of penetration produced (range 2–8mm) for an estimated similar force. Pressures of up to 60KPa were generated throughout the model acetabulum. The Exeter pressuriser was found to produce cement mantles more compatible with a socket. However, the test results show a wide variation in cement penetration occurring for what was estimated to be a similar applied force (3mm to 9mm at the pole and 5mm to 9mm at the rim). It was also shown to have the disadvantage of causing widely dissimilar pressures at the pole and the rim. The plunger protrusion required to produce 5mm cement penetration was found to be 7.5mm. Since this protrusion can be monitored and controlled by the operator, a cement intrusion of 5mm +/−1mm was found to be reproducible with the plunger-type device. The maximum variation in intrusion between rim and pole was 1 mm. Maximin pressures of 70KPa were generated.
We have presented experimental evidence that suggests that a plunger type of acetabular cement pressuriser may provide a more consistently reproducible level of pressurisation leading to optimal cement penetration.
There have been no major surgical complications. In particular, there have been no failures of acetabular fixation, dislocations or deep infections.
The Barrack scoring system was used as a tool to evaluating cementation quality in all cases.
The mean preoperative Hb of patients who required blood transfusion was 11; S.D. 1.49 while those who did not require a transfusion it was 12.5; S.D.1.42. Transfusion was required in 23% of patients having extra-capsular neck of femur fractures fixed with a DHS and in 9.5% of patients having intracapsular neck of femur fractures undergoing a hemiarthroplasty.
The univariate analysis showed a significant relationship between post-operative transfusion and the pre-operative Hb level (p=0.0001) and the type of fracture (p=0.001). However no relationship was found between transfusion and age (p=0.423) and the gender of the patient (p=0.611).
There has been renewed interest in metal-on-metal bearings as hip resurfacing components for treatment in young, active patients. This study examines the effects of fixation (cemented or uncemented heads) and bone-implant interface conditions (stem-bone and head-bone) on the biomechanics of the Birmingham hip resurfacing (BHR) arthroplasty, using high resolution, 3-d computational models of the bilateral pelvis from a 45-year-old donor. Femoral bone stress and strain in the natural and BHR hips were compared. Bone remodelling stimuli were also determined for the BHR hips using changes in strain energy. Proximal femoral bone stress and strain were non-physiological when the BHR femoral component was fixed to bone. The reduction of strain energy within the femoral head was of sufficient magnitude to invoke early bone resorption. Less reduction of stress was demonstrated when the BHR femoral component was completely debonded from bone. Bone apposition around the distal stem was predicted based on the stress and strain transfer through the stem. Femoral stress or strain patterns were not affected by the type of fixation medium used (cemented vs. Uncemented). Analysis of proximal stress and strain shielding in the BHR arthroplasty provides a plausible mechanism for overall structural weakening due to loss of bony support. It is postulated that the proximal bone resorption and distal bone formation may progress to neck thinning as increasing stress and strain transfer occurs through the stem. This may be further exacerbated by additional proximal bone loss through avascular necrosis. Medium term retrieval specimens have shown bone remodelling that is consistent with our results. It is unclear if the clinical consequences of neck thinning will become more evident in longer-term follow-ups of the BHR.
This project assessed the long-term stability of this design at different orientations, by measuring the change in surface strain distribution following its insertion.
One potential limitation with uncemented, hemispherical metal-backed acetabular components is stress shielding of bony structures due to the mismatch in elastic modulus between the metal backing and the peri-prosthetic bone. A proposed substitute is a horseshoe-shaped acetabular component, which replicates the bony anatomy. One such device, the Cambridge cup, has shown successful clinical and radiological outcomes at five years follow-up (Brooks 2004, Field 2005). We conducted a study of the Cambridge cup from a biomechanical perspective, using validated, high-resolution computational models of the bilateral hip. Peri-prosthetic stress and strain fields associated with the Cambridge cup were compared to those for the natural hip and a reconstructed hip with a conventional metal-backed hemispherical cup during peak gait loading. We found that the hemispherical cup caused an unphysiologic distribution of bone stresses in the superior roof and unphysiologic strain transfer around the acetabular fossa. These stress distributions are consistent with bone remodelling. In contrast, the peri-acetabular stresses and strains produced by the Cambridge cup differed from the natural hip but were more physiologic than the conventional hemispherical design. With the Cambridge cup, stresses in the superior acetabular roof, directly underneath the central bearing region, were greater than with the conventional design. Despite the thin bearing, the peak liner stresses in the Cambridge cup (max. tensile stress: 1.2 MPa; yield stress: 4.5 MPa) were much lower than the reported material strengths. Fossa loading by the hemispherical cup has been suggested as a possible mechanism for decreased implant stability (Widmer 2002). Conversely, the Cambridge cup produced semi-lunar peri-prosthetic stress fields, consistent with contact regions measured in natural hips (Widmer 2002). These analyses provide a better understanding of the biomechanics of the reconstructed acetabulum and suggest that a change in component geometry may promote long-term fixation in the pelvis.
Dislocation rates in large headed metal-on-metal resurfacings are extremely low. However, many patients are unsuitable for resurfacing and need a replacement. In such cases, it is attractive to transfer the large-headed metal-metal bearing advantage to replacement arthroplasty in order to reduce wear and dislocation rates. Does large diameter metal-metal total hip replacement really reduce the early dislocation rate?
Age at operation ranged from 37 to 83 years. Thirty patients were 55 years or under, eighty one were 56 – 65 years and ninety five were over 65 years. There were 122 females and 67 males. Posterior approach was used in all.
There is concern that patients undergoing total hip replacement by trainee surgeons may do worse than those operated on by consultants. We examined the clinical outcomes of over patients in the Exeter Primary Outcomes Study who underwent primary THR with a cemented Exeter stem (Stryker) with various acetabular components. Over 1400 patients entered the prospective non-randomised multi centre study. Patient reported hip scores (Oxford Hip Score (OHS)) were measured pre operation and at 3 months, 1,2,3 and 4 years post operatively.
The number of patients assessed at 4 years was 982. Trainees operated on patients with worse pre-operative OHS (p< 0.05; t test)) and on significantly less patients under 60 years (p< 0.05 chi square). There was no significant difference in the improvement in OHS (i.e. pre-op OHS – post-op OHS) at any post-operative time point between consultants and trainees. However, patients operated upon by consultants had consistently better postoperative absolute OHS scores (p< 0.05 at 3 months and 1, 2, 3 and 4 years; t test). Complications were low in both groups. Operations performed by trainees lasted longer (mean of 104 vs. 85 minutes). There was also no difference in OHS scores of patients operated by trainees whether they were assisted by an SHO (n=132) or by a consultant (n=249).
In this large cohort of patients there was no difference in the improvement in OHS between patients operated by registrars and consultants. The difference in the absolute OHS values is likely explained by the difference in pre-operative status. We conclude that THRs performed by consultants and by trainees under appropriate supervision give similar initial clinical results. Given current changes to shorten surgical training, it is important that outcomes of THRs performed by future trainees are reviewed to ensure that outcomes are maintained.
HO was found to be significantly associated with male gender and increasing age at time of operation. Surgical approach to the hip also had an effect, osteotomies producing a greater incidence of HO formation.
Cementless total hip replacements (THR) have a theoretical advantage over cemented designs in that bone lysis and probably aseptic loosening are less common complications. NICE guidelines suggest that prosthesis should have an aseptic loosening rate of < 10% at 10 years. Long-term follow-up of the Joint Replacement Instrumentation (JRI) Hydroxyapatite coated (HAC) Furlong system is gradually emerging following its first clinical application in 1985.
A retrospective study was performed to identify all patients having undergone a primary JRI HAC THR under a single Consultant at Barnsley Foundation Hospital NHS Trust between 1985 and 1995. This identified 124 joints in 106 patients (52% males). All living patients were sent a modified Oxford Hip Score questionnaire; case notes were also reviewed to identify any revision surgeries.
Median age at operation was 54.0 years. 17 patients (16%) had died at the time of this study. Median follow-up was 13.7 years (range 9.4–18.5 years). For 30 patients (24.2%) it was impossible to gather data on the survival of the hip.
Mean survival of all hips followed up was 16.2 years. Twenty-four hips (19.4%) required revision surgery; the median time to this surgery was 10.2 years, mean 8.2 years. Reasons included aseptic loosening of the stem in one patient at 12.7 years, aseptic loosening of the cup in 7 patients (range 10.2–17.4 years), worn polythene insert in 4 patients, infective loosening in 3 patients and recurrent dislocations in 2 patients. The remainder of revisions were for unknown reasons.
The Oxford Hip Score postal questionnaire was returned by 79% of patients. Mean score was 12.6/45 but 88% of patients reported overall satisfaction with the hip.
In summary, there were no revision surgeries at ten-year follow-up for aseptic loosening.
We have analysed the wide variation in the management of these cases. The majority of authors in our review resected or revised the infected prosthesis. We are of the opinion that if the infection is clinically under control and the prosthesis is stable, medical treatment alone should suffice.
Supero-medial migration was seen in 27 (49%) of cases, demarcation without migration was seen in 18 cases (33%) and supero-lateral migration was seen in 7 (13%) cases. There were 2 (4%) socket fatigue fractures due to wear. There was 1 (2%) patient with a worn socket and no loosening.
Reconstruction was achieved by impaction bone grafting alone in 25 cases, IBG and a block allograft in 9 cases, cement alone in 8 cases and IBG with a rim mesh in 4 cases.
In cases where the supero-lateral margin of the socket was covered by host bone, failure always occurred by demarcation alone or in association with supero-medial migration. Rim defects significant enough to require reconstruction were seen in only 4 of these 45 patients (9%). Failure by supero-lateral migration was only seen in the cases of DDH where the socket was left uncovered or where the socket had fractured.
The pattern of socket failure can be reliably predicted from the original post-operative x-rays. Care should be taken to ensure adequate supero-lateral coverage in order that demarcation and migration leave an intact rim for reconstruction.
We aim to set up a nurse practitioner clinic to bridge the gap. Secondary aim is to reduce patients’ complaint about the services.
For first time dislocations with a stable EUA 8% always used an abduction brace and 50% never used one. 20% were managed with a period of bed rest. For an unstable EUA, 40% always used a brace and 23% never used one. 31% were managed with a period of bed rest. When a brace was used, the majority (75%) used it for 6 weeks (range 2 to 12 weeks).
For recurrent dislocations, with a stable EUA, 65% used a brace for at least 6 weeks. For an unstable EUA 74% used a brace for at least 6 weeks and 15% managed with a brace permanently or until revision.
50% asked the patient to wear the brace 24 hours a day including whilst asleep, the only exception being for washing. The others were varying from 12 to 16 hours a day.
The commonest criteria for revision surgery were recurrent dislocation (seen as more than three), component malposition, aseptic loosening and instability at EUA. The questionnaire was answered by orthopaedic surgeons who all had experience in revision surgery, the majority having performed over 100 revision THR in the past 5 years.
Cement leakage –cement was seen to have escaped past the cement restrictor Restrictor dislocation – the restrictor was 4 or more centimetres distal to the stem tip Restrictor penetration –the tip of the femoral stem was resting on the restrictor All cement mantles were given a barrack grading.
Old age, osteopaenia, alcohol abuse, and large cysts are risk factors for fractures. It has been suggested that performing a bilateral resurfacing puts the first side at risk of fracture from the force used in implanting the second resurfacing. Is this a true risk or a sampling error?
The low incidence of fractures (2/382, 0.5%) in this bilateral resurfacing series does not support the view that there is an increased risk of fracture from a bilateral procedure.
There has been controversy about whether limb length discrepancy (LLD) affects outcome after total hip replacement (THR). We examined input variables and outcomes of over 1200 patients who received primary THR with the Exeter stem and a variety of acetabular components in the Exeter Primary Outcomes Study. This was a non randomized prospective multi centre study.
We examined whether specific groups of patients or surgeons were more likely to have LLD at one year after surgery. Data for leg length measured on clinical assessment were available for 1207 patients at 1 year. 237 patients were recorded as having a leg length difference of 1 cm or more, and 73 a difference of 2 cm or more. 138 were longer on the operated side and 99 were shorter. The likelihood of having LLD of 2 cm or more was not significantly affected by the grade of surgeon (consultant or trainee), BMI, age of patient, position of patient during surgery or surgical approach, or the use of regional or general anaesthetic.
We examined the effect of LLD on outcomes at 3 months and 1,2,3 and 4 years. Patients with LLD > 1cm had significantly worse Oxford Hip Scores (OHS) at 1, 2, 3 and 4 years (p< 0.01), with the OHS generally being an average 2 points worse in those with LLD. The most consistent difference between those with and without LLD was a patient reported limp on the Oxford Hip Questionnaire.
We conclude that LLD is a common problem after THR and that all patient groups may be affected. It is associated with a significantly worse functional outcome as measured by a validated hip score. Systematic adoption of accurate intra-operative measures of leg length might pay dividends in minimizing this complication.
We describe the early results of twenty trabecular metal backed acetabular components in the revision setting.
Fixation was augmented in all cups with at least one screw.
Patients were evaluated with standard x-rays for osteolysis and migration, Harris hip score, SF 36 and Oxford hip score.
There were no revisions. There are no progressive radiolucencies or detectable migration in any of the cups. There were no dislocations.
The treatment of undisplaced femoral neck fracture in the elderly population is still controversial. We analyzed the outcome of cancellous screw fixation for undisplaced femoral neck fracture in patients over 70 years.
26 (32.9%) patients did not return to their pre-morbid mobility status, 5 (6.3%) of which did not return to their preadmission dwelling (2 went to residential home and 3 went to nursing home).
We had documented radiographic details in 46 patients: 41 patients had a healed fracture on radiographs (89.1%), 4 patients had AVN, 4 patients had non-union and 1 patient had AVN with non-union. The failure rate was 19.6%. 15 patients had evidence of screw back out with healed fracture.
12 out of the 46 complained of pain postoperatively of which 9 (19.6%) patients had re-operation: 6 (13%) underwent revision surgery and 3 (6.5%) required screw removal.
30-day mortality was 3.7%. 1-year mortality was 23.2% of which 16 died within the first 6 months (19.5%).
Total hip replacement is a successful and reliable procedure for the relief of pain, but the results achieved have been reported to be less successful in younger patients who tend to be relatively more active and place greater demands on prostheses than older patients.
Between 1966 and 1978, 226 Charnley low friction arthroplasties (LFAs) were implanted in young patients with an average age at operation of 31.7 years. Initial results were presented at an average of 19.7 years. We have performed a further retrospective analysis of this cohort at 10 years on from the time of data collection of the original study. Of the original cohort, 112 patients are alive and either under follow-up at our hospital or have been traced to other hospitals. 16 have been lost to follow-up. Mean follow-up was 26.4 years. At the time of final follow-up or death, rate of aseptic loosening of the stem was approximately 80%. Acetabular components proved to be less successful with less than 60% remaining well fixed. Differences in survival were apparent between subgroups with differing original pathology with stem survival greater in those with DDH as opposed to rheumatoid or degenerative arthritis and the opposite being true for socket survival.
This study adds to the available knowledge of the longevity of cemented total hip replacement as performed with unsophisticated cementation techniques and how it may perform in differing patients groups.
We conclude that if possible, a standard C-stem should be inserted but if a CDH stem is used attention to patients’ weight is paramount.
The optimal surgical approach for total hip replacement (THR) remains controversial. We report the clinical outcomes of over 1000 patients in the Exeter primary outcomes study (epos) who underwent primary THR with a cemented Exeter stem (Stryker) but with various acetabular components. This was a prospective non randomised multi centre study. Patient reported hip scores (oxford hip score (OHS)) were measured before operation and at 3 months (n= 1312), 1 (n=1276), 2 (n= 1225), 3 (n=1205) and 4 (n=975) years post operatively. Physician reported scores (Merle d’Aubigne / Postel, MDAP) were measured before operation and at 12 months. All of the operations were carried out using either the anterolateral (Hardinge or modification) or posterior approach.
The posterior approach gave better absolute OHS scores at 3 months and 1 year compared with the anterolateral approach. The improvement in OHS between the pre-op and relevant post-op score was better for the posterior than the Hardinge approach, and this extended to 4 years (all p< 0.05). Early dislocation rates were low in both groups. There was significantly more likely to be heterotopic ossification in the Hardinge group, while stem alignment into varus was more common in the posterior approach group. There was no significant difference between the two approaches as measured using the MDAP score at pre-op or at 12 months after surgery.
These results demonstrate that initial patient perceived clinical benefit of surgery is greater using a posterior than with an anterolateral approach. This should be considered when assessing the best approach for a particular patient. The current results emphasise the value of using patient based outcome measures, as the MDAP score did not detect a difference in outcomes between the two groups.
Introduction: The curing of polymethylmethacrylate cement is an exothermic reaction, with temperatures reaching 80oC. Thus contact with cement can result in thermal injury. During orthopaedic procedures bone cement may be inadvertently left lying on surgical drapes. This study aims to investigate the effect of drapes on the contact temperature of such cement.
Operation data is now entered onto the database by the surgeon or co-ordinator at the time of surgery. Thereafter, the database automatically produces annual Oxford Hip Questionnaires, EQ-5D questionnaires and invite letters to patients for clinical review at stipulated time-points.
Questionnaires are returned by patients and scanned. This data is then electronically imported to the database without transcription error. Patients attend special Outcome clinics, staffed by Research Fellows and SpR’s, who examine the relevant hip and review their radiographs. The findings are recorded and the paper forms scanned and imported into the database. Non-responders are identified from the database and are chased up via telephone by the coordinator.
Data is extracted from the database with queries and presented using database reports.
An earlier study (Clarke et al JBJS(Br) 2003) suggests that smaller bearings generate less wear. In that study bearings with different metallurgy and wear properties were grouped together, a potential confounding factor. The present study does not suffer from that error and our findings do not support the view that a larger bearing diameter leads to either an increase or decrease in metal ion generation.
Mean scores of PF, RP, RE, SF, EV and Pain improved significantly following THR. The improvement remained significant throughout the follow-up (p< 0.0005). MH was the only dimension which did not change significantly after THR. There was a significant decline in GHP (p< 0.0005).
Females reported lower scores in all dimensions apart from GHP. They were also significantly older than the males (66.66±9.41 vs. 64.69±10.27 years; p< 0.037).
Patients who had unilateral or bilateral THR reported similar scores preoperatively and in the initial follow-up. Significant differences were only noted at 3 and 5 years with the bilateral group reported a higher score.
The average length of stay was 1.2 days. The mean pain score on discharge was 1.3/10. The Oxford Hip Questionnaire and Merle d’Aubigne scores were comparable to patients who underwent surgery prior to the introduction of the new protocol. Minimising in-patient stay for total hip replacement benefits the patient by reducing exposure to nosocomial infection and expediting the return to a normal environment for faster rehabilitation. This new program allows patients undergoing total hip replacement to be discharged after 1 night post operatively without compromising safety or quality of care.
Bland-Altman analysis (Figure 1A) shows the limits of agreement between serum and WB are unacceptably wide (1.7 to -5.1 for chromium) suggesting poor agreement.
As a result of the increased popularity of metal-on-metal bearings for total hip arthroplasty, concerns have been expressed about patient exposure to increased serum metal ion levels.
We therefore performed a retrospective review of patients with metal-on-metal, uncemented Ring total hip replacements with a minimum follow up of thirty years.
After allowing for prosthesis revision and patient mortality, 6 hips in 5 patients were reviewed and serum ion levels measured. Similar cohorts of patients with other combinations of bearings were compared with an age-matched osteoarthritic control group.
Serum cobalt and chromium levels in the metal-on-metal hip arthroplasty group were significantly higher than in all other groups and approximately five and three times greater respectively than in the group with no implants. Unlike the stainless steel-on-plastic group, the cobalt/chrome-on-plastic group showed significantly raised serum cobalt levels compared with the control group. It is of interest that patients who have had their metal-on-metal hip replacements revised to metal-on-plastic, have metal ion levels that are not statistically different to those of the osteoarthritic control group.
Though we acknowledge the small numbers of patients studied, no identifiable harmful effects were found.
We conclude that serum metal ions remain elevated throughout the life of the metal-on-metal articulation. Metal bearing hip arthroplasty is being used in ever younger patients and together with increased life expectancy we are exposing our patients to potentially harmful levels of metal ions throughout the life of the implant.
The purpose of this study was to determine whether there is a significant difference in femoral component alignment when the posterior and direct lateral approaches are compared.
AP radiograph Tip of stem to outer medial cortex. Tip of stem to outer lateral cortex. Lateral radiograph C Tip of stem to anterior outer cortex D Tip of stem to posterior outer cortex.
Component alignment was defined as A – B and C – D.
Most friction studies are conducted in a bovine serum- carboxymethylcellulose (bs-cmc) medium. Following implantation however, the joint is bathed in blood which contains macromolecules and cells. The effect of these on friction is not fully understood.
A progressive radiolucent line (fig 1) observed in some low clearance resurfacings raises the concern that increased friction may be affecting component fixation. The purpose of this investigation was to study the effect of clearance on friction for a given bearing diameter in the presence of blood as lubricant.
The results of this study suggest that reduced clearance bearings have the potential to generate higher friction when blood is the lubricant. this higher friction in the low clearance bearings may produce micromotion in the early postoperative period and hamper bony ingrowth resulting in impaired fixation with long-term implications for survival.
Complications included dislocation (13 out of 53 patients or 24.5%), heterotopic ossification (47%), screw fracture (8%), superficial infection (11%) and deep infection (5.7%). Survival tables show an implant survival rate of 85% at 5 years.
Complications were 1 calcar fracture and 1 greater trochanter fracture (both of which required circlage wires). There was also 1 temporary femoral nerve palsy which resolved in 3 months. There were no fatal PE’s, deep infections or dislocations. No hips have required revision.
With regard to functional activity, 21% of patients in both the groups scored 8 or more on the UCLA activity scale. 21% of patients in the BHR and 14% in the Furlong group scored 3 or more on the Tegner activity scale
Pre operative diagnosis was Osteoarthritis (n=135), osteonecrosis(n=8),traumatic(n=2),dysplasia(n=3),Slipped capital femoral epiphysis (n=1) and ankylosing spondylitis (n=1). Al hips were implanted via the posterior approach. Clinical assessment, by postal questionnaire, was by pre and post-operative Oxford Hip scores (OHS) and X-rays were reviewed.
There was one dislocation in a neuropathic hip requiring bracing. (OHS 29). There was one retained alignment pin needing removal. Otherwise patients were highly satisfied with the operation with excellent function and Hip scores.
Initial blood tests revealed very high ESR, c-reactive proteins with leucocytosis. Blood cultures were negative. X-rays revealed dislocation of Total hip replacement Ultrasound scan and CT scan revealed a large collection of fluid in the Left Total Hip Replacement.
Aspirate from the affected joints revealed gram negative bacilli, Streptobacillus moniliformis. The joints were all washed out arthroscopically. She was put on intravenous antibiotics and continued for six weeks. The inflammatory markers normalised after six weeks. Follow up x-rays of the left hip prosthesis do reveal some signs of osteolysis and surveillance is ongoing.
Weight gain is often reported by patients who succumb to impaired activity as a result of progressive osteoarthritis of the hip or knee. Optimistic views of weight loss after joint replacement are often held by patients. We studied the affect of lower limb arthroplasty on body weight.
We reviewed 144 patients having undergone hip and knee arthroplasty and were functionally well. Infected cases were excluded. Average age was 65 years and average follow up was 27 months. The Body Mass Index (BMI) was prospectively measured at follow up and compared to immediate pre-operative BMI.
Our findings demonstrated an average rise in BMI post-operatively which was statistically significant. A rise in post operative BMI was seen in patients who were obese to start with or those who had undergone a total hip replacement (statistically significant). Moderate rises were seen in patients who had underwent hip resurfacing procedures or those who were overweight preoperatively (p=0.06).
These findings are useful in informing patients of achievable expectations following joint replacement surgery and preoperative overweightness should be treated as a separate entity unrelated to co-existing joint degeneration.
When measured along Blumensaats line from the anterior condylar surface, the femoral tunnel in the saggital plane should be found at 75% of the total anteroposterior distance, the recorded figure in this audit was 74%. Measured from the anterior edge in the saggital plane, the tibial tunnel should be found at 44% of the total tibial depth, our measurements averaged 40%. The tibial tunnel in the coronal plane should be found at 45% of the total width from the medial edge, our measurements averaged 46%.
57 (53%) of the radiographs demonstrated imperfect lateral projection of greater than 2mm.
This is a prospective study of 74 consecutive LCS total knee replacements of which 34 were meniscal-bearing and 40 rotating-platform total knee arthroplasties comparing functional and radiological outcome measures of the New Jersey total knee replacement.
The study is based on a cohort of 96 patients who were followed up over a period of 8.6 to 15.6 years (mean 11.8 years). 49 patients (64 knees) were living and 5 patients were lost to follow-up. At time of follow-up 37 patients were dead. The patients were aged 23 to 81 (mean 64.5) at the time of surgery.
The methods used include a pre- and post-operative New Jersey Orthopaedic Hospital Scoring Scale (NJOHSS). In addition the cohort were assessed postoperatively using the Knee Society Score (KSS) and the Knee Society Radiological Evaluation Form (KSREF).
The results of the study showed that there was a significant overall improvement in the NJOHSS (mean improvement = 22.4 points) with 81% of the cohort scoring ‘good to excellent’ post-operatively. When the two types of arthroplasty were compared there was no significant difference in improvement in the NJOHSS. However, both the ‘Post-op’ and ‘Function’ components of the post-operative KSS were greater in the rotating-platform total knee replacement. The comparison of the post-operative KSREF did not show any significant differences between the two types of arthroplasty.
Revision procedures were carried out in 3 patients with meniscal-bearing arthroplasty and 2 patients with rotating-platform arthroplasty. Of the Meniscal-bearing group two were for sepsis and one required liner exchange. Both of rotating-platform group were revised for aseptic loosening.
We therefore conclude that there was excellent long-term survival of the LCS knee arthroplasty in this cohort and there was no significant difference in functional outcomes for either knee replacement. We also note that there have been no revisions for aseptic loosening in the meniscal-bearing group to date.
We have conducted a case controlled study on a novel cementing technique and compared the results with published optimum levels.
In order to achieve optimum cement penetration we recommend that attention is paid to good pressurization and cement penetration and describe our technique for doing this.
All patients were assessed preoperatively with knee examined in one of seen different methods. EUA followed by arthroscopy. Clinical and arthroscopic findings were correlated and sensitivity and specificity were determined.
The study is ongoing with following results.
Those randomly assigned to the Tranexamic Acid group received 500mg intravenously five minutes prior to tourniquet deflation and a repeat dose three hours later. Those assigned to the Topical Fibrin Spray group received 10mls of the combined product intra-operatively. Those in the control group received no pharmacological intervention.
We report the results of a prospective randomised controlled clinical trial assessing the radiosterophotogrametric analysis (RSA), clinical and radiological performance of a metal backed and an all-polyethylene tibial cruciate retaining, condylar design, PFC-TKA up to twenty four months.
65 patients were recruited, of which 41 patients were randomised. There were 20 metal backed and 21 all-polyethylene. None were lost to follow-up. There were no significant inter-group demographic differences. We found a significant increase in SF-12 and Oxford knee scores after surgery in both groups. No significant difference was found between the groups in the RSA, SF-12, Oxford Knee score, radiological alignment and range of movement at 6, 12 or 24 months. At 2 years one metal backed implant showed translational migration > 1mm. No all polyethylene implant migrated > 1mm. Further analysis identified possible progressive subsidence of the metal backed implants compared to all-polyethylene implants, although the magnitude of this difference was very small.
We conclude that in the uncomplicated primary total knee arthroplasty, all polyethylene PFC-_ tibial prostheses had equivalent performance to the metal backed counterpart, using RSA as the primary assessment instrument at 24 months. We found no differences between the two designs as assessed by the secondary instruments: SF-12, Oxford knee score, alignment and range of movement at 24 months. Should half of all primary total knee replacements performed in the UK receive an all-polyethylene tibial implant, the estimated annual cost saving would be 21 million pounds per annum.
We report the results of 60 consecutive primary anterior cruciate ligament (ACL) reconstructions performed by a single operator at King’s College Hospital Day surgery unit. A “3 in 1” nerve block was used after general anaesthesia. Semitendinosis and gracilis were harvested from the ipsilateral side, doubled and implanted arthroscopically. Patients were discharged the same day with oral analgesia. The mean age was 34.7 years old (range 18–58). Mean period between injury and reconstruction was 26.9 months (range 6–63 months). Mean follow-up was 38 months (range 7–86 months). Average post operative pain score was 3.86 with an average analgesic requirement of 11.2 days (range 0–50 days) Mean Modified Lysholm score was 85.63 (range 31–100) and mean IKDC score was 79.83 (range 37–100).
In conclusion we found that following day surgery ACL reconstruction, pain relief was adequate in most cases, functional outcome was rated good or excellent by 78% of patients and 91% were satisfied with the overall service.
ACL Reconstruction was done by a standard 4-strand hamstring technique using an endobutton proximally and a spiked washer and screw distally in the tibia.
The IKDC, Lysholm and Tegner scores were used to assess the knees pre and post-operatively. Stability was measured using the KT-1000 arthrometer.
Of the 11 patients who had an arthroscopy, 4 were told that they had an ACL injury. None of the 15 who had an MRI scan were told that they had an ACL injury.
A review of the outcome, safety, practicality and cost effectiveness of day surgery anterior cruciate ligament (ACL) reconstruction was studied in the British set-up.
From January 2003 to May 2005, 75 patients who underwent day case arthroscopic ACL reconstruction without the use of tourniquet or nerve blocks, but using a pump-regulated saline-epinephrine irrigation system were studied prospectively. 68 patients had a hamstring tendon graft and 7 patients had patellar tendon graft reconstruction. None of the patients required overnight stay. Mean immediate postoperative Visual Analogue Score (VAS) for pain was 2.5 (range1–8) and 0.5 (range 0–3) at 6 weeks indicating excellent pain control. The mean follow-up was 14 months (range 6–30 months). We had no early or late complications in this series. ACL specific Mohtadi Quality of Life Index improved from pre-operative score of 20 (15–40) to 93 (80–100) at 9 months after surgery. The mean Modified Lysholm Knee Score was 93.9 points, (range 80–100) at the 9 months follow-up examination. On Tegner activity score, 68 patients returned to the same level of sporting activity at 8 months and the rest 7 patients dropped 1 level. The average saving per patient was in the range of 50–60% when compared to inpatient ACL reconstruction.
In conclusion, day case ACL reconstruction using a pump-regulated saline-epinephrine irrigation system is safe, cost-effective and is the patient’s choice.
We found no significant difference between the groups in the EMG intensity of vastus lateralis relative to biceps femoris, or vastus medialis relative to vastus lateralis, during the balance test or during the step up task (Mann Whitney U test all p> 0.05). We did not find any difference in the proprioceptive abilities of the two groups
Cadaveric experiments using knee testing machines have suggested that anatomical ACL reconstruction, replacing both antero-medial (AM) and postero-lateral (PL) bundles, restores knee rotation kinematics more effectively than does a single-bundle. The aim of this study was to measure intra-operatively the control of the translation and coupled rotations that occur with standard clinical laxity tests (anterior drawer, Lachman and pivot shift).
The knee kinematics of 10 patients were measured using a surgical navigation system and described in terms of tibial axial rotation and antero-posterior translation. In the ACL deficient knee, the average maximum tibial rotation during the pivot shift test was 29.0° and the mean maximum translation 17.0 mm. Reconstruction of the AM bundle (which behaves in a biomechanically similar way to a single-bundle reconstruction) reduced the rotational component to 16.4° (p< 0.0001) and translation to 6 mm (p = 0.0002). Addition of the PL bundle further reduced rotation to 12.6° (p = 0.0007) but had no significant effect on translation. Addition of the PL bundle also significantly reduced coupled tibial internal rotation during the Lachman and Anterior draw tests.
The pivot shift test simulates the instability suffered by patients with ACL deficiency and this study suggests that its rotational component is better restrained by anatomical, 2 bundle ACL reconstruction.
To describe the degree and type of disability experience by patients with combined postero-lateral corner and posterior cruciate ligament knee injuries To document any dynamic abnormalities of the lower limbs through the gait cycle using kinematic and kinetic gait analysis To identify abnormal electromyographic signals of the quadriceps, hamstring and gastrocnemius muscles through normal gait.
Significant functional disability was noted in all patients. Characteristic gait abnormalities identified included hyperextension and dynamic varus deformity with a corresponding increase in the internal valgus knee moment. Electromyographic data revealed early and prolonged contraction of the medial hamstrings and gastrocnemius muscles.
The aim of this study was to evaluate the functional and clinical outcome following medial patello-femoral ligament reconstruction using autogenous hamstring tendon grafts for patellar instability.
Over a 4 year period the senior author operated on 35 patients for lateral instability of the patella. The predominant initiating event was a sporting injury. Patients were evaluated clinically and functionally. The Fulkerson score was utilised pre and post operatively. The minimum follow up was 6 months, the mean follow up was 20 months. There were 18 males and 17 females. The mean age was 24.6 years. The mean pre-operative Fulkerson score was 59.3(range 6–100). The mean post operative Fulkerson score was 83.6(range 25–100), the mean improvement was 24.3.
24 patients returned to sporting activities
The main complications was one patient with a patella fracture that was stabilised with internal fixation, one patient requiring exploration and reinforcing the ligament which had attenuated. Both patients finally had a good clinical outcome.
Our study has shown that symptomatic lateral instability of the patella can be effectively treated with a medial patello-femoral ligament reconstruction and result in overall good clinical and functional outcome.
We would recommend this technique
The patients evaluated at 10 days, 3 weeks, 6 weeks, 3 months and every 3 months afterward up to 1 year. Average follow up was 9,3 months (range 3–12mounths).
Subjective data were calculated using the IKDC system, objective data included a comprehensive knee examination and evaluation and comparing it with normal side, which was used as a reference.
There has been no recurrence of the instability or tenderness around the knee, nil infection rate, normal side-to-side movement of the patella comparing with normal side, full range of motion, and normal quadriceps belly and strength.
The patient returned to light sports activities at 6 weeks, and to their pre injury level of sport at 3 months.
Periprosthetic fractures around Total Knee Arthroplasty are potentially devastating complication to both the patients and the surgeons. The reported prevalence of supracondylar femoral fractures following Total Knee Replacement has ranged from 0.3 to 2.5 percent. The complication rates of various treatment modalities reported in literature varies from 25 to 70 percent.
The modified Cincinnati scores (MCRS) of eighty-six patients were evaluated prospectively at one year and at the latest follow-up following ACI-C (mean follow-up= 4.7 years. Range= 4 to 7 years). All these patients underwent biopsies of their cartilage repair site performed at variable periods between six months and five years following ACI-C (mean=22.2 months). The neo-cartilage was graded as hyaline (n=32), mixed fibrohyaline (n=19), fibrocartilagenous (n=35) and fibrous (n=0).
However, their clinical scores at the latest follow-up demonstrated a significantly superior result for those with hyaline repair tissue when compared to those with mixed fibro-hyaline and fibro-cartilagenous repair tissue (p=0.05). The percentage of patients with excellent and good results for those with hyaline, mixed fibro-hyaline and fibro-cartilagenous repair was 75, 42 and 68.6 respectively. Their mean MCRS were 70.6, 56.8 and 63.9 respectively.
Visual Analogue Score and Bentley Functional rating score showed significant improvements compared to pre-operative levels (p< 0.0001) with ongoing yearly sequential improvement.
Patient Rating and Brittberg scores, both subjective patient scores, similarly showed continuing improvements in the years following surgery.
The fractures were loaded using a Lloyd’s machine and a load displacement curve was plotted.
Non-osteoporotic model. The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct (p=0.42).
An increased fragmentation of the synthetic bone fragments was noticed with the 2-screw construct but not with the 4-screw construct.
No significant differences were found between the 2 groups in the measured parameters.
The aim of this prospective cohort study is to compare the early results in a single surgeon series of the mobile and fixed bearing versions of the Preservation UKR for lateral OA. Lateral UKRs were only considered for patients with isolated lateral compartment osteoarthritis with a functioning anterior cruciate ligament. Mild patellofemoral osteoarthritis was not considered a contraindication. If there was any doubt over the condition of the medial compartment or patellofemoral joint, single photon emission computed tomography was performed. Significant uptake it the medial or patellofemoral joint was considered a contraindication. Patients were assessed preoperatively and at 1 and 2 years postoperatively with the American Knee Society Score (AKSS), Oxford Knee Score (OKS) and with anteroposterior, lateral and Rosenberg radiographs.
Between 29th May 2001 and 15th May 2003, the senior author (GK) performed 233 consecutive Preservation UKRs. Of these, 30 were lateral UKRs (13%) performed in 12 men and 16 women (2 bilateral cases) with a mean age of 67 years (range 36 to 93 years). A metal-backed mobile bearing tibial component was used in 13 knees and an all-polyethylene fixed bearing tibial component in 17 knees. Patients in the mobile bearing group were significantly younger (t test; p< 0.0001) and had better AKSS knee (Mann-Whitney U test; p=0.05) and AKSS function scores (Mann-Whitney U test; p=0.005). The patients were reviewed after a minimum of 2 years (range 2 to 3.4 years). There was no significant difference between the 2 groups. There had been 3 revisions in the mobile bearing group for tibial loosening and none in the fixed bearing group (chi squared test; not significant). There was 1 tibial periprosthetic fracture in the fixed bearing group. This study shows that the choice of bearing type makes little difference in clinical outcome or range of motion over the first 2 years when using the Preservation Knee. A similar good functional result was obtained with a fixed bearing despite the mobile bearing group being younger and having significantly better preoperative AKS knee and function scores. The 3 revisions for tibial loosening in the mobile bearing group are a concern. However, these results are short-term and there may be improved implant longevity in the long-term with mobile bearing tibial components due to reduced polyethylene wear.
The median pain score rose from 15/40 pre-operatively to 40 points at eight years. The median (MPS) rose from 10/30 points pre-operatively to 25 points at eight years. The median (OKS) rose from 18/48 pre-operatively to 38 at eight years. 87% of knees had mild or no pain at eight years. There were no cases of failure of the prosthesis itself. All 15 revisions resulted from progression of arthrititis in the tibio-femoral joint. The five-year survival rate for all causes with 86 cases at risk was 96%.
99 knees were followed for 15 years and 21 knees for 20 years. The average Bristol knee score of the surviving knees fell from 86 to 79 during the second decade.
A previous study showed an 89% 10 year survivor-ship and this is now extended to 82% at 15 years and 76.5% at 20 years.
TKA surgery creates a Pseudo-Patella Baja. PPB was introduced into 26.7% of patients. (p=0.000). The incidence of pseudo patella baja increased with the extent of soft tissue release. (p=0.000). The incidence of pseudo-patella-baja increased with increases in insert thickness. (p=0.035).
There was no correlation between the incidence of PPB and changes in outcome, as measured using the OKS and AKSS.
The lateral release rate was similar for fixed bearing (9%) and mobile bearing (9%) implants (p=0.95). Patella resurfacing resulted in lower lateral release rates when compared to patella retention (5.5% vs 13.5%; p=0.012). This difference was most marked in the mobile bearing group where the lateral release rate was 16% with patella retention compared to 3% with patella resurfacing (p=0.009).
So far, using this technique, we have operated on six patients with trochlear dysplasia and chronic patellar instability. The patients include 4 females and 2 male with an average age of 33 yrs (range 29 – 40). Average follow up is 16 months (range 8 – 24 months). There has not been any recurrence of patellar instability in the operated patients.
Conclusion: Short-term follow up of a new operative technique of troachleoplasty for patellar instability shows promising results.
Stem dissociation in modular revision knee replacement due to failure of the frictional lock of the Morse taper has been reported in the literature. However, the medium and long-term implications of stem dissociation are unknown, as clinical outcomes have not been reported. We report a series of 10 cases in which there was intra-operative dissociation of the tibial stem.
Between 1994 and 1999, 98 patients underwent revision total knee replacement for aseptic loosening at our institution. Ten of these patients were noted to have tibial stem dissociation, apparent on the immediate post-operative radiographs. The senior author (RWP) performed all procedures and used a standardized operative technique. The Co-ordinate modular knee revision system was used in all cases. The quality of the bone was noted in all the cases intra-operatively; and was graded as 1) sound bone, 2) soft but intact, 3) soft and fractured cortex.
Our study demonstrates that the tibial stem dissociation did not cause any significant detriment to the clinical outcome on minimum follow-up of six years in nine cases where the tibial metaphyseal cortical rim was intact. In one case, where the medial tibial plateau had a cortical defect, the prosthesis drifted into varus mal-alignment and the patient required a further revision for aseptic loosening. We therefore question whether long canal filling tibial stems are necessary in all revision total knee replacements particularly when the cortical rim is intact and a non-constrained poly-ethylene insert is used.
The cumulative error of implantation ranged from 6- 24 degrees in all 7 planes.
Knee society scores improved post-operatively from a mean of 52 pre-operatively to 83 at one year. Compound error also improved to a range of 6 to 10 in all 7 planes.
The range of motion increased from an average of 96 deg. (pre-op) to an average of 109 deg. at 1 year post-op for both the fixed and mobile bearing design. The management of the patella had no effect in either group.
