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Volume 90-B, Issue SUPP_II July 2008

J.J. Candal-Couto G. Gamble T. Astley A. Rothwell C. Ball

The aim of the New Zealand Elbow Arthroplasty Register is to evaluate the provision of elbow arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all elbow replacements performed in New Zealand. An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete a questionnaire to measure the pain and function of the replaced elbow and to comment on any post operative complications. Data from 99 consecutive primary and 16 revision elbow arthroplasties was prospectively collected from January 2000 till December 2003. Rheumatoid arthritis was the commonest indication (63 cases) and the outcome was significantly better than for trauma and osteoarthritis. The Coonrad-Morrey was the most commonly used prosthesis (86 cases) followed by the Kudo (eight cases) and the Acclaim (five cases). 21 surgeons performed elbow arthroplasty during the study period but only five performed on average more than one case per year. Their results at six months were statistically superior to those provided by other surgeons. The number of complications reported by patients and the revision rate within the study period was low. An infection was seen in only two patients. The New Zealand Elbow Arthroplasty Register has become a robust method of assessment of the provision of elbow arthroplasty within the country. Our findings support the idea that elbow arthroplasty should not be performed by general orthopaedic surgeons on an occasional basis.


A.G. Martin D. Simmons L.P. Tiessen C.E. Bache

We compare the management and outcome of two management stratergies for the perfused but pulseless hand following stabilisation of grade III supracondylar fractures in children.

For this study we looked at 15 patients treated in two centres (all treated by the senior author) between 1995 and 2004. The patients were designated to group I if the pulseless hand had been observed or group II if they underwent immediate exploration. Data collected included time to surgery, neurological deficit, time to return of pulse and subsequent symptoms of forearm claudication. All patients were seen at week 1,3 and followed for at least 6 months post surgery. Radiographs were reviewed to determine the adequacy of reduction of the fracture.

The mean age of patient was 3.8 years. Median time to surgery was 6 hours. 6 children had evidence of anterior interosseus nerve palsy. 12 cases were reduced anatomically, 3 had minimal fracture gap. Of the 8 patients in group I (observation) 2 had secondary exploration and one developed claudication symptoms. All had palpable radial pulse at 3 months.6 of the 7 patients in group II (exploration) were seen to have brachial artery tethering, 2 with median nerve entrapment. 5 of them had subsequent return of radial pulse within 24 hours.

Satisfactory radiological reductionof the fracture does-not exclude vessel or nerve entrapment. We would advocate early exploration of the artery if the pulse does not return within 24 hours.


A. Rajeev J. Pooley

Goodfellow & Bullough (1968) first described the pattern of articular cartilage wear in the elbow. More recent post mortem studies have shown that advanced degenerative changes can develop in the radio-capitellar (lateral) compartment of elbow joints of elderly subjects in which the humeroulnar (medial) compartment remains remarkably well preserved. We have reviewed the findings in a consecutive series of 117 elbow arthroscopies performed on patients with elbow pain resistant to conservative treatments (age range 21–80 years: mean age 51 years). We documented established degenerative changes involving articular cartilage in 68 patients (59%). In this group we found that in 60 patients (88%) the degenerative changes were confined to the lateral compartment and contrasted with normal appearances of the articular cartilage of the medial compartment.

The post mortem studies carried out on mainly elderly subjects demonstrated that the degree of degenerative change in the elbow is age dependant and involves predominantly the lateral compartment of the joint. Our study would support these observations, but indicates that symptomatic degenerative change occurs at a much earlier age than had previously been thought.

We consider that lateral compartment degenerative change is a distinct clinical entity. It begins in relatively young patients in whom the x ray appearance may be normal or near normal and is often diagnosed as lateral epicondylitis. Our observations taken together with the reported post mortem studies indicate that primary osteoarthritis of the elbow begins in the lateral compartment of the joint and may remain confined to the lateral compartment throughout life. We believe that new treat ment strategies need to be developed specifically for patients with primary osteoarthritis as opposed to degenerative joint disease due to other causes.


S Thomas GH Broome

Aim: To assess the outcome of open release of the common extensor origin in the management of tennis elbow after the failure of non operative treatment methods.

Methods: 18 patients (24 elbows) between the age group of 38 to 59 who underwent open release of the common extensor origin by the same team after a mean waiting time of 23 months from the onset of pain and a trial of failed non operative methods like analgesics/nsaids, physiotherapy, local steroid injections were contacted and asked to score the effectiveness of surgery after a gap of six months. Since the predominant troubling symptom for all patients was pain they were asked to score the pain relief correlating with the surgery.

Results: In 15 patients (83%) excellent pain relief (defined as an 8 or more out of 10 improvement) was achieved and they regained normal use of the limb. One patient (5%) had moderate improvement (score between 6 and 7 out of 10) and two further (11%) patients gained minimal benefit with persistent symptoms (score 5 out of 10). None of the patients suffered deterioration as a result of surgery.

Conclusion: This study proves that despite new advances in the treatment of tennis elbow, release of the extensor origin by the open method which is a simple and economical day case procedure, still remains an excellent option in cases where trial of non operative management has failed.


Mr M. D. Brinsden Mr J. L. Rees A. J. CarrNuffield

We present a single-surgeon series of surgical release of post-traumatic flexion contracture of the elbow performed via a limited lateral approach. We undertook a retrospective review of patients having surgery for established post-traumatic flexion deformity of the elbow. All patients underwent anterior capsulectomy via a limited lateral approach. Patients with an intrinsic contracture also had the intra-articular lesion addressed at the time of surgery. Short-term follow-up was available from clinical review until discharge. Medium-to-longterm follow-up was conducted by telephone interview supplemented by clinical review in selected cases.

Between 1998 and 2004, 23 patients were treated surgically for established flexion contracture of the elbow. There were 15 males and 8 females with a median age of 35yrs (range 16–52yrs). In sixteen patients the contracture was not associated with damage to the joint surface (extrinsic) and in seven it was (intrinsic). The mean pre-operative deformity was 55 degrees (95%CI 49 “ 61) which was corrected at the time of surgery to 18 degrees (95%CI 12 “ 23). The mean residual deformity was 25 degrees (95%CI 20 “ 31). The difference between the pre-operative and discharge deformities was significant (Wilcoxson test p< 0.001). In the extrinsic group the mean deformity at discharge was 21 degrees (95%CI 17 “ 25) compared to 34 degrees (95%CI 19 “ 49) in the intrinsic group “ this difference was significant (Mann-Whitney U test p< 0.01). In those patients with an extrinsic contracture all elbows had a return of functional extension. One patient suffered a post-operative complication with transient dysaesthesia in the distribution of the ulnar nerve which resolved after six weeks. Surgical release of post-traumatic flexion contracture of the elbow via a limited lateral approach is a safe, reliable technique with the best results achieved in patients with an isolated extrinsic contracture.


A.G. Martin D. Simmons A. Malviya C.E. Bache

The aim of this study was to establish the consensus of opinion amongst trauma surgeons for the management of displaced supracondylar fractures of the humerus in children.

We carried out a postal questionnaire involving 130 orthopaedic surgeons with an interest in paediatric trauma. They were identified as being members of the British Society for Children’s Orthopaedic Surgery.

We received a response rate of 65%. One third of respondents believe that in uncomplicated fractures, reduction should occur within 6 hours of injury and one half felt that ‘pulseless’ fractures should be treated in the same time frame. 60% said they would explore a pulseless arm after midnight, but only 20% would reduce and stabilise uncomplicated fractures. 82% of surgeons stabilise displaced grade III fractures with K wires, of these, the majority would use a‘crossed’ configuration. If after stabilisation the arm remained pulseless, only 16% said they would explore the brachial artery immediately, 23.5% would seek a vascular opinion and 60.5% of surgeons would observe for 24 hours. If the arm remained pulseless but pink after 24 hours, the majority of surgeons would continue to observe and rely on collateral circulation for distal perfusion.

The majority of surgeons would stabilise displaced supracondylar fractures as soon as possible but not after midnight unless the arm was pulseless. If the hand remained pink but pulseless, most felt that continued observation beyond 24 hours was acceptable.


A. Kontaxis G. R. Johnson

The normal shoulder requires the basic mechanical characteristics of range of motion, stability and strength. However, each of these characteristics can be compromised by arthritis or rotator cuff tear and are often associated with strong pain. Shoulder arthoplasty is one of the most common solutions for pain relief and to restore shoulder functionality. There are many available designs of prosthesis trying to address different shoulder pathologies. Despite this, there are relatively few studies investigating the biomechanics of a total joint replacement and suggest advantages, disadvantages and possible solutions.

The Newcastle shoulder model has been used to investigate the biomechanical properties of a total shoulder replacement having a reverse anatomy design. This model allows the simulation of implantation of the prosthesis and the prediction of muscle and joint forces. To address the requirement of accurate insertion of the prosthesis, the standard surgical procedure has been simulated. The current model was modified to represent the bones, muscles and implant alignment after surgery.

Load sharing results for standardised tasks (Abduction, Forward Flexion) showed great differences between anatomical and prosthetic models. In the latter the shear forces on the glenoid site were reversed, the compression stresses were reduced and the joint contact vectors were always within the humeral cup providing joint stability. This is an important effect of the reverse design, which reverses the envelope of the joint forces increasing also the muscle moment arms crossing the GH joint. The most affected group is the m.deltoid that becomes able to compensate for the dysfunctional rotator cuff muscles. The biomechanical model suggests that a reverse anatomy design can restore GH joint stability for patients with severe RC damage. Increased muscle moment arms also compensate for the lost contribution of the RC muscles to elevation.


A. Kontaxis G. R. Johnson

Introduction The complex movement of scapula is significant for the support of the arm and the stability of the shoulder joint. Recent investigations showed an adaptation in scapula rhythm after total shoulder replacement with a big variability within subjects. The latter can change the loading pattern in the glenohumeral contact forces and affect the performance of shoulder prosthesis.

Methods In this study, Newcastle shoulder model was used to simulate a total shoulder arthroplasty and investigate joint stability. The model describes the DELTA ® prosthesis; a reverse anatomy design with a socket component attached to the humeral head and a hemi-ball to the glenoid. Scapula kinematics data of 6 shoulders were recorded using a palpating technique. The subjects had a total shoulder replacement after severe rotator cuff damage. Standard and daily activities were then analysed.

Results and Discussion Scapula kinematics data show an increased scapular lateral rotation, which influences the joint contact forces. Comparing contact forces on the Glenohumeral joint, results indicate that the scapula rhythm adaptation reduces the compressive forces and shifts the shear component more superiorly to the glenoid. The scapula rhythm data used in this study show a large variability, which also affect the loading results. This effect is more significant in “reaching tasks”, where high humeral elevation is required and joint contact loads are maximum. The anterior shear forces in these tasks can be as great as 19% of body weight

Conclusions The adaptation in scapulohumeral rhythm after a shoulder joint replacement has already been reported. The reason for this adaptation cannot be explained yet and may be pain related or due to muscle adaptation that takes place after the arthroplasty. This change in kinematics influences the loading pattern of the glenohumeral joint. In particular the increased shear forces must be taken into considered in prosthetic design.


R.S. Bassi D. Simmons F. Ali D. Nuttall A. Birch I.A. Trail J.K. Stanley

We present the early results of 36 primary total elbow arthroplasties using the Acclaim prosthesis. The Acclaim prosthesis was used in 46 primary total elbow arthroplasties between July 2000 and August 2002. All operations were performed or directly supervised by the two senior authors (IAT and JKS). There were 32 females and 14 males. The mean age at surgery was 64 years (range, 34–93). The underlying pathology was rheumatoid arthritis in 39, osteoarthritis in five and post-traumatic arthritis in two. The early results of 36 cases are presented at a minimum follow-up of two years. Patients were assessed using the American Shoulder and Elbow Surgeons patient self assessment form and the range of movement of the elbow measured. The Wrightington method was used for radiographic analysis of lucencies. There was good relief of pain and range of movement improved. The mean preoperative pain score was 8.1 and decreased to 2.1 at latest follow up. The mean disability score increased from 34.2 to 66.1. The mean overall satisfaction rating following surgery was 9.3 on a visual analogue scale from zero to ten. The mean range of flexion increased from 83oto105o. The mean flexion gain was just over 10o and the mean extension gain was just over 12o. There were 11 cases of intraoperative fracture of the humeral condyle. One of these fractures failed to unite and required revision to a linked prosthesis because of persistent instability. There was one case of deep infection. There were three cases of ulnar neuropathy, one of which resolved. There was no evidence of loosening. The Acclaim total elbow arthroplasty gives good symptomatic relief and improvement in function according to the American Shoulder and Elbow Surgeons patient self assessment form. These early results are encouraging but the frequency of intra-operative fractures is of some concern.


M. Tryfonidis G. K. Jass C. P. Charalambous S. Jacob D. Stanley

A significant number of patients return with persistent symptoms following surgical release of the posterior interosseous nerve for radial tunnel syndrome. The aim of this study was to attempt to explain this fact in anatomical terms by defining the anatomy of the posterior interosseous nerve and its branches in relation to the supinator muscle and arcade of Frohse. Using standard dissection tools 20 preserved cadaveric upper limbs were dissected. The radial nerve and all its branches within the radial tunnel were exposed and a digital calliper was used to measure distances. The bifurcation of the radial nerve to posterior interosseous nerve and superficial sensory branch occurred at a median distance of 4.35mm proximal to the elbow joint-line. The bifurcation was proximal to the joint-line in 11 cases, at the level of the joint-line in one case and distal in eight cases. There was a range of 0–5 branches to the supinator originating proximal to the entry point of the posterior interosseous nerve under the arcade of Frohse at a median distance of 10.27mm (medial branches) or 11.11mm (lateral branches) distal to the elbow join-line. These branches either passed under the arcade of Frohse or entered through the proximal edge of the superficial belly of the supinator. In 10 limbs there was a variable number of branches to the supinator originating under its superficial belly and in five limbs multiple perforating posterior interosseous nerve branches within the muscle were identified. This variation in anatomy we believe may explain the persistence of symptoms following surgical release of the posterior interosseous nerve for radial tunnel syndrome and suggests that careful exploration of all the nerve branches during surgical decompression should be routinely performed.


Joshua T. Wies Helen Humphreys Melanie Latham Petra Enrico Therese Viljoen Brian Hazleman Cathy Speed

The purpose of this study was to assess the efficacy of physiotherapy approaches to treatment of rotator cuff tendinopathies (RCT). Ninety shoulders were randomised in the study. A power calculation performed demonstrated using a factorial study design, 85 shoulders would be needed for 80% power at 95% confidence. All participants gave informed consent and ethical approval was granted by the Cambridge LREC. The primary outcome measure was the Shoulder Pain and Disability Index. Participants were blinded to their allocation and were randomised to one of four groups: Therapeutic Exercise(T), Manual Therapy(M), combined T/M (X), or Placebo(P). Participants were seen for two baseline assessments with a 4-week interval and then randomised. Final assessments were performed one week after the last session. The analysis involved a comparison between groups in change from baseline SPADI using ANCOVA adjusting for baseline scores. This involved testing for any interaction between M and T, and subsequently testing for main effects of M and T. Adjusted baseline and final SPADI scores (SD) by group were: X 41.6(15.4), 21.1(20.8); T 47.6(19.3), 26.3(14.7); M 44.1(17.9), 33.1(23.3); and P 39.5(24.7), 36.6(30.6). The main effects (with Significance, Standard Error and Confidence Interval) by group were: Baseline=0.686 (SE=0.104;CI=0.479,0.892); T=−13.347 (p=0.002;SE=4.091;CI=−21.479,−5.215); X=5.479 (p=0.510;SE=8.284; CI=−10.991,21.950); M=−4.126 (p=0.314;SE=4.077;CI=−12.230,3.978). A statistically significant reduction in SPADI was observed for the T group alone. There was no significant interaction effect with the addition of manual therapy and the M group did not improve significantly. It appears that best practice for treatment of RCT should centre around therapeutic exercise.


A.K. Al-Shawi T.D. Bunker

Ultrasound imaging has become an essential adjunct to clinical examination when assessing a patient with suspected rotator cuff pathology. With the new high-resolution portable machines it has become feasible for the shoulder surgeon to perform the scans himself in the clinic and save a great deal of time. This study was conducted to examine the accuracy of the ultrasound scans performed by a single surgeon over a period of four years. The ultrasound findings were uniformly documented and collected prospectively. Out of a total of 364 scanned patients we selected 143 who ultimately received an operation and we compared the surgical findings with the ultrasound reports. The intra-operative findings included 77 full thickness supraspinatus tears, 24 partial thickness tears and 42 normal cuffs. Three full thickness tears were missed on ultrasound and reported as normal / partially torn. Four normal/ partially torn cuffs were thought to have a full thickness tear. This presents 96.3% sensitivity and 94.3% specificity for full thickness tears. Three partial thickness tears were reported normal on ultrasound and eight normal cuffs were thought to have partial thickness tears. This presents 89% sensitivity and 93.7% specificity for partial thickness tears. The size estimation of full thickness tears was more accurate for large/massive tears (96%) than moderate (82%) and small/pinhole tears (75%). The tear sizes were more often underestimated which may partly reflect disease progression during the unavoidable time lag between scan and surgery. We conclude that shoulder ultrasound performed by a sufficiently trained orthopaedic surgeon is a safe and reliable practice to identify rotator cuff tears.


C.A. Peach Y. Zhang M.A. Brown A.J. Carr

Progressive arthritis can occur in association with massive tears of the rotator cuff. Altered joint kinematics are commonly proposed as the principle causative factor but this does not explain the absence of arthropathy in some patients. We have investigated the role of the ANKH gene in patients with cuff tear arthropathy. The transmembrane protein ANKH promotes intracellular to extracellular inorganic pyrophosphate channelling which regulates calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition. Genomic DNA was prepared from peripheral blood leucocytes from 20 patients with cuff tear arthropathy diagnosed clinically and radiologically and 24 healthy matched controls. All 12 exons and exon-intron boundaries from the ANKH gene were PCR amplified and sequenced with BigDye version 3.1 terminator kit (ABI), and analysed using ABI PRISM ® 3100 Genetic Analyser. We have identified 5 single nucleotide polymorphisms (SNPs) including 4 that have previously been identified in patients with chondrocalcinosis. These are in exon 2 (GCC†’GCT 294), intron 2 (G†’A +8), exon 8 (GCA†’GCG 963) and intron 8 (T†’G +15). We also identified an A†’G variant in 3′-UTR, 30 base pairs after the stop codon which has not been reported before in crystal deposition diseases, and is also not seen in any of the healthy controls. Further elucidation is necessary to demonstrate a causal relationship between these ANKH mutations and cuff tear arthropathy, which will add to our understanding of pathogenic mechanisms in this condition.


CP Roberts P Huysmans T Cresswell CJF Muller K Van Rooyen DF Du Toit J De Beer

The management of bony lesions associated with glenohumeral instability has been open to debate. Invariably a significant period of time elapses between injury and surgery during which the bony fragment may atrophy and reduce both in size and in quality. Histomorphometric bone analyses were prospectively performed on the glenoid bone fragments harvested during the modified Latarjet operation. The main purpose of the study was to assess the viability of the bone. Biopsies were obtained from 21 patients that had given informed consent. Median age was 21 years (range 16–50). All were male patients. The most important sports identified were rugby (64%) and water sports (surfing, water polo, water skiing, surfing (21%)). Mean glenoid bone loss on CT scan was 17% (range 10–50%). Thirty-three percent had bone loss greater than 20%. Gross morphology of glenolabral fragments identified a single large fragment (11/21); dominant large fragment plus smaller fragments (7/21); multiple fragments (4/21). Single large fragments comprised 52% of the study. Mean volume and mass of bony fragments were 2.18 ml (range 1–3 ml) and 1.64 gms (range 0.43–2.8 g), respectively. Histology of the specimens revealed no bone in three of the 21 specimens. Bony necrosis was present in 8/18 (44%) of the specimens. From a histopathological point of view, reattachment of these devitalized bone fragments by screws or anchors may result in predictable operative failure and recurrent instability. We can therefore not support the practice of “repair” of bony Bankart lesions based on the above findings.


S. Joshy A. Iossifidis

The aim of this study was to assess the accuracy of Magnetic Resonance Arthrography (MRA) in symptomatic shoulder joint instability. Data were collected prospectively from MR Arthrograms performed in 40 consecutive patients with recurrent symptomatic instability. MR Arthrograms included views in the stress ABER position of the shoulder. Subsequently all patients underwent an arthroscopic shoulder stabilisation and the arthroscopic and MR Arthrographic findings were correlated. In case of discrepancy the films and operative findings were reviewed.

There were thirty three male and seven female patients with a mean age of 28 years (range 18–40). MR Arthrography showed 37 anterior-inferior tears (22 displaced Bankart tears, 8 nondisplaced Bankart tears, 5 chronic ALPSA lesions and 2 AGL lesions) and 3 posterior lesions. There were 3 discrepancies of which 2 were cases of missed Bankart lesion on MRArthrogram and one case of reverse Perthes lesion present on MRArthrogram but not seen on arthroscopy. Despite a review of the films, the missed Bankart’s lesions were not visualised. In the present study, MR arthrography had a 95% sensitivity in detecting ligamentolabral pathology and a positive predictive value of 0.975 in diagnosing a lesion in recurrent shoulder instability.

The results show that MR Arthrogram is a highly useful tool for investigating recurrent shoulder instability with very high sensitivity and positive predictive value. Of the 40 patients who underwent arthroscopy there were only 2 cases where MR Arthrography did not demonstrate an arthroscopically detected abnormality.


Mr M. D. Brinsden Dr H. S. Gill Mr P. Reilly A. J. Carr Mr J. L. Rees

Background: Objective assessment of technical skill in orthopaedic surgery remains elusive. The general surgeons have validated a motion analysis model as a measurement of surgical ability for laparoscopic procedures. The aim of this study was to validate the motion analysis model in the context of simulated shoulder arthroscopy and use it to assess technical ability in a mixed population.

Methods: 35 volunteer subjects were recruited from the Oxford University Medical School and the Nuffield Orthopaedic Centre and stratified into groups according to their professional background. There were seven groups: consultant arthroscopic orthopaedic surgeons; senior orthopaedic SpRs (year 5/6); junior orthopaedic SpRs (year 1/2); basic surgical trainees; musculoskeletal physicians; graduate medical students; and hospital managers. Each subject completed a questionnaire to record previous arthroscopic experience and underwent psychometric testing. After receiving standardised instructions, each subject performed one diagnostic and one therapeutic procedure using the Alex Shoulder Professor (Sawbones Europe AB, Malmo, Sweden) model. The Patriot (Polhemus, Colchester, USA) electromagnetic tracking system was used to track hand movements during each procedure.

Results: We present the results of psychometric testing and motion analysis (time, distance and number of hand movements) data in subjects with a variety of experience of arthroscopic surgical techniques. We have demonstrated differences between the groups.

Conclusions: Objective assessment of arthroscopic surgical skills using motion analysis is valuable in identifying differing surgical abilities. We believe that this may help with the career development of trainees and in the development of specific teaching programmes for arthroscopic surgery.


M. Ravenscroft S Pai J DerTavitan I Trail

We report our experience of revision shoulder arthroplasty at Wrightington Hospital. Thirty-Nine patients had undergone revision surgery and followed up for a minimum of two years. Patients were scored using the Constant score and the ASES score pre-operatively and post operatively. All patients had X-ray evaluation for loosening and migration. Of the thirty-nine patients, 16 were failed humeral head replacement (HHR) and 16 were failed total shoulder replacement (TSR). All but two of the HHR were revised for glenoid erosion to a TSR, there was an equal proportion of patients with rheumatoid arthritis and osteoarthritis. Of the 16 patients undergoing revision surgery for failed TSR 6 were rheumatoid, 4 had osteoarthritis and 5 had posttraumatic arthritis. The main reasons for revision include glenoid loosening (7) instability (4) and peri-prosthetic fracture (2). The average constant scores post operatively for HHR and TSR were 35.5 (sd+/− 21.1) and 29.1 (sd+/− 12.1) respectively. The average ASES scores for HHR and TSR were 60.5(sd +/ 27.8) and 50.1(sd +/− 22.0) respectively. There was no statistical difference between the two groups in respect to the constant scores (p value 0.18) or ASES scores (p value 0.16). Overall, the pain relief was good post operatively following both HHR and TSR. The mean visual analogue score for pain following HHR was 3.2 and following TSR 3.5. Range of movement, function and strength was poor following both HHR and TSR.

HHR fail in a predictable way and can be revised with conversion to a TSR. TSR fail in a variety of ways and there revision surgery is demanding and complex. Both types of revision offer good pain relief but poor function.


A. R. McAndrew R. B. Simonis

Purpose of Study We present a method of treating these infected humeral shaft non-unions with an open debridement procedure followed by stabilisation with the Ilizarov frame.

Materials Thirteen infected non-unions of the humerus in adult patients have been treated by this method. Ten patients have completed their treatment and three are still undergoing treatment.

The site of the non-union is approached through the pre-existing scar and any remaining metalwork is removed. The ends of the non-union are mobilised and bone is resected from both ends until there is fresh bleeding. The two bone ends are fashioned such that one will fit as a spike inside the medullary cavity of the other. The bone ends are held in position with two temporary K wires until the frame has been applied.

A standard four ring Ilizarov frame is applied with Rancho pins in the proximal humerus and a half ring in the distal humerus. The temporary K wires are removed and the frame is compressed to increase the contact between the bone ends. The routine hospital stay is one week and the patients are given intravenous antibiotics throughout their admission.

They are reviewed in the outpatient clinic at monthly intervals and the frame is used to compress the bone ends by two to three millimetres on each visit. When there are radiographic signs of union the frame is removed under a general anaesthetic.

Results Nine of the ten patients who have completed their treatment have gone on to union in a mean of 8.25 months with a good functional result. Unfortunately three patients had transient radial nerve palsies.

Conclusions This technique has achieved union and eradication of infection in nine out of ten patients in whom all other forms of treatment had failed.


H.C. Brownlow

The purpose of this study was to test the null hypothesis that patients with partial thickness rotator cuff tears do not suffer more pain or stiffness than those with full thickness tears. A power study determined that 68 partial thickness tears were required in the study in order to prove a clinically important difference (± = 0.05 and 2 = 0.2). Consecutive patients undergoing arthroscopy and bursoscopy for rotator cuff related problems were assessed using a pain analogue scale and their shoulder movements were measured. Information was gained both pre- and intra-operatively about possibly relevant confounders including age, site size and thickness of tears, and endocrine disorders. Exclusion criteria included glenohumeral arthropathy, frozen shoulder, instability and major traumatic injuries, as well as the inability to understand the pain score. 439 shoulders (428 patients) were included in the study; 216 shoulders had no cuff tear, 95 had partial thickness tears (75 joint side, 1 intrasubstance, 19 bursal side), and 128 shoulders had full thickness tears. There was no significant difference (p< 0.05) in the pain scores or range of movement between full and partial thickness tears. Age was the only independent variable to have an effect on pain score.

The null hypothesis has been upheld. This study contradicts the findings of previous research and challenges commonly held assertions on this topic. Neither pain nor stiffness can be used clinically as discriminators between partial and full thickness rotator cuff tears.


D Chan D Philip A Mahon RYL Liow

Introduction We have evaluated the early outcome of arthroscopic excision of the distal clavicle (Mumford procedure) for acromioclavicular joint pathology.

Method Forty-one patients with acromioclavicular joint pathology underwent arthroscopic distal clavicle resections between 2002 and 2004. Preoperatively, all patients had acromioclavicular joint tenderness, 90% had a positive horizontal adduction test and 62% had a positive O’Brien’s AC compression test. All provocative signs were abolished on re-examination after acromio-clavicular joint injection. Surgery was indicated with failure of conservative management. Surgery was performed through a subacromial approach to the acromio-clavicular joint, using a Acromionizer (Smith-Nephew Dyonics, Andover, MA) burr through the anterosuperior portal. A supplementary Neviaser portal was used in 9 cases. Patients were clinically assessed at average of 18 months post surgery (range; 9–36). Functional rating was obtained with the Constant Score, WORC score and the Oxford Score. Results

Thirty-five patients (85%) reported none or minimal pain. 81% were negative for provocative AC signs. Internal rotation increased by average of 5 vertebrae levels. The Constant, the WORC and Oxford Scores were improved by 23 points, 674 points and 16 points respectively (p< 0.05). 71% reported good or excellent function by the 3rd post-operative month.

Conclusion The arthroscopic Mumford procedure effectively treats acromioclavicular joint pathology. The procedure has low associated morbidity and high patient satisfaction.


T.J.W. Matthews G.C.R. Hand J.L. Rees N.A. Athanasou A.J. Carr

The aim of this study was to observe cellular and vascular changes in different stages of full thickness rotator cuff tear.

Biopsies of the Supraspinatus tendon in 40 patients with chronic rotator cuff tears undergoing surgery were analysed using histological and contempary immunocytochemical techniques. Sections were stained with primary antibodies against PCNA (Proliferating cell nuclear antigen), CD34 (QBEnd 10), CD45 (Leucocyte Common Antigen), CD68, D2-40 (Lymphatic Endothelial Marker) and Mast Cell Tryptase. A histological analysis was performed with Mayer’s Haemotoxylin and Eosin, Congo Red and Toluidine Blue.

The reparative response and inflammatory component (figure 1) of the tissue was seen to diminish as the rotator cuff tear size increased. This was evidenced by increasing degeneration and oedema, reducing fibroblast proliferation, reduced thickening of the synovial membrane and reducing vascularity. Macrophage, other leucocyte and mast cell numbers also reduced as tear size increased. Large and massive tears revealed a higher degree of chondroid metaplasia and amyloid deposition when compared to smaller sized tears. There was no association with the patient’s age or duration of symptoms.

Small sized rotator cuff tears retain the greatest potential to heal and have a significant inflammatory component. Tissue from large and massive tears is of such a degenerate nature that it may never heal and this is probably a significant cause of re-rupture after surgical repair in this group. Selection of patients for reconstructive surgery should take into account the composition and healing potential of tendon tissue and its relationship to tear size in chronic tears of the rotator cuff.


A. Nisar M.W.J. Morris J. Freeman J. Cort P. Rayner S.A. Shahane

Background: Subacromial decompression surgery is associated with significant postoperative pain. We compared the effect of intrascalene block (ISB) and sub-acromial bursa block (SBB) with simple opiate based analgesia

Methods: In a prospective, randomised controlled trial, fifty-three (n = 53) patients scheduled for arthroscopic subacromial decompression were randomised into three groups receiving Intrascalene block (n =19), Subacromial Bursa block (n =19) or neither of the two blocks (n =15 controls). Patients with cuff pathology were excluded. ISB was performed preoperatively with 20 mls of 1% Prilocaine and 10 mls of 0.5 % Bupivacaine. SBB was given with 20 mls of 0.5% Bupivacaine postoperatively. All patients received standardised general anaesthetic and postoperative analgesia. Pain, sickness and sedation scores were noted at 1, 2, 4, 8, 12 and 24 hours postoperatively. The postoperative consumption of morphine and the time when the first bolus of morphine was required were also noted.

Results: The visual analogue pain scores in the ISB and SBB group were lower than the control group in the first twelve hours postoperatively achieving statistical significance but there were no significant differences between the SBB and ISB groups. The controls consumed more morphine postoperatively (mean 32.3 mls) than SBB (21.21 mls) and ISB groups (14.00 mls) (p < 0.001). The time for first bolus was earlier in the controls (mean 30.2 mins) as compared to both SBB (72.7 mins) and ISB groups (105.8 mins) (p< 0.001). The oral analgesic intake was less in the SBB and ISB groups than the controls (p = 0.004), but there was no difference between the two treatment groups.

Conclusion: Whilst intrascalene block remains the gold standard where expertise is available for its administration, subacromial bursa block is a safe alternative in patients with intact rotator cuff undergoing arthroscopic subacromial decompression.


Mr N A Quraishi Mr P Johnston Mr J Bayer Dr M Crowe Mr A Chakrabarti

This is a prospectively randomised blind study to determine which treatment- Manipulation under anaesthesia (MUA) or Hydrodilatation is more effective for proven shoulder adhesive capsulitis. Forty patients with adhesive capsulitis were randomised to receive either of the two treatments. All patients were assessed by an independent investigator, with Visual Analogue Scores (VAS) and Constant scores, at three intervals “ pre-treatment, 2 months and 6 months following treatment. Twenty patients (mean age 55.2 years (44–70); duration of symptoms 33.7 weeks (8–76)) received hydrodilatation and eighteen (mean age 54.5 years (39–69); duration of symptoms 43.5 weeks (12–102)) underwent MUA (two patients dropped out). VAS scores in the hydrodilatation group were pre treatment 6.1 (n=20), 2.4 (n=18;p=0.001) at 2 months and 1.7 (n=17; p=0.0006) at 6 months. VAS scores in the MUA group were pre treatment 5.7 (n=18), 4.7 (n=16) at 2 months, and 2.7 (n=15;p=0.0006) at 6 months. The VAS pain scores in the hydrodilatation group were significantly better than the MUA group over the six month follow-up (p< 0.0001)Constant scores in the hydrodilatation group were 30.8 pre treatment, 57.4 (p=0.0004) at 2 months and 65.9 (p=0.0005) at 6 months. In the MUA group, Constant scores were 38 pre treatment, 60.2 (p=0.001) at 2 months and 59.5 (p=0.0006) at 6 months. Constant scores in the hydrodilataion group were again significantly better than the MUA group over the six month follow-up (p= 0.02). At final follow up, 93% of patients were satisfied or very satisfied after hydrodilatation compared to 71% of those receiving an MUA.

We have for the first time prospectively measured the outcome of two treatments “ MUA and hydrodilatation in patients with adhesive capsulitis. Our results suggest that although both treatments are effective in the majority of patients, hydrodilatation is significantly more effective than a manipulation under anaesthesia.


A Richards S Ridgeway C Pearce RJ Sinnerton

To study the outcome of complex proximal humeral fracture sequelae (Type 3 & 4) treated with the Delta III Total Shoulder Replacement (TSR) Prosthesis. This is a prospective outcome study involving 10 patients mean age (71.5 yrs). All patients failed conservative treatment of proximal humeral fractures. Mean time from injury to surgery was 10.5 (+/− 11.5) months. All patients underwent a Delta III TSR via McKenzie approach by a single surgeon. Patients were assessed clinically with Constant scores, asked whether they were satisfied, and radiologically with plain film radiographs. Since last review one patient has died. Mean time at follow up was 20.8 months post-operation (12 “32 months). Three patients had undergone early revision for dislocation. Since last review two patients have developed deep infection, one treated with washout and suction drain, one with removal of prosthesis. One patient has a clinical diagnosis of complex regional pain syndrome. Three patients are very happy with the outcome of surgery, one is happy, one unhappy and four very unhappy. The mean pre-operative Constant scores was 8.9 (2–15), at first review 44.4 (15–96) and now 35.8 (4–76). The mean pain score on a visual analogue scale (0–10) was 3.6 (0–10). Radiographs showed no progressive notching of the glenoid in any patient. Mean flexion was 93 degrees (10,170), mean abduction 61 degrees (10,100) and mean external rotation was “1 degrees (−20,20).

This is a new technique for treating proximal humeral fracture sequelae. Some individual results are excellent. There has been a high complication rate and a significant rate of poor results. At this time we cannot recommend the reverse geometry prosthesis for the treatment of proximal humeral fracture sequelae.


S. Joshy A. Iossifidis K Khaled

This study was performed to evaluate the efficacy of interscalene block combined with general anaesthetic for common surgical procedures of shoulder and the potential of this procedure for providing day case shoulder surgery.

114 consecutive patients undergoing shoulder surgery were audited using a questionnaire immediately after operation and at 6, 12 and 48 hours after operation. Pain scores were recorded based on visual analogue scale, type of operation, duration of operation, postoperative stay and complications. At 48 hours overall pain control was assessed and patients were asked about having their operation done as a day case.

104 patientswho responded to the questionnaire were included in the study. There were 52 males and 52 females with overall mean age of 49 years (range 18–85). 75 patients underwent arthroscopic decompression, 15 patients underwent arthroscopy assisted mini open cuff repair, 9 underwent open glenohumeral stabilisation and the rest five underwent open Mumford procedure. Mean operation time was 47 minutes (range 25–90). 97 (93%) patients had no pain immediately postoperatively, 76 (73%) patients were pain free at 6 hours and 39 (38%) were pain free at 12 hours. Mean pain scores art 6 hours was 3 and at 12 hours were 4. 101 patients said their pain was well controlled throughout the first 48 hours by simple oral analgesics. 84 (83%) patients expressed an opinion that they could have been managed as day case provided they were adequately counselled about the procedure. 6(5.7 %)patients showed signs of Horner’s syndrome that resolved by 12 hours. No other complications related to inter scalene block occurred.

This study has shown that interscalene block is a safe procedure providing sustained adequate pain relief after shoulder surgery. It could allow a high percentage of patients undergoing shoulder surgery to be discharged home on the day of surgery.


A Pillai R Shenoy R Reid P Tansey

Introduction: Frozen shoulder is a general term denoting all causes of motion loss in the shoulder. As the syndrome is very common, many patients do not undergo detailed imaging studies before treatment.

Objectives: A series of 15 patients with primary neoplasms of the shoulder girdle mimicking frozen shoulder syndrome is presented.

Results: There were 6 male and 9 female patients. The common presentation was pain and stiffness of the shoulder joint. Mean age at diagnosis was 46.63Yrs (range 23 “ 71 Yrs). 73% were less than 50 Yrs of age. Only 2 gave history of trauma. Most received local steroids and physiotherapy before diagnosis. There were 10(66.6%) proximal humeral lesions and 5(33.3%) scapular lesions. Humeral lesions included chondrosarcoma (2), Ewing’s (2), lymphoma (2), chondroma (2) and osteoblastoma (1). Scapular lesions included chondrosarcoma (3), lymphoma (1) and fibromatosis (1). Scapular tumors involved older individuals. The mean delay in diagnosis after onset of symptoms was 15.8 mts (range 2 weeks- 48 months). All patients had X rays and CT / MRI. Treatment included a combination of surgery, chemotherapy and radiation. 3 patients with humeral lesions died at a mean of 20.6 mts, and 3 patients with scapular lesions died at a mean of 4.3 mts after diagnosis. The common cause of death was pulmonary metastasis.

Discussion: Many so called frozen shoulders are joints inhibited by pain rather than by true contracture. The commonest lesion to mimic a frozen shoulder is a slow growing low/middle grade chondrosarcoma. Young patients presenting with persistent pain or night pain must be examined for this possibility. Consideration should be given for further investigation before instituting treatment. Delay in diagnosis adversely affects survival. Surgeons are reminded that although rare, a tumor should be suspected when clinical presentations are unusual.


DJ Cloke H Watson S Purdy IN Steen JR Williams

The aim of this randomised, controlled trial is to compare subacromial steroid injections, physiotherapy and both interventions with a control treatment in early painful arc of the shoulder.

Over a six-month period patients with “painful arc”, of less than six months duration, were recruited via their GPs. Eligible patients were consented to enter the trial and were then randomised, by sealed envelopes, to one of four arms of the study: control (normal analgesia and/or non-steroidal anti-inflammatory medication), a specified and repeatable Exercise and Manual Therapy Package (EMTP), a course of up to three subacromial steroid injections or both the EMTP and the steroid injections. The interventions and clinic follow-ups were over an 18-week period. A final postal questionnaire was sent out at one year. The progress of the patients was monitored using the Oxford Shoulder Score (OSS) and the SF36 general health questionnaire.

Seventy-nine GPs referred 186 patients, of whom 112 were randomised (Control=27, EMTP=29, Injections=28, Both=28). 64 patients were female and 48 male. The mean age was 54.5 years (range 23–88 years). Ninety patients completed the trial (Control=20, EMTP=22, Injections=26, Both=22). Sixty-two returned the follow-up questionnaire. By paired sample t-tests, no significant differences were found between the OSS scores or SF-36 (physical health total) at the beginning and end of the intervention period, or at one year. Two patients in the injection group went on to surgery, along with one each in the control and EMTP groups.

We have found no significant differences in outcome between steroid injections, a physiotherapy package, both treatments, or symptomatic treatment in our group of patients presenting with symptoms of painful arc of the shoulder.


B. Venkateswaran A.S. Montgomery T. Zaman T. Even S. Copeland O. Levy

The purpose of this study is to report the 1 to 5 year results of arthroscopic Rotator Cuff repairs.

Between November 2001 to May 2003, 115 consecutive patients were operated (73 males and 42 females) with arthroscopic repair. 13 patients were lost to follow up, leaving 102 patients available for follow up. Patients were evaluated using the Constant score, satisfaction levels and ultrasound scan to evaluate cuff integrity. Failures were defined as dissatisfied patients and those who had had a re-operation. Re-tear rate was recorded.

The mean follow up time was 23.8 months (range 12–61). Mean age was 57.3 years (range 23–78). 47% had a history of trauma. There were 107 patients (95.5%) with full thickness tears and 5 (4.5%) had partial thickness tears. Of the full thickness tears, 8 (7.6%) were massive in size, 36 (34%) large, 44 (41.5%) medium and 18(17%) small. Isolated Supraspinatus (SSP) tear was recorded in 83.5% and subscapularis tear in 7 %. A combination of SSP tear with infraspinatus and teres minor was found in 9.6%.

86% had Acromioplasty (ASD) with or without an AC joint excision arthroplasty. Two patients had Bankart repairs in addition at the time of cuff repair.

The mean pre op Constant score was 40.9 points (95% CI 37.3 to 44.5), which had improved to 84.8 (CI 82.2 to 86.9) at last follow-up. 78% returned to same work and 82% returned to pre injury leisure activity. There were 20 re-tears (19.6%). eight of the 102 patients were not satisfied. Five of these patients had revision operation.

Arthroscopic cuff repair shows high satisfaction rate (92%) and good functional results with 20% re-tear rate, while offering all the advantages of arthroscopic surgery.


N K Anjarwalla R K Morcom R D Fraser

Objectives: The purpose of this study was to assess the effect of different types of posterior stabilisation on the fusion rate of anterior lumbar interbody fusion (ALIF)

Thin section CT scanning has shown a higher rate of pseudarthrosis with ALIF than previously reported with standard radiological modalities. Cadaveric studies have demonstrated that posterior stabilisation would increase stiffness of the motion segment and is likely to enhance the rate of fusion with ALIF. The results of thin section CT scanning of ALIF, with and without posterior stabilisation, has not been reported previously.

Methods: Patients with discogenic back pain confirmed by discography underwent ALIF surgery as a stand alone procedure or with posterior stabilisation – using trans-laminar screws, unilateral pedicle screws or bilateral pedicle screws. Patients were followed up prospectively and thin section CT scanning was used to assess inter-body fusion.

Results: The fusion rate for stand alone ALIF was 51%, for patients with supplementary stabilisation with trans-laminar screws 58%, with unilateral pedicle screws 89% and with bilateral pedicle screws 88%. When ALIF was combined with pedicle screw stabilisation a significant difference in the fusion rate was found (p< 0.01).

Conclusion: The addition of pedicle screw fixation at the time of ALIF produces a significant increase in the rate of interbody fusion.


AH McGregor AK Burton G Waddell P Sell

Background/purpose: Clinical outcomes of surgery for disc herniation and spinal stenosis are variable. Surveys show that post-operative management is inconsistent, and spinal surgeons and their patients are uncertain about what best to do during the recovery phase. The aim of this study was to develop a patient-centred, evidence-based booklet that spinal surgeons can give to their patients to reduce uncertainty, guide post-operative management and facilitate recovery.

Methods: A systematic literature search led to a best-evidence synthesis of appropriate information and advice on post-operative activation, restrictions, rehabilitation, and expectations about surgical and functional outcomes. Data were extracted into evidence statements which were graded by consensus for consistency and practicality so as to inform and prioritise the booklet’s messages. Following peer review (n = 16), a sample of patients (n = 11) gave a structured evaluation of the draft text.

Results: The review found scant evidence in favour of post-operative activity restriction, yet an early active approach to post-operative rehabilitation can improve clinical, functional and occupational outcomes. Thus, the text of the booklet presents carefully selected messages to reduce uncertainty, promote positive beliefs, encourage early reactivation, and provide practical advice to aid self-management. Peer reviewers’ comments were incorporated into the text; all the spinal surgeons (n = 7) said they would find the booklet useful. Patients found it readable, interesting and helpful; they understood and accepted the intended messages.

Conclusions: Following careful development, an evidence-based booklet to aid post-operative management in spinal surgery is now available, and is factored into a RCT of post-surgical rehabilitation.


M Underwood

Objective: To explore the views of patients’ differing treatments received within a randomised controlled trial of physical treatments for low back pain.

Methods: Within a randomised controlled trial, that found small to moderate benefits from adding a manipulation package or an exercise programme to General Practice care, we elicited participants’ views on their treatment from free text responses to an open question completed by respondents at the end of baseline and follow-up questionnaires. These data were organised and analysed using an adapted ‘Framework’ approach.

Results: We received a total of 1,259 comments from 1,334 participants. Participants randomised to general practice care reported dissatisfaction with only receiving ‘usual care’ that consisted of no more that providing analgesic medication without providing an explanation for their pain. Those randomised to a manipulation package felt the intervention was appropriate to their needs, commonly reporting quite striking benefits. Participants assigned to the exercise programme developed a sense of self reliance in managing back pain although some failed to be sufficiently motivated to continue their exercise regimen outside of the classes.

Conclusions: This qualitative analysis has found much more dramatic differences between the groups than the main quantitative analysis. This suggests that some of the ‘value added’ to general practice care from being allocated to additional physical treatment for low back pain is not being captured by existing methods of measurement. Improved methods of assessment that consider a wider range of domains may be needed when interpreting the added value to individual patients of such treatments.


RK Trehan J Chan G Helipern I Packham G Marsh A Knibb

Objective: This is a prospective, randomised, double blind trial to assess the effectiveness of intrathecal fentanyl in the relief of post-operative pain in patients undergoing lumbar spine surgery.

Method: 60 patients were recruited. All received our standard analgesic regime with morphine PCA via a syringe driver. They were electronically randomised to two groups – one received 15 micrograms of fentanyl intathecally; the other had nothing. The fentanyl was administered by the operating surgeon under direct vision at the end of the procedure.

All patients were monitored in recovery for two hours. Visual Analogue Scale (VAS) pain scores were assessed at 2, 4, 24 and 48 hours post-op. The time to first bolus delivery of PCA was recorded as was the total amount of morphine PCA used. Both patient and assessor were blinded.

Results: The patients randomised to receive fentanyl showed a significant decrease in their mean VAS pain scores for the first 24 hours. Their time to first bolus of PCA was significantly increased. They also used 40% less morphine PCA (p< 0.05 in all cases). None of the patients suffered respiratory compromise requiring treatment and they all left recovery after 2 hours to be nursed on the general ward.

Conclusion: Intrathecal fentanyl is effective at reducing post-operative pain and PCA morphine use after lumbar spinal surgery. We support its use over morphine because of the reduced incidence of respiratory complications and the ability to nurse patients on a general ward.


RE Johnson C Roberts GT Jones NJ Wiles C Chaddock RG Potter P Watson DPMS Symmons GJ Macfarlane

Background: Each year, 7% of the adult population consult their General Practitioner (GP) with low back pain (LBP). Approximately half of these patients still experience disabling pain after three months. Evidence suggests a biopsychosocial approach may be effective at reducing long-term pain and disability. This study aimed to evaluate, for persistent disabling LBP, the effectiveness of an exercise, education and cognitive behavioural therapy intervention compared to usual GP care plus educational material, and to investigate the effect of patient preference.

Method: Design: randomised controlled trial. Patients, aged 18–65yrs, consulting their GP with LBP were recruited. After 3 months those still reporting disabling LBP (≥20mm on 100mm pain visual analogue scale (VAS) and ≥5 Roland and Morris Disability Questionnaire (RMDQ) points) were randomised, having first established preference, to 2 groups. VAS and RMDQ were assessed at 0, 6, and 12-months post-intervention.

Results: 234 patients were randomised; 116 to the intervention. The intervention showed small non-significant effects at reducing pain (3.6mm) and disability (0.6points RMDQ) over one year. Preference showed significant interaction with treatment effect at one-year; patients had better outcomes if they received their preferred treatment.

Conclusion: The above intervention program produces only a modest effect in reducing LBP and disability over a one-year period. These results add to accumulating evidence that interventions for LBP produce, at best, only moderate benefits. The challenge for future research is to evaluate interventions tailored for specific LBP sub-populations. These results suggest that if patients receive treatment which they believe is beneficial their outcome can be optimised.


IF IT HURTS- MOVE IT! Pages 218 - 218
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G M Knox J R Wiles T P Nash

Purpose and Background: A clinical scenario and questionnaire was used to examine how back pain advice may be influenced by a clinician’s interpretation of an investigation and by their pre-existing beliefs about pain.

Methods: All pain clinics in the Dr. Foster report and a randomized sample of 200 General Practitioners were sent a questionnaire based on a presenting 42 yr old male patient with chronic back pain but no sciatica. An MR scan shows “degenerative changes in the L4/L5 discs, both of which are narrowed and dehydrated. A disc tear can be seen at L4/5 with a small central prolapsed disc. There is no evidence of any significant thecal or root compression.”

The questionnaire comprised statements paired with a 7-point scale, ranging from 0 (do not agree) to 6 (completely agree), therefore respondents marking 0–2 would be disagreeing, and those marking 4–6 would be agreeing with that statement.

97/109 (90%) respondents agreed the patient could continue to live normally, 38 (35%) would say the scan is essentially normal and 51 (47%) would not. 21/109 (19%) would say the scan is significantly abnormal and were likely to give restrictive movement advice (13/21 v 26/88: p=0.01). Clinicians who advise against painful movements were likely to seek a surgical opinion (19/32 v 13/77: p< 0.0001)

Conclusions: Clinicians advising against painful movements are highly likely to seek surgical opinions for back pain and those who interpret an investigation as abnormal are likely to give restrictive movement advice. Clinician education in back pain should take account of these findings.


S N Casserley-Feeney G Bury L Daly D Hurley

Background: In the Republic of Ireland, physiotherapy for low back pain (LBP) is delivered in both public and private sectors via hospital-based departments (H) and community-based private practices (P) respectively. However, there is inequity in access and minimal evidence of the physiotherapy management of LBP in these two settings.

Purpose: To investigate any differences in patient profile and physiotherapy management of LBP in H and P settings.

Methods: A random sample of one Dublin city hospital and neighbouring private practices (n=3) were recruited. A retrospective chart survey of all LBP patients who commenced physiotherapy during 2003 was conducted. Data were analysed using Statistical Package for Social Sciences (SPSS, v.11). Ethical approval was granted by the participating hospital.

Results: In total, 249 charts were identified: H=93 [male n=32, female n=61, mean age (SD) = 46 years (20)]; P =156 [male n=78, female n=78, mean age (SD) = 36 years (10)]. Statistically significant differences between settings were found for:

percentage of patients with ‘acute’ (< 12 weeks) and ‘chronic’ (≥12 weeks) LBP [H: acute LBP = 4.7%, chronic LBP = 95.3%; P: acute LBP= 84.7%, chronic LBP= 15.3%; χ2 = 120.34, df=1, p< 0.001];

mean number of treatments [H=5 treatments (SD=3.8); P=2.5 treatments (SD=2); t = −6.0, df = 123, p< 0.0001];

median duration of treatment [H=6 weeks (IRQ=4-12); P=1 week (IRQ=0.14-2) p< 0.0001].

Conclusion: Findings suggest a two-tier system of health care for LBP patients in Ireland. A randomised controlled trial evaluating patient outcomes in both settings is currently underway by the Research Team.


AA Harte GD Baxter JH Gracey

Background and purpose: Lumbar traction is a common treatment for LBP with radiculopathy. Despite this, its benefits remain to be established. This paradox has significant economic and therapeutic consequences as 3–10% of patients with LBP in the UK have radiculopathy and over 40% of UK physiotherapists use this approach (Harte et al 2005). The purpose of this pragmatic randomised clinical trial was to assess the benefit of lumbar traction in addition to a manipulation package with these patients in a manner that reflects clinical practice.

Methods: 30 patients meeting the inclusion criteria for lumbosacral radiculopathy were recruited from the NHS and randomly assigned to one of two treatment groups: Group 1 received manipulation, advice and exercises; Group 2 received traction, manipulation, advice and exercises. Outcome measures were recorded at baseline, completion of treatment and at 3 and 6 months post completion of treatment (MPQ, RMDQ, SF36, and the ALBPSQ). In addition VAS scores for back and leg pain and the percentage of overall improvement (patients perception) were recorded after each treatment.

Results: 30 patients were recruited over an 11-month period: 40% male, mean age 44 years, mean duration of current episode 7 weeks. Post treatment results (n = 27) showed a significant improvement in all outcomes for both groups (paired t-test, p > .01) but there was no significant difference demonstrated between groups (ANCOVA).

Conclusion: This pilot study demonstrates the feasibility of a trial with this sub-group of LBP patients and a large multi-centred trial would need to be conducted to fully address this research question.


J A Bell M Stigant

Background: Researchers have measured exposure to sitting using self-reported questionnaires and observational analysis. Such methods are not a reliable measure of daily exposure or sensitive enough to take into account lumbar posture when seated. Recent innovations have produced a fibre-optic goniometer (FOG) that can continuously measure sagittal lumbar posture, although this single sensor is unable to identify if the user is sitting, standing or walking.

Methods: A new system was developed utilising a second FOG attached to the hip. Movement characteristics of the hip and lumbar spine were described and used to develop software to predict activity (sitting, standing, walking). Subsequently 10 participants were asked to wear the FOGs for 8 minutes whilst their behaviour was recorded using a video camera. MPEG video sequences were produced and each activity was coded at a point in time and compared against the 2 FOG software model.

Results: All Participants found the system comfortable to wear. Validation of the software against the MPEG files showed high sensitivity for sitting (90%), standing (98%), and walking (95%). Positive predictive value was high for sitting (93%), standing (89%) and walking (94%). The overall agreement between video analysis and the FOG software was 92%

Conclusions: Developing the FOG has produced a practical system capable of continuously measuring sedentary workers basic activity in terms of sitting standing and walking. This novel tool will now be used in a prospective study of sedentary workers to determine the influence of seated lumbar posture on the development of LBP.


T Vemmer R Shankar R Hill S Dolin

Lumbar facet joint pain cannot be reliably diagnosed clinically, the International Spinal Injection Society recommends two diagnostic local anaesthetic blocks before radiofrequency (RF) denervation [1].

Scoring systems may improve diagnostic accuracy. The two most popular scores disagree on the interpretation of pain induced by extension/rotation:

‘Cochin Criteria’ [2]: pain on extension/rotation _ not facet joint problem

Helbig & Lee [3]: pain on extension/rotation _ facet joint problem

Methods: Retrospective study of all patients who had RF denervations of the lumbar facet joints in 2004.

Patients were selected clinically and did not undergo diagnostic blocks.

Cochin criteria, Helbig & Lee scores, work status, and outcome were taken from the case notes.

Likelihood ratios were calculated for the scores, their individual components, and work status.

Results: 145 patients underwent RF facet joint denervation, for 127 all data was available. In 68 patients the procedure was successful (53.5%).

Conclusion: Neither the Cochin Criteria nor the Helbig & Lee score can predict the response to radiofrequency denervation of the lumbar facet joints.

Pain on extension/rotation weakly indicates a poor response to facet joint denervation.

X-rays do not help with the diagnosis.

Social factors may be more important than clinical signs.


Full Access
L C Roberts S Fraser E Murphy

Purpose: ‘Red flags’ are patient responses and findings on history taking and physical examination that are associated with an increased risk of serious spinal disorders. The purpose of this paper is to identify red flags reported in the low back pain literature, establish consensus on whether (or not) they are considered red flags, and review the evidence for these signs and symptoms.

Methods: The following databases were searched using key words ‘red flag’ and ‘low back pain’:

MEDLINE (1951→)

EMBASE (1974→)

CINAHL (1982→)

PsycINFO (1806→)

AMED (1985→)

PEDro.

In addition, national guidelines and key texts were hand-searched. Each red flag identified in the literature was classified using The Guidelines Development Group’s format (where 100% coverage = ‘unanimity’; 75–99% = ‘consensus’; 51–74% = ‘majority view’; and 0–50% = ‘no consensus’), and the findings summarized.

Results: The electronic searches revealed 54 papers, with the resultant ‘red flags’ ranging from ‘no consensus’ to ‘unanimity’. Evidence for these signs and symptoms is variable. Case reports and series justify labelling some features ‘red flags’, whilst others owe their label to clinical experience and expert opinion.

Conclusion: Case reports and series should be reported/ published to help identify those signs and symptoms suggestive of serious spinal disorders and those more likely to be ‘red herrings’. Despite their importance, there is inconsistency within the literature in identifying true red flags and, an ability to identify these signs and symptoms is essential for all who practise spinal assessments.


K Deogaonkar B Kerr A Harris C Hughes S Roberts S Eisenstein R Evans C Dent B Caterson

Introduction: Several small leucine-rich proteoglycans (SLRPs) are involved in the regulation of collagen fibril size(s) in a variety of different soft and hard musculosk-eletal tissues. In the intervertebral disc (IvD) the major SLRPs involved in regulation of types I & II collagen fibril size are believed to be decorin, fibromodulin and lumican. Research into IvD degeneration and backpain is hampered by a lack of specific biomarkers to detect and monitor the disease process. We have discovered that two keratan sulphate (KS) substituted members of the SLRP family, Keratocan and Lumican (that are major KS-pro-teoglycans found in cornea) were unusually expressed in extracts from degenerative disc tissues.

Methods: Non-degenerate disc tissue (n=10) was obtained from 2 scoliosis patients and degenerate disc tissue from 11 patients undergoing surgery. The degenerate discs were graded using criteria described by Pfir-rman et al (Spine26: 1873; 2001). Tissue samples were extracted with 4M guanidine HCl and after dialysis subjected to SDS-PAGE and Western blot analyses using monoclonal antibodies that recognise epitopes on kera-tocan and lumican.

Results & Discussion: Keratocan was not found in the non-degenerate disc tissue but was present in all degenerate IvD tissues tested. Lumican showed and increased expression in extracts of degenative IvD tissues. Our working hypothesis is that the increased expression of these two SLRPs in degenerative disc tissue results from a reparative depostion of a type I collagen fibrillar ‘scar’. This unusual expression suggests their potential as biomarkers for detecting the onset of degenrative disc disease.


JC Hill KM Dunn R Mullis M Lewis CJ Main EM Hay

Background: Patients with LBP, ‘at risk’ of persistent symptoms, require targeted treatment in primary care. We have therefore developed and validated a new screening tool to classify these patients into appropriate management groups.

Methods: A list of LBP prognostic indicators was compiled by reviewing published studies and analysing existing datasets. Indicators were selected for the tool according to face and construct validity, consistency and strength of association. For each indicator outcome measure (e.g. Pain Catastrophising Scale) an individual question (e.g. ‘I feel that my back pain is terrible and that it is never going to get an better’) was selected for inclusion (ROC analysis). The tool was modelled to classify patients into 3 categories of risk. The screening tool and corresponding complete scales were mailed to 244 consecutive primary care LBP consulters. Individual items were validated against complete scales. Reliability was examined on 53 responders.

Results: This new screening tool classifies patients using 9-items to cover 8 key prognostic indicators. The questionnaires returned by 131 consulters demonstrated excellent construct validity for all individual items. 33% of patients were classified as ‘high risk’ (psychosocial and physical factors), 44% ‘intermediate risk’ (physical factors alone) and 23% ‘low risk’. Discrimination between groups across relevant constructs such as pain, disability, days off work and psychological distress was highly significant. Test-retest reliability was moderate (kappa = 0.54).

Conclusions: A novel LBP screening tool has been validated in primary care and effectively classifies patients ‘at risk’ of persistent symptoms. This will facilitate appropriate targeting of treatment.


R Niemeläinen T Videman M C Battié

Background and Purpose: Epidemiologic studies of low-back and neck pain are abundant, but research on mid-back pain is scant. No studies reporting the characteristics of mid-back pain in the general population were found. This study reports the one-year prevalence, severity, frequency and associated disability of mid-back pain, and compares these findings to those of neck and low-back pain.

Methods and Results: Male twins aged 35–70 years (n=600), from a general population sample, were interviewed with standardized questions. Stata’s survey methods were used to adjust for any correlation between the twins. The one-year prevalence of mid-back pain was 17.0% (95% CI 14.3–19.7) compared to 64.0% (95% CI 60.6–67.5) for neck and 66.8% (95% CI 63.4–70.3) for low-back pain. Among those reporting spinal pain, 55.1% with neck pain experienced frequent symptoms (daily to monthly), as compared to 33.3% with mid-back and 39.9% with low-back pain. The mean severity of the worst pain episode was highest for low-back pain, followed by neck and mid-back pain. Associated disability tended to be less common from mid-back pain (23.5%) than low-back (41.1%), with neck pain intermediate (30.3%). Mid-back pain was associated with higher likelihood of low-back and neck pain. Odds ratios for reporting neck and low-back pain were 2.32 (95% CI 1.53–3.51) and 2.86 (95% CI 1.80–4.54) higher, respectively, when mid-back pain was reported than when not.

Conclusion: The one-year prevalence of mid-back pain is approximately one-quarter that of neck or low-back pain, with associated disability tending to be less common. Other spinal co-morbidity is nearly always reported in cases of mid-back pain.


S. Kobayashi J.P.G. Urban A Meir K. Takeno K. Negoro H. Baba

Purpose: The inflammatory response around herniated tissue in the epidural space is believed to play a major role in the spontaneous regression of herniated lumbar disc. Numerous macrophages invade the herniated tissue along with newly formed blood vessels which influence oxygen gradient. Inflammatory cytokines such as interleukin-1 are produced by macrophages. These chemical mediators could stimulate disc cells to produce proteases such as MMPs which degrade the intervertebral disc matrix and could hence influence regression of the herniation. Here we have examined the influence of IL-1β and oxygen tension on proteoglycan turnover using a three-dimensional disc-cell culture system.

Methods: Cells were isolated from the nucleus pulposus of 18–24 month bovine caudal discs by enzyme digestion. They were initially cultured for 14 days in alginate beads in DMEM containing 6% FBS at 4.106 cells/ml under 21% oxygen to accumulate matrix. They were then cultured for 6 days under 0% or 21% oxygen and with or without IL-1β. Glycosaminoglycan (GAG) accumulation (as a measure of proteoglycan content) was measured using a DMB assay. Lactate and glucose production were measured using a standard enzymatic method. Rates of sulfated GAG synthesis was measured from rates of 35S-sulfate accumulation. MMP activity was measured using coumarin fluorescent assay.

Results: The results showed that IL-1β had a significant effect on GAG accumulation and production and that its effect was dependent on oxygen tension. GAG production and sulfate incorporation rates decreased in the presence of IL-1β at high oxygen but low oxygen inhibited the effects of this cytokine. MMP activity increased with IL-1β under 21% oxygen, but not at low oxygen.

Conclusion: Exogenous IL-1β can activate MMP activity and digest the extracellular matrix of the disc but only at high oxygen tensions. Angiogenesis as well as inflammation is thus required for resorption of herniations.


P Pollintine P Dolan GK Wakely MA Adams

Introduction: Osteoporotic fractures in elderly people are usually attributed to hormonal changes and inactivity. But why should the anterior vertebral body be affected so often?

Materials and Methods: Forty-one cadaveric thoraco-lumbar motion segments aged 62–94 yrs were loaded to simulate upright and flexed postures. A pressure transducer was used to measure “stress” inside the disc, and calculations showed how compressive loading was distributed between the neural arch, and the anterior and posterior halves of the vertebral body. Compressive strength was measured in flexed posture. Regional volumetric bone mineral density (BMD) and histomorpho-metric parameters were measured.

Results: Upright posture. Compressive load-bearing by the neural arch increased with grade of disc degeneration, averaging 52+25% in specimens with grade 3 or 4 discs. In these same specimens, the anterior half of the vertebral body resisted only 16+18% of the applied load. Relative unloading of the anterior vertebral body was associated with low BMD and with histomorphometric evidence of inferior bone quality. Flexed posture. Flexion always transferred loading to the anterior half of the vertebral body, so that it resisted 55+17% in specimens with grade 3/4 discs. Compressive strength measured in this posture was most closely proportional to BMD in the anterior vertebral body (r2 = 0.75), and inversely proportional to neural arch load-bearing in the upright posture (r2 = 0.39).

Conclusion: Disc degeneration causes the anterior vertebral body to be unloaded in habitual upright postures, reducing bone density and quality within it. This predisposes to wedge fracture when the spine is flexed.


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Z. Li O Boubriak Z Cui A Recklies J P G Urban

Purpose: High levels of the chitinase 3-like protein HC-gp39 (human cartilage glycoprotein 39) have been found in the synovial fluid and sera of patients with arthritis. Although the function of this protein is unclear, in chondrocytes at least it appears to limit catabolic responses to cytokines such as Il-1b. Here we have investigated secretion of this protein by intervertebral disc cells and determined if its production is influenced by extracellular osmolarity.

Methods: Cells were isolated from bovine caudal discs by enzyme digestion and cultured in DMEM in alginate beads for 6 days. Medium osmolarity was increased in the physiological range by sodium/potassium addition. Supernatants were collected every 2 days and replaced with fresh media. At the end of experiment the supernatants were used for lactate determination and for detection of GP-39 by western blotting. Beads were assayed for glycosaminoglycans, cell viability and cell density.

Results: GP-39 was a major protein secreted by disc cells. It was evident on day 2 at low osmolarities. By day 4 concentrations in the medium had increased significantly and the protein was present mainly in fragmented form, particularly at high osmolarities. Osmolarity had no effect on cell density or viability. Rates of lactate production and GAG accumulation were greatest at high osmolarities.

Discussion: Changes in osmolarity, equivalent to those experienced by disc cells during the diurnal loss and regain of fluid content, had significant effects on cell metabolism and influenced production of GP-39. Osmotic changes might thus influence responses of disc cells to inflammatory signals.


K. Takeno S. Kobayashi K. Negoro H. Baba J.P.G. Urban

Purpose: Proteoglycan loss is one of the first signs of disc degeneration. There is increasing interest in developing biological methods for its replacement both by in vivo repair and through tissue engineered constructs. Many factors influence the rate of proteoglycan accumulation. In this study, we examine how physiological levels of extracellular osmolality and oxygen tension influence proteoglycan accumulation in nucleus pulposus cells in a three-dimensional culture system.

Methods: Cells were isolated from the nucleus pulposus of 18–24 month bovine caudal discs. They were cultured for 6 days in alginate beads at 4 million cells/ml in DMEM containing 6% FBS under 0%, 5% and 21% O2, Medium osmolality was altered by NaCl addition over the range 270–570 mOsm. Cell viability was determined by manual counting using trypan blue. Lactate production was measured enzymatically and glycosaminoglycan (GAG) accumulation was measured using a DMB assay.

Results: There was no difference in the cell viability. Lactate production decreased under hypo- (270 mOsm) after 6 days in culture. After 6 days GAG accumulation was maximal in beads cultured at 5% O2 in 370 mOsm where GAG accumulation was 86.1% greater than at 21% O2 and DMEM at standard Osmolarity (270 mOsm).

CONCLUSION: In our model the prevailing osmolality was a powerful regulator of GAG accumulation by cultured nucleus cells. In vivo prevailing osmolality is governed by GAG concentration. These results thus indicate GAG synthesis rates are regulated by GAG concentration, with implications both for the aetiology of degeneration and for tissue engineering.


J Yu N Eisenstein Y Cui J C T Fairbank S Roberts J P G Urban

Introduction: Elastin is a structural protein forming a highly organised network in the annulus and nucleus of the intervertebral disc (IVD). It appears important in maintaining annulus structure as it is densely located in the interlamellar space and forms cross-bridges between lamellae. Here we have investigated elastin fibre organisation in degenerate discs and compared it to that seen in normal human and bovine discs.

Methods: Human lumbar IVD were obtained from consented patients undergoing surgery either for disc degeneration, tumour or trauma. The disc segments were collected from operating theatre and graded. A radial profile of the specimen was dissected and snap-frozen. Sections of 20μm in thickness were cut with a cryostat microtome and mounted on slides. To visualize elastin fibres, sections were digested with hyaluronidase after fixation with 10% of formalin. Elastin fibres were immunostained and fibre organisation mapped.

Results: In degenerate disc, the elastin fibre network appeared sparse and disorganised in comparison to that seen in non-degenerate human or in bovine discs in which elastin fibres are well organised. In addition, in degenerate discs the elastin fibres appear fragmented. Fragmentation of the elastin network within lamellae of the annulus in particular increased with both degeneration grade and with age.

Discussion: The loss of elastic network integrity observed in degenerate discs could contribute to loss of annulus integrity and affect disc mechanical properties adversely. Furthermore, our initial results have suggested fragmented elastin degradation products could upregulate MMP expression by disc cells thus stimulating a degenerative cascade.


D Skrzypiec P Pollintine A S Przybyla M A Adams

Introduction: There are extensive differences in structure and composition between cervical and thoracolumbar discs, yet practically nothing is known about the time-dependent “creep” behaviour of cervical discs.

Methods: 41 cadaveric cervical motion segments aged 48–89 yrs were subjected to a static compressive load of 150N for 2 hrs. Specimen height was recorded by the displacement of the actuator of the testing machine. Digitized radiographs were analysed to obtain dimensions of the vertebrae and discs. A three-parameter solid viscoelastic model was fitted to experimental data using nonlinear regression. Model parameters represent compressive stiffness of the wet tissue (E2) and of the drained solid matrix (E1), and tissue viscosity (η1).

Results:Model and experimental data were in good agreement (r2> 0.98) and the average absolute error was always < 2%. E1 was 11% and 39% lower than published values for thoracic and lumbar discs, respectively, whereas E2 was 43% and 53% higher. The ratio E2/E1 for cervical discs (1.63) was greater than for thoracic (1.01) and lumbar (0.66) discs. η1 for cervical discs was 108% and 21% higher than in thoracic and lumbar discs, resulting in a creep rate (E11) which was lower by 51% and 43% respectively. Comparisons between younger (mean age 58 yrs) and older (79 yrs) cervical discs showed that in the latter, η1 was reduced by 32% (p=0.01), E2 reduced by 18% (p=0.06), whereas E11 was increased by 47% (p=0.02).

Discussion: Cervical discs appear to resist water loss more than thoracolumbar discs, but this resistance falls in old age.


DW Evans NE Foster S Vogel AC Breen M Underwood T Pincus

Background: The three professional groups of chiropractic, osteopathy and musculoskeletal physiotherapy are involved in the management of 15–20% of all people with low back pain (LBP) in the UK. Exploratory and descriptive research suggests that the management of non-specific LBP by some members of these groups does not follow best available evidence.

Purpose: To test the short-term effectiveness of a directly-posted, contextualised, printed educational package about the evidence-based management of acute LBP on changing UK chiropractors’, osteopaths’ and musculoskeletal physiotherapists’:

reported practice (based on a vignette of a patient with non-specific LBP)

beliefs and attitudes about LBP(using the HC-PAIRS, Rainville et al 1995)

Methods: A prospective, pragmatic randomised trial was designed to test the effectiveness of the printed educational package versus a no-intervention control. Questionnaires were posted to simple random samples of UK registered chiropractors (n=611), osteopaths (n=1368) and physiotherapists (n=1625). Intervention packages were sent to consenting practitioners in March 2004, and follow-up questionnaires were sent 6 months later.

Results: Good response rates to the baseline questionnaire were obtained, and most respondents were willing to participate in the RCT. Following exclusions based on criteria determined a priori, 1758/3380 (52.0%) consenting practitioners were recruited for the RCT: chiropractors 335/601 (55.7%), osteopaths 600/1335 (44.9%) and physiotherapists 823/1444 (57.0%). Overall response to the 6 month follow-up was 1557/1758 (88.6%): chiropractors 280/335 (83.6%), osteopaths 520/600 (86.7%) and physiotherapists 757/823 (92.0%).

Conclusions: Data analysis is now being carried out. The main trial results will be presented at the meeting.


E Karadimas M Siddiqui M Nicol W Bashir T Mushakumar F Smith D Wardlaw

Purposes Of The Study-Background Data: Dynesys is claimed that allows motion in the operative levels. This study measures the changes in the lumbar spine in different postures, pre- and after insertion of the device.

Thirty patients with were treated with Dynesys system. All had discography and positional MRI preoperatively and nine months post-operatively.

The patients were divided in to two groups. The first in which only Dynesys was used and the second in which Dynesys was used with fusion.

Results: The operated levels were 63. The results of the pMRI measurements showed that the range of movement(ROM) of the L1/S1 angle in group-A reduced by 11.89o{pre-op=39.26o,postop=27.37o(p=0.008)} while in group-B reduced by 13.73o {preop=36.18o,po stop=22.45o(p=0.002)}.

The ROM of the end plate angle at the instrumented segments in group-A reduced from 5.24o to 2.18o{difference 3.06o(p< 0.005)} and in group-B reduced from 6.69o to 2.46o,{difference 4.23o(p=0.008)}. The ROM of the end plate angle at adjacent level in group-A changed from 8.26o to 7.0o {reduction 1.26o(p=0.388)},while in group-B increased from 6.91o to 8.64o, {difference 1.73o(p=0.149)}

The mean anterior disc height in-group A reduced by 1.43mm (p< 0.005) from 9.75mm to 8.32mm, and the posterior one was increased from 6.27mm to 6.77mm {difference of 0.5mm,(p=0.008)}. In group-B the anterior disc height reduced by 1.11mm (pre-op=10.44mm,post-op= 9.33mm,p=0.049) and the posterior one by 0.16mm (pre-op 6.98mm to post-op 6.82mm,p=0.714).

Conclusion: This study shows that in the Dynesys stabilizing system allows small range of movement at the instrumented levels, with no significant increased mobility in the adjacent levels. Also the device acted to compress the anterior annulus.


R Brecon A I Heusch P W McCarthy

Background and purpose: There have been a number of surveys of adolescents that have considered the incidence of back pain and its relation to backpack use and carry load. However, none have considered whether the problem can be directly related to school term and associated extra-curricular activities. The objective of this study was to compare the incidence of back pain in twelve year old males at the end of summer term with that over the latter part of the summer vacation.

Design: A questionnaire based study, pre- and post summer vacation in a local Welsh language School.

Method: A cohort of 56 male school children in year 7 (12yr old) was given a structure questionnaire before and after their summer vacation. The questionnaire was designed to obtain information about back pain and contributory factors, with particular reference to load carried (backpacks, carrying style, load and duration) and additional physical activities including extra-curricular (types, standard and duration).

Results: A significant decline in the incidence of adolescent back pain was found over the summer vacation: 55% (29/53) pre to 40% (16/40) during the vacation (p = 0.016). Back pain did not appear to be affected by the use of backpacks or activities that required sitting down, such as watching television or play computer games.

Conclusion: A decrease in back pain prevalence occurs over the summer vacation. However, extra-curricular pastimes with relative inactivity (computer games, TV) or backpack use do not appear to be significant factors.


N E Fowler E Healey

Stature change has been used to indicate the stress associated with specific tasks. Interpretation of stature change is often related to the diurnal change found in healthy participants. However, it has not been determined whether individuals with chronic Low Back Pain (LBP) experience a similar diurnal pattern. The aim of this study is to investigate diurnal stature change in individuals with and without CLBP.

Eight participants with LBP and eight matched asymptomatic controls took part in the investigation. Twenty-four stature measurements were made across a 24 hour period using a standing stadiometer. Differences between the two groups were analysed using two-way ANOVAs (time x group). Correlations between stature change and levels of low-back discomfort were examined using Spearman’s rho.