The knee society and knee function scores increased equally for both the fixed bearing and mobile bearing knees with no differences noted.
Only patients with severe preoperative knee function showed deterioration in outcome measures from three years, all other patients maintained improvements.
The aim of this study was to measure intra-articular gentamicin levels at the 2nd stage revision following the use of an antibiotic impregnated articulating spacer.
Infected total knee replacements are a cause of considerable morbidity often requiring revision in two stages. Rings of bone cement, cement moulds and spacer devices are available for use following the initial debridement and removal of infected metalwork. The availability of antibiotic impregnated articulating spacers are potentially attractive to achieve a high local dose of antibiotic and to maintain a good range of movement.
Seven patients underwent a two stage revision of their total knee replacements. Following the initial debridement an antibiotic impregnated articulating spacer was cemented in place. At the 2nd stage revision a perioperative joint aspirate and blood sample was taken and gentamicin levels measured. The range of movement was assessed.
The average gentamicin levels were 0.72mg/l (0.24 – 2.36mg/l). A good range of movement was maintained in all cases. At these levels the gentamicin would be therapeutic.
Antibiotic impregnated articulating spacers possess several potential advantages to the revision knee surgeon by helping maintain the range of movement and provide local release of antibiotics. Their use should be considered in such cases.
The aim of this study was to determine whether there is a difference in the functional outcome between fixed and mobile bearings in total knee arthroplasty.
120 patients were randomized (computer generated) to receive either a fixed or mobile bearing P.F.C. Sigma total knee replacement. 96 patients were needed to detect a 20° difference in range of motion (ROM) with a significance level of 0.05 and a test power of 0.97. Oxford knee score (OKS) and ROM were assessed independently before and one year after surgery.
Mean ROM and Oxford knee score before and at one year after surgery for both groups are shown as preliminary results for 70 patients (follow-up expected to be completed by March 2006):
There is no statistically significant difference in the mean ROM at one year and in change in ROM between the two groups (p=0.53 and p=0.21 respectively). The findings were similar for Oxford Knee Score at one year and change in Oxford Knee Score (p=0.45 and p=0.82). There was no early aseptic loosening in either group.
The one year results suggest that there is no significant difference in functional outcome measured as ROM and Oxford Knee Score between the two types of bearing. Further follow-up will be carried out to detect any differences in the long term outcome.
The pain component of the WOMAC was negatively associated with the knee angle during sitting down and getting up from a low chair and stepping in and out of a bath (r=0.40–0.45), but not with the peak knee angle during ascending and descending a slope or walking speed. Higher scores of the activity avoidance and the helplessness scales however, were associated with reduced knee angles during descending a slope and a slower walking speed (r=0.31–0.38). Both psychosocial scales were also associated with function (r=0.39–0.45). Another important finding was that activity avoidance was not associated with pain.
The aim of this study was to evaluate whether using a predetermined entry point and standard value for valgus cut could restore normal mechanical axis of the TKA.
The study included 125 consecutive patients, who underwent TKA under care of the senior author (NJD). Details of height, weight, BMI were noted. All the radiographs were taken with the patient standing, with the knees in maximum extension, with the patella facing forward. The long leg radiographs were evaluated and the mechanical axis and anatomical axis were marked. The entry point (EP) and the angle between the anatomical and the mechanical axis of the femur ware measured, which is valgus angle of distal femoral cut (VA). Statistical analysis was done using SPSS (Table 1). Proportion of the cases with VA less than 6 degrees or more than 7 degrees were identified. Similarly cases with EP distance less than 0 and more than 5mms were also identified. Cases with VA of 6–7 degrees and EP 0–5mms were identified as one group. Correlation was performed using nonparametric tests.
The results revealed the angle between the anatomical and the mechanical axis ranges from 4 to 9.5 degrees (mean 6.8 degree and standard deviation 1.11 degree). Only 53% had an angle of between 6 and 7 degrees, with 7% of knees having an angle of less than 5 degree or greater than 8 degrees.
The site of entry of the jig showed variation from 30mms medial to the centre to 18mms lateral to the centre with the mean entry point of 5.04mms medial to centre of the notch, with a standard deviation of 8.5mms.
Overall only 33% of the knees templated would have an optimal femoral jig placement and distal femoral angle cut with an entry point in the centre of the notch or up to 5mms medial to centre and a distal valgus cut of between 6 and 7 degrees. The author feel this study gives evidence that if the mechanical axis is to be restored then long leg pre-operative radiographs should be performed and used as a key component to the pre-operative plan.
The remaining 144 patients were separated in to two groups. Group I (n=54) consisted of those patients that received one or more recorded I/A steroid injections in their operated knee in an orthopaedic clinic, rheumatology clinic or general practice setting prior to surgery. Group II (n=90) consisted of those patients with no record of receiving an I/A steroid injection prior to surgery.
In addition to those patients with confirmed deep infections, five patients underwent post-operative investigations for suspected deep infection, due to symptoms of persistent swelling or pain. All had received an I/A steroid injection pre-operatively.
The length of time between injection and subsequent post-operative infection leads us to speculate that the steroid agent might not fully dissolve, becoming trapped within the soft tissues or cystic areas of degeneration in the knee joint. Such steroids may become re-activated during operation, leading to catastrophic results. Indeed, there is experimental evidence to suggest an increased risk of infection with the intra-operative administration of steroids.
The aim of our study is to identify the organisms causing delayed deep infections following primary total knee arthroplasty in the current situation. We also compared the differences in outcome based on the infecting organism.
We undertook a retrospective study of all the patients who presented with delayed deep infection following primary total knee replacement during a six year period between April 1998 and March 2004. We analysed the infecting organism, sensitivity of the organism to antibiotics, number of surgical procedure carried out and the outcome of the infected arthroplasty based on the infecting organism. Statistical analysis was done using Fisher’s Exact test for categorical data and Mann-Whitney U test for the non-parametric numeric data.
The mean age at the time of primary arthroplasty was 69.9 years (range 46 to 92 years, SD=10.8). The mean follow-up (time since the initial knee replacement) was 77.3 months (range 27–170 months,). The mean follow-up since the last surgical procedure to treat infection was 31 months (range 14–47 months). Organisms were isolated in 27 of the 31 patients who presented with delayed deep infection. Forty-four % of the organisms isolated were multi-drug resistant with increasing incidence of Methicillin resistant Staphylococcus aureus and multi-drug resistant Staphylococcus epidermidis infections. Successful outcome following an infected total knee arthroplasty was lower compared to the previous studies where there were fewer multi-drug resistant organisms. The number of patients with satisfactory outcome is significantly lower when the organism isolated is multi-drug resistant. Patients infected by multi-drug resistant organisms undergo higher number of surgical procedures compared to patients where the organism is not multi-drug resistant. We conclude that deep infection with MRSA and Methicillin resistant Staphylococcus epidermidis are on the rise. Outcome is significantly better when the organism isolated is non resistant Staphylococcus aureus.
The purpose of this study was to determine the incidence of revision total knee replacement (TKR) within 5 years of the index procedure at a large multi-surgeon unit using a single prosthesis and to determine the cause of failure of those implants.
This was a retrospective review of all primary Kine-max Plus TKR performed at the Avon Orthopaedic Center between 1.1.1990 and 1.1.2000. Cases were identified that required revision arthroplasty in any form within 5 years of the index procedure. Case notes and Xrays were reviewed to determine causes of failure.
There were 2826 primary Kinemax Plus TKR performed during the study period. Of these 20 were known to have required revision surgery within 5 years. 8 were revised for deep infection of the prosthesis and 12 for aseptic causes. The overall incidence of premature failure of the Kinemax Plus TKR at 5 years was 0.71%. The incidence of aseptic premature failure at 5 years was 0.42%. Detailed examination of the clinical records indicated that some form of technical error at the time of the index arthroplasty was responsible for the early failure of 6 prostheses. This equates to 0.21% of the procedures performed. Aseptic loosening of the remaining 6 cases could not be attributed to a specific cause.
We have piloted a new system of purely therapist led clinics and assessed this with an anonymous patient survey.
We devised a four-part clinical risk classification system for patients undergoing primary total knee arthroplasty (PTKR) to facilitate risk estimation. We retrospectively reviewed a series of consecutive PTKRs performed by the senior author. A classification system was devised to take account of principal risk factors in PTKR (Table 1). The patients were grouped accordingly, and the following were compared:
Length of stay Postoperative complications Early post discharge follow-up assessment
Multiple regression analysis was performed. This revealed:
Similar complication rates in the NCP and CPI groups. 3-fold and 4-fold increase in the cumulative risk in the CPII, and CPIII groups respectively (p<
0.001) Increased length of stay in the CPIII group (p<
0.001).
Since 1998 the senior author (TJW) occasionally has combined a Tibial crest osteotomy and Rectus Snip-‘Open Book Approach- in revision Knee Arthroplasty where exposure was made difficult by scarring and fibrosis.
The Tibial crest osteotomy is performed as described by Whiteside and this is combined with a 3 cm oblique Rectus snip proximally. This enables the surgeon to reflect the extensor mechanism as if opening a book. This approach protects the patellar blood supply by minimising soft tissue retraction and by making the rectus snip proximal, the feeding vessels in the quadriceps are not distributed.
Revision ACL reconstruction is becoming more frequent especially in specialized centers, due to the large numbers of primary ACL procedures performed.
In two stage revisions, bone grafting of the tunnels may be undertaken if the primary position was inaccurate or if osteolysis has caused widening of the tunnels. This will allow the desired placement of the new tunnels without the risk of loss of structural integrity.
It is technically difficult to deliver and impact bone graft into the femoral tunnel with the standard surgical and arthroscopic instruments.
We describe a new technique for femoral and tibial tunnels impaction grafting in two stage ACL revisions, utilizing the OATS grafting instruments.
The appropriately sized OATS harvester is chosen 1 mm larger than the tunnel size and is used to harvest bone graft from the iliac crest through a percutaneous approach. This provides a cylindrical graft, which is delivered to the femoral tunnel through the arthroscopic portal. The inside punch of the harvester is tapped, this allows delivery of the graft in a controlled manner, and allows impaction into the tunnel. The same is repeated for the tibial tunnel while providing support for the proximal end of the tunnel.
In 1994, 62% of the injuries were sustained during soccer and rugby, in 2004 58%. In 1994, 9% of injuries were sustained during skiing, in 2004 28% – a 300% increase.
In 1994 the average age was 26.5, in 2004 33. When this increase was examined in detail the average age of the skiers was 41, the soccer players 31 and the rugby players 27.
Clearly there has been a change in the demographics of ACL injury which may have a significant impact in providing NHS services for the ACL injured patient in the UK.
One reason for not returning to pre–injury intensity of sports was that many (71.7%) expressed fears of instability though most (70%) had no instability on playing. 77.8% of non-returners who were more than 30 years age reasoned not wanting to risk re-injury compared to 36.8% in the under 30 group. More significantly, 44.4% of over 30s said they were planning to drop their sporting level anyway compared to 5.5% in the younger group.
The KT-2000 Arthrometer, mean side-to-side difference for manual maximum displacement was 1 mm (range, 0 to 3). Anterior compliance index mean side-to-side difference was1 (range −1 to 3), Quadriceps active displacement tests mean side-to-side difference was.5 [range −1 to 2]. The mean International Knee Documentation Committee knee score was 89 (range, 33.3 to 100).
Infection following total knee arthroplasty is a serious complication. Recently there has been increasing incidence of isolation of multi-drug resistant bacteria from peri-prosthetic infections. The aim of our study is to identify the organisms causing delayed deep infections following primary total knee arthroplasty in the current situation. We also compared the differences in outcome based on the infecting organism. We undertook a retrospective study of all the patients who presented with delayed deep infection following primary total knee replacement during a six year period between April 1998 and March 2004. Organisms were isolated in 27 of the 31 patients who presented with delayed deep infection. Forty-four % of the organisms isolated were multi-drug resistant with increasing incidence of Methicillin resistant Staphylococcus aureus and multi-drug resistant Staphylococcus epidermidis infections. Successful outcome following an infected total knee arthroplasty was lower compared to the previous studies where there were fewer multi-drug resistant organisms. The average number of surgical procedures carried out was significantly higher when the organism isolated was multi-drug resistant. The number of patients with satisfactory outcome is significantly lower when the organism isolated is multi-drug resistant.
All the patients started knee exercise with CPM from next day and allowed to bear partial weight on the operated knee for 8 weeks.
Arthroscopic surgery is a common intervention for osteoarthritis of the knee. However, the benefits from such an intervention are not clear. The purpose of the study was to perform a questionnaire survey of orthopaedic surgeons of Wales to analyse the practice of arthroscopy for osteoarthritic knee.
Over a three-month period, a postal survey was conducted of all hospital orthopaedic consultants in Wales. Of a total of 62 questions sent we received a reply of 37. 31 surgeons perform arthroscopic lavage or debride-ment. 4 surgeons perform arthroscopic surgery for symptomatic meniscal tear only. There was no defined protocol regarding the management. Early OA was the commonest indication (18). Arthroscopic lavage (17) was equally popular to lavage and debridement (16). 6 respondents like to perform the surgery themselves while the majority would allow a middle grade surgeon to operate with or without supervision. 26 surgeons felt that the results of the procedure are unpredictable, but still continued to perform it. Only 6 surgeons felt a continued relevance of the procedure.
Arthroscopic surgery is a commonly performed symptomatic treatment for arthritic knee. It bears a significant financial commitment. 266 arthroscopic knee surgery were performed annually in a district general hospital, of whom 115 were arthroscopic washout. Average cost of each operation is £1000. The physiological basis for arthroscopic washout is not clear. A majority of the Welsh surgeons have reservations about this procedure. In spite of evidence of limited usefulness, it is still performed widely.
METHODS AND RESULTS: 1700 cases were reviewed retrospectively. Of the respondents to the questionnaire, 457 (65%) patients had dorsal, 255 patients (35%) volar wrist ganglia.
Dorsal ganglia had been treated by observation in 99 (22.4%), aspiration in 57 (12.9%), aspiration plus injection in 37 (8.4%) or surgery in 249 (56.3%) of the cases. The analysis showed that the recurrence rates were 39%, 74.5%, 28.5%, and 35% respectively for each type of treatment. Scar tenderness was present in more than half of surgically treated patients. Repeat surgery was performed in 20 out of 70 (28.5%) recurrent cases. The satisfaction rate did not correlate with the recurrence rate.
For volar ganglia, treatment had been observation in 49 (19.2%), aspiration in 13 (5%), aspiration plus injection in 12 (4.7%) or surgery in 153 (60%) of the cases. The analysis showed that the recurrence rates were 28.5%, 92%, 25.5%, and 33.3% respectively. Scar tenderness was present in 67% and sensory loss in 32% of surgically treated patients. Repeat surgery was only performed in 18 out of 52 (34.6%) recurrences. The satisfaction rate was highest in the aspiration and injection group, which had the lowest recurrence rate among all treatment modalities.
To compare outcome between the medial and posterior approaches for the surgical treatment of supracondy-lar fractures when performed by two experienced surgeons.
A retrospective analysis of 45 children, mean age of 5.5 years (2.5-11 years), treated for closed Wilkins IIB/III supracondylar fractures without vascular deficit between January 1999 and December 2004. Twenty-one and twenty-four children were treated using the medial and posterior approaches respectively. The medial approach is quicker but technically demanding. The posterior approach is easier but cuts through the intact posterior structures. In both groups the fracture was stabilised using crossed K-wires and the arm was immobilised in an above elbow backslab for 3 to 4 weeks. Follow-up was at 3 to 4 weeks, 3, 6, and 9 months, and at 1 year. The results were assessed clinically using Flynn’s classification and radiologically using the metaphyseal-diaphyseal and humerocapitellar angles.
There was no post-operative infection or redisplace-ment. Clinically, the medial approach gave 18 excellent, 2 good, and one fair result, and the posterior approach gave 21 excellent, 2 good, and one fair result (P> 0.50). Radiologically, the medial approach gave 18 excellent and 3 good results, and the posterior approach gave 20 excellent and 4 good results (P> 0.50).
We found no significant difference in outcome between the two approaches, both giving mostly excellent long term results. Each approach has its known merits and drawbacks. This type of fracture needs an experienced surgeon comfortable with his preferred approach.
Arthroscopic procedure involved pre operative skin markings. Ankle distraction is used. An anterior approach used with standard Anteromedial and antero-lateral portals.
Fifty five (69%) patients had soft tissue impingement, and 25 (31%) patients had osteoarthritic degenerative changes.
Seven (9%) patients had further major surgery and 6 (8%) had repeat arthroscopy.
The surgery was required for 7 arthritic ankles (7/25).
28% of osteoarthritic patients progress to major ankle surgery, within 5 years of arthroscopic treatment. None of patients with impingement symptoms required further major surgery.
No statistical significance between those under 50 and those over 50 years in OA group
12 patients (24%) had discharge, pin tract granulation, loosening, out of which 4 required antibiotic. Out of 12 only 2 (4%) has positive swab culture requiring Intravenous antibiotics.
3 patients (6%) had symptoms suggesting superficial radial nerve damage of which 2 recovered completely after pin removal. One had residual symptom, put on waiting list but symptoms got better and she refused further treatment.
9 patients (18%) had stiffness out of which only 3 (6%) had residual stiffness at the end of 6 months. However this stiffness can not be attributable to k-wiring alone (?fracture intra articular).
CRPS was noted in 1 patient (2%) and recovered after prompt physiotherapy. There were no cases of deep infection, osteomyelitis, tendon rupture, pin migration or significant loss of position in our study.
The change in management that the CT scan brought about was also assessed for each of the observers using the McNemars test. The CT scan did not make any significant difference to the decision made based on the plain radiographs, on whether to operate or not.
A Cochran Q test used to assess the variability of the decisions, showed that there was more inter-observer variability in decision making, using the CT based assessment (Q=9.50, p=0.009) as compared to plain radiographs (Q=3.84, p=0.14).
The purpose of this study was to evaluate the outcome of internal fixation for undisplaced intracapsular fracture neck of femur in elderly group of patients with a view to evaluate the incidence of definitive procedure at a later date.
The method used for evaluation was retrospective study of 46 consecutive cases within one year, operated for Garden 1 or 2 type of fractures, who were followed up for upto 2 years. Postoperative complications, the need for further intervention and relationship with age and preoperative ASA grade was assessed.
Results of the study were quite interesting. 74% patients were above the age of 60 years. 60% of them (30 out of total 46) stayed in the wards for more then one week, due to medical problems. 35% (16 out of total 46) required further intervention in form of hemi-arthroplasty or total joint replacement, either due to implant failure or avascular necrosis. 63% of those who required further intervention 10 out of 16) were ASA grade 3 or above.
Conclusion of the study was that although internal fixation is a relatively small procedure, the complication rate, requiring further intervention was higher then anticipated. There is a role of primary definitive procedure in certain number of cases, specially those having higher anaesthetic risk i.e. ASA grade 3 or above.
Periprosthetic fracture of the femur after hip arthroplasty is a difficult problem. Management depends on different clinical factors and these are fractures are managed at District General Hospitals.
Present series is of fifty such fractures presenting between 1999 and 2004 in two District General Hospitals in England. Number of female patients were more than males and majority of patients sustained these injuries after trivial fall.
Outcome of management are analysed according to modified ‘Tower and Beals’ criteria (1999).
Eleven patients lost to follow-up, twelve patients died (mortality was twenty-four percent) during follow-up. Twenty-one patients progressed to clinical and radiological union at an average of eight and eleven months respectively. Six patients are under follow-up.
Although several results are published in literature but the present result is comparable to the most literatures. If certain principles are followed comparable results can be obtained in District General Hospitals by Surgeons with a special interest in the management of these fractures.
Materials & Methods: Our study included 117 consecutive elbow arthroscopies performed by two surgeons for a period of 18 months from January 2002 to July 2003.
All patients were treated non operatively before undergoing arthroscopy. Conservative treatment included rest, activity modification, physiotherapy including ultrasound bracing, NSAIDS and corticoste-riod injection.
In the case of resistant tennis elbow the existence of a radial head synovial plica should be considered. Our study concludes that by resecting the synovial plical fold will relieve the pain and restore the elbow motion.
Subtrochanteric fracture following cannulated screws may occur without trauma. Osteoporosis may have a major role to play. We recommend one screw infe-riorioly and entry point above the lesser trochanter as reported previously.
Among the hypokalemic group the mean preopera-tive potassium was 3.69mmol/l and the mean postoperative potassium was 3.19mmol/l. The t-test showed a statistically significant difference between mean pre and postoperative potassium levels. (P< 0.0001). High association was found with hypokalemia and post-operative dextrose infusion (38%). 50% of patients on diuretics developed hypokalemia post operatively. Interestingly, only 18% of these were hypokalemic pre operatively.
In patients with multiple medical problems, like diabetes, hypertension and CVA, high incidence of hypokalemia was found. (38% had 2 or more medical problems).
No significance in the mortality rate was found in fracture neck of femur patients with and without postoperative hypokalemia (40% vs. 39% at 3yrs).
Proximal humeral fractures are common injuries but there is no general agreement on the best method for fixing unstable and displaced 3 & 4 part fractures. A new implant – Proximal Humeral Internal Locking System (PHILOS) – has recently been introduced to fix these fractures. The aim of this study was to assess the effectiveness of the PHILOS plate in the surgical treatment of these fractures.
We operated upon 36 patients between March 2002 and December 2004. 33 of them were available for follow up, which ranged from 12–45 months. Assessment at follow up included radiological review, Constant and DASH scoring.
While recovery of movements and relief in pain was satisfactory, the strength of shoulder did not recover fully in any patient. There were two failures in our series, one due to breakage of plate. 4 patients have shown radiological signs of avascular necrosis of humeral head. The plate was removed in 4 patients due to impingement and / or mechanical block in abduction. Another 2 patients had to undergo arthroscopic subacromial decompression for the same reasons. We encountered the problem of cold welding and distortion of screw heads, while removing the PHILOS plate.
The broken plate was subjected to biomechanical and metallurgical analysis, which revealed that the plate is inherently weak at the site of failure.
The PHILOS plate does have inherent advantages over other implants for fixation of 3 and 4 part proximal humeral fractures but we are not convinced about its strength. Design of its proximal screws also appears less than satisfactory. The plate may cause impingement in some patients necessitating its removal later on, which itself may not be easy.
Bone grafting is used extensively in orthopaedic reconstructive surgery. Revision hip arthroplasty often presents surgeons with difficult bone loss problems, which can sometimes be addressed using donated bone. This need for bone graft has increased in recent years with greater numbers of joint replacements and increasing life expectancy after replacement, particularly as prostheses are being implanted into younger patients. Current practice of bone banking involves careful donor selection, stringent screening tests and internal safety systems in bone banks to prevent the ever present threat of communicable diseases. Introduction of strict monitoring systems to prevent allograft-related diseases has rendered a significant number of primary hip replacement patients unsuitable for bone donation. This study audited the practice of bone banking at Portsmouth Hospitals NHS Trust to look into various factors responsible for exclusion of patients from bone banking. All 55 patients underwent screening in pre-operative assessment clinics using standard Proforma to assess their suitability for femoral head donation during the course of their primary hip replacement surgery. After the initial screening stage 33 patients (60%) were excluded due to variety of reasons. The majority of those excluded (23 patients) were not accepted as donors because of their potential risk of transmission of disease to the recipients. The situation is likely to become worse in future as the incidence of communicable diseases is rising in the UK. Alternative sources of bone grafts should be explored in future to meet the demands for, example auto-banking.
The purpose of this study was to review the midterm results of HAC coated bipolar hemiarthroplasty in patients with displaced intracapsular fracture neck of femur in elderly patients.
There were 264 patients with 274 fractures from November, 2001, to June, 2004. The operations were performed by employing a similar technique and anterolateral approach. Postoperative treatment was same. The mobility was assessed by ambulation. Pain was evaluated using a visual analogue scale and clinical evaluations were performed using the Harris Hip Scoring System.
The mean age of 142 survived patients reviewed in the study was 77.5 years (range 61-89 years) at the time of operation and mean follow-up was 25 months (range 18-48 months). Hundred and twenty six patients had no or mild occasional pain but no restriction of activity. Ninety of the ninety eight able to walk independently or with one stick before fracture were doing the same. The surviving implants were radiographically stable and demonstrated evidence of osseointegration and no acetabular wear. Harris hip score averaged 84 points. Fourteen patients (10%) scored 90-100, 80 patients (56%) scored 80-89, 42 patients (30%) scored 70-79, and 6 patients (4%) scored less than 70.
We conclude that patients who score grade 1-3 of American Society of Anaesthesiologist and are mobile preoperatively outside their own home either independently or with one stick are better treated with HAC coated bipolar hemiarthroplasty with extra benefit of easy and quick conversion to total hip replacement if required in future.
20/21 cases had no superficial or deep infection. 62 years old patient with Schatzker IV tibial plateau fracture had deep infection requiring wound debridement and removal of implant which revealed unabsorbed allograft at one year post op which also cleared the infection.
We recommend using allograft bone in elderly patients to reduce morbidity by avoiding one more surgery of obtaining bone graft.
Allograft bone in elderly used with internal fixation also provides a reasonable structural support along with it osteoinductive properties.
This study was done to determine the effectiveness of percutaneous autologous bone marrow injection in fracture healing and to determine if centrifuged bone marrow is more effective in bone healing as compared to uncentrifuged marrow.
This is a randomized interventional trial of 106 patients who had bone marrow injection. The study was done in 2 parts. In the first part, 51 patients were divided into three groups – a) Fresh fractures,(within 6 weeks of injury) b) Delayed union – (8 to 12 weeks after injury) c) Non union – more than 16 weeks after injury. All patients in the first part of the study underwent percutaneous autologous bone marrow injection and were followed up at 6,8,10 and 12 weeks and every 4th week thereafter. Forty seven out of 51 patients united. The second part of the study was done to compare centrifuged and uncentrifuged bone marrow injections. Fifty five patients having either tibial or femoral fractures were divided into two groups, centrifuged and uncentri-fuged and appropriate marrow injection was done. All patients were followed up every 6 weeks till 36 weeks. 48 patients out of 55 united. Equal number of patients united in the centrifuged and uncentrifuged group.
We conclude that percutaneous autologous bone marrow injection is a simple and effective tool which can be used for fracture healing and centrifugation of bone marrow yields no added advantage in bone healing.
Materials and Methods: 9 male non professional athletes of mean age 38 years (range 23-73) presented with closed rupture were treated surgically using achillon technique were treated with same preoperative cast, post operative orthosis and rehabilitation protocol. All the patients had suture removed at 10 days after the surgery and followed up at 3 weeks, 8 weeks, 12 weeks and 6 months and yearly.
The authors report their preliminary experience with a minimum of one year follow –up of hydroxyapatite coating as the means of fixation of the femoral head in hip resurfacing.
Between Dec 2003 and Dec 2004, of the 23 cases performed by the senior author,22 were available for follow up,15 were women (68.2%) and 7 were men (31.8). The femoral and acetabular components of the uncemented version of the CORMET 2000(Corin,Cire ncester,UK) were used. The surgical approach was the Hardinge approach in all cases. Patients were assessed pre-operatively for pain and function,using the Harris Hip Score. Post operatively they were assessed in clinic with x rays at 6 weeks,6 months and annually thereafter. X rays were evaluated for pre and post op neck shaft angle,giving an indication of varus or valgus placement of the head prosthesis. The lateral view was assessed to reveal anterior or posterior tilting of the prosthesis. Neck thinning was evaluated by measuring the ratio of the metal cup and bony neck diameters at the cup neck junction, recorded post op and at one year.
None of the femoral implants were placed in varus. Only one case had inferior notching, which had remodelled at one year. In the lateral view none of the cups showed a displacement of more than ten degrees in the AP direction. There were no stem lucencies or signs of femoral implant migration in any of the cases. None of our cases showed neck thinning (change in ratio greater than 10%). Uncemented femoral implant in a metal on metal resurfacing hip replacement appears to perform well and shows no catastrophic problems at the short term one year follow up. Longer follow up studies are necessary
Unilateral musculoskeletal below knee injuries occur with great frequency. Patients who cannot bear weight on an injured limb usually mobilise with standard crutches. However when the patient also has an upper limb injury, mobilisation may be impossible and can result in a lengthy in-patient stay. We present its value in facilitating early discharge in patients with both upper and lower limb injuries. We show the cost benefit of the saving in in-patient stay that the hands free crutch provides. We present our experience in which this innovative crutch was used and discuss the potential of this device to be used more often in orthopaedic surgery.
All patients underwent an initial application of Orthofix external fixator with pins in the proximal and middle phalanx. The patients were advised to gradually distract the device 3-4 times a day, for two weeks. They were then brought back for removal of fixator and partial fasciectomy with closure of skin by V-Y plasty.
The results were assessed in thirteen patients, as two were lost to follow-up. The mean follow-up period was 30 months (6 – 64 months). The total mean preopera-tive extension deficit improved from 130 degrees to 38 degrees postop.; PIP joint deformity improved from a mean of 77 degrees to 33 degrees postop. and the mean TRAM (Total range of active movements) improved from 108 degrees to 165 degrees.
Functional assessment was done using Michigan Hand Outcome Questionnaire. Overall improvement in hand function was from a preoperative 34% to a postoperative 89%.; aesthetic improvement from a preop. of 46% to a postop of 81% and pain improvement from a preop of 66% to a postop of 96%.
One patient had recurrence, one had features of RSD (Reflex Sympathetic Dystrophy) and one had to undergo amputation due to poor tolerance and persistent infection.
The aetiology and pathophysiology of non-union is still unclear, but in this condition there is an abnormal bone metabolism. The paracrine matrix RAS has been implicated in the regulation of bone remodeling and injury responses, possibly via its effects on kinins. The influence of the local RAS or the genetic influence of the ACE/ BK2R genes to bone remodelling may thus be central to the disorder, or augmented in these conditions. We thus compared the distribution of the ACE I/D and BK2R “+9/-9” functional polymorphisms in patients with non-union and compared them to appropriate control.
Gene analysis was performed on buccal cells collected from all subjects and the data was analysed for 59 patients (46 males, 13 females; mean age 40.1±15.7 years) with non-union and 81 control subjects (49 males, 32 females; mean age 51.4±22.81 years. The overall genotype distribution was consistent with Hardy-Wein-berg equilibrium for the overall and individual groups for ACE (
As the -9 allele is associated with greater gene transcription and higher mRNA expression of the receptor we combined the -9/-9 homozygous and -9/+9 heterozygous groups and compared them with the homozygous +9/+9 groups. This showed a significant difference between the non-union and control groups, with the +9/+9 homozygous being less prominent in the former (
The B2BKR -9 allele is associated with the incidence of non-union in fracture healing, in this first study to address this question. We found no association with either the
In conclusion, with previous findings that the absence of the -9 allele of the B2BKR +9/-9 polymorphism is associated with greater gene transcription and higher mRNA expression of the receptor our findings are suggestive that increased BK activity via the B2BKR may predispose to the development of non-union.
MATERIAL AND METHODS: We studied 123 ultrasound and looked for its use in different hand and wrist conditions. These were categorized in different groups such as diagnostic, anatomical and therapeutical.
To assess if paediatric patients are getting adequate gonadal protection whilst undergoing pelvic X-rays.
A retrospective study of 100 AP pelvic X-rays in 62 consecutive paediatric patients was performed. All children 16 years and under (mean = 8 years) who had an AP pelvic X-ray at our institution between 1st April 2004 and 1st July 2005 were included in the study. When reviewing the X-rays, the manufacturer’s guidelines for ideal shield size and position were strictly followed to assess whether adequate gonadal protection was being achieved (the lead shield must be completely covering the true pelvis in girls and the scrotum in boys). A subsequent questionnaire survey involving 20 radiographers was carried out.
In 78 cases gonadal protection was inadequate. This was unrelated to the child’s age or sex. In 72 cases shield position and in 11 cases shield size was incorrect. The survey showed that 40% of radiographers believed that the gonadal shield was either difficult to use or had a poor design. Twenty percent felt they had received inadequate training.
Gonadal shields reduce radiation exposure of the reproductive organs during pelvic X-rays. Many designs are available on the market but not all designs function adequately. Our study showed that a poor design of gonadal shield can cause unnecessary radiation exposure. We present this audit to make people aware of this poor design and recommend that a detailed market survey prior to buying such equipment and subsequent training of staff in its proper use must be carried out.
We wish to report the use of a modified ‘Y-V’ medial capsular repair in association with Chevron osteotomy fixed rigidly with Barouk screw for Hallux valgus in 45 patients (52 feet) aged 16 to 70 years (mean 47 years) between July 2004 and September 2005. All patients were retrospectively reviewed by questionnaire, physical examination (American Orthopaedic Foot and Ankle Society score) and comparison of preoperative and post operative x rays.
Using this technique none of the patients required additional immobilization apart from wool and crepe bandage following surgery. All osteotomies healed without any problem. There was no deep infection reported in this series. There were two superficial infection treated with oral antibiotics. There is no recurrence of deformity so far. At an average of six months follow up American Orthopaedic Foot and Ankle Society score improved significantly. Intermetatarsal (IM) angle and the hallux valgus (HV) angles were also improved considerably.
Stabilization of Chevron osteotomy with k wires, plaster of Paris is well known but these techniques have problems of infection and stiffness. Osteotomies carried out without any stabilization has high recurrence rate. Fixation of osteotomy with Barouk screw is a very simple procedure, which not only gives stability and compression to osteotomy but also reduces need for any plaster immobilization thus speed up rehabilitation. This also gives extra confidence to surgeon to allow patient for early weight bearing and mobilization.
We also recommend the use of modified ‘Y-V’ medial capsular repair to correct the hallux valgus angle and reduce the meta tarso-phalangeal joint leading to reduction in possibility of recurrence.
The standard plane imaging of Graf and the dynamic methods of Harcke are well established methods in assessing hip dysplasia but give limited information in the flexed-abducted treatment position used in the Pavlik harness. The femoral head may sit on the edge of the acetabulum in a flexed position and only reduce when the hips are abducted. This may mean that hips, which reduce when abducted in the Pavlik harness, appear subluxed when scanned in neutral abduction. Harness treatment may thereby be abandoned prematurely due to the failure to confirm reduction. This study identifies ultrasound landmarks on an anterior hip scan which could be used to confirm reduction of the hip in Pavlik Harness.
Hips of a newborn piglet were scanned, imaged with magnetic resonance and x-rayed both before and after anatomical dissection. Radiographic markers delineated the position of the tri-radiate cartilage and potential ultrasound landmarks identified to help confirm hip reduction in the flexed-abducted position. Porcine imaging was then compared with that of a human newborn.
The porcine model corresponded well to human imaging and we were able to establish a landmark, the “Ischial Limb”, which corresponds to the ossification front delineating the posterior ischial edge of the tri-radiate cartilage. This could clearly be seen on anterior hip ultrasound of both the porcine and human hip. This landmark can be used to confirm the hip is reduced by reference to the centre of the femoral head.
We would recommend anterior hip scanning using the “Ischial Limb” as a reference point to confirm hip reduction in Pavlik harness. This simple method is a useful adjunct to conventional ultrasound scanning in the harness treatment of hip instability.
We prospectively studied 15 proximal tibial and 30 distal femoral fractures treated with the Less Invasive Stabilisation System for periarticular fractures about the knee.
Of these 45 fractures, one patient returned to Russia and was thus lost to follow up. The mean age of the remaining patients was 64.4 years (range 15–94 years). There were 26 females and 13 males. All fractures were classified according to the AO classification.
We found the use of temporary external fixation and mobile radiolucent wedge leg supports very helpful during surgery for these cases. We developed an increasingly aggressive postoperative mobilisation regime with increased experience of using this fixation technique.
Functional assessment was performed using the Schatzker and Lambert scores. The average time to union was 14.78 weeks (range 10– 28 weeks). 43 fractures have united with one fracture showing signs of delayed union. There were two implant failures, two deep vein thrombosis and two compartment syndromes. Five patients died of unrelated causes and without problems relating to their fracture.
We conclude that the Less Invasive Stabilisation System is a satisfactory method of treating these complex and difficult fractures about the knee with a high rate of union and good functional outcome.
The use of arthroplasty registers was initiated by Sweden in 1979. The practice has been adopted globally as best practice for recording the outcome of joint replacement surgery and for identifying early problems. The Trent and Wales Arthroplasty Audit Group began in 1990 and have recently produced outcome results. We have analysed the short-term outcomes of arthroplasty procedures at a DGH in order to assess comparability to this “gold-standard”.
In 2004, 231 primary arthroplasties were performed, by the two senior authors, at Musgrove Park Hospital (149 THR, 82 TKR). There was an overall complication rate of 8.7%. There was 1 periprosthetic infection in a THR that required revision (0.043%). 9 patients developed wound complications, principally superficial infections and haematoma formation. 2 patients, both THR developed, thromboembolic complications, one DVT and one pulmonary embolus. There was one periprosthetic fracture around a THR. The dislocation rate for THR was 3.35% (5/149). 3 of these were performed through a posterior approach and 2 through an anterolateral. 3 have required revision surgery.
We have demonstrated comparable results following joint arthroplasty to published teaching hospital series. We have shown that adequate infrastructure can exist in smaller units to accurately record outcome data following arthroplasty surgery.
Collecting outcome scores in paper form is fraught with difficulty. We have assessed the feasibility of and patient’s attitude towards entering scores using a touchscreen.
A touchscreen was installed in the orthopaedic outpatient clinic. If relevant, patients were asked to complete either an Oswestry Disability Index (ODI) or Oxford Shoulder Score (OSS) using the screen. Patients were given written instructions and their hospital number by the receptionist who had no further input. Scores were completed with two identifiers. A paper questionnaire was used to assess computer experience and attitude towards the touchscreen.
Results: 1377 patients, average age 51 successfully completed a score in the first 12 months. 1/3 were over 60. 93% correctly entered their hospital number and date of birth, falling to 85% in patients over 70. All patients were identifiable. The average time to complete the scores was 4 minutes rising with age.
Of 170 patients completing the questionnaire, 1/3 had little or no experience of computers and 1/3 were over 60. 93% of patients were willing to repeat the score using the touchscreen to monitor progress. 2/3 found it easier to use than expected. Only 10% would prefer a paper score. These results were maintained among patients over 60. Only 2 were unable to complete the score and 80 % of those potentially eligible did so. The remainder were called to clinic before the touchscreen was free.
Conclusion: Orthopaedic outcome scores can be collected in very large volumes using a touchscreen. Data is then in an immediately usable form. The method is acceptable to the patients, independent of age and computer experience. Even in the oldest patients the accuracy is higher than for paper versions of the score. Combined with operative data, this simple method has the potential to provide a very powerful audit tool indeed.
The collarless polished tapered stem (CPT) is a double tapered, cemented femoral component designed for primary hip replacement and as a revision stem for impaction bone grafting. We report outcome at a minimum of 10 years (mean 11 years 1 month).
Of 191 consecutive primary hip replacements in 174 patients, implanted using contemporary cementing techniques, 63 patients died before 10 years (68 hips). None of these stems had been revised or had radiological signs of failure at their last follow-up. Only one patient (two hips) was lost to radiological follow-up, hence complete radiological data was available on 121 hips and clinical follow-up on 123 hips. The fate of all the hips is known.
Survivorship with revision of the femoral component for aseptic loosening as the endpoint was 100%. The Harris hip scores were good or excellent in 75% of the patients with a mean of 86. All the stems subsided vertically within the cement mantle at a mean rate of 0.18mm per year, stabilising to a mean total of 1.95 mm (0.21–24 mm) after a mean of 11 years 1 month. Unlike Exeter stems there was no change in the alignment of the stems. There was excellent preservation of proximal bone and an extremely low (< 2%) incidence of loosening at the cement bone interface.
The study confirms that the CPT subsides within the cement mantle, but without failing. It performs at-least as well as the best stems currently available.
A prospective audit was conducted at an associate teaching hospital in the south west to assess the outcome of operative treatment of ankle fractures of all patients over the age of 50 years in the last 2 years.
The aim of the study was to assess whether change in timing of surgery for ankle factures in accordance with the CEPOD guidelines has affected the outcome in terms of early complications. This is a follow up paper to the one published from this institution in 1994 (data 1988 to 1989). Since then the CEPOD rules have led to changes in theatre protocols, so very few ankles are fixed out of hours. Over this period there has been the emergence of MRSA which was not a problem in the 1990s.
We retrospectively reviewed the notes and x-rays for 107 consecutive patients older than 50 years who had their ankles fixed over a period of 2 years spanning 2003 to 2004. Our series had 12.1% incidence of clinical infections, 15.9% delayed wound healing as compared to 1.8% and 5.2% in previous publication from this institution. In our study 17.7% of ankles were fixed within 24 hours as opposed to 84.2 % in the previous paper. All of the infected wounds (100%) occurred in patients who had their operations 48hrs or more post injury. We also came across 2 cases of MRSA infection in our series.
We are concerned that changes in CEPOD rules as well as new hospital practice has resulted in delays in time to fixation. This seems to be the only variable to result in increased infection rates and delays in wound healing leading to increase in hospital stay and reoperations.
Scarf osteotomy improves hallux valgus and can be used for deformities with large intermetatarsal angles. It is designed to minimise shortening of the first ray. The aim of this radiographic analysis was to assess the outcome of patients undergoing Scarf osteotomy at the Royal Cornwall Hospital.
The initial 18 consecutive cases performed by the senior author were analysed using the guidelines recommended by the American Foot and Ankle Society. Standardised anterior-posterior radiographs of the foot were compared pre-operatively and at 6 weeks postoperatively. Measurements of the intermetatarsal angle (IMA), hallux valgus angle (HVA), joint congruency angle (JCA), distal metatarsal articular angle (DMAA), sesamoid position and metatarsal length were used to assess any improvement.
The results showed a significant median reduction of the IMA of 70, HVA of 180, JCA of 50, and the DMAA of 30 (all p values < 0.001). The medial sesamoid position in relation to the first metatarsal also improved from a mean value of 2.28 to 1 using the American Foot and Ankle Society grading system. There was no shortening of metatarsal length as measured using the Hardy and Clapham method.
This study shows that the radiographic outcome of Scarf osteotomy at the Royal Cornwall Hospital compares favourably with that found in the literature. It provides effective correction of moderate to large intermetatarsal angles.
Magnetic Resonance Imaging (MRI) is gaining popularity for the evaluation of acute wrist injuries, but findings may be confusing with uncertain clinical significance. The presence of bone marrow oedema but no fracture following trauma has been described in the knee and referred to as a bone bruise. The clinical implications of similar findings in the scaphoid have not been described.
This study aims to describe the clinical and radiological findings of an acute wrist injury known as the scaphoid bone bruise. An MRI classification is proposed, and the outcome described.
Between April 2000 and October 2004 all patients who underwent MRI scanning following an acute injury for suspected scaphoid fracture were considered for this study. The scaphoid bone bruise was treated with a degree of caution and the injured limb placed in a below elbow cast for six weeks. Review was arranged at three months when, if symptomatic, a further MRI was performed. A descriptive grading system depending on the extent of the bone bruise was developed.
41 patients were included in the study. At three months 26 were asymptomatic. Seven defaulted from follow-up. Eight patients were still symptomatic and underwent further MRI scan. The bone bruise was classified into four grades according to the degree of oedema found on MRI. Seven patients were grade 1, 18 patients were grade 2, 11 grade 3, and the remaining five grade 4. Of the eight patients who underwent repeat MRI scanning all showed improvement of the bone bruise. At six months only 2 patients remained symptomatic.
While healing around the knee is seldom a problem, the possibility that scaphoid bone bruise may be a precursor to scaphoid non-union needs to be excluded. This study suggests that scaphoid bone bruise is a benign injury with predictable recovery over time and is unlikely to result in long-term morbidity in the form of non-union. It may be feasible to mobilise these injuries much sooner. However, further study with longer follow-up and repeat MRI scans is necessary to be confident that caution about these injuries is unnecessary.
Between 1996 and 2004, the senior author performed 58 total elbow arthroplasties in 44 patients (10 males, 34 females) using the GSB III implant. These were reviewed and the outcome assessed through the use of a patient-answered questionnaire and clinical and radiological review. Mean age was 65 (49 to 84 years). Indications for surgery included rheumatoid arthritis (46 elbows) and post-traumatic osteoarthritis (11 elbows). Mean F/up was 4.1 years (0.8 to 8.5 years). Four patients had died (six elbows) and four patients (four elbows) were unavailable for review. Two of the implants had been revised (1x aseptic loosening, 1x deep infection), leaving a total of 46 elbows available for review. The survival rate at a mean of four years was 98% with aseptic loosening as the endpoint.
Complications included one case of intraoperative fracture and one persistent ulnar neuritis. Overall patient satisfaction was high. The mean Mayo Elbow Performance Score was 83 out of 100 (range, 34 to 100) and mean Liverpool Elbow Score was 8 out of 10 (range, 1 to 10).
This paper describes the methods of working and analyses the early results of nearly a thousand joint replacements implanted between May 2005 and April 2006. It is the first set of such results to be become available.
Open reduction of DDH is indicated in late presenting cases and those who fail Pavlik Harness treatment, if closed reduction is unsuccessful. Recognised techniques involve excision of the ligamentum teres to allow maximal medialisation of the femoral head into the acetabulum.
We describe a new technique in which the ligament’s femoral attachment is preserved and the medial end is passed through the incised transverse ligament. Gentle traction on the medial end is used to aid reduction and when sutured to the anterior capsule, the reduction is stabilised.
We present our operative experience and early follow up of 8 cases.
In the deceased patients 2 patients had undergone revision and the remaining patients had died of causes unrelated to the surgery with the prosthesis intact. There was 1 permanent ulnar nerve palsy and two deep infections one requiring debridement. Eight of the original 44 primaries required revision, 3 for fractures and 5 for loosening.
Hip osteoarthritis is uncommon in active military personnel but can be extremely debilitating. Previously in such cases total hip replacement was usually delayed as long as possible. The two main reasons for such reluctance were that these persons would be graded P7 Permanent after total hip replacement and that the amount of physical activity an active military person does would lead to early loosening of implant and revision surgery. Resurfacing Arthroplasty has allowed us to take an earlier and more interventional approach in younger active patients.
We describe our early results of 18 hip resurfacing operations in active serving military personnel. Average age was 48 years. All 18 were done in MDHU Northallerton by one in-service orthopaedic consultant in 2004 and 2005. There were no serious complications; average length of stay was 5.5 days. Specifically there were no fractured necks of femur and there were no early signs of component loosening. Final grading after six months was P3.
Hence we now recommend that in selected active military personnel where anatomy permits early hip resurfacing should be considered rather than a conventional hip replacement.
It is the authors’ view that hindfoot stiffness in secondary cases of dorsal bunion causes an inability of the footto compensate for an abnormal position of the forefoot- the 1st ray must compensate by flexion of the hallux to allow the foot to adopt a plantigrade position.
Eligible patients randomised to one of four arms of the study: control (normal analgesia and/or non-steroidal anti-inflammatory medication), a specified and repeatable Exercise and Manual Therapy Package (EMTP), a course of up to three subacromial steroid injections or both the EMTP and the steroid injections. Follow-up was for 18 weeks, with postal questionnaire at one year.
The primary outcome measure was the Oxford Shoulder Score (OSS).
By analysis of covariance, no significant differences were found between the OSS scores or SF-36 (physical health total) at the beginning and end of the trial, or at one year. Two patients in the injection group went on to surgery, along with one each in the control and EMTP groups. No significant differences were found between treatment groups.
Osteochondral lesions (OCLs) of the talus are not uncommon, the diagnosis of which requires a high index of suspicion and is often delayed. The purpose of this presentation is to raise awareness and discuss treatment outcomes of OCLs.
All patient notes with a diagnosis of talar OCL over a 12-month period were retrospectively analysed. A telephone questionnaire was then performed in which patients were asked to compare current symptoms to pre-operative symptoms using a numerical scoring system.
There were thirteen patients with a mean age of 31. A history of trauma was present in eleven (85%) and all had activity related pain. OCLs were evident on plain radiographs in six (46%). The diagnosis was made in the remainder on MRI or at arthroscopy. Median time between initial orthopaedic assessment and diagnosis was 4 months (0–100). The OCLs were medial in six (46%) and lateral in seven (54%). Eleven patients were treated with excision and penetration of subchondral bone, 1 underwent open fixation and 1 had an isolated chondral lesion treated conservatively. Mean follow-up was 6 months (2–14). Seven (54%) had minimal or no symptoms and three (23%) only after prolonged activity. Ten (77%) were better than before surgery, one (8%) the same and two (15%) were worse. The three patients who were the same or worse had had a delay in diagnosis of over 12 months.
Patients with talar OCL often have persistent ankle pain which remains undiagnosed. Early diagnosis and treatment offers the best chance for a good outcome.
Cigarette smoking prior to and following foot surgery is well recognised as resulting in a higher complication rate. The purpose of this study was to determine the effectiveness of pre-operative counselling prior to elective hallux valgus surgery.
A prospective record of smoking histories was taken in all patients prior to surgery. They were counselled as to the increased complication rate and advised to stop prior to surgery and in the immediate peri-operative period. The mechanism of the increased complication rate was explained to improve their understanding to stop smoking. They were advised to see their GP for specific strategies and medications. Further smoking history was taken on admission and in review clinics. A telephone survey was then conducted to ascertain their smoking pattern following discharge from follow-up.
Forty-two patients underwent hallux valgus surgery over a 12 month operating period. Ten (23%) were recorded as smokers at the time of initial consultation. Most patients (80%) were unaware of the detrimental effects of smoking following foot surgery. Patient education was effective in providing an impetus to stop or reduce smoking in 6 (60%) patients pre-operatively. One further patient subsequently desisted from smoking following surgery. Only two patients had re-commenced smoking following surgery implying a long term change of behavior. Only one complication of a DVT occurred in a patient who continued to smoke.
This small study has shown the effectiveness of educating our patients in the importance of giving up smoking prior to elective foot surgery.
Of the 27 hips preserved, 14 had chondral ‘carpet’ flaps debrided, 17 underwent recession of the acetabular rim at the site of impingement, 6 had removal of medial osteophytes, 6 had labral and/or bony cysts excised and grafted and 1 underwent an osteochondral graft.
Oxford Hip Score improved from an average 36 (range 17–59) to 23 (12–45) and McCarthy hip score from 43 (9–74) to 62 (36–72) in the preserved hips at an average 15 months following surgery (range 6–33 months).
Implant sizing from theatre records was compared with the post-operative films. The size of the implant on radiograph, the magnification of the exposure and the effect of further magnification was noted. Analysis of the results was by paired student’s t testing incorporating inter-observer error into the test statistic.
In the treatment of complex non-unions or malunions, the use of osteoperiosteal decortication can achieve a union rate of 90%. However there are high complication rates although the complications are usually salvageable. In this series the infection rate in the distal tibial was noted to be especially high with 3 out of the 4 infective complications being in the tibial fractures.
Literature searches are commonly performed by medical professionals when carrying out research and during study of a particular topic. Traditionally this was performed manually in a library using a system called index medicus, developed in the early years of the 20th century, and was an arduous task. Over recent years, this has commonly been performed online using electronic search engines, which has drastically reduced the difficulty and time involved in performing a thorough literature search.
Electronic versions of index medicus began in 1964 and were termed MEDLARS. Medline was developed soon after and for many years available on CD-ROM within libraries. In 1997, PUBMED became free to all online, incorporating Medline. (1) Use of online electronic search engines has increased enormously over recent years. In 1996 7 million searches were performed per annum, increasing to 400 million searches per annum in 2001. (1)
The researcher has the ability online to identify articles dating back to 1966, some 39 years of published research and articles to digest.
We performed a retrospective study of 100 medical professionals in a busy district general hospital in the UK with the purpose of identifying how retrospective many of the searches were.
Results showed only 29% of subjects researched papers more than 15 years old, with 65% of subjects only looking at papers 10 years old or younger.
Our study shows that many researchers are now ignoring articles beyond a certain age, and as a result much important research is being largely ignored and possibly repeated.
We present the case of a 19-year-old woman who sustained a right talar neck fracture when the car in which she was travelling was involved in a high-speed collision. She was a front seat passenger travelling with her feet up on the dashboard, and was injured when the passenger airbag deployed. Front airbags are designed to provide protection from impact injury by having the occupant “fall” into the already-inflated device, and in order to inflate quickly enough they rely on an explosive exothermic reaction. It is postulated that an inflating airbag has similar properties to a blast wave produced by an explosion, and thus if a person is in direct contact with an inflating rather than inflated airbag, they may sustain high energy transfer injuries, not dissimilar to blast wave injuries. Although airbags have undoubtedly lead to safer motoring, it is well known that they can cause serious injury in normal usage, and injuries to the face, neck, chest and abdomen have been well documented. They should not be thought of as entirely benign devices.
It is well recognised that there is a requirement for military surgeons to treat the victims of penetrating trauma while on operations. Casualty templates from recent and past conflicts demonstrate that a high proportion of survivable injuries affect the limbs; expertise in the management of penetrating trauma to the limbs is clearly important. While it is widely agreed that a combined specialities approach to limb injuries is necessary, debate has been ongoing for some time in the UK military as to the most appropriate means to gain the necessary experience for treating the wounds encountered on operations.
This study examines the operational requirement, looking at data and individual cases from Iraq, and considers the relevance of a training placement at The Johannesburg General Hospital, a level 1 trauma centre in South Africa.
Surgeon Lt Cdr Mercer RN is currently a Specialist Registrar in Vascular Surgery at MDHU Portsmouth and Surgeon Lt Cdr Ayers is a Specialist Registrar in Plastic Surgery at Frenchay Hospital in Bristol.
Qualitative data for age, time to Ilizarov treatment, number of surgical procedures and time to union did not differ between the two groups (Student t-test). Those returning to work were more likely to have had a hypertrophic non union (p< .025) and were less likely to be using a walking aid (p< .05). No difference was seen between the groups with regards to segment involved, smoking, NSAID use, associated injuries, previous fixation, length of bone defect, free flap coverage, presence of infection, radiological and functional score.
Open phalangeal and metacarpal fractures of the hand were stabilised using an improvised external fixator. This was in the field hospital in Iraq and on military personnel evacuated to the UK. The fixator was improvised from K-wires and a syringe, both of which are readily available in the field hospital. It is a unilateral frame, sufficiently stable to maintain fracture reduction but not too rigid so as to allow micro-motion for fracture healing. We describe our method and recommend this simple method as a quick and easy form of initial or definitive fracture stabilisation in the hand. In the hostile environment of the field hospital we found this method simple, cost effective and relatively safe.
Histological examination did not show any difference in collagen synthesis or remodelling between the 2 groups and there was no evidence of stimulated wound fibroblasts in the GTN group. There was no difference between the groups in the expression of eNOS or iNOS.
Between 1993 and 1996, 35 Kudo unlinked total elbow replacements were performed in a consecutive series of 33 rheumatoid patients. All patients had radiological changes of Larsen grade IV or grade V and met the diagnostic criteria of the American Rheumatism Association. The indication for surgery was intractable pain leading to loss of function. There were 6 men and 27 women with a mean age of 60 years (37 to 79) at the time of surgery. A total of 23 patients were reviewed at a mean follow up of 12 years (10 to 13). Ten patients (11 replacements) had died from unrelated causes prior to the review period. Function was assessed with regards to activities of daily living with the Mayo Clinic Performance Index and DASH scoring. Seven patients had undergone revision surgery after the index procedure with conversion of the Kudo replacement to a Coonrad-Morrey prosthesis. The mean time to revision was 6 years (1 to 11). The indications for revision were periprosthetic fracture (n=1), infection (n=2) and aseptic loosening (n=5). This review represents the longest follow up of the Kudo implant outside of the design unit and includes a detailed assessment of the failed arthroplasties.
Previous studies have demonstrated the benefits of arthroscopic arthrolysis in relieving pain and improving motion in arthritic elbows, but none have reported the specific functional recovery. This study aims to review the functional outcome and patient satisfaction in a series of patients who underwent arthroscopic elbow arthrolysis for intrinsic stiffness, pain and arthritis not suitable for arthroplasty. Twenty six patients who underwent arthroscopic arthrolysis over a three year period were included. All patients were manual workers or strength athletes. All had pain and stiffness secondary to primary or secondary arthritis, with or without loose bodies. Pre- and post-operative evaluation included the Elbow Functional Assessment score, patient satisfaction and return to work and sports. The mean follow up period was 22 months. Function improved significantly in 87% with overall improvement in the Elbow Functional Assessment score from a preoperative score of 48 to a postoperative score of 84 (p< 0.05). All except three patients returned to their desired level of activity by 3 months postoperatively. Pain improved in 91%, mechanical symptoms in 80%, stiffness in all except one. The arc of elbow movement improved from 106° to 124° with a mean gain in elbow extension of 13°. Mayo elbow performance index also significantly improved postoperatively. Overall, 87% patients were very satisfied with the outcome. We conclude that the arthroscopic arthrolysis improves elbow function and returns patients to their desired level of activity, as well as improving range of motion and pain in patients with intrinsic elbow stiffness and pain.
To date there has been only one published series of elbow arthroplasty in patients with Juvenile Idiopathic arthritis. These patients pose particular problems because of the size and variable shape of the humerus and ulna together with the soft tissue contractures and bony erosion which can sometimes be severe. We have reviewed the results of elbow arthroplasty using the unlinked Kudo 5 and the linked Coonrad-Morrey implants which in our practice have different indications dependent upon bone stock and stability.
The aim of this study was to compare the results of humerus intramedullary nail(IMN) and dynamic compression plate(DCP) for the management of diaphyseal fractures of humerus.
To review indications and outcomes of all Ilizarov arm fixators applied by the two limb reconstruction surgeons. All patients treated with an upper limb Ilizarov frame were identified. Casenotes were reviewed. Demographic data, indications and duration of frames collected. Forty-seven patients had application of an arm frame. Average age 43 (17–81). Tertiary referrals in 72%. Previous surgery in 79%. Mechanism of injury included: 37% RTA, 40% simple falls. Reasons for frame usually multifactorial. Half of fixators applied acutely (< 6 weeks), 17 for non-unions. Two patients had neurological complications from frame surgery. One radial palsy possibly from humeral plate removal. One median palsy due to pressure from wire. Average frame time was 152 days (34–343). Over 80% achieved expected outcome -obtaining good function or fracture union. One patient had an above elbow amputation for persistent infection. Fourteen needed further frame surgery including 5 for frame removal, 3 adjustments and 2 corticotomies for lengthening. Most frames removed in clinic. The Ilizarov technique appears well tolerated and successful despite often infected or deformed tissues. Indications and intended function of arm frames very varied. This technique allows stabilisation (with/without bone loss), treatment of non-unions and lengthening/ bone transport. The Ilizarov technique is valuable for limb salvage/ reconstruction.
Over the last 15 years there have been a series of publications reporting the beneficial effects of elbow arthrolysis, with considerable variation in operative technique and post-operative management.
We report our results and technique of scapulothoracic fusion. 14 fusions were performed in 10 patients between 2001 and 2005. The underlying diagnosis was fascioscapulohumeral dystrophy in 7 patients (11 cases). The diagnosis in the remaining three patients was failure of scapular suspension due to C4/5 tetraplegia, stroke and cerebral palsy. There were five women and five men with an average age of 35.4 years (range 15–75) In each case the medial scapular border was wired to the ribs with the support of a one-third semi-tubular plate and autologous bone graft. We compared pre and post-operative active forward flexion and abduction. Satisfaction with the procedure was also rated. There was no need for single-lung ventilation or a chest drain and there were no significant post-operative complications. There were two cases of non-union. One patient, a heavy smoker, travelled abroad and has been lost to follow-up, the other aged 76 is awaiting revision surgery. The mean range of preoperative active forward flexion and abduction were 71° (range 30–90°) and 58° (range 40–90°) respectively. The mean post-operative values were 96° (90–120°) and 94° (80–120°) respectively. The remaining 8 patients were enthusiastic or satisfied with the result of the operation. This technique was very successful in 12 out of our 14 cases (85.7%) and is to be recommended. However, union may be unpredictable in older patients
To evaluate the results of open reduction in unreduced posterior dislocation of the elbow, done irrespective of the time since injury or age of the patient. Ten such cases in which the dislocation had been unreduced for more than 3 weeks since injury were included. Stiffness of the elbow was the main indication for the operation. Average age of the patient was 34.3 years (range 13 years to 65 years). Average time since injury was 3.9 months (range 2 month to 6 months). 3 patients had associated fractures around the elbow joint. All the patients had non functional elbow motion to perform any activity of daily living. We used speed’s procedure in all cases. At an average follow up of 18.5 months (range from 11 to 28 months), 8 patients achieved functional range of motion for activities of daily living and maintained an average arc of flexion(median) of 100 degrees and an average supination – pronation arc of 139.5 degrees. According to the Mayo Elbow Performance Index 5 patients achieved excellent results, 3 achieved good results and 2 achieved poor results. Complications included 2 cases of pin site infection, 1 case of ulnar neuritis and 1 case of delayed wound healing. We conclude that open reduction can provide painless, stable and functional elbow even in cases which are unreduced up to 6 months after the original injury.
This study identifies variations in presentation and demographics for different forms of shoulder instability. We analysed 1020 unstable shoulders (855 patients) from a previously presented database. Demographic details, direction and aetiology were obtained from medical records. Anterior dislocations comprised 67%, posterior 31% and inferior 2% of all directions of instability and 75 shoulders had multidirectional instability. Structural causes were dominant in anterior instability (traumatic 39% and atraumatic 38%) and muscle patterning in posterior (81%) and inferior (90%) instability. Males accounted for 64% of all patients (73% of all structural patients and 53% of muscle patterning patients. Mean age at presentation was 25 years old (structural patients 28 years and muscle patterning patients 21 years old). There were 690 unilaterally unstable shoulders (57% right- and 43% left-sided); the dominant arm was affected in 58% overall, in 42% of all left-handers and only 33% of left-handers with muscle patterning. Bilateral shoulder instability occurred in 19% of all patients (12% of patients with structural instability and 28% of those with muscle patterning instability). For muscle patterning, the mean age at onset of symptoms was 14 years, and mean length of symptoms before presentation was 8 years. There was a trimodal distribution of age at onset of symptoms corresponding to peaks at 6, 14 and 20 years. In the group with onset of muscle patterning under 10 years old, there was a higher proportion of females (71% vs 47%), laxity (63% vs 29%) and bilaterality (54% vs 42%), and fewer presenting with pain (17% vs 50%). As age at presentation increased, pain increased and joint laxity decreased. Bilaterality did not appear to be associated with gender, the presence of laxity or pain. Muscle patterning instability is associated with a demographic and presentation profile which may help distinguish it from structural forms of instability.
We present the use of dynamic electromyographic analysis (DEMG) in the diagnosis of muscle patterning instability. DEMG’s were requested in 168 of 562 muscle patterning shoulders with suspected subclinical or clinically complex muscle patterning instability. An experienced neurophysiologist (blinded to the clinical findings and direction of instability) inserted dual-wire tungsten electrodes into pectoralis major, latissimus dorsi, infraspinatus and anterior deltoid. Muscle activity was recorded during rest, flexion, abduction, extension, and cross-body adduction. 5 investigations were abandoned. The timing and magnitude of muscle activity was noted and compared to the clinical diagnosis and direction of instability. DEMG identified a total of 204 abnormal muscle patterns in 163 shoulders. The examination was normal in 13 patients (8%). A single muscle was abnormal in 63 shoulders, 2 muscles in 55, 3 muscles in 9, and all 4 muscles in one shoulder. Over-activation of pectoralis major was identified in 58%, and latissimus dorsi in 70%, of shoulders with anterior instability. In posterior instability, latissimus dorsi was overactive in 76%, anterior deltoid in 14% and infraspinatus was under-active in 24%. Pectoralis major and Latissimus dorsi were both overactive in 38% of anterior, 29% of posterior and 38% of multidirectional instability. Abnormal muscle patterns were identified in 52 shoulders with subclinical muscle patterning. A further 98 shoulders had 134 clinically abnormal muscle patterns. These were confirmed by DEMG in 57 cases (sensitivity 43%), and DEMG’s were normal in 77 (specificity 43%). DEMG also identified 65 additional muscles as abnormal in the 98 clinically abnormal shoulders. DEMG performed by an experienced neurophysiologist provides additional information regarding abnormal muscle activation in selected complex or subtle cases of muscle patterning instability in which clinical examination has a low sensitivity and specificity.
The study objective was to assess if the mechanical properties of Polylactic Acid (PLA) bio-absorbable suture anchors vary with temperature? Bio-absorbable suture anchors may offer advantages over metal anchors. However, their performance at body temperature has been questioned in recent literature (Meyer et al). In particular, constant tension at body temperature caused early failure at the anchor eyelet. Using a previously validated mechanical jig, 15 standard locked sliding arthroscopic knots (Duncan Loop + three alternate hitches) were tied by the senior author using PAN-ALOK anchors (DEPUY MITEK, Edinburgh, UK) and ETHIBOND sutures (ETHICON) and placed under a standard constant tensile load reproducing the action of the surgically repaired rotator cuff. All anchors were loaded for at least five days to match previous studies. Eight were incubated at a constant 37°C and six were kept at room temperature. The elongation of the suture knot/anchor construct was assessed by a rheostat within the mechanical jig. Sample unused, room temperature and body temperature anchors were blindly analysed using plane polarized light microscopy with a graticule to assess deformation, concentrating on the eyelet region. Mean elongation of body temperature anchors = 0.461mm (0.159 – 0.952) Mean elongation of room temperature anchors = 0.278mm (0.159 – 0.793) Unpaired t-test: p=0.24 Microscopic analysis of the anchor material showed no difference in structural deformation in the three anchors. Our model suggests no significant increase in elongation at body temperature for this commonly used arthroscopic suture anchor / knot construct. This counters previous work. It gives us confidence to continue to use such devices.
To compare the effect of standard non-offset and offset humeral heads on early glenoid loosening. From 2002–2004 in a prospective study, 12 patients with osteoarthritis and intact rotator cuff had a TSR with an offset humeral head matching normal anatomy. Five tantalum markers were introduced into the scapula and acromion, spaced widely apart; four markers were placed in a pegged glenoid component. RSA radiographs were taken postoperatively, three, six, twelve months. The micromotion of this offset head group was compared with a baseline series of TSRs with standard non offset humeral head implants which had previously been measured over 24 months. At 24 months, the largest segment translation for the offset head group was in the anterior/posterior direction with a mean of 0.24mm, the standard head group mean was 0.61mm, t=1.3,P=0.21. Proximal/distal translation gave means of 0.51mm (standard head) and 0.17mm (offset head), t=1.3,P=0.21. Medial/lateral translation was smallest for the offset group with mean 0.16mm this is less than half the standard group mean 0.57mm and is significant, t=1.4,P=0.19. The largest rotation was anteversion/retroversion with a mean of 1.50 (offset) compared to 4.40 (standard), t=2.3, P=0.04. Varus/valgus tilt differed significantly with means 0.90 (offset) and 2.50 (standard), t=3.8,P=0.001; and finally anterior/posterior tilt had smallest means of 0.70 (offset) and 1.00 (standard), t=1.2,P=0.25. Maximum total point motion was also significantly different at 24 months, means of 0.66mm (offset) compared to 1.65mm (standard), t=2.3,P=0.04. Early migration occurs in both groups of pegged components. A principal component micromotion index illustrates the complexity of micromotion. Offset heads move significantly less than the standard type, the significant differences in MTPM movement and in rotation (varus/valgus tilt) suggest that the offset head may decrease eccentric loading
The study investigated if suprascapular nerve(SSN) rhizolysis could give effective and longlasting pain relief to patients with chronic shoulder pain(massive cuff tears and /or osteoarthritis) some with significant comorbidity, who did not wish for or were unable to withstand surgery. Sixty two patients(12 male, 50 female, mean age 74years) with longstanding moderate to severe shoulder joint pain(massive rotator cuff tears, osteoarthritis, rheumatoid arthritis), who had failed conventional non-operative management and who were unsuitable for further shoulder surgery, were assessed for radiofrequency(RF) rhizolysis to the SSN. Most patients reported significant anaesthetic co-morbidity. All patients had received full orthopaedic or rheumatological assessment with investigations including Xray, ultrasound and MRI scan. Ninety-five percent of patients had undergone a SSN block which had afforded > 50% pain reduction for three to six months. The suprascapular notch was identified with Xray control. The SSN was located with 100 Hz and 2 Hz stimulation of an insulated 50mm needle. Once localised, 5 mls of 2% lignocaine was injected and a radiofrequency thermocoagulation lesion undertaken at 700C for 90 seconds. Eighty-five percent of patients reported> 50% pain relief still present at six months (as reported by VAS score). No serious adverse side effects were reported (pneumothoraces, haematomas, infection, neurological deficits). RF rhizolysis of the SSN may be a useful treatment for the group of patients with chronic shoulder pain for whom surgery is not an option.
The aim of this study was to use motion analysis to study a surgeon’s learning curve for an arthroscopic Bankart repair on a training model in a skills laboratory. Six fellowship trained lower limb surgeons unfamiliar with advanced shoulder arthroscopy performed an arthroscopic Bankart repair on an ALEX shoulder model. Standardised training was given and then an electromagnetic tracking system used to objectively assess hand movements, distance travelled by hands and time taken while the surgeons performed the technique. The arthroscopic repair was repeated three times on four consecutive occasions by each surgeon giving a total of 72 repair episodes. Analysis revealed improvement of all outcome parameters with less hand movements, less distance travelled and less time to complete the task. This study objectively demonstrates a learning curve for arthroscopic Bankart suture in a skills laboratory. It indicates the potential benefits of practicing aspects of arthroscopic techniques in a skills centre on appropriately selected models.
Although few published papers assess the results of revision total shoulder replacement for painful hemi-arthroplasty with a functional rotator cuff, surgical outcome is accepted as being poor. Our experience suggests that results are poor if a well-fixed humeral stem is revised to correct version, and if a non-functional rotator cuff is not alternatively managed. We identified fifteen patients with painful hemi-arthroplasty and a suspected functional rotator cuff that underwent revision total shoulder replacement at Wrightington hospital over a ten year period. The aetiology comprised osteoarthritis (seven), inflammatory arthritis (five), trauma (two) and avascular necrosis (one). The average time interval to revision surgery was 44.5 months. Humeral head size was up-sized in two and down-sized in seven cases at revision surgery. Three cases underwent iliac crest autografting for glenoid deficiency. Four cases underwent humeral stem revision for incorrect version. The average surgical time for primary total shoulder replacement at Wrightington hospital is 80 minutes while the average time for these revision total shoulder replacements was 105 minutes. Four patients had an unsatisfactory outcome according to Neer’s criteria due to an intra-operative greater tuberosity fracture (one), an intra-operative humeral shaft fracture (one) and a non-functional rotator cuff (two), one of which was revised to an extended head prosthesis with good outcome. Surgical time for revision and primary total shoulder replacement did not differ significantly if humeral stem revision or glenoid augmentation was not indicated. Oversized humeral head components may cause pain due to overstuffing the joint and soft tissues. Revision total shoulder replacement for hemi-arthroplasty with incorrect prosthetic version cannot guarantee an improved outcome. Significant glenoid deficiencies can be effectively managed by iliac crest bone grafting at revision total shoulder replacement. Rotator cuff deficient patients should be managed with alternative prostheses.
The NHS Plan (2000) identified the need for change in the way patients are asked to give consent for surgery to make the process more explicit. A new NHS operation consent form was introduced in April 2002 following the Bristol enquiry into deaths associated with Cardiac Surgery.
Shoulder – Arthroscopic Sub-Acromial Decompression, Anterior stabilisation, Rotator Cuff repair, excision lateral end of clavicle and Shoulder Arthroplasty. Elbow – Tennis elbow release, Arthroscopic Debridement, OK Operation and Elbow Replacement We became increasingly aware throughout this exercise that although there were many papers published; collating the relevant evidence based information for patients was either difficult or impossible.
Evidence was therefore been categorised into 4 levels:
National &
International published results Our own results, either published or presented at scientific meetings Our own results as identified in internal audited outcome studies – unpublished Our opinion of the risks or benefits unsupported by any scientific or published evidence.
This study describes the method and results of a new way of stabilising painful unstable sternoclavicular joints using the sternocleidomastoid tendon. Painful instability of the sternoclavicular joint is a rare condition whose cause is either of spontaneous onset in young principally females with generalised joint laxity or of traumatic onset. The direction of instability can be anterior, superior or posterior. Surgical stabilisation is difficult and has principally consisted of using periosteum or subclavius and reefing the joint to the first rib with its attendant risks and variable results. We describe eight cases of painful sternoclavicular joint instability treated by using the sternocleidomastoid tendon and passing it through the medial clavicle and onto the manubrium of the sternum to stabilise the joint. This method of treatment is simpler, is reproducible and avoids the potential risks of reefing the joint to the first rib. There is no decrease in function of the sternocleidomastoid muscle from this procedure. All directions of instability can be treated using this tendon by varying the position of the bone hole. The results show comparable outcome for stability with other studies. We conclude that using the sternocleidomastoid tendon to stabilise the sternoclavicular joint is a simpler and safer method of treating these injuries and gives comparable results to the other methods of surgical stabilisation.
A prospective study was carried out to determine if recognised histological features seen at surgery could help predict those rotator cuff tendon repairs which re-ruptured. 40 rotator cuff tendon edge specimens from 40 patients’ shoulders were analysed histologically following routine mini-open rotator cuff repair. 32/40 underwent Ultrasonography, at a mean time of 35 months post-operatively, to determine repair integrity. The histological features seen at surgery were then compared to the repair integrity of the tendon from which it had been taken. Rotator cuff repairs that remained intact demonstrated a greater reparative response, in terms of increased fibrobast cellularity, cell proliferation and a thickened synovial membrane, than those repairs which reruptured. Larger tears which remained intact showed a higher degree of vasacularity and a significant inflammatory component than those that re-ruptured. Good tissue quality at the time of surgery allows the repair the best chance of remaining intact despite the size of the lesion. Routine histological analysis of the tissue biopsy, preformed in the post-operatively, can now aid the clinician in terms of early management and repair prognosis.
The purpose of the study was to test the hypothesis that cellular mechanisms of fibroblasts derived from primary frozen shoulder (PFS) exhibit similar activity in terms of contraction, response to cytokine transforming growth factor-beta1 (TGF beta1) and mechanical stimulation similar to that generated by fibroblasts derived from Dupuytren’s disease. Frozen shoulder has been postulated to be Dupuytren’s disease of the shoulder with an association inferred since 1936. Primary explant cultures of fibroblasts from seven patients with PFS and five control patients were obtained using standard tissue culture techniques. Fibroblasts were seeded in 3-D collagen constructs and contraction force generated over 24 hours measured using a culture force monitor (CFM) in real time. Increasing concentrations of TGF-beta1 were added to cell seeded gels and force generated measured using the CFM over 24 hours. These mechanical output data were statistically compared to data available from Dupuytren’s disease. Compared to Dupuytren’s fibroblasts, PFS fibroblasts showed a statistically reduced ability to contract a 3-D collagen gel over 24 hours (p< 0.01). In Dupuytren’s disease, fibroblasts derived from nodules and cords generate peak forces of 140 dynes and 110 dynes respectively, while PFS fibroblasts generated peak force of 8 dynes The response to TGF-beta1 stimulation, which has been shown to enhance peak force contraction in Dupuytren’s fibroblasts had no effect on PFS fibroblasts and this was statistically significant (p< 0.01). These data suggest intrinsic differences in cellular activity and mechanisms between Dupuytren’s and Primary Frozen Shoulder even though clinically they both manifest with a contracted extracellular matrix affecting function and requiring surgical intervention. This may explain increased post surgical recurrence in Dupuytren’s as compared to Primary Frozen Shoulder release.
The aim of this study was to determine cell viability in different stages of rotator cuff tendon tears using a cell viability molecular probe. Surgical biopsies taken from the edge of the Supraspinatus tendon tear from12 patients, 5 women and 7 men, mean age of 61 years were subjected to a cell viability assay using Molecular Probes Live/Dead cell viability assay. Specimens were then incubated with Calcein-AM and Ethidium Homodimer-1 and following snap freezing, sections were viewed under fluorescent microscopy. Cells which remained metabolically active fluoresced green, whereas dead cells were red. Populations of live and dead cells were counted for each specimen on ten high powered (x400 magnification) fields of view. The results show that the percentage of live cells is reduced in large chronic degenerate tears but greatest in acute traumatic tears. In addition, for those cases where tissue was assayed from the edge of the tear and 1 cm more proximally, there was a considerable increase in the percentage of viable cells in more proximal tissue. Use of this simple assay demonstrates high cell viability and consequently good quality tissue in traumatic tears, but lower quality tissue in larger more degenerate tears. This suggests that traumatic lesions have a high propensity to heal while larger more degenerate tears are less likely to heal but have better quality tissue more proximally.
Complications in internal fixation of proximal humeral fractures can lead to an unsatisfactory outcome. We retrospectively reviewed 22 patients at a mean follow-up of 13 months (range 3–30). The average age was 58 years (36–86) in 10 male and 12 female patients. The mechanism of injury involved a simple fall in 17, MCA in 3, assault in 1 and metastasis in 1. The operation was performed at a mean of 11 days after the injury (range 1–29). There were 12 3-part, 6 2-part, 2 4-part fractures, 1 fracture dislocation and 1 pathological fracture. Only 13 out of 22 patients (59%) did not develop any complications. We had hardware problems in 5 patients including hardware pull-out, plate prominence, screw penetration, loosening or breakage. 2 wound infections, 1 axillary nerve palsy and 1 peri-operative death. 3 patients (14%) had reoperations to remove the plate, 1 had revision fixation, 1 MUA, 1 open capsular release and 1 I+D of wound. Radiographic union was achieved in 18 patients (82%). We identified a relatively high rate of complications especially in alcoholic or unfit patients. Better patient selection and familiarity with the implant and operative technique are essential for a good outcome. Pain relief and union rate were satisfactory.
Cuff Tear Arthropathy is characterised by massive rotator cuff tears, glenohumeral joint destruction and joint effusions containing basic calcium phosphate and calcium pyrophosphate dihydrate crystals. We have investigated the role of the ANKH gene in patients with cuff tear arthropathy and the effect of mutations on protein function. The transmembrane protein ANKH transports inorganic pyrophosphate (PPi) from the intracellular to extracellular space. Control of the extracellular levels of PPi is crucial in preventing calcium crystal formation. Genomic DNA was prepared from peripheral blood leucocytes from 22 patients with cuff tear arthropathy diagnosed clinically and radiologically. All 12 exons and exon-intron boundaries from the ANKH gene were PCR amplified and sequenced with BigDye version 3.1 terminator kit (ABI), and analysed using ABI PRISM ® 3100 Genetic Analyser. ANKH complementary DNA (cDNA) was ligated with mammalian expression vector pcDNA3 and site directed mutagenesis was used to make the ANKH mutation detected in the cases. Human articular chondrocytes were transfected with the cDNA variants and PPi concentrations measured. A G-to-A single nucleotide polymorphism in the 3′ untranslated region (3′UTR) of ANKH was identified. The G/A genotype was seen more frequently in the cases (45%) when compared to controls (20%) (p= 0.0008). We observed altered levels of extracellular PPi in human chondrocytes transfected with ANKH cDNA with the 3′ UTR variant when compared with control cells and normal ANKH cDNA. Cuff Tear Arthropathy appears to be heritable via a G-to-A transition in the 3′UTR of ANKH that alters extracellular PPi concentrations in chondrocyte cells. This supports a hypothesis of a primary crystal mediated arthropathy in patients with Cuff Tear Arthropathy.
Shoulder rotator cuff tears can be very debilitating and painful. Whilst massive tears may defy attempts at surgical repair due to the size of the defect, various biological materials have been proposed to reinforce tenuous repairs; initial results have been promising. It has been suggested that these materials may be used to bridge defects in the rotator cuff as a ‘patch’ or ‘interposition implant’ to provide pain relief and even offer some hope of functional recovery. A porcine dermal collagen implant (Permacol ©) has been engineered and introduced for the repair and reconstruction of soft tissues in the human body. In orthopaedics, it has been successfully used in the reinforcement and augmentation of rotator cuff repairs by suturing it over the repaired tendon. Proper et al reported good short term results in using this implant to bridge defects in massive rotator cuff tears and suggested it was good solution for this group of patients, reporting improvement in all aspects of the Constant Score. We have used Permacol © to reinforce cuff repairs with satisfactory results and thus considered its use as a salvage procedure to bridge massive rotator cuff defects, both of traumatic and degenerate origins. Unfortunately, we have seen with great concern that our results have been less than satisfactory. In a cohort of 20 patients who underwent Permacol © interposition / rotator cuff repair, 4 of these have failed, despite a promising initial recovery phase with good pain relief. We believe that use of this and similar implants to bridge a defect in the cuff is not indicated; MRI and dynamic ultrasound examination showed an inflammatory response in the shoulder, and resulting weakness/failure of the implant. We present clinical, radiographic, and histological findings of our experience and a discussion as to the probable cause for the failure of this implant in this particular group of patients.
There is no non-invasive gold standard for measuring gap formation following rotator cuff repair; re-tears are reported both on MRI and Ultrasound. Roentgen Stereophotogrammetric Analysis (RSA) has previously been used to monitor microscopic migration of markers in rigid bodies. We present a novel RSA technique using a combination of 1mm tantalum beads and metal sutures to allow accurate monitoring of gap formation following rotator cuff repair. The RSA system combines a commercially made calibration cage with software developed at Imperial College. We verified the RSA system by analysing a movable glass phantom and comparing the data with precise physical measurements of the same object: it identified a 2mm distraction of the phantom to within 0.05mm. In vitro work involved cadaveric human shoulders. We placed three 1mm RSA tantalum beads in the greater tuberosity and three metal sutures in supraspinatus tendon. We then created a tear in supraspinatus at its insertion into the greater tuberosity. We were able to show that RSA images taken before and after the tear correlated closely with direct measurements. The processed data demonstrated movement associated with gap formation. We have performed two open rotator cuff repairs using trans-osseous sutures. During surgery RSA markers were inserted into the shoulder to allow post-operative monitoring of the repair (guided by the in vitro work). Direct measurements of the distance between markers each side of the repair were taken intra-operatively (T=O). RSA images were taken immediately post-operatively (T=1 hours), day 3, day 14, and day 84. The RSA data suggests gapping of typically 3mm may have occurred at the repair sites in both patients. Ultrasound imaging was performed at the same intervals by consultant musculoskeletal radiologists blinded to the RSA data. Preliminary results correlating the two modalities suggest that ultrasound can visualise gap formation accurately even immediately post-operatively.