A clear diurnal variation was found for both groups, with the trough to peak variation in stature of 17.9 mm (LBP) and 17.6 mm (control) groups did not differ significantly (P > 0.05). Both groups experienced their greatest stature change in the 1st hour after rising 31.3% (LBP) and 44.6% (Control) of the total stature change. Towards the end of the day stature in the chronic LBP group reached a plateau while the control group continued to shrink. Between 2pm and 6pm both groups demonstrated a previously unreported recovery of stature. Reasons underlying this finding could be hormonal, behavioural or due to hydration status and require further investigation. A significant correlation was found between low-back discomfort and stature change in the LBP group, whereby when stature was lost greater discomfort was experienced and when stature recovery discomfort decreased.


D Carnes D Ashby M Underwood

Background: Pain is complex and multifaceted. We can convey information about pain by communicating verbally, textually and non-verbally. We investigated the use of pain drawings as an aide to communication and compared it with verbal and other pain measurement tools.

Method: We conducted a qualitative study using in-depth interviews with a purposive sample of pain patients. Data were analysed using the ‘Framework Approach’.

Results: Aches and pains are seen as an increasing continuum, aches distract people, pain stops them doing things. As pain progresses along the continuum patients pain reports progress from verbal through textual to visual representation. Verbal and textual communication about pain was inconsistent, especially for those with multi site pain. Visual communication was more about significant pain, verbal covered the range. As pain worsened so did the complexity, the need for help, life change and communication all increased. Current measuring tools do not seem adequate to assess multi site pain, transient pain and pain with movement.

Conclusions: Two methods of describing pain exist, clinical (physical symptoms) and behavioural (effect on life). Patients felt confident communicating about the latter but perceived a need for active help by the clinician for the former.

The effect of pain on lifestyle is paramount to the patient, physical symptoms for the clinician. Acknowledging this disparity may reduce frustration experienced in consultations as both have different communication and management needs. Indicating treatment success by focusing on lifestyle improvement in patients rather than reductions in physical symptoms may be more appropriate.


T Pincus NE Foster S Vogel AC Breen M Underwood

Background: Chiropractors, osteopaths and physiotherapists play key roles in the management of low back pain patients in the UK In our previous work we used mixed methods to investigate theor cognitions and attitudes to treating back pain. We developed and tested a scale, the Attitudes to Back Pain- Musculoskeletal Practitioners Scale, which includes both a personal and professional dimensional

Purpose: The purpose of this study was to investigate the differences between the attitudes of three professional groups: Chiropractors, Osteopaths and Physiotherapists.

Methods: A cross-sectional questionnaire survey was sent to 300 practitioners randomly selected from the registers of each profession. The returned questionnaires (N=465, response rate 61%), including the new ABS-mp and a questionnaire about personal and professional factors were analysed, using ANOVA, to compare the responses from the three groups.

Results: Physiotherapists tend to limit the number of treatment sessions offered to LBP patients. They work more clearly within a re-activation approach than their colleagues in the either of the other two professional groups. When practice setting (NHS versus private practice) was considered, the differences in personal interaction attitudes were unchanged but the differences in treatment orientation attitudes become less marked.

Conclusions: Aspects associated with practice settings, and especially those concerned with working within the NHS or privately impact on practitioners attitudes. There are also some professional differences, indicating that physiotherapists hold attitudes more closely in line with current guidelines.


D Carnes D Ashby S Parsons M Underwood

We conducted a community survey of the prevalence, health impact and location of chronic pain. We explored the relationship and patterns of chronic pain that commonly occur, with a view to understanding why some treatment approaches may be more appropriate than others for particular patterns of pain.

In 2002, 2504 randomly sampled patients from 16 General Practices in the South East of England responded to a postal questionnaire about chronic pain. Those with chronic pain completed a pain drawing. We calculated descriptive statistics, relative risk and correlations to identify the associations and risks of having linked pain.

The highest prevalences were low back (23%), shoulder (20%) and knee (18%) pain. The number of pain sites experienced was age related in men but less so in women. Lower body pain was more age related than upper body and non musculoskeletal pain. Multi site pain was more common than single site pain. Of those with low back, knee and shoulder pain, 14%, 4.5 % and 1.9% had only low back, knee and shoulder pain respectively. Correlations and minimum spanning trees showed that chronic upper and lower body pain are distinct and axial pain link the two.

Chronic pain is more likely to be multi site, especially at middle age. Research, physical treatments and approaches to managing chronic pain are often site specific, therefore specialising treatment to one area eg low back pain often negates the bigger issue. This may help explain the self perpetuating problem of persistent chronic pain.


Y. Schroeder D. McNally K. McKinlay W. Wilson J.M. Huyghe F.P.T. Baaijens

Introduction: In vivo measurements of intradiscal stresses are difficult. McNally measured stress profiles in human discs. It is unclear why some exhibit stress peaks in posterior annulus while others do not. Therefore finite element (FE) models are useful to improve the knowledge of stress distribution in the disc. We compared experimental and numerical stress in discs under axial loading, in non degenerated and degenerated disc.

Methods: The FE disc model resembles one fourth of a full disc. The annulus contains both matrix and fibers, while the nucleus only consists of matrix. Similar load profiles were applied and model predictions of matrix stress were compared to experiments (stress profilometry).

Results: Both experimental data and numerical simulations exhibit a peak of axial stress in posterior annulus and lower peaks in anterior annulus. Simulating a “normal” disc results in a uniform matrix stress profile from posterior to anterior. By reducing the fixed charged density (FCD) to 50% in both nucleus and annulus, stress profiles become non-uniform. Stresses in the nucleus decrease. Axial annulus stresses exhibit peaks on anterior and posterior side. Stress peaks increase when FCD decrease under the same loading.

Discussion: The size of the peaks computationally depends on the FCD in discs. Decreasing the FCD shows development of stress peaks in the annulus. A uniform stiffness is seen in nucleus region, but not in annulus. The hydrostatic pressure, due to the FCD, is not high enough to evenly distribute the load over the whole disc. The posterior stress peaks may explain why hernia develops particularly in the posterior annulus.


A S Przybyla S Blease M A Adams P Dolan

Introduction: Neck pain often arises without any evident trauma suggesting that everyday loading may cause fatigue damage to spinal tissues. However, little is known about the forces acting on the cervical spine in everyday life. The purpose of this study was to determine spinal compressive forces using an electromyo-graphic (EMG) technique.

Methods: Eight subjects performed a number of tasks while cervical flexion/extension and surface EMG activity of upper trapezius and sternocleidomastoid were measured. Dynamic EMG signals were corrected for contraction speed, using a correction factor obtained from lumbar muscles, and were then compared with isometric calibrations in order to predict moment generation. Calibrations were performed in different amounts of cervical flexion/extension by each subject to account for changes in the EMG-moment relationship with muscle length. Compressive force on the C7-T1 intervertebral disc was determined by dividing the generated moments by the resultant lever arm of flexor or extensor muscles obtained from MRI scans on the same subjects.

Results: Peak values (mean ± SD) of extensor and flexor moments increased from 1.9±1.6Nm and 1.4±1.0Nm respectively in standing to 52.7±32.2Nm and 4.2±1.8Nm when lifting above the head. Resultant muscle lever arms ranged between 3.0–5.2cm and 1.6–3.5cm for extensor and flexor muscles respectively. Therefore, peak compressive forces on the C7–T1 disc were 110±74N in standing and 1570±940N during overhead lifting.

Conclusion: Neck muscles generate high forces in activities such as overhead lifting. If applied on a repetitive basis, such forces could lead to the accumulation of fatigue damage in life.


IW McCall J Menage P Jones S Eisenstein T Videman A Kerr S Roberts

Background: Many studies have examined magnetic resonance images (MRI) with a view to the anatomy and signaling properties of the intervertebral disc and adjacent tissues in asymptomatic populations. In this study we have examined MRIs of a discrete population of patients undergoing surgery for symptomatic disc herniations.

Methods: Sixty patients (aged 23–66 years, mean 41.5±8.4) had sagittal T1 and T2- weighted turbo spin echo imaging of the lumbar spine prior to surgery. One disc was herniated at L2-3, 3 at L3-4, 22 at L4-5 and 31 at L5-S1; 3 patients had herniations at both L4-5 and L5-S1. The images were scored for disc narrowing and signal, degree of anterior and posterior bulging and herniation, and assessed for Modic I and II endplate changes and fatty degeneration within the vertebrae. These were carried out for each of 6 discs (T12-S1) for all patients (ie 360 discs and 720 endplates).

Results: There were trends of increasing disc narrowing, disc bulging and fatty degeneration with increasing age in these patients. 83% of patients had disc bulging, 53% had endplate irregularities and 44% had fatty degeneration. There was a significant correlation between patient weight and fatty degeneration. 7.5% of vertebrae (in 22% of patients) demonstrated Modic I changes whilst Modic II changes were seen in 14% of vertebrae (40% of patients). This is considerably higher than the incidence reported in asymptomatic individuals where Modic I changes were seen in 0.7% of vertebrae (3% of individuals) and Modic II changes in 1.9% of vertebrae (10% of individuals).

Conclusion: There is a higher incidence of Modic I and II changes in disc herniation patients than in asymptomatic individuals.


L Dang D Wardlaw D Hukins

Introduction: This abstract describes the development of an effective procedure for removing as much nucleus as possible from an intervertebral disc with minimal disruption to the annulus. The procedure was developed on cadaveric sheep discs which are well established as a model for human discs in studies of this kind. The purpose of the study was to develop a method for removing the nucleus as part of a laboratory study of nucleus replacement; however, it is also intended to guide the development of procedures for the removal of residual nucleus when indicated in surgical procedures that involve replacing the nucleus with synthetic materials.

Methods: All procedures were performed via a 3 mm trocar. Four procedures were compared: (I) unilateral approach using rongeurs alone, (II) bilateral approach using rongeurs alone, (III) unilateral approach using rongeurs followed by chymopapain and (IV) bilateral approach using rongeurs followed by chymopapain. Chymopapain was administered as a solution (30 units in 0.1 cm3 de-ionised water) to a disc at 37oC. For each procedure (I–IV) 14 discs were used.

Results: The percentages of nucleus removed were: (I) 34 ± 2%, (II) 41 ± 2%, (III) 52 ± 3% and (IV) 75 ± 8%; ANOVA showed a significant differences between the four sets of results (P < 0.05).

Conclusions: Significantly more nucleus is removed using a bilateral than a unilateral approach; significantly more nucleus is removed if chymopapain is used in addition to rongeurs.


M Hossain LDM Nokes

Background: Sacro-iliac (SI) joint is vertically oriented and subject to a large shear force on weight bearing. Gluteus maximus is strongly active when we experience an abrupt limb loading and need a stable SI joint. Suboptimal gluteus activity could disrupt weight transference and lead to low back pain as the body attempts compensation by recruiting biceps femoris, which could exert its influence through attachment to sacrotuberous ligament. A biomechanical model of SI joint dysfunction was proposed. The model was tested on a pilot study.

Methods: Two male volunteers participated in the study. One was a normal subject. The other had pain suggestive of SI origin. Electromyogram was recorded using pairs of disposable bipolar surface Ag/AgCl electrodes on the symptomatic side for the lumbar multifidus, gluteus maximus and biceps femoris muscles. Subjects were asked to walk in a straight line. Each test was taken three times for two full gait cycles. Two dimensional high speed video was used to capture data of walking motion. Raw electromyogram data was processed according to published protocols.

Results and discussion: Gluteus activation was poor in the symptomatic individual and failed to reach a peak in loading response. Biceps remained activated on terminal swing event with another peak activation in ipsilateral pre-swing event. Unlike normal volunteer, gluteus failed to show increased activity in terminal stance to pre swing events. The study showed a difference in gluteus maximus and biceps femoris activity in between the two volunteers. A larger study is planned to validate the model.


T Grünhagen C P Winlove J P Urban

Background and Purpose: During normal loading of the spine, the intervertebral disc (IVD) experiences large changes in hydration. Current techniques to determine IVD hydration in vitro non-destructively are costly (e.g. MRI). Here we determined the variation in hydration in loaded IVDs electrochemically using needle microelectrodes.

Methods: The relation between hydration and electrochemical current measured in the tissue at a polarising voltage of −0.65V was established in bovine caudal disc nucleus slices. Bovine caudal IVDs were then placed in a culture chamber and tissue hydration varied by applying static loads. Silver needle microelectrodes were inserted into the nucleus at defined locations and the polarising voltage applied. The electrochemical current was measured and hence hydration of the disc determined in relation to duration and magnitude of the applied load.

Results: Intradiscal current was found to correlate directly with tissue hydration, falling 45% as hydration decreased from 0.8 to 0.6. Changes in tissue hydration in response to static load were monitored at different positions in the disc in real-time by measuring electrochemical current and were found to vary spatially and in time as predicted from theory.

Conclusions: Electrochemical measurements can be used as a non-destructive and relatively inexpensive method for real-time measurements of changes in IVD hydration in response to mechanical loading in vitro.


M Bhattacharyya

Introduction: Primary manifestation of Non Hodgkin’s lymphoma in the urinary tract has been sporadically reported [1,2,3,4,5]. 2.7% of extra nodal Non Hodgkin Lymphoma manifest in urinary tract and commonly disseminate in the vertebrae. We report an unusual presentation of primary B cell lymphoma, presenting as upper back pain and acute retention of urine in a female. To our knowledge it has never been repoted in the literature.

Material: Illustrative Case report of a 63 years non smoker retired old female presented to us with a history of acute urinary retention and back pain.

Discussion: Upper back pain and urinary retention in a female is very uncommon presentation. It may be associated with sinister pathology. In our case study extra nodal manifestation of B cell lymphoma in the female urethra with dissemination and its rare clinical presentation is unique early diagnosis and multidisciplinary involvement is essential.


S D Liddle G D Baxter J H Gracey R A Deyo

Focus group methodology was used to explore the experiences, beliefs and treatment expectations of chronic low back pain (LBP) patients in order to identify what components of treatment they considered to be of most value: specific emphasis was placed on the importance of advice and exercise to these patients.

Methods: Using a purposive sampling procedure, three focus groups were convened. All participants (n=18) were currently experiencing chronic LBP (> 3months), with no red flags, and had received advice and exercise as part of treatment. Each group was facilitated by an independent moderator, and guided by a series of pre-determined questions, although participants were encouraged to freely air their personal opinions. Discussions were tape-recorded and transcribed, with the written consent of all participants. Transcribed data were categorised into a series of ‘nodes’ from which a series of common themes emerged.

Results: A variety of occupations and age groups were represented; one group consisted solely of females, and the other two were of mixed gender. The appropriateness of treatment was largely weighted upon the provision of a precise diagnosis. Participants acknowledged the value of advice and exercise provided by practitioners, however their lack of compliance with such programmes was a key factor limiting their long-term self-management of symptoms.

Conclusions: Clinical practice must incorporate strategies to improve compliance with advice and exercise. Individually tailored treatment programmes with follow-up support and direction, along with a better understanding of the physical and emotional impact of chronic LBP by practitioners, is recommended by patients.


CJ McCarthy JA Oldham

Introduction: A large number of patients with non-specific low back pain (NSLBP) are examined by physiotherapists. Physiotherapists ask their patient’s questions, as part of their clinical examination, however the reliability of the information elicited by these questions has never been examined.

Methods: Following a Focus group with a sample of physiotherapists (n=30), and subsequent Delphi technique questionnaire, a list of questions and tests for the clinical examination to NSLBP was developed. The clinical examination list was then tested for item inter-tester reliability with 100 NSLBP patients and 16 physiotherapists. Patients were assessed by both physiotherapists on one day. Data were analysed using kappa coefficients for nominal data and weighted kappas for ordinal data.

Results: The physiotherapists rated issues regarding the location and quality of pain with good levels of reliability, kappa values ranged from 0.49 to 0.64. Diurnal changes in pain and history of pain were also reliably ascertained (Kappa values ranging from 0.49 to 0.73), with symptoms other than pain demonstrating good reliability (values ranging from 0.50 to 0.77). Issues regarding the affect of psychosocial issues as barriers to recovery and the degree to which the patient’s pain was affecting their function were not as reliable (kappa values from 0.14 to 0.51)

Conclusions: It is clear that whilst the questions typically used in the clinical examination of NSLBP are reliable when addressing simple issues relating to the report of symptoms, more complex issues are less reliable and further work is required to improve the reliability of the information obtained.


D W Neen N C Birch

Statement of purposes of the study and background: Validated outcome measures should be an essential tool in clinical practice. The Oswestry Disability Index (ODI), since its publication in 1980, is now a principle measure of condition-specific outcome in spinal management. The Low Back Outcome Score (LBOS), another popular measure, emphasises objective questions and gives a broad based status for low back illness. We have analysed the use of these instruments to see if they were directly comparable.

Method: Fifty five consecutive patients attending our clinic between February and June 2005 for treatment of low back disorders completed the questionnaires. These were then scored in the conventional manner. To directly compare LBOS with ODI the LBOS score was converted to a percentage and inversed. The individual LBOS evaluations were then marked in two ways. Firstly the questions that did not appear to correlate to the ODI were removed. Secondly the weighting system was adjusted to match the ODI weighting. Statistical regression analysis was performed.

Results: Direct comparison of ODI versus an inverse of the LBOS percentage score gave a scatter of results. The R squared result was 0.117

Removing the non-core answers from the LBOS gave an R squared value of 0.130

Removing the weighting of the LBOS gave an R squared value of 0.132

Removing the non-core questions and weighting system of the LBOS gave an R squared value of 0.133

Conclusion: These two validated disease specific outcome tools provide very different results when applied to the same group of patients. This has significant implications for outcome research especially when comparing studies which do not use similar instruments.


D K Gakhal E M Reynolds R C Chakraverty P B Pynsent

Purpose And Background: In patients with chronic low back pain (LBP), selective injection procedures (provocative discography, medial branch, facet and sacroiliac joint blocks) have shown the pain source to be the intervertebral disc in 40%, the sacroiliac joint in 13–19% and the facet joints in 15–40%. No individual features in the history or examination are of consistent discriminatory value in diagnosis.

This study aimed to assess whether patients with different pain sources could be differentiated using the Oswestry Disability Index (ODI) (a validated patient questionnaire scoring ten different aspects of pain and function in patients with LBP; higher scores correlating with greater disability).

Methods And Results: ODI scores were recorded from 67 patients (46 female, age 17–82) whose source of LBP was subsequently confirmed by selective injection. The scores for each section of the ODI were compared between patients grouped according to pain origin; disc (n=11), sacroiliac (n=31) or facet (n=25).

Patients with disc pain had significantly greater overall disability and scored higher for sitting, sleeping and social activity than those with facet or sacroiliac pain as judged by the 95% confidence limits of the median (p< 0.05). Patients with facet pain scored higher for walking and standing compared to those with sacroiliac pain.

For disc pain scores were higher for sitting and standing than for walking, and for facet pain scores were higher for standing than for sitting or walking.

Conclusion: Although the ODI is not a diagnostic tool, analysis of its components reveals characteristic pain and disability patterns in patients sub-grouped according to pain source.


LJ Potter C McCarthy J Oldham

Introduction: Algometry has been shown to be an effective way of quantifying pressure pain threshold (PPT), although it’s reliability in assessing spinal muscle pain (excluding trigger points) has not been robustly analysed.

Method: Intra-rater test re-test reliability PPT assessment by algometry over the belly of four pairs of spinal muscles, (iliocostalis, multifidus, gluteus maximus and trapezius) in a healthy sample (80 assessments) was analysed. Healthy subjects were tested twice (within 15mins) on three occasions (separated by a week); 240 sets of assessments revealed good within-session reliability (ICC> .91) and good between session reliability (ICC> .87), with a relatively small measurement error (approximately 3kg/cm2) and no systematic difference within session or between sessions.

Conclusion: In conclusion, PPT assessment by algometry is a reliable, both within and between sessions, measure of a subject’s pain. This study provides further validity to the use of this measure as a suitable, convenient method of monitoring treatment effects.


M Bhattacharyya

Introduction: The potential medical applications of cannabis in the treatment of painful muscle spasms and other symptoms of multiple sclerosis are currently being tested in clinical trials. The active compound in herbal cannabis, Delta(9)-tetrahydrocannabinol, exerts all of its known central effects through the CB(1) cannabinoid receptor. Research on cannabinoid mechanisms and antinociceptive actions is evolving.

The aim is to study whether cannabis has any role as a pain relief agent in chronic degenerated disc disease without spinal stenosis.

Method: Prospective audit observational study

Material: During two years periods 17 afrocarribean male patients who are regular cannabis user and MRI confirmed disc disease participated in this survey who had opiates and epidural injection therapy.

Result: All had used cannabis such as marihuana, hashish as a recreational drug before the onset of their illness. 64.7% of the patients stated the symptoms of their illness to have ‘much improved’ after cannabis ingestion, 29.4% stated to have ‘slightly improved’. 76.4% stated to be ‘very satisfied’ with their therapeutic use of cannabis.

Conclusion: This survey reveals use of cannabis products for symptomatic relief of back pain. However it is limited by highly selected patient group, no conclusions can be drawn about the quantity of wanted and unwanted effects of the medicinal use of the plant for particular indications. Physician supervision of medical marijuana use would allow more effective monitoring of therapeutic and unwanted effects. Medicines based on drugs that enhance the function of endocannabinoids may offer novel therapeutic approaches in the future.


M Bhattacharyya H Win S Sakka

Introduction: Spinal stenosis may present as intermittent claudication and may be indistinguishable from vascular claudication as both could co exist. These patients often required expertise from both the speciality. Combined Vascular and spinal clinic after primary screening with the help of MRI scan may reduce the waiting time to the appropriate speciality.

Aim: We prospectively reviewed all the patients referred to senior author from vascular unit to assess the final outcome and evaluate whether primary to referral to vascular surgeon was unnecessary.

Study Design: Prospective study from November 2004 to May 2005

Methodology: Review of Hospital case notes – 23 patients were referred to us from one of the vascular surgeons’ unit after excluding vascular etiology as the cause of the leg pain and MRI confirmation of spinal stenosis.

Result: Mean waiting time to see the spine consultant 103 days [20–195] from the date of referral by the vascular team. The waiting time to primary referral to vascular team was 164 days [43–194]. 43.5% of the referred patients required to have spinal decompression.

Conclusion: To improve the waiting time primary physician should have access of MRI scan to delineate the pathology and combined vascular and spinal clinic may achieve waiting time target.


B.K. Derham J Urban

Purpose: To investigate the effect of timed incubations and osmolarity on the cellular protein profile between nucleus pulpous cells and articular chondrocytes to identify possible cellular markers. Both cell types exists in a constantly interchanging environment in which osmolality changes significantly during disc and joint loading.

Methods: Bovine nucleus pulpous and articular chondrocyte cells were isolated and digested with collagenase. The cells were resuspended in alginate beads and incubated in DME medium. DMEM was prepared with increasing osmolarity (280–580mOsm). At T=0,1,3 & 5 cells were collected by dissolving the alginate beads and then washed. Cellular proteins were analysed by large SDS-PAGE, scanned and analysed by computer package. Bands of proteins of interest were cut out for mass spec analyses.

Results: Analysis of whole cells from the nucleus pulpous and articular chondrocytes by SDS-PAGE at T=0 revealed very similar protein patterns. Over 5 days a peak at around 26kDa that appeared in both cell groups. Differences occurred when the cells were incubated with increasing osmolarity. Nucleus pulpous cells showed a loss of peak intensity around 60kDa and 32kDa. Chondrocyte cells showed increased peak intensity around 140kDa, as well two peaks flanking a major peak at around 55kDa.

Conclusion: Incubation of both cell types in alginate beads caused the appearance of a new peak on SDS-PAGE. When both cell types were incubated with increasing osmolarity new protein peaks appeared which may assist in deciphering between the two cell types. Mass spec will identify the protein peaks.


W W Yoon G Askin P Cole C Natali

Introduction: This study highlights the occurrence of significant post operative scoliosis associated with en-bloc resection of pancoast or superior sulcus tumours. We observed the rapid onset of high thoracic scoliosis following en-bloc resections. The Magnitude of the scoliosis, and predisposing surgical factors were reviewed in each of the cases implicating the role of the transverse process or its associated structures in the stabilization of the spine.

Methods: Sixteen patients undergoing en-bloc resection for pancoast tumour were retrospectively reviewed. This was a single surgeon series where all patients had tumour resection over a 3 year period. The number of upper ribs and transverse processes resected were analysed and compared with the magnitude of scoliosis that developed over a follow up period of 2 years.

Results: Four patients had significant resection of the transverse processes of T1 to T3. All of these patients developed scoliosis of rapid onset, convex to the side of the resection. Of the remaining 12 patients either no scoliosis developed, (6 of 12), or scoliosis of less than 12 degrees.

Discussion: We observed rapid development of thoracogenic scoliosis in patients following lung tumour and chest wall resection. Our study shows that excision of the transverse processes is associated with subsequent development of an upper thoracic scoliosis. Preservation of the transverse process appears to be protective. Large resections can be performed with no subsequent scoliosis provided the transverse processes remain intact.

This suggests that the transverse process or its associated structures have an important stabilizing function on the spine.


W W Yoon W Ryan C Natali

Introduction: Postoperative overdistention of the bladder produces chronic, irreversible changes in the detrusor muscle. This study investigated whether an effective epidural, may cause postoperative overdistention of the bladder.

Methods: A retrospective single surgeon/unit study of 144 male patients who had undergone spinal surgery over a two year period was undertaken. Data was collected into two groups: Patients requiring catheterisation and those that did not. All patients received a 16G epidural catheter inserted at the end of the procedure.

Demographics, operation type and epidural rate were all correlated with the need for catheterization. In all cases the residual volumes were recorded.

Results: Patients remained on postoperative epidural analgesia for an average of 50hours. 54 patients required urinary catheterisation. The average postoperative duration until catheterisation was 18hours, with a maximum of 33hours.

The average residual volume at catheterization was 936mls, with a maximum of 2200mls. All patients were managed with intermittent catheterisation, most, (63%) requiring only a single episode before spontaneously voiding.

Discussion: Although patients in the catheterised group were older, (p< 0.05), we found no other significant differences in patients that subsequently required catheterisation, when compared for operation type, or epidural infusion rates.

We were therefore unable to predict which patients would require catheterisation. Questioning and bladder palpation was found to be unreliable when assessing overdistention.

Our study demonstrated that patients undergoing spinal surgery using epidural analgesia should be closely monitored in order to prevent overdistention of the bladder and has led to a proactive regimen for spinal patients with epidural analgesia in our unit.


Jm Huyghe S Wognum Y Schroeder W Wilson Fpt Baai Jens

Degeneration of the intervertebral disc results in patent cracks [1] and a decrease in osmotic pressure associated with loss of fixed charges. The relationship between mechanical load and damage in the disc is very poor [2]. This finding is at odds with physical intuition. The subject of this study is relationship between the development of patent cracks and the decrease in osmotic pressure in the degenerating disc in the light of the physics of swelling [3–7]. We restrict the experimental part of this study to hydrogel, thus avoiding complications associated with biological variability. The finite element modelling [6,7] used in this study catches salient features of stress profiles measured by Mc Nally and al.

Thin hydrogel samples with a crack of 5 mm are used. The crack opens as a result of decreasing osmotic pressure in the experiments and in the simulation. The initial uniform stress distribution turns into a distribution with a decreased average stress level and a high stress around the crack tip. A decrease in osmotic pressure opens an existing crack in swelling materials independently from external mechanical load. Hence, disc degeneration causes the overall stress to decrease, while local stress around a crack tip increases. This mechanism may explain why damage in the disc is so poorly correlated with mechanical load [3] and why the degenerated disc is characterized by patent cracks [1]. The process of crack opening in the degenerating disc is comparable to the crack development in an aging oaken beam, while loosing its turgor.


M Bhattacharyya S. Mcneil S Sakka

Aim: We present a pilot study on the conservative treatment of chronic low back pain (LBP) using an orthosis. It consists of a pneumatic custom made lumbar vest (Orthotrac), which permits both support-stabilisation and decompression. This system allows patients to perform any activity while wearing it.

Material: The study included 9 patients with radicular pain due to degenerative discopathy including: dark disc, discal protrusion with neural foramina involvement, stenosis of the foramina. Patients had to wear the Orthotrac vest according to a precise protocol, 60 minutes 3 times a day for 5 weeks.

Results: 5 patients (55.5%) have showed a significant subjective and clinical improvement with subsequent better quality of life. All patients referred a decrease or disappearance of radicular pain. Outcome measures were evaluated VAS pain scale and SF-36 follow up questionnaires. Two (22.2%) patients reported to have no benefit.

Conclusion: The pneumatic vest can play an important role in non-surgical therapy for low back pain. The system seems to give an effective spinal decompression and deserves a careful consideration when lumbar discal disease is treated non operatively.


J Luo D Skrzypiec P Pollintine P Dolan

Introduction: To evaluate whether a biologically-active cement “Cortoss” confers any short-term mechanical advantages when compared with a polymethylmethacrylate bone cement “Spineplex” which is currently in widespread use.

Methods: Two thoracolumbar motion segments were harvested from each of six spines (51 – 82 yrs). Specimens were compressed to failure in moderate flexion to induce vertebral fracture. Pairs of specimens were randomly assigned to undergo vertebroplasty with either Cortoss or Spineplex. Compressive stiffness and compressive stress on the disc were measured before and after fracture, and after vertebroplasty. Compressive stress was measured by pulling a pressure- sensitive needle through the mid-sagittal diameter of the disc whilst under 1.5kN load. Intradiscal pressure (IDP), peak stress in the annulus and neural arch compressive load were obtained from the resulting stress profiles.

Results: No differences in IDP, annulus stress, neural arch load bearing and compressive stiffness were observed between the groups before fracture, after fracture or after vertebroplasty (p> 0.05). After fracture, IDP decreased from 1.02 to 0.68 MPa in flexion and from 0.75 to 0.34 MPa in extension (p< 0.05), neural arch load bearing increased from 13% to 37% of the applied load in flexion (p< 0.05), and compressive stiffness decreased from 2441 to 1478 N/mm (p< 0.05). After vertebroplasty, these changes were largely reversed: IDP increased to 0.45 MPa in extension (p< 0.05), neural arch load bearing fell to 20% in flexion (p=0.1), and compressive stiffness increased to 1799 N/mm (p< 0.05).

Conclusion: Vertebroplasty using either Cortoss or Spineplex was equally effective in reversing fracture-induced changes in motion segment mechanics.


M Ismail P Rosenfeld

Isolated arthrodesis of the subtalar joint has the advantage that it preserves some motion at the midfoot. In cadaveric studies, movement at the Talonavicular joint is reduced by up to 74% and at the Calcaneocuboid joint by up to 44%. This allows some midfoot flexibility, which would not occur with a triple arthrodesis.

There are several methods of performing a subtalar arthrodesis, broadly divided into extra or intra articular techniques, using structural or cancellous bone graft and a variety of fixation methods.

Earlier studies on primary arthrodesis have shown rate of non union from 0 – 6%. More recently, larger studies have reported higher rates of non union from 14 – 17%.

We present the results of 95 subtalar fusions performed with a standard technique, using one screw from the calcaneum to the talar dome, with 100% follow up.

Between 1993 and 2003 the senior author performed 105 subtalar arthrodeses. We performed a retrospective chart review. All patients with a primary subtalar fusion were included. All cases had been refractory to conservative therapy.

The senior author reviewed all patients until fusion had occurred or a diagnosis of nonunion was established. Fusion was diagnosed when the patient were pain free while fully weight bearing, with a clinically rigid subtalar joint and radiographs showing trabeculae crossing the arthrodesis. A CT scan was performed in all cases where nonunion was suspected, and the patient complained of persistent pain.

A total of ninety five subtalar arthrodeses were performed in ninety two patients. All were reviewed with clinical and radiological examination, until union had occurred or nonunion diagnosed. The average time to union was 5.0 months, range 3 – 12 months. The outcomes, graded using the method of Angus and Cowell, were 21 Fair, 7 Poor and 67 Good results


I Winson P Laing N Makawana S Hepple W Harries

Introduction: Osteochondral lesions of the Talar Dome(OCD) remain a difficult therapeutic problem. One solution has been to consider using autologous chondrocyte implants. Though initial results of this technique are interesting the donor sites have always been in a normal knee. The presence of knee symptoms subsequently in some patients might be regarded as inevitable. This paper reports on the viabilty of donor material taken from the ankle.

Materials: Twenty four patients have been recruited to a pilot study of the viability of obtaining donated chondral material for Matrix Autologous Condrocyte Implantation. There were 14 men and 10 women. Their mean age was 37.3 years (range 17–63). All were complaining of presistent symptoms of pain and some insecurity following previous conventional surgery for treatment of a symptomatic OCD. All had MRI evidence of ongoing changes in keeping with persistent problems related to an OCD.

Methods: All patients had an initial arthroscopy of the affected ankle to reassess the state of the joint surface. Donor articular cartilage was obtained from one of three sites. The anterior part of the joint surface on the talar neck, from the medial articular facet of the talus or rarely from an area of articular cartilage on the edge of the lesion. The mean weight of the donor harvest was 133 micrograms(range51–450).

Results: All donated graft material produced viable implantable graft material between 5 and 7 weeks from harvest. Cell counts ranged from 12.3 million to 20 million with cell viabilities of 98% or above. These figures are directly comparable with the results obtained from the knee despite the original donor weights being less.

Conclusion: If this technique is contemplated the use of the affected ankle as a donor site is a viable alternative to the knee.


R Ramiah S Hepple I Winson

Aim: A medium term review of total ankle replacements with a view to reviewing follow up protocols, reassessing the usefulness of the SF12 Health Survey questionnaire, and to determine factors that may indicate early failure.

Method: Sixty-five ankle replacements in 58 patients with an average age at operation of 65 (44–80) (32 males: 23 females, 3 died) were reviewed after a mean of 41 months (8–97 months). They were assessed via postal questionnaire and a research clinic with regard to their pain, difficulty and SF 12 scores, their outcome perception and range of movement. Additionally, we looked retrospectively at their notes and latest X-rays.

Results: Indications for operation were OA (79.5%), RA (18.2%) and psoriatic arthropathy (2.3%). Patients’ perceptions of their outcomes were 41(78.8%) good, 5(9.6%) moderate and 6(11.5%) poor. The average “mean pain score” was 3.6 and average “mean difficulty score “ was 4.0. There was no significant change between the pre and post-operative mean SF 12 scores. Save for 2 anomalies, poor outcomes and SF12 scores were only seen in post-traumatic OA(100%) and RA patients. Prostheses used were Beuchel-Pappas, OSG and DePuy Mobility. There are no revisions to date. The average range of movement was 26°. X-rays generally showed good prosthesis alignment, minimal insert wear, occasional non-enlarging, small (1–2mm) cysts around the tibial component.

Conclusions: The SF 12 scores seem to be unresponsive. The pain and difficulty scores more reflect the patients’ perception of outcome. With the low incidence of revision, risk factors for early failure are difficult to establish but patients with radiological cysts, talar collapse or more severe deformities of the foot/ankle might be the ones who need regular review.


N Gougoulias S Parsons

Purpose: Methods: Evaluation of the results of arthroscopic ankle arthrodesis, performed in 49 consecutive patients (52 ankles), with disabling ankle arthritis, between 08/1998 and 12/2004. Thirty ankles had no significant deformity (group A), whereas 22 ankles had a varus or valgus deformity greater than 10° (mean 21.7°, max 45°) (group B). Mean age in groups A and B was 49.7 and 57.5 years respectively (p=0.15). The primary diagnosis in groups A and B was post-traumatic arthritis in 66% and 27% and idiopathic osteoarthritis in 17% and 59%, respectively. Average hospital stay was 3.63 and 3.68 days in groups A and B respectively (p=0.96). Postoperative treatment included ankle immobilization for 3 months. Progressive weight-bearing was initiated at two weeks. Mean follow-up was 14.9 months (range 6–60).

Results: No infections or neurovascular problems occurred. Fusion occurred in 29/30 cases in group A at an average time of 11.52±5.2 weeks and in 21/22 patients at 11.67±2.3 weeks in group B (p=0.89). Not planned surgical procedures were required in eight cases (15.4%). Symptomatic arthritis from the adjacent joints developed in three cases during the follow-up period. The arthrodesis position angle measured in the sagittal plane from the lateral post-operative plane film averaged 105°±3° and 103°±6° in groups A and B respectively (p=0.27). The outcome in groups A and B was graded as very good in 73% and 72.7%, fair in 23% and 22.7% and poor in one case in each group, respectively (p=0.26).

Conclusions: The arthroscopic technique offers a high fusion rate, decreased time to fusion, short hospital stay and absence of limb-threatening complications. Deformity correction can be attempted with equally good results.


R Smith P LR Wood

We aim to assess the outcome of ankle arthrodesis performed for painful osteoarthritis in the presence of a coronal plane deformity of 20 degrees or more. To our knowledge this is the first reported series of such a cohort of patients. We have a consecutive and complete series of 24 patients with 26 ankle arthrodeses which were all performed for painful osteoarthritis in the presence of large coronal plane deformity. These patients have a minimum of twelve months clinical follow up. The results showed a low non union rate of 8% (2 ankles). These have subsequently been refused satisfactorily, and were excluded from further analysis. The results of the remaining 24 ankles which united primarily show that they were very pleased with the outcome of their surgery. AOFAS scores were used to measure pain and function both pre operatively and post operatively. These scores showed large improvements for both pain and function, and had a high statistical significance (p< 0.0005). All patients improved in their walking distance and many patients reduced their need for walking aids. Stair climbing ability was also improved in some patients. It is recognised that an ankle arthrodesis usually relieves pain but does not result in a normal gait and full function. We feel that the high level of patient satisfaction in this series was due to the combination of deformity correction, restoring a functional foot position, and achieving a painless ankle. Arthroplasty of the ankle is a good procedure for relief of pain and restoration of function. However In the presence of a large coronal plane deformity ankle arthroplasty is known to fare badly with early failure. Therefore for patients with painful osteoarthritis and a coronal plane deformity of 20 degrees or more, we recommend ankle arthrodesis as the procedure of choice.


M Changulani N Garg A Bass Nayagam C Bruce

Aim: To evaluate our initial experience using the Ponseti method for the treatment of clubfoot.