Sub-Acromial Decompression (SAD) for impingement has a failure rate of 5–20%. We used MRI to see whether SAD failure is associated with muscle wasting or fatty degeneration in the rotator cuff. Fifty one patients with impingement were assessed using MRI pre- and post-op. Following arthroscopic SAD, seven patients with cuff tears were excluded. This study reviews the pre-op and 6 month post-op MRIs of the remaining 44 patients (25 males; 19 females) and also 17 additional MRIs obtained at three years post-op. MRI assessment was performed by an experienced radiologist using Zanetti’s muscle bulk assessment with values expressed as standard deviations from an age matched mean and Goutallier’s fatty degeneration assessment graded 0 to 4. There was a wide range of pre-op muscle bulk values (SupraSpinatus minus;2.4 to +3.4; SubScapularis minus;2.1 to +4.8; and InfraSpinatus/ Teres Minor minus;1.1 to +5.7). Comparing post-op with pre-op there was a gradual trend towards a reduced muscle bulk for each muscle after surgery but to a limited extent only (< 0.5SD). Pre-op fatty degeneration of SS and IS was grade 2 in about a half with a mild increase with time post-op (SS pre=50%, 6/12 and 3 years=59%; IS pre=45%, 6/12=43% and 3 years=59%). There was a similar age distribution for grades 1 and 2. Only three of the patients were a clinical failure at 6 months but this increased to five of the 17 patients scanned at 3 years. Predicting these failures was not possible based on the pre-op MRI data. The high initial success of SAD was not accompanied by an overall increase in muscle bulk or quality of the muscle at 6 months. The progressive loss of muscle bulk and quality over 3 years was accompanied by an increased clinical failure rate.
To evaluate the long term functional and the oncological outcomes of patients who underwent scapulectomy as a limb saving procedure for various tumours of the scapula.
A retrospective study was done in twenty-five patients who underwent scapulectomy for various tumours between 1989 and 2005. We describe twenty-three patients of scapular tumours who were followed up for a minimum of two years after surgery. Nineteen patients had malignant neoplasms of which chondrosarcoma was commonest, followed by Ewing’s sarcoma. Surgical staging was done using Enneking’s system; with stage II B being the commonest. Eight patients underwent subtotal scapulectomy of Malawer Type IIA and fifteen patients underwent total scapulectomy (Type III A). All patients with Ewing’s and Osteosarcoma received neoadjuvant chemotherapy.
With a follow-up ranging from 25–202 months, functional prognosis and oncological outcomes were evaluated for all patients. Two patients had superficial wound infections requiring antibiotics and one had skin necrosis requiring skin cover. Three patients died of pulmonary metastasis and the fourth patient died of local recurrence complicated by multiple metastasis. Functional results were analysed using Musculoskeletal Tumour Society scoring system. The Kaplan Meier 5-year survival computed in 19 patients with malignant tumours was 75.9%.
Scapulectomy is a more realistic option for bone and soft tissue tumours around shoulder girdle. It permits a curative, non-ablative, alternative to forequarter amputation in carefully selected patients.
The aim of our study was to assess, for the first time in a large study, whether there are radiological features of the acromioclavicular joint (ACJ) which vary with age or between genders and side. Clinical experience suggested that there was no clear correlation between the radiological features and symptoms arising from the ACJ. Therefore we also aimed to test the null hypothesis that there are no consistent radiological features which correspond with the need for surgical excision of the ACJ. We analysed 240 shoulder radiographs, divided into male and female, left and right shoulders, and decades from 20 to 80 years inclusive. At the ACJ the presence of sclerosis, osteophytes and cysts were recorded, and the width and angle of the joint measured. These same parameters were assessed on the preoperative radiographs for a group of 100 patients by a blinded observer. Fifty had undergone ASD (arthroscopic subacromial decompression), and 50 ASD with ACJ excision. These two groups were age matched. Statistical analyses were performed. There was no statistical difference between any of the parameters for gender or side however with increasing age there was a significantly increased incidence of acromial sclerosis and joint space narrowing. When comparing the matched ASD and the ACJ excision groups it was found that the presence of medial sclerosis of the acromium (p = 0.016) and superior clavicular osteophytes (p = 0.016) were more common in the ACJ excision group. We concluded that there is a change in the radiological features of the ACJ with increasing age but not between sides or gender. The null hypothesis has been rejected. The presence of either medial sclerosis of the acromium, and superior clavicular osteophytes, are radiological features which correlate with a symptomatic acromioclavicular joint.
The deltopectoral approach is a common approach for Shoulder joint replacements where a normal subscapularis tendon is divided. Despite meticulous attention to the subscapular repair, suboptimal return of function was found on clinical examination in 92% of patients (Miller S L: Journal of Shoulder & Elbow Surgery. 12(1): 29–34, February 2003). Therefore the aim was to study the integrity of the Subscapularis tendon in patients with Shoulder joint Replacements both clinical and ultrasound examination
Methods: A cohort of 25 subjects who had undergone Copeland Shoulder replacements through deltopectoral approach were included. All patients had same technique of tendon-to-tendon repair and postoperative rehabilitation. After ethics committee approval subjects were evaluated prospectively with Lift off test, Belly press test and the Constant score. Average follow-up was 29.6 months. An experienced Radiologist performed the Ultrasound examination
Results: Ultrasound examination showed 8 % (2 of 25) had full thickness rupture of subscapularis with 44% (11 of 25) showed mild to moderate atrophy of subscapularis muscle and 12%(3 of 25) severe atrophy. 20%(5 of 25) had Lift off test and Belly press test positive. 40%(10 of 25) had either or both of these tests positive. 60%(15 of 25) had clinical or radiological evidence of reduced function (Fisher exact test, P < 0.01). Constant score are 37.5 with full thickness tears compared to 59.4 with intact subsapularis tendon
Conclusion: Subscapularis tendon function following shoulder replacement had received poor attention. It is deficient in over 60% of patients with joint replacement through Deltopectoral approach with tendon-to-tendon repair. We therefore conclude for this study that alternative techniques of subscapularis tendon repair or alternative approaches to the shoulder joint need to be considered to improve the functional outcome in these patients
Economic evaluation of surgical procedures is necessary in view of emerging, often more expensive newer techniques and the budget constraints in an increasingly cost conscious NHS. The purpose of the study was to compare the cost effectiveness of open cuff repair with arthroscopic repair for moderate size tears. This was a prospective study involving 20 patients. Ten had an arthroscopic repair and 10 had an open procedure. Effectiveness was measured by pre and post-operative Oxford scores. The patients also had Constant scores done. Costs were estimated from the departmental and hospital financial data. Rotator cuff repair was an effective operation in both the groups. At the last follow up there was no statistically significant difference in the patients Oxford and Constant scores between the two methods of repair. There was no significant difference in the time in theatre, inpatient time, post-operative analgesia, number of pre and post-operative outpatient visits, physiotherapy costs and time off work between the two groups. The arthroscopic cuff repair was significantly more expensive than open repair. The incremental cost of each arthroscopic repair was £610 higher than open procedure. This was mainly in the area of direct health-care costs (instrumentation in particular). Health care policy makers are increasingly demanding evidence of cost effectiveness of a procedure. Such data is infrequently available in orthopaedics. To our knowledge there no published cost-utility analysis for the above said two types of interventions for cuff repair. Both methods of repair are effective but in our study open cuff repair is more cost effective and is likely to have better (lower) cost-utility ratio.
To measure any observed migration and rotation of humeral and ulnar components using radiostereometric analysis. From 2002–2004 in a prospective ongoing study, twelve elbows in patients treated with either a linked or unlinked Acclaim total elbow prosthesis were included in a radiostereometry study. Six tantalum markers were introduced into the humerus another three markers were located on a humeral component. Four markers were placed in to ulna and three markers located on the ulnar component. RSA radiographs were taken postoperatively, six, twelve and twenty-four months. The radiographs were digitised and analysed using UmRSA software. The relative movement of the humeral and ulnar implants with respect to the bone was measured. At twelve months, the largest segment translation of the humeral component was in the anterior/posterior direction with a mean of 0.44mm followed by medial/lateral translation of 0.39 mm; there was minimal proximal/ distal translation or with a mean of 0.16mm. Paired t-tests between twelve and 24 months segment translation data showed the mean differences to be no more than 0.056mm. The largest rotation at twelve months was anteversion/retroversion with a mean of 2.40deg, anterior tilt had a mean of 1.20deg and varus/valgus tilt was minimal mean 0.60deg. Mean difference between twelve and 24 months segment rotation was no more than 0.30deg. In contrast, humeral tip motion produced a mean of 1.1mm at 12 months dominated by movement in the plane horizontal plane with a mean difference at 24 months of 0.06mm. No patients could be measured for segment micromotion of the ulnar component due to technical difficulty in visualising tantalum markers in the ulna. Early micromotion of the Acclaim humeral implant occurs mostly by rotation about the vertical axis accompanied by anterior tilt. This motion reaches a plateau at 12 months after operation.
Arthroscopic rotator cuff repair has evolved significantly in the last decade and has become a standard treatment. Satisfactory results of arthroscopic subacromial decompression (ASD) in the treatment of rotator cuff tears have also been reported (
Considerable controversy remains in the literature as to whether hemiarthroplasty or total shoulder arthroplasty (TSA) is the better treatment option for patients with shoulder arthritis. Several cohort studies have compared the outcomes of stemmed hemiarthroplasty with those of stemmed TSA and had inconsistent conclusions as to which procedure is best. However, these studies suggest that stemmed TSA provided better functional outcome. 340 CSRA cases were performed between 1987–2003, 218 Hemiarthroplasty – Humeral Surface Arthroplasty (HSA) and 122 TSA. There was very little difference in the functional outcome and pain in patients with and without a glenoid implant early, as well as, later after surgery. Mean post-operative Constant score for TSA was 85.0% (59.8 points) and for HSA patients 86.8% (62.3 points) with no statistically significant differences (t-test, p=0.4821). A highly significant difference between the overall proportions of revised cases was observed, with (21/122) 17.2% and (6/218) 2.8% of TSA and HSA cases revised, respectively (p< 0.0001). Further, HSA prostheses survive significantly longer than TSA prostheses. The difference between the survival curves was highly significant, both in the earlier post-operative period (Wilcoxon’s test, p=0.0053) as well as the later on (Log-rank test, p=0.0028). Long-term survival of total joint replacement is related to polyethylene wear debris, and therefore its use should be avoided if possible. The difference between our series and those with stemmed prostheses may be due to the fact that with surface replacement the normal anatomy for each patient can be mimicked better than with the stemmed prostheses and there is substantially less place for error as in stem positioning, head sizing or wrong version that may lead to glenoid erosion and less favourable result. Our current practice is and we suggest performing Copeland humeral surface replacement without insertion of glenoid prosthesis.
Between 1997 and 2005, 10 patients with chronic instability of the elbow underwent surgical stabilisation. There were 5 men and 6 women with a mean age of 41 years (16 to 58). All patients had initially dislocated the elbow at a mean of 5.6 years (6 months to 25 years) prior to surgical reconstruction. There were 8 chronic lateral and 2 medial reconstructions performed. The presenting symptoms, findings on clinical examination and methods of surgical reconstruction are defined. Two patients underwent reconstruction using an artificial ligament (Corin) as they had evidence of ligamentous laxity and at the time of assessment all the other patients had been treated using autografts. At a mean follow up of 3 years (1 to 6 years) all patients except one reported no symptoms of pain or instability and had been able to return to their normal work and social activity. The one patient with persisting elbow instability had Ehlers-Danlos syndrome and underwent a second revision procedure again using an artificial ligament (Corin). This review represents our surgical experience and functional outcomes with this rare form of ligamentous elbow injury.
The aim of the study is to assess the humero radial plica which could be a factor in causing lateral elbow pain. The cause of lateral elbow pain has been an enigma for the orthopaedic surgeons over the years. The synovial fold of the humeroradial joint has been well documented and considered as a meniscus between the articulation. They can also present as symptoms suggesting intra articular loose bodies causing pain in these patients. Our study included 117 consecutive elbow arthroscopies performed by two surgeons for a period of 18 months. All patients were initially treated non-operatively as a ‘tennis elbow’ before undergoing arthroscopy. Conservative treatment included rest, activity modification, physiotherapy including ultrasound bracing, nsaids and local corticosteroid injection. All patients were assessed using the Mayo clinic performance index for elbows both pre and post operatively. Radial head plica was found in 21(18%) out of 117 elbow arthroscopies and was resected using a soft tissue resector. There were 16 (76%) men and 5(24%) women in this affected group and all of whom were young and active with a mean age 38 years. Of the 21 patients 16(76%) had a post operative score of 90 or more (excellent) and 5(24%) had a score 75–89(good). This study addresses the fact that cause of lateral elbow pain can be due to various pathologies in the elbow and in the cases of ‘resistant tennis elbows’ we recommend that the existence of a radial head synovial plica should be considered and if present treatment should be directed at this. Our study demonstrates that by resecting the synovial plical fold, pain will be relieved and these patients regained elbow function. Since this was noted in the young active age group this could reduce the morbidity and the time for rehabilitation required especially for those involved in active sports. A similar series has not been cited in English literature
The aim of this study was to observe the macroscopic and microscopic appearance of the Coracoacromial ligament and Subacromial bursa during Subacromial decompression and correlate it with the outcome at 3 months. Twenty patients with Subacromial Impingement without Rotator Cuff tear and five patients with large/massive irreparable Rotator Cuff tears who underwent a Subacromial Decompression. Patients with other shoulder pathology were excluded. Patients completed an Oxford Shoulder Score pre-operatively and their injection history was noted. At operation the shape of the acromion was noted. The macroscopic appearance of the CA ligament and the Subacromial bursa was classified as normal, mild/moderate and severe. Biopsies of the Subacromial bursa and CA ligament were taken and were analysed using histological and contempory immunocytochemical techniques. A histological analysis was performed using Mayer’s Haemotoxylin and Eosin, Toluidine Blue and Congo Red. Sections were stained with primary antibodies against PCNA (Proliferating cell nuclear antigen), Mast Cell Tryptase, CD3 (T-cell), CD20 (B cell), CD 34 (QBEnd 10), CD45 (Leucocyte Common Antigen), CD68 and D2–40 (Lymphatic Endothelial Marker). Post operatively the patients completed an Oxford Shoulder Score at 3 months. All the patients demonstrated an improvement in their Oxford Shoulder Score. The histological analysis demonstrated thickening of the synovial membrane and increased vascularity within the bursa and ligament. Increased numbers of inflammatory cells were present within the ligament and bursa of patients with impingement compared with massive rotator cuff tears. There was a relationship between outcome and the appearance of the bursa and ligament.
Percutaneous fixation is a well recognised technique in the treatment of three-part and four-part fractures of the proximal humerus. Minimal fixation of these fractures do show good functional outcome and may further reduce the incidence of avascular complications. We report a preliminary series of 11 patients who underwent percutaneous minimal fixation of such complex humeral fractures using a new technique. 11 consecutive patients (7 with three-part fractures and 4 with four-part fractures) treated by percutaneous limited fixation in our Hospital were involved in this retrospective study. There were 7 fractures with valgus displacement. Percutaneous technique was employed using small incisions and the fracture was reduced under image guidance. The three-part and the four-part fractures were essentially converted into two part fractures, i.e. only the greater and the lesser tuberosities were re-attached to head with AO cancellous screws after realignment of the fragments. The shaft of the humerus was not fixed to the head in any of the cases. All of these cases had a minimum follow-up of at least 6 months. The results were evaluated using the Constant -Murley Shoulder score. 1 out of 11 cases had to be converted to hemi-arthroplasty due to secondary redisplacement of the fracture. The remaining 10 cases showed good bony union although the greater tuberosity in 2 cases showed a residual superior displacement of 3mm and a residual valgus displacement in 2 out of 7 cases. There were no complications of avascular necrosis in any of the cases. Clinically, compared to the uninjured side the average constant score was 93.7% (range- 68.7% – 100%). 7 patients were very satisfied and 4 were satisfied with the operation. Percutaneous minimal fixation achieves good to very good functional outcome comparable to the conventional methods and theoretically reduces the incidence of infection, avascular necrosis and neurological complications.
There is concern that intra-articular electrosurgical ablation may cause thermal soft tissue damage, particularly chondrolysis, if excessive temperatures are reached. The aim of this study was to determine whether the intra-articular temperature during arthroscopic subacromial decompression using a monopolar electrosurgical ablator remains below a safe level. Data was collected prospectively from consecutive shoulder arthroscopic subacromial decompressions performed at our institution. Shoulder arthroscopy was performed using three standard portals. Evaluation of the glenohumeral joint and subacromial space was performed in a standard manner. Soft tissue resection of the subacromial bursa was performed using a monopolar electrosurgical ablator probe with continuous integral suction. Additional procedures such as acromioclavicular joint excision and rotator cuff debridement or repair were performed as appropriate. Bone resection, if required was performed using an arthroscopic burr. The temperature of the fluid within the shoulder and subacromial space was continuously monitored using a sterile digital temperature probe. The surgeon performing the procedure was blinded the collection of data. Data from thirty subacromial decompressions has been collected. 8 patients had full thickness cuff tears of which 6 were debrided, and 2 repaired arthroscopically. 13 patients had acromioclavicular joint excision. Mean operating time was 46 minutes (30–107). The infusion pressure ranged from 40 to 65 mmHg. The median volume of infused fluid was 3900 ml (1500 to 9000). The starting temperature ranged from 18.3 to 21.9. The mean maximum temperature reached was 27.6 (range 22.7 to 41.8 °C). The results suggest that the intra-articular temperature is maintained within safe levels when a monopolar electrosurgical ablator with integral suction is used to perform soft tissue subacromial decompression.
To identify the incidence and timing of superior subluxation following total shoulder replacement (TSR) and any associated change in pain, activities of daily living and ranges of movement. Forty-six TSR in rheumatoid patients with more than 5years follow-up were identified from a prospectively compiled database held by the senior author (ANS). Modified Constant scores (excluding the power component) were measured and recorded prospectively every 2years. Pre-operative and complete follow-up scores were available for 35 joints (27 patients). A Mann-Whitney U test was used to compare patients with subluxation and those without, with regard to the changes in the components of the Constant score at last follow-up compared with the pre-operative score. Superior subluxation of the humeral head was defined as when the lower third of the humeral head had migrated level or superior to the midpoint of the glenoid component as measured on the AP radiograph. An independent observer reviewed AP radiographs, taken at each 2 yearly review, at random with identity hidden and in no particular date order. Twenty-three patients developed superior subluxation since surgery, of which 87% occurred after 5years. Of the 35 joints with both clinical and radiological follow-up, 16 had evidence of subluxation. There was no statistically significant difference between the changes in the activities of daily living (Mann-Whitney U=106, p=0.1) and range of movement (U=140, p=0.7) components of the Constant score. However, patients without subluxation had a greater improvement in their pain scores (U=80, p=0.02). Approximately half of rheumatoid patients with TSR will demonstrate radiological changes of superior subluxation, in the majority after 5 years. This change is not associated with deterioration in activities of daily living or ranges of movement. However, pain relief persists irrespective of subluxation but is better maintained in those without subluxation.
Assesment at teaching courses has been restricted to subjective assessment by questionnaire of the quality of teaching sessions and the teachers. This does not give any information on the extent of learning by the participants. Formal skills assessment during a practical course can be complex, time consuming and may distract from the teaching process. The purpose of the study was to quantify learning at a skills course on open shoulder surgery using a knowledge based questionnaire before and after completion of the course.
We evaluated the long-term benefits of steroid injection in 20 consecutive patients (25 shoulders) with primary acromioclavicular arthritis using the Constant score. All patients were followed up for a minimum of 5 years. The average age of the patients was 55 years. The mean pre-injection Constant score was 61 points. At six months this improved to 81 points, (mean difference – 19.36) which was highly statistically significant (p< 0.01). There was further improvement at 12 months, on the 6-month score, mean 86 points that also showed a significant improvement on the 6-month score (p = 0.001). At 5 years the mean score was 81 points and this was a significant detoriation compared with the 12-month score (p=0.01) but still a significant improvement when compared to the preinjection scores (p< 0.0005). In addition, the younger the patients, the greater the improvement in the objective score which measures range of movement and power (r= − 0.47; p= 0.01). Female patients also had a greater improvement (r=0.405; p=0.05). We conclude that local steroid injection is an effective method of treatment for primary isolated acromioclavicular arthritis and improvement continues for at least 12 months and the benefit is felt up to 5 years though the pain relief tends to tail off long-term.
Given that there is limited time available to the surgeon in arthroscopic rotator cuff repair, how is the time best spent? Should he place one Modified Mason-Allen, two mattress or four simple sutures? This study reverses current thought. In an in-vitro biomechanical single pull to failure study we compared the ultimate tensile strength of simple, mattress and grasping sutures passed with an arthroscopic suture passer (Surgical Solutions Express-Sew). The aim was to determine which suture configurations would most simply, repeatably and reliably repair the rotator cuff. The ultimate tensile strength and mode of failure of six different suture configurations was repeatedly tested on a validated porcine rotator cuff tendon model, using a standard suture material (Number 2 Fiberwire) passed with the Surgical Solutions Express-sew, in a Hounsfield type H20K-W digital tensometer. Standardising the number of suture passes to four, the strongest construct was two mattress sutures (Mean 169N), followed by single Modified Kessler (Mean 161N), four simple sutures (Mean 155N) and finally a single Mason Allen suture (Mean 140N). Suture configurations involving two passes were all weaker than those with four (one way analysis of variance p=0.026), even when Number 2 Fibertape was used to augment strength. These results show little difference in strength for varying complexity of four pass suture passage (one way analysis of variance p=0.61). In simple terms there is no demonstrable difference in the strength of construct whether the surgeon uses four simple, two mattress or one grasping suture. This study allows the surgeon to justify using the simplest configuration of suture passage that works in his hands in order to obtain a reliable and repeatable repair of the rotator cuff arthroscopically.
We have reviewed the management and outcome of ununited fractures of the humerus in a specialist limb reconstruction unit. A retrospective study conducted at Kings College Hospital, including referrals during the period September 1994 to present. There were 47 cases of humeral non-union, (14 proximal, 25 diaphyseal and eight distal). The time of referral from injury ranged from two months to eight years, with one patient referred after 37 years. 38 of the 47 patients had undergone an average of 1.08 operations prior to referral. Treatment aimed to achieve alignment, stability and stimulation. Methods were as follows: Proximal fractures [14]: nine Locked Compression Plate (LCP), five Dynamic Compression Plate (DCP). Autologous bone graft alone [eight], Bone Morphogenic Protein (BMP – Osigraft) alone [three], both bone graft and BMP [three]. 13 have united. One is under treatment. Mean time to union was six months. Diaphyseal fractures [25]: 12 LCP, four DCP, five Intramedullary (IM) nail, one Ilizarov frame and one required observation only. Autologous bone graft alone [17], BMP alone [two], both bone graft and BMP [three]. 23 have united. One patient awaits surgery. One patient declined surgery. Mean time to union was four months. Distal fractures [eight]: four LCP, two DCP, two Ilizarov frames. Autologous bone graft alone [seven], both bone graft and BMP [one]. Seven have united. One is under treatment. Mean time to union was seven months. Open reduction and appropriate stabilisation, together with the stimulus of autologus bone graft and/or BMP consistently resulted in healing of ununited fracture of the humerus. Many treatment methods were employed. It is not clear whether it was the treatment method or the accumulated experience of the Limb Reconstruction Unit, which was responsible for a high success rate comparable to, or better than, published results.
We present an all arthroscopic technique for modified Weaver Dunn reconstruction of symptomatic chronic type III ACJ joint injuries. Over a one year period we performed 12 all arthroscopic modified Weaver-Dunn procedures. All patients had failed non-operative management for at least 6 months. The technique involved excision of the lateral end of clavicle, stabilisation with a suture cerclage technique from 2 anchors placed in the base of the coracoid and coracoacromial ligament transfer from the acromion to lateral end of clavicle. Post-operatively the patients were immobilised for six weeks, followed by an active rehabilitation programme and return to work and sports at 3 months. We have currently performed this technique in 12 patients, all male. The average age at operation was 25.8yrs at a mean interval of 11 months post injury. The mean Constant score preoperatively was 49 (44–54). The mean 3 month postoperative Constant score was 88.6 (84–96). There have been no complications, and the 2 professional sportsmen within our cohort returned to full contact at 3 months. Due to an irreducible clavicle, one patient required an open excision of lateral clavicle, with the rest of the procedure performed arthroscopically. Arthroscopic Weaver-Dunn has a number of advantages over the corresponding open procedure. It avoids the detachment of deltoid needed to gain exposure and also the morbidity from the wound. From our experience is that it enables patients to regain their function more rapidly with an earlier return to sporting activities. The early results from our initial experience have been excellent, with no complications. With this technique an anatomic reconstruction can be achieved with excellent cosmesis, low morbidity and potentially accelerated rehabilitation.
Many different clinical examinations are used to assess instability of the glenohumeral joint. Validation of these includes clinical data, follow-up, imaging, and arthroscopy. In spite of these many works, there currently exists no clear unique method for identifying and validation novel clinical examinations. The aim of this study was to use a computational tool to quantify the specificity of clinical examinations in assessing glenohumeral ligament (GHL) pathology. Five GHLs were modelled according to the literature [
The aim of the study is to compare the postoperative pain relief provided by continuous perfusion of wound by bupivacaine and fentanyl with that of patient controlled analgesia using morphine in elective shoulder surgery. This retrospective case control study included 76 consecutive patients who had elective shoulder surgery. 39 patients had patient controlled analgesic system (PCA) with morphine and 37 patients had a continuous wound perfusion with bupivacaine and fentanyl via a disposable Silicone Balloon Infuser. Patients were also given additional oral NSAIDs or morphine if needed. The pain score measured postoperatively based on a 10 point Visual Analogue Scale (VAS) at 1, 2, 3 and 18 hours was noted. The use of antiemetics and additional painkillers was recorded. The complications of both methods were also noted. We found that the analgesia provided by continuous perfusion of wound by bupivacaine and fentanyl was constant and comparable to that provided by the patient controlled analgesic system using morphine. PCA with morphine was associated with significantly high incidence of nausea and vomiting (p < 0.001). We conclude that continuous perfusion of the wound by bupivacaine and fentanyl appears to be a simple, effective and safe method of providing analgesia following elective shoulder surgery.
To evaluate a peri-operative protocol developed to facilitate day case open shoulder procedures that historically have required overnight hospital admission. 75 consecutive day-case open shoulder procedures were performed in 75 patients (aged 18 – 65) followed up prospectively for a minimum of 6 months. The procedures included Open Primary Anterior Capsulo-Labral Reconstruction (ACLR) (24), open Revision ACLR (4), open Posterior Capsulo-Labral Reconstruction (2), mini-arthrotomy and rotator cuff repair (6), mini-arthrotomy and sub-acromial decompression (28), modified Weaver Dunn Reconstruction of Acromio-clavicular joint (ACJ) (2), decompression of ACJ (7), open release for frozen shoulder (2). Exclusion criteria included concomitant medical problems, and patients who would have no assistance in their care for the first 24 post operative hours. All patients received general anaesthesia, peri-operative analgesia using intravenous Fentanyl, and Diclofenac (PR), and local Bupivicaine 0.5% to incisions and intra-articular spaces; patients were discharged with oral analgesics. Patient satisfaction with overall experience, pain control, the incidence of nausea that was difficult to manage, the incidence of unplanned admission, attendance or delayed admission to hospital and postoperative complications were measured. 98% of patients were satisfied with their pain management. None of the patients suffered intractable post operative pain, nausea or vomiting; none required unplanned hospital admission or unexpected re-admission. All the patients were satisfied with their overall experience. There were no short or long term post operative complications. In conclusion, the anaesthetic protocol and surgical techniques used in this study permitted same day discharge for a wide variety of open shoulder procedures. For selected patients, open shoulder surgery as a day case appears to be safe effective and acceptable to the patient.
The use of high resolution ultrasonography for the detection of rotator cuff tears has achieved only limited acceptance by orthopaedic surgeons. Uncertainty about the accuracy of ultrasonography may be a contributing factor. The purpose of this study was to evaluate the accuracy of high-resolution ultrasonography compared to shoulder arthroscopy in the detection of rotator cuff tears. 100 consecutive patients with shoulder pain in whom arthroscopic surgery was planned underwent standardized preoperative ultrasonography. The ultrasound examinations were done by a single experienced musculoskeletal radiologist using a standard protocol. The findings at ultrasound were classified into intact cuff, tendinopathy, partial-thickness tear, and full-thickness rotator cuff tears. The size of the tear was measured in centimetres. The location was designated as subscapularis, supraspinatus, infraspinatus, or a combination. All of the subsequent shoulder arthroscopies were done by a single surgeon. The presence or absence of a rotator cuff tear and the size and extent of the tear when present were recorded. We then compared the ultrasonographic findings with the definitive operative findings. For the detection of rotator cuff tears, ultrasound had a sensitivity of 95% and a specificity of 94%; accuracy 95%. There was 100% sensitivity for full thickness tears (specificity 91% and accuracy 95%), while for partial-thickness tears there was a sensitivity of 80%, (specificity 98% and accuracy 95%). In experienced hands, ultrasound is a highly accurate diagnostic method for detecting rotator cuff tears. The results of this study compare favourably with the published results of magnetic resonance imaging for the investigation of this condition. Furthermore, dynamic imaging and comparison with the opposite shoulder is possible with ultrasonography.
Assess the outcome of plating of lateral end clavicle fractures. Lateral end clavicle fractures can be treated both conservatively and surgically. Different surgical methods are available to stabilize lateral end clavicle fractures. We treated 15 lateral end clavicle fractures with plate fixations (4 AO ‘T’ plate and 11 ACUMED lateral clavicle plate) from September 2002 to December 2005. There were 12 males and 3 females and the mean age was 33.12 year (range 23–61). 3 were done for non-union and 13 for acute fractures. 2 non-unions were treated with AO ‘T’ plate and 1 with ACUMED lateral clavicle plate. 1 patient with non-union had bone grafting at the time of the procedure. Acute fractures were stabilized with in 3 weeks from the time of the injury. All fractures were Type 2 according to Neer classification of lateral end clavicle fractures. The cause of the injury was, simple fall (3), fall from pushbike (3), assault (3), sports/skate-board (3), and RTA (3). The senior author operated on all patients. The arm was immobilized in a sling for six weeks post operatively. The follow up ranged between 5 months to 36 months All but one fracture healed. 1 ‘T’ and 1 ACUMED plate was removed 7 months after the index procedure after fracture consolidation. There was no superficial or deep infection. Patients were assessed clinically with Constant and DASH scores; patient satisfaction with the procedure was also recorded and union assessed radiologically.. Lateral end clavicle fractures pose a challenge due to the small size of the distal fragment. In our experience plating of these fractures give satisfactory results. Oblique fracture patterns result in better fixation and union rates. The plate design and advantages of the ACUMED contoured distal clavicle plates are further discussed in the paper.
We aimed to test the biomechanically predicted hypothesis that in massive rotator cuff tears irreparable by conventional methods the newly developed Nottingham Augmentation Device (NAD) would provide greater functional improvement than that gained from the gold standard of arthroscopic subacromial decompression. Thirty patients treated between 2001 and 2004 were assessed by pre- and six month post-operative Constant scoring. Fifteen underwent open acromioplasty and cuff reconstruction using the NAD (mean age 67.3), while 15 underwent a standard arthroscopic decompression (mean age 67.4). The two groups were matched retrospectively based on size of cuff tear, age and sex. Data was analysed using the student’s t-test at the 95% confidence interval. Both groups displayed a statistically significant increase in Constant score after surgery. The mean increase for NAD patients was 18.7 points compared with 17.6 points for those undergoing arthroscopic decompression. However there was no significant difference between the two groups’ improvement and this was even so in the power sub-category, where increased benefit was predicted with the NAD. The NAD requires greater surgical access, operating time and peri-operative analgesia, and no active mobilisation for six weeks. The arthroscopic technique is minimal access, rapid, involves no prosthesis or foreign body insertion and allows immediate mobilisation. However, with clear biomechanical benefits of the NAD seen in vitro, our results may simply reflect cuff tears in an older population group with irreversible tissue changes and less rehabilitative potential. A randomised prospective trial in a younger patient group with more acute tears and less tissue atrophy would appear the next step in determining the NAD’s place in the management of massive rotator cuff tears.
We undertook this study to evaluate our results of Arthroscopic Capsular Shrinkage as a treatment of Multi Directional Instability of the shoulder. Patients with symptomatic multidirectional instability (MDI) have excess capsular laxity. Arthroscopic capsular shrinkage is a fairly new procedure, to treat laxity with variable results in the reported literature. We analysed the records of patients who under went 20 (10 males, nine females) arthroscopic thermal capsular shrinkage procedures for MDI of the shoulder, which were performed by the senior author between 2000 and 2004. The mean age was 28.3 years (median 29.4, range 18 to 46 years) and the mean follow up was 44.5 months (median 43, range 20 to 69 months). All patients had undergone specialist shoulder physiotherapy for four months or more prior to surgery. The type of shoulder instability was subcategorised (based upon the predominant symptomatology as perceived by the patient) as follows: dislocation (seven), subluxation +/− pain (nine), and impingement (four). The procedure and postoperative regimen were standardised. Clinical outcome measures were: patient satisfaction, pain and instability. Sixteen shoulders (80%) were symptom free and fully satisfied at last follow up. One patient (5%) had some pain but a stable shoulder. Three patients (15%) [two dislocators and one subluxator] had recurrent instability between six to eight months post operatively and underwent further surgery. The less the instability, the more likely it was, that the procedure would succeed. We conclude that out results are encouraging particularly in patients with less severe instability despite the small size (20) of our cohort of patients. We think that careful patient selection may be important for success from this surgery.
Introduction The value of collecting continuous prospective patient data, including operation records and outcome scores, is well known. In 1994, a systematic prospective patient data collection was initiated on all patients attending the Reading Shoulder Unit (RSU). Initially this was done with hand written records. In 1995 a Windows Access ® database was formulated on a portable laptop. This was used continuously through until September 2005 when an Internet web-based database was introduced. We present this collective data and trends in practice from a busy shoulder unit over this decade. Results Between 1995 and 2005, 10005 entries were made to the Reading Shoulder Unit database. 3233 patient visits to outpatient clinics were recorded. 6772 operations were recorded – this includes: arthroscopic decompressions (ASD) + AC joint excisions − 3514, MUA for frozen shoulder 842, shoulder arthroplasty 432, open stabilisation 356, arthroscopic stabilisation 192, arthroscopic rotator cuff repair (RCR) 402, open cuff repair 290, arthroscopic capsular release 78 and 248 trauma cases. Changes in the unit practice include the move from open to arthroscopic reconstructive surgery (RC and stabilisation), RCR rather than ASD alone in elderly patients with impingement and cuff weakness, and repairing partial rotator cuff tears when previously we did not. Conclusions With over 10000 continuous and prospective entries – the RSU database is invaluable for continuous audit of practice and assessment of outcomes of the different procedures. Several practices have changed through the decade; most notably from predominately open reconstructive surgery through to arthroscopic reconstructive surgery. We would recommend to every surgeon and unit to collect his own data prospectively to enable him to analyse and assess his results.
There is debate regarding the most appropriate treatment of calcific tendinitis. Minimally-invasive techniques with image-guided needling of the deposits have been developed to provide an alternative solution. We present the results of fluoroscopically-guided barbotage in 100 patients. One hundred patients with acute or chronic shoulder pain, visible on plane radiographs or ultrasound scan, were referred from the Orthopaedic Department for barbotage over a six-year period. This study is a retrospective review of the results of barbotage in these patients, using a patient-based questionnaire. Forty three patients ultimately required arthroscopy of their painful shoulder. However, at surgery, the calcific deposits were noted to have dispersed in the majority of these patients. In addition there was often a long symptom-free period between the initial barbotage and recurrence of pain. In many cases the nature of their symptoms had changed and at arthroscopy signs of impingement or rotator cuff tears were common. Barbotage eliminated the need for more invasive surgery in over half of the patients in this study. It should be considered in all patients with calcific tendinitis refractory to non-operative treatment.
To identify mechanisms of failure in plate and nail fixation in proximal humerus fractures. 5% of the proximal humerus fractures need surgical fixation, which is carried out, principally, by open reduction and internal fixation or closed reduction and intramedullary nailing. Fixation failure remains a problem. This study answers the mode of failure of these implants regardless of the fracture personality. In-vitro testing of proximal humerus fixation devices was undertaken in 30 simulated osteoporotic bone models. Fracture-line was created at the surgical neck of humerus in all samples and fixed with five fixation devices; three plating and two nailing devices. The samples were subjected to failure under compression and torque. Failure was achieved in all models. Three failure patterns were observed in torque testing:
The two conventional plates Cloverleaf and T-plate behaved similarly, failing due to screw pull-out from both the proximal and distal fragment with a deformed plate. The PHILOS plate failed by avulsion of a wedge just distal to the fracture site with screws remaining embedded in the bone. Both the nailing systems, Polaris and European humeral nail, failed by a spiral fracture starting at the distal locking screw. In compression testing the modes of failure were: The Clover-leaf and T-plate failed by plastic deformation of plate, backing out of the screw in the proximal fragment followed by fracture of the distal fragment. The PHILOS failed by plastic deformation of plate and fracture of the distal fragment distal to the last locking screws. In both the nails, the proximal fragment screws failed.
The failure mode is dependent on implant properties as well, independent of the fracture personality. It is important to recognise the potential points of failure (proximal or distal fragment) when making the choice of implant to avoid fixation failure.
The aim of this work was to define the tensile material properties of the glenoid labrum. Previous SEM studies of the labrum have observed three definitive layers, with a densely packed circumferentially orientated collagen core layer. The glenoid labrum from ten cadaveric shoulders were dissected out and divided into eight equal sections. Each section was cut to produce specimens from the core layer using a microtome and a specifically designed cryo-clamp resulting in uniform specimens with dimensions of 1mm x 1mm x 8mm. All of the tensile testing was performed within a controlled-environment unit of 38°C and 100% relative humidity. Each specimen was precycled to a quasi-static state to alleviate the effects of deep-freezing, prior to final testing. The elastic modulus was calculated for each specimen before and after a 5-minute period of stress relaxation and before failure initiation. The mean age of the specimens was 61 years (range 47–70). Load to failure was 2.7N (1.0–7.0). The mean modulus was 10.2MPa (3.0–22.3) before stress relaxation, 18.0MPa (5.8–36.7) immediately after stress relaxation and 22.3MPa (8.4–66.4) before failure initiation. The 1 and 2 o’clock specimens had lower moduli than the 4 and 5 o’clock specimens (p=0.01). These results can aid in explaining the differing pathologies encountered around the circumference of the labrum. The high moduli at the 4 and 5 o’clock positions may reflect the ability of this portion of the labrum to accommodate forces and thus resist anteroinferior subluxation. The lower moduli at the 1 and 2 o’clock positions suggest that this portion of the labrum is less apt to accommodate tension; this might explain the higher incidence of labral foramen observed in this area and the anatomical variant of the Buford complex.
Clinical examination. Constant Scoring. Cybex testing of the rotator cuff muscles. MRI scans. Arthroscopic examination followed by arthroscopic SAD. Standard post-op rehab.
Tests were repeated at 6 months, and in 17 patients again 3 years after surgery.
SAD still provides good pain relief Muscle power increases post-operative but tends to plateau or slightly decrease after 3 years Dynamic muscle power measurement is recommended for accurate assessment. Other Cybex measurements (Torque) had little relation to clinical outcome. Constant score does not accurately assess changes in muscle power.
The aim of this study was to review the results of surgery on patients who had recurrent instabilty of the shoulder associated with significant bone loss who were treated by autogenous iliac crest tricortical grafts. Ten consecutive patients were reviewed. All had significant loss of glenoid bone stock as assessed by CT scan. All were treated by use of tricortical bone graft harvested from the iliac crest and fashioned to reconstitute the anterior glenoid defect. This was fixed intra-articularly with cannulated screws. The antero-inferior capsule was then repaired to this new “glenoid rim”. All patients had a standard rehabilitation regime. All patients had an assessment of the Oxford Shoulder Instability Score (OIS) and the American Shoulder and Elbow Surgeons Score (ASES) before and after the operation. At an average follow-up of 26 months, the mean OIS had improved from 38.3 to 22.3 and the mean ASES had increased from 40.5 to 86.6. None had had a recurrent dislocation. The use of autogenous iliac crest bone graft to treat recurrent shoulder instability associated with significant glenoid bone loss is an effective treatment for this difficult condition.
Immediate and more accurate diagnosis and plan accordingly. Avoid unnecessary or inappropriate treatment while waiting for radiological test. High patient satisfaction. Reduce waiting time for definitive treatment. Reduce number of patients’ visits. Improve and advance clinical and radiological skills. Reduce the cost to the NHS. Promote a multi-disciplinary approach to patient healthcare.
We report 5 cases of linked shoulder and elbow replacement (LSER) following failure of single-joint arthroplasty. Whilst total humeral replacement has been reported for treatment following resection for tumour we know of no reports of linked shoulder and elbow prostheses for arthropathy alone. Between May and December 2005, 2 patients with total elbow arthroplasty and 3 patients with total shoulder arthroplasty were revised to LSER for loosening of the long humeral stems or periprosthetic fracture. Custom-made prostheses were produced using computer-aided design and manufacture technology. There were no early complications including infection. All 5 patients reported early improvement of symptoms, with the ability to bear weight axially through the limb, restored. This technique avoids the problem of a stress riser between the stems of separate shoulder and elbow replacements and solves the problem of salvage of long-stemmed implants where no further humeral fixation is possible.
Introduction and aims: There is a recent trend of using a raft of small diameter 3.5 mm cortical screws instead of the large diameter 6.5mm screws in depressed tibial plateau fractures (Schatzker type 3). Our aim was to compare the biomechanical properties of these two constructs in the normal and osteoporotic sawbone model.
The models were loaded to failure using a Lloyd’s machine. A displacement (depression) of 5mm was taken to be the point of failure. A load displacement curve was plotted using Nexygen software and the force needed to cause a depression of 5mm was calculated in each block. Mann Whitney U test was used for statistical analysis.
The mean force needed to produce a depression of 5mm was 700.8N with the 4-screw construct and 512.4N with the 2 screw construct. This difference was statistically significant (p=0.007).
Non-osteoporotic model
The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct. The difference was not statistically significant (p=0.42).
An increased fragmentation of the sawbone fragments was noticed with the 2-screw construct but not with the 4-screw construct.
Mesenchymal stem cells (MSCs) are immunosuppressive and have been used to facilitate tissue repair in the context of allogeneic implantation. However, xenogeneic cell transplantation has not been fully explored. The present study investigated the feasibility of xenogeneic MSCs implantation in mice.
MSCs were harvested from the bone marrow of GFP rats (Green Fluorescent Protein transgenic rats), and cultured as previously described. 1 million GFP MSCs were loaded onto the synthetic HA/TCP porous Skelite blocks and implanted intramuscularly into the quadriceps of the MF1 and SCID mice. After 11 weeks, the implants were harvested and processed for histology examination. Upon termination, the mononuclear cells from the peripheral blood of each animal were also collected for mixed lymphocyte culture to examine lymphocyte proliferation potential and T-cell mediated cell lysis (cytotoxic) assays.
In the SCID mice, there was sparse osteoid tissue formation in the implants, whereas only dense connective tissues were seen in the implants of the MF1 mice. Osteocalcin mRNA expression was confirmed in the osteoid tissues in the implants from the SCID mice, but it was not detected in the MF1 mice by RT in situ PCR examination. Cells of GFP-rat origin were observed in both the MF1 and SCID mice (more so in the SCID mice) after 11 weeks implantation, which were confirmed by positive immunostaining of anti-GFP antibody. In the MF1 mice after 11 weeks xenogeneic MSCs implantation, the rate of lymphocyte proliferation was significantly increased when mixed with the GFP-MSCs compared to that of mixed lymphocyte culture assays in the SCID or MF1 mice without xenogeneic MSCs implantation, suggesting that implantation of xenoge-neic MSCs has promoted host anti-graft immunogenic responses towards to otherwise immunosuppressive MSCs.
In conclusion, xenogeneic rat MSCs transplanted in immunocompetent mice has survived for prolonged period, but their function was comprised to certain extent and this may be due to the increased host anti-graft immune sensitization after exposed to the xenogeneic MSCs.
The aim of this study was to compare the results of humerus intramedullary nail(IMN) and dynamic compression plate DCP) for the management of diaphyseal fractures of humerus.
Material & Methods- 47 patients with diaphyseal fracture of shaft humerus were randomised prospectively and treated by open reduction and internal fixation with IMN or DCP. The criteria for inclusion was Grade 1,2a compound fractures, polytrauma, early failure of conservative treatment, unstable fracture. The patient with pathological fracture, Grade 3 open fracture, refracture, old neglected fracture of humerus were excluded from the study. 23 patients underwent internal fixation by IMN and 24 by DCP. Reamed antegrade nailing was done in all cases. DCP was done through an anterolateral or posterior approach.
Results -The outcome was assessed in terms of functional outcome and the incidence of complications. Functional outcome was assessed using the Americans Shoulder and Elbow Surgeons Score (ASES). On comparing the results, there was no significant difference in ASES score between the two groups. The rate of complications was found to be higher in patients treated with IMN than with DCP. The complications that were encountered with IMN were non union, shortening of the arm, impingement of the shoulder, implant failure. The rate of secondary surgery was also found to be significantly higher with IMN.
Conclusion – There is sufficient evidence to suggest that DCP still remains to be the operative treatment of choice for diaphyseal fractures of humerus. IMN may be indicated only in specific situations like segmental fractures, pathological fratures though this study did not aim to look into that aspect.
Cartilage is a realistic target for tissue engineering given the avascular nature and cellular composition of the tissue. Much of the work in this field has been largely empirical, indicating the need for alternative approaches to the design of cartilage formation protocols. Given the heterogeneity associated with human mesenchymal populations, continuous cell lines may offer an alternative to model and simplify cartilage generation protocols. We therefore exploited the potential of the murine chondrocytic ATDC5 cell line to, i) delineate the process of chondrocyte differentiation in monolayer culture and three-dimensional micromass pellet culture systems, and ii) model cartilage formation utilising appropriate scaffold and bioreactor (perfused and rotating) technologies. Monolayer cultures of ATDC5 cells over a 28-day period in presence of insulin demonstrated various stages of chondrocyte differentiation- proliferative, pre-hypertrophic, hypertrophic and finally, mineralisation of cartilaginous nodules. This was confirmed by gene and protein expression, by qPCR and Western blotting respectively, of chondrogenic differentiation markers- Sox-9, Bcl-2, Type II and X collagens. Pellet cultures of ATDC5 cells under chondrogenic conditions (10 ng/ml TGF-beta3, 1X ITS {insulin, transferrin, selenium}, 10 nanomolar dexamethasone, 100 micromolar ascorbate-2-phosphate) illustrated a gradual progression from an aggregation of cells at day 7, to initiation of matrix synthesis at day 14, followed by formation of well-defined cartilaginous structures at day 21. Chondrogenic differentiation at day 21 was evident by numerous proliferative/ pre-hypertrophic chondrocytes, staining for Sox-9, Aggrecan, Type II collagen and PCNA, lodged in distinct lacunae embedded in cartilaginous matrix of proteogly-cans and Type II collagen. Inclusion of TGF-beta3 in the chondrogenic medium during pellet culture beyond 21 days maintained the pre-hypertrophic phenotype, even at day 28. In contrast, removal of TGF-beta3, addition of 50 nanomolar thyroxine and reduction of dexa-methasone to 1 nanomolar in the chondrogenic medium stimulated hypertrophy at day 28, evident by down-regulation of Sox-9 expression. ATDC5 cells cultured on Polyglycolic acid fleece in the rotating bioreactor or encapsulated in chitosan /alginate and cultured in the perfused bioreactor for 21 days, formed cartilaginous explants reminiscent of hyaline cartilage. Thus, ATDC5 cells constitute an ideal cell line to elucidate the steps of chondrocyte differentiation and cartilage formation.
Hip resurfacing arthroplasty (HRA) is increasingly carried out as an alternative to total hip arthroplasty (THA) in young patients. During the procedure, a metal stem on the retrosurface of the HRA is inserted into the femoral head to ensure the implant is located centrally with respect to the femoral neck. It has been suggested that the stem may interfere with bone loading. In light of this, the current study employed finite element (FE) models to investigate the change in the HRA-implanted bone mechanics as a result of removing the stem. FE models of a cadaveric femur pre- and post-HRA surgery were analysed to determine changes in bone stress/ strain.
The implanted models simulated geometry for a cemented HRA with and without a non-cemented stem (HRA-Stem and HRA-NoStem, respectively) and included more accurate multiple material parameters to simulate the non-homogeneous material distribution in the femoral bone. The models included loading conditions simulating an instant at 10% of the gait cycle. Bone stresses/strains in the femoral head and neck of the implanted models were compared with the intact condition to assess the change in bone mechanics. Changes in cement mantle stresses between the HRA-Stem and HRA-NoStem models were also compared.
When comparing similar volumes of bone in the femoral neck, both HRA models showed a similar variation in stress from the intact condition and bone stresses were low in comparison to the ultimate strength of cortical bone. There was less change in peak strain energy in the femoral head of the HRA-NoStem model than the HRA-Stem model. Cement mantle stresses in the HRA-NoStem model were slightly higher than for the HRA-Stem model and the peak compressive stress was close to the fatigue limit for bone cement.
These preliminary results suggest that the bone loading is more normal without the stem. However, there are increased cement mantle stresses.
We have used human Embryonic Stem cells (hESC) and human Mesenchymal Stem Cells (hMSC) in rat models of bone repair in order to assess the efficacy of these cells for treatments of trauma and skeletal diseases. Graft survival is considered to be of key importance to efficacy of these treatments. Therefore the aim of this study was to develop a technique for identifying implanted cells in histological preparations without the need for genetic engineering of the implanted cells.
We present a unique prospective study which estimates the median sustained stage related improvement in pain and hand function predicting symptomatic relief period with high accuracy with a single steroid injection.
Patients were grouped into stages, I to IV according to the Eaton and Glickel radiological criteria. The steroid injection contained 40mg triamcelone and 1% lido-caine. The response was assessed by DASH and a visual analogue score before and at six-week interval. We used the Kaplan-Meier method to estimate median length of sustained improvement by grade of disease, with 95% confidence interval. All the patients were injected by an upperlimb physiotherapist (DD). Post injection review was carried out by an independent observer(MK).
Forty patients were studied: 33 females and 7 males. The age ranged from 53 to 81 years, (mean 65years). No patient was lost to follow-up. Mean duration of symptoms were 36 months. Six patients has stage I disease(15%), eighteen patients had stage II disease (45%), ten patients had stage III disease (25%) and six patients has stage IV disease (15%). Pain score ranged from 4 to 9 on visual analogue score. Reduction in pain visual analogue score was noticed in all but 3 patients. With the exception of Grade III patients, DASH scores decreased significantly at 6 weeks (Grade I 14.9, Grade II 19.3, Grade III 6.2 and Grade IV 10.0.). With the exception of Grade IV patients, pain scores decreased significantly at 6 weeks. In Grade II patients, over half had sustained symptomatic relief at 6 months. So on average, we can expect grade I patients to sustain symptomatic relief for an average of 17 weeks. The true average is likely to be between 13 and 21 weeks. For grade II patients, most will still have improved at 6 months. Grade III and IV patients have an identical prognosis of 4 weeks, though the true prognosis may be between 2 and 6 weeks.
In conclusion it is possible to predict the period of symptomatic improvement in each of the four disease stages. This allows the treating clinician to discuss the outcome of treatment with reasonable accuracy.
In patients with DM (Diabetes Mellitus types I & II), primary frozen shoulders tend to be refractory to all forms of treatment. We collected tissue from the joint capsule of shoulder joints from a variety of patients undergoing surgery as follows:
Diabetic Group (DFS): patients with DM who have primary frozen shoulders. Other patients suffering from primary frozen shoulders (FS) Control group (NS). Patients undergoing shoulder surgery that does not involve stiffness of the gleno-humeral joint.
Tissue was collected from near to the rotator interval under arthroscopic control. Fibroblast lines were established by serial passage. Thereafter they were exposed to graded concentrations of insulin in vitro for 24 hours and the supernatant retained for assay. Fibroblast lines were analysed from 3 subjects in each group (n=9). Luminex multiplex analysis was performed for MMPs (Matrix Metalloproteinases). TIMP-1 (Tissue Inhibitor of MetalloProteinases) expression. Informed consent was obtained from all subjects.
This is the first time these enzymes have been measured and quantified in cells derived from shoulder tissues. Primary Frozen Shoulders produce less MMPs and have a smaller MMP/TIMP ratio than controls. Similarly the diabetic patient derived cells produce less MMP-1, at an even lower level. These deficiencies in MMP1 production may reflect an altered capacity for local tissue re-modelling. MMP modulation may allow therapeutic intervention in the diabetic and frozen shoulder group of patients.
The clearance between the femoral head and the acetabular cup can significantly affect the lubrication, the wear and the lifetime of metal on metal (MOM) hip joints. The objective of this study was to compare the frictional behaviour of MOM joints with different clearance.
Two CoCrMo MOM 50mm diameter hip joints, with a small diametral clearance of 17 microns and a big diametral clearance of 212 microns, were used in this study. The friction measurement was carried on the wear patches of MOM bearings during a long-term wear simulator test. A dynamic trapezoidal-form loading cycle was applied to the femoral head with a minimum load of 100N during the swing phase and a maximum load of 2000N throughout the stance phase. A simple harmonic motion of amplitude +/−24 degree was applied to the femoral head in the flexion-extension plane with a frequency of 1 Hz. The friction torque was measured at 0, 0.8, 1.3, 1.9, 4 and 5.5 million cycles using 6 different viscosities of 25% new born calf serum.
The results show that the friction factors (f) of small clearance were generally higher than those of big clearance and this difference became wider with the progress of wear. The lower f of big clearance, especially in the lower range of Sommerfeld number (z) after 5.5 million cycles, is significant and will affect the ultimate performance of prostheses as this range has closer rheological properties to synovial fluid and represents long term wear conditions. At the same time, the friction factors were always higher every time when measured from high z to low z, although this difference became slightly smaller with the progress of wear, which indicates that there is still direct contact between the bearings. The lower friction factor when increasing z, is due to the wear and bedding-in with the progress of the measurement. It is concluded that large clearance has lower friction factor than small clearance, and full fluid film lubrication is unlikely to have developed between the MOM bearings in this study, even with a small clearance and high viscosity.
The purpose of the study was to test the hypothesis that cellular mechanisms of fibroblasts derived from primary frozen shoulder(PFS) exhibit similar activity in terms of contraction, response to cytokine (transforming growth factor-beta1) and mechanical stimulation similar to that generated by fibroblasts derived from dupuytren’s disease. PFS is a debilitating disease of unknown aetiology, characterised by fibrosis with contracture of the cora-cohumeral ligament, tissues of the rotator interval and glenohumeral ligaments, leading to restrictive shoulder movements. Frozen shoulder has been postulated to be Dupuytren’s disease of the shoulder with an association inferred since 1936.
An estimated 10% of patients have problems with fracture healing. Initial studies have revealed that it is likely that both the innate and specific immune systems play a role in fracture repair, but this has not been attributed to particular components, cells or their products. It is known that the functionality of the immune system is impaired with age and this may account for the higher rate of delayed union in elderly patients.
We used a validated mouse model of a reproducible closed tibial fracture. In order to prevent any foreign body inflammatory/immune response no artificial internal fracture fixation was used and instead external support was provided using a Plaster of Paris cast. The role of the specific immune system was studied using an immunodeficient Balb/c SCID (Severe Combined Immuno Deficient) mutant mouse. The SCID mice were matched for age, sex (all males) and weight to the control, wild type Balb/c mice. Mechanical (4 point bending) and radiographic (Radiographs scanned and calculations of callus area, index and density made with image analysis software) measures were used to assess fracture repair at 21 days.
Mechanical measurements revealed an enhancement of fracture healing in the SCID mouse strain compared to the control strain, with stress at yield and Young’s modulus higher in SCID mice than controls. (Stress at yield: 4.2 +/− 0.23MPa in Controls, 7.1 =/− 0.6MPa in SCIDs, P< 0.01; Young’ Modulus: 22.1 +/− 2.99MPa in Controls, 60+/− 9.9MPa in SCIDs P< 0.01). There were no significant differences seen in mechanical properties of unfractured bone between the two strains. Radiographic analysis revealed no significant differences in callus area or index (both measurements of callus size) but callus density was significantly higher (P< 0.01) in the SCID subjects compared to controls (2.6 +/− 0.06E5 Greyscale in SCIDs vs. 2.2 +/− 0.09E5 in controls).
We conclude that an abnormality of the immune system due to either lack of the specific immune system (T and B cells) or an enhancement of the innate system results in increased mineralization, stiffness and strength of fracture healing, and that further investigation might result in novel therapies directed toward avoidance of non/delayed-union.
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 350,000 people in the UK. Within synovial joints, synoviocytes form a destructive pannus that degrades articular cartilage and bone. Synovial fluid glutamate levels increase 54 fold in RA patients and are also elevated in animal models of inflammatory and osteoarthritis. To determine whether elevated glutamate levels contribute to RA pathology we investigated which synovial joint tissues express glutamate receptors and whether glutamate stimulation influences synovio-cyte phenotype.
Various glutamate receptor mRNAs (NMDAR1, KA1, AMPAGluR2, AMPA GluR3, mGluR4) were expressed in tissues of the rat knee. All receptors were expressed in the patella. The fibrocartilagenous menis-cus and articular cartilage chondrocytes expressed mGluR4 and both AMPA receptor subunits. Human synoviocytes expressed NMDAR1 and KA1 mRNA.
To determine whether glutamate receptors were functional in human synoviocytes, cells were preloaded with a fluorescent indicator of intracellular calcium (iCa 2+) and stimulated with glutamate or specific agonists (NMDA or kainate, 500mM). Glutamate stimulated release of iCa2+ in 25% of synoviocytes whereas NMDA and Kainate each stimulated 15% of cells. NMDA responses increased to 57% in the absence of Mg2+ consistent with the inhibitory effect of Mg2+ on this receptor.
To determine whether activation of glutamate receptors can influence human synoviocyte phenotype, we cultured synoviocytes in various glutamate concentrations (50mM to 2mM) and measured effects of glutamate receptor antagonists on release of a proinflammatory cytokine (IL-6) and degradative enzymes (MMP2 and 9). In some RA patients, glutamate stimulation increased synoviocyte pro MMP-2 release. TIMP1 and TIMP2 release were not affected by glutamate stimulation or co-treatment with receptor antagonists.
IL-6 expression varied greatly in human synoviocytes derived from different RA patients (0–120pg/ml media). However, the AMPA/KA receptor antagonist NBQX significantly reduced IL-6 release at all glutamate concentrations. This inhibition was greater than that by CFM2 (AMPAR antagonist), indicating that activation of kainate receptors in human synoviocytes may induce IL-6 release.
We conclude that glutamate receptors are functional in human synoviocytes and regulate release of MMP-2 and IL-6 Thus glutamatergic signalling may contribute to RA pathology and represent a new therapeutic target.
Osteoarthritis (OA) is characterized by progressive erosion of articular cartilage due to degradation of the cartilage matrix. The major enzymes involved are the matrix metalloproteases and aggrecanases, which are either derived from the synovium or synthesized by chondrocytes as OA progresses. This abnormal enzyme synthesis is part of a phenotypic change from normal to ‘degradative’ chondrocytes. If this change could be prevented, then disease progression might be slowed.
In early OA, degradative chondrocytes are only present in the superficial zone, but with increasing severity of OA, more chondrocytes become degradative cells so that, in high-grade OA, these cells are also located in the deep zone. We hypothesized the existence of a ‘factor X’, which diffuses from the superficial to the deep zone and induces cells to change phenotype and express the pro-teases. We further hypothesize that this factor is released by degradative chondrocytes. To test the hypothesis, we co-cultured explants of human superficial-zone OA cartilage (which contains degradative cells and thus factor X) with explants of deep-zone cartilage from fracture neck of femur patients (#NOF), which contains mostly normal chondrocytes that do not express the proteases. We investigated MMP expression by real time RT-PCR and protein synthesis by immunohistochemistry.
Before culture, MMP-2, -3, -9, or -13 were expressed in the superficial-zone OA cartilage, but not in deep-zone #NOF cartilage, as expected. After 4 weeks with separate culture of superficial zones and deep zones, no MMPs was expressed in deep zone chondrocytes, suggesting that culture per se did not induce expression of these enzymes. Neither did culture abolish expression in the superficial zone, as confirmed by RT-PCR and immunohistochemistry. However, when superficial-zone cartilage was co-cultured with deep-zone cartilage, MMP-3 expression were induced in deep- zone chon-drocytes, suggesting that a diffusible factor X, derived from degradative chondrocytes, had induced normal articular chondrocytes to express MMP-3. These experiments provide evidence for the existence of a factor that, when diffusing through the cartilage matrix, has the potential to induce normal non-enzyme expressing cells to become degradative chondrocytes.
The skeletal system exhibits functional adaptation. For bone the mechanotransduction mechanisms have been well elucidated; in contrast, the response of tendon to its mechanical environment is much more poorly understood despite tendon disorders being commonly encountered in clinical practice. This study presents a novel approach to developing an isolated tendon system in vivo. This model is used to test the hypothesis that stress-shielding, and subsequent restressing, causes significant biomechanical changes. We propose a control mechanism that governs this process.
A custom-built external fixator was used to functionally isolate the ovine patellar tendon(PT). In group 1 animals(n=5) the right PT was stress-shielded for 6 weeks. This was achieved by drawing the patella towards the tibial tubercle, thus slackening the PT. In group 2 (n=5) the PT was stress-shielded for 6 weeks. The external fixator was then removed and the PT physiologically loaded for a further 6 weeks. In each case, the PT subsequently underwent tensile testing and measurement of length(L) and cross-sectional area(CSA). The untreated left PTs acted as controls (n=10).
6 weeks of stress-shielding significantly decreased material and structural properties of tendon compared to controls (elastic modulus(E) 76.2%, ultimate tensile strength(UTS) 69.3%, stiffness(S) 79.2%, ultimate load(UL) 68.5%, strain energy(SE) 60.7%; p< 0.05). Ultimate strain(US), L and CSA were not significantly changed. 6 weeks of subsequent functional loading (Group 2) caused some improvement in material properties, but greater recovery in structural properties (E 79.8%, UTS 91.8%, S 96.7%, UL 92.7%, SE 96.5%). CSA was significantly greater than Group 1 tendons at 114% of control value.
Previous models of tendon remodelling have relied on either joint immobilization or direct surgical procedures. This model allows close control of the tendon’s mechanical environment whilst allowing normal joint movement and avoiding surgical insult to the tendon itself. The hypothesis that stress-shielding, and subsequent restressing, causes significant biomechanical changes has been upheld. We propose that the biomechanical changes observed are governed by a strain homeostasis feedback mechanism.
The Ilizarov technique of distraction osteogenesis is becoming a more common way of treating complicated fractures. It has been shown that shear IFMs will delay bone healing whilst axial IFMs are beneficial to the bone healing. Therefore to measure IFMs in conditions of mobility will provide critical information for research and clinic diagnosis. Such data are not provided by static measurements. Traditionally the IFMs were measured by implanting transducers to the bone or using radiological methods. However, these methods are not suitable for either clinic utilization or measurement of IFMS when patients are doing movements which simulate their daily activities. We have designed a dynamic IFMs measuring device.
It includes a displacement transducer array, which is connected to the Ilizarov wires. This transducer array consists of 6 parallel linear displacement transducers, each of which is attached to the fixing wires of the fix-ator. This arrangement of transducers can fit into the configuration of Stewart Platform. The Reverse Stewart Platform algorithm was employed to calculate IFMs. Without measuring the bone fracture segments directly, the two segments were fitted into two planes virtually. By studying the relative movements of the two virtual planes, the algorithm transfers the relative movement to relative axial & shear translation, and relative bending & torsion rotation, between the two fracture segments. Wireless interface was used to transfer the displacement readings from the transducer array to the computer. This setup allows patient perform activities which represent their routine activities.
In laboratory studies, we found the error of this system to be related to the IFMs. For small movements around 100 micron, the absolute error was 50 micron, whereas for larger movements around 1 mm, the error was within 0.22mm.
This real time monitoring method will allow kinematical and kinetic studies on fracture patients treated with Ilizarov frame. Measurements obtained using this novel device will reflect the natural pattern of IFMs during the patients’ daily life. Since use of the device requires no additional pin, wire or operative procedure, it will be clinically applicable. The accurate real-time IFMs measurements will help elucidate the complex interplay between movement and bone formation.
Imaging of the musculoskeletal system is vital for delivering optimum treatment particularly in the assessment of fracture healing. X-ray and CT are adequate imaging methods for bone but, soft tissue needs other modalities such as MRI and Ultrasound. We propose the use of Freehand 3D Ultrasound to study the early stages of fracture healing by imaging the bone surfaces around the fracture site and monitoring changes in the surrounding soft tissue.
Freehand 3D ultrasound is acquired by attaching a position sensor to the probe of a conventional 2D diagnostic ultrasound machine. As the probe is moved, its position and orientation are recorded along with the 2D ultrasound images. This enables slices through the body to be viewed that would be inaccessible using a normal ultrasound system. Bone surfaces around a fracture site are scanned and the data reconstructed using the Stradx and Stradwin software developed by Cambridge University, to give a 3D visualization of the area.
To assess the feasibility of this proposed method the lower limbs of healthy volunteers were scanned using a 5–10MHz ultrasound probe. The scanning resolution of the system was evaluated using a phantom to ensure millimetre detail could be detected as would be required for imaging early fracture healing. It was found that detail down to 0.8mm could easily be resolved for measurement.
The 3D system could accurately profile the different soft tissue interfaces. The visible surfaces of the tibia were reconstructed to give 3D models. Additional layers of soft tissue interfaces could easily be added to these models to provide more detail.
This imaging modality can provided detailed 3D models of bone the bone surface and surrounding soft tissue. As ultrasound is non-ionizing, rescanning can be conducted more frequently than with CT or x-ray thus offering a more accurate assessment of a patient’s response to healing.
These findings suggest that people with more severe fractures and low BMD may gain most mechanical benefit from vertebroplasty.
The thrombin-related peptide, TP508, a synthetic 23 amino acid peptide, has been shown to promote soft tissue, cartilage and fracture repair. We have previously demonstrated that two injections of TP508 have signifi-cantly enhanced bone consolidation in a rabbit model of distraction osteogenesis. This study was to test if a single injection of TP508 in a slow-releasing preparation will have the similar effects.
Unilateral tibial osteoectomies were stabilized with M100 Orthofix lengtheners in 17 male adult NZW rabbits. After 7 days, lengthening was initiated at a rate of 1.4 mm/day for 6 days. The following treatments were given: Group 1: TP508 in saline (300ug/300ul, n=6) was injected into the osteotomy gap at day of surgery and into the lengthening gap at end of lengthening. Group 2 (Control): Dextran gel (300ul, n=6) and Group 3: 300ul Dextran gel mixed with microspheres containing 300ug TP508 (n=5), was injected into the lengthening gap at end of lengthening. All animals were terminated 2 weeks after lengthening. Bone formation was assessed by weekly radiography and the specimens were subject to pQCT, microCT and histology examinations.
On radiographies there was more bone formation in the TP508 treated groups than that of the control group at 1st week post-lengthening and complete union was seen in 50% rabbits in Group 1, 33% in Group 2, and 60% in Group 3 at termination. The mean BMD of the regenerates was significantly higher in the TP508 treated groups than that of the control group (p< 0.05). MicroCT analysis demonstrated advanced bone formation in the TP508 treated animals. For histology, the regenerates were mainly consisted of woven bone of neocortilization and callus remodelling in Groups 1 and 3, whereas in Group 2, focal defects with cartilaginous tissues were frequently seen.
In conclusion we have demonstrated that a single injection of TP508 in the form of slow releasing micro-spheres has enhanced bone consolidation during distraction osteogenesis. TP508 may therefore be applied in the slow-releasing preparation for augmenting bone formation at reduced doses, costs and risks of infections through repeated injections.
One way to improve orthopaedic materials is to understand the exact architectural parameters that influence bone cell behaviour. In this study substrates with highly controlled surface features were created using photo-lithographic processes. These surfaces were contrasted for their ability to influence osteoblast activity and inter-cellular communication.
An etched silicon wafer was created by photolithography and used to hot-emboss grooved substrates (10-30micrometers wide/ 5-16micrometers deep) in poly-carbonate (PC). Smaller features were created on polydimethylsiloxane (PDMS) by casting over a photo-resist patterned silicon wafer. Rat osteoblasts were routinely cultured on flat or micro-fabricated substrates or in media supplemented with osteogenic stimuli for 35 days. Alkaline phosphatase activity was colourimetri-cally localised, and mineralised matrix visualised with Von Kossa staining. Connexin-43 was immunolocalised with a CY-2 conjugated antibody. Intracellular communication was studied using a dye (Lucifer yellow) transfer technique and fluorescence microscopy.
Osteoblasts were aligned on the grooved surface. In 10micrometers grooves, cells were in single rows while at 30micrometers the rows were two/three cells wide. Culture of osteoblasts on these surfaces under osteogenic conditions demonstrated alkaline phosphatase activity comparable to flat surfaces but after 28-35 days there was little evidence of bone-like nodules on the grooved substrates. We hypothesized that on grooved substrates cell:cell communication is compromised thus gap-junctions were studied. Image analysis showed that there was lower connexin-43 expression in cells on grooved substrates and fewer discrete gap junction complexes compared to flat surfaces (p< 0.05 ANOVA.). There were also differences between the grooves with con-nexin-43 most abundant on the widest (30micrometers) and deepest grooves (16micrometers). Analysis of dye transfer demonstrated that whilst cell:cell coupling was maintained within grooves it was reduced at the boundaries of the groove. A surface of asymmetric arrays of micro-columns (diameter 5micrometers) was fabricated to retain lateral interactions between osteoblasts whilst still aligning cells. Osteoblast differentiation now resulted in the formation of numerous bone-like nodules and matrix was aligned in the direction of the shortest column distances.
Maintaining appropriate cell:cell communication structures is pivotal in the process of osteoblast differentiation and the design of novel biomaterial surfaces should ensure that cells can maintain these critical interactions.
The matrix metalloproteinases (MMPs) and ADAMTSs (a disintegrin and metalloproteinase with thrombos-pontin motif) are related enzymes collectively responsible for turnover of the extracellular matrix. The balance between the proteolytic action of the MMPs and ADAMTSs, and their inhibition by the tissue inhibitors of metalloproteinases (TIMPs), underpins many pathological processes. Deviation in favour of proteolysis is seen in e.g. invasive carcinoma, whereas an imbalance towards inhibition causes e.g. fibrosis.
Dupuytren’s Disease (DD) is a fibroproliferative disorder affecting the palmar fascia, leading to contractures. A group of patients with end-stage gastric carcinoma were treated with a broad spectrum MMP inhibitor in an attempt to reduce the rate of tumour advancement: a proportion developed a ‘musculoskeletal syndrome’ resembling DD. Several groups have looked at subsets of the metalloproteinase family in relation to DD, but to date, a study of the gene expression of all of the members has not been published. We therefore set out to profile the mRNA expression for the 23 known MMPs, 4 TIMPs & 19 ADAMTSs in DD and normal palmar fascia.
Tissue samples were obtained from patients undergoing surgery to correct contractures caused by DD and from healthy controls undergoing carpal tunnel decompression. The DD tissue was separated macroscopically into cord and nodule. Total RNA was extracted and mRNA expression analysed by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR), normalised to 18S rRNA. Comparing across all genes, the DD nodule, DD cord and normal palmar fascia samples each had a distinct mRNA expression profile. Statistically significant (p< 0.05) differences in mRNA expression included: higher MMP-2, -7 and ADAMTS-3 levels in both cord and nodule; higher MMP-1, -14, TIMP-1 and ADAMTS-4 and -5 in nodule alone, lower MMP-3 in nodule and cord and lower TIMP-2, -3 and -4 and ADAMTS-1 and -8 levels in nodule alone.
The distinct mRNA profile of each group suggests differences in extracellular proteolytic activity which may underlie the process of fascial remodelling in DD. Further in vitro experiments are planned based on these observed differences in gene expression.
Physical activity is a key determinant of bone mass and health, however during adulthood and ageing there appears to be a decrease in the ability to respond positively to exercise which is variable between individuals. While exercise is known to protect against the osteopo-rotic process with modest increases in BMD the exact cellular and molecular responses are poorly understood.
We have studied the effect of mechanical stimulation on bone histomorphometric parameters, osteocyte viability and gene expression in human trabecular bone maintained in a 3D bioreactor.
Trabecular bone cores were prepared from femoral head tissue removed from patients undergoing total hip arthroplasty and maintained in the bioreactor system for 3 (n= 4 patients), 7 (n=5 patients) or 28 days (n=1 patient). Cores (n=3 per patient) were either frozen directly on preparation (T0), placed in the bioreactor system and subjected to Mechanical stimulation (3000 μstrain in jumping exercise waveform repeated at 1Hz for 5 minutes daily) or maintained in the bioreactor system with no mechanical stimulation as control. After the experimental period total cell numbers, cell viability and apoptosis were determined in un-decalcified cryosections at specific distances throughout the bone cores by nuclear staining (DAPI), lactate dehydrogenase activity (LDH) and Nick Translation Assay respectively. Consecutive sections were collected and RNA extracted for gene expression analysis.
Mechanical stimulation was shown to increase Bone Formation Rate (BFR) as determined by Calcein label/ distance to bone surface in the 28 day experiment (BFR mcm/day Control 0.01 ± 0.0035 vs Load 0.055 ± 0.0036 p=0.0022). Expression of bone formation markers such as Alkaline Phosphatase and Collagen Type I was shown to increase in all patients however there was an individual variation in the response of Osteopontin to mechanical stimulation as determined by quantitative real time PCR expression analysis. Numbers of viable osteocytes at T0 varied between individual patients however viability was significantly increased and apoptosis decreased in association with mechanical stimulation compared to control in all patient samples examined (p to 0.021). Our data tend to support animal model findings relating to the osteocyte saving effects of exercise and provide an insight into the molecular detail of the exercise response in human bone.
Bone morphogenic proteins (BMPs) are members of the transforming growth factor beta (TGF-beta) family and play a central role in bone formation. These morpho-gens are known to be present in bone matrix however the characteristics of their release during the grafting process has not previously been defined. The aim of this study was to determine the release BMP-7 (osteogenic protein; OP-1) from cancellous allograft that occurs during impaction grafting for revision hip arthroplasty.
Forty, 10mm cubes of cancellous bone were accurately cut from the central region of 7 fresh frozen femoral heads. The cubes were centrifuged and washed to remove the marrow contents. The cubes were then individually washed and the fluid assayed for BMP-7 activity using a commercially available enzyme linked immuno-sorbent assay kit (Raybiotech Inc.). The cubes were then divided into 4 groups with samples from each femoral head in each group. Each group was subjected to strain of either 20%, 40%, 60% or 80% using a material testing machine. The cubes were then individually washed again and the wash fluid analysed for BMP-7 activity.
BMP-7 activity was found to be present in all groups. Release of BMP-7 was found to increase with increasing strain. At 80% strain the mean concentration of BMP-7 released (830 pg/g) was 58% greater than that released at 60% strain (527 pg/g), 150% greater than the concentration at 40% strain (333 pg/g) and 476% greater than at 20% strain (144 pg/g). The differences between release at 80% and 40% strain and between 80% and 20% strain were statistically significant (p=0.036, p=0.002).
Activity of BMP-7 in fresh frozen cancellous allograft bone has not previously been demonstrated. This study shows that the freezing and storage of femoral heads allows some maintenance of biological activity. Furthermore we have shown that BMP-7 may be released in proportion to the strain applied to the bone. This confirms that the process of impaction of bone morsels during revision hip arthroplasty may release BMPs that could aid in the incorporation and remodelling of the allograft.
Cartilage and bone degeneration are major healthcare problems affecting millions of individuals worldwide. Elucidation of the processes modulating the cell-matrix interactions involved in cartilage or bone formation offer tremendous potential in the development of clinically relevant strategies for cartilage and bone regeneration. We have therefore adopted an ex vivo tissue engineering approach to investigate chondrogenesis and osteogenesis using a mix human mesenchymal progenitor populations encapsulated in biomineralised polysac-charide templates with or without the addition of type-I collagen.
Alginate/chitosan polysaccharide capsules containing 2.5mg/ml type-I collagen and TGF-beta-3 were encapsulated with human bone marrow cells (HBMC), articular chondrocytes or a co-culture at a ratio of 2:1 respectively and placed in a rotating (Synthecon) biore-actor or held in static 2D culture conditions for 28 days, to determine whether the presence of type-I collagen within the alginate could promote the synthesis of an extracellular matrix.
Constructs were stained with alcian blue, sirius red and von Kossa. In bioreactor samples encapsulated with HBMC and type-I collagen, viable cells were present within lacunae, surrounded by a matrix of proteo-glycans and fibrous collagen, which was mineralized. Immunohistochemistry and polarised light microscopy indicated an organised collagenous matrix with extensive expression of type I collagen and bone sialoprotein with small regions of type II collagen. Type X collagen was also expressed indicating the presence of hypertrophic chondrocytes. Within the static HBMC groups, smaller areas of matrix were generated with decreased expression of type-I and type-II collagen. Co-culture bioreactor samples also demonstrated regions of new mineralised bone matrix; however these were less prominent than in the HBMC only groups. No matrix formation was observed in chondrocyte cultures although the cells remained viable as assessed by live/dead staining. Biochemical analysis indicated significantly increased (p< 0.05) DNA in all bioreactor samples in comparison with static constructs and significantly increased protein in HBMC bioreactor constructs in comparison with other cell types.
These studies outline a unique tissue engineering approach, utilizing individual and mixed human mesen-chymal progenitor populations coupled with innovative polysaccharide templates containing type I collagen and bioreactor systems to promote chondrogenic and osteo-genic differentiation.
The use of fresh morsellised allograft in impaction bone grafting for revision hip surgery remains the gold standard. Bone marrow contains osteogenic progenitor cells that arise from multipotent mesenchymal stem cells and we propose that in combination with allograft will produce a living composite with biological and mechanical potential. This study aimed to determine if human bone marrow stromal cells (HBMSC) seeded onto highly washed morsellised allograft could survive the impaction process, differentiate and proliferate along the osteogenic lineage and confer biomechanical advantage in comparison to impacted allograft alone. Future work into the development of a bioreactor is planned for the potential safe translation of such a technique into clinical practice.
Hypoxia has been shown to improve chondrogenesis in stem cells derived from the bone marrow. We explore the hypothesis that this effect would also apply to stem cells derived from the infrapatellar fat pad.
Massive disc herniations after surgical decompression develop secondary back pain due to important loss of nucleus material with instability. No earlier proposed method to restore disc function was biological.
Chondrocyte culturing allows living repair of lost disc tissue. The contained disc space appears particularly suitable for receiving those tissue cultures. Surprisingly disc replantations had not been attempted before.
In 1996 two women and one man (aged 38-55) underwent open resection of a massive disc herniation by hemi-laminotomy, twice at L5-S1, once at L4/5.
All the excised disc tissue was given to tissue culture in an identical protocol as in autologous chondrocyte transplantation (ACT) for articular cartilage repair. After sufficient cell multiplication (11.5-23 millions living cells in 750 μl) four weeks later the engineered autolo-gous disc tissue was injected in suspension through a contra-lateral puncture under local anaesthesia.
In prospective follow up a simplified Oswestry Disability Index was recorded and functional radiographs and NMR were taken after one, three, six and nine years.
All three patients remained freed from radicular pain and vertebral symptoms over the whole follow up period. Two patients never had functional restrictions nor loss of working capacity (Oswestry 1 and 6), one after retirement at 5 years developed rheumatoid disease but is still unchanged at the lumbar spine. The third patient partially recovered from preoperative radiculop-athy (slight loss of strength and sensitivity S1) but still works, with minor adaptations to his original professional activity (Oswestry 18).
Functional radiographs up to the last follow up didn’t show vertebral instability. In all cases the replanted intervertebral disc space remained unchanged with minimal widening in one case.
In NMR all three discs had partial signal recovery. Twice during the first year a new outgrowth of disc tissue was observed at the site of the primary disc herniation opposite to the replanting injection, without any clinical correlation.
Three cases with massive lumbar disc herniations showed good clinical and large anatomical recovery persisting nine years after reimplantation of engineered autologous disc tissue. The encouraging results of this small pilot study led to further closely monitored clinical applications before wider propagation of biological disc repair surgery.
Fine-wire fixators are a powerful tool in the management of acute fractures, non-unions, mal-unions and limb lengthening. The tension in the wires is very important in achieving stiffness of the whole fixator construct and current guidelines suggests tensioning wires to 900-1275N. There is evidence that during long term use the tension in the wires can reduce significantly. The effects of a reduction in tension on the fixator stiffness has been well characterised however the effect on the stresses imparted on the bone at the interface with the wire remain unknown. The main aim of this study was to identify any relationship between wire tension and wire-bone interface pressure.
An experimental system utilizing artificial cancellous bone mounted on a tensioned 2mm wire and then loaded by a material testing machine was employed. Pressure sensitive film allowed determination of interface stresses. The experiment was repeated at wire tensions of 600, 900 and 1200N. All other variables were kept the same during testing.
The highest pressures were found closest to the wire. At 1200N the peak pressures were 6-8 MPa, at 900N of tension the pressures rose to 8-10 MPa and at 600N pressures up to 14 MPa were observed. Deeper in the bone the pressures observed at 600N tension were double that seen at 1200N.