Materials and Methods: 85 feet in 56 patients treated at Alder Hey Hospital, Liverpool between Nov 2002 – Dec 2004 were included in the study.

The standard protocol described by Ponseti was used for treatment.

Mean period of follow up was 12 months (6– 30 months).

Evaluation was by the Pirani club foot score.

Results: Results were evaluated in terms of the number of casts applied, the need for tenotomy and the recurrence of deformity.

Average number of casts required were 6.

Tenotomy was required in 80% of feet.

At the latest follow up approximately 15% of feet recurred following treatment and were managed surgically. Poor compliance was noted to be the main cause of failure in these patients. We have recently modified our splint and hope this will address some of the reasons for poor compliance. There was also a smaller subgroup of patients (approximately 5%) which failed to respond to the treatment regime and could not be brought to the point were tenotomy would be appropriate.

Conclusion: In our hands the ponseti technique has proved to be a very effective treatment method for the management of CTEV but like all treatment methods does have some limitations.


A Malviya B Ashton J Kuiper N Makwana P Laing

Aim: Concerns have been expressed that DMARDS may interfere with bone healing. Previous studies give conflicting advise and no consensus exist in current practise especially with the newer DMARDS such as Leflunomide, Etanercept, and Infliximab. The aim of this study was to assess the in-vitro effect of DMARDS and cox-2 inhibitors on Osteoblast activity.

Method: Osteoblasts were cultured from femoral heads obtained from five young otherwise healthy patients undergoing total hip replacement The cells were cultured using techniques that have been previously described. A computer aided design of experiment was used as a model for setting up the experiment on samples obtained from the five patients. Normal therapeutic concentration of the various DMARDS was added alone and in combination to the media. The cell growth was estimated after two weeks using spectrophotometric technique using Roche Cell proliferation Kit. Multiple regression analysis was used to estimate the best predictor of the final result.

Results: The most significant factor (p< 0.001) in predicting the ultimate response was the patient themselves. Cox-2 inhibitor (Etoricoxib) was found to have the most consistent effect although always in combination with some other drug which varied amogst different patients. Etoricoxib in fact had a stimulatory effect (R=0.219) on the osteoblast growth.

Conclusion: Different patients respond differently to the drugs. None of the DMARDS tested inhibit osteoblast proliferation and differentiation in-vitro. If osteoblastic activity is considered to be the primary factor responsible for bone healing, then an inhibition should not result in patients who are on these drugs.


M Costa K Logan D Heylings K Tucker S Donell

Introduction: Tendon lengthening is an important cause of morbidity after Achilles tendon rupture. However, direct measurement of the tendon length is difficult. Ankle dorsiflexion has therefore been used as a surrogate measure, on the assumption that it is the Achilles tendon that limits this movement. The aim of this investigation was to assess the relationship between Achilles tendon length and ankle dorsiflexion. The primary research question was whether or not the Achilles tendon is the structure that limits ankle dorsiflexion. The secondary purpose was to quantify the relationship between Achilles tendon lengthening and dorsiflexion at the ankle joint.

Methods: Five cadaveric specimens were dissected to expose the tendons and capsular tissue of the leg and hindfoot. Fixed bony reference points were used as markers for the measurements. In the first specimen, the Achilles tendon was intact and the other structures that may limit ankle dorsiflexion were sequentially divided. In the other specimens the Achilles tendon was lengthened by 1cm intervals and the effect upon ankle dorsiflexion movement was recorded.

Results: Division of the other tendons and the capsular tissue around the ankle joint did not affect the range of ankle dorsiflexion. When the Achilles was divided the foot could be dorsiflexed until the talar neck impinged upon the anterior aspect of the distal tibia. There was a mean increase of 12 degrees of dorsiflexion for each centimetre increase in tendon length.

Conclusion: The Achilles tendon is the anatomical structure that limits ankle dorsiflexion, even when the tendon is lengthened. There was a linear relationship between the length of the Achilles tendon and the range of ankle dorsiflexion in this cadaveric model. Ankle dorsiflexion would appear to be a clinically useful indicator of tendon length.


S Palmer R Venn J Coates S Umarjii F Middleton

Purpose: The aim was to determine whether intra-articular bupivacaine provides effective analgesia following ankle arthroscopy and whether it reduces the need for supplemental analgesia.

Methods: A power calculation revealed that 40 patients were required to provide a 5% significant level using a visual analogue scale. 40 patients were therefore randomised to receiving 20 mls of either bupivacaine or saline (control) after routine anterior ankle arthroscopic surgery. The tourniquet was released 10 minutes later. In recovery, supplementary analgesia of 2 tablets of co-codomol 30/500 orally or 50–100mg tramadol IV was available on request. A 10 day supply of 50mg diclofenac (8 hourly) and co-codomol 30/500 2 tablets (6 hourly) was provided.

A visual analogue scale (VAS) was employed as a direct indicator of pain and indirectly, supplemental analgesic requirement. Measurements were made pre-operatively and postoperatively.

Age, weight and tourniquet times were compared with Mann Whitney U test and Chi-square. Pain scores and analgesic requirements were compared using ANOVA at a 5% significance level.

Results: Pain scores were lower in the bupivacaine group compared to the control as was the need for supplemental analgesia.

Significance: We conclude that postoperative intraarticular bupivacaine provides effective analgesia following ankle arthroscopy.


H Kurup G Taylor

Arthrodesis of the ankle joint gives satisfactory short and medium-term results; however, in the longer term, it frequently leads to sub-talar and mid-tarsal osteoarthritis which is difficult to treat. Use of mobile bearings have significantly improved the results of ankle replacement. This a mid term follow up (1 to 5 years)of Buechel-Pappas ankle replacements performed by the senior author.34 total ankle replacements performed by one surgeon from October 1999 to May 2004 were reviewed retrospectively. Pre and post operative VAS scores, AOFAS scores were evaluated to find patient satisfaction and outcome. Tourniquet time as recorded in operation notes showed the learning curve for the procedure. Males : Females- 1:1.4. Mean age was 65 years (range : 33 to 83). Indication for surgery was primary osteoarthritis in 13, post traumatic arthritis in 14 and rheumatoid arthritis in 8. Average VAS score was 8.2 pre operative and improved to 2.0 at follow-up. AOFAS score improved from 39.1 to 72. Operating time averaged 113 minutes in 1999 and 85 in 2004. Significant complications were medial impingement (8) out of which 3 patients needed further surgery, intra-operative malleolar fractures (medial 4, lateral 1 and posterior 1, all healed successfully) and injury to cutaneous nerves (4) 3 patients had superficial infection which settled with antibiotics, but there were no cases of deep infection. 58 % were very happy, 32.5 % were happy, 9.5 % were not happy with the result. 2 patients had ankle fusion on the opposite side earlier, both were happier with the replaced side. Ankle replacements appear to offer a good alternative to fusion in selected patients. There is a significant risk of minor complications. Medial impingement may need further debridement at a later stage.


H Prem P Wood

Purpose: We evaluated the role of the Distal Tibial Line (DTL by Saltzman et al, 2005) in measuring the pre-operative and postoperative position of the talus on ‘lateral’ radiographs following a Total Ankle Replacement (TAR). Currently there is no validated measure of anteroposterior (AP) alignment of a TAR.

Arthritis in the ankle causes considerable malalignment in the anteroposterior plane. The DTL is not affected by the destruction of the tibiotalar joint and is independent of slight variations in the positioning of the foot and radiological magnification.

Method: DTL divides the talus into two sections and the proportionate length of the posterior segment is presented as a ratio. The size of the posterior segment and ratio decreases with anterior subluxation.

Radiographs of 200 cases of TAR were reviewed. The anterior and posterior outlines of the talus could not be seen in all cases (e.g. preoperative talonavicular fusion). As a result 49 cases of inflammatory arthritis (49 of 119) and 6 of osteoarthritis (6 of 81) could not be assessed.

Results: The osteoarthritic ankle (OA) in particular showed a tendency for anterior subluxation. The average ratio in OA cases increased from ‘34.8′ before surgery to ‘40.4’ after surgery, confirming a trend for this subluxation to reduce with a TAR.

There was a lesser tendency for subluxation in the inflammatory group of patients although the body of the talus itself was more deformed. The average preoperative value was ‘36.1’ and the post operative value was ‘38.9’.

Conclusion: We found the Distal Tibial line to be a reproducible parameter for measurement of AP alignment in TAR in the vast majority of OA cases. The change of anteroposterior alignment post surgery appears to be due to the restoration of soft tissue balance.


N Cullen A Robinson N Chayya J Kes

Introduction: The Distal metatarsal articular angle (DMAA) is a radiographic measure of orientation of the first metatarsal articular surface, it is frequently used in the management of hallux valgus. There is a great deal of conflict regarding accuracy, reproducibility and validity of the DMAA within the literature. This study aims to test the validity of the measurement of the DMAA from standard radiographs, to explore the trigonometric relationship of first metatarsal rotation and the DMAA and to assess inter-observer reliability.

Materials/Methods: 34 seperate dry cadaveric first metatarsal bones were mounted onto a customized light-box/protractor allowing controlled incremental changes in rotation and inclination. A series of 39 digital photographs were taken of each metatarsal in 5 degree increments of rotation between 30 degrees supination and 30 degrees pronation and 10, 20 and 30 degrees of inclination. Three reviewers performed blinded DMAA measurements from each image; the data was collated for statistical analysis.

Results: The data was analysed using a mixed effects linear model comparing the DMAA with rotation of the first metatarsal. A strong statistically significant trend of increasing score with increasing pronation is observed, the relationship of which is approximately linear. There is a strong effect of inclination, but the strength of this varies with rotation this is amplified at higher inclinations. Inter-observor error was noted in line with other studies, the linear relationship is maintained.

Discussion: This study has shown that the distal metatarsal articular angle varies significantly, in an almost linear pattern, with axial rotation of the first metatarsal. Inclination of the first metatarsal is also shown to affect the magnitude of the angle.

This study does not refute the distal metatarsal articular angle as an entity, but does confirm the inaccuracy of extrapolating the DMAA from plain AP radiographs.


S Gwilym P Loxdale G Lavis R Sharp P Cooke

Introduction: Lesser toe deformities which require surgery are often treated using a technique of interphalyngeal joint fusion. This procedure is an effective way of reducing the deformity and pain associated with lesser toe deformity but necessitates internal fixation until fusion is achieved. The Kirschner wire used to provide peri-operative stability is undesirable for a number of reasons, most importantly, the risk of interosseous infection and the lack of patient satisfaction due to the need for a second procedure for the wires removal. The ‘Oxford’ procedure was developed by the senior author (PHC) both in an attempt to remove the need for Kischner wire fixation and to maintain some mobility at the interphalyngeal joint.

Patients and methods: Between January and October 1994, 14 patients underwent ‘Oxford’ procedures on isolated lesser toe deformities. Their mean age was 59 at the time of surgery (range 26 – 79, 3 male and 11 female). Each patient was reviewed in November 1995 and an assessment was made of their post-operative pain levels, function, footwear, cosmetic appearance, time to return to work and any complications they had experienced. In March 2005 (ie: at least 10 years postop) an attempt was made to review these patients and make assessments of their pain in the operated toe, any subsequent surgery in that, or other toes, and the stability of the toe. In addition, an assessment was made of the patients view of the cosmetic outcome and their satisfaction levels. 12 patients were successfully contacted and reviewed.

Results: All 12 patients were satisfied with their long term results in terms of pain relief and cosmesis.

Conclusion: The ‘Oxford’ proceedure for lesser toe deformities has good long term clinical results and avoids k-wire fixation.


J Calder T Kane E Gardner

Introduction: A recent clinical study has suggested that topical GTN may improve the outcome of non-insertional Achilles tendinopathy. The mechanism for this improvement is obscure but is thought to be due to modulation of local nitric oxide (NO) levels. The purpose of this study was to assess the clinical and histological results of topical GTN for non-insertional Achilles tendonitis.

Methods: 40 patients with non-insertional Achilles tendonitis underwent standard non-operative therapy. 20 patients also used topical GTN daily. AOFAS, AOS visual analogue scores and SF36 forms were completed pre-treatment and 3 months later.

Patients who failed conservative treatment and underwent surgery had histological examination of achilles tendon and histochemical analysis for isomers of NOS (eNOS and iNOS) as a marker of NO production.

Results: There was an overall improvement in symptoms in both groups but no significant difference in the improvement bewtween them – there was no additional benefit in using GTN patches. 4 patients also had to stop using patches within 3 weeks because of headaches.

Histological examination did not show any difference in collagen synthesis or remodelling between the 2 groups and there was no evidence of stimulated wound fibroblasts in the GTN group. There was no difference between the groups in the expression of eNOS or iNOS.

Conclusion: This study fails to demonstrate any improvement in symptoms when using GTN patches. There is no histological evidence that GTN promotes degenerate tendon to stimulate wound fibroblasts and increase collagen synthesis and remodelling. GTN patches do not appear to modulate the expression of NOS enzymes in diseased Achilles tendon. The use of GTN patches in the treatment of non-insertional Achilles tendonitis remains questionable and the role of NO as a mediator of inflammatory response remains elusive.


J J G Malal J Shaw-Dunn C S Kumar

Aim: Chevron osteotomy is a commonly performed procedure for the treatment of hallux valgus and results in AVN of the first metatarsal head in up to 20% of cases. This study aims to map out the arrangement of vascular supply to the first metatarsal head and its relationship to the limbs of the chevron cuts.

Methods: 10 cadaveric lower limbs were injected with an Indian ink – latex mixture and the feet dissected to evaluate the blood supply to the first metatarsal. The dissection was carried out by tracing the branches of dorsalis pedis and posterior tibial vessels. A distal chevron osteotomy through the neck of the metatarsal was mapped and the relationship of the limbs of the osteotomy to the blood vessels was recorded.

Results: The first metatarsal head was found to be supplied by branches from the first dorsal metatarsal, first plantar metatarsal and medial plantar arteries of which the first one was the dominant vessel in 8 of the specimens studied. All the vessels formed a plexus at the plantar – lateral aspect of the metatarsal neck, just proximal to the capsular attachment with varying number of branches from the plexus then entering the metatarsal head. The plantar limb of the proposed chevron cuts exited through this plexus of vessels in all specimens. Contrary to the widely held view, only minor vascular branches could be found entering the dorsal aspect of the neck.

Conclusion: The identification of the plantar – lateral corner of the metatarsal neck as the major site of vascular ingress into the first metatarsal head suggests that constructing the chevron osteotomy with a long and thick plantar arm exiting well proximal to the capsular attachment may decrease the incidence of AVN.


K Mannan C Belcham H Beaumont J Ritchi D Singh

Purpose: Evaluation of a hands free crutch. This interesting device is intended for patients who have undergone foot and ankle surgery and should be non-weight bearing. It involves a knee tray attached to a vertical beam with a rubber foot. The crutch is strapped to the lower limb and weight is transferred though the proximal tibia.

Methods: Five Volunteers were assessed using the crutch, the K9 walker and 2 standard crutches in a simulated environment.

A comparison was made between this device and the K9 walker which has been shown to be a liberating walking aid indoors. Tasks from activities of daily living, productivity and transfers were included. Assessment was undertaken by the Occupational Therapy Team.

The hands free crutch was also compared with non weight bearing using two crutches to gauge performance outdoors. Assessment of ease of use and safety was undertaken by the Physiotherapy Team.

Results: Domestic chores including cleaning, cooking and shopping were possible using this device. Sitting activities were noted to be more difficult, because of the necessity to remove the crutch on each occasion.

Although speed was significantly greater (p< 0.0001.) using two crutches, the hands free crutch permitted safe outdoor mobilisation on even or uneven ground, up and down slopes with a gradient of 1 in 10 and up and down stairs. Good single leg stance stability was predictive of ease of use and safety for the hands free crutch.

Discussion: The hands free crutch is suited to motivated and physically able patients. Other lower limb pathology contraindicates the use of this device, but in patients with upper limb pathology it would permit non-weight bearing mobilisation. Good balance is paramount and perhaps a falls risk assessment should be performed prior to use.


G Holt M Kay R McGrory S Kumar

Introduction: Patients undergoing surgery to the foot frequently ask when it is safe to return to driving. The ability to drive is important both in social and economical terms. There is currently little data in the literature relevant to foot surgery. We are conducting a prospective cohort control study to asess the effect of forefoot surgey on break-response time. Methods- Individuals attending for first MTP joint arthroplasty and SCARF/Chevron osteotomies for hallux valgus are recruited. A driving simulator was constructed consisting of a steering wheel, foot pedals, an LCD display, a CPU and a control unit. The patient follows an image on the LCD screen using the steering wheel. The examiner then randomly initiates the machine and a stop sign is displyed. The patient would then release the accelerator pedal and depress the brake. The CPU claculates the “respone-time”, the “break-time” and total breaking time. In addition the “stick test” and “stand test” were performed as further measures of lower limb function. Each individual was assessed pre-operatively and at 2 and 6 weeks postoperatively. Both drivers and non-drivers are included and a control population of age and gender matched individuals was included for comparison. Results – 25 individuals are currently enrolled as study cases, 12 of which have 2 week follow-up and 3 have completed the study. Control data is being collected.

Conclusion: Early results indiciate that break response time is increased at 2 weeks post-operatively, however this returns to pre-operative levels by 6 weeks. (204ms vs 256ms vs 206ms) These early results may be validated when all individuals have completed the study. Further study of the period 2–6 weeks after surgery will now be subject to study to assess the optimum time to return to driving.


S Lines I Winson M Bradley

Morton’s syndrome is an entrapment of a digital nerve between the metatarsal heads in the foot causing pain between the metatarsal heads. 41 subjects with signs and symptoms of Morton’s syndrome were prospectively examined with an ultrasound scan and the size of the bifurcation of the interdigital nerve was recorded if it was visible. Each subject completed a Visual Analogue Scale and short form McGill Pain Questionaire before an injection of local anaesthetic and corticosteroid was administered. The subjects were reviewed after 6 weeks and the pain scores repeated.

26 subjects had positive ultrasounds with a mean width of 5.1 mm, range 2.7–9.8 mm and 15 subjects had negative ultrasounds. Differences in mean ranks of VAS scores between the two groups were borderline statistically significant for scores before injection (p=0.064). Difference in mean rank of VAS score was significant after injection (p=0.013).

Differences in mean ranks of MPQ scores were borderline statistically significant for changes in scores (p=0.062). Difference in mean rank of MPQ score was significant after injection (p=0.007). None of the correlations between nerve width and any of VAS or MPQ outcome measures were statistically significant.

This study demonstrates that the larger the neuroma on the ultrasound, the more painful it is for the patient. This study suggests that patients who have a small or absent neuroma demonstrated on the ultrasound scan are more likely to have their pain reduced to an acceptable level with an injection of local anaesthetic and corticosteroid than those patients with a large neuroma. Ultrasound examination is a useful tool in the management of patients with Morton’s syndrome.


M Costa F Robinson S Donell L Shepstone R Chester

We performed two independent randomised controlled trials to assess the potential benefits of immediate weight-bearing mobilisation for Achilles tendon ruptures. The first trial on surgically treated patients provides strong evidence of improved functional outcome for patients mobilised fully weight-bearing after operative repair of their Achilles tendon rupture. The two cases of re-rupture in the treatment group suggest that careful patient selection may be required as patients need to follow a structured rehabilitation regime.

The second trial performed upon non-operatively treated patients provides only weak evidence of a functional benefit from immediate weight-bearing mobilisation. However, the practical advantages of immediate weight-bearing did not predispose the patients to a higher complication rate. In particular there was no evidence of tendon lengthening or a higher re-rupture rate. We would therefore advocate the use of immediate weight-bearing mobilisation for the rehabilitation of all patients with rupture of the Achilles tendon.


P Singh N Perera

Background: There is increased concern regarding radiation exposure to surgeons using fluoroscopic guidance throughout various procedures. However, relatively little information exists on the level of radiation exposure to the foot and ankle surgeon during fluoroscopically assisted foot and ankle surgery.

Methods: We are conducting an ongoing proespective study to measure radiation exposure to the hands of a single orthopaedic foot and ankle surgeon (RD). Over a 12-month period, thermoluminescent dosimeter rings are worn on the little finger of each hand of the operating surgeon. The rings are changed at six week intervals. Measurement of the overall radiation exposure is being recorded over this time period.

Results: This is an ongoing prospective study started in December 2004. We are measuring: total number foot and ankle cases using fluoroscopy, the total screening time for foot and ankle procedures, the mean screening time per procedure and the total radiation exposure to the thermoluminescent dosimetry rings.

Conclusion: Preliminary results show that radiation exposure is well below the current annual dose limit. In our study, radiation exposure during orthopaedic foot and ankle procedures is expected to comply with current recommendations of the European Committee on Radiation Protection and is well below dose limits set by the International Commission on Radiological Protection.


S Godey R Tandon O Thomas

Claw toes are treated by a variety of soft tissue and bony proceduresbased on the severity of the deformity. We evaluated the results of Stainsby procedure for claw toes. This is a retrospective analysis of the results of Stainsby procedure for claw toes of the foot done by a single surgeon over a 10 year period. All patients who had claw toes,secondary to Rheumatoid and Non rheumatoid causes and treated by this procedure were included in the study. All the patients operated between Jan 1995 -Dec 2004 and who had minimum follow-up of 6 months after surgery were included in the study. Follow up evaluation was by clinical examination, review of case notes and telephone conversation.

42 patients underwent this procedure of which 38 were available for evaluation. Average follow-up was 43.5 months (6–110months). 26 rheumatoid and 21 non-rheumatoid feet were evaluated based on the AOFAS score. The mean AOFAS score was 76.5. The scores for the Rheumatoid and Non-Rheumatoid groups were 81.5 and 72.6 respectively.81% were satisfied with the result of the operation and 83% would recommend this surgery for friends and relatives. Six patients had superficial infection, 2 had broken k-wires, 2 had DVT, and 2 had recurrence of deformity.

We conclude that Stainsby procedure for claw toes is a procedure which has good results in the long term and can be taken up as a procedure of choice for severe claw toes.


M Costa D Kay S Donell F Robinson

One of the factors that influence the outcome after Achilles tendon rupture is gait abnormality. We prospectively assessed 14 patients with Achilles tendon rupture and 15 normal control subjects using an in-shoe plantar pressure measurement system. There was a significant reduction in peak mean forefoot pressure in the early period of rehabilitation (p < 0.001). There was a concomitant rise in heel pressure on the injured side (p=0.05). However, there was no difference in cadence, as determined by the duration of the terminal stance and pre-swing phases as a proportion of the total stance component of the gait cycle. The forefoot pressure deficit in the Achilles tendon rupture group was smaller when assessed six months after the injury but was still significant (p=0.029). Pedobarographic assessment of patients after Achilles tendon rupture confirms that there are marked abnormalities within the gait cycle. Rehabilitation programmes which address these abnormalities may improve outcome.


A Shah L Murray M Siddique

Purpose: The purpose of this study was to assess the subjective, clinical and radiological improvement in patients with moderate to severe hallux rigidus undergoing Proximal Phalangeal Dorsomedial Closing-wedge Osteotomy with Cheilectomy.

Methods: Between March 2003 and November 2004, 17 patients (18 feet) underwent Proximal Phalangeal Dorsomedial Closing-wedge Osteotomy with Cheilectomy, 14 were available for clinical follow-up; pre and post-operative X-rays were available for all of them.

The Clinical assessment was based on modified American Orthopaedic Foot and Ankle Society’s hallux-metatarsophalangeal scale. The subjective assessment was done by a questionnaire and radiological assessment was done by using digital radiographs.

Results: Out of the 18 feet we studied, 1 was of Grade 1, 9 of Grade 2 and 8 of Grade 3. 12 out of 14 patients (85%) were satisfied with the outcome after an average follow-up period of 14 months. There was an increase in the Mean mAOFAS score of 49.6 (from a mean score of 26.2 to 75.8); the improvement in pain score was 27.4. With a mean osteotomy thickness of 1.78 mm, the proximal phalangeal length was decreased by a mean of 3.7mm. The medialization achieved in the men M1-P1 angle was 6.8 degrees. There was a highly significant gain of 25 degrees in Mean Dorsiflexion which cannot be explained by a mean increase of only 0.9 mm in the lateral dorsal joint space attributable to cheilectomy.

Conclusion: Dorsomedial Proximal Phalangeal Closing-wedge Osteotomy combined with Cheilectomy gives good subjective and clinical results regarding satisfaction, pain relief and gain in dorsiflexion; at least in the short-term. This gain in movement might be explainable by an improved EHL lever-arm resulting from dorsome-dial nature of the phalangeal osteotomy.


D MacDonald G Holt K Vass A Marsh S Kumar

Lumps of the foot present relatively infrequently to the orthopaedic service. There have been very few published studies looking at presenting characteristics or the differential diagnosis of such lesions. We report our experience of foot lumps treated surgically looking at the patient demographics, presenting characteristics, diagnoses encountered and the diagnostic accuracy of the surgeon. All patients who underwent excision or biopsy of a foot lump over a period of 4 years were studied; 101 patients were identified. Average age was 47.3 years (range 14–79); there was a significant female preponderance with 73 females and 28 males (p< 0.0001). Pain was the single most common presenting complaint followed by footwear problems. Only three patients attended because of cosmetic reasons and neurological symptoms were very rare with only one patient complaining of paraesthesia. Certain lesions were more commonly encountered in specific zones of the foot. 32 different histological types were identified, ganglion cysts were the most commonly encountered lesions and there was only one malignant lesion encountered in this study. Only 58 out of the l01 lumps were correctly diagnosed prior to surgery.

We have shown that there are a wide variety of potential diagnoses, which have to be considered when examining a patient with a foot lump. There is a low diagnostic accuracy for foot lumps and therefore surgical excision and histological diagnosis should be sought if there is any uncertainty.


N Maffulli V Testa G Capasso F Oliva A Sullo

Objective: To report the outcome of surgery for chronic recalcitrant Achilles tendinopathy in sedentary and athletic subjects.

Design: Case control study

Participants: We matched each of the 61 non-athletic patients with a diagnosis of tendinopathy of the Achilles tendon with an athletic patient with tendinopathy of the main body of the Achilles tendon of the same sex who was within two years of age at the time of operation. A match according was possible for 56 patients (23 males and 33 females). 48 sedentary subjects and 45 athletic subjects agreed to participate.

Main Outcome Measure: Outcome of surgery, return to sport, complication rate.

Results: Non-athletic patients were shorter and heavier than athletic patients. They had greater BMI, calf circumference, side-to-side calf circumference differences, and subcutaneous body fat than athletic patients. Of the 48 sedentary patients, only 25 reported an excellent or good result. Of these, three had undergone a further exploration of the Achilles tendon. The remaining patients could not return to their normal levels of activity. In all of them, pain significantly interfered with daily activities.

Conclusions: Non-athletic subjects experience more prolonged recovery, more complications, and a greater risk of further surgery than athletic subjects with recalcitrant Achilles tendinopathy. Key words: Achilles tendinopathy, surgery.


B Yates D Williamson

Purpose: An audit was undertaken to evaluate the patients’ experience of foot surgery at the great Western Hospital in 2004 following the appointment of a podiatric surgeon to the orthopaedic department.

Method: The first 100 patients that were operated on by the podiatric surgeon (Group 1) were matched by OPCS code to a randomly selected patient cohort that had been operated on by orthopaedic surgeons (Group 2). All patients were at a minimum of 6 months post-surgery (range 6–10 months Gp. 1, 11–20 months Gp. 2). The audit department sent out an anonymous questionnaire relating to the patients’ experience both before and after their surgery as well as current levels of satisfaction with the outcome of their surgery.

Results: The response rate was 64% in Gp.1 and 68% in Gp.2.

The patients’ overall satisfaction with the result of their foot surgery was determined using a Likert scale and the results can be seen in Table 1.

Patients in the podiatric surgical group were significantly more satisfied with the result of their foot surgery than those in the orthopaedic group (p< 0.008; Mann Whitney U test).

Similar statistically significant differences were also seen between the two groups relating to patient satisfaction with their pre and post-operative consultations and information concerning their proposed surgery and its outcome.

Conclusion: The results of this audit suggest that the satisfaction of patients following foot surgery can rise significantly following the appointment of a podiatric surgeon to a general hospital orthopaedic department.


V Kumar R Bhattacharyam F Attar A Hameed I McMurty

CT- scan as an management tool is being used extensively in managing calcaneal fractures. We set out to see if a CT-scan makes any difference to the management plan as obtained by looking at the plain radiograph. We also looked at the correlation with the actual management.

Methodology: This was a retrospective study involving 24 patients with fracture of the calcaneum. These patients had both a plain radiograph and a CT- scan to help decide on management. The actual management that each of these patients had was documented. Three consultants who were blinded to the actual management and names of the subjects were independently asked to grade the radiographs, as operative or non-operative. They were then similarly, asked to decide on operation or no-operation based on blinded CT- scans. The data obtained from the three observers were compared to the actual management and were subjected to statistical analysis.

Results: As the data was categorical and matched, the Mcnemars test was used to test the association between the management plan obtained from the radiographs and the management plan obtained from the CT scans, for each consultant. They were also compared with the actual management. The statistical analysis showed that there was no statistically significant association between the management decision obtained from the radiographs and the CT san, for all three observers. Radiograph and CT scan based management decisions also did not correlate with the actual management.

Conclusion: The CT scan should only be done when a definite decision is made to operate on a patient, based on plain radiographs. Calcaneal fractures which are decided not to operate, based on X rays, should not have a CT scan as a routine as it provides no valuable additional information.


V Kumar F Attar M Maru A Adedapo

Aim: Our aim was to measure plantar foot pressures in normal individuals and to compare them with variations in patients with metatarsalgia.

Methodology: We measured the plantar foot pressures in different parts of the foot in normal subjects of various ages and then compared this with foot pressures of patients with metatarsalgia. For measurement and statistical analysis, the plantar contact of the foot was divided into six anatomical divisions. The foot pressures were measured under the hallux, head of first metatarsal, over heads of second, third and fourth metatarsals, the fifth metatarsal, midfoot and hindfoot. This was measured using the FSCAN insole pedobarograph system (Tekscan, Inc, Boston, MA).

The foot pressures were measured in Kilopascals(Kpa). Independent T-tests was used to compare mean pressure distributions in the six anatomical divisions. We found the mean pressures through the 5th metatarsal head – 217(t=−2.32,p< 0.05) and midfoot 94(t=−3.17, p< 0.05), were significantly higher when compared to pressures in normal subjects (table 1).

Conclusion: We have demonstrated increased pressures transmitted through the outer aspect of the sole of the foot, in patients suffering from metatarsalgia. This can be used further to plan any foot- orthosis or surgery to distribute pressures more evenly across the sole of the foot.


C Nguyen D Singh M Harrison G Blunn I Dudkiewicz

Introduction: Many mini compression screws are now available for fixation in procedures such as metatarsal osteotomies or arthrodeses of the foot.

The aim of the current study is to compare the compression forces achieved by mini compression screws on cortical and cancellous bone models.

Material and Methods: The screws that were tested are listed in the table below. The compression forces were tested by inserting a pressures load measurement cell between longitudinally-split sheep tibia as a cortical bone model and longitudinally split retrieved femoral heads as a cancellous bone model.

Results: The Headed AO 3.5 mm cortical screw gave the best compression force and the Bold was the weakest, both in cortical and cancellous bone. The relative compression forces of the other tested screws were different between cortical and cancellous bone. Compression with the headless screws was lost as soon as the screw penetrated through the cortex in the cortrical bone model.

Conclusions: The indications for using headless self-tapping screws should be reserved for fixation of cancellous bone or of metatarsal or Akin osteotomies where compression is not required for union. When compression is important, such as in MPJ, tarso-metatarsal or talonavicular arthrodeses, Headed AO 3.5 mm or 2.7 mm cortical or 4 mm cancellous screws, which give better compression, should be used.


W S Khan M. Aggarwal C Warren Smith

Proximal fifth metatarsal fractures distal to the tuberosity, also known as Jones’ fractures, are troublesome fractures to manage with a high incidence of delayed union and nonunion.

We conducted a retrospective study of 32 patients with fractures of the fifth metatarsal distal to the tuberosity over a three year period. The aim was to assess healing with non-weight bearing and variations of weight bearing mobilization including minimal, partial and full weight bearing. This is one of the largest reported series of such fractures. These fractures were classified as acute fractures (14 fractures), fractures with features of delayed union (15 fractures) and fractures with features of nonunion (three fractures) at presentation according to the radiological classification used by Torg in 1984. These patients were treated in a plaster cast and mobilised either non-weight bearing or with variations of weight bearing. These patients were followed up for a mean of 16 months.

Our findings correspond with those observed by Torg and we describe a correlation between the radiological appearance of the fracture at presentation and the clinical course. Prevailing guidelines for the management of these fractures are ambiguous. A standardized classification is important because there is great variability in the types of fractures and appropriate treatment. It is important that radiological features are correlated with clinical features and appropriate treatment instituted. The treatment of choice for acute fractures is immobilization of the limb in a below-knee non-weight bearing plaster for 6 to 8 weeks. Fractures with delayed union may eventually heal if treated non-operatively, although this may take up to 20 weeks. An active athlete will benefit from early surgery. Fractures with symptomatic nonunion require surgery.


H Hassouna D Singh

Morton’s Metatarsalgia is a painful condition and can often be debilitating. The value of surgical exicion has been doubted due to low success rate of surgical intervention.

Objective: The purpose of this study is to examine the variation in the management steps of Morton’s Metatarsalgia.

Methods: Several Surgeons from different European countries answered a questionnaire in regard to their routine management of a typical Morton’s Neuroma patient.

Results: 25 surgeons (100%) stated they would routinely elicit intermetatarsal tenderness in comparison to 14(56%) and 10 (40%) surgeons who would routinely elicit Intermetatrsal tenderness and Mulder’s click respectively. The majority of them (84%) will routinely request plain foot radiograph, while 7 surgeons(28%) uses ultrasound routinely. Coservative management is initiated by 16 surgeons(64%). Local injection was first line of treatment among 13 surgeons (56%). Surgical treatment is favoured by 10 surgeons(40%), while only one surgeon (4 %) would use ultrasound guided injection routinely. The popular surgical approach is dorsal incision (75%). If surgical option was chosen then neurectomy is attempted by 17 (68%) surgeons.

Conclusion: Considerable variation exists among continental surgeons in their initial management of a typical Morton’s Neuroma patient. This is probably due to lack of understanding of the true aetiology of the Morton’s “Neuroma”.


S Hakkalamani K Meda V Prasanna J Stamer

Objective: To assess functional outcome and complications in patients with Weber C fracture following syndysmotic screw removed.

Patients & Methods: Forty three consecutive patients with closed Weber C type ankle fractures between 2002–20003 were studied. The syndysmotic screw was removed at 6–12 weeks time post operatively. Postoperative complications and functional outcome were studied.

Results: Following removal of the syndysmotic screw 6 patients had superficial wound infection, 4 patients had pain due to instability, one patient had DVT and one patient had broken screw. The functional outcome using ankle scores compared to the other studies in the literature did not show any significant difference.

Conclusion: Syndysmotic screw removal has significant morbidity. Guidelines with randomised control studies are recommended.


B Sarai A Ebinesan G Walley D Miller D McBride N Maffulli

Introduction: We reviewed the complications and recovery of patients treated for Achilles tendon rupture by percutaneous repair, open repair, and non-operative management in a tertiary referral centre between 2001 and 2003.

Materials and Methods: We identified patients who underwent Achilles tendon rupture repair by percutaneous or open methods from the logbooks of Consultants and the operating theatre register. We used plaster room records were also used to identify patients who received non-operative treatment. We collated demographic and management details, and compared them with published rates relating to average age range, demographic, and management details.

Results: In the 20 patients who underwent open repair, one (4.8%) patient sustained a re-rupture, four (19%) sustained minor complications, and one (4.8%) had a major complication. In the 31 patients who underwent percutaneous repair, one (3.2%) patient sustained a major complication, six (19.4%) patients experienced minor wound complications, and there were no re-ruptures. In the 12 patients who underwent conservative management, re-ruptures occurred in one patient (8.3%), minor complications occurred in five patients (41.7%), and there were no major complications. The median recovery time in the open, percutaneous and conservative groups was 25 weeks, 26 weeks and 18.5 weeks respectively.

Discussion and Conclusion: In our setting, percutaneous repair is the most successful management method, with no re-ruptures and very few complications. Although conservative management produced the highest rate of complications, each patient will have different needs due to their age, occupation or level of sporting activity. Ultimately, the decision of the management regime used probably lies with the patient.


J J G Malal C S Kumar

Shape memory phenomenon whereby the metal changes its characteristics depending on the ambient temperature it is exposed to is well described in the metallurgical literature. In cold conditions (0–5° C) the alloy becomes plastically deformable and its shape can be changed at will, but would rapidly regain its original shape and strength at higher temperatures. This study assesses the effectiveness of shape memory staples as a method of internal fixation in foot and ankle surgery.

All patients who underwent foot and ankle surgery in which Memory® staples were used for fixation were included in the study. The patients were evaluated with regard to period of immobilisation in cast, period of restricted weight bearing and time to radiological joint fusion or union of osteotomy.

Memory® staples had been used in a total of 40 procedures; 13 procedures (6 MTPJ fusions, 7 Akin osteotomies) were done in the forefoot while the rest were carried out in the mid or hind foot. Bone grafting was used only in one hind foot arthrodesis. A strong arthrodesis or union was achieved in all the patients. The average time to fusion was 7.2 weeks (range 6–12) with an average period of immobilisation of 4.3 weeks (range 0–12). The average time to full weight bearing was 5.2 weeks (range 0–6). Breakage of the staple was noticed in one patient but the joint went on to unite satisfactorily. Staple back out or displacement was not noticed in any of the cases.

The early experience with the use Memory® staples in foot and ankle surgery is encouraging; we did not encounter any technical problems and there is a suggestion that these implants may reduce the time to fusion/ healing thereby reducing the recovery time following foot and ankle surgery.


S Godey R Tandon O Thomas

Claw toes are treated by a variety of soft tissue and bony proceduresbased on the severity of the deformity. We evaluated the results of Stainsby procedure for claw toes. This is a retrospective analysis of the results of Stainsby procedure for claw toes of the foot done by a single surgeon over a 10 year period. All patients who had claw toes, secondary to Rheumatoid and Non rheumatoid causes and treated by this procedure were included in the study. All the patients operated between Jan 1995 -Dec 2004 and who had minimum follow-up of 6 months after surgery were included in the study. Follow up evaluation was by clinical examination, review of case notes and telephone conversation.

42 patients underwent this procedure of which 38 were available for evaluation. Average follow-up was 43.5 months (6–110months). 26 rheumatoid and 21 non-rheumatoid feet were evaluated based on the AOFAS score. The mean AOFAS score was 76.5. The scores for the Rheumatoid and Non-Rheumatoid groups were 81.5 and 72.6 respectively.81% were satisfied with the result of the operation and 83% would recommend this surgery for friends and relatives. Six patients had superficial infection, 2 had broken k-wires, 2 had DVT, and 2 had recurrence of deformity.

We conclude that Stainsby procedure for claw toes is a procedure which has good results in the long term and can be taken up as a procedure of choice for severe claw toes.


A Bhargava E Greiss

Introduction: Every ten seconds, somewhere in the world, someone dies of tobacco-related causes. The adverse effects of smoking on the cardiovascular, respiratory, and immune systems have been well documented. Results of foot surgery are also gravely affected by cigarette smoking, with poorer clinical outcomes, lower rates of osteotomy union, bony fusion and higher rates of postoperative infection. However, data on surgeon’s awareness and their practices to overcome the adverse effects of smoking in elective foot surgery is limited.

Aim: The purpose of this study was to report the results of a survey of experienced foot and ankle surgeons regarding their awareness about detrimental effects of smoking and the measures they take in their practice to prevent them.

Methods: A survey of members of British Foot and Ankle Society was done to document surgeon’s awareness and attitudes towards detrimental effects of smoking in patients undergoing elective foot surgery and the measures they take to prevent these problems. Survey was returned by 104 of the 225 surgeons (47%).

Results: One hundred and two (99%) of the surgeons were aware of the damaging effects of smoking in foot and ankle surgery. Eightynine (84%) of these recorded the smoking habits of their patients in their dictated notes. However, only 9% respondent admitted recording the smoking habits of their patients in consent form and warn them about forthcoming risk of complications at the time of consenting. Only twentyfour (23%) had varying protocol’s to prevent smoking related operative complications.

Conclusions: Most of the surgeons appreciate the harmful effects of smoking. However they are unaware of the extent to which it causes problems. Majority of the members would like the society to propose a unified policy or evidence based guidelines to deal with smoking related problems in foot surgery.


N Maffulli W Leadbetter

Introduction: Neglected Achilles tendon ruptures are a management challenge. Several surgical techniques have been described. A two centre, two surgeon, two year longitudinal study was undertaken to report the results of reconstruction of neglected Achilles tendon rupture using a free autologous gracilis tendon graft

Methods: Fourteen patients underwent surgery for a neglected rupture of the Achilles tendon occurring between 65 days and nine months before the operation. All were prospectively followed up for two years.

Results: No patients experienced any problems in the wound used to harvest the tendon of gracilis. Four patients were managed conservatively following a superficial infection of the achilles tendon surgical wound. No patients developed a deep vein thrombosis or sustained a re-rupture. All patients were able to walk on tiptoes, and no patient used a heel raise or walked with a visible limp. The maximum calf circumference remained significantly decreased in the operated leg at latest follow up. The operated limb was significantly less strong than the non-operated one.

Conclusions: The management of neglected subcutaneous tears of the Achilles tendon by free gracilis tendon grafting is safe but technically demanding. It affords good recovery, even in patients with a neglected rupture of nine months’ duration. These patients should be warned that they are at risk of post-operative complications, and that their ankle plantar flexion strength can remain reduced.


A Young

Thirty patients underwent tibio-talo-calcaneal fusion using an interlocking arthrodesis intramedullary nail device with locking screws. Although the nail is described as being stiffer in flexion, rotation and cantilever bending it was noted that the placement of the locking screw holes were not sufficiently in-tune with the variations found in nature. The placement of the holes and locking screws with relation to the heights of the talus and calcaneum were measured on post operative xrays and conclusions drawn from the variations found. It was felt that the intramedullary nail is a good device when used for tibio-talo-calcaneal fusion but that the design could be improved in order to improve patient outcome.


H Kurup G Taylor

Ankle replacements appear to offer a good alternative to fusion in most arthritic conditions. Use of mobile bearings have significantly improved results of ankle replacement. These have a significant minor complication rate including nerve injury, fractures. One of the significant complications noted in our series was medial impingement. 34 Buechel-Pappas total ankle replacements performed by the senior author from October 1999 to May 2004 were reviewed retrospectively. Mean follow up of 2.8 years. 8 patients reported medial impingment symptoms at follow up. 3 patients underwent repeat surgery for this problem. One patient underwent arthroscopic debridement of scar tissue and impinging bone by another surgeon which gave good symptomatic relief. Two other patients had tibialis posterior tendonitis and underwent surgical decompression of the tendon. Both were found to be having degenerative tendons with partial tears. We discuss the findings, literature review and other complications of ankle replacements as well. Whether medial impingement is due to implant design or inherent pathology of ankle has to be studied further. Other implant designs like Agility may treat arthritis in medial and lateral gutters but can still cause soft tissue impingement. Whether these are due to implant design, residual arthritis in medial recess or soft tissue pathology is uncertain. This may be caused by the cylindrical shape of talar component (the physiologic talus has a cone shape with smaller radius on medial side). This has not been proven yet, but has been addressed in newer designs like Salto and Hintegra prostheses.


A Crombie C Kumar

Background: Since 2003 we have offered correction of bilateral hallux valgus to suitable patients as a daycase but there is nothing in the literature to support this as safe practice. Two published series support unilateral hallux valgus surgery as a daycase. We prospectively evaluated 30 bilateral daycase patients assessing complications and overall satisfaction rating.

Methods: The study group comprised 15 bilateral Scarf osteotomies, 9 bilateral Chevron osteotomies, 4 unilateral Scarf plus unilateral Chevron osteotomies, 1 bilateral 1st MTP joint fusion and 1 bilateral Lapidus procedure. All surgery was performed as a daycase under GA and ankle block. All patients were evaluated clinically and radiologically pre & post-operatively and had AOFAS scores measured. 21 patients were telephoned on the 3rd post-operative day to document their pain scores (0–10) and all patients responded to a patient satisfaction questionnaire at their discharge around 4.5 months.

Results: 18 of the 21 patients interviewed on day 3 had mild pain (0–4) as their maximum pain score. 3 reported problems (2 of pain and 1 of poor mobility). There was one unilateral superficial wound infection which required oral antibiotics. No other patients required to call or attend their GP nor attend A& E. The mean overall patient satisfation rating (0–10) was 8.8 (median 9). If having similar repeat surgery 4 of the 30 patients (13%) would prefer an overnight stay. The reasons given by these 4 patients were: pain (1), poor mobility (1), a desire to be looked after by the nursing staff (2).

Conclusions: Bilateral hallux valgus surgery can be performed safely as a daycase and with acceptable levels of patient satisfaction. It does not appear to result in an increased complication rate. To our knowledge this has not been previously documented in the literature.


R Kotnis S David S Ostlere K Willet

Hypothesis: If the lower re-rupture in operative treated patients was an effect of tendon-end apposition, then patients in whom that could be demonstrated in equinus by ultrasound could be equally well treated non-operatively without the attendant surgical risk.

Method: All patients undergoing ultrasound for a suspected Achilles tendon repair between January 2000 – 2005 were included. Patients with a residual gap, 5mm or more in equinus; were treated by surgical repair. Those with a gap of less than 5mm were treated non-operatively. We excluded patients with no rupture, partial rupture and musculo-tendinuous junction (MTJ) tears. We recorded the following: clinical findings, ultrasound measurements of tendon gap in neutral and equinus, distance of rupture from distal insertion, the treatment and complications. All patients were followed up to a minimum of 6 months.

Results: 156 patients were treated for a clinical Achilles tendon rupture during the study period. We excluded 5 patients with no rupture, 15 with a MTJ tear, 7 with a muscle tear and 4 patients did not follow the protocol. 125 patients comprising 88 males and 37 females were entered into the study. 67 patients were treated operatively (37 open, 30 percutaneous) and 58 non-operatively. There was no significant difference between the 2 groups with respect to age, sex and injury mechanism. There were 2 re-ruptures in the non-operative group and 1 with surgery. The operative group had 2 patients with superficial wound infection and 2 with temporary dorsal foot numbness. One patient in the non-operative group had a DVT. There was no significant difference for any of the complications between the two groups.

Conclusions: It may be possible to reduce the risk of re-rupture and surgery using dynamic ultrasound to determine which treatment the patient receives.


J Ritchie D Singh

Introduction: Adolescent peroneal spastic flatfoot (PSF) is often regarded as synonymous with tarsal coalition. Inflammatory arthropathies, infections and tumours may, however, all present in this way, and in a few patients with PSF no definitive pathology may be identified.

We aim of to evaluate the causes of adolescent PSF and to develop an an algorithm for its investigation and the management of those patients in whom no underlying pathology is identified.

Methods: All adolescent patients presenting to the senior author with PSF over a two year period were evaluated first for tarsal coalition by means of clinical examination, plain x-rays and CT scanning. If this proved inconclusive an MRI scan was performed and bloods sent for inflammatory and infective markers. If these too identified no treatable cause the patients were treated with a manipulation under anaesthetic, injection of steroid and local anaesthetic into the subtalar joint and immobilization in a below knee cast for 4 weeks. They then received physiotherapy and a talar neutral orthosis. Follow-up was at 4 weeks post-injection and continued until symptoms resolved.

Results: Five patients were found to have PSF with no identifiable cause. All were male, aged 12–17 at presentation. Four completed the treatment. Mean final follow-up was at 10 months post-procedure. All patients reported relief of pain following the procedure and returned to normal activity. At final follow-up, three were still participating in regular sport. One patient suffered a recurrence of his pain.

Conclusion: Adolescent peroneal spastic flatfoot is often, but not always due to tarsal coalition.

If this and other treatable causes have been excluded, treatment with the regime described may give good symptomatic relief in the short to medium term.


D Osarumwense D Jena A Feldman

Background: Ankle fractures in adults are an increasing part of the workload of orthopaedic surgeons today. Stable ankle fractures are usually managed conservatively and followed up in the fracture clinic to identify any later displacement which may lead to the need for surgical treatment. the guidelines for follow up varies from place to place with equally varying outcomes. the aim of this study was to look at the pattern and outcome of follow up of these fractures and also the influence, if any, of serial radiological imaging during this period.

Methods: We retrospectively reviewed the follow up of patients who were refered to the clinic as stable ankle fractures and who were treated conservatively following their first clinic attendance. the period covered was April 2002 to march 2003 and we also assessed the documentation of medial side tenderness from the casenotes.

Results: 66 patients were identified consisting of 44 Weber A, 20 Weber B and 2 Weber C fractures with an average follow up of 10weeks. 82% of cases had documented medial side tenderness. None of the Weber A fractures displaced, irrespective of weight bearing instructions and medial side tenderness. Only 2(10%) of the Weber B and 1 (50%) of the Weber C fractures required surgical intervention due to displacement detected after clinic review at week one.

Conclusion: Weber A fractures are inherently stable injuries, do not displace over time and hence do not require further clinic attendances and xrays after the first consultation. Beyond the first week, regular clinic reviews and serial xrays are not necessary in the treatment of Weber B ankle fractures. The presence of medial side tenderness was a poor indicator for joint instability in this series. with proper protocols in place, these can lead to a significant decrease in the workload of orthopaedics surgeons.


R Dalal E Mulgrew G Devarajan

Subtalar joint stiffness is an under recognized complication of ankle fractures. We set out to objectively measure its prevalence and impact on Activities of Daily Living (ADL).

Method:

60 ankle fractures included in study. All patients had contralateral normal ankle.

M:F=21:39

Average age: 36 (19 – 84)

Weber: A B C

21 27 12

27 patients underwent ORIF (12C + 15B)

39 patients had plaster casts for between 2 and 6 weeks. (27B + 12C)

Postop regimes included early mobilization and POP application (AO recommendation)

Weber A (21) treated symptomatically.

Examinations for study at 3/12 and 6/12 post injury.

Subtalar and ankle movements were assessed by the same examiner (as per Hoppenfeld)

Subjective questions about subtalar stiffness and their impact on ADL were asked.

Results:

At 3/12, 56 patients (17A + 27B + 12C) had subjective and clinical impairment of subtalar movement.

32 patients (2A + 20B + 10C) had moderate to severe impairment (> 30%)

At 6/12, 42 patients (9A + 23B + 10C) had subjective symptoms and clinical impairment of subtalar function. Of these, 26 (0A + 18B + 8C) had > 30% impairment vs. controls.

Conclusions: Symptomatic subtalar joint stiffness with limitation of ADL is a significant sequel of ankle fractures and results in long term morbidity. This has implications in assessing functional outcome of these common injuries.


D Osarumwense T Millar Y Feldman

The recognition, investigation and management of osteoid osteoma has been well documented. Treatment can either be medical or surgical, studies have shown both options to have almost equal long term outcomes. However only surgical treatment involving complete excision of the lesion allows for confirmatory tissue diagnosis of osteoid osteoma especially important in cases where symptoms and signs are atypical. Several methods of surgical treatment with varying degrees of success have been described in literature. Here we describe a surgical techniques for the treatment of osteoid osteoma which enables removal of the lesion in a precise manner using a precision bone graft trephine with minimal excision of bone. This technique will be very useful in the excision of lesions in areas in which excessive excision of bone can lead to an unstable bony structure which can predispose to fracture. To our knowledge this surgical technique in the management of osteoid osteoma has not been described in the literature.


R Dalal E Mulgrew K Lammin

We present our results with a modified Mann-Thompson procedure in 47 patients (86 feet). Minimum follow up was 24 months.

All patients had moderate to advanced forefoot deformities.

Methods:

M:F=12:35

43/47 bilateral

Simultaneous procedures in bilateral cases.

Popliteal block analgesia used routinely.

Technique:

Medial incision centered on MTP1 joint. Minimal bony and soft tissue resection. Fixation carried out with staples (78 feet),K-wires (8 feet)

Transverse incision centered on the lesser MTP joints made. Combination of soft tissue release, lesser MT head resection in cascade fashion from dorsal distal to proximal plantar performed. Lesser toe deformities treated by a combination of closed osteoclasis, soft tissue release and bony resection. Transarticular K-wire fixation then performed for all lesser toes.

Bulky postop dressing and post op shoes used.

Immediate FWB permitted.

Transarticular K-wires removed at 4/52.

Results:

AOFAS Forefoot Scores assessed at preop,6/12,12/ 12,and24/12.

Subjective patient assessment of procedure requested.

Average AOFAS scores improved from 37to72(67 – 84)

40 patients extremely pleased with the results. 5 patients pleased with reservations and 2 patients disappointed with the outcome.

Complications:

3 superficial wound infections

2 metal work related problems

2 early loss of lesser toe correction

3 late deformities of lesser metatarsals requiring surgery

Conclusion: This procedure offers excellent, reproducible biomechanical correction with high rates of patient satisfaction.


P Watmough N Roberts R Freeman J Lishman J Barrie

Primary care trusts (PCTs) are encouraged to create musculoskeletal services to improve access and reduce pressure on orthopaedic clinics. Previous reports have suggested problems can arise.

A PCT with a population of 100,000 launched a musculoskeletal service in July 2004. The foot and ankle component was in partnership with the local secondary care foot team. Treatment and referral guidelines were agreed. The PCT staff reviewed GP referrals to orthopaedic clinics. They could forward letters to the acute trust orthopaedic department or initially treat the patients in primary care.

We audited referrals from October-December 2004, allowing 3 months to establish the service and 6 months follow-up.

617 orthopaedic referrals were received, including 123 (19.9%) adult foot and ankle problems. 82 patients were treated initially in primary care: 54 by the podiatrist, 20 by the physiotherapist and 8 by the specialist GP. Commonest problems were metatarsalgia (12), hallux valgus (10), Achilles tendonopathy (9), plantar heel pain (9), generalised foot pain (8) and arthritis (6). The commonest intervention was attendance at a physiotherapy programme (26) followed by advice (22), usually about shoewear, insoles (14) and injections (8). Ten patients were referred to secondary care after initial treatment in the community, all in accordance with guidelines; four were listed for surgery. Four patients failed to attend and information was missing on six.

31 referrals were sent directly to secondary care, 29 of which were according to guidelines. 9 were offered surgery, 9 had other specialist care, 6 required services which could not be accessed directly by the PCT team and 3 failed to attend.

Primary and secondary care can work together successfully to deliver services for patients with foot and ankle problems, though waiting time remains a challenge.


G Shah R Dega

Arthrodesis of 1st MTP joint is a reliable procedure for hallux rigidus. We have studied the effects of first MTP joint arthrodesis on activities of daily living and leisure activities

Methods: We retrospectively evaluated 103 1st MTP fusion, done by a single orthopaedic surgeon with special interest in foot surgery over seven years period. All patient underwent two cross screw fixation for primary operation. Same operative technique was used in all patients.

We evaluated pre op scoring for pain, walking distance, walking up hill – stairs, foot wear, return to leisure activity and work, chronicity of symptoms, associated symptoms, radiological appearance pre op, post op and at radiological fusion and complication rate.

All patients were followed up.

The patients were contacted with questionnaire to evaluate the function after the fusion.

The patients were asked whether they would participate in the foot pressure study; which was done with the help of podiatrist at same trust.

We have tried to correlate the functional outcome and its relation to foot pressure.

Results: Fusion was achieved in all patients. (three after revision). Pain scores evaluated using the visual analogue scale, indicated effective pain relief. High levels of return to functions were noted. The pressure (under 1st or 2nd Metatarsal heads or laterally) study has revealed a pattern of changes with various symptoms.

Conclusion: Arthrodesis of first MTP joint, using two cross screws, is a successful surgical technique for Hallux rigidus and also allows high level of function in daily activities of living and leisure activities.


R Dalal E Mulgrew L Checkley

We present our results in 89 consecutive patients (138 feet), minimum FU of 24/12.

Methods: Typical indications were IM angles > 13 degrees, incongruent MTP1 joints.

Contraindications included abnormal DMMA, significant 1st MTP arthritis, hypermobility of 1st MTC joint, revision surgery.

All patients underwent a 3-in-1 procedure with soft tissue release in 1stwebspace, medial bunionectomy with capsulorraphy and basal crescentic osteotomy.

A 25 mm blade on oscillating driver was used. Fixation was staples(70%),screws(20%),K- wires(10%).

Post op, PWB, progressing to FWB at 3/52.

AOFAS forefoot scores at pre-op, 6/12, 12/12 and 24/12.

Weight bearing radiographs obtained at pre-op, 3/12, 12/12.

Results:

M:F=19:70

Age 31–79 (Mean 64)

89 patients, 138 feet

AOFAS scores improved from average 42/100 preop to 76/100 at 6/12.

Radiographic correction excellent in78% of patients.

74 % of patients extremely satisfied,15 %satisfied,11 %unsatisfied with outcome.

Complications:

Nonunion=2

Infection=2 superficial,1 deep

Recurrence of deformity at 6/12 = 2

12/12 = 2

Transfer metatarsalgia M2 due to overriding of distal M1=3

Conclusions: Basal Dome Osteotomy with soft tissue correction is powerful and reproducible for the correction of moderate and severe Hallux Valgus. There is an initial learning curve. Much less soft tissue dissection required compared to the SCARF procedure. Results are very satisfactory.


Purpose of the study: Titanium cases are used to achieve mechanical stable spinal reconstruction immediately after corpectomy. Bone grafts is often associated to ensure long-term success. Plain x-rays do not allow correct visualization of the graft within the cage, hindering evaluation of the fusion. The objectives of this study were to obtain a precise evaluation of the graft outcome within the cage using computed tomography (CT) and to search for factors affecting bone fusion.

Materials and methods: This was a retrospective analysis of a consecutive series of patients undergoing anterior reconstruction of the thoracolumbar spine with a titanium cage and a bone autograft. 3D CT reconstructions were obtained at least three months after reconstruction surgery. Three independent observers (two surgeons and a radiologist) analyzed the images. Standard CT criteria for graft fusion are not described in the literature for this type of arthrodesis so the criteria used were based on a descriptive analysis of the CT slices. A statistical analysis was then conducted to search for factors affecting fusion: epidemiological features, etiology, type of graft, size of the case, number of levels reconstructed, associated posterior arthrodesis. The regional angle was analyzed postoperatively and at last follow-up to determine how the sagittal correction was maintained.

Results: Twenty-eight cases were reviewed. Reconstructions had been performed for burst fractures, tumor resection, or deformed callus. CT analysis demonstrated three fusion zones to be examined: the upper, middle and lower part of the cases. Bony bridges were noted at the extremities in all cases. The middle part of the cage generally presented a heterogeneous image which was insufficient to confirm fusion. Loss of correction was not significant. No co-factors could be identified which influenced fusion.

Discussion and conclusion: Most of the cases reviewed did not present a continuous bony bridge from one end to the other of the cage yet the sagittal correction was satisfactory and persistent. The structure of the cages might be modified with a solid intermediary zone which could «spare» graft material.


Hector Malvarez

Purpose of the study: Increased cost of care and limited resources have become important factors in patient treatment. We wanted to ascertain the cost of hospital care, the duration of the hospital stay, the number of rest days, and the degree of correction achieved in a group of patients with idiopathic scoliosis treated surgically over a period of 40 years using four different surgical techniques: Hibbs, Harrington, Harri-Luque, and a multiple hook system.

Material and methods: This retrospective analysis included 50 patients treated in the same center (Scoliosis Center of the Buenos Aires Italian Hospital. Duration of hospitalization before surgery, total duration of the hospital stay, duration of rest, degree of correction, updated hospital cost and updated expenditures for implants and physician fees were noted.


Daniel LEPAGE Bernard PARRATTE Laurent TATU Fabrice VUILLIER Yves TROPET Guy MONNIER

Purpose of the study: Spastic hypertony of the upper limb produces pronation of the forearm with flexion of the wrist and fingers. Treatment is generally based on injections of botulinum toxin and sometimes on selective neurotomy.

Material and methods: In order to achieve better selection of the motor branches innervating the muscles requires a precise knowledge of the extramuscular innervation. Similarly, for botulinum toxin, injections must be made as close as possible to zones with the greatest density of intramuscular nerve endings, considered as the zones having the greatest number of neuromuscular junctions. Knowledge of these zones is currently insufficient. We therefore conducted a macroscopic then microscopic dissection of the muscles of the ventral forearm in 30 specimens to study extra- and intra-muscular innervations and the distributions of the nerve endings.

Results: Surface maps were drawn to describe the precise localization of the motor branches for each muscle. These maps were designed as guides for surgical approaches for selective neurotomy. Then for each muscle, the zones with the greatest density of nerve endings were delimited in segments which could be used to define optimal zones of injection of botulinum toxin.


Marc-Antoine ROUSSEAU Jean-Yves LAZENNEC Gérard SAILLANT

Purpose of the study: PEEK (polyetheretherketone)is increasingly used for spinal fusion since its elasticity modulus is close to that of cancellous bone. This favors harmonious force distribution within and around the implant and thus stimulates bone healing by remodeling. The purpose of this work was to report the mid-term radiographic outcome with this material used for sagittal correction.

Material and methods: Fifty-seven patients aged 54.6 years on average were reviewed 4 to 8 years after isolated intervertebral fusion for degenerative disease. Levels varied from L2L3 to L5S1. Posterior instrumentation used a rigid or semi-rigid pedicle screw-plate configuration associated with an anterior approach to install a lordozing intersomatic PEEK cage and a cancellous autograft. Six patients were overweight. Regional lordosis was unchanged postoperatively for 47 patients but increased 8.2° on average for ten. The clinical outcome and radiographic fusion were noted using the Brantigan classification. Multivariate analysis was used to search for correlation between regional sagittal correction at last follow-up and the following variables: age, body weight, level, quantity of intersomatic autograft as assessed by CT, rigidity of the posterior instrumentation, posterior regional correction and size of the cage.

Results: The clinical outcome was excellent for 24 patients, good for 25, fair for 6 and poor for 2. Mean sagittal correction was decreased in 13 (5.6° on average). Multivariate analysis demonstrated a significant correlation (p< 0.01, R2=0.590) between loss of correction and the following variables: degree of initial correction, rigidity of the posterior instrumentation, age, lower level, size of the cage.

Discussion and conclusion: Despite the excellent rate of fusion, sagittal correction of the regional lordosis did not persist over time and tended to return to the initial state irrespective of the patient’s weight or the quality of the initial graft. A rigid posterior instrumentation should be considered in parallel with the effect of the PEEK for explaining its role in the loss of correction.


Olivier DRAIN Raphaël VIALLE Ludovic RILLARDON Pierre GUIGUI

Purpose of the study: Experimentally, posterolateral fusion only allows incomplete control of flexion/extension, rotation and lateral inclination. This defect of posterolateral fusion is most marked with there is a wide anterior gap. For certain authors, this situation justifies use of intersomatic arthrodesis. The purpose of this work was to evaluate, within a spinal segment immobilized by posterolateral fusion, the changes observed in disc height and the possible clinical and radiographic impact of a change in disc height.

Material and methods: This was a retrospective analysis of a consecutive series of patients who underwent posterolateral fusion from January 1999 through December 2003 performed in addition to radicular release for degenerative spondylolisthesis were included. Functional symptoms were noted using: VAS, Beaujon function scale, Beaujon self-administered questionnaire, satisfaction scale, GHA28 anxiety/depression scale, and SF36 quality of life questionnaire. Spineview® was applied at the olisthesic level (disc height, listhesis, anglulation), at adjacent levels, for pelvic parameters, sagittal tilt, and vertebral motion on stress views. We searched for a correlation between the consequences of changes in these variables was and the functional outcome as well as the quality of the fusion. The effect of variations in the following preoperative variables was studied with multivariate analysis: disc height, intervetebral angulaion, listhesis, vertebral motion, sagittal balance, use of osteosynthesis or not.

Results: Forty patients were reviewed with a mean follow-up of 38 months (range 15–70 months). Decreased disc height at the olithesic level was associated with local kyphosis. The level above tended towards lordosis while the level below towards kyphosis. These variations had no effect on the final functional outcome.

Discussion: No formal argument could be found in the literature favoring the use of intersomatic arthrodesis to complete posterolateral fusion for the treatment of degenerative spondylisthesis. Disc height is lost after isolated posterolateral fusion with a risk of local kyphosis and persistent intervertebral motion, but these effects do not appear to influence the functional outcome nor the rate of fusion. More than disc height, it would appear that sagittal balance should be preserved to improve functional outcome.

Conclusion: This study enabled us to observe, as is reported in the literature, decreased disc height after posterolateral fusion for degenerative spondylolisthesis. However, there appears to be no correlation between this decreased disc height and the functional outcome. More than disc height, sagittal balance appears to be the determining factor.


Gustavo RAMIREZ

We present our four-year experience with a new minimally invasive method for ambulatory treatment of lumbar discal herniation: micro video endoscopic dissectomy.

Video endoscopic surgery associates microsurgical procedures similar to those used in conventional surgery with a very precise technique. This method was used for 50 patients presenting lumbar disc herniation diagnosed with magnetic resonance imaging using the MacNab criteria, placing priority on the neurological risk of sensorimotor deficit.

Clinical outcome was also evaluated with the MacNab criteria. These patients were able to walk early, resumed work rapidly, and had little lumbar pain and few complications.


Gustavo RAMIREZ Juan-Pablo BERNASCONI Pedro COLL Tomas RUDT

Exact knowledge of the site of the lesion, and a better understanding of the traumatic mechanisms have led to a major improvement in the surgical approach used for the treatment of thoracolumbar fractures.

The first reports of a combined anterior and posterior approach recommended a two-week recovery period between the two stages.

It was observed however that the rate of complications was higher and that at the time of the second stage patients had a poor nutritional status which increased the rate of mortality. It was also remarked however that a sequential approach performed on the same day could be achieved.

Recently, the simultaneous anterior and posterior approach was reported by Farcy and others. Their preliminary results indicate that in terms of duration of anesthesia, blood loss, and complications, the simultaneous method is better than the sequential method.

The purpose of our work was to report an analysis of the mechanical and biological benefits of the simultaneous approach for the treatment of thoracolumbar spinal fractures.


Luc BOSCA Charles COURT Thomas NODARIAN Véronique MOLINA Jacques-Yves NORDIN

Purpose of the study: This study was conducted to assess short- and mid-term radiographic outcome of percutaneous posterior osteosynthesis (Sextant®)of thoracolumbar spine fractures and to identify indications and complications.

Material and methods: The Sextant® material was used for 14 patients with a lumbar spine or low thoracic spine fracture. Mean patient age was 40 years (range 19–84). Outcome was reviewed retrospectively. Osteosynthesis was performed for 11 fractures Mager 1 A3, 2 B2, 1 C1 with no neurological deficit. A complementary graft and anterior decompression were used 11 times (9 fibular, 1 posterior crest + rib, 1 cage). The pre- and postoperative and 3 month ART were noted. The position of the implants was assessed on the postoperative CT.

Results: Mean follow-up was 9.2 months (range 2–16). On average, ostheosynthesis was performed 15 days after trauma (range 1–90 days). There were no neurological or infectious complications. Sutures had to be resected in two cases due to cutaneous suffering. Nine patients wore a corset for three months. The absolute ART score improved from 18 preoperatively to 7 postoperatively and was noted at 14 at three months. Seven patients required heterologous blood transfusion after the anterior approach. Three screws (5.3%) were ectopic but without consequence.

Discussion: Indications for percutaneous osteosynthesis include spinal fractures without neurological complications with sagittal deformation for which an anterior approach is planned initially for mechanical reasons. An isolated anterior approach is possible in this type of fracture; nevertheless, percutaneous posterior osteosynthesis enables emergency reduction and fixation of the fracture, a simplified secondary minimal anterior approach for release, and bone grafting without anterior instrumentation. Three patients did nor require complementary anterior stabilization as the percutaneous oseosynthesis played the role of «internal fixation». The advantages of percuteneous osteosynthesis are the absence of bleeding and damage to the paravertebral muscles which limits morbidity, particularly infection. This technique can be performed in the emergency setting, especially for multiple trauma victims. The drawbacks of percutaneous osteosynthesis are the impossibility of performing a posterior fusion and release the spinal canal. The loss of correction observed were probably related to the type of graft (fibular). Use of a cage should limit graft impaction and loss of correction.


Anthony WAJSFISZ Ludovic RILLARDON Raphaël JAMESON Olivier DRAIN Pierre GUIGUI

Purpose of the study: Conventional treatment for recurrent lumbar disc herniation is repeated discectomy. Other methods such as fusion, ligamentoplasty or implantation of a discal prosthesis are sometimes proposed but all increase morbidity. The purpose of this work was to ascertain the efficacy of isolated repeated radicular release for the treatment of recurrent discal herniation.

Material and methods: Thirty-four patients underwent surgery for recurrent discal herniation. Repeated radicular release was used in all patients included in this analysis who completed a self-administered questionnaire at last follow-up to assess the final functional outcome.

Results: The cohort included 13 women and 21 men, mean age at surgery 45 years. Mean time from first discectomy to revision surgery for recurrence was 55 months. At the time of the review, four patients had died, all four from cancer. None of these patients had undergone a revision procedure on the lumbar spine. One patient was lost to follow-up so 85% of the cohort was analyzed with 60 months average follow-up. A dural tear occurred during the proscedure in six patients (17%. Five patients (14.7%) required revision surgery, one for deep infection, four for recurrent or persistent lumboradiculalgia (recurrent discal herniation, isthmic fracture, lateral stenosis associated with inflammatory discopathy). The rate of revision for painful failure was 11.4%. The final outcome could be assessed for 25 patients and was satisfactory for 22/25 (88%). The self-administered questionnaire revealed 65% average improvement with more than half of the patients reported better than 80% improvement. Ten patients (40%) complained of lumbar pain and a third had residual, generally intermittent, radiculalgia. Eighteen of 25 patients resumed their work at a comparable level after six months on average; 84% of the patient would accept the same operation again.

Discussion: In terms of morbidity and rate of revision, the results are comparable to reports in the literature. Repeated release does not increase the risk of a new recurrence.

Conclusion: This work enabled us to demonstrate that in the large majority of patients repeated discectomy provides satisfactory functional outcome with little morbidity.


Xavier CHIFFOLOT Mohammed AOUI Ioan BOGORIN Patrick SIMON Jean-Michel COGNET Jean-Paul STEIB

Introduction: Surgical treatment of thoracolumbar spine fractures from T11 to L2 with correction of the traumatic kyphosis should be expected to avoid the deceptions observed with former treatments.

Material and methods: Seventy trauma victims (41 men and 29 women) underwent surgery between 1996 and 2003. According to the Denis classification, they presented: 16 compressions, 43 burst fractures, 8 seat belt fractures, and 3 disclocations. The Frankel classification was E:62, A:2, C2, D:2. Mean follow-up was 30.7 months. A pedicle screw protected with sublaminal hooks below and pediculotransverse claws above was used in 50 patients with a hybrid configuration in 20. Reduction was achieved by in situ cerclage. A secondary anterior graft was implanted for 38 patients.

Results: Patients were allowed to rise without contention on day 3. The traumatic angle measured with the sagittal index of Farcy (SIF) (the quality parameter used to study reduction) was 17 preoperatively and 1.6 after surgery. The loss at last follow-up was −2.2° with 81% of patients presenting normal or over correction. The loss was greatest (5.2°) for uniquely posterior approaches. The final Oswestry score was 29.8 (range 6–80) with a better result for the double approaches (20.7 versus 37.4, p< 0.001). Complications were phlebitis (n=1), sutured dural breaches (n=2), disassembly and nonunion (revision with a double approach) (n=1), infection (treated by wash-out and antibiotics) (n=10), retroperitoneal hematoma (treated by embolization) (n=1). Thirty-two patients resumed their work at seven months on average and 13 did not (25 without professional occupation).

Discussion: The overall results are better than those after orthopedic treatment. The rate of resumed work was 71%. This is an excellent result with a less aggressive treatment protocol (no corset) and shorter hospital stay (5–19 days). The protective hooks facilitate in situ cerclage, avoiding catching the screws and the risk of disassembly. The anterior graft is necessary when the reduction is discal and reduces the angle loss leading to less morbidity.

Conclusion: In situ cerclage enables constant sustained reduction of thoracolumbar fractures. Indication for surgery is often retained because of major deformation. Spinal fractures should be examined with the same assessment criteria as used for fractures of long bones and weight bearing should begin early to avoid the risks associated with prolonged bed rest.


Philippe MERLOZ Hervé VOUAILLAT Ahmad EID Christian VASILE Sorin BLENDEA Bernardo VARGAS-BARRETO Johan ROSSI Stéphane PLAWESKI

Purpose of the study: We describe a surgery navigation system based on virtual fluoroscopy images established with a 3D optic localizer. The purpose of this work was to check the accuracy of the system for posterior spinal implants in comparison with conventional surgery. Duration of radiation and duration of surgery were compared.

Material and methods: A 3D optic localizer was used to monitor the position of the instruments in the operative field, as well as the fluoroscopy receptor. The surgeon took two views, ap and lateral, with a total exposure of two seconds. The C arm was then removed. After image correction, the ap and lateral views were displayed on the work station screen where the computer superimposed to tools on each image. Twenty osteosynthesis procedures for implantation of pedicular screws via a posterior approach to the thoracolumbar spine were performed with this virtual fluoroscopy technique (20 patients, 68 screws). During the same study period, twenty other procedures were performed with the conventional technique (ap and lateral x-ray with the C-arm after drilling the pedicle, 20 patients, 72 screws). The position of the spinal implants was compared between the two series on the ap and lateral views and postoperative CT. Similarly time of exposure to x-rays and duration of the surgical procedure were recorded.

Results: The rate of strictly intrapedicular implantation was less than 8% (5/68 screws) in the virtual fluoroscopy series versus 15% (11/72 screws) in the conventional series. Time of exposure to radiation was significantly lower in the virtual fluoroscopy series with a 1 to 3 improvement (3.5 s versus 11.5 s on average) over the conventional method. With training, this method is not more time consuming (10 min per screw for the conventional method versus 11.25 min for virtual fluoroscopy).

Discussion and conclusion: Compared with conventional fluoroscopy, the virtual technique enables real time navigation while significantly reducing the dose of radiation, both for the patient and the surgery team. There are two types of advantages of virtual fluoroscopy over CT-based systems: first virtual fluoroscopy is immediately available without specific preoperative imaging and secondly it provides real non-magnified images acquired once during the procedure, after which the C-arm is removed. 3D virtual fluoroscopy is probably the next step but requires further experience.


Sami ZOUAOUI Nicolas NOISEAUX Jean-Albert OUELLET Rudy REINDL Vincent ARLET

Purpose of the study: We report the results of a series of seven cases of non-tuberculos infectious lumbar spondylodiscitis treated by posterior instrumentation and secondary anterior curettage of the infectious focus with bone grafting. This particular osteosynthesis method produces a short monosegmentary fixation limited to the space of the infected disc.

Material and methods: The series included six men and one woman (mean age 61.7 years, age range 37–82 years). The causal germ was identified in all cases: Staphylococcus aureus in five, and in one each, Staphylococcus epidermidis and Pseudomonas aeruginosa. Levels were L1L2 in one, L2L3 in two, L3L4 in three and L5S1 in one. Predisposing factors were history of prostatic cancer in two patients, coronary heart disease in one and chronic renal failure in one. One patient had received corticosteroid injections and two had no recognized co-morbid conditions. The surgical procedure was undertaken due to persistent pain in three patients (one with quadriceps amyotrophy and weakness), spinal instability with risk of neurological injury in two, and after failure of medical treatment in two patients who had persistent abscesses.