This is the first characterisation of the relationship between interface pressure and wire tension in fine-wire fixators. At 1200N the highest pressures are less than the compressive yield strength of cancellous bone whereas at both 600 and 900N pressures are greater than the yield which may lead to loosening. We therefore conclude that a tension of 1200N be employed when applying fine-wire fixators and during long term treatments the tensions should be regularly monitored to prevent loss of tension.
The ability to generate replacement human tissues on demand is a major clinical need. Indeed the paucity of techniques in reconstructive surgery and trauma emphasize the urgent requirement for alternative strategies for the formation of new tissues and organs. The idea of biomimesis is to abstract good design principles and optimizations from nature and incorporate them in the construction of synthetic materials and structures. Direct appropriation of natural inorganic skeletons is also biomimetic since their unique properties inform us on ways to generate functional, optimized scaffolds.
A number of well characterized natural skeletons were investigated as potential scaffolds for tissue regeneration using mesenchymal stem cell populations. Marine sponges, sea urchin skeletons and nacre were found to possess unique functional properties that supported human cell attachment, growth and proliferation and provided organic/ inorganic extracellular matrix analogues for guided tissue regeneration.
A good understanding of the processses involved in biomineralisation and the emergence of complex inorganic forms has inspired synthetic strategies for the formation of biological analogues (organised inorganic materials with biological form). We have developed two functional examples of biological structures generated using biomimetic materials chemistry with applications for human tissue regeneration. Mineralised biopoly-saccharide microcapsules provided enclosed micro-environments with an appropriate physical structure and physiological milieu, for the support of the initial stages of tissue regeneration combined with a capacity to deliver human cells, plasmid DNA and controlled release of biological factors such as cytokines. Calcium carbonate porous microspheres analogous to microscopic coccolithophore shells provided a template for tissue formation and a mechanism for the delivery of DNA and functional biological factors. These biomi-metic structures have considerable potential as scaffolds for skeletal repair and regeneration, particularly when combined with inductive and stimulatory biological factors (cytokines, morphogens, signal molecules) and plasmid DNA carrying with them chemical cues that modulate and direct permanent tissue formation complimentary with the host.
Finite element (FE) analysis is widely used to calculate stresses and strains within human bone in order to improve implant designs. Although validated FE models of the human femur have been created (Lengsfeld et al., 1998), no equivalent yet exists for the tibia. The aim of this study was to create such an FE model, both with and without the tibial component of a knee replacement, and to validate it against experimental results.
A set of reference axes was marked on a cleaned, fresh frozen cadaveric human tibia. Seventeen triaxial stacked strain rosettes were attached along the bone, which was then subjected to nine axial loading conditions, two four-point bending loading conditions, and a torsional loading condition using a materials testing machine (MTS 858). Deflections and strain readings were recorded. Axial loading was repeated after implantation of a knee replacement (medial tibial component, Biomet Oxford Unicompartmental Phase 3). The intact tibia was CT scanned (GE HiSpeed CT/i) and the images used to create a 3D FE mesh. The CT data was also used to map 600 transversely isotropic material properties (Rho, 1996) to individual elements. All experiments were simulated on the FE model. Measured principal strains and displacements were compared to their corresponding FE values using regression analysis.
Experimental results were repeatable (mean coeffi-cients of variation for intact and implanted tibia, 5.3% and 3.9%). They correlated well with those of the FE analysis (R squared = 0.98, 0.97, 0.97, and 0.99 for axial (intact), axial (implanted), bending, torsional loading). For each of the load cases the intersects of the regression lines were small in comparison to the maximum measured strains (< 1.5%). While the model was more rigid than the bone under torsional loading (slope =0.92), the opposite was true for axial (slope = 1.14 (intact) 1.24 (implanted)) and bending (slope = 1.06) loads. This is probably due to a discrepancy in the material properties of the model.
Osteoarthritis (OA) is characterised by the progressive loss of the articular cartilage. This is accompanied by change in phenotype from cells expressing chondrocytic genes to cells, termed ‘degradative’ chondrocytes, that express aggrecanases and collagenases. To understand the cellular events involved, human articular cartilage was obtained from femoral heads after arthroplasty due to OA, fracture of the neck of femur (#NOF) due to osteoporosis, or from a 14 year old male (CDH). Samples were graded according to the new OARSI system (
All chondrocytes, irrespective of OA grade, were immunopositive for S100, but there were differences in the other parameters. Cartilage from the 14-year old (OARSI grade =0) was characterized by no loss of proteoglycans (safranin-O) in the superficial zone and absence of c-Myc, Sox-9 and nucleostemin in all articular chondrocytes. In #NOF cartilage, proteoglycan loss was evident in the very superficial zone. Many chondro-cytes in that zone showed bright green fluorescence with CellTracker-green and were c-Myc positive, consistent with cellular activation. Sox-9 and nucleostemin were absent. Mid-zone and deep zone chondrocytes showed no change. In low-grade OA samples (OARSI = 1-2), the zone of proteoglycan loss had increased, the Cell-Tracker-green/c-Myc positive chondrocytes in that zone had divided to form clusters of 4-8 cells. Occasional cells were positive for nucleostemin. Mid-zone and deep zone chondrocytes still showed no change. In high-grade fib-rillated OA cartilage (OARSI = 3-4) the superficial and mid zones had been eroded, leaving the deep zone at the surface. Chondrocytes were typically found in large clones, which were all immunopositive for c-Myc as well as for nucleostemin and Sox-9.
The results show that cellular activation starts near the surface and progresses to the deep zone. The presence of nucleostemin and Sox-9 suggests that de-differentiation may be involved in the phenotypic change from the chondrocytic to the degradative phenotype.
Studies have demonstrated that use of peptides including bone morphogenetic proteins, fibroblast growth factors, insulin-like growth factor (IGF), and transforming growth factor-beta (TGF-beta), may be pivotal in promoting chondrogenesis and matrix development. As a prelude to studies, it is necessary to determine which gene or combination of genes gives the best result to improve proliferation of chondrocytes and synthesis of extracellar matrix. We investigate the effect of transfec-tion of recombined rat TGF-beta1 and recombined rat IGF-1 on rabbit chondrocytes ex vivo.
Chondrocytes were isolated from articular cartilage of knee joint of mature New Zealand White rabbits. Cells were seeded at a density of 1×105 cells/ml into 6-well plates. Monolayer cultures were infected respectively with recombinant rat gene pcDNA3+TGF-beta 1, pAT153+IGF-1 and lac Z reporter gene by using lipo-fectamine, and were co-transfected by pcDNA3+TGF-beta 1, pAT153+IGF-1. The control group remained uninfected. To determine whether the genes transcript were translated and the gene products were released, the synthesis of TGF-beta 1, IGF-1,and type II collagen were measured by in situ hybridization, immunohisto-chemistry and immunofluoroscopy. The proliferation of chondrocytes was detected by flow cytometer and 3H-TdR radiolabeling.
The expression of TGF-beta1,IGF-1 and type II collagen in recombinant rat gene transfection groups was high beyond control levels and the lac Z gene levels (P< 0.05). The co-transfection elevated these factors synthesis beyond the levels of single gene transfection (P< 0.05). In pcDNA3 +TGF-beta1 transfection group, the level of TGF-beta1 and type II collagen were higher than the levels of pAT153+IGF-1 group (P< 0.05), while the content of IGF-1 has no significant difference with pAT153+IGF-1 group. By using flow cytometer, the chondrocytes ratio of S stage in pcDNA3+TGF-beta 1 group, pAT153+IGF-1 group and co-transfection group was 33.4%,28.7% and 40.1% respectively, which was higher than 5.6% and 4.8% of the control group and the lac Z gene group (P< 0.05). The 3H-TdR radiolabeling detection also indicated that the recombinant rat gene transfection groups improved the chondrocytes proliferation, and co-transfection group has the best effect.
The data presented support that transfection of genes of TGF-beta1 and IGF-1 into chondrocytes ex vivo can greatly increase cell proliferation and matrix synthesis, and the co-transfection can provoke more increase in the synthesis of TGF-beta1, IGF-1 and type II collagen, which encourages the further research of gene potential therapeutic use for osteoarthritis.
Once damaged, articular cartilage has limited capacity for self-repair due to their avascular and acellular nature. Tissue engineering approaches using cultured chondrocytes and biomaterials as scaffoldings hold promises for repairing cartilage defects. However, the source of articular chondrocytes is limited and the chon-drocytes may de-differentiate when cultured for a prolonged period. Bone marrow derived mesenchymal stem cells (BMSCs) have multi-differentiation potentials and autologous BMSCs are easy to obtain and culture with no/little immunological reaction when re-implanted.
24 NZW rabbits were used. Rabbit autologous BMSCs were obtained through marrow aspirations and expanded in culture under the chondrogenic induction media (DMEM, 10% FCS, plus 10ng/ml TGF-β1) for 3 weeks. A full-thickness articular cartilage defect (3 mm in diameter and 3 mm in depth) was created on both medial condyles in the rabbit. For experimental group (16 joints), the defects were filled immediately with alginate capsules containing autologous chondrogenic cells (8.5 x 104); for the control groups, the defects were filled with either alginate capsules alone (16 joints) or left untreated (16 joints). All the animals were terminated at 6 and 12 weeks after surgery and the cartilage samples were harvested for histology, immunochemistry and in situ hybridization examinations.
For histology, in the experimental group the defects were filled with immature hyaline-like cartilaginous tissues at 6 weeks; by 12 weeks the newly formed cartilage showing signs of remodeling and integrating into the surrounding articular cartilage. The expression of type II collagen in the newly formed cartilaginous tissues was confirmed by immunohistochemistry and by in situ hybridization methods. In the control groups, the defects were mainly filled with fibrous tissues in all the animals at the two time points examined. We have used Wakitani cartilage grading system for semi-quantitative histological evaluation. Significant lower scores (with superior histology) were found in the experimental group comparing to the two control groups.
Our results confirmed that full-thickness articular cartilage defects can be repaired by chondrogenically differentiated autologous BMSCs seeded into alginate capsules. Further studies are ongoing to explore the long term outcome of this treatment approach as well as using new scaffolds for cartilage tissue engineering.
This study aimed to determine the prevalence of osteoporosis in patients awaiting hip and knee replacement for osteoarthritis and to review them two years later to determine the changes in bone density following joint replacement.
Patients aged between 65 and 80 years awaiting total hip or knee replacement were invited to participate. Lumbar spine, bilateral femoral and forearm bone mineral density (BMD) measurements were obtained using dual energy x-ray absorptiometry. BMD values were standardised using previously published T-scores and Z-scores. To assess clinical status, patients completed a questionnaire including the Western Ontario and McMaster University OA Index (WOMAC). All measurements were repeated at two-years.
Participants included 199 patients (84 hips and 115 knees) with a mean age of 72 years (SD 4.0) and were predominantly female (hips 67%, knees 50%). At baseline 46/199 (23%) patients (39 females) had evidence of osteoporosis (WHO definition) at one or more sites with the highest prevalence at the forearm (14%). At two-years 144 patients attended for review with 128 having undergone hip (56) or knee (72) replacement. At this review 39/144 (27%) patients (33 females) had evidence of osteoporosis at one or more sites with the highest prevalence at the forearm (22%). The greatest bone loss occurred at the forearm with median BMD change of minus 4% for females (25th percentile minus 7.3%, 75th percentile minus 1.9%) and minus 2.9% for males (25th percentile minus 4.6%, 75th percentile minus 1.1%). There was a significant difference in WOMAC Pain scores at follow-up between the osteo-porotic and non-osteoporotic knee patients (67 versus 81, p=0.002) indicating that osteoporotic patients had greater knee pain.
We have identified the forearm as not only the site with the highest prevalence of osteoporosis but also the greatest bone loss at follow-up. Further evaluation of forearm bone density measurements in the preopera-tive assessment and follow-up of patients awaiting joint replacement for hip and knee OA is required. Larger studies are needed to confirm our finding that the presence of osteoporosis is predictive of worse patient-reported outcomes of knee replacement.
A new hip simulator has been developed at the University of Portsmouth and manufactured at Simulation Solutions, Ltd. (UK) for the purpose of fatigue testing of implanted acetabula. Although hip simulators for in vitro wear testing of prosthetic materials in total hip arthroplasty (THA) have been available for many years, similar equipment has yet to appear for endurance testing of fixations in cemented THA, despite of considerable evidence of late aseptic loosening as one of the most singnificant failure mechanisms in acetabular replacements [1].
In this study, a new four-station hip simulator designed for in vitro fatigue testing of implanted acetabula is described. The four-station machine has spacious test cells that can accommodate full hemi-pelvic bones with implants. The machine was designed to simulate the direction and the magnitude of the hip contact force relative to the acetabular cup coordinate system, as reported by Bergmann et al. [2], under typical physiological loading conditions, including stair climbing as well as walking. The controls were designed as such that each station may operate independently with a loading waveform that is fully programmable. The motions were achieved through two encoded servomotors suitably connected to gearboxes; while the loading was realised through a close-looped pneumatic system. The motions and the resultant hip contact force of the new hip simulator were evaluated, and found to be satisfactory in reproducing the typical physiological loading waveforms including normal walking, ascending and descending stairs.
Experiments have been carried out using third generation composite bones (Pacific Research Laboratories, Inc.) and bovine bones. Both hip simulator and conventional fatigue testing were carried out. The implanted acetabula were CT scanned periodically to monitor the damage development in the fixation. Preliminary results seem to suggest that both magnitude and direction of the hip contact force influence the integrity of the fixa-tion, and failures appear to occur earlier in samples tested using the hip simulator. The predominant failure mechanism appears to be interfacial fracture, consistent with clinical observation of radiolucent lines and bone-cement interfacial failure.
The use of stem cells in tissue engineering has emerged as a promising therapy for the repair of bone and cartilage defects. Targeted delivery of stem cells requires a substrate to maintain the cells at the repair site, as well as to provide the physical cues, such as mechanical strain, for encouraging differentiation and expression of the mature cell phenotype. The strains that will be generated in cells residing on the scaffold is dependent on the scaffold material, as well as both the fibre thickness and the fibre orientation in the scaffold. To encourage uniform bone matrix generation throughout the scaffold, it is desirable that the strain be uniformly distributed and that the internal pore architecture be precisely controlled to maximise media diffusion. This requires an optimised scaffold design and a manufacturing technique that allows for precise control over the scaffold’s internal architecture.
Scaffold architecture was optimised by performing a series of finite element analyses (FEA) on computer aided design (CAD) models of Polycaprolactone (PCL) scaffolds. The mechanical properties of PCL were used to yield an accurate strain profile of scaffolds with different fibre orientations. Having determined the optimal scaffold geometry, PCL scaffolds were manufactured using a fibre deposition technique that yielded three-dimensional objects with this geometry. During manufacture, a PCL solution was extruded into a non-miscible solvent which precipitated out PCL fibres in repetitive layers. Of the geometries tested with FEA, a 90 degree rotation of adjacent layers with a 50% offset of parallel strands was found to provide the optimal strain distribution (60% increase in surface exposed to strain). Histomorphometry was used to assess the exact dimensions of the scaffold produced. Fibre spacing was found to be precisely controlled to 380 +/- 10 microns within the layers and the fibre thickness was controlled to 270 +/- 10 microns.
This demonstrates that FEA can be used to predict the strain distribution of different CAD models and that the fibre deposition solvent extrusion technique can be used to accurately manufacture PCL scaffolds that match the desired architecture.
Patella and extensor mechanism injuries are common injuries and are generally managed with some degree of immobilisation and partial weight bearing to facilitate healing. The aim of this project was to determine the type of immobilisation or splintage during partial weight bearing that results in minimal forces acting through the extensor mechanism.
Gait analysis studies were performed on eight healthy male subjects mobilising partially weight bearing. Measurements were taken for six types of immobilisation: locked at 0, 10, 20, 30 degrees and unlocked in an orthotic knee brace, and without a brace. The ground reaction force, knee joint angle and the knee flexion moment were measured using Qualisys Track Manager and Visual 3D Software. The extensor mechanism moment and the extensor mechanism force were calculated using static equilibrium equations and documented data. A one-way analysis of variance statistical test was performed to determine the statistical significance of the differences between the six types of immobilisation.
There was a direct relationship between the knee flex-ion angle and the extensor mechanism force. The extensor mechanism force at 0 degrees of immobilisation was significantly lower than that for 20 and 30 degrees (p< 0.05). The increase in the extensor mechanism moment arm with increasing knee flexion was not suf-ficient to offset the increase in the extensor mechanism force caused by the increase in the knee flexion moment. The results also showed that the knee flexion angle does not always correspond with the angle set at the knee brace; however they did exhibit a direct relationship.
These results have important implications for the management of patients with patella and extensor mechanism injuries. The results suggest that improvements in knee brace design to allow 0 degrees of knee flexion, rather than the 10 degrees as seen in this study, are likely to result in significantly reduced extensor mechanism tensile forces.
ABSTRACT WITHDRAWN
The protein Laminin-5 (L-5) is a ‘biological glue’, which is integral to epitheial cell adhesion. Covalently bonding L-5 to the ITAP titanium alloy (Ti6Al4V), may enhance the strength of the skin-ITAP interface.
Silanisation, a chemical technique that covalently bonds proteins to metals, could be used to bond L-5 to Ti6Al4V. We have assessed the characteristics L-5 silanised Ti6Al4V as a potential substrate for ITAP.
A small decrease in bound L-5 occurred after 24 hours of FCS soaking (p< 0.05), but subsequent to this no significant reduction was observed for 4 days (p< 0.05). Controls showed a significantly larger reduction after 24 hours (p< 0.05).
Fresh frozen femoral head (FFH) allograft is commonly used in impaction grafting for revision hip arthroplasty and long term success has been demonstrated by some groups. The optimum treatment of the graft prior to impaction has not yet been determined. Some groups wash the graft prior to impaction and others do not. Washing of the graft has been shown to improve bone ingrowth in a bone chamber animal model however the reasons for this remain unclear. The aim of this study was to identify any underlying cellular cytotoxicty of fresh frozen allograft bone before and after washing.
Samples of morcellised FFH allograft were taken during revision hip arthroplasties prior to impaction grafting. Paired samples, taken before and after washing were taken from each case. Washing was performed by 4 consecutive washes in 300ml warmed saline, the bone being filtered between each exchange of saline. Cytotox-icity was assessed for all samples using both contact and extract assays. Contact assays involved culture of cell lines in direct contact with bone samples. Extract assays utilised culture media conditioned with bone samples and subsequent quantitative assessment of cell metabolism and viability using both dimethylthiazol (MTT) and neutral red (NR) assays. All assays were performed using both human osteoblastic (MG63) and fibroblastic (HSF) cell lines.
Nine pairs of samples were analysed for cytotoxicity using both cell lines. Contact assays demonstrated a clear zone of cellular inhibition around the unwashed bone samples. Extract assays were performed in triplicate for each cell type and both MTT and NR assays giving 108 paired assay results. 88.9% of pairs (92/108) showed cytotoxicity in the unwashed sample. No washed samples demonstrated cytotoxicity. When grouped by assay and cell type, analysis of means showed statistically significant differences between washed and unwashed samples in MG63-NR (p=0.0025), HSF-NR (p=0.0004) and MG63-MTT (p=0.008). The difference observed in the HSF-MTT assays did not reach statistical signifi-cance (p=0.06).
In conclusion, we have shown that unwashed FFH allograft can be cytotoxic to human osteoblastic and fibroblastic cell lines in vitro. This suggests that allograft should be washed prior to impaction in order to optimise the biological compatibility.
Mechanical force is an osteoinductive factor that plays an important role in bone growth and repair in vivo (Carter et al. 1988). Many in vitro studies have shown that osteoblasts and osteocytes respond to mechanical loads such as stretch and fluid-flow induced shear stresses, with initiation of signalling pathways (Reilly et al 2003). The underlying mechanisms by which bone cells respond to mechanical signals are difficult to investigate in a 3-D environment, because of reduced nutrient delivery to cells and difficulties in analysis.
We are developing a model to analyse the effects of mechanical compression on matrix forming osteoblasts in a 3-D system. Our model uses polyurethane (PU) open cell foam scaffolds, MLO-A5 osteoblast-like cells (Kato et al 2001) and a sterile fluid filled biodynamic loading chamber (Bose). We have shown using a cell proliferation assay (Promega) that cells survive well and proliferate in the PU scaffolds. Cell number after 15 days of culture was four times that after 5 days of culture. To examine the effect of mechanical stimulation on osteoblastic cells we seeded MLO-A5, kindly donated by Dr. L. Bonewald, at densities of 125,000 cells per scaffold in PU foam cylinders, 10 mm thick and 25 mm diameter. The cell seeded PU scaffolds were dynamically loaded in compression at 1Hz, 5% strain in a sterile fluid-filled chamber. Loading was applied for 2 hours per day at days 5, 7 and 9 of culture. In between loading cycles, scaffolds were cultured in an incubator in standard conditions.
Preliminary data indicates that the cells survived loading but final cell number was reduced compared to unloaded controls by 30%. However, the scaffold stiffness (Young’s modulus) increased in loaded samples over time (days) which may be an indication of increased matrix production. Fluorescence microscopy indicated that loaded cells were distributed in dense clusters whereas unloaded cells were distributed evenly throughout the scaffold. In conclusion, this model has the potential to answer questions about cell survival, distribution and matrix production in 3-D, in response to mechanical signals.
The integration of mechanical stimulation in the tissue engineering process may lead to a progress in the structural and biomechanical properties of these tissues and offers new possibilities in the management of bone injuries and degenerative diseases.
Reamed, locked intramedullary nailing is the treatment of choice for many long bone fractures, be them open or closed injuries. Certain nails used can be inserted without any locking component or reaming. However, the most biomechanically sound fixation is achieved with a reamed, locked nail, and this therefore is the preferred construct. The process of reaming is not without complication, however. Pulmonary complications secondary to embolization of intramedullary contents are of the most concern. The formation of emboli is believed to be a direct result of raised intramedullary pressures created largely by the reaming process, although nail insertion does also play a part.
The magnitude of intramedullary pressures generated during the reaming process is due, in part, to the design of the reamer itself. This study compares four different reamers currently in use in NHS hospitals today. The reamersusedincludeanolderdesign(AOUniversal(TM)) and three newer designs (Synthes Synream(TM), Biomet 5+(TM) and Stryker Bixcut(TM)).
Four different reamer head sizes were used- 9.5mm, 11.5mm, 13.5mm and 15.0mm. These were tested in vitro using a Vaseline(TM)/paraffin oil mixture to simulate intramedullary tissue and Perspex(TM) tubing of varying sizes to simulate a long bone with an intramed-ullary cavity.
The results showed that the older generation reamer produced consistently higher pressures than the newer designs of reamer with statistical significance. All the newer generation reamers produced similar pressure magnitudes, although the Biomet 5+(TM) tended to produce the lowest pressures with some statistically sig-nificant differences.
This study shows that different designs of reamer can generate different pressures and that the newer generation of reamers do produce lower pressures. This is therefore important in the prevention of complications associated with reaming and intramedullary nailing.
Tendons and ligaments are similar in composition but differ in function. Simple anatomical definitions do not reflect the fact individual tendons and ligaments have unique properties due to their adaptation to a specific role. The patellar tendon is a structure of particular clinical interest. A null hypothesis was declared stating that the patellar tendon is not significantly different in terms of matrix composition and collagen fibril diameter to other tendons.
The lateral and medial collateral ligaments (LCL, MCL), anterior and posterior cruciate ligaments (ACL, PCL), together with the long digital extensor, superfi-cial digital extensor and patellar tendons (LDET, SDFT, PT) were harvested from 3 cadaveric ovine hindlimbs. The extracellular matrix was assessed in terms of water, collagen and total sulphated glycosaminoglycan (GAG) content. The organisation of the collagen component was determined by an ultrastructural analysis of collagen fibril diameter distributions using electron microscopy, together with values for the collagen fibril index (CFI) and mass-average diameter (MAD).
There were significant differences between ligaments and tendons. The PT had a bimodal collagen fibril diameter distribution with CFI72.9%, MAD 202nm, water content 53.1%, GAG content 2.3 g/mg and collagen content 73.7%, which was not significantly different from the other tendons.
The results of this study support the null hypothesis suggesting that the patellar tendon is similar to other tendons and demonstrate that tendons have different characteristics to ligaments.
Multiple biological and mechanical factors may be responsible for the failure of fixation in cemented total hip replacements (THRs). Although the eventual failure of THRs may appear to be biological, the initiation of the failure during early period post operation may well be mechanical. It is in this area that mechanistic analysis is of particular significance.
This study builds on work by Rapperport et al, Dals-tra and Huiskes on stress analysis of implanted acetabulum, while focuses on fracture mechanics analyses of fracture of cement and of bone-cement interface. Specifically, finite element models were developed where cracks of most favourable orientations in the cement mantle were simulated. Possible crack path selections were explored. A simplified multilayer experimental model was also developed to represent the implanted acetabulum, and fatigue tests were carried out on the model. The experimental results were compared with those from the FE model.
Furthermore, interfacial crack growth at bone-cement interface was simulated from the superior edge of the acetabulum, as suggested from the clinical observations. The strain energy release rates were computed for typical hip contact forces during gait and as a function of crack length. Associated phase angles were also computed to account for the materials mismatch. The results were evaluated against the interfacial fracture toughness of the bone-cement interface, measured using sandwich Brazilian disk specimens. The results show that although interfacial fracture seems to be unlikely for large phase angles where shear component is most active, the strain energy release rates are comparable with the values of the interfacial fracture toughness when mode I is predominant, suggesting interfacial fracture.
The study also shows that the fracture toughness of cement is much higher than the interfacial fracture toughness of bone-cement, this may explain the reason why interfacial fracture is favoured even if the crack driving force at bone-cement interface appears to be weaker than that in the cement mantle.
Two stainless steel ‘TriMed’ distal radial fracture reduction techniques were tested to compare the relative stability of the two in vitro for a pre-determined fracture pattern. The movement of the bony segments were plotted over time using an ARAMIS 3 dimensional non-contacting displacement mapping system (GOM mbH, Braunschweig, Germany) to give quantitative data. The data was used to calculate the relative motion of the bony segments with the aim of investigating regions of compression across the fracture line, which is thought to accelerate fracture healing, and shear between bony segments, which is detrimental to fracture healing.
Ten third generation adult radius biomechanical model Sawbones (Sawbones, Malmö, Sweden) were cut to simulate AO type C2 fractures with dorsal comminution. Five bones were plated using the TriMed fixed angle volar bearing plate and five were plated using the TriMed radius and ulnar plating technique. Samples were potted and loaded cyclically at 1 Hz via a floating scaphoid-lunate bearing onto the end of the radius at incrementally increasing loads of 100 N – 500 N with 1000 load cycles applied for each load level.
The results showed the radius and ulnar pin-plate configuration allowed greater movement of the articular surface, with relative shear motion and separation between the two segments, although the relative shear movement between the two distal segments was below 2mm, which is considered the definition of failed fixa-tion. With the volar bearing plate the two distal segments moved as single unit and compression with minimal shear was applied across the fracture line to the proximal radius. Thus the radius and ulnar plates allowed shear across all three fracture lines, while the volar plate held the two distal segments fixed relative to each other and allowed compression across the interface with the proximal radius. The ARAMIS system allowed the three dimensional motion of the bony segments to be followed, in particular the relative motion between the segments, indicating the type of healing to be expected clinically. The study demonstrated the value of ARAMIS in investigating the stability of wrist fractures fixations and can easily be adapted to investigate other orthopaedic fixation systems.
The aim of this study was to discover if the ulnar styloid is sufficiently consistent in size, shape and position relative to other bony features of the ulna to be used as a reference in pre-operative planning of fixation of broken bones.
The comparison of size and shape (together known as form) between bones has recently been facilitated thanks to the advance of technologies designed to allow the comparison of the form of structures using anatomical landmarks.
This new class of methods is collectively known as geometric morphometrics. It eliminates the differences in location and rotation of landmark through registration that minimises the sum of squared deviations from each other after scaling. This is Procrustes registration. The residual size and shape information is amenable to statistical analysis. In the present application, the registered Procrustes landmarks are used to compute a mean (reference) shape. The individuals are then compared to this mean/ reference shape. Using principal components analysis (PCA) variations in shape are not only identi-fied, but also quantified. The identification of patterns of deviation from the mean shape is considerably enhanced through the use of 3-D visualistaions of the shape variations represented by the space of the PCA.
These analyses indicate that the ulnar styloid is suf-ficiently consistent in location to other anatomical landmarks that it could be used as a radiographic marker in preoperative planning.
More importantly, the analysis of this study indicates that the methods of geometric morphometrics are widely applicable to the analysis of 3-D variations in morphology facilitating the analysis and comparison of radiographs. A useful future application will be in the development of 3-D reference morphologies that will allow the surgeon to compare and contrast the morphology of a radiograph of a badly broken (comminuted) bone to a standard one. Eventually computer might assist the surgeon by geometrically and visually showing how and by how much the bone needs reduction. Similarly, applications to the the virtual comparison of diseased and healthy bones might allow quantative and visual comparisons that could aid diagnosis and planning.
The pattern of injury to the carpal ligaments following wrist trauma is unclear. Different imaging techniques often prove inconclusive rendering the diagnosis difficult and hence the treatment controversial. This study aimed to observe and evaluate the differences in scapholunate kinematics before and after sectioning the scapholunate interosseous ligament (SLIL) and radioscaphocapitate ligament (RSC).
Twenty two embalmed cadaveric wrists were used. There were four males and seven females with an average age of 84 years. Their medical records confirmed the absence of previous history of wrist diseases or injuries. The extensor and flexors tendons of the wrist were removed leaving the capsule intact. Two drill bits (1.5 mm) were used to make a hole each in scaphoid and lunate, one centimeter apart. The drill bits were left in the bones to act as metal wires for calibration. Each wrist was moved through a set of motions and each movement was performed thrice; first one with the ligaments intact, second with SLIL sectioned and the last one with RSC excised. Digital photographs were taken and angles measured with MB Ruler software. Analysis of variance was done using SPSS 12.
There was no angle between the metal pointers when the ligaments were intact. There was movement and change in angle detected when SLIL and RSC were sectioned. The sectioning of the SLIL lead to a significant increase in the angle between the pointers in all the movements recorded (p value < 0.001). Subsequent sectioning of the RSC further increased this angle but this increase was much smaller compared to that after sectioning SLIL. On completion of the measurements the wrist capsule was opened to reveal that both the ligaments had been successfully sectioned and there were no degenerative changes in the bones or ligaments in any wrist.
This first cadaveric evaluation of alterations in scapholunate motion with sectioning of SLIL and RSC revealed that SLIL has a significant influence on the scapholunate kinematics, where as sectioning of the RSC has little additional effect. This in-vivo finding might have implications of importance of preserving SLIL during wrist surgeries and its role in management of carpal instabilities.
The data collected from both digitizing tools were merged into the same coordinate system and graphically represented. Paired Student’s t-tests were used to compare the inclination and retroversion angles for the two techniques.
Small deviations in the recovery of head orientation in shoulder arthroplasty may impact on the longevity of an implant. The differences in inclination and retroversion noted in this study may alter the load on the glenoid and/or rotator cuff mechanism in joint replacement. Further research is necessary.
Previous experimental studies of the pelvis have been carried out on cadaveric samples stripped of soft tissue. Investigations of the stress concentrations present in the pelvis due to the application of force through the hip joint have been conducted with the superior iliac crests cast in resin or cement. Thus stress concentrations are observed towards the superior iliac crests, and to some extent the pubic symphysis (these being the areas in which force transfer can occur). Due to the rigid fixing of the pelvis in these experiments, the pelvic bone has become viewed as a ‘sandwich beam’ acting between the sacro-iliac and the pubic joints. Numerical models employing similar fixed conditions have shown good agreement with the experimental studies.
However it is clear that these experiments, and the accompanying computational models are not representative of the in-vivo situation, in which the muscles and ligaments of the pelvis and hip joint provide resistance to movement, and in the case of muscles place additional forces on the pelvis, not addressed in the experimental studies. This study presents a finite element model of the pelvis in which novel techniques have been used to include the pelvic ligaments, and hip joint muscles using realistic attachment areas on the cortex, providing a more realistic comparison to the in-vivo environment. Joint interactions at the pubic symphysis and sacro-iliac joints are also simulated. A fixed boundary condition model is also presented for comparison.
The resulting stress concentrations in the pelvis for single leg stance observed in the in-vivo boundary condition model are dramatically different to those presented in studies in which the pelvis is rigidly fixed in place. The abductor muscles are seen to play a significant role in reducing stress concentrations towards the sacro-iliac joints and superior to the acetabulum, in comparison to fixed boundary condition analyses. Stress reductions away from the acetabulum are also observed in the underlying trabecular bone for the in-vivo boundary condition model. Similar stresses are observed within the acetabular region for the fixed, and in-vivo boundary condition models.
Malpositioning of the component of a total knee implant and malalignment of the leg is one of the significant factors for the outcome after Total Knee Arthroplasty.
Previous studies have shown that the use of a navigation system can improve these. This article presents the initial results of a prospective and non-randomised study describing navigated implantation in TKA with special reference to soft tissue balancing in knees with posttraumatic deformity. The secondary objective is to found out reproducibility of the software.
It has been mentioned in the literature that minor deviations in the insertion point of Intramedullary instrumentation during TKA may result in malalign-ment of several degrees [Nuno-Siebrecht 2000], which can be avoided with these soft ware.
The visco-elastic behaviour of acrylic bone cement is a key feature of cement-implant performance. The ability of the cement to creep in conjunction with a force-closed design of stem (collarless polished taper) affords protection of the vital bone-cement interface. Most surgeons in the UK use antibiotic-laden PMMA in primary total joint arthroplasty. In revision surgery the use of bespoke antibiotic-cement combinations is common.
The aim of this study was to elicit the effect of antibiotics upon the physical properties of bone cement.
The cements used were Palacos R40 and Palacos R with gentamicin. The antibiotics added included fucidin, erythromycin, teicoplanin and vancomycin in 500mg powder aliquots up to a maximum of 1g per 40 g mix.
All data were analysed using ANOVA with Bonfer-roni post-hoc test. Pearson’s correlation coefficient was used to investigate the association between physical factors (SPSS).
Following hip arthroplasty carried out using the Slooff-Ling impaction grafting technique micro-motion of the acetabular cup is frequently seen within the bone graft bed. In some cases this can lead to gross migration and rotation of the acetabular cup, resulting in failure of the arthroplasty. The movement of the cup is thought to be due to the irrecoverable deformation of bone graft under shear and compressive forces. Previous experimental studies have addressed ways in which the behaviour of the bone graft material may be improved, for example through washing and the use of improved particle size distribution. However there has been a limited amount of research carried out into assessing the behaviour of the acetabular construct in-vivo.
This study presents a 3D finite element model of the acetabular construct and hemi-pelvis following impaction grafting of a cavitory defect. A sophisticated elasto-plastic material model was developed based on research carried out by the group to describe the bone graft bed. The material model includes the non-linear stiffness response, as well as the shear and consolidation yield response of the graft. Loading associated with walking, sitting down, and standing up is applied to the model. Distinct patterns of migration and rotation are observed for the different activities. When compared in a pseudo-quantitative manner with clinical observations results were found to be similar. Walking is found to account for superior migration, and rotation in abduction of the acetabular cup, while sitting down and standing up are found to account for posterior migration, and lateral rotation. The developed 3D model can be used in the assessment of cup designs and fixation devices to reduce the rate of aseptic failure in the acetabular region.
In-vitro studies have shown that wear rates of the metal on metal (MOM) bearing hip prostheses decline once the bearing runs-in and the bearing subsequently enters a steady state wear phase. Baseline cobalt levels are thus expected to decline with time in patients. Several clinical studies have not found such a decline. Baseline cobalt levels are hence limited in their capacity to provide information on the wear performance of the bearing couple. We have demonstrated in a previous study that exercise causes a rise in plasma metal ion levels in patients with MOM bearing hip replacement. Would the exercise related cobalt rise be more sensitive to detect change in wear behaviour of the bearing couple? We tested the alternate hypothesis that exercise related rise in the plasma cobalt levels will correlate inversely with the duration of MOM implantation.
Sixteen patients with three different well functioning MOM bearing hip replacement [two types of resurfacing (BHR, Cormet) and Metasul] were included into the study. Patients were divided in to two groups based on time since implantation, an early group of mean 18 months and a late group of mean 57 months. Plasma levels of cobalt were measured before (baseline) and after 1 hour of maximal exercise (peak). The difference between baseline and peak for each patient provided the exercise related cobalt rise. A significant increase in plasma cobalt levels of 13% was noticed after the exercise (p < 0.005). Baseline Cobalt levels in the late group (53nmol/l) were higher than early group (44nmol/l) but the difference was not significant (p=0.45). However, the mean exercise related Cobalt rise levels was lower in late group (3.5nmol/l) than the early group (6.5nmol/l). This lower rise in cobalt level in the late group precisely reflects on the steady state wear as seen in in-vitro tests.
Baseline cobalt levels are limited in determining the in-vivo performance of the bearing couple. Exercise related rise in cobalt levels can differentiate the running in and steady state wear phases of metal on metal bearings and is thus a more accurate tool of assessing in-vivo wear performance of the bearing couple.
Intramedullary pressures were better in all zones, for all cement modes, with proximal occlusion. The highest pressures were seen with Palacos-R at 4 minutes 30 seconds with proximal thumb occlusion. Stem insertion into Palacos-R at 4 minutes or 4 minutes 30 seconds, gave higher pressures than Simplex-P, with or without any form of occlusion. With Simplex-P, intramedullary pressures were higher, with Collar rather than thumb occlusion.
This study assesses the functional in vivo kinematics of Advanced Medial Pivot (AMP) TKR and compares it to kinematics of the normal knee.
Dynamic assessment of the wrist motion and the specific angles are difficult using the conventional methods. We wanted to adapt and assess the repeatability of the Fas-trak system for continuous monitoring of three dimensional (3 D) wrist movements.
Twenty seven volunteers, aged 18 to 30 years were asked to perform predetermined tasks. The exclusion criteria were previous history of wrist trauma or joint disease. The transmitter was mounted on the dorsum of the forearm while the sensor was placed over the third metacarpal head. The protocol of three tasks was developed. Task 1 measured maximal flexion, extension, radial and ulnar deviation of the wrist. Task 2 involved picking up an object and moving it across a barrier. Task 3 involved the writing simulation. The comparison between the left and the right wrists indicated suitability of the system to be used on either of the limbs. Repeated measurements on the right wrist provided an assessment of repeatability of the Fastrak system.
The Fastrak system was successful in acquiring data in 3 D. The transmitter and the sensor were easy to attach and were of no discomfort to the subjects. As expected the maximum movement was noted in the flexion-extension plane. The total arc of movement in the flexion-extension plane was 127.1 degrees and 69.7 degrees in the radio-ulnar plane. There was no statistically signifi-cant difference between the movements in the left and the right wrists, even when the effect of dominance was considered. The lift and move task showed that most subjects utilised three-fourths of the total possible radio-ulnar movement, but only one-thirds of the total flexion and extension. The writing simulation revealed a substantial variability between subjects. The Fastrak system revealed variation up to 3 degrees in the means of range of movements, while measuring wrist movements.
The current study showed that the Fastrak system is a user-friendly and repeatable device, which could be used in everyday clinical use. It has the potential to be used for evaluation of the diseased wrist and the results of therapeutic interventions, operative or otherwise.
Micro level finite element models of bone have been extensively used in the literature to examine its mechanical behaviour and response to loads. Techniques used previously to create these models involved CT attenuations or images (e.g. micro-CT, MRI) of real bone samples. The computational models created using these methods could only represent the samples used in their construction and any possible variations due to factors such as anatomical site, sex, age or degree of osteopo-rosity cannot be included without additional sample collection and processing. This study considers the creation of virtual finite element models of trabecular bone, i.e. models that look like and mechanically behave like real trabecular bone, but are generated computationally.
The trabecular bone is anisotropic both in terms of its micro-architecture and its mechanical properties. Considerable research shows that the key determinants of the mechanical properties of bone are related to its micro-architecture. Previous studies have correlated the apparent level mechanical properties with bone mineral density (BMD), which has also been the principal means of diagnosis of osteoporosis. However, BMD alone is not sufficient to describe bone micro-architecture or its mechanical behaviour. This study uses a novel approach that employs BMD in conjunction with micro-architectural indices such as trabecular thickness, trabecular spacing and degree of anisotropy, to generate virtual micro-architectural finite element models. The approach permits generation of several models, with suitable porous structure, for the same or different levels of osteoporosity. A series of compression and shear tests are conducted, numerically, to evaluate the apparent level orthotropic elastic properties. These tests show that models generated using identical micro-architectural parameters have similar apparent level properties, thus validating this initial bone modelling algorithm. Numerical tests also clearly illustrate that poor trabecular connectivity leads to inferior mechanical behaviour even in cases where the BMD values are relatively high. The generated virtual models have a range of applications such as understanding the fracture behaviour of osteoporotic bone and examining the interaction between bone and implants.
We previously demonstrated that cartilaginous tissue was induced on a reamed acetabular articulation in an ovine hemiarthroplasty model with three different femoral head sizes. At maximum loading during stance phase, the acetabular peak stresses immediately after reaming could reach approximately 80 MPa under direct implant-bone contact with in-vitro measurements.