Results: Excepting one patient who died from renal failure four months after the surgical procedure, mean follow-up was 31.5 months (range six months to six years). Outcome was excellent in four patients, good in one, and a failure in one patient who was operated on because of instability. Failure of the instrumentation required surgical revision to extend the initial assembly. At last follow-up, all patients had achieved fusion of the instrumented zone and were considered to be cured of their infection.

Discussion: Classically, it is advisable to avoid instrumenting close to an infectious area in order to avoid the vicious circle of infection. Configurations described in the literature are usually extensive, blocking healthy levels beyond the infected area and compromising spinal mobility. However, a short instrumentation limited to one segment can be proposed when the end plates at the outer limits of the infectious focus are theoretically healthy. Careful analysis of the imaging data is required to carefully select patients who can benefit from this short configuration. Magnetic resonance imaging is most helpful.


Bernardo VARGAS-BARRETO Sophie BESSAGUET Aurélien COURVOISIER Ahmad EID Philippe MERLOZ Fréderique NUGUES Cécile ALVAREZ Chantal DURAND

Purpose of the study: Prenatal screening and search for risk factors has lead to early diagnosis of congenital hip dysplasia. The percent of excentration of the dysplastic hip can be quantified with ultrasonography. The purpose of this study was to evaluate the usefulness of ultrasound monitoring of confirmed hip dysplasia as a method for determining the appropriate time to discontinue treatment.

Material and methods: We collected a series of patients presenting unstable hips one month after birth. Ultrasonographic examinations were performed to quantify the instability. Initial treatment was forced abduction. If the infant’s weight was greater than 5.6 kg, a Pavlik harness was used. Physical examination and control ultrasound examinations were performed at 4, 8 and 12 weeks. Forced abduction and ultrasound surveillance were discontinued when the percent of acetabular cover was greater than 50%. Long-term surveillance consisted in physical examination and plain ap view of the pelvis at four months and at onset of walking.

Results: Ultrasound monitoring was instituted for 71 hips in 51 patients. Mean age at onset of the monitoring scheme was 37.7 days (range 38–74 days). Mean acetabular cover, as evaluated by ultrasound before treatment, was 35.5% (range 20–45%). After four weeks, mean cover for 42 hips was 54.7% (range 50–85%). For the other 29 hips, mean acetabular cover was 41.4% (range 36–47%) at four weeks. At eight weeks, 26 of these 29 hips had a mean cover of 60% (52–85%). Acetabular cover remained below 50% for three hips at twelve weeks. Mean HTE at four months was 20.7° (range 10–26°). At walking, all hips were centered and no irregularities were noted on the x-rays of the femoral nucleus.

Discussion: The majority of infants with unstable hips diagnosed at birth achieve spontaneous cure without treatment. For others, cure can be achieved with forced abduction but with a risk of osteochondritis. In our study, ultrasound monitoring enabled a reliable assessment of the proper moment to interrupt treatment.

Conclusion: Ultrasound examination of the hip joint is a satisfactory method for monitoring hip dysplasia in infants aged less than four months. It appears to be useful for determining the moment to interrupt treatment.


Frédéric SALMERON Jean-Marc LAVILLE Ami TERKI

Purpose of the study: the Pavlik harness has been used for the treatment of congenital hip dislocation since it was designed by Arnold Pavlik in 1950. There remains however a certain debate concerning the best moment to start treatment and its duration. We advocate early use of the Pavlic harness for a short period.

Material and methods: Forty-five hips (34 infants) were treated. The diagnosis of dislocation was clinical. The Barlow and Ortolani maneuvers were used to search for clinical instability classed as «positive dislocation test» or «negative test but presence of piston movement». Different classifications of positive tests were used to search for an association with increasing severity of hip instability. Static and dynamic ultrasound was then used to confirm the diagnosis of hip dislocation. A Pavlik harness was installed immediately after diagnosis of congenital hip dislocation, on the day of birth if possible, according to the precepts proposed by the inventor.

Results: Among the 43 hips analyzed I the present series, reduction and stabilization was successfully achieved with the Pavlic harness in 40 used as early as possible for a short a period as possible. This 95.6% success rate (2 failures, 0 complications) was achieved within 3 o 8 weeks.

Discussion: Our results are comparable with other series reporting early use of the Mubarak method. The duration of treatment was shorter with our therapeutic method. We did not attempt to treat the dysplasia, spontaneous regression was monitored radiographically.

Conclusion: We consider congenital hip displasia to be a therapeutic emergency. Treatment should be undertaken as soon as the dislocating intrauterine constraints cease. Early use of the Pavlik harness on easily dislocated or dislocated reducible hips has given excellent results. The shorter treatment duration does not lead to any recurrence as long as clinical stability with formal radiographic confirmation at treatment end.


Pierre JOURNEAU Laurence MAINARD Thierry HAUMONT Olivier TOUCHARD Gilles DAUTEL Pierre LASCOMBES

Purpose of the study: It is relatively rare to observe villonodular synovitis in children. The predominant localization is in the large joints. Histology is required for definitive diagnosis but specific sequences of magnetic resonance imaging (MRI) has greatly improved diagnostic performance.

Material ad methods: we report four cases of hemopigmented villonodular synovitis observed in four girls aged 11–16 years (mean age 12 years) at diagnosis. Localizations were the knee joint in two, the metacarpophalangeal joint of the third finger in one and an intracarpal joint with scaphoid defects in the fourth. Plain x-rays centered on the joint involved and MRI spin echo T1 and T2 with fat saturation were obtained for all four children. Echo gradient with long TE sequences were also performed for the last two children because of the anomalies observed in the first two.

Results: The MRI findings enabled the diagnosis of hemopigmented villonocular synovitis in all four patients and was confirmed histologically (two biopsy specimens followed by dissection and two first-intention dissection specimens).

Discussion: The large joint localizations are often reported but the two cases involving the wrist and fingers are less common. The condition is usually revealed by repeated joint effusion which if punctured generally reveals a hematic discharge. Pain is classical and a mass is often palpated. Standard x-rays show intraosseous defects and MRI, using the three sequences together, generally provides the diagnosis. On the spin echo T1 sequence the synovial mass gives an intermediate signal compared with the low intensity signal of the joint fluid since the cholesterol deposits enhance the signal. In spin echo T2 sequence with fat saturation, the lesion produces a heterogeneous signal which is still intermediary because of the hemosiderin and cholesterol deposits which decrease the inflammatory aspect of the synovitis. These signs are highly suggestive and should be followed by an echo gradient long TE sequence. This is not a routine sequence but provides objective evidence of hyposignals within the synovial mass. This type of signal is specific for the presence of iron and thus hemosiderin.

Conclusion: MRI is the exploration of choice for the diagnosis of hemopigmented villonodular synovitis. It enables postoperative monitoring in search of recurrence.


Federico CANAVESE Alain DIMEGLIO

Purpose of the study: The appropriate treatment for Legg-Perthes-Calvé disease (LPCd) remains a subject of debate. Certain teams consider orthopedic treatment adequate. Others advocate surgery to improve prognosis. Is surgery necessary? When is the proper time? We reviewed retrospectively 91 surgically treated hips (Salter osteotomy or triple pelvis osteotomy) at the end of growth.

Material and methods: Among 485 hips with LPCd, 349 (71.9%) presented massive involvement (Catterall 3 and 4, Herring B and C, Salter B). Ninety-one patients with severe disease were reviewed at the end of growth. Complementary explorations included magnetic resonance imaging, scintigraphy and arteriography using the Dias protocol which enables an assessment of the excentration and the femoral head deformation and identifies hips at risk. Surgical treatments were Salter osteotomy (SA) or triple osteotomy (TO). Three groups were identified depending on the age at disease diagnosis: less than 5 years, 5–9 years, more than 9 years. Using the Stulberg and Mose classifications, outcome was considered good (Stulberg 1 and 2, Mose good), fair (Stulberg 3, Mose fair), or poor (Stulberg 4 and 5, Mose poor).

Results: There were 50 Carttell 3, Herring B, Salter B hips and 41 Catterall 4, Herring B and C, Salter B hips (80% boys). Distribution by group of age at diagnosis was: 34 (37.4%) less than 5 years, 48 (52.7%) 6–9 years, 9 (9.9%) more than 9 years. Salter osteotomy was performed on 32 hips (35.2%) and triple pelvic osteotomy on 59 (94.8%). Outcome at end of growth was: less than 5 years Catterall 3: 77% good, 15.4% fair, 7.6% poor; Catterall 4: 52.4% good, 33.3% fair, 14.3% poor; 6–9 years: Catterall 3: 70% good, 20% fair, 10% poor; Catterall 4: 55.5% good, 22.2% fair, 22.2% poor; more than 9 years: Catterall 3: 42.9% good, 42.9% fair, 14.2% poor; Catterall 4: 50% good, 50% poor.

Conclusion: Outcome worsens with increasing age at diagnosis. Despite surgery, a spherical femoral head (Stulberg 1 or 2) is achieved in only one hip Catterall 4 hip out of two. This result is observed in Catterall 3 hips only in children whose diagnosis is established after the age of nine years. Prognosis is better in Catterall 3 hips.


Alain DIMEGLIO Federico CANAVESE

Purpose of the study: Special care is warranted only for severe forms of Legg-Perthes-Calvé disease (LPCd) (Catterall 4, Herring B and C, Salter B, involvement > 50%). Should we propose specific treatment or simply monitor the inevitable disease course?

Material and method: Among a series of 485 hips with LPCd, 148 (30.5%) with massive involvement were identified. Ninety-six (64.9%)severe forms were analyzed at the end of growth. Magnetic resonance imaging, scintigraphy and arteriography were used to better assess the femoral head and identify hips at risk. These hips were treated surgically: Salter osteotomy (SA), triple pelvis osteotomy (TO), or varus osteotomy (VA). Three groups of infants were identified according to age at diagnosis of LPCd: less than 6 years, 6–9 years, more than 9 years. Outcome was considered good (Stulberg 1 and 2, Mose good), fair (Stulberg 3, Mose fair), or poor (Stulberg 4 and 5, Mose poor).

Results: There were 54 hips (56.3%) in the less than 6 years group, 26 (27.1%) in the 6–9 years groups, and 16 (16.6%) in the greater than 9 years group. Outcome was good for 45 hips (46.9%), fair for 22 (22.9%) and poor for 29 (31.2%) hips and was independent of age at onset of treatment. In the less than 6 years group, 54 hips (56.3%) were Catterall 4, Herring B or C, Salter B. Among the 24 Catterall 4 hips (44.4%) treated orthopedically, outcome was good for 15 (62.5%), fair for 7 (29.2%) and poor for 2 (8.3%). Among the 30 Cartell 4 hips treated surgically, outcome was good for 16 (53.3%), fair for 9 (30%) and poor for 5 (16.7%). In the 6–9 year group, 26 hips (27.1%) were Catterall 4, Herring B or C, Salter B. Among the 10 Catteral 4 hips treated orthopedically (38.5%), outcome was good for 3 (30%), fair for 2 (20%) and poor for 5 (50%). For the 16 Catterall 4 hips treated surgically, outcome was good for 8 (50%), fair for 2 (12.5%) and poor for 6 (37.5%). In the greater than 9 years group, there were 16 (16.6%) Catterall 4, Herring B or C, Salter B hips. Among the 10 Catterall 4 hips treated orthopedically, outcome was good for 1 (10%), fair for 2 (20%) and poor for 7 (70%). Among the 6 Catterall hips treated surgically, outcome was good for 2 (33.3%), fair for 0 and poor for 4 (66.7%).

Conclusion: Good outcome decreases with age. Surgery increases the rate of good outcome in all age groups, but before the age of six years, there is no significant difference between orthopedic and surgical treatment. Before six years, spherical heads (Stulberg 1 and 2) were achieved in six out of ten hips in the 6–9 year group and in only two of ten in the group aged over 9 years.


André GAY Régis LEGRÉ Jean-Luc JOUVE Yann GLARD Franck LAUNAY Gérard BOLLINI

Purpose of the study: Assessment of limb reconstruction results using vascularized fibular grafts after bony resection for malignant tumors in children.

Material and methods: Thirty children (9 girls and 21 boys)underwent surgery between 1993 and 2000. Mean age was 11 years. Tumor localizations were: femur (n=17), tibia (n=6), humerus (n=5), radius (n=1) and distal ulna (n=1). Mean length of bone resection was 16 cm (range 10–26 cm). For 22 children, the adjacent epiphysis was preserved. For the eight others, fusion was also performed. Two surgical teams operated sequentially: the first team performed the tumor resection and the second (an orthopedist for the osteosynthesis and a plastician for the vascularized fibular transfer) the limb reconstruction. Radiographic and clinical assessment was completed with bone scintigraphy. The index of graft hypertrophy was determined with the De Boer and Wood method. Functional outcome was assessed with Enneking criteria.

Results: Mean follow-up was 51 months (range 2 – 9 years). Early amputation was necessary for two children due to local oncological complications. One patient died of pulmonary metastasis eight months after limb reconstruction. Among the 27 other patients, primary healing was achieved in 22. In the five with primary nonunion, bone scintigraphy showed objective signs of a lack of blood supply to the graft. Secondary union was achieved with a complementary autologous bone graft in four cases. All cases of stress fracture healed with orthopedic treatment. For the 22 patients with primary union, the graft hypetrophy was 22–190% (mean 61%). For the five patients without bone vascularization on the scintigraphy, the fibular graft failed to hypertrophy. Functional outcome was satisfactory. The modified Enneking score (30 point scale) was 26 (range 19–30 points).

Discussion: Limb reconstruction results are directly related to good patency of vascular anastomoses. Postoperative bone scintigraphy is useful to determine blood supply to the graft and to establish the final prognosis. In the case of vascular failure, an autologous bone graft can be proposed early to enable union. Close collaboration between the plastic surgery and the orthopedic team is the key to successful limb reconstruction with a vascularized fibular graft.


Michel SEMPÉ Jérôme BÉRARD Franck CHOTEL Thierry CRAVIARI

Purpose of the study: Determining bone age at the wrist is not an easy task and can be a source of error. We elaborated a method for determining bone age at the elbow using an analysis of bone maturation at this localization.

Material and methods: The method finetunes the Sauvegrain method and is based on more than ten years of data for the analysis of more than 3600 x-rays. Bone maturation evolves from 0% at birth to 100% marking the end of growth. We propose a digital system for drawing the growth curve from 50% to 100% bone maturation as a function of chronological age. This curve gives the distribution of bone age around the median for each gender. Fifty percent maturation corresponds to onset of adolescence and can be used to define onset of puberty before any other clinical sign; 100% bone maturation corresponds to maximal growth or stature. Specific bone landmarks are used and the method for calculating bone age is presented.

Results: It is interesting that a shift of one year or more between bone age calculated at the elbow and that calculated from the wrist. This observation was frequent and suggests that bone age determined at the elbow gives a better reflection of limb maturation. In addition, regular use of this method in daily practice confirmed its usefulness, reliability, and inter- and intra-observer reproducibility.

Conclusion: This is a reliable simple method for determining bone maturation. It is easier to use than the wrist method and probably better reflects bone maturation of the limbs.


Bernardo VARGAS-BARRETO Ahmad EID Philippe MERLOZ Jérôme TONETTI Stéphane PLAWESKI

Purpose of the study: Appropriate treatment of displaced supracondylar fractures of the distal humerus in children remains a controversial topic. Blount reduction followed by percutaneous or open pin fixation have been widely used. The purpose of this study was to analyze outcome after open surgical treatment of these fractures in pediatric trauma victims.

Material and methods: The study included all pediatric patients who underwent surgical treatment for displaced supracondylar fractures of the distal humerus over a ten year period. Fractures were classified III or IV according to Lagrange and Rigault. Cross pinning was used in all cases, via a posterior approach or a double lateral and medial approach. The mechanism of the fracture and pre- and postoperative vascular and neurological complications were noted. The long-term assessment included standard x-rays of the elbow joint (ap and lateral views) and a physical examination to search for misalignment and residual neurological disorders.

Results: We identified 110 patients, 61 boys and 49 girls, mean age 7.61 years (range 2–15 years). There were 96 grade IV fractures and 24 grade III. Mechanisms were: sports accident (n=44), fall from height (n=36), fall from own height (n=30). A neurological complication was observed in 29 children, skin opening in three and regressive vascular damage in six. A posterior approach was used for 95 patients and a double approach for 15. There was one revision for secondary displacement. Five patients developed transient paresthesia of the ulnar nerve which resolved without sequela. Three patients presented a moderately hypertrophic or deformed callus which had little functional impact. One patient with an open fracture required surgerical arthrolysis for stiffness six months after fracture.

Discussion and conclusion: Open surgery is a very reliable treatment for supracondylar elbow fractures with a low rate of short- and long-term complications. Ulnar nerve palsy, the classical complication of percutaneous cross pinning, can be attributed to the medial pin (7–16% of cases in the literature). The Blount method and Judet or Métaizeau fixations can sometimes be complicated by secondary displacement or a deformed callus, complications which were almost never observed in our series. The results obtained in this series favor our approach for open surgery for the treatment of displaced supracondylar fractures of the distal humerus in children.


Mourad CHAKER Christophe GARIN Bruno DOHIN Rémi KOHLER

Purpose of the study: There remains some debate on the proper treatment of congenital dislocation of the patella in children and adolescents. Ligament-periosteum transfer (green-stick method) is a technique adapted for pediatric patients which realigns the distal extensor system.

Material and methods: Between 1979 and 2000, 36 children (51 knees) were treated with this method described by Grammont. Section of the lateral wing and medial capsulomyoplasty were associated in all procedures. Other complementary procedures used as needed included lengthening of the quadriceps, trochleoplasty, and quadriceps release. Mean age at surgery was 11 years (range 5–15 years). All patients were reviewed at bone maturity with a mean follow-up of 7.5 years for functional (IKC criteria) and radiographic assessment. A computed tomography and/or magnetic resonance imaging was obtained preoperatively and at last follow-up to assess TAGT, patellar height, trochlear angle, femoral anteversion, external tibial torsion, and knee rotation. Tibial slope was specifically studied to assess the possible epiphysiodesis effect.

Results: Two groups of patients were distinguished: congenital dislocation of the patella (persistent or usual) and objective patellar instability. Functional outcome was good in 74% and 87% of the knees. There were eight cases of recurrent dislocation: five knees were operated on with good outcome. The trochlear angle was improved in both groups, more significantly in the congenital dislocation group. There was one case of an inverted tibial slope (−2°) and two cases of cancelled slope.

Discussion: Our functional results are in agreement with earlier reports (Grammont, Bensahel, Langeskiold) but comparison is hindered by the heterogeneous nature of the different cohorts. Radiographically, we observed that trochlear remodeling, a sign of good stability, is better if the operation is performed early (before the age of ten years). On the contrary, in adolescents with major patellar instability, complementary trocheloplasty should be performed in addition to the recentering procedure. We observed that a small tibial slope became smaller in eleven knees in comparison with the nonoperated knee and in comparison with the preoperative slope for the bilateral cases. There appears to be a discrete epiphysiodesis effect but with no functional consequence.

Conclusion: We propose a classification of congenital dislocation of the patella in children. The ligament-periosteum transfer technique, associated with other procedures as needed, enables stabilizing the extensor system and a normal trochlear angle if surgery is performed at a young age. Remodeling of the tibial tubercle may result from transient disruption of the vascular supply.


Arielle SALON Fabien WALLACH Stéphanie PANNIER Jean LANGLAIS Pierre JOURNEAU Christophe GLORION

Purpose of the study: Even more so than adults, children are exposed to serious foot trauma caused by lawn mowers, bicycle spokes, or car wheels. These different mechanisms produce specific lesions to the rear foot or the toes and the dorsal aspect of the foot. Each type of lesion raises specific problems concerning emergency cover. Sequelae evolve with growth. We present a series of thirteen children given emergency treatment then long-term care over periods of six months to twenty years.

Material and results: The heel was amputated in four children (lawn mower or bicycle spoke accidents). Cover was obtained with a sural (three first-intention) neurovascular island flap with a distal pedicle. The long-term assessment evaluated function as well as residual growth of the calcaneum. Four lawn mower accidents produced lesions involving the toes and the mediotarsal area which did not require emergency flap cover. Dorsal retractions occurred in all four cases and progressed secondarily, later requiring a good quality skin flap and dorsal release. In five children lesions of the toes, forefoot, or the entire foot occurred in five children whose foot was crushed under car (or truck) wheels or was injured during fall from a wall. In these children, the urgent or secondary skin problems predominated in the dorsal area and required a variety of flaps.

Discussion: «Dorsal trauma» appears to have a predominant effect in children because the toe alignment during growth is directly dependent on the flexibility of the dorsal tissues. Several flaps can be used for this indication but are often difficult to achieve for the more distal areas (commissures and toes). Heel reconstruction is also a difficult challenge with the problem of sensitivity and tissue quality. It does not resolve the problem raised by amputation of the posterior calcaneal growth nucleus.


Pierre JOURNEAU Thierry HAUMONT Jean-Damien MÉTAIZEAU Pierre LASCOMBES

Purpose of the study: Joint puncture-wash-out is generally recommended for septic arthritis in children, but the debate is still open concerning the proper attitude for the hip joint. The purpose of this work was to examine our failure cases after treatment of septic hip arthritis using the puncture-wash-out option. We wanted to know whether first-intention primary arthrotomy might be a valid option.

Material and methods: We reviewed retrospective 29 cases of septic hip arthritis treated initially by puncture-wash-out between January 1996 and June 2003. We excluded all cases of first intention arthrotomy. The series included 19 boys and ten girls aged four years three months on average at time of diagnosis (age range 8 months to 9 years). Mean follow-up was one year five months (range 1 month the 4 years). Mean delay to diagnosis was two days (range 0–6 days). In addition to intravenous antibiotics, the 29 hips were drained and washed out with saline solution under general anesthesia until a clear wash-out was obtained. Surgical revision (arthrotomy) was required for seven patients within 3 to 21 days.

Results: Outcome was assessed at days 2, 5, and 10. Assessment variables were pain relief, normal blood tests, and apyrexia. Seven children required surgical revision for arthrotomy due to persistent clinical or biological disorders. Cure was achieved after all seven arthrotomies. At last follow-up, there was no difference, clinically or radiographically, between the children treated by puncture-wash-out or by arthrotomy. The factors which appeared to be the most significant to distinguish the two groups were, at admission: time to diagnosis and management greater than four days and C-reactive protein > 100. On day 5, the most significant factors were persistent joint pain and C-reactive protein > 100.

Discussion: These results suggest that puncture-wash-out remains a simple and reliable treatment but that it has its limitations: a synovial biopsy cannot be obtained, visual examination of the joint cartilage is not possible, trepanation of the metaphysis is not possible. Our factors favoring poorer outcome are similar to those reported in the literature to which can be added age less than one year. When these factors are present, first-intention arthrotomy should be discussed.


Didier MOUKOKO Paul-André DAUSSIN Alain DIMÉGLIO

Purpose of the study: The sub-fibular bone occurs as an ossicle adjacent to the apex of the lateral malleolus. Observed in 2% of children, it is generally a fortuitous x-ray discovery considered as a normal variant. Its rather high frequency in victims of former ankle trauma suggests the hypothesis of a traumatic origin. We have observed a high frequency of subfibular bone associated with functional ankle instability after trauma in children. The purpose of this study was to evaluate the function outcome after inverted ankle trauma in children with an avulsion fracture of the distal point of the lateral malleolus or a subfibular bone. We tested the hypothesis that presence of a subfibular bone corresponds to a sequelae of a former trauma and that it could led to a high frequency of mid- and long-term ankle stability.

Material and methods: This series included 50 children with a diagnosis of subfibular bone identified after trauma with ankle inversion. At least six months after the trauma, stability measurements were made to quantify residual functional instability of the ankle. Clinical signs of subjective instability were noted. A standardized protocol for stress x-rays was performed using the trauma-free contralateral ankle as the control.

Results: In more than 50% of patients, presence of a subfibular bone was associated with clinical signs of functional instability one year after ankle trauma. The quantitative measures of joint stability confirmed the significant presence of this instability, rarely associated with residual ligament laxity.

Discussion: In our series, most of the subfibular bones were interpreted as fracture-avulsions of the point of the lateral malleolus.

Conclusion: Discovery of a subfibular bone after an ankle «sprain» in children is a significant risk factor for subjective sequelar ankle instability after orthopedic treatment with a plaster cast.


Todor SOKOLOV Fabrice DELÉPINE Emile GUIKOV Gérard DELÉPINE

Purpose of the study: Prognosis is generally considered poor for patients with an iliac bone localization of Ewing sarcoma because the deep tumor is often large with initial metastases. This study demonstrates that the predictive value of these factors is related to treatment and that early en bloc resection can modify the prognosis.

Material and method: We have treated 62 cases of Ewing tumor of the iliac bone since 1976, 36 males and 25 females, mean age 16.5 years (range 4 – 47). Thirteen patients presented primary metastases. Mean tumor size, measured by digital imaging, was 729 cm3. Adapted chemotherapy was given in all cases. Local treatment included exclusive radiotherapy in 20 patients, radiochemotherapy in 15 and exclusive en bloc extratumoral resection in 27.

Results: At 15 years mean follow-up, overall relapse-free survival at ten years was 38%. This rate was 43% among patients without metastasis and 18% for those with initial metastasis (the three other patients underwent surgical resection of a primary focus and a bone metastasis). For patients with localized disease, prognosis was essentially determined by type and timing of local treatment. Surgical resection did not appear to have a significant effect on prognosis for patients operated on after three months; for these patients, only those with total histological response survived. Conversely, patient who underwent surgery before three months with en bloc resection and chemotherapy with at least five drugs had a relapse-free survival of 80% at ten years.

Conclusion: The prognosis of Ewing sarcoma is seriously dependent on the therapeutic modality, even when the localization is known to have a poor prognosis such as the iliac bone. Early en bloc extratumoral resection (before three months) greatly improved the prognosis of patients without metastasis, even for those with a very large tumor. Conversely, prognosis remained very poor for patients given exclusive radiotherapy or operated on late.


Eric MASCARD Philippe WICART Odile OBERLIN Jean DUBOUSSET Christian CARRIE

Purpose of the study: We wanted to assess long-term outcome after treatment for Ewing tumor of the pelvis.

Material and method: We reviewed 62 patients aged 5 to 28 years treated from 1983 through 1993. There were 35 males and 27 males. Sixteen patients had pulmonary metastases at diagnosis. Patients were given chemotherapy using three protocols (Ew 84, Ew 88, Ew 93) proposed by the French Society of Pediatric Oncology. Fourteen patients were give high-dose chemotherapy with a bone marrow graft. The local treatment was not randomized. Radiotherapy was used alone in 25 patients and 15 underwent surgery and radiotherapy. Eighteen underwent surgery without complementary radiotherapy. For patients were not given local treatment. Outcome at last follow-up was assessed retrospectively.

Results: Mean follow-up was 6.6 years (3 months to 18 years); 29 patients were in remission, 6 had progressive disease, and 27 had died. Two patients who had bone marrow grafts developed a second tumor in the radiated territory. The overall chances of survival were 55±6% at five years and 53±7% at ten years. There was no significant difference by type of chemotherapy. In the group of operated patients, the five year survival was 68% versus 43% in the group of non-operated patients (p=0.007). In patients with initial metastases, chances of survival at ten years were 19.7±10% versus 65.9±7% in patients without metastasis. Only two patients who presented metastases initially were in remission at last follow-up. Five patients developed local recurrence after surgery and none had been radiated despite incomplete response to chemotherapy or presence of contaminated resections.

Discussion: Rigorous comparison between operated and non-operated patients is hindered due to the different indications. Results of treatment of Ewing tumors of the pelvis without metastasis are comparable to those obtained for tumors in other localizations. The fact that a second tumor can develop in the radiated territory is a particularly important factor in patients given high-dose chemotherapy with a bone marrow graft.

Conclusion: Surgical treatment appears to improve local control of Ewing tumors of the pelvis. If initial metastasis is not present, the prognosis appears to be similar to other localizations. Radiotherapy remains and indispensable adjuvant in the event of surgical resection or incomplete response to chemotherapy.


Fabrice FIORENZA Josh BRAMER Robert GRIMER Simon CARTER Roger TILLMAN Seggy ABUDU

Purpose of the study: To analyze survival and prognostic factors in a series of patients treated for chondrosarcoma of the pelvis.

Material and methods: The series included 106 patients (53 women and 53 men) treated for non-metastatic chondrosarcoma of the pelvis. Minimum follow-up was two years. Mean age at diagnosis was 44 years. Tumors were grade 1 (n=47), grade 2 (n=37), grade 3 (n=22). Conservative surgery was performed in 73 patients (resection with or without reconstruction) and interilio-abdominal disarticulation for 33.

Results: Resection margins were sufficient for 34 patients (wide or radical resection), marginal for 35, and intratumoral or malignant for 37. Local recurrence was noted in 39 patients (37%). Prognostic factors affecting local recurrence were: quality of resection (p=0.03), grade (p=0.01). Overall survival at 5, 10 and 15 years were 72, 56, and 46% respectively. Survival was strongly correlated with grade (p=0.08) and survival after five years was also correlated with resection margins.

Conclusions: In this series, tumor grade was the most important prognostic factor for patients with chondrosarcoma of the pelvis but achieving satisfactory resection with wide margins also has a significant effect on prognosis for local recurrence and long-term survival.


François GOUIN Françoise RÉDINI Dominique HEYMANN

Purpose of the study: Wide en bloc surgical resection is the treatment of choice for cure of chondrosarcoma. Despite local control of this primary bone tumor in 60–80% of patients, mortality remains high. Recent studies suggest that biphosphonates can provide promising perspectives for the treatment of malignant bone tumors, even for primary tumors such as osteosarcoma. We report here the results obtained when using zoledronate for Swarm chondrosarcoma in an in vivo rat model and the effect of this compound on tumor cells in vitro.

Material and methods: Swarm chondrosarcoma was implanted in three series of 12 male Sprague Dawley rats. In series A, the animals were treated after implantation to death or sacrifice. In series B and C, the animals were treated a few days before curettage-resection then to death or sacrifice. Tumor growth was assessed by tumor size, presence of metastasis and death. Control series with PBS injections were also studied.

Results: Treatment with zoledronate inhibited tumor growth in all series. In series A, tumor size was significantly smaller in the treated animals (p=0.046). Tumor progression from day 19 to day 32 was significantly less for treated animals (p=0.046). Chance of survival was 0.667 for treated animals versus 0.3 for the controls. For series B and C, recurrence developed later in animals given zoledronate. Tumor size was greater in control animals compared with treated animals (p=0.043). Tumor progression from day 39 to day 49 was significantly greater in the control group (p=0.025). Cultures of cells extracted from the Swarm chondrosarcoma tumor also showed significantly inhibited growth in vitro for concentrations of zoledronic acid from 10 to 100 ml/l.

Discussion and conclusion: Zoledronic acid appears to inhibit growth of Swarm chondrosarcoma in all in vivo therapeutic schemas studied, confirming in vitro data. A more precise animal model better fitting clinical situations should provide more detailed information for use of this treatment after recurrence or in the event of intralesional surgery.


Gérard DELÉPINE Hélène CORNILLE Barbara MARKOWSKA Azzedine TABBI Nicole DELÉPINE

Purpose of the study: Nearly all published series of Ewing sarcoma present the present of bone metastasis as a factor of very poor prognosis. Reviewing our experience, we noted that the prognosis is not as bad as expected in these patients if surgical resection of all known foci can be achieved.

Case reports: Case n° 1 was a 16-year-old girl who presented a Ewing sarcoma involving the left iliopubic ramus. No other foci could be identified on the plain x-rays, scintigraphy and bone computed tomography. Preopeartive magnetic resonance imaging revealed a metastatic focus in the neck of the homolateral femur. The two foci were resected after preoperative chemotherapy: resection of the left hemi-pelvis and resection of the upper potion of the femur with replacement with a pelvic prosthesis and and massive prosthesis for the proximal femur. Eight years later, the patient has remained in complete primary remission, consulting for orthopedic gait problems related to prosthetic loosening. Case n° 2 was a 13-year-old boy who presented an Ewing sarcoma of the upper tibial metaphysic. Preoperative magnetic resonance imaging revealed three other metastatic localizations in the homolateral femur. Bifocal resection of the tibia and the femur was performed with implantation of an active growth prosthesis. Chemotherapy was continued. Seven years later, the patient remains in primary complete remission. Lengthening the prosthesis has enabled equivalent growth for the two limbs. The patient has a normal life style excepting contact sports which are prohibited. Case n° 3 was a 17-year-old boy who presented a voluminous Ewing sarcoma of the right pelvis. Search for extension revealed a unique metastasis in the fourth lumbar vertebra. The patient was given preoperative chemotherapy before resection of the pelvic tumor then two months later resection of the vertebral metastasis. The patient died 4.5 years later from a traffic accident. He had remained in complete remission.

Discussion and conclusion: These three cases of complete long-term primary remission of patients with primary bone metastases show that like other bone sarcomas, eradication of all recognized bone metastases is essential for the prognosis of Ewing sarcoma.


Miguel AYERZA Luis APONTE-TINAO Luis MUSCOLO

Purpose of the study: The purpose of this study was to compare two reconstruction procedures in terms of efficacy for tumor eradiation, reconstruction complications, and potential joint consequences.

Material and methods: This retrospective study included 43 patients with a giant-cell tumor located in the knee. Patients were treated by curettage combined with phenolization. Mean follow-up was seven years. Bone defects were filled with cement in 22 patients and with a fragmented allograft in 21. The reconstruction and potential joint degradation were assessed on standard x-rays obtained in the two groups.

Results: There were four cases of local recurrence (9%), two in each group. Three patients in the cement group required revision because of joint degradation in two and cement intrusion into the joint in the third. In the allograft group, two patients developed complications (fracture and massive resorption). Plan x-rays revealed joint deterioration in 10/17 patients with an allograft. The difference was significant (p=0.019).

Conclusion: The rate of local recurrence and complications after reconstruction requiring a revision procedure was not significantly different in the two groups. There was however a significantly greater radiographic degradation in patients with a bone defect filled with cement compared with those with a defect filled with a fragmented allograft.


Fabrice DELÉPINE Gérard DELÉPINE

Purpose of the study: Infection is the most severe orthopedic complication observed after conservative surgery. The purpose of this study was to ascertain the incidence and causes of such infection and analyze progress achieved over the last ten years.

Material and methods: From 1983 to 2004, surgical procedures were performed in more than 600 patients with bone sarcomas; 520 underwent reconstruction with a prosthesis and/or massive allow graft and were followed for at least six months. Age ranged from 4.5 to 82 years. Deep infections occurred in 47 patients requiring one or several revisions. Three other cases of infection, in patients initially given in other institutions, were included in the series. The study population thus included 50 deep infections after massive reconstruction. Forty-five of these patients had received chemotherapy and 20 radiotherapy. All patients were given adapted antibiotic therapy. Four patients required emergency amputation, and cleaning was attempted in 26. When the infection persisted, or when the infection became chronic, implanted material was removed systematically with insertion of an antibiotic-loaded spacer (gentamycin alon before 1990 then gentamycin+vancomycin). Reimplantation was attempted three to six weeks later when the laboratory results were satisfactory and the muscular and cutaneous situation was sufficient.

Results: Mean follow-up after infection was 8.5 years. At last follow-up, amputation had been necessary in 21 of the 50 patients. The limb was intact in the 29 others but the prosthesis could be reimplanted in only 27 after an average of 2.4 operations. The statistical analysis demonstrated that radiotherapy is a factor of poor prognosis (14 amputations in 20 radiotherapy patients versus 7 amputations in 30 patients without radiation) and that adjunction of vancomycin into the spacer cement has a beneficial effect (15 amputations in 23 patients without vancomycin versus 6 amputations in 27 patients with vancomycin.

Conclusion: Infection of a massive prosthesis is the most serious orthopedic complication because limb survival is compromised. Preventive treatment is crucial: radiotherapy should be avoided and duration of aplasia limited by the use of hematopoietic growth factors. Curative treatment can be achieved with early removal of implanted material, surgical cover with a muscle flap, and adjunction of vancomycin to the spacer cement. The role of prolonged systemic antibiotics remains controversial.


David BIAU Antoine BABINET Valérie DUMAINE Philippe ANRACT

Purpose of the study: Composite knee prostheses using a massive implant and an allograft is one option for joint reconstruction after extensive resection of the knee joint for bone tumor. Implant survival after resection of the proximal tibia is not well documented. We analyzed survival and complications in 26 composite knee prostheses.

Material and methods: A composite prosthesis was implanted in 26 patients after resection of a tumor of the proximal tibia. Median length of resection was 14 cm (range 9–20 cm). A GUEPAR massive implant was used in all cases. Allografts were sterilized with gamma radiation. Median length of the tibial stem was 30 cm (range 20–38 cm). The stem was cemented in the allograft and in the tibia.

Results: Median patient survival was 68 months. At last follow-up, 19 patients were living disease free. Among the 26 allografts, seven had fractured and five were partially resorbed. Seven allografts exhibited signs of fusion at the junction with the recipient bone. Seven reconstructions of the extensor system failed (rupture). Conversely, there were no ruptures in patients whose extensor system could be preserved (continuity) at tumor resection. Six composite prosthesis were infected, four early (< 2 months) and two late. There were four cases of local recurrence. Globally, 48 secondary procedures were required in 21 patients: 26 for mechanical defects, 13 for infection, 7 for local recurrence and 2 for postoperative complications (necrosis of the tibialis anterior in both). There were 14 revisions: 9 composite prostheses were replaced, fusion was performed in 2 patients, and 3 patients required amputation. Median survival of the reconstructions, considering all failures together, was 102 months (95%IC 64.3-Inf). Median survival, including all failures for local recurrence, was 105 months (95%IC 101-Inf).

Discussion: The rate of failure and of complications is high for massive knee prosthesis combined with a radiated allograft for reconstruction of the proximal tibia. There is no series reported in the literature. When possible, the extensor system should be preserved.

Conclusion: We currently use massive knee prostheses without allografts, reconstructing the extensor system with a vastus medialis flap.