We aimed to establish finite element (FE) models of the ovine hip hemiarthroplasty which examine stress distribution on the reamed acetabula by three head sizes. We hypothesized that the stress distribution did not differ between different sizes when the joint is congruent and that the peak stresses in the acetabulum immediately after reaming occurred in the dorsal acetabulum.
Three two-dimensional FE models of ovine hip hemi-arthroplasty were built; each comprised a head component, 25, 28, and 32 mm in diameter, and an acetabular component. The acetabular geometry was acquired from an ovine acetabular histological section. The head was moved to partly intersect with the acetabulum representing the reaming procedure and a congruent contact was confirmed. Cortical bone and cancellous bone were modelled as linear elastic, with moduli of 20 and 1.2 GPa, respectively. Variable moduli were also assessed. The finest mesh for each model consisted of over 100,000 four-node quadrilateral elements. Loading conditions were chosen to represent peak hip joint force developed during the stance phase. Stress distribution in the acetabular area in contact with the head was plotted against the articulating arc length.
The results confirmed that the stress distribution between different prosthetic head sizes in a reamed hemiarthroplasty model did not change when the joint was congruent. The peak compressive stresses occurred in the dorsal acetabulum with the 32 mm model being the highest at approximately 69 MPa, the 28 mm model at 63 MPa, and the 25 mm model at 54 MPa. An increase in the cancellous modulus and a decrease in the cortical modulus increased the peak stresses in the dorsal acetabulum.
This presents an indicative study into the effect of prosthetic femoral head sizes on the stress distribution in the acetabulum. The idealized 2-D models showed reasonable agreement when compared quantitatively with the in vitro study.
Metal-on-metal hip resurfacing arthroplasty is a conservative procedure that is becoming an increasingly popular option for young arthritic patients most likely to undergo a secondary procedure in their lifetime. The stability of the acetabular component is of particular concern in these patients who show an increased risk of failure of the cemented acetabular cups in conventional total hip replacements. The purpose of this study was to examine the initial stability of a cementless interference press-fit acetabular cup used in hip resurfacing arthroplasty and implanted into ‘normal’ versus poor quality bone. Also examined was the effect of the press-fit procedure on the contact mechanics at the cup-bone interface and between the cup and femoral head.
A finite element (FE) model of the DUROM resurfacing (Zimmer GmbH) was created and implanted anatomically into the hip joint, which was loaded physiologically through muscle and subtrochanteric forces.
The FE models included: a line-to-line, 1mm and 2mm interference press-fit cup. Also considered were two FE models based on the 1mm press-fit cups, in which the material properties of the cancellous and cortical bone tissues were reduced by 2 and 4 times, to represent a reduction in bone quality as seen with age or disease.
Increasing the cup-bone interference resulted in a sig-nificant reduction in implant micromotion. All the pressfit models showed predicted cup-bone micromotion below 50 micrometers. This would ensure adequate initial stability and encourage secondary fixation through bone in-growth. The predicted acetabular stresses were found to increase with the amount of press-fit, however, there was no suggestion of a fracture. These stresses would further contribute to securing the cup.
Reducing the bone quality showed an increase in the predicted micromotion and increased bone strain. Micromotion was below 50 micrometers, but the predicted compressive bone stresses, necessary for additional implant fixation, was reduced. This implied that poor quality bone would provide unsuitable support medium for the implant. The bearing surface contact mechanics were little affected by the amount of pressfitting.
The long-term stability of total hip replacements (THRs) critically depends on the lasting integrity of the bond between the implant and the bone. Late failure in the absence of infection is known as ‘aseptic loosening’, a process characterised by the formation and progressive thickening of a continuous layer of fibrous tissue at the interface between the prosthesis and the bone. Aseptic loosening has been identified as the most common cause for long-term instability leading to the failure of ace-tabular cups. There is clearly a need to study the failure mechanisms in the acetabular fixation if the long-term stability of THR is to be significantly improved. The bonding strength in the presence of defects is measured using interfacial fracture toughness, and this information is not available currently.
In this work, interfacial fracture toughness of synthetic and bovine bone-cement interface has been studied using sandwiched Brazilian disk specimens. Experiments were carried out using a common bone cement, CMW, and polyurethane foam under selected loading angles from 0 to 25 degrees to achieve full loading conditions from tensile (mode I) to shear (mode II). Finite element analyses were carried out to obtain the solutions for strain energy release rate at a given phase angle (ratio of shear and tensile stress) associated with the experimental models. The effects of crack length on the measured interfacial fracture toughness were examined. Microscopic studies were also carried out to obtain the morphology of the fractured interfaces at selected loading angles.
The results show that both polyurethane foam and bovine cancellous bone seem to produce a similar type of interfacial failure of bone-cement interface, with cement pedicles being ‘pull-out’ of the pores of the foam/ bone. Damage sustained by the cement pedicles seems to increase progressively as the increase of shear loading component. The measured values of fracture toughness are a function of crack length and phase angle, and are comparable with those published in the literature on cortical bone and cement interface.
The implication of these results on the assessment of fixation in acetabular replacements is discussed, particularly in the light of results from bovine cancellous bone-cement interface.
Morsellised cortico-cancellous bone (MCB) is used extensively in impaction grafting procedures, such as the filling of cavitory defects on the femoral and acetabular sides during hip arthroplasty. Several experimental studies have attempted to describe the mechanical behaviour of MCB in compression and shear, and it has been found that it’s properties can be improved by washing and rigorous impaction at the time of surgery. However their focus has not been on the development of constitutive models that can be used in computational simulation.
The results of serial confined compaction tests are presented and used to develop constitutive models describing the non-linear elasto-plastic behaviour of MCB, as well as its time dependent visco-elastic behaviour. It is found that the elastic modulus, E of MCB increases linearly with applied pressure, p, with E achieving a value of around 30 MPa at a pressure of around 1 MPa. The plastic behaviour of MCB can be described using a Drucker Prager Cap yield criterion, capable of describing yielding of the graft in shear and compression. The time dependent visco-elastic behaviour of MCB can be accurately modelled using a spring and dashpot model that can be numerically expressed using a fourth order Prony series. The role of impaction in reducing subsequent plastic deformation was also investigated. The developed relationships allow the constitutive modelling of MCB in finite element simulations, for example of the acetabular construct following impaction grafting. The relationships also act as a gold standard against which to compare synthetic graft and graft extender materials.
Three methods to reattach avulsed finger flexor tendons to the distal phalanx were compared: a 1.8 mm metal barbed suture anchor, twin 1.3 mm PLA (polylactic acid)absorbable anchors, or a pull-out suture over a button. The suture-anchor interface was tested by pulling the suture at 0, 45, and 90 degrees to the anchor’s axis. The anchors were tested similarly in plastic foam bone substitute. Repairs of transected tendons in cadaveric fingers were loaded cyclically, then to failure. The suture failed prematurely if pulled across the axis of the anchor. Conversely, fixation in bone substitute was stronger when pulling at an angle from the axis. Cyclic loads caused significantly more gap formation in-vitro with twin 1.3 mm absorbable anchors than the other methods; this method was significantly weaker. The 1.8 mm anchor gave similar performance to the pull-out suture over button technique, while the twin 1.3 mm absorbable anchors were weaker and vulnerable to gap formation even with passive motion alone.
Retrieval studies based on revision operations at King Edwards VII Hospital reveal that, although micro-cracks develop in the cement mantle, it is the debonding between cement and bone that often defines the final failure of cemented acetabular replacements. This was illustrated at the revision surgeries by the easy removal of the acetabular cups with cement mostly attached to the cup. It is felt that a fundamental understanding of the mechanisms that initiate and propagate the interfacial failure at the bone-cement interface is the key towards solving the problem.
In this work, in-vitro fatigue tests were carried out on cemented acetabular replacements using third-generation of composite pelvic bones. Standard Charnley cups were implanted using common bone cement, CMW, following the standard surgical procedures. The implanted hemi-pelvic bone model was then constrained at the sacro-iliac and pubic joints to represent the anatomic constraint conditions. Cyclic loads representing the maximum range of the hip contact force during normal walking were used and the direction of the maximum hip contact force was achieved by using angled plates. In addition to standard cup position, open cup and retroverted cup positions were also examined to assess the significance of cup orientation under fatigue loading conditions.
Damage development in the reconstruction was monitored using CT scanning at regular intervals. Permanent records were collected and the sample was eventually sectioned and polished for microscopic studies. Results show excellent correlations between the results from the CT images and the microscopic studies, indicating progressive bone-cement interfacial failure in the posterior-superior quadrant.
The significance of the work in the studies of ‘aseptic loosening’ will be discussed.
The visco-elastic behaviour of cement, is a key feature of cement-implant performance in total hip arthroplasty.
The aim of this study was to describe the creep behaviour of the leading plain bone cements under standardised physiological in-vitro conditions.
The cements tested were Palacos R, CMW1 and Smartset GHV and Surgical Simplex P.
All data were analysed using ANOVA with Bonfer-roni post-hoc test (SPSS).
The intensification of free radical processes at total joint replacements is well known. Wear particle-induced inflammatory reaction and metal corrosion is associated with generation of the oxygen radicals. At the normal functioning of joint implants there is a natural deterioration and constant updating of their surfaces. In these conditions probably also formation of free radicals during tribochemical reactions.
The radical-generating ability of the wear particles of orthopaedic alloys, alumina ceramics and antioxidant properties of various cured cements and UHMWPE were studied using the model reaction of cumene oxidation. Artificial wear particles of different alloys and ceramics were obtained using dry friction of a ball against a disk made of appropriate materials. Cement powders were obtained by grinding cement samples in a ceramic mortar.
Wear particles of orthopaedic alloys were found to initiate cumene oxidation whereas ceramic particles were inert. It was revealed that cobalt-chromium-molybdenum particles were much more active than titanium-aluminum-vanadium and stainless steel particles. Different amounts of antioxidants (from 2.3 to 12 millimole/kg) were detected in cured cements which considerably exceeded their amounts in the initial liquid cement components. The content of antioxidants in cured ÑÌW-1 cement was 3-5 times more than that in Palacos P and Sulcem1 cements. The amount of anti-oxidants was considerably lower in UHMWPE than in the mentioned cements. The reactivity of combinations of different particles is determined by relative particles’ contributions, and such mixtures are able to demonstrate either antioxidative (alloy-cement mixture) or prooxidative (alloy-UHMWPE mixture) properties. In particular, cement particles suppressed cumene oxidation caused by cobalt alloy particles. Inhibition duration depends on the ratio between alloy and cement particles and on the content of antioxidants in cements. Polyeth-ylene particles were not able to inhibit cumene chain oxidation caused by cobalt alloy particles.
Investigation of prooxidant and antioxidant behavior of the wear particles of orthopaedic materials provides better insight into their action on surrounding tissues and implant components. In particular, it is necessary to develop methods of preclinical testing that can simulate and estimate the action of radical intermediates generated in the course of tribochemical reactions on implant components.
More than 100,000 anterior cruciate ligament reconstructions are performed annually in the USA. The hamstrings and the patellar tendons are the most frequently used graft tissues. Up to ten percent of these grafts are deemed to have failed, generating considerable discussion in the literature regarding the ideal graft choice. A three-dimensional computational model, taking into account both material and geometrical non-linearities, would be useful in predicting the performance of different graft tissues and fixations. Unfortunately, the mechanical characteristics and parameters needed for such a model are complex and largely unknown. The aim of this study is to develop a method for measuring the geometrical properties needed as input for a three-dimensional tendon model.
A laser-based, non-contact technique is used to generate a series of cross-sectional profiles along the length of the tendon. Unlike previously proposed methods, it is able to detect concavities and can be constructed using equipment commonly found in an engineering laboratory. A laser line generator (Stocker-Yale Lasiris SNF, Quebec, Canada) projects a horizontal line onto the sample. Images of the line are acquired with a digital video camera (Basler A631fc, Germany) as the tendon is rotated. These images are reassembled into 2-D slices using MatLab software. Multiple cross-sections can be combined to create three dimensional geometries.
The new method was validated on objects of known shape (circular and hexagonal cylinders). The cross-sectional area measurement was found to be accurate to within 2.5%. The method was repeatable to within 1.7%. Six bovine flexor tendons have been analysed; concavities were evident in four of these. This method could be adapted to determine the surface geometries of other long and slender objects.
Thermonecrosis either results in bone loss which may weaken the purchase of surgically-inserted screws leading to loosening or the dead bone may remain in situ and become infected resulting in a ring sequestrum. The aim of this project was to measure the heat generated during drilling of bone. By using a novel realtime thermal camera the thermal events could be visualised topographically.
An experimental setup comprising a force table, an infrared camera, a power drill and a new surgical 2.5mm drill bit was constructed. This enabled measurements of the force applied and temperature changes in sheep cortical bone during a drilling operation. The temperature was observed throughout the drilling period and for further 15s after the drill bit was withdrawn. Images were grabbed using a LAND FTI Mv thermal camera which was driven by LIPS Mini software. Calibration was made in the range 20-200 degrees C, the upper value being provided by a high wattage resistor. Data was processed using routines written in MATLAB.
It was found that 12s were required to drill through a single cortex. Within one second of drilling, the maximum recorded temperature in the vicinity of the drill increased from the baseline of 20 to 170 degrees C. It remained above this temperature for 25s. Immediately after the drill bit was withdrawn, a region of approximately 15mm of diameter of cortical surface had a sustained temperature above 50 degrees C. After 15s of cooling, this diameter had only reduced to 10mm. By modelling the cooling curve, the maximum temperature at the drill tip was extrapolated to be between 500-600 degrees C.
Thermography has proven to be useful in the study of the thermal characteristics of bone during drilling. The process of drilling generates significant increase in temperature in the vicinity of the drill. This temperature elevation has been found to be sustained for a significant period of time.
Restoration of the bone defects on the background of the purulent osteomyelitis process is one of most pressing problems in orthopedics. In the last few years the medical procedure was improved thanks to use of semi-synthetic or syntetic implantation biodegradable composite materials.
The object of the investigation is to study possibilities of use of fast-biodegradable implant LitAr (Russia) for filling infected bone defects in course of complex treating various osteomyelites forms.
The composite material LitAr (in plates) is a mixture of components: xenocollagen and hydroxoapatite. Material is intended for stimulating osteogenesis. In event of infection materials LitAr in 7-10 days is lysed by the wound and microbe ferments and cannot support purulent process. Composite material was introduced into osteomyelitis defect intraoperative through an open wound by introducing a dry substance through fistu-las as well as in form of a suspension in 0.9%-sodium chloride solution. For 13.6% of patients postoperative time period was complicated by suppuration of operative wound. It was stated in course of use of material LitAr that in spite of secondary wound suppuration active osteogenesis rate was little different from similar process for patients with wound healing by first intention. It made it possible to use material more active for patients of advanced years because it was impossible to use a radical sanitation of purulent bone cavity for these patients. Material LitAr was used for 13 patients with osteomyelitis cavities. In form of a suspension (injection-ally or through a fistular duct) in 0.9% NaCl solution material was introduced through fistulas for 8 patients with an affected shin bone. Roentgenological signs of consolidation emerged by 35-40 days. A complete ossi-fication set in by 95-120 days. Immobilization was performed by use of plaster. In far-off time periods (about 2 years) no pathologic fractures were noted. 2 patients had a relapse of fistulas formation (15.4%).
The use of implant LitAr for filling infected bone defects for stimulating osteogenesis and for restoring bone continuity in a complex treatment of various forms of osteomyelitis can be considered as an effective one including for patients because it was impossible to perform a radical sequestrectomy for these patients.
Chondrocyte density was calculated from a defined site in each joint.
Cartilage volume was measured by novel application of Peripheral Quantitative Computed Tomography (pQCT).
Cartilage oligomeric matrix protein (COMP), glycos-aminoglycans (GAG) and total protein (TP) concentrations were measured and then adjusted for cartilage and synovial fluid volume and compared between joints.
The DIP had higher TP, COMP and GAG concentrations, however, when values were expressed per unit cartilage volume the opposite was found, with the MCP then exhibiting significantly higher concentrations.
Older fracture patients frequently ask whether their osteoporosis will affect fracture healing. There is only limited previous data about this. We investigated recovery after distal radial fracture, and compared it with BMD of the other distal radius and the lumbar spine (measured using quantitative CT).
All 28 patients had sustained a dorsally displaced distal radial fracture which was deemed to require treatment by intrafocal wire fixation. All patients had acceptable correction of dorsal and radial angle at final x ray (3 months). Wrist function was measured using the Patient Rated Wrist Evaluation (PRWE – a validated outcome measure for use after distal radial fractures), grip strength,and range of motion. All measurements were made at 6, 12 and 26 weeks. BMD was measured in the opposite wrist and the lumbar spine using QCT at 6 weeks after fracture.
There was no correlation between recovery of grip strength (% of contralateral grip strength) at 6,12,or 26 weeks with BMD at either site. Similarly, there was no correlation between BMD and either absolute PRWE scores at any time point or improvement in PRWE between time points. The strongest predictor of recovery of grip appeared to be the proportion of grip recovered at 6 weeks (correlation between% grip recovered at 6 weeks and 3 months r = 0.85; at 6 weeks and 6 months r= 0.56; both p < 0.001). This was not affected by age or variations in measured final dorsal or radial angles or length within this group. It was not affected by degree of preoperative fracture displacement.
These data suggest that recovery of function after distal radial fractures is not influenced by osteoporosis. The data about the importance of initial recovery of grip suggest that factors other than bone position and bone healing may affect rate of functional recovery after distal radial fracture.
The Pipino prosthesis was introduced as an alternative to hip resurfacing because of its bone preserving capability. Preserving the femoral neck to a greater extent saves valuable bonestock for possible revision procedures. The stem (proximal 2/3) and acetabular cup are hydroxyapatite coated. Bearings were all either ceramic or metal on polyethylene. All procedures were performed or directly supervised by the senior author.
Patients in the cohort were assessed pre-operatively, in the short term and the medium term using the Harris Hip Score(HHS). Hip radiographs were performed at medium term follow-up to assess for radiological signs of aseptic loosening.
The study is based on a cohort of 70 patients, 34 male and 36 female with mean age of 52 (range 13-71). Followed up over a mean period of 43 months (range 17-60). 70 patients were contacted and 64 patients were reviewed. Four patients were lost to follow-up. Indications for surgery were Osteoarthritis (56); Rheumatoid arthritis (8); AVN (3); SUFE (2); Perthes (2); DDH (1); Psoriatic Arthropathy (1).
The cohort’s preoperative HHS showed a mean 50.1 (range 25-88). This increased to a mean of 95.9 (range 55-100) in the short term review period, during the medium term review the mean 93.6 (range 63-100). With 82% of patients in the excellent group and 88% good to excellent group.
At the final review there was one case of aseptic loosening (Cup) which required revision surgery. There were 2 dislocations and one intraoperative lateral femoral wall fracture and no cases of superficial or deep infection.
In conclusion we believe that the Pipino collum femo-ris preserving total hip arthroplasty has excellent short and medium term results.
Over 1 million fractures occur each year in the UK. Approximately 5-10% of these fractures have problems with healing. The treatments used for these patients often have a poor outcome and are associated with increased morbidity and disability. Application of synthetic peptides such as thrombin degradation peptide (TP508) has been shown to accelerate fracture repair in a closed rat femoral fracture model. Controlled release of TP508 using microspheres has been shown to enhance repair of articular cartilage defects and stimulate bone formation in segmental defects in rabbits. The aim of this study was to determine whether TP508 could bring about healing in an established fracture non-union model.
A validated rat model of fracture non-union was used. The model was created and left for 8 weeks in order to represent a clinically equivalent model of a non union of a fracture. Rats were randomised into two treatment groups receiving 10microg and 1microg doses of TP508 diluted in 50microL of microspheres and delivered directly to the non union site using percutaneous injection 8 weeks after surgery. The control group received no treatment. At 16 weeks post-surgery, osseous bridging was assessed both radiographically and histologically.
Radiographically there was no difference between the control and two treatment groups. However, histomor-phometric analysis demonstrated that bone formation increased by 43.9% in animals that received high dose of TP508 compared to the control animals. The analysis also indicated that administration of the low dose of TP508 increased the amount of bone formation compared to the control by 9.9 %.
Administration of TP508 has been shown to enhance healing of segmental defects in both critically and noncritically sized defects. However, in our model which is an established fracture non-union model, TP508 did not manage to achieve full osseous union. It has been suggested that the action of this peptide is concentration and environment dependent possibly indicating that TP508 might be less effective when administered in a chronic situation such as that associated with the established non-union fracture. However, even in this sub-optimal situation an increased amount of bone formation was observed.
50 patients satisfied the inclusion criteria. There were 41 males and 9 females in ages ranging from 17 to 51 (mean 30.6 years), with no significant difference in age between sexes. Hamstring grafts were used in 29 knees and Bone-Patellar tendon – Bone (BPTB) grafts in 21. Knee laxity was measured using the Rolimeter with IKDC knee examination and functional assessments using the Lysholm, IKDC and KOOS scoring systems.
To explore the relationship of hyaluronan level in synovial fluid of the knee with the degree of synovitis and cartilage injury.
A total of 104 knees in 102 patients with knee osteoarthritis or other knee diseases was studied. The hyaluronan level in the synovial fluid of the knees was measured with enzyme linked immunoassay. The pathology of the synovium and articular cartilage was evaluated with Ayral’s score system and Outerbridge’s score system under arthroscopy. The data were analyzed by t’-test or nonparametric test, ANOVA, Pearson or Spearman correlation and multiple liner regression.
The results showed that the hyaluronan level in the synovial fluid of the knees was correlated positively with Ayral’s score (beta’A=0.497, P< 0.001) and negatively with accumulative Outerbridge’s score (beta’O=-0.364, P< 0.001), especially Ayral’s synovitis score in 104 cases. The hyaluronan level in the synovial fluid of the knees was higher in those with Ayral’s score > and = 60 than in those with the score< 60 (P< 0.001). The hyaluronan level in the synovial fluid of the knees was lower in those with accumulative Outerbridge’s score > and = 10 than in those with the score < 10 (P< 0.05). The level of hyaluro-nan in the synovial fluid in the knees with Ayral’s score > and = 60 was correlated negatively with accumulative Outerbridge’s score (beta’O=-0.437, P< 0.001) and positively with Ayral’s score (beta’A=0.339, P< 0.01), especially accumulative Outerbridge’s score.
Compared with other knee diseases, the hyaluronan level of OA knees was lower (P< 0.05). However, Ayral’s score and accumulative Outerbridge’s score were higher in OA knees (P< 0.001).
The hyaluronan level in the synovial fluid of the knee can reflect the degree of synovitis and accumulative cartilage injury, especially synovitis. It reflects the degree of accumulative cartilage injury mainly when synovitis is more severe. The decrease of the hyaluronan level in the synovial fluid of OA knee is results of integrating effect of the synovitis and cartilage injury.
The aim of this study was to determine if the exposure to patient and surgeon was decreased with use of the mini C arm.
ABSTRACT WITHDRAWN
Restoration of normal anatomy following a distal radial fracture is an important factor in determining functional recovery. However, current methods of assessing dorsal tilt and displacement require ‘true’ lateral radiographs, and important reference points are often obscured by metalwork.
22 patients with displaced distal radial fractures treated by ORIF, were included. Patients had pre and postoperative radiographs taken of the injured and uninjured wrists. From lateral radiographs, measurements were performed using the PACS system. A line was superimposed upon the dorsal radial cortex 2cm proximal to the wrist passing distally. The following measurements were performed: lunate height, distance from the ‘line’ to the superior and inferior poles of the lunate, and conventional measurements of dorsal tilt and angulation.
Our study suggests that there is a strong relationship between the distal radius and the lunate that could be used to assess fracture displacement and quality of reduction. Its main advantages are simplicity and ease of use despite the presence of metalwork.
Task presented here, (one of 5) performed by turning a key 90 degrees clockwise. Principal component analysis (PCA) was applied to the waveforms of group A, using the procedure illustrated by Deluzio et al.,1997 for use with walking gait patterns. A 90% trace criterion was used to calculate the number of principal components (PCs) to retain.
Intra-articular steroid injection has been widely used for relief of pain in Osteoarthritis. Recent studies show an increasing rate of infection in these patients following hip arthroplasty. We have reviewed our cohort of patients to see if they are susceptible to higher infection rate.
We reviewed a cohort of 167 consecutive hips that had at least one injection with a 40mg triamcinolone acetonide and 4ml 0.5% bupivacaine mixture to relieve the symptoms of hip osteoarthritis or to clarify a diagnosis of hip arthritis between January 1997 and Novem-ber 2004 were reviewed. A total of 37 hips (36 patients) that subsequently proceeded to have a total hip arthroplasty were selected as our study group. There was a minimum of a one-year follow up.
The rate of infection in our initial cohort of patients following a hip injection was 0.60% (1 hip) which resulted in repeated washouts and a subsequent total hip arthroplasty with a good outcome. On review of the 37 hips, one was revised due to a deep infection secondary to staphylococcus epidermidis. Four were revised for continued instability and pain with no evidence of infection either prior to or during revision. When deep infection is taken as an endpoint, cumulative survival at 7.5 years is 0.968 (95% confidence interval of 1 to 0.905). The total survivorship of this cohort if all revisions are included is 0.852 at 7.5 years (95% confidence interval of 0.730 to 0.974). The revision rate due to a deep infection in our study is 2.7%.
We conclude that patients who have a total hip arthroplasty after a hip injection do not have an adversely high rate of deep infection.
The Trent arthroplasty register reported that results of Hip arthroplasty in general setup were less than that reported from specialist centres by 5%. This independent prospective study tests the hypothesis that results of Birmingham Hip Resurfacing (BHR) arthroplasty from pioneering centres would not accurately represent the outcome of hip resurfacing when performed in general setup.
All patients were prospectively followed for at least five years at Oswestry Hip outcome centre. The surgeons carrying out the operation prospectively provided surgical details and thereafter patients were followed using Oswestry hip questionnaire (OSHIP) at fixed intervals. Survival was assessed by Kaplan-Meier method. Results were compared to the published results of BHR from specialist centres.
There were 679 patients, and 58 surgeons in the study. Mean age at operation was 51 years and mean follow up was 5.63 years. The predominant preopera-tive diagnosis was Osteoarthritis. Mean OSHIP score was 89.5. There were 29 (4.2%) failures mostly due to fracture neck of femur (34%). Out of 14 failures in the first year, 9 (64%) were due to fracture neck of femur. The Kaplan-Meier survival up to eight years is 95.354% in the current study.
Compared to the published results, there were 2 to 19 times high failure rate which is significantly higher (p=0.001) than the published studies. Most of the early failures were due to fracture neck of femur in the first year. Hence we prove our hypothesis, as the results of BHR from specialist centres do not accurately reflect on the outcome in general setup. The discrepancy in the results is mostly due to fracture neck of femur in the early postoperative time. The results of this study will enhance awareness of the early trend in failures. Appropriate patient selection and meticulous surgical technique will help avoid this complication in the general setup, where most of the patients get benefited from BHR arthroplasty.
Among the hypokalemic group the mean preopera-tive potassium was 3.69mmol/l and the mean postoperative potassium was 3.19mmol/l. The t-test showed a statistically significant difference between mean pre and postoperative potassium levels (P< 0.0001). High association was found with hypokalemia and post-operative dextrose infusion (38%). 50% of patients on diuretics developed hypokalemia post operatively. Interestingly, only 18% of these were hypokalemic pre operatively.
In patients with multiple medical problems, like diabetes, hypertension and CVA, high incidence of hypokalemia was found. (38% had 2 or more medical problems).
No significance in the mortality rate was found in fracture neck of femur patients with and without postoperative hypokalemia (40% vs. 39% at 3yrs).
The authors report the use of a modified ‘Y-V’ medial capsular repair in association with Scarf osteotomy for Hallux valgus in 55 patients (62 feet) aged 18 to 61 years (mean 43 years) between July 2004 and July 2005. All patients were followed up for minimum 6 months by questionnaire, physical examination (American Orthopaedic Foot and Ankle Society score) and comparison of preoperative and post operative x rays.
Using this technique none of the patients required an additional proximal phalangeal osteotomy (Akin Oste-otomy). At six months follow up American Orthopaedic Foot and Ankle Society score improved from 46 to 87. Intermetatarsal (IM) angle and the hallux valgus (HV) angle improved from 16 degree to 9 degree and from 31 degree to 16 degrees respectively (p less than 0.05).
Of the sixty two procedures 59 did not develop any complications. Two had superficial infections which required oral antibiotics only. One partial loss of correction of hallux valgus occurred for which the patient refused a second operation. Seven cases had some residual pronation deformity of the big toe identified by the patients who felt the deformity was ‘about 50%’ compared to before the operation.
Akins osteotomy achieves an apparent correction of hallux valgus without addressing subluxation of meta-tarso-phalangeal joint. Our technique reduces the meta-tarso-phalangeal joint and corrects the hallux valgus angle anatomically.
We recommend the use of this modified ‘Y-V’ medial capsular repair to correct the hallux valgus angle and reduce the need for an additional procedure to augment the correction achieved during Scarf osteotomy for hallux valgus.
With the increasing availability of magnetic resonance imaging, there is potentially less emphasis being placed on making a definitive clinical diagnosis. Changes in the undergraduate curriculum have also reduced the emphasis on orthopaedic clinical evaluation. This aim of this study was to evaluate the predictability of clinical examination alone in comparison with arthroscopic findings in 50 consecutive patients presenting for arthroscopy to our service. Four trainees examined each patient; each examiner was blinded to the clinical diagnosis made by their colleagues. All patients were examined in the ward and subsequently underwent examination under anaesthesia and arthroscopy.
Of the tests for meniscal injuries joint line tenderness was the most sensitive (77%) and specific (68%). Apley’s and McMurray’s test while specific (92%, 98%) lacked sensitivity (9%, 30%). Overall the tests for anterior cruciate ligament (ACL) disruption were more reliable than the tests for meniscal injuries. The anterior drawer and Lachmann tests had high specificity (90%, 75%) and sensitivity. The pivot shift test also had very high specificity (75%) and sensitivity (98%) for detecting ACL injuries. These data demonstrate that joint line tenderness is the most reliable sign of menis-cal injury. In the absence of joint line tenderness Apley & McMurray’s tests have little role in routine clinical examination. Clinical tests and signs of ACL deficiency are consistently reliable in diagnosing ACL rupture.
The purpose of this study was to review the early results of a consecutive series of patients undergoing periac-etabular osteotomy (PAO) at Cappagh National Orthopaedic Hospital. The procedure was first carried out in 1998, and a total of 85 PAOs have been performed in 79 patients. The mean follow-up was 42 months (range 6-84 months). There were 72 females and 7 males with a mean age at the time of the operation of 22.9 years (range, 14-41 years). The preoperative diagnosis was developmental hip dysplasia in 80 hips, Legg-Calve-Perthes disease in one hip, congenital coxa vara in three hips, and slipped capital femoral epiphysis in one hip. The average Merle d’Aubigne score increased from 12.4 points preoperatively to 16 points at latest followup. The lateral center edge angle of Wiberg was between – 20 and +28 before surgery and was improved from 12 to 48 (average 30 degrees) following PAO. While, the anterior center edge angle of Lequesne and de Seze was between – 22 and +35 preoperatively and was improved by an average of 28 degrees (range, 17 – 40) postoperatively. The acetabular index angle decreased from an average of 24.8 preoperatively to 8.4 postoperatively. Clinical follow-up revealed that 77% of patients had no or mild pain, 33% of patients had a limp and 64% of patients were unlimited in physical activity, representing a markedly improved clinical outcome. Four patients underwent subsequent total hip arthroplasty. The short term results in this group of patients treated with PAO show reliable radiographic correction of deformity and improved clinical scores. The study reflects the learning curve associated with performing this procedure and the results that can be expected with a smaller clinical case-load than described in previous studies. We suggest that PAO may safely be carried out at a non-super-specialized institution provided the surgeons have sufficient experience and patients are selected appropriately.
Many osteoporosis units are now identifying low impact fracture patients at presentation and assessing them for osteoporosis risk using a nurse led fracture liaison service (FLS); we established such a service in July 2002. Unfortunately many patients previously admitted with hip fractures have never been assessed, but are at high risk of future fracture. Outlined below is an audit of case finding using the theatre database to identify these patients.
All fractured neck of femur cases from 1999 to 2002 were identified on a theatre excel database. We utilised our Hospital Information Services System (HISS) to exclude those who had subsequently died. Current address and other personal/GP details were also found using HISS. Patients under 80 years of age received a questionnaire on osteoporosis risk factors, treatment and subsequent fractures and were invited for a Dexa scan.
Although this is quite a labour intensive intervention, it did identify many untreated osteoporotic patients who were a high risk of future fracture. It also highlighted the small number of patients who are referred for Dexa or commenced on treatment by their GP following the fragility fracture. We would recommend this strategy to other units for case finding. This emphasizes the importance of a FLS and the need to have active ways to implement NICE guidance.
The Ilizarov frame is a circular external fixator, invented by Professor Ilizarov in Siberia during the 1950’s. It uses the principle of distraction osteogenesis to form new bone in a variety of clinical situations where bone lengthening or realignment is needed. The Ilizarov frame began to be used in western medicine during the 1980’s and by 1993 over 6000 cases had been performed in Europe.
Plain x-ray is one of the methods used to monitor the progress of patients fitted with an ilizarov frame.
The aim of this study is establish a pattern of healing over time in patients with the Ilizarov frame using plain x-ray films. This will improve understanding of the procedure, aid clinicians in deciding when frame removal is appropriate and provide a method of early detection should healing not be progressing appropriately.
This is a retrospective study looking at a series of 58 digitised anterior-posterior x-ray films of the tibia and fibula, taken at set time points post-operatively, from 17 patients fitted with an ilizarov frame (19 separate legs with ilizarov frames in total). Image J, an image analysis system, was used to measure pixel density from vertical slices down the centre of each fracture gap and at set intervals horizontally across the fracture gap. A mean pixel density value for each fracture gap was also calculated. The x-rays were standardised using a standard step wedge.
Promising preliminary results show pixel density to be greater towards the medial aspect of the tibia, but this difference in pixel value decreases with time. This suggests that calcification of the new bone occurs medially to laterally across the tibia. Full results will be available in April and aim to build a picture of the fracture gap at set time points post-operatively, showing a pattern of calcification in patients with the Ilizarov frame that will become a useful clinical tool for deciding time of frame removal as well as affording early knowledge of problems with the healing process.
The growing interest in the development of spinal implants has led to an increasing need for biomechanical studies. Porcine spines are commonly used in such studies. Quantitative data of the normal porcine tho-racolumbar spine is lacking, yet these data are crucial to discussion of such studies. In this study we aim to provide such a database to highlight the differences between the porcine and human specimen with a view to help plan future studies contemplating their use.
6 adult (18-24 month old, 60-80 kilograms) male porcine spines were dissected of soft tissue. The lowest thoracic and all the lumbar vertebrae were studied (n=42). 15 anatomical parameters from each vertebra were measured by 2 independent observers using digital calipers (Draper PVC150D, accuracy ± 0.03mm). The mean, SD and SEM were calculated using Micro-soft Excel. Results were compared with available data on human vertebra (Zindrick et al 1987;Panjabi et al 1991,1992; Kumar et al 2000).
The inter class correlation coefficient for the observers was 0.997. The intra-observer agreement was statistically robust (0.994). The vertebral body height of the porcine vertebra was larger while both the upper and lower endplate depth and width were smaller than the human specimens. The pedicle width and depth was greater than the human specimen. The spinal canal length and depth of the porcine spine were smaller than humans indicating a narrow spinal canal. The spinous process length showed an increase from T16 to L1. This was in contrast to human spinous process. The results for the measured parameters and their comparison to human specimen will be presented.
Results from our study provides a database of anatomical measurements for the porcine vertebrae and highlights the differences with the human specimen. The data would help design future studies contemplating the use of pig spines. Biomechanical studies involving interbody cages, disc replacements and pedicle screw systems should take into account the differences and match implant size accordingly. It also provides valuable information for geometric and Finite Element Modelling of the porcine spine. Further, the results are useful in extrapolation of data from experiments which have used the porcine model.
The aim of the study was to measure the Quality of Life of young patients sustained fracture neck of femur.
This is a retrospective study of 50 patients who suffered different types of hip fractures. 67 patients underwent surgeries for hip fractures between 1998-2002 were sent the ‘EUROQOL EQ-5D’ questionnaire, out of which 50 replied back. Different parameters of EQ-5D including mobility, self-care, usual activities, pain / discomfort, anxiety / depression and the overall health status were graded by these patients. The overall scores were calculated. We compared those values with calculated EQ-5D values of control groups of the same age from the general population of the UK. Information about The type of fractures, the type of operation, complications, and the mechanism of injury were recorded and their effect on the quality of life was correlated.
Out of 50 patients, there were 29 male and 21 female, with a mean age of 48.52 yrs (16 to 60 yrs). There were 32 patients with intra-capsular neck of femur fractures, (16 undisplaced & 16 displaced) 17 intertrochanteric and one with a subtrochanteric extension. 16 patients underwent Internal fixation (AO Screws), 15 had a hemiarthroplasty, 18 had Dynamic hip screws and 1 had THR. The mean hospital stay was 7.14 days (3 to 28 days). 70% of the patients reported some problems with mobility, 44% had problems in self-care, 58% had a restriction of their usual activities, and 70% had pain & discomfort at an average of 4 years of follow up. When compared with same age groups from the general population there was statistically significant difference in the EQ-5D index and EQ-5D state with p value of [p=< . 05] in the patient aged between 30 and 60 and no statistical differences between the EQ-5D index or EQ-5D state in the age groups between 20 and 39. We also found an association between poor life quality and development of complications.
Complications included one dislocated hemiarhtro-plasty, one patient had AO screws removed.
Femoral head allograft bone used in complex orthopaedic surgery may transmit infection from donor to recipient. In order to minimise the risk all donors are serologically screened for Hepatitis B and C, HIV, HTLV, and syphilis at the time of donation and again at 6 months post-donation. Culture swabs are taken from the acetabulum and femoral head for 48 hour anaerobic and aerobic culture, and a sample of bone is incubated for 5 days in enrichment broth culture.
We have audited the culture results and screening tests performed in our bone bank from 2000 to 2005 inclusive.
1,528 allografts were received of which we had to discard 52 (3.4%) because of either positive cultures or serology. The vast majority of the positive cultures were due to S. epidermidis (30/43). All cultures were bacteria one might expect to find as normal skin flora. 3 patients had positive hepatitis C serology and 6 were syphilis EIA positive.
In May 2004 we decided in line with National Transfusion Guidelines for blood donation, to exclude donors who had had a blood transfusion since 1980 to mini-mise the risk of transmission of CJD. This and the opening of an Independent Treatment Centre (ITC) in our area drastically limited the number of possible donors to our bone bank. There was a significant reduction in the number of femoral heads received in 2004 and 2005 when compared with years 2000-2003 (p = < 0.00001).
We conclude that negligible numbers of femoral head allografts are lost due to our serological and microbio-logical screening tests. However measures introduced to limit the theoretical transmission of CJD via a bone allograft and the opening of a local ITC have had a huge impact on the number of potential donors available to us. To date the CJD prion has not been isolated from bone, but there have been 3 reported cases of transmission of infection by blood transfusion. We fear that the imminent introduction of a serological test for CJD will limit the number of possible bone donors even further.
The purpose of this study was to assess shoulder function after breast reconstruction surgery using latissimus dorsi flap.
Sixty-eight patients (72 breasts) had this operation. Average follow up was 38 months (range 24 to 54 months). DASH and Constant-Murley were used for clinical assessment. Twenty-nine shoulders found to have a normal function; whereas, 11 shoulders had mild disability, 10 shoulders had moderate disability and 8 shoulders had severe disability. However, only 6 patients reported being unsatisfied with their outcome. Furthermore, all these 6 patients were not satisfied with their breast reconstruction outcome.
This study confirms that following breast reconstruction surgery using latissimus dorsi flap, there is a considerable deterioration of shoulder function of varying degrees. Nevertheless, shoulder function is not the main concern of this group of patients.
A higher pre-operative Hb did not reduce the required duration of in-patient physiotherapy (p=0.72). There was no correlation between post-operative Hb and POMS (p=0.21) or required duration of in-patient physiotherapy (p=0.20).
A higher pre-operative grip strength predicted an early date of discharge by the physiotherapists (p=0.02).
In the pubertal growth plate, sex hormones play important roles for the regulation of the proliferation, differentiation, maturation and programmed death of chondrocytes. Many studies have been reported on the regulation of oestrogen in long bone growth, however, some of the mechanisms have remained unclarified to date including its role for cell kinetics in the growth plate chondrocytes. The aim of this study was to clarify the effect of the deficiency of oestrogen on growth plate chondrocytes.
We obtained the growth plates of femoral head from the normal and ovariectomized Japanese white rabbits at 10, 15, 20 and 25 weeks. Ovariectomy was performed at 8 weeks. The cell kinetics of chondrocytes as defined by the numbers of proliferating and programmed dying cells was investigated using immunohistological methods.
The lengths of the femur were almost same both in the ovariectomised and normal rabbits. The height of the growth plate was larger in the former. The total number of chondrocytes in the ovariectomised rabbits was less than that of normal rabbits of the same age. Immunostaining of proliferating cell nucleous antigen (PCNA) showed a decrease number of proliferating chondrocytes and that of caspase-3 indicated a little increased number of apoptotic chondrocytes.