David BIAU Philippe ANRACT Florent FAURE Eric MASCARD Antoine BABINET Valérie DUMAINE Valérie LAURENCE

Purpose of the study: The rate of failure can be high for massive reconstruction prostheses after tumor resection. We studied the causes and possible factors of failure.

Material and methods: The series included 91 patients who underwent surgery from 1972 to 1994 for resection of a bone tumor involving the knee joint. A GUEPAR prosthesis was implanted in all cases for reconstruction (megaprosthesis in 58 cases and composite prosthesis in 33). The extensor system had to be reconstructed in 37 patients. A GUEPAR II implant was used in 73 patients; 48 of these implants had an antirotation system. The analysis was retrospective. Outcome was studied in terms of survival and independent factors predictive of failure unrelated to the tumor.

Results: Mean follow-up was 72 months. At last follow-up, 68 patients were living disease free. There were nine cases of rupture of the extensor system. Preservation of a continuous extensor system at the time of bone resection reduced the risk of rupture (p=0.036). Seven allografts fractured, two loosened, and six became infected. Use of an allograft did not reduce the risk of loosening (p=0.17). Intraxial laxity was observed in 17 patients. Use of an antirotation system was a factor of risk of intraxial laxity (p=0.0023) but not of aseptic loosening. Aseptic loosening was observed in 18 patients: 10 femur reconstruction and 8 tibia reconstruction. The difference was not significant (p=0.6). In all, 104 revisions were required in 53 patients; 36 revisions of the prosthesis, 23 of them for mechanical causes. Overall median survival, excepting tumor-related causes, was 130 months. It was 130 months for femur reconstructions and 117 for tibia reconstructions (p=0.57). Age, length of resection, tumor location, use of an allograft, and use of an antirotation system were not found to be significant prognostic factors for implant survival.

Discussion: As reported by many others, we found that the rate of failure of massive prostheses for infectious and mechanical causes remained high in patients treated for bone tumors involving the knee joint. Survival of massive implants is much lower than that of gliding prostheses.

Conclusion: Technical progress is required to improve the survival of massive implants used for the treatment of bone tumors involving the knee joint.


Claude ABI-SAFI Antoine BABINET Valérie DUMAINE Bernard TOMENO Philippe ANRACT

Purpose of the study: Diagnosis and treatment of primary malignant tumors of the pelvis raise difficult problems. The purpose of this retrospective study was to analyze the functional and cancerological results observed after surgical treatment in a single center.

Material and methods: Between 1973 and 2002, 24 patients (16 men and 8 women) underwent surgery in our unit for histological proven malignant tumors. A posterior approach was used for curettages and sacrectomies of the apex. A combined anterior and posterior approach was used for total sacrectomy and hemisacrectomy. Oncological results were assessed in terms of local recurrence, presence of metastasis and patient status at last follow-up. Overall survival and disease-free survival were calculated with the Kaplan-Meier method.

Results: Mean age was 53.38 years. Mean follow-up in our series was 54 months. Mean time to diagnosis was 16 months. Pain was the predominant symptom. Sixteen patients presented neurological manifestations and the digital rectal examination was positive in all. Chondroma was the most frequent histological type (18/24). None of the patients had metastatic disease at diagnosis. A posterior approach was used for 15 patients and a combined approach for the others. There was a clear correlation between type of resection and volume of blood loss (p=0.0002). Wide dissection was wide in five patients, marginal in five and oncologically insufficient in 14. Mean operative time was 1.34 hours for posterior approaches and 9 hours for combined approaches. The postoperative period was uneventful for ten patients. Infection was the most frequent complication. Adjuvant radiotherapy, delivered in 16 patients, effectively retarded the occurrence of local recurrence. Functional disorders were correlated with the level of the neurological sacrifice. At least one S3 root had to be preserved to limit the urological and digestive incapacity. At last follow-up, local recurrence was present in 12 patients. Mean time to first recurrence was 32 months. There was a strong correlation between quality of the resection and time to local recurrence. There was a significant difference between patients with a wide resection and those with an oncologically insufficient resection (p=0.0312). Five patients had metastases. Five-year actuarial survival was 73±12%. At ten years it was 32±14%. Local recurrence-free survival was 55±11% at five years and zero at 10 years.

Discussion and conclusion: In light of these results, factors of poor prognosis were: late diagnosis, soft tissue invasion, proximal extension, marginal or insufficient resection.


Xavier FLECHER Jean-Manuel AUBANIAC Alessandro CASIRAGHI Jean-Noël ARGENSON

Purpose of the study: Acetabular dysplasia is a recognized cause of premature hip degeneration. With increasing use of arthroplasty, the role of conservative treatment can be debated. The purpose of this work was to describe technical advances achieved with Ganz triple periacetabular osteotomy and evaluate long-term results.

Material and methods: This study included 32 dysplastic hips in 28 patients treated by Ganz triple osteotomy and assessed a mean 12 years follow-up (range 2 – 20 years). Mean age was 32 years (range 18–47). There were 24 women and four men. Hip joint measurements were made on preoperaive standard x-rays with complementary recentered views if needed as well as computed tomography (CT) to better distinguish progressive degeneration. For early patients, the iniail osteotomy involved three cuts (ilioischial, iliopubic, ilial) starting close to the acetabulum and performed via three approaches: sub coxofemoral, intrapelvic, extrapelvic. The first technical change involved osteotomy of the anterosuperior iliac spine and an oblique iliac cut farther from the acetabulum.

Results: Mean preoperative angles were: 135° (121 to 150°) for CC’D, 23.2° (3 to 40°) for HTE, 8.4° (−14 to 22°) VCE, 11.3° (−26 to 32°) for VCA. The postoperative values were: 134.5° (121 to 150°) for CC’D, 9.5° (−9 to 20°) for HTE, 31.7° (14 to 60°) for VCE, 31.7° (10 to 48°) for VCA. Six patients required total hip arthroplasty on average four years later (range 2 – 9 years), including one patient with aseptic necrosis of the acetabulum.

Discussion and Conclusion: This study confirms the usefulness of triple periacetabular osteotomy for conservative treatment of acetabular dysplasia. In light of our results, the following changes have been instituted:

all three cuts are performed via a single intra-pelvic approach;

For severe extreme dysplasia (Hip Study Group classification), a two-thirds triple osteotomy is performed (original technique). Currently the best indication appears to be a young patient (less than 30 years) with moderate to severe dysplasia, without intra-articular suffering and without any sign of early stage joint degradation.


Hassan SADRI Pierre HOFFMEYER

Purpose of the study: Coxofemoral conflicts can sometimes lead to early degenerative disease in young patients. Open surgery for surgical dislocation with joint cleaning had provided promising short- and mid-term results. Arthroscopy of the hip joint is a less invasive alternative. The purpose of this work was to compare prospectively the outcome achieved with open surgical or arthroscopic treatment of coxofemoral conflicts after a minimum follow-up of two years.

Material and methods: Sixty-three patients, mean age 30 years (range 19–54) with arthroMRI-proven coxofemoral conflict were evaluated two years after treatment. Surgical dislocation was used for 31 patients and arthroscopy for 32. Clinical outcome was assessed on the basis of WOMAC scores noted preoperatively, postoperatively and at two years follow-up. Complications were noted.

Results: Results were similar in the two groups at two years: preoperative WOMAC score: 65/100 (41–95) pour open dislocation, 57/100 (15–96) for arthroscopy; postoperative WOMAC score at two years: 79/100 (41–99) for open dislocation, 84/100 (50–99) for arthroscopy. The rate of patient satisfaction was similar: (open dislocation: 75% and arthroscopy: 82%). Complications: open dislocation : 3 case of POA including 1 Brooker stage III and one 1 case of ossifying myositis of the thigh; arthroscopy: 2 case of hematoma (spontaneous resolution) and 1 case of transient irritation (48 h) of the lateral femoral cutaneous nerve. Surgical revisions at two years: open dislocation: one total hip arthroplasty at 15 months and one resection of ossification (POA) at 15 months; arthroscopy: two total hip arthroplasties at 5 and 15 months.

Discussion: The results obtained with the two methods are encouraging at two years. A satisfaction rate of 80% can be expected.

Conclusion: Arthroscopy appears to be the more advantageous alternative for young patients since it is less invasive and provides similar results at two years.


Horacio CAVIGLIA

Purpose of the study: Hemophilic pseudotumor is actually an extended encapsulated hematoma which produces clinical symptoms related to its anatomic position. It is more a clinical entity than a pathological lesion. From 1990, precutaneous aspiration was proposed for significant cysts and pseudotumors treated at the Mariano R. Castex Institute. After aspiration, the cavity was filled with a bone graft for larger tumors or with spongostan or fibrin glue for smaller defects. The pseudocapsule was not removed. We report here results obtained in 17 patients.

Material and results: The 17 patients (all males) presented 19 cysts, mean age 21 years. All had hemophilia (16 A, 1 B), five were HIV-positive, nine were seropositive for hepatitis C and two presented inhibitors. All patients received coagulation factors. One patient died from histoplasmosis. Cure and successful filling of the bone defect was achieved in 15 patients. Revision for conventional resection was required in one case of recurrence.

Discussion: Percutaneous aspiration is a minimally invasive method which enables restoration of the bone tissue. We have not observed any difference between HIV-positive and HIV-negative patients.


Paul BEAULÉ Michel LE DUFF Norah HARVEY

The femoroacetabular conflict is a recognized cause of hip pain in young patients. It is associated with rim tears. Two types of conflict have been described: impingement due to retroversion of the acetabulum and «cam effect» associated with insufficient head/neck offset. A recent subject of debate has been isolated treatment of the rim tear without treating the often unrecognized bone anomaly. The purpose of this study was to assess short-term outcome after surgical remodeling of the head/neck junction for the treatment of femoroacetabular conflicts.

Material and methods: There were 37 hips (18 men and 16 women) with chronic pain for more than three months. Mean patient age was 41 years (range 24–52). Preoperative 3D CT and MRI with gadolinium arthrography were available for all patients. Surgical remodeling of the head/neck junction via digastric trochanterotomy with surgical dislocation was performed. Preoperatively, the mean Notzli alpha angle was 65.6° (range 42–95°). Among the 34 patients, only four practiced sports requiring large range hip motion. MRI revealed a rim lesion in all patients. The following tests were performed: UCLA hip test, WOMAC (Western Ontario McMaster Osteoarthritis) index, and SF-12.

Results: Mean follow-up was 2.5 years (range 2–4); pre- and postoperative scores were: WOMAC 59.2 and 81.0 (p< 0.001), UCLA scores 4.2 and 7.9 for pain, 7.3 and 9.0 for gait, 6.2 and 8.5 for function, 4.3 and 6.9 for activity (p< 0.05). The physical component of the SF-12 improved from 37.4 to 44.2 (p< 0.006) and the mental component from 46.0 to 51.6 (p< 0.03). None of the hips required revision to modify the joint configuration. Two complications were noted: one rupture of the greater trochanter and one heterotopic ossification requiring resection. Osteonecrosis was not observed. The trochanter implants were removed in nine patients because of pain.

Discussion: The femoroacetabular conflict results from insufficient concavity of the anterolateral head/neck junction associated with a rim tear. Correction of the bony anomaly provided significant short-term functional improvement both for the hip and for the patient’s general health. Correction of the offset by surgical dislocation of the hip is effective and safe treatment of the femoroacetabular conflict with preservation of the rim.


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Ivan GOROSITO Carla BARTOLUCCI

Osteoid osteoma is a benign bone tumor usually observed in children and adults, generally in the femur or tibia. Pain relief with aspirin is a classical clinical characteristic. Computed tomography is the exploration of choice providing reliable diagnosis. Cure can be achieved with surgical resection. We present an exceptional case of osteoid osteoma located in the patella.


Hassan SADRI Pierre HOFFMEYER

Purpose of the study: Coxofemoral conflicts can sometimes lead to early degenerative disease in young patients. Hip arthroscopy is a less invasive alternative which can remove all of the coxofemoral conflicts. Like open surgery, a purely arthroscopic technique enables all the necessary corrections, even involving the rim. Arthroscopy has provides promising short- and mid-term results. The purpose of this work was to present the surgical technique, its drawbacks and complications, and present suggestions for improvement.

Material and methods: Fifty-one patients, mean age 31 years (range 15–54 years) underwent purely arthroscopic treatment of coxofemoral conflicts between February 2001 and November 2003. Prospective follow-up was at least six months. The type of conflict and the corresponding corrections were noted. The Pre- and postoperative WOMAC scores were used for clinical assessment. Complications were noted as well as means for avoiding them.

Results: The operative technique, the potential dangers, and suggestions for successful arthroscopy are presented. The clinical outcome with at least six months follow-up was: hip R/L: 21/31. Head and acetabular correction: 46 cases. Head correction alone (head/neck offset): 5 cases. Preoperative WOMAC score: 59/100 (15–99). Postoperative WOMAC score: 85/100 (49–99). Complications: spontaneously resolutive hematoma (n=2), transient (48h) irritation of the lateral femoral cutaneous nerve (n=1).

Discussion: Purely arthroscopic correction of a coxofemoral conflict is as safe as the open surgical technique. The arthroscopic method provides very promising short- and mid-term results with no major complications. The lower morbidity with this technique enables ambulatory treatment with shorter recovery time.


Eric VANDENBUSSCHE Mohammed SAFFARINI Nicolas DELOGE Michaël NOGLER Adnan CAVUS José-Luis MOCTEZUMA

Purpose of the study: The anterior rim of the arthroplasty cup can overhang the bone in certain situations: oversized cup, insufficient anteversion, insufficient ace-tabular reaming, cylindrospherical reaming overriding the acetabular opening. The straight or concave shape of the anterior wall of the acetabulum also affects prosthetic overhang. The purpose of this anatomic study was to use a navigation system to quantify, in vitro, the height of the iliopubic psoas notch.

Material and methods: Sixty-eight acetabuli from 34 cadaver pelvi free of osteoarthritis (13 male and 21 female) were analyzed using the Stryker™ hip navigation system. Morphological data were collected for mathematical processing which defined the diameter and the center of the articular surface.

Results: Considerable intra- and inter-individual differences in the shape of the acetabular rim were noted and quantified, particularly concerning the psoas notch. When the lateral view of the acetabular rim is projected onto a plane it produces a succession of three summits and three valleys explaining the difficulty encountered in obtaining a precise mean plane for the acetabular opening.

Discussion: More or less pronounced protrusion of the cup could explain potentially painful anterior impingement of the psoas, especially for certain types of acetabular morphology.


Didier MAINARD Laurent GALOIS Stéphanie VALENTIN

Purpose of the study: Correct positioning of the prosthetic cup requires reliable anatomic landmarks, particularly for navigation systems. Referring uniquely to the three dimensions fails to recognize interindividual differences in pelvic position. The anterior plane of the pelvis is a good indicator of the pelvic position which can be determined from radiographic measurements. Standard values are poorly known (age, gender, weight). The purpose of this study was to measure the APP radiographically in the upright and reclining positions before and after total hip arthroplasty and to correlate the observed values with those obtained with navigation and ultrasound.

Material and methods: Strictly standardized x-rays of the pelvis in the upright and standing position were obtained in 110 patients (40 men, 70 women, mean age 65 years). Films which did not meet strict standard criteria were removed from the analysis which thus included upright views in 57 patients, reclining view in 36, and upright and reclining views in 28. Navigation measurements were made in 20 patients and ultrasound measurements in 10.

Results: Before arthroplasty, anteversion was 6.42±6.9° in the reclining position, 0.29±7.39° in the upright position (significant difference). After arthroplasty, anteversion was 6.9±5.3° in the upright position and 0.28±5.03 in the reclining position (significant difference). The values ranged from −15° to +18° (three patients without change, four with anteversion). There was no significant difference by gender. There was no clear correlation between the navigation values and those measured on the standard x-rays. The navigation and ultrasound values appeared to be correlated.

Discussion: The anterior pelvic plane can be easily measured on standard x-rays (upright and reclining position). Its landmarks can be easily accessed by navigation enabling the constitution of a reference plane. Several authors have demonstrated the influence of pelvic tilt on the position of the prosthetic cup. Posterior tile produces acetabular anteversion and inversely. The difference between the reclining and upright position is to the order of 6°. There are however variants up to 20° observed in certain patients and which might explain malpositions or instabilities. A cup with correct anteversion in the reclining position may be malpositioned on the upright film because of pelvic tilt.

Conclusion: Pelvic tilt should be taken into consideration when positioning the cup. The anterior pelvic plane can be correctly measured on standard x-rays and used to evaluate this tilt then serve as a reference for navigation. It should be proposed in all patients to search for extreme values.


Frédéric PICARD Gilles SCHOCKMEL François LEITNER Philippe MARTIN

Purpose of the study: Knee prosthesis surgery has reached a high level of reproducibility, providing very satisfactory results in the large majority of patients. There remains however a certain lack of precision concerning this surgical procedure concerning the determination of the hip center. This point is used to establish the mechanical axis of the femur for positioning the prosthesis. Navigation systems can be used to localize this center. We conducted a cadaver study to determine the accuracy and repeatability of this method for determining the center of the hip joint.

Material and methods: A computerized navigation system was applied to seven fresh cadavers with normal hips. We compared the anatomic center of the hip joint with the point determined with the navigation system. We also compared the navigation technique using different navigation techniques: marker fixed on the iliac crest and without marker fixed on the iliac crest. We also determined the accuracy of the result as a function of hip circumduction during acquisition (5°, 8°, 10°).

Results: There was no statistical difference between investigator A (0.66±0.15, max error: 0.99) and B (0.68±0.10, max error: 0.87), p=0.98 (inter or intra-observer) for comparisons between the anatomic center of the hip joint and the point determined by the navigation system. The results were not statistically different between the navigation techniques (with and without a marker fixed on the iliac crest):(mean < 0.71 ± 032, max. error: 1.91) for each hip with the iliac marker (0.66 ± 0.20, max. error max: 0.99) or without the iliac marker (0.61 ± 0.41, max. error: 1.29) for hip 1. Accuracy was better for hip movement at 10° (0.60 ± 0.21, max. error: 0.92) than at 8° (0.81 ± 0.52, max. error: 1.91) or at 5° (0.67 ± 0.46, max. error: 1.91). In addition, without an iliac crest marker, 75% of the errors were less than 1, and 95% less than 1.5.

Discussion: Acquisition of the hip center of rotation using a computerized navigation system with or without use of markers fixed on the iliac crest is remarkably accurate.

Conclusion: New algorithms and control systems should help improve reproducibility above that obtained with the conventional technique.


Sébastien PARRATTE Jean-Noël ARGENSON Xavier FLECHER Jean-Manuel AUBANIAC

Purpose of the study: Malposition of the acetabular implant of a total hip arthroplasty can provoke dislocation, limited joint movement, and early wear. The purpose of this prospective randomized study was to assess the efficacy of a image-free navigation system to achieve correct acetabular position for total hip arthroplasty.

Material and methods: The navigation software for the acetabular component used intraoperative anatomic acquisition. The prospective randomized study included two groups of 20 patients. In the first group, the acetabular implant was inserted using the computer-assisted system and in the second using the conventional method. The same operator performed all procedures via an anterolateral approach and using the same non-cemented hemispheric cup. The postoperative assessment was performed by an independent investigator who noted the cup inclination on the standard ap view and cup anteversion on the computed tomography; then using a dedicated system for 3D reconstruction, the same values were determined one month after surgery.

Results: Each group included ten men and ten women, mean age 63 years and mean body mass index 24. For the computed-assisted group, mean additional operative time for navigation was 13 minutes (range 8–20 min). The intraopeartive concordance with the surgeons subjective impression was excellent for 12 patients and good for 8. Mean intraoperative values were for the computer-assisted group were: for operative mode: inclination 30° (25–46°), anteversion 14° (0–25°), radiographic mode: inclination 35° (25–47°), anteversion 13° (0–26°), anatomic mode: inclination 36°, anteversion 19° (0–27°). There was no significant difference between the intraoperative and postoperative values for the computer-assisted group. There was no significant difference between the average values between the computer-assisted and conventional groups but the standard deviation was smaller in the computer-assisted group.

Discussion and conclusion: The image-free navigation system enables reliable positioning of the prosthetic cup for total hip arthroplasty and increases the precision of acetabular implantation without increasing significantly operative time. This first step must be integrated into the computerized preoperative planning for total hip arthroplasty. The next step will be to use the navigation system for implanting the femoral component.


Jérôme TONETTI Yong-San YOON Antony HODGSON Donald GARBUZ

Purpose of the study: Dislocation of total hip arthroplasty remains a frequent complication, occurring for 0.5% to 10% of implants depending on the series. In about 30% of the cases, the orientation of the acetabular cup is involved. It is sometimes difficult to visualize the acetabular landmarks during surgical procedures performed for revision or with a minimally invasive technique. The surgeon uses the position of the pelvis on the operative table as a guide. It can be noted however that the patient’s weight bearing on the table is not constant during the entire operation, potentially changing the position of the pelvis during the procedure. We evaluated the use of a visual referential visible within the operative field for implanting the prosthetic cup.

Material and methods: The method materialized the anterior plane of the pelvis then transferred geometrically this plane for display on the ipsilateral iliac crest. The pelvis was masked under a drape, in lateral decubitus. The cup was implanted 12 times using the plane of the floor as the reference, 8 times using the acetabular rim as the reference, and 10 times using the iliac reference. The goal was 20° anteversion in the sagittal plane and 45° inclination in the frontal plane. The position of the pelvis was randomized. The final positions of the cup, of the iliac reference, of the anterior plane of the pelvis and of the floor were recorded with an optical system. Spearman’s test was used to search for correlations.

Results: Using the floor referential, mean anteversion was 21.8° (15–30.9°) and mean inclination 43.2° (37–47.6°). Using the acetabular referential, mean anteversion was 21.7° (18.1–26.6°) and mean inclination 45.8° (40.9–48.6°). With the iliac referential, mean anteversion was 20.3° (17.3–25.5°) and mean inclination 43.3° (41.1–44.8°). Mean error between the pelvic plane and the iliac referential was, for anteversion −0,32° (−1.07 to 0.8°) and for inclination, −0.1° (−0.95 to 1.43°). Implantation with the iliac referential was not correlated to the position of the pelvis. When the plane of the floor was used, the position of the implant was correlated with pelvic anteversion (p< 0.01) and inclination (p< 0.01).

Discussion: Insertion of the cup was independent of the position of the pelvis within a 3D referential in the operative field. In addition to computer-assisted navigation, simple tools can be developed to improve the surgeon’s perception in difficult indications, especially when they can provide satisfactory accuracy. A clinical feasibility study is currently under way.


Paul BEAUL Patricia CAMPBELL Ryan HOKE

Purpose of the study: During resurfacing arthroplasty, excessive valgus of the femoral neck or an insufficient surgical technique can lead to formation of a notch in the femoral head. Although the mechanisms weakening the femoral neck and subsequent fractures are well described, the effects of altered blood supply via the retinacular vessels on potential ischemia of the femoral head are largely unknown. The purpose of our study was to assess blood supply to the femoral head when a notch occurred in the femoral neck during total hip replacement surgery and to deduct possible implications concerning the resurfacing procedure.

Material and methods: Blood supply to the femoral head was measured with laser Doppler fluorometry in 14 hips undergoing total hip replacement for osteoarthritis via a lateral approach with anterior dislocation. An optical laser probe for the fluorometry (Moor Instruments, Wilmington Delewar, 20 mW laser, probe length 780 nm) was introduced via a 3.5 mm hole drilled in the antrolaeral quadrant of the femoral head (leg in neutral position). The position of the probe was checked on the x-ray of the femoral head after resection. A notch was simulated in the lateral posterior portion of the femoral neck using a bone gouge.

Results: Mean patient age was 65 years (range 48–77 years). There were eight men and six women. Two measurements were made: one after dislocation of the hip and the second after simulating the notch. A significant decrease in blood supply measured at more than 50% was observed in all but four hips after simulating the notch. The median decrease in blood flow was 76% (4.4–90.4, p< 0.001).

Conclusion: The retinacular vessels appear to be equally important for the blood supply for osteoarthritic and non-osteoarthritic femoral heads. A notch occurring during hip resurfacing would not only weaken the mechanical resistance of the neck but would also increase the risk of osteonecrosis and subsequent loosening of the femoral component. Consequently, approaches compromising retinacular blood supply (for example the posterior approach) would add a supplementary danger for the integrity and viability of the femoral head.


Yannick PINOIT Henri MIGAUD Philippe LAFFARGUE Jacques TABUTIN François GIRAUD Jean PUGET

Purpose of the study: Most systems used for computer-assisted total hip arthroplasty require preparatory computed tomography acquisition or use of multiple bone markers fixed on the pelvis. In order to overcome these problems, we developed a novel system for CT-free computer assisted hip surgery based on a functional approach to the hip joint. The concept is to orient the cup within a cone describing hip motion. The purpose of the present study was to analyze preliminary results obtained with this new system.

Material and methods: This new system was used to implant 18 primary total hip arthroplasties in 16 women and 2 men (mean age 68±7.8 years, age range 54–83 years) with degenerative disease. Two optoelectronic captors were fixed percutaneously on the pelvis and the distal femur. The acetabulum was reamed, then the femur prepared with instruments of increasing caliber. The last reamer positioned in the shaft carried an upper head which matched the size of the prepared acetabulum. Hip joint motion was recorded to determine the cone of maximal hip mobility. The system then oriented the cup so that this cone was completely included the cone described by the prosthesis.

Results: There was one traumatic posterior dislocation (fall in stairs) at three weeks, without recurrence. The Postel Merle d’Aubigné score improved from 8±2.9 (3–12) preoperatively to 17±0.8 (16–18) at last follow-up. None of the patients complained about the sites where the percutaneous markers were inserted and ther were no cases of hematoma or fracture. Mean leg length discrepancy was 5.6±7.5 mm (range 0–25 mm) before surgery and 0.6±3 mm (range −5 to 10 mm) at last follow-up. Mean anteversion of the femoral implant was 22.3±6.7° (14–31). Anatomic anteversion of the cup (measured from a marker linked to the pelvis and thus independently of the position of the pelvis) was 25.9±10.4° (12–40). The sum of the femoral and acetabular anteversions was 48.2±14.6° (range 27–71°).

Conclusion: This method can be used in routine practice without lengthening operative time excessively. It provides a safe way to control the length of the limb and helps position the cup. This study demonstrated that there is no ideal position for the cup that can be applied for all patients. Because of the wide spread of the inclination and anteversion figures, half of the cases were outside the safety range recommended by Lewinnek.


Gérard POUGET

Purpose of the study: The extramedullary anatomy of the femur must be reproduced during total hip arthroplasty in order to ensure correct tension on the gluteus muscles. This requires:

correct offset of the femur, measured as the distance between the center of the head and the anatomic axis of the shaft;

offset of the center of rotation, measured as the distance between the center of the head and the pubic symphesis. Addition of these two offsets gives the overall offset. The purpose of this work was to analyze postoperative offset after standard total hip arthroplasty as a function of the preoperative head-shaft angle.

Material and methods: Prospective study of 150 files of patients who underwent first-intention total hip arthroplasty. A prosthesis with matched increasing head size was implanted. The head-shaft angle was 135°. Mean offset was 41.7 mm (range 33–47 mm) for the 0 head-neck. The preoperative neck-shaft angle was measured on the upright ap view (comparable rotation of the two hemipelvi). Pre- and postoperative femur and center of rotation offset were noted.

Results: The preoperative neck-shaft angle varied from 118° to 1400. Mean preoperative femur offset was 40.2 mm (range 29–52 mm). Mean postoperative femur offset was 42.2 mm. This gave a 2 mm lateralization of the femur, which was apparently negligible, favorable, and therefore satisfactory. Mean offset was 90.5 mm preoperatively and 84.5 mm postoperatively, medializing the center of rotation 6°. Mean overall offset was thus displaced medially (6 mm minus 2 mm = 4 mm). This was considered acceptable. Among these 150 files, 24 were coxa vara hips with a neck-shaft angle 125°. For these 25 coxavara hips, the mean preoperative femur offset was 44.5 mm. The mean postoperative femur offset was 42.2 mm. This produced, inversely, a medial displacement of the postoperative femur offset of 2.3 mm. The center of rotation was displace medially 6 mm. Thus globally the medial displacement was 6 mm plus 2.3 mm = 8.3 mm. This appeared to be excessive.

Discussion: The postoperative offset of the femur is prosthesis-dependent. The majority of implants currently marketed have a mean offset in the 40–45mm range. The offset of the center of rotation is operator-dependent: as the acetabular reaming is accentuated, the center of rotation is displaced medially. Acetabular reaming is necessary to reach the subchondral bone. The medial offset can be limited but at least some displacement is inevitable. Thus in the event of a coxavara hip, it is very difficult to limit excessive overall medial offset when using a standard prosthesis. If the goal is to mimic the anatomic femur offset, it would appear justified to use prostheses with a smaller neck-shaft angle for patients with coxavara. A 10° reduction, from 135° to 125° would increase the femur offset 5 mm and thus enable reproduction of the preoperative anatomy.


Blaise MICHEL Saïd SLIMANI Mostafa ABOULALA Patrick BLANCHOT Henry COUDANE Jean-Pierre DELAGOUTTE

Purpose of the study: Morton neurinoma is a well defined anatomic entity despite certain questions about the pathogenic mechanisms. Diagnosis of the metatarsalgia sometimes produced can be difficult due to the frequency of an associated static metatarsalgia. Magnetic resonance imaging has not met expectations. We have oriented our research towards ultrasonography which can provide high quality information with good reliability.

Material and methods: We reviewed the files of 11 patients with Morton neurinoma which led to 14 operations (bilateral cases or two localizations on the same foot). The series included three men and eight women, mean age 56 years. The operation was conducted under locoregional anesthesia and consisted in tumor resection via the plantar commissure, with removal of the entire neurinoma. Ultrasonography used a high-frequency probe (6–13 MHz linear scan). The compartments were studied via the plantar aspect and the dorsal aspect using static and stress positions. MRI had been performed in two patients before the ultrasound.

Results: Eight of the eleven patients had an associated syndrome (hallux valgus, disharmonious length with mid metatarsal weight bearing). Objective signs (Mudler’s sign, hyoesthesia), were noted in seven patients. The neurinoma was confirmed in all cases at surgery; in two cases, ultrasonography demonstrated a neurinoma where the MRI had been negative. The operative specimen was typical. Two compartments were explored because of the ultrasound results which were highly suggestive; two tumors were demonstrated at surgery. Clinical outcome at mean seven months was good in ten patients and fair in one.

Discussion: Ultrasonography should no longer be considered as «operator-dependent». It enables the detection of mid-sized neurinomas measuring about 2 cm. Magnetic resonance imaging has been less productive for diagnosis; many studies have been reported without surgical confirmation of MRI-negative cases. False negatives are frequent and patient follow-up is insufficient to determine whether the symptoms persist or resolve after surgery.

Conclusion: Ultrasonography is a simple examination devoid of iatrogenic risk. The use of stress images has greatly improved performance. This low cost examination may not however be necessary because the diagnosis of Morton is basically clinical.


Patrice-François DIEBOLD Walter MAC DOUGAL

Purpose of the study: The choice between preservation of the joint shape and straight cuts for arthrodesis of the metatarsophalangeal joint (MPJ) remains a subject of debate.

Material and methods: Sixty patients (74 feet), mean age 67 years, underwent fusion of the first MPJ. There were 52 women and 8 men. Follow-up was 38 months. The operation was performed with a tourniquet and locore-gional anesthesia. The procedure consisted in resection of the remaining cartilage and subchondral bone with preservation of the joint shape. Axial reduction was achieved with back-and-forth pinning the compression stapling on the dorsal aspect. The patient wore a postoperative boot for six weeks.

Results: mean time to healing was 15 weeks (rate of fusion 94.6%). The AOFAS score improved from 29.2/100 preoperatively to 77.1/100 postoperatively. 83% of patient resumed their normal activities. The mean M1P1 angle improved from 34.7° preoperatively to 23.8° postoperatively. Dorsal flexion was 26.8° postoperatively. 79.7% of patients were completely satisfied and 13.5% partially satisfied.

Conclusion: Arthrodeis of the first MPJ is a good technique for selected patients. Use of two dorsal staples for compression is more economical and gives the same rate of fusion as more sophisticated methods. Preservation of the joint shape has no influence on the rate of fusion. There is no mid-term impact on the interphalaneal joint.


Jean-François GONZALEZ Eric DEMORTIÈRE Emmanuel BUSSY Jacques LIMOUZIN Antoine BERTANI Michel DI SCHINO

Purpose of the study: Chronic foot compartment syndrome is a rather new notion illustrated by four cases reported in the international literature. We report a new case with bilateral involvement. The diagnosis was established by dynamic thallium scintigraphy and suggested that a less invasive management would be appropriate.

Case report: A 32-year-old male Foreign Legion recruit developed exercise-induced pain in the medial portion of the plantar aspect of both feet. The pain persisted for several months and resisted medical treatment. No medical or surgical event could be identified in the patient’s history. Pain developed systematically with exercise which had to be interrupted. It regressed progressively after interruption of exercise. The physical examination and podoscopy were not contributive. Laboratory tests, plain x-rays, MRI, and bone scintigraphy were normal. The diagnosis of chronic foot compartment syndrome was entertained. Dynamic thallium-201 scintigraphy was performed on both feet to compare the soft tissue images. Intense uptake was observed on the early images and late images of the plantar vault. These images, present on both feet, were considered compatible with chronic foot compartment syndrome. Positive diagnosis was confirmed with pressure measurements in the medial compartment. Fasciotomy was performed for the medial compartment. The patient was able to run normally at one month with complete regression of the symptoms. The patient was symptom free at two years.

Discussion: Compartment pressure measurements currently constitute the gold standard diagnostic approach. MRI, Doppler, spectroscopy, and scintigraphy have been proposed. For this functional disorder, which occurs only after exercise, we consider that compartment pressure measurement is overly invasive and painful. Furthermore, dynamic thallium-201 scintigraphy has been found to be as reliable as pressure measurements. Comparative studies would be required to determine the best evidence-based choice.

Conclusion: Chronic foot compartment syndrome is a rare entity observed in the active young subject. The medial compartment is always involved. Fasciotomy is effective treatment. Compartment pressure measurements remain the gold standard but dynamic scintigraphy would be a promising examination which merits evaluation.


Patrice-François DIEBOLD

Purpose of the study: When it became popular in the 1980s, the wedge osteotomy proposed by Kenneth John-son of the Mayo Clinic was not advocated for patients over 50 years of age. We wanted to known whether it could work in patients over 60.

Material and methods: Between January 1987 and December 1988, 62 patients underwent surgery for moderate hallux valgus. Wedge osteotomy was performed in all cases associated with phalangeal osteotomy and lateral release of the metatarsophalangeal joint (MTJ). Mean patient age was 60.2 years. Patients were followed ten years on average.

Results: Thirty-nine patients (48 feet) were reviewed. Radiological recurrence was noted in nine feet. The average hallux valgus M1P1 angle was 35° preoperatively and 9.8° postoperatively. The average M1M2 angle was 11.4° preoperatively and 4.6° postoperatively. Joint motion was good for the first MPJ, with average 51° dorsiflexion, and 14° plantar flexion. These results were obtained despite the opinion that wedge osteotomy stiffens the MTJ after 50 years. Patient satisfaction was very good, especially for shoe wearing, the esthetic result, and pain relief. Most recurrences involved non-correction of the distal articular angle, an observation which would be rather surprising in older patients. There were no cases of necrosis of the metatarsal head and the degenerative changes observed radiographically had little clinical impact.

Conclusion: This series has enabled us to conclude that the risk of wedge osteotomy of the metatarsal is not greater after the age of 60 years and that it provides very satisfactory long-term results.


Vincent STAQUET Xavier CASSAGNAUD Carlos MAYNOU Henri MESTDAGH

Purpose of the study: Scarf osteotomy is currently the gold standard treatment for hallux valgus. The purpose of our work was to search for anatomic and clinical factors affecting the outcome.

Material and methods: This retrospective review concerned 125 osteotomies performed in 105 patients (101 women and 4 men, mean age 48 years, age range 16–75 years). For 55 cases, Scarf osteotomy was associated with osteotomy of the proximal phalanx. Osteotomies to reduce the lateral metatarsals were performed in 32 cases. Clinical outcome was assessed in terms of pain, hallux function and motion using the AOFAS and Groulier systems. AP and lateral weight-bearing views were used to assess the metatarsophalangeal, intermetatarsal, interphalangeal, PPAA, DMAA, and Djian angles and metatarsal slope.

Results: Mean follow-up was 45 months (range 24–95). The Kiaoka and Groulier score improved respectively from 50 to 84/100 points and 38 to 68/100 points (p< 0.0001). Pain relief was total or nearly total in 95% of patients. MPJ stiffness was related to gastrocnemius retraction, osteoarthritic degeneration, and residual deformation (p< 0.05). Subjectively, 72% of patients were satisfied or very satisfied, corresponding to 73% good or very good results. At last follow-up M1P1, M1M2 and DMAA had decreased significantly (p< 0.001) respectively improving from 33° to 18°, 14° to 9.5° and 13.2° to 9.4°. Conversely, mean P1P2 and PAA increased significantly (p< 0.05) because certain inter- and intraphalangeal deformations, radiographically masked by the preoperative hallux pronation, were not corrected. There were 29 recurrences (MP angle > 25°) statistically related to under correction of the intermetatarsal angles (p< 0.0001), M1M5, DMAA (p< 0.05), persistent hallomegaly (p=0.015), and presence of an oblique cuenometatarsal space (p=0.02). Recurrence was more frequent in patients with flat foot (p=0.04); greater calcanceal valgus was associated with wider MP angle (p=0.02).

Discussion and conclusion: Scarf osteotomy enabled complee correction of 80% of the deformations. To improve the final outcome, displacement of the first metatarsal should correct the metatarsus varus and the DMAA. Careful radioclinical analysis pre- and intra-operatively should held detect posterior (flat foot) and anterior (hallomegaly, inter- and intraphalangeal crossover) of the MPJ because they significantly influence persistence or recurrence of the deformation.