Oestrogen regulates endochondral bone formation through several pathways. It directly binds oestrogen receptor alpha and beta, and the former accelerates longitudinal bone growth whereas the latter represses it. Another pathway is through the GH-IGF-I axis: it closely interacts with GH and IGF-I for the control of longitudinal bone growth. In addition, there might be other mediators including transforming growth factor-beta, other IGFs and still unknown paracrine or auto-crine factors as IHH PTHrP. Our study suggests that in the rabbit growth plate during puberty, oestrogen mainly acts through the GH-IGF-I axis since its defi-ciency declined the proliferating ability of chondrocytes, which led the decrease of the number of chondrocytes.
Measurement of the rate of fracture healing is a major problem in fracture research. Bone mineral density (BMD) of fracture callus has been used as a measure of healing in diaphyseal fractures. However, metaphyseal fractures (especially in the elderly) are now the commonest type of fracture and are a significant public health problem. This study investigated whether measurement of BMD at the fracture site in the distal radius can be used as a measure of fracture healing.
We recruited 28 patients who had sustained a dorsally displaced distal radial fracture which was deemed to require treatment by intrafocal wire fixation. All patients had acceptable correction of dorsal and radial angle at final x ray (3 months). Wrist function was measured using the Patient Rated Wrist Evaluation (PRWE – a validated outcome measure for use after distal radial fractures), grip strength,and range of motion. All measurements were made at 6, 12 and 26 weeks. BMD was measured at the fracture site (examining the BMD of the medullary bone at the fracture site after removal of wires), in the opposite wrist and the lumbar spine using QCT at 6 weeks after fracture.
There was no correlation between fracture site BMD and BMD at the other wrist or the lumbar spine (r < 0.3). The BMD at the fracture site was higher than the BMD at the other wrist (mean 168 vs 70 HU; p< 0.001 paired T test). There was no relationship between fracture site BMD or the ratio of BMDs fracture site / normal wrist, and any of the functional assessments (proportion grip strength recovered, range of motion or PRWE (r < 0.3)).
15 of these patients underwent a second QCT at 12 weeks after fracture. There was no significant change in fracture site BMD between the first and second scan.
These data indicate that fracture site BMD is unlikely to be a useful method of measuring metaphyseal bone healing. The increase in BMD at the fracture site was unexpected; possible explanations include impaction of bone or high BMD in woven bone (the relationship of which to bone stiffness is uncertain).
the influence of histology on durability of cartilage repair following collagen-covered autologous chon-drocyte implantation (ACI-C) in the knee. the relationship between macroscopic grading and durability of cartilage repair; and the relationship between macroscopic appearance and histology of repair tissue.
There was no correlation between the ICRS grading and MCRS either at one year (p=0.12) or at the latest follow-up (p=0.16). Also, the ICRS grading of the repair tissue did not correlate with its histological type (p=0.12).
Apoptosis of articular chondrocytes may play an important role in the pathogenesis of osteoarthritis (OA). The aim of this study was to investigate the incidence of chondrocyte apoptosis in equine articular cartilage (AC) specimens and examine the relationship between the process of cell death and the degree of cartilage degradation.
The study comprised 2 populations of equine cartilage taken from the left forelimb. Population 1 (n=10) consisted of full depth cartilage from weight-bearing regions of equine metacarpophalangeal (MCP), proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints. Population 2 (n=9) comprised cartilage from 6 different regions of the MCP joint: dorsomedial, dorsolateral, centromedial, centrolateral, palmarome-dial and palmarolateral areas. Cartilage from each horse for each of the joints and joint regions was not always available. Seven micrometre cryostat sections were obtained. Haematoxylin and Eosin with Safranin-O stained sections were used to score structural differences between samples for features of cartilage pathology using a ‘modified’ Mankin scoring system. Two methods were used to quantify apoptotic chondrocytes: a direct method in which chondrocytes were assessed for morphological features of apoptosis using a light microscope and an immunohistochemical staining technique to detect the expression of active caspase-3 using a commercially available monoclonal antibody.
Apoptosis assessed by the direct method did not show any association with increasing severity of OA (r=0.11, p=0.7205). Overall there was a positive correlation between caspase-3 expression and cartilage damage (r= 0.44, p=0.0043). Caspase-3 expression was found to increase linearly with increasing severity of OA in the superficial, middle and deep zones of AC (r=0.36, p=0.0198; r=0.49, p=0.0011 and r=0.37, p=0.0237 respectively). Moreover, caspase-3 expression was higher in the superficial and middle zones than in the deep zone (p< 0.001). In the superficial, middle and deep zones the expression of caspase-3 was higher in the MCP joint than the PIP joint (p< 0.05, p< 0.01 and p< 0.05 respectively).
The significant positive correlation between disease severity and chondrocyte apoptosis, suggests that this process plays an important role in the pathogenesis of OA. The differences in the extent of apoptosis observed in different joints could be explained by the biomechanical environment of the joints.
Antero-medial osteoarthritis of the knee displays a well recognised pattern of cartilage damage on the medial tibial plateau. Anteriorly there is a full thickness cartilage defect, with transition to a partial thickness defect, becoming full thickness in the posterior third of the plateau. The retained posterior cartilage is macroscopically normal, but no previous study has assessed its histo-logical features. This study characterises the histological changes, to examine if antero-medial OA of the knee represents a model of progressive osteoarthritic cartilage damage.
Five unicompartmental resection specimens of patients with idiopathic single compartment antero-medial osteoarthritis were assessed. The samples were stained with H& E and Saffinin-O stains and reviewed using the Mankin system, an established method for scoring osteoarthritic changes in cartilage (range 0 [normal] to 14 [grossly osteoarthritic]) Digital images of the histology were reviewed by two observers to exclude inter and intra observer error. Each specimen was assessed at 4 interval points (A,B,C,D) along the A-P axis starting from the most posterior aspect of the exposed bone to the area of macroscopically normal cartilage. Three repeat measurements were taken from the macroscopically normal region (D1,D2,D3). The scores were compared to historical age matched controls of non-osteoarthritic cartilage, where a Mankin grade of < 3 suggests normal cartilage.
From anterior to posterior the H& E staining showed a consistent decrease in structural integrity and cellularity of the cartilage, matched by a qualitative decrease in GAG content (Saffinin-O staining). Mean Mankin scores showed a progressive decrease in score; A = 14.0 (95% CI 0), B = 5.8 (95%CI 2.4), C = 4.4 (95%CI 2.5), D = 1.0 (95%CI 0.9) {p=0.04 ANOVA}. Repeated measurements at the macroscopically normal area showed the Mankin grade was maintained; D1= 1.0 (95%CI 0.9), D2 = 0.6 (95%CI 0.5), D3 = 0.6 (95%CI 0.6).
The results show that the retained posterior cartilage in antero-medial arthritis has a consistently normal Mankin grade. We suggest the defect represents a model of progressive cartilage damage from near normal (posterior) to the grossly osteoarthritic state (anterior).
Cells of the intervertebral disc exist in an unusual environment compared to those of other tissues. Within the disc there are low levels of nutrients available, low oxygen levels and it is an acidic environment due to high lactate levels. Apoptosis (programmed or controlled cell death) has been reported in intervertebral discs, as well as necrosis (uncontrolled cell death). This study has focused on examining the sensitivity of nucleus pulpo-sus (NP) cells to several stimuli, in comparison to two other cells types.
Ultra violet (UV) irradiation, serum starvation (with no foetal calf serum) and treatment with 2mM hydrogen peroxide were used to induce apoptosis in cultured bovine NP cells, HeLa (cancer cell line) and 293T cells (human embryo kidney derived) cells. Apoptosis was identified by nuclear morphology following staining with fluorescent Hoechst 33342 dye and propidium iodide; the incidence was measured at 24, 48 and 72 hours. Untreated controls were used for each treatment and at each time point.
The incidence of apoptosis increased with time for all treatments. After 72 hours, UV treatment produced the highest levels of apoptosis with levels of apoptosis occurring in the order of HeLa (94%) > NP cells (29%) > 293T cells (15%). Treatment with hydrogen peroxide and serum starvation induced apoptosis at lower levels in all three cell types (maximum of 30%). Serum starvation induced apoptosis in only 10% of NP cells at 72 hours, compared to 20% in HeLa cells. None of the controls contained apoptotic cells.
NP cells are stimulated to apoptose in response to UV irradiation, hydrogen peroxide and serum starvation. However, levels of apoptosis are much lower after UV treatment in comparison to HeLa cells (3 times lower), suggesting that they may have a protective mechanism to this apoptotic stimulus, compared to HeLa cells. The low levels of apoptosis observed in NP cells with serum starvation may be due to the low nutrient environment that they exist in normally.
Wear debris is a key factor in the pathophysiology of aseptic loosening of orthopaedic endoprostheses. Cobalt-chromium-molybdenum (Co-CrMo) alloys are used for metal-metal hip implants due to their enhanced wear resistance profiles. Whilst these alloys have widespread clinical application, little is known about their direct effect on osteoblast biology. To address this issue, in this study we have investigated particle-mediated inflammation, as a putative mechanism of aseptic loosening. The effects of Co2+ ions on the bone cellular milieu were assessed in vitro by profiling of classical inflammatory mediators. The inflammatory driver PGE2 was quantified and found to be increased, following osteoblast stimulation with metal ions, suggesting the initiation of a local inflammatory response to metal particle exposure. To determine the biological import of this molecular event, the role of metal ions in recruiting inflammatory cells by chemokine production was assessed. These data demonstrated significant induction of the chemokines, IL-8 and MCP-1 following both 12 and 24 hour exposure to 10ppm of Co2+. In this study, we demonstrate that Co2+ particles can rapidly induce chemotactic cytokines, IL-8 and MCP-1 early stress-responsive chemokines that function in activation and chemotaxis of monocytes, and PGE2, which stimulates bone resorption. We have shown that this induction occurs at a transcriptional level with significantly increased mRNA levels. These data lend further weight to the hypothesis that wear mediated osteolysis, is due, at least in part, to underlying chronic inflammation.
The repair of cartilage defects remains a significant clinical challenge. The use of mesenchymal stem cells for cell-based tissue-engineering strategies represents a promising alternative for the repair of the defects. In this study, we investigated the TGF-bate1 dose and cellular density-dependent effect on chondrogenic differentation of human bone marrow-derived mesenchymal stem cells (MSCs) cultured in alginate beads in vitro.
Immunostaining demonstrated that hMSCs and H9 cells express cartilage specific Collagen II and Collagen X.
Leucocytes are white blood cells that help the body fight against bacteria, viruses and tumour cells. However, the activity of leucocytes has been implicated in other clinically important inflammatory conditions such as ischaemic heart disease, stroke, and during cardio-aortic and orthopaedic surgery.
The main objectives of this study was to optimise methods for the isolation of leucocyte subpopulations (neutrophils and monocytes), and to assess in vitro the effects of PMA and fMLP on markers of leucocyte adhesion (CD11b, CD62L) and activation (intracellular hydrogen peroxide) (n=10). Leucocyte subpopulations were labelled by incubation with fluorescein isothiocya-nate (FITC) conjugated anti-human CD11b and CD62L antibodies. The cell surface expression of these labelled adhesion molecules were measured by flow cytometry. Intracellular production of hydrogen peroxide by neutrophils and monocytes was measured by flow cytometry, using the fluorochrome dichloroflurorescin diacetate (DCFH-DA). These were visualised by Immunofluorescence microscopy.
During this study, methods of isolating leucocyte subpopulations from whole blood were optimised. This ensured that these cells were isolated with consistently high yields, purity and with no changes in cellular function. Following incubation with PMA and fMLP, neutrophils and monocytes displayed an increase in CD11b cell surface expression; a decrease in CD62L cell surface expression; and increased leucocyte activation. Leucocyte activation was represented by the intracellular production of hydrogen peroxide.
In conclusion this study confirms that both PMA and fMLP have an intrinsic effect on markers of leucocyte function. These findings are in agreement with previous studies performed.
Bone substitutes have emerged as a promising alternative in surgeries requiring bone grafting, with a large array of materials available for today’s surgeon. Unfortunately, there is currently no definitive method for comparing the potential bone-healing potential of these different materials. We have developed a novel technique for assessing the osteogenic capacity of different bone substitutes in a mechanically-stimulating perfusion bioreactor.
The Zetos(TM) bioreactor system consists of individual flow chambers connected to a low-flow perfusion pump, which recirculates media through samples. The Zetos can be programmed to apply a controlled stress or a controlled strain to each individual sample inside the flow chamber. Since bone formation has been shown to be optimal with short doses of high amplitude strains, test samples were subjected to daily loading corresponding to physiological strain experienced during a jumping exercise (maximum 3000 microStrain).
Three substitute materials representing the range of materials available clinically were tested in the Zetos system; these included collagen, calcium phosphate, and a synthetic polymer. Primary human osteoblasts were seeded onto the substitutes, which were then placed inside the Zetos system and maintained under load or non-load conditions for 14 days. No supplementary osteogenic factors were provided to the cells. The degree of bone formation in the samples was assessed using Von Kossa staining and quantified in terms of the area of new mineral relative to the surface area of the substitute.
No mineralisation was detected in the non-loaded samples. However, in the loaded samples, mineralisa-tion was detected in some of the substitutes. The degree of mineralisation depended on the material: in collagen, an average of 0.22 mm2/mm2 was mineralised; in calcium phosphate, mineralisation averaged 0.0013 mm2/ mm2; but in the loaded polymer samples, no mineralisation was detected.
This indicates that mechanical loading is a sufficient stimulus for bone formation in some materials, even in the absence of other known osteogenic factors. Further, commercial substitutes differ in their ability to support bone formation under conditions of physiological loading. Further development of this technique could allow it to be used as a screening tool for predicting the efficacy of commercial products.
A combination of stem cell therapy and tissue engineering is emerging as one of the most promising approaches for skeletal tissue repair and regeneration. Osteoinduction of human bone marrow mesenchymal stem cells (MSCs) is initiated through local signals or growth factors, of which the bone morphogenetic proteins (BMPs) are the best characterised. Cytomodulin-1 (CM-1), a synthetic heptapeptide with functional similarity to members of the TGF-B super family, has been classified as a novel growth factor associated with osteoinduction of MSCs. However, the effects of CM-1 on human bone MSCs are still unclear. The aim of this study was to determine any effects for CM-1 and its scrambled control (CM-1 SCRAM) on the proliferation and differentiation of human bone marrow MSCs along the osteogenic lineage.
Primary human bone marrow MSCs were cultured in the presence of CM-1 and CM-1 SCRAM at a range of concentrations (10-8M – 10-6M) in vitro for up to three weeks. 100 ng/mL of recombinant human BMP-2 (rhBMP-2) was used as a positive control. At the end of the culture period, histological and biochemical assays were carried out on the cultures.
Biochemical assays revealed that 10-7M of CM-1 significantly stimulated alkaline phosphatase specific activity compared with the negative control group (P< 0.05) in a similar way to the rhBMP-2 positive control group. These data were supported by an observed increase in positive alkaline phosphatase staining in the 10-7M of CM-1 and rhBMP-2 treated cells. However, total DNA content was not significantly different between any of the groups.
This study indicated the potential of using CM-1 as an osteogenic growth factor for skeletal tissue regeneration which may provide an alternative approach to meet the major clinical need in orthopaedics and craniofacial surgery.
* Cytomodulin-1 and the scrambled control were genuine gifts from Professor (emeritus) Rajendra S. Bhatnagar at the Department of Bioengineering, University California Berkley, USA.
To illustrate our clinical experience of using a complete biological method of fixation in ACL surgery and correlate the histology at the graft and the host bone interface performed in an animal experiment.
Patients began immediate knee exercises with continous-passive-motion devices in the recovery room. With 100 degrees of knee motion, they allowed to bear full weight on the operatively treated limb with knee in a brace in extension
6 prostheses that used ball bearings to achieve length (designed in 1981) were implanted, 3 (50 %) were revised due to mechanical failure.
19 prostheses that utilised external C-washes (1998) to achieve length were implanted, 6 (32 %) were revised, half of these for mechanical failure.
Of the 98 minimally invasive prostheses (1992) that utilized an Allan key and screw-jack mechanism to lengthen, 14 (14 %) were revised, half of these for infection.
17 non-invasive extendable endoprostheses (2001) that are lengthened by electromagnetic coupling have been implanted so far. There has only been 1 (6 %) revision. This was due to full extension being reached.
Key Words: Bone tumour, children, endoprosthesis, survivorship.
Conclusion: We conclude that total femur endoprosthetic replacement offers an excellent method of limb reconstruction following excision of the whole femur either for primary or metastatic tumours. However, patients survival after such operation is poor due to disease related factors.
We have investigated whether improvements in design have altered outcome for patients undergoing endoprosthetic replacement of the distal femur following tumour resection.
Survival of the implant and ‘servicing’ procedures has been documented using a prospective database and review of the implant design records and case records.
A total of 335 patients underwent a distal femoral replacement with 162 having a fixed hinge design and 173 a rotating hinge. The median age of the patients was 24 years (range 13–82yrs). With a minimum follow up of 5 years and a maximum of 30 years, 192 patients remain alive with a median follow up of 11 years. The risk of revision for any reason was 17% at 5 years, 34% at 10 years and 58% at 20 years. Aseptic loosening was the most common reason for revision in the fixed hinge knees whilst infection and stem fracture were the most common reason in the rotating hinges. The risk of revision for aseptic loosening in the fixed hinges was 32% at ten years compared with 4% for rotating hinge knees with a hydroxyapatite collar. The overall risk of revision for any reason was halved by use of the rotating hinge.
Ambulation improved in 5, was unchanged in 5 and deteriorated in one. Neurological status deteriorated in 4 and remained static in the others. However in all but one case the neurological deficit was defined by the nature of proposed surgery. Mean survival from surgery for patients with metastatic disease was 9.5 months (3–18). At mean follow up of 10 months (1–19 months), all patients with primary tumours were still alive without evidence tumour recurrence.
Extralesional excision, and therefore potentially curative surgery, was achieved in 4 cases where this was the primary goal of surgery (osteosarcoma, osteoblastoma, chordoma, embryonic rhabdomyosarcoma). There were no cases of metalwork failure. One patient has undergone revision surgery for pseudathrosis.
Whether or not the referral met established referral guidelines for bone and soft tissue tumours The proportion of patients seen within two weeks The proportion of patients referred under the guidelines that had malignant tumours.
This was compared with the total number of referrals to the unit and their tumour detection rates.
A total of 40 patients were referred as “two week waiters” in the given time period. They were seen on an average of 8 days following the referral. Of the 40 patients, four patients had soft tissue metastasis from a primary tumour elsewhere, and six had primary malignant soft tissue tumours. 12 had a benign bone/ soft tissue tumour. 18 (45%) patients had a non neoplastic pathology (6 Muscle tear/ herniation; 4 ganglion/bursa; 2 lumps that disappeared)
During the same period a total of 515 patients were referred by other routes.
Excision was complete in 23 patients and incomplete in 17. Histology revealed dedifferentiation in 4. Complete excision margin was achieved in 69.6% through combined approach and 52.9% through posterior approach only. 24 patients (52%) had local recurrence. Without adjuvant radiotherapy the mean disease-free period following complete excision was 3.5 years, compared to 0.9 years following incomplete excision. Adjuvant radiotherapy extended the mean disease-free period following incomplete excision to 1.8 years.
Cellular mechanisms that account for tumour osteolysis associated with Ewing’s sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor κB ligand (RANKL)-dependent and RANKL-independent mechanisms. In this study our aim has been to determine whether tumour-associated macrophages (TAMs) isolated from Ewing’s sarcoma are capable of differentiating into osteoclasts and to characterise the cellular and humoral mechanisms whereby this occurs. TAMs were isolated from two Ewing’s sarcomas and cultured on both coverslips and dentine slices for up to 21 days with soluble RANKL and human macrophage colony stimulating factor (M-CSF). Osteoclast formation from TAMs (CD14+) was evidenced by the formation of tartrate–resistant acid phosphatase and vitronectin receptor-positive multinucleated cells which were capable of carrying out lacunar resorption. This osteoclast formation and resorption was inhibited by the addition of the bisphosphonate, zoledronate. Osteoclast formation was also seen when Ewing’s sarcoma-derived TAMs were cultured with TNF α in the presence of M-CSF. We also found that TC71 Ewing’s sarcoma cells were capable of independently stimulating osteoclast formation through the release of a soluble factor. These results indicate that TAMs in Ewing’s sarcoma are capable of osteoclast differentiation by both RANKL-dependent and RANKL-independent mechanisms and that Ewing’s sarcoma cells produce an osteoclastogenic factor. The role bisphosphonates may play in inhibiting osteoclast formation and osteolysis in Ewing’s sarcoma merits further investigation.
We report the clinical, radiographic and histologic features of these cases.
There were no infections in this series.
Three subjects required revision surgery.
This study suggests that resurfacing arthoplasty can also induce a local hypersensitivity reaction in response to metal wear debris. It therefore raises new concerns regarding the long-term safety of this procedure.
in the immature group, 6 patients (ex 35; 17%) developed a further manifestation of the condition (2 had recurrences at same site; 2 developed a distinct focus in bone; 1 developed a distinct soft tissue lesion causing spinal cord compression; 1 developed diabetes insipidus), in the mature group, 3 patients (ex 26; 12%) developed a distinct focus in bone but there was no other recurrence/progression.
Giant cell tumor of bone is a benign lesion that is ‘locally aggressive and potentially malignant’. The most common specific location of ‘GCT’ is about the knee (50–65%), followed by the distal radius (10–12%), sacrum (4–9%) and proximal humerus (3%–8%). The pelvis is recognized as an infrequent site of involvement accounting for as few as 2% to 3% of all giant cell tumors. Giant cell tumors often can reach an alarming size in the pelvis jeopardizing the surrounding structures.
Treatment options described in literature for pelvic giant cell tumors include radiation therapy; surgery with intralesional margin; surgery with an intralesional margin and physical adjuvants, and surgery with wide margins.
Following Type II (Periacetabular) resections the two preferred modes of reconstruction are either Saddle Prosthesis or Ilio femoral fusion. But, in patients with extensive periacetabular involvement with tumor extension into ilium the type II resection has to be combined with a Type I (Ilial) resection. This may result in insufficient ilium being available for reconstruction to consider either a iliofemoral fusion or a saddle prosthesis. In such situations we recommend Sacroiliofemoral fusion as a novel variation of iliofemoral arthrodesis.
We present two cases of GCT of pelvis with significant periacetabular involvement treated by Sacroiliofemoral fusion. A follow up at 2 years in both cases showed no recurrences, mean MSTS of 21 & TESS of 70.
This paper discusses the various treatment options for such extensive periacetbular giant cell tumors, operative technique for sacroiliofemoral fusion, outcome evaluation after 2 years by MSTS & Toronto Extremity Salvage scores.
Allografts are an alternative to endoprosthetic reconstruction but high incidence of complications such as fracture, deformity and infection makes the outcome unpredictable. The treatment option of reconstructing the resected gap with endoprosthesis is limited in our Indian subcontinent set up because of limited resource and availibility. The advantage include, the method we used has given us best alternative which allowed us to fill the large resected gap without the need of massive bone grafts. The distraction from both sides of resected gap has reduced the transportation time and use of DCP plate across the docked bone has allowed us to remove the fixator earlier. The regenerate had sufficient biological strength and durability. The disadvantages include the long duration of external fixation and related problems such as pin tract infections and frustration of patients due to the long period of treatment.
Conclusion: Resection of tumour across the joint especially around the knee and recostruction by distraction osteogenesis using Ilizarov construct over the nail to fill the large gaps without using grafts is very encouraging.
We reviewed the treatment and clinical outcome of 32 consecutive patients with Ewing’s sarcoma who presented with or developed pathological fracture after biopsy between 1984 and 2004. The minimum follow-up was 18 months. The mean age at diagnosis was 20 years (5 – 51). There were 18 males and 14 females. All patients were newly diagnosed and had localized disease at the time of diagnosis. 21 patients presented with pathological fracture while 11 patients developed fracture during the course of chemotherapy. The femur was the most common location in 15 patients.
All the patients had chemotherapy according to the protocol current at the time of treatment. 7 patients had radiotherapy alone while 25 patients underwent surgical excision and reconstruction. Of the patients who had surgery, 7 patients had adjuvant radiotherapy. Fracture healing was the norm after pre-operative chemotherapy. Surgical margins were wide in 17 patients, marginal in 4 and intralesional in 3 patients.
Local recurrence developed in one patient (3%). Metastases occurred in 12 patients (37%). At the time of review 16 patients were free of disease, 3 were alive with disease and 13 patients had died of disease. The cumulative 5 year metastases free and overall survival in all the patients was 58% and 61 % respectively and similar to patients with Ewing’s sarcoma without fracture treated at our centre. The prognosis of patients who presented with fracture was exactly similar to those who developed fracture in the course of treatment.
We conclude that limb preserving surgery is perfectly safe in patients with Ewing’s sarcoma who have associated pathological fracture and survival is not in any way compromised. Survival of patients who present with fracture is similar to those who develop fracture in the course of treatment. The exact role of adjuvant radiotherapy in these patients needs to be clarified.
The management of pathological fractures in children remains controversial. The indications for surgical treatment are unclear and the need for histological diagnosis before or after definitive treatment is not clearly defined.
We reviewed retrospectively the records of all patients under the age of 16 years who presented over the past 7 years with a fracture as the first manifestation of bone pathology. There were 26 patients (19 boys and 7 girls) of an average age of 12 years and 2 months (range 4.1–15.8 years).
There were 9 cases of fracture through a simple bone cyst, 6 in the humerus and 3 in the femur. In all cases the fracture was treated conservatively initially. Subsequent management included needle biopsy in all, followed by bone marrow injection under the same anaesthetic. The patients suffered a refracture and were treated with flexible intra-medullary nail fixation.
There were 5 cases of fibrous dysplasia, of which 2 in the femur, 2 in the tibia and one in the proximal radius. Histological diagnosis was obtained in all cases prior to definitive treatment. This included a locked intra-medullary nail in one patient and flexible nailing in another two. The remaining two patients are still under observation.
There were 2 patients with giant cell tumour, 3 patients with aneurysmal bone cyst and one patient with chondroblastoma. Histological diagnosis preceded treatment with curettage and grafting in all these cases. There were 6 patients with malignant primary bone tumour, 1 adamantinoma, 2 osteosarcoma, and 3 with Ewings Sarcoma.
The 3 patients with Ewing’s sarcoma involved the femur. One had extensive local disease and early intra-medullary nailing was performed for palliative reasons. The second patient was treated conservatively initially. Definitive surgery was performed after fracture healing and included segmental resection and vascularised fibular graft. The third patient was initially treated elsewhere. She was thought to have a benign lesion and internal fixation with a screw/plate device was performed. Histology from intra-operative specimens confirmed Ewing’s sarcoma. Definitive surgery required extensive resection and prosthetic replacement.
The 2 patients with osteosarcoma had fracture of proximal humerus and distal femur. The former was treated by forequarter amputation as there was tumour involvement of brachial plexus and remains AWND at 7 years. The latter had resection and EPR of the distal femur.
One patient with adamantinoma underwent segmental resection and reconstruction with VFFG
We recommend that primary fixation of pathological fractures should be avoided until histological diagnosis is obtained. However, if radiographic appearances are reassuringly benign, biopsy can be delayed until conservative fracture management is completed. Definitive treatment of benign lesions with protective intramedullary nailing or curettage and grafting can follow frozen section under the same anaesthetic.
Between 1948 and 2004, we report 34 patients with Ewing’s sarcoma of pelvis accrued from Scottish Bone Tumour Registry, aiming to identify the prognostic factors and the influence of various treatment modalities on outcome. There were 19 male and 15 female patients at a mean age of 19 years (range, 3 to 48 years). The Pain was main presenting symptom in 30, swelling in 12 and restriction of hip movements in 11 patients. The commonest anatomical site was ilium. Local control was achieved by surgery, radiotherapy (n=25), chemotherapy (n=23) or a combination. The survival correlated significantly with chemotherapy protocols in favour of the group that received ifosamide (p< 0.01). Metastases at presentation was the most important factor determining survival (P< 0.01). Among the patients who presented without metastases (n=25), there was no statistically significant difference in survival based on the anatomical location of the tumour, age or sex. The mean time to lung metastases from the date of presentation was 13 months, while bone metastases presented at an average of 20 months. None of the patients with the metastasis or local recurrence survived. There were 5 local and 17 systemic (metastatic) relapses. The mean duration of survival was 13 months.
With advances in imaging, aggressive chemotherapy, surgery and conformal radiotherapy which can deliver high dose of radiation with precision, it is possible to achieve a cure rate of more that 50% in non-metastatic pelvic Ewing’s sarcoma. The results of this study favour a middle-path regime combining all treatment modalities.
The bone defect consolidated fully, with no talar collapse, in all 8 cases. 5 of the 8 patients had no pain and full range of movement at last follow-up. 4 patients had no evidence of osteoarthritis at last follow-up, 2 patients had OA grade 1, one had OA grade 2, and one had OA grade 3 pre-operatively which then progressed to grade 4. One patient had two episodes of local recurrence which were treated by curettage and bone grafting, then by radioablation.
99 patients with new diagnosed soft tissue sarcomas involving the pelvic region were studied to determine the outcome and prognostic factors for survival and local recurrence.
The mean age at diagnosis was 57 years. There were 55 males and 44 females. The mean tumor size was 12cm. The tumor was deep in 79 patients and superficial in 20. Surgical treatment was excision in 93 patients and hindquarter amputation in 6 patients. Histological grade was low grade in 23 and high grade in 75 patients. 7% of the patients had metastases at presentation.
The 5 year overall survival was 57% and local recurrence occurred in 22% of the patients. The risk of inadequate surgical margins in patients with tumors within the pelvic brim was 50% compared to 18% for those with tumors located outside the pelvic brim. The significant predictors of local recurrence were inadequate margins and location of the tumor within the pelvic brim. Tumor size, grade and depth did not influence development of local recurrence. Significant predictors of survival included metastases at presentation, tumor grade and depth. The cumulative 5 year survival for patients with deep high grade tumors, deep low grade tumors, superficial high grade and superficial low grade tumors were 45%, 74%, 63% and 100% respectively (p=0.01). The 5-year overall survival was 66% in those patients without local recurrence compared to 37% in those who develop local recurrence (p=0.005). Multivariate analysis revealed that development of local recurrence was the most important determinant of overall and metastases free survival.
We conclude that patients with pelvic soft tissue sarcoma who develop local recurrence have an extremely poor prognosis. Patients with high grade and inadequate surgical margins represent a particular group with very high risk of metastases and death even with radiotherapy and perhaps should be considered for other adjuvant treatment.
13 presented in the extensor compartment and 2 flexor compartment at the level of the distal radius. All presented with a painless mass. 5 patients with neurological symptoms. 4 involving the post interosseus nerve and 1 radial nerve. MRI was the diagnostic imaging technique of choice, 2 had biopsies where there was atypical imaging features.
All underwent planned marginal excision preserving juxtaposed peripheral nerve. There were no radial, spiral or PIN nerve palsies. One patient presented with PIN palsy had partial resolution of symptoms and function. I wound infection
54 patients had conventional osteosarcoma. Average age of diagnosis of 58.8 years, male to female ratio of 3:2 and 37% were femoral. Median survival was 11 months.
13 patients had radiation-induced osteosarcoma. Average age of diagnosis of 67.2, male to female ratio of 1:6 and 5 out of the 13 had pelvic osteosarcoma. Median survival was 8 months.
We report the results of contained bone defects after curettage of benign bone tumours of the distal radius treated without bone grafting or the use of bone substitute. 11 consecutive patients treated with follow-up of 3 to 11 years (mean 5.7 years) were studied. The mean age at diagnosis was 27 (range 11 to 55). There were7 males and 4 females. Histological diagnosis was giant cell tumour in 8 and aneurismal bone cyst in 3 patients. The mean bone defect at diagnosis was 23.7cm3 (9.2 – 68cm3). Pathological fracture was present in 5 patients prior to surgery. We observed full radiological consolidation of the defects in all the patients within 12 months of surgery. Radiologically detectable osteoarthritis was noted in 5 patients (grade 1 in two patients, grade 2 in one and grade 4 in two patients). Development of osteoarthritis was significantly related to size of the defect and involvement of the joint by the original tumour. No patient without joint involvement developed osteoarthritis. There was no relationship between pathological fracture and development of osteoarthritis.
We conclude that contained bone defects in the distal radius do rapidly consolidate without the use of bone grafting or bone substitute. The bone remodels nicely over time. Development of osteoarthritis is related to the damage to the articular defect caused by the tumour.
Synovial sarcoma is a morphologically well-defined neoplasm that most commonly occurs in soft tissue accounting for 5% to 10 % of all soft tissue sarcomas. We reviewed 156 patients with synovial sarcoma of soft tissues treated at a supra-regional centre to determine survival and prognostic factors.
There were 77men and 79 women with mean age at presentation of 38 years (3 to 84). Follow-up periods ranged from 3 to 494 months (median 43 months). Tumor was located in lower extremities in 111patients, upper extremities in 34 patients, and trunk and pelvis in 11 patients. Overall survival was 66% at 5 years and 48% at 10 years. The 5 and 10 year survival for the 23 patients who had metastases at the time of diagnosis was 13% and 0% respectively compared to 75% and 54% for those without metastases at diagnosis. Local recurrence occurred in 18 patients (13%). The significant prognostic factors for survival included presence of metastases at diagnosis and development of local recurrence. Tumour size and depth, age of patients and use of chemotherapy did not significantly influence survival.
We conclude that the clinical factors which influence survival of patients with synovial sarcoma are different from those of soft tissue sarcomas in general. Biological factors may better predict prognostic survival than the usual clinical factors.
To assess the referral system and the clinical notes and radiographs of patients presenting with metastatic disease of long bones.
All oncology consultants and registrars received a questionnaire regarding referral to the orthopaedic department for metastatic disease of the appendicular skeleton.
Ninety three percent of oncologists did not use a reliable scoring system to assess risk of pathological fracture. The majority of oncologists referred with regards to degree of cortical erosion and increased pain on weight-bearing. Sixty percent felt an improvement in communication between the departments was required.
The notes and radiographs were reviewed of twentyfive patients presenting with femoral metastatic lesions to the oncology department.
Mirels scoring system was then applied to each patient to assess the risk of the possibility of a pathological fracture.
Ten patients had a Mirels score of greater than eight. Three patients were referred for an Orthopaedic opinion regarding prophylactic fixation. Two patients had no fracture of the femur after three months. Five patients had a pathological fracture within three months, resulting in an emergency admission for surgery.
Three patients had a Mirels score of 8. One patient suffered a pathological fracture.
Twelve patients had a Mirels score of less than 8. None of these patients were referred for an Orthopaedic opinion. None of these patients had a pathological fracture within three months.
In conclusion, we presently do not offer a multidisciplinary approach to metastatic disease affecting the appendicular skeleton.
The majority of patients’ who score eight or above in the Mirels scoring system are at risk of fracture and do require prophylactic surgery.
In keeping with the BOA guidelines, “Metastatic Bone Disease: A Guide to Good Practice”, we would recommend the introduction of a multidisciplinary approach and the use of a recognised scoring system to improve patient care.
Introduction: The distal tibia is an uncommon site for primary malignant bone tumours and the treatment of choice for most patients is a below knee amputation. Patients who decline an amputation may be offered an endoprosthetic replacement. This is a technically challenging operation and may be associated with high morbidity.
A literature search on genetic studies was performed using the key term as familial chordoma and following studies have been found-
Kelly et al- the study had 10 affected members and showed linkage to chromosome 7q 33. Miozszo et al- the study had 3 affected family members and showed tumour suppressor locus on chromosome 1p36. Stepanek et al –the study had affected 4 members in a family and showed probable autosomal dominant inheritance.
Limb salvage surgery includes all of the surgical procedures designed to accomplish removal of a malignant tumour and reconstruction of the limb in order to achieve an acceptable oncological, functional, and cosmetic result. The aim of this study was to evaluate the functional outcome following endoprosthetic replcament for primary upper & lower extremity musculoskeletal neolplasms.
Between 1983 and 2004, we found 68 patients from the Scottish Tumor Register having had an endoprosthetic reconstruction for upper and lower-extremity malignant musculoskeletal tumours, of which 32 were alive for performing functional assessment (lower extremity-26, upper extremity-6). The clinical, radiological and oncological outcomes were evaluated. The functional outcome was measured by the Musculoskeletal Tumor Society and Toronto Extremity Salvage Score.
The average follow-up was 59 months (range, 1 to 21 years). There were 19 female and 13 male patients. These were anatomically distributed as around the knee (n=18 cases), hip (n=8) and shoulder (n=4). The most common diagnosis was chondrosarcoma (n=10) and osteosarcoma (n=11). Most of the patients were completely satisfied with their condition, with a decreased walking distance as the only notable restriction. There was no correlation between the functional outcome and the type or site of resection. Complications occurred in ten cases, including two cases of aseptic loosening and one case each of recurrent instability, sciatic nerve palsy and femoral nerve palsy. The median functional score using the Musculoskeletal Tumour Society system was 56% and Toronto Extremity Salvage Score was 72%.
Limb salvage for malignant musculoskeletal tumours continues to pose therapeutic and oncological challenges with considerable functional issues, but the good function and local tumour control in most patients justifies its continued use.
Four patients had obvious infection confirmed by histology and/or microbiology prior to surgery. Endoprosthetic Reconstruction was performed as a 1 stage procedure in 13 and as a 2 stage in 4.
Complications occurred in 5 patients. These included recurrence of infection in 1, persistent pain in 1, aseptic loosening in 1, periprosthetic fracture in 1 and a non ST myocardial infarction in 1. At the last follow-up, (mean 5years, range 1–18years) majority of patients achieved good range of motion and good mobility.
We report the case of an 80-year-old woman treated by palliative knee arthrodesis for metastases of the proximal left tibia secondary to bladder carcinoma, using percutaneous femortibial intramedullary arthrodesis nailing.
The technique provided a simple alternative to massive allografting, total joint prosthesis or amputation, with advantages of low morbidity, short operating time, minimal blood loss, immediate ambulation and weight bearing, relief of pain, restoration of independence, and ease of nursing care.
We are satisfied with the procedure of percutaneous femorotibial intramedullary nailing as a palliative treatment of proximal tibial metastases in an elderly patient.
Primary lymphomas of bone are uncommon malignancies with involvement of spine, long bones, pelvis, ribs and skull in decreasing order of frequency. We describe an unusual case who presented with recurrent knee effusions turned out to be a high grade B-cell non-Hodgkin lymphoma.
A 34-year-old man is presented with painful recurrent knee effusions without any systemic aberration. Multiple aspirations were carried out to help knee pain and swelling with immediate response, but had negative cytology. Hematological and biochemical parameters were normal. Plain radiographic examination of the knee failed to show any bony abnormalities. An MRI scan of the knee showed extensive marrow oedema of the distal femur with breach in the anterior cortex. Subsequently, open biopsy of the lesion was carried out which confirmed the diagnosis of a high grade B-cell Non-Hodgkin lymphoma. Staging CT-scan of the chest, abdomen and pelvis failed to show any other lesions elsewhere. He was subsequently treated with the help of multi-drug chemotherapy and radiotherapy. At 7 months post treatment, the patient had no relapse and a repeat MRI at 7 months showed reduction in the size of lesion.
This case illustrates the limitations of plain radiograph and the usefulness of MRI in the diagnosis of bony lymphoma. The diagnostic dilemmas while investigating recurrent knee effusions due to primary skeletal Non Hodgkin lymphoma should be resolved by timely MRI scan and histological diagnosis.
A 63 year old male had a pathological fracture of the proximal femur treated by DCS fixation. The fracture failed to unite and the plate fractured. Despite this the patient was able to walk with crutches, pain free.
Intraosseous schwannoma is a rare benign neoplasm, which most commonly arises in the head and neck region particularly the mandible, due to the long intraosseous path of sensory nerves in the mandible. We present a 27-year-old lady with an unusual presentation of an intraosseous schwannoma of the first metatarsal. There is only one report published previously of an intraossous schwannoma of the lesser metatarsal bone of the foot.
A 27-year-old woman presented with painful left forefoot following a trip while walking. Plain radiographs demonstrated a pathological fracture through a lytic lesion of the first metatarsal of the left foot. MRI scan using axial T1-weighted spin echo and axial and sagittal T2-weighted gradient echo showed an amorphous mass occupying the medulla of the bone but with a breach of the plantar aspect of cortex with apparent localised destruction. Ultrasound-guided biopsy was performed. Haematoxylin and Eosin stained specimen sections showed a proliferation of spindle cells of alternating hypercellularity and hypocellularity. This case was managed by curettage and grafting with autograft and synthetic bone substitute. At two-year follow-up, the radiographs showed complete graft incorporation and a healed cyst. The patient was clinically asymptomatic with return of full functions. There were no clinico-radiological findings to suggest any recurrence.
Due to rarity and non-specific clinico-radiological features, this case illustrates the necessity of a multi-disciplinary approach with an accurate histological diagnosis in combination with radiological and clinical appearances.