Olivier JARDÉ Antoine DAMOTTE Joël VERNOIS Raphaël COURSIER Stéphanie DELELIS

Purpose of the study: Hallux valgus is often associated with metatarsalgia due to insufficiency of the first ray. The purpose of this prospective study was to learn whether osteotomy of the first metatarsal can correct both conditions.

Material and methods: This series included 35 women and 2 men, mean age 55 years. Metatarsalgia predominated in M2 in these patients with a round forefoot. Pain was a constant sign. Thirty-six patients wore special shoes for comfort with or without an orthesis. The mean preoperative metatarsal varus, measured radiographically was 16°. Scarf osteotomy used a horizontal cut at of the first metatarsal forming a 45° angle with the plantar aspect. Patients were reviewed at three years with a computed tomography of the forefoot. The Kita-oka score was determined.

Results: Thirty-four feet were pain-free at last follow-up. The frontal scan of the forefoot showed the shaft of the first metatarsal had been lowered 2 mm on average. According to the Kitaoka score, outcome was good or very good for 31 feet, fair for 5 and poor for 5. There was a significant correlation between lowering of the first metatarsal and persistent metatarsalgia.

Discussion: Barouk suggested the Scarf technique does not enable sufficient lowering of the first row to correct for around forefoot. The CT scan however showed the metatarsal was lowered 2 mm, which would appear to be sufficient to correct for the insufficient weight-bearing. The result of this series would appear to show that outcome is better then hallux valgus cure plus Weil oseotomy if there is no hallomegaly.

Conclusion: This series shows the usefulness of lowering the first metatarsal for the treatment of hallux valgus with metatarsalgia without hallomegaly.


Ikbal FARHAT Eric DEMORTIÈRE Jean-François GONZALEZ Alexandre ROCHWERGER Georges CURVALE

Purpose of the study: The efficacy of metatarsophalangeal joint (MPJ) fusion for the treatment of hallux rigidus has been well defined in the literature. There is however still some debate about the efficacy of conservative treatment, especially concerning the respective role for each of several different techniques.

Material and methods: This study reports the analysis of 113 patients treated for hallux rigidus with minimum one year follow-up. Mean age of this predominantly female population was 58 years. Fusion of the MPJ of the great toe was performed for 77% of patients and conservative treatment for 23%: isolated osteophytectomy (n=5), dorsal cheilectomy and shortening osteotomy of P1 (5 cm on average) with or without dorsal flexion for the others. The clinical outcome was assessed with the Groulier criteria.

Results: Overall outcome was satisfactory in 85% of the patients treated by MPJ fusion; MPJ pain resolved in 92%. There was however late healing or nonunion in 13% with no apparent clinical impact. Conservative treatment successfully relieved pain in 80% of patients who were able to wear ordinary shoes and had improved dorsal flexion of the MPJ.

Conclusion: The results of this study are helpful in determining the appropriate indications for surgery as a function of the clinical and radiological presentation of hallux rigidus.


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Gérard ASENCIO Pascal KOUYUOMDJIAN Walter MAC DOUGAL Raoul BERTIN-CASTELLAN Soria HACINI

Purpose of the study: The place for total ankle arthroplasty versus fusion remains a subject of debate for the treatment of painful stiff ankles.

Material and methods: This series included 58 total ankle arthroplasies performed in 56 patients between 1991 and 2003. Mean paient age was 52 years (range 27–84). The underlying cause was multiple trauma (n=27), rheumatoid arthritis (n=17), chronic instability (n=11), hemophilia (n=2), primary disease (n=1). Four implants were used: New Jersey (n=22), Albatros (n=4), Star (n=10), AES (n=22). Associated procedures were: lengthening of the Achilles tendon or vastus (n=28), lateral ligamentoplasty (n=6), fibular osteotomy (n=2), medial ligamentoplasty (n=1), calcaneal osteotomy (n=3), double arthrodesis (n=1). The patients wore a plaster cast for 21 to 40 days.

Results: Eight patients were removed from the analysis: death (n=4), foreign residence (n=1, 3 follow-up shorter than one year (n=3). The analysis retained 50 total ankle arthroplasties in 48 patients reviewed with a mean 49 months follow-up (range 1–12 years). Reasons for surgery were: trauma (n=25), rheumatoid disease (n=12), instability (n=10), hemophilia (n=2), primary (n=1). Implants were: New Jersey (n=17), AES (n=19), Star (n=9), Albatros (n=3). Complications were: intra-operative medial malleolar fractures which were pinned (n=8), immediately revised radiological instability (n=2), wound dehiscence treated with a flap (n=1), secondary fusion (n=4). There were no cases of infection. There were six failures (12%) leading to implant removal for loosening (n=3), pain (n=2), instability (n=1) and revision arthrodesis (n=4) or new arthroplasty (n=2). The 44 remaining cases were analyzed: AOFAS score improved from 40/100 to 73/100 at last follow-up. Joint motion was 24° preoperatively and 20.5° postoperatively (dorsal flexion −1° to +6°, plantar flexion 25° to 14.5°).

Radiographically five prostheses were unstable with potential loosening (3 tibial and 2 talar components), one presented varus misalignment, and the others were considered correct. Moderate to severe intra-articular osteophytes were noted in 11 ankles. Three presented an undetermined defect image in the tibia.

Discussion: Indications for total ankle arthroplasty are exceptional and different from total prostheses for the knee or hip joints. Patients are young subjects with stiff, misaligned, unstable ankles, generally resulting from traumatic injury. Surgery is a challenge and requires several complementary procedures. Failure rate is higher than for the knee or the hip but mid-term results are encouraging. Further follow-up is needed for long-term confirmation.


Joseph-Guy ASENCIO Christian LEONARDI Moïse M’BAYA KALOMBO

Purpose of the study: THe peritalar joints are centered around the talus. They are stabilized by powerful ligaments and oriented along precise alignments. Osteoarthritis of the ankle joint can result from architectural anomalies of the peritalar joints which can be corrected with appropriate surgery. Errors in assessing these disorders is often the cause of failure and consequently the poor reputation of ankle prostheses. This emphasizes the importance of the clinical and radiological preparation. The Méary view with comparative films if possible, enables accurate analysis of the alignments and bone relations as well as the different anomalies of the peritalar joints.

Material and methods: Our experience with more than 500 ankle prostheses implanted since 1989 has led to sometimes proposing complementary corrective procedures before the arthroplasty. Here we present 62 cases of AES total ankle arthroplasty (37 men and 25 women, mean age 55 years) with seven years follow-up. Several types of osteotomies were used: fibular, tibial, malleolar, calcaneal. These osteotomies were sometimes associated or combined with other procedures for ligament plasty fo example.

Results: The overall score was based on the AFCP 100 point functional scale. The score improved from 31.2 on average preoperatively to 78.8 postoperatively. Complications were: involuntary intraoperative fracture, wound healing disorder, reflex dystrophy, nonunion, prosthetic loosening.

Conclusion: Quality Méary views enable an adapted study of the peritalar disorders and the causes of the tibiotarsal osteoarthritic degradation in order to establish a well-adapted surgical plan with the goal of re-establishing normal anatomy. Favorable outcome and thus be expected for ankle prostheses. The indication for arthroplasty can thus be discussed for difficult cases to date treated by arthrodesis.


Grégory SORRIAUX Thierry JUDET Philippe PIRIOU

Purpose of the study: The aim of this study was to analyze the mechanical function of the ankle after implantation of a total ankle arthroplasty. Gait analysis included kinematic and dynamic parameters of the lower limbs before and after prosthesis implantation in comparison with ankle fusion.

Material and methods: This prospective non-randomized study included three cohorts of patients. The first cohort included 12 patients presenting osteoarthritic lesions of the ankle requiring total ankle arthroplasty; these 12 patients were reviewed six months postoperatively and for six of them twelve months postoperatively. The second cohort was composed of 12 patients reviewed twelve months after tibiotalar arthrodesis. The third cohort was composed of 12 healthy volunteers who participated in the same study protocol. The gait analysis was conducted with the Motion Analysis optoelectronic system. Parameters recorded were: self-selected speed, fastest speed, stride rate, step length, stride symmetry and length, symmetry of floor contact, and symmetry of toe lift-off. In addition, patients participated in specific tests to step over an obstacle and go up and down stairs.

Results: Gail was slower an asymmetrical in patients with ankle fusion. Fusion enabled good recovery of gait speed but at the cost of imbalanced weight-bearing times and asymmetrical toe lift-off. Total ankle arthrodesis provided little improvement in gait speed but enabled progressive and persistent recovery of symmetrical gait.

Discussion: It is well established that an ankle prosthesis improved joint force and motion in comparison with the osteoarthritic ankle. Fusion provides good clinical and kinetic results but at the const of compensation by the joints above and below the ankle. Few studies have examined gait symmetry which in our opinion would be a good criterion for evaluating the quality of gait.

Conclusion: The raw data obtained in this study demonstrate that patients with an osteoarthritic or fused ankle can recover gait speed but that they retain a limp. Total ankle arthroplasty enables a more balanced fluid and symmetrical gait which is much more comfortable for the patient.


Stéphanie VALENTIN Laurent GALOIS Yves STIGLITZ Frank WEIN Valentine ANNE Didier MAINARD

Purpose of the study: Static metatarsalgia is a common complaint in podology surgery. Most cases are related to the great toe, but in certain cases, isolated metatarsal disharmony, without hallux vlgus, can be observed. We report 45 such cases.

Material and methods: This was a retrospective analysis of isolated metatarsal disharmony observed in patients who underwent metatarsal surgery between 1986 and 2003. There were 36 women and 9 men, mean age 49 years. Three subgroups were distinguished: posttraumatic disharmony, isolated disharmony of the second ray, iatrogenic disharmony. Conditions related to rheumatoid disease, aseptic osteonecrosis of the metatarsal heads, and rear foot disorders were excluded. Surgical treatment was osteotomy of the base of the metatarsal for 24 patients, and Weil’s osteotomy for 21. Clinical and radiological assessment used the Kitaoko and Maestro criteria.

Results: Mean preoperative score was 38 (range 21–58). Mean gain one year after osteotomy was 35 points. The score was 76 after osteotomy of the metatarsal base and 79 after Weil osteotomy. The less favorable results were observed in the group of posttraumatic metatarsalgias. Outcom was less satisfactory in the male population where residual metatarsalgia was noted in 75%. Reflex dystrophy occurred in 15% of the patients who had multiple osteotomies. Radiographically, The SM4 line was centered with progressive geometry in 50%.

Discussion: While the short-term results obtained with these two surgical methods were similar, osteotomy of the metatarsal base offers better long-term outcome. The osteotomy improved the functional score, even without improvement of radiological criteria. Initial treatment of metatarsal fractures should attempt to restore correct alignment of the metatarsals because of the poor results obtained with corrective osteotomy for posttraumatic misalignment.

Conclusion: When metatarsal disharmony is symptomatic, we propose osteotomy of the base of the metatarsals for the median rays in order to avoid transfer metatarsalgia. Complementary osteotomy of the fifth metatarsal is not always necessary.


Sylvain GADEYNE Jean-Luc BESSE Sophie GALAND-DESMÉ Jean-Luc LERAT Bernard MOYEN

Purpose of the study: The pathophysiology of reflex dystrophy or type I complex regional pain syndrome remains poorly understood, but the cost is considerable in terms of public health expenditures both for programmed and emergency orthopedic surgery. We present a historical cohort assessed to evaluate the usefulness of vitamin C for the prevention of reflex dystrophy in programmed foot and ankle surgery.

Material and methods: The study included two groups of patients treated in two successive periods: July 2002 to June 2003 and July 2003 to June 2004. All patients underwent foot and ankle surgery performed by the same senior surgeon. Diabetic feet were excluded. The first group (185 feet, 177 patients) was not given any particular preventive treatment. The second group (235 feet, 215 patients) was given one gram vitamin C for 45 days. The diagnosis of reflex dystrophy was retained on the basis of clinical and radiological arguments noted at follow-up visits with the operator. Several factors were studied: gender, age, type of disease condition, history of reflex dystrophy, psychological context, duration of tourniquet, cast immobilization.

Results: Reflex dystrophy occurred in 18 feet in group

1 (9.6%) and in 4 (1.7%) in group 2. The difference was significant. Presence of a history of dystrophy was significantly associated with development of dystrophy (RR=10.4). A psychological context appeared to increase the risk of dystrophy (RR 2.6) but did not reach significance. There was no statistical relationship with age, gender, duration of tourniquet, type of disease condition, or surgical procedure performed.

Discussion: Vitamin C has been found to be effective in the prevention of reflex dystrophy after wrist fractures. Data in the literature is scarce on dystrophy of the foot and ankle. Our study provided objective evidence of the usefulness of vitamin C for the prevention of reflex dystrophy in foot and ankle surgery patients, a complication frequently observed in our control group (9.6%). The psychological context and history of dystrophy increase the risk of dystrophy.

Conclusion: Vitamin C is associated with a lower risk of reflex dystrophy in the postoperative period after foot and ankle surgery. We advocate preventive treatment with vitamin C.


Yann-Philippe CHARLES Michel MARCOUL Jean-François BOURGIN Amélie MARCOUL Alain DIMÉGLIO

Purpose of the study: Idiopathic scoliosis is a tridimensional deformation of the spine. For an overall description of the deformation, it is important to determine the exact deformation in each dimension to identify the topography and amplitude of the curvatures as well as the sagittal balance and vertebral rotation. Scoliosis is actually a deformation of the thoracic cage, which could be considered as its fourth dimension. The purpose of this study was to measure thoracic parameters, particularly thoracic volume, as a function of spinal curvature and growth in children. The goal was to better describe the deformation and difference in comparison with the normal population.

Material and methods: In this prospective study, The Orten (Lyon) optical acquisition system was used to fashion a corset for 130 patients (110 girls, 20 boys, aged 4–16 years) with idiopathic scoliosis. The volume, circumference, anteroposterior and frontal diameters as well as the lengths T1–T12 and sternum were noted. These data were confronted with the clinical growth parameters: age, height in the upright and sitting position, body length, body weight, body mass index. Thoracic curvatures were measured using the Cobb system (15–45°). The vertebral rotation component was noted. In order to compare these pathological data with those observed in a normal population, the same optical acquisition protocol was performed in a control group of 65 girls and 61 boys free of thoracic deformation.

Results: There was no significant difference in thoracic volume relative to the different growth parameters between the control group and the scoliosis group (Wilcoxon test: p=0.056). There was a correlation between thoracic volume (3–17 dm3) and age: boys r=0.75 and girls r=0.74. At about 4 years, thoracic volume was on average 33% of volume attained at puberty and at 10 years, 55%. These reference points were true for girls and for boys in the scoliosis and the control groups. The following relationships between thoracic measurements and sitting height were found to remain unchanged during growth: frontal diameter is about 30% of sitting height; anteroposterior diameter is equal to the length of the sternum and is about 20% of sitting height.

Discussion and conclusion: The Orton optical acquisition system can be used to describe quantitatively the deformation of the thoracic cage caused by scoliosis. There was however no significant difference in thoracic volume between the normal controls and the scoliosis children with a curvature < 45°. Major scoliosis leads to deformation of the vertebral bodies and thus the thorax. This fourth dimension of the deformation should be taken into consideration when establishing the treatment by corset or surgery. This study described the thoracic parameters observed during growth in children with mild to moderate scoliosis. A later study on more severe forms will complete these data and enable an objective assessment of the thoracic deformation.


Pedro DOMÉNECH Pedro GUTIERREZ Jesus BURGOS Gabriel PIZA Eduardo HEVIA-OLAVIDE Javier ROCA Joaquin FENOLLOSA

Purpose of the study: Fixing the pedicles can be difficult to achieve during surgical treatment of scoliosis involving the thoracic spine because of the vertebral rotation raising the risk of neurological and vascular disorders. Use of extrapedicular thoracic screws has been proposed for more adapted and safe fixation. No clinical data has been published concerning the safety of these screws.

Material and methods: This multicentric retrospective clinical and radiological study included 467 thoracic screws in 34 patients operated for scoliosis. Neurophysiological monitoring was used for all procedures. Screws were positioned free hand without radioscopic control. Pedicular screws were inserted in T10, T11, T12. Extra-pedicular screws were inserted for thoracic vertebrae above T10 to T4. Correction was achieved with rods bent in situ. The purpose of this study was to evaluate the position of the thoracic screws within the vertebral body and in relation to the great vessels and the cord. The position of the screws in the thoracic spine was studied by two independent observers reading multiple thin-slice CT images. The observers noted malposition as: 1) penetration into the canal more than 2 mm, 2) less than 1 cm hold in the vertebral body, 3) screw protrusion more than 2 mm beyond the vertebral cortical.

Results: Screw malposition was observed for 9 of 161 pedicular screws (5.4%) and for 21 of 306 (6.8%) thoracic screws. None of the screw malpositions had a clinical expression. There was one episode of thoracic effusion associated with thoracoplasty. Two patients required revision (one for poor indication and one for disincarceration). There were no postoperative deep infections. Three cases of intercostals neuralgia subsided within three months.

Conclusion: Insertion of thoracic screws for fixation and correction is a useful technique with few complications. It enables better 3D correction and better control of the deformation. Screw malposition in this series was similar to that observed with classical pedicular techniques. There was no major complication associated with thoracic screws.


Yann GLARD Franck LAUNAY Elke VIEHWEGER Jean-Luc JOUVE Gérard BOLLINI

Purpose of the study: In spina bifida, independently of limb paralysis, spinal deformation can cause significant static disorders (scoliosis, kyphosis, or hyperlordosis) which in turn cause significant disability. These deformations generally develop during growth. We wanted to determine the predictive value of a clinical classification based on the neurological examination at five years for risk of spinal deformation.

Material: This retrospective study included 163 patients. Groups were defined on the basis of motor function determined by the neurological examination at five years: group I: L5 or below (all patients in this group had motor deficit leaving at least one L5 segment intact); group II: L3–L4; group III: L1–L2; group IV: T12 and above.

Results: Results showed that group I was a factor predictive of an absence of future spinal deformation. Groups III and IV were predictive of presence of a future spinal deformation. Group IV was predictive of future kyphosis.

Discussion: It is well known that the higher the neurological lesion in spina bifida, the higher the rate of spinal deformation. No work has however set the limits nor provided predictive rules useful in clinical practice. Our work demonstrated that this classification based on the motor function established by neurological examination at five years can predict which children have a risk of developing a spinal deformation and thus enabling early detection and treatment.

Conclusion: This neurological classification can be used as a clinical tool for the prognostic evaluation of spina bifida.


Jean-Marie GENNARI Jean-Marc GUILLAUME Pierre CHRESTIAN Maurice BERGOIN

Purpose of the study: The surgical technique for thoracolumbar scoliosis and T11-L3 lumbar scoliosis with a lumbosacral counter curvature (neutral L4) does not raise any particular problem in terms of the length of the instrumentation and the choice of the vertebral bodies to include in the fusion. The strategy is however more difficult to establish when the iliolumbar angle is closed and L4 is included in the curvature.

Material and methods: We report 11 cases of type II scoliosis, all in girls aged 15.5 years on average (range 12–18 years). These girls presented an imbalanced trunk with lumbar asymmetry. Mean lumbar curvature was 51° (range 41–72°), and, for patients with a double curvature, the mean thoracic counter curvature was 28° (range 21–45°). Lateral lumbar displacement was 4.2 cm (3–4.9 cm), and in double curvatures the thoracic displacement was 3.1 cm (1.7–4.2 cm). Mean lumbar lordosis was −41° (range −38° to −46°). Mean thoracic kyphosis was +13° (range −2° to +22°). Anterior instrumentation was used for all curvatures. For six patients, five levels, from T11 to L3 were instrumented and in five patients, four levels from T12 to L3. For the double scoliosis cases, in situ rod bending was necessary to balance the lumbar curvature with the thoracic curvature.

Results: Mean follow-up was 42 months (range 14–79). One revision was required for rupture of a corporeal screw with L4–L5 nonunion. Trunk imbalance was corrected in all patients. The iliolumbar angle was opened with a mean L3–L4 inclination of 11° (range 0–18°). Mean Cobb angle was 22° in the lumbar region (range 17–30°). For the double curvatures, the mean residual thoracic curvature was 27.6° (range 17–44°). Mean residual lateral displacement was 0.2 cm in the lumbar region (range 0–0.3 cm) and 0.8 cm (range 0.3–2.2 cm) in the thoracic region. Mean thoracic kyphosis was 13° (range +10–25°). Mean lumbar lordosis was −51° (range −49° to +44°).

Discussion: In the literature, a posterior approach has been proposed for curvatures with a closed iliolumbar angle and inclusion of L4. The assembly includes L4 and often L5, extending as high as T5–T6 in the cases with double curvatures. We have chosen a completely different strategy and propose short anterior instrumentation. The spinal balance obtained appears to be as good with a better functional result due to the preservation of spinal motion and posterior muscle function. Longer follow-up will be necessary to assess the effect on the discs above and below the fusion.


Monica URSEI Jérôme SALES DE GAUZY Gorge KNORR Aziz ABID Phillipe DARODES Jean-Philippe CAHUZAC

Purpose of the study: Surgical strategies for high-grade spondylolisthesis are controversial. The main subject of debate concerns the indications for reduction or in situ fusion. We present mid-term results obtained in a series of patients with high-grade spondylolisthesis treated by posterior reduction and fusion.

Material and methods: Sixteen patient who had undergone surgery for spondylolisthesis of the superior isthmus > 50% were reviewed. Mean age was 12 years (range 9–16 years). Preoperatively, all patients were symptomatic with lumbalgia, truncated radicular pain, and gait anomalies. Surgical treatment consisted in a single posterior approach, L5 laminectomy, curettage of the L5-S1 disc combined with excision of the S1 dome, L4-S1 instrumented reduction, anterior L5-S1 and posterolateral L4S1 arthrodesis. Postoperative immobilization was achieved with a resin lumbar cast with crural stabilization for three months then a lumbar orthesis for three months. Clinical and radiographic outcome was assessed at 44 months on average (range 10–260 months).

Results: Clinically, 14 patients were pain free and had resumed their former activities. One patient complained of intermittent pain. No improvement was observed in one patient. Radiographic results were: displacement 78% (range 52–100%) preoperatively and 30% (8–95%) at last follow-up. The L5S1 displacement angle was 14° kyphosis (range 8–30°) preoperatively and 9° lordosis (range 3–12°) at last follow-up excepting one case with complications. The pelvic incidence was 85° (range 65–100°) preoperatively and 74° (range 50–90°) at last follow-up. Complications: There was one early infection treated by wash-out debridement and antibiotics without removing implants. Disassembly of the implanted material in one patient with a poor clinical result led to complete recurrence and lumbosacral kyphosis. Sacral screw fracture was diagnosed in six patients on average one year after surgery but without any progression or recurrence of the displacement. There were no neurological complications.

Discussion and conclusion: Posterior reduction enables restoration of a good sagittal balance. More than the reduction, it is particularly important to restore the lumbosacral junction in a lordosis position to guarantee long-term stability. This technique is a difficult surgical challenge and raises the risk of recurrence and potential neurological complications.


Raphaël VIALLE Jean-Paul PADOVANI Pierre RIGAULT Christophe GLORION

Purpose of the study: Appropriate surgical treatment for severe lumbosacral spondylolisthesis remains a subject of controversy. Correction of the anterior displacement of L5 and the lumbosacral kyphosis is considered dangerous because of the risk of neurological complications. We present a consecutive series of 40 patients who were treated with the Padovani double plate method for high-grade spondylolisthesis. The long-term outcome was assessed. The reasons for abandoning this method were also discussed.

Material and methods The files of 40 patients (15 boys and 25 girls, aged 8–20 years) underwent surgery in our center from 1979 to 1996. All presented anterior displacement of L5 greater than 50%. After release of the L5 and S1 roots via a posterior approach and insertion posteriorly to anteriorly of two anchors in the S1 body, correction of the L5 displacement was achieved via a transperitoneal anterior approach using a plate applied to the anterior surface of L5 and progressively bolted to the S1 anchors. Clinical and radiological outcome was assessed. Spineview was used for angle measurements. The Beaujon and Japanese Ortopaedic Association scores were used for the clinical assessment.

Results: Lumbosacral fusion was achieved in all patients with complete correction of the L5 displacement in 38. A postoperative radicular deficit was noted in twelve patients and resolved completely in ten. Six patients experienced progressive destabilization of the L4–L5 level. Deep infections in contact with implanted material were noted in five patients. At 18 years mean follow-up, 35 patients are symptom free.

Discussion: This technique enables excellent correction of the L5 displacement and an excellent rate of fusion. The method is particularly challenging technically and the rate of complications is high. Reduction of the displacement appears to be associated with numerous radicular deficits, even after prior release. The plate which was rather large for the youngest patients led to lesions of the L4–L5 disc and destabilization of the suprajacent levels.

Conclusion: Although this technique enables optimal and definitive correction of the lumbosacral deformation, the high rate of complications has led us to change our strategy for the treatment of high-grade lumbosacral spondylolisthesis.


Raphaël VIALLE Pierre MARY Olivier DRAIN Philippe WICART Nejib KHOURI Charles COURT

Purpose of the study: The posterior paraspinal approach to the lumbar spine was initially described and promoted by Wiltse for posterolateral arthrodesis of the lumbosacral junction in patients with spondylolisthesis. Despite technical improvements proposed by Wiltse, the muscular cleavage is still poorly localized in the sacrospinalis muscle. The purpose of this work was to provide a more accurate anatomic description of this spinal approach and to describe anatomic landmarks to facilitate execution of the procedure.

Material and methods: Fifty anatomic specimens were dissected (27 male and 23 female cadavers); 33 had been embalmed. The anatomy study used a bilateral approach to the spine. The exact anatomic localization of the muscle cleavage was noted. Measures were taken in relation to the mid line of the L4 spinatus process.

Results: In all specimens, the muscle cleavage lay between the multifidus and longissimus heads of the sacrospinalis muscle. A fibrous partition was noted in 88 of the 100 specimens. The mean distance from the mid line to the cleavage line was 4.04 cm (range 2.4–7.0 cm). The surface of the sacrospinalis muscle presented fine perforating arteries and veins in all specimens, directly in line with the cleavage plane. In 12 cases, a major posterior sensorial branch of the L3 nerve running to the skin was identified in the cranial portion of the approach.

Discussion: The muscle cleavage plane appears to be easy to localize for the paraspinal approach to the lumbosacral junction. Opening the aponeurosis of the latissimus dorsi near the mid line enables visualization of the perforating vessels in line with the anatomic cleavage plane of the sacrospinalis muscle. In our experience, this plane is situated on average 4 cm from the mid line. Hemostasis of these vessels is acceptable since the sacrospinalis muscle has a rich supply of anastomosed vessels. Care must be taken to avoid injury to the posterior sensorial branch of the L3 nerve which runs along the plane of the muscle cleavage.

Conclusion: In our opinion, this minimally hemorrhagic approach is perfectly adapted to non-instrumented fusion of the lumbosacral junction, particularly for spondylolisthesis in children and adults. Precise knowledge of the anatomy of this approach is a necessary prerequisite for successful execution.


Georges KOURÉAS Thierry ODENT Céline CADILHAC Georges FINIDORI Jean-Paul PADOVANI Christophe GLORION

Purpose of the study: Determine the prevalence and course of spinal deformations in Willi-Prader syndrome and assess the effect of treatment with growth hormone. Analyze outcome after conservative and surgical treatments.

Material and methods: We reviewed the files of 51 patients with Willi-Prader syndrome proven genetically. Spinal deformations were classed according to the SRS system. Body mass index (BMI) was determined and correlated with age and administration of growth hormone. Statistical analysis used the coefficient of correlation and the chi-square test to search for correlations between qualitative variables.

Results: There were 37 girls and 24 boys, mean age at last follow-up 10.7±6.7 years. The prevalence of scoliosis was 52% and varied according to genotype.

The prevalence of scoliosis deformations was higher in patients aged over ten years (p< 0.01). The prevalence of scoliosis was greater in female patients. Patients with BMI< 25 had a significantly lower risk of scoliosis. Treatment with growth hormone was associated with a significant decrease in risk of scoliosis. Among scoliosis patients, ten had a main curvature < 15° and were monitored. Eleven had a curvature > 15° (31±11°) and were treated with a corset. Five had a curvature > 50° and trunk imbalance and were treated surgically. Four of these patients developed serious complications.

Discussion: Scoliosis deformation is frequent in Willi-Prader syndrome. Weight control is very important and BMI should be maintained below 25 to limit the risk of scoliosis. Treatment with growth hormone helps limit BMI and thus the risk of scoliosis. For major deformations, surgical treatment is indicated but at the risk of serious postoperative complications.


Frédéric SAILHAN Franck CHOTEL Aygulph CHUSTA Amandine SAVET Thomas HUGUET Eric VIGUIER Pierre BRAILLON Jérôme BERARD

Purpose of the study: We conducted an experimental study of the effects of rh-BMP-7 on healing rate in the tibia of the immature rabbit exposed to bone distraction. As seen in previous models using bone stock loss or lumbar fusion, we hypothesized that rh-BMP-7 accelerates osteogenesis of the distracted segment.

Material and methods: Twenty-eight immature male New Zealand rabbits weighing 2 to 3 kg were randomly selected from a homogeneous population. Two groups of 14 rabbits were constituted by random selection: the control group (group I) and the BMP group (group II). An Orthofix M-103 external fixator was installed on the left tibia in all rabbits before performing a mid-shaft osteotomy. 70 g rh-BMP-7 was applied to the osteotomy surfaces in group II animals. After a postoperative latency period of 7 days, bone distraction was instituted at the rate of 0.5 mm/12 hr for 21 days in all animals. Radiographic qualitative grading, ultrasonography, and bone mineral density measurements on the callus were performed each week on each animal from the second week to sacrifice. After sacrifice, the distracted callus was removed and embedded in resin for histomorpho-metric analysis without decalcification.

Results: Two animals from each group were excluded from the analysis because of a fracture on the pin line of the operated tibia. There were no wound or pin track infections. The radiographic grade noted in group I was constantly greater than in group II. Bone mineral content was significantly higher in group I animals compared with group II. The ultrasound examination of the callus revealed more rapid distraction gap filling in group I than group II. An liquid-filled cyst was noted early in 92% of the rabbits in group II, which retarded osteogenesis. This type of cyst was not observed in any of the group I animals. At the time of sacrifice, the ultrasound and bone density measurements tended toward similar values in the two groups, the results for group II catching up with those for group I. This trend was concomitant with resolution of the cysts within the callus in group II animals. The histological examination demonstrated earlier osteogenesis and remodeling in group I animals.

Discussion: Early formation of cysts would be the only factor causing late maturation of the callus in group II. The fact that the results tended toward similar values for the ultrasound and bone density studies late in the study (when the cysts were being resorbed) favors this hypothesis. Interposing rh-BMP-7 in solid form between the osteotomy surfaces may have inhibited the formation of the primary callus and caused an inflammatory reaction with cyst formation. The rh-BMP-7 may have been applied to early or may in itself had a negative effect, which might explain the absence of the expected acceleration of healing.

Conclusion: Early local application of 70 g rh-BMP-7 on osteotomy section surfaces in a rabbit model of tibial distraction did not lead to expected accelerated healing rate. The application of this compound after formation of a primary callus or in another formulation (liquid) might avoid the development of cysts within the callus and allow the active substance to play is potential role as an accelerator of bone healing.


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Georges FINIDORI Jean-Paul PADOVANI Christophe GLORION

Purpose of the study: We noted that four postoperative compartment syndromes observed in our department occurred in short stature patients with micromely secondary to chondrodysplasia. This complication occurred in young subjects with significant muscular development (two with intensive sports practice) whose muscle hypertrophy appeared exaggerated by the short length of the limbs.

Material and methods: The first case concerned a young man with pycnodysostosis who developed a tibial compartment syndrome after prolonged ventral decubitus subsequent to spinal surgery. No surgical procedure had been performed on the lower limb. The complication was probably triggered by simple compression of the proximal portion of the limb leading to elevated venous pressure and rapid self-aggravating muscular atrophy in a small aponeurotic compartment. The second case was a female patient with metaphyseal dysplasia who during adolescence had undergone corrective bilateral tibial osteotomy to align the lower limbs. Preventive aponeurotomy had been performed which left on one side a disgraceful muscle herniation. Aponeurotic plasty had been performed in adulthood to reconstitute the tibial compartment. A compartment syndrome developed in the immediate postoperative period. The third case was a young adult with hypochondroplasia who developed bilateral crural compartment syndrome 24 hours after femoral osteotomy with implantation of an external fixator for lower limb lengthening.

Results: Sequelae were observed in only one of these four cases of compartment syndrome (patient n° 1). Extensive necrosis of the tibialis anterior was observed due to late diagnosis, leading to legal implications and a court suit. Emergency treatment was given in the three other cases and no sequelae were observed.

Discussion: These patients with chondrodysplasia and micromely appeared to be predisposed to postoperative compartment syndrome because of the relative muscle hypertrophy and the narrow muscle compartments. The risk of this complication in small stature patients warrants the use of preventive aponeurotomy during orthopedic procedures involving the limbs and implies rigorous postoperative surveillance for early detection. Systematic aponeurotomies should be extended over the entire length of the muscle compartment involved in order to achieve effective decompression and avoid disgraceful localized muscle herniation.


Dimitri POPKOV Vladimir SHEVTSOV Arnold POPKOV

Purpose of the study: A population of 154 patients was studied to determine the advantages of continuous lengthening for congenital lower limb length discrepancy (LLLD).

Material and methods: In a first series, we analyzed 80 progressive lengthenings using the standard rhythm (1 mm daily, 4 lenghtenings per day). In a second series (74 lengthenings) a high-frequency rhythm was used (1 mm daily, 60 lengthenings per day). Mean patient age was 10.3 years. Bone regeneration was not stimulated (either by extemporaneous compression or stable elastic centromedullary nailing) in this population. The automatic lengthening fixator was composed of the two standard pieces of the Ilizarov system and complementary blocks with self-propelled traction rods. Besides simplifying the lengthening procedure, these rods allowed high-frequency correction of associated deformities.

Results: Femoral gain was 52 mm on average. For the tibia, the gain was 48 mm on average. For ordinary monosegmentary lengthenings, the healing index was 27.6 d/cm for the femur and 36.0 d/cm for the tibia. For multisegmentary lengthenings with the standard rhythm, the overall healing index was 20.3 d/cm. For patients with high-frequency lengthening, time to healing was shorter. The radiological findings showed the presence of significant bone regeneration which was never inhibited. For monosegmentary lengthenings, the healing index was 22.9 d/cm for the femur and 27.1 d/cm for the tibia. For the multisegmentary high-frequency lengthenings, the overall healing index was 14.7 d/cm. The difference between standard and high-frequency lengthening was significant. In the first series, motion of the adjacent joints was recovered within 12 to 18 months after removal of the fixator. The patients remained in the reclining position during the high-frequency lengthenings and very satisfactory results (complete recovery of joint motion) were obtained 12 months after removing the fixator. In addition, in the second series, there was no impact on the spontaneous growth of the lengthened segments.

Discussion and conclusion: Congenital LLLD is generally more difficult to treat than acquired conditions (Damsin et al., Grill et al., Glorion Ch.). The rate of complications remains significant, particularly concerning healing complications and stiffness in the adjacent joints. Our clinical results prove that high-frequency lengthening provides optimal conditions for tissue regeneration. For children with congenital LLLD, continuous lengthening shortens the delay to healing and avoids stiffness in the adjacent joints.


François-Xavier GUNEPIN Philippe LAINÉ Fabien NUZZACI Frédéric CHAUVIN Hervé LE BEVER François PONS Sylvain RIGAL

Purpose of the study: The different conflicts in ex-You-goslavia left a health care desert. A few medicosurgical units attempted to reconstruct, but their capacities were limited and focused on emergencies. Many patients had to be abandoned. One was a 13-year-old Kosovar boy with active torpid osteomyelitis of the humerus whose family brought him to the French military field hospital in Mitrovica.

Case report: The patient’s general status was mediocre with a hanging left arm which was painful upon mobilization. The skin had a normal aspect. Plain x-rays showed a purulent disintegration of the proximal third of the humerus with 11 cm shortening and loss of bone continuity. The forearm and hand were free of vascular or nervous deficits. Joint testing of the elbow and should was not contributive. The infectious agent was identified (multiple susceptible staphylococcus) and treated. A sequential strategy was undertaken for bone healing. The focus was exposed and stabilized by external fixation with insertion of a spacer and cement. At day 45, an autologous graft was inserted into the induced membrane. The fixator was removed at bone healing (20 days).

Results: The gain was 8 cm. Postoperatively, the patient responded well to double antibiotic therapy. Recovery of joint motion was spectacular for the shoulder but difficult for the elbow. The autologous graft inserted on day 45 was composed of a non-vascularized fibular component completed with grafts harvested from the two anterior iliac crests. At one year follow-up, the infectious focus remains quiescent. The patient can use his arm with no problem. The shoulder motion is subnormal and there is a certain degree of persistent stiffness of the elbow but with no functional complaint.

Discussion: This is a unusual clinical case where the induced membrane technique proposed by Masquelet for osteomyelitis of the humerus was used in an adolescent. The surgical strategy was chosen in part because of the context where microsurgery was not available.

Conclusion: Therapeutic success was achieved with simple reliable techniques. The motivation of the young patient and the efforts of four medicosurgical teams overcame the technical limitations encountered in this field situation. The potential usefulness of the induced membrane technique proposed by Masquelet was demonstrated.


Fabrice DELÉPINE Bernard TAVERNIER Gérard DELÉPINE

Purpose of the study: Epithelioid hemangioendothelioma is considered to be a low-grade malignant sarcoma. Surgical treatment is indicated. The multifocal form of the disease is always located on the right side, involving either a limb or the half-body. Based on a case report and a review of the literature, we discuss the nature of this tumor which may or may not be malignant and examine possible indications for non-mutilating surgery.

Case report: A 17-year-old female consulted in 1996 for lytic lesions involving the right lower limb. Most of the lesions were located on the lower portion of the femoral metaphysic and the upper tibia. The lesions appeared as lytic defects with minimal fracture-like lines on the rims. There was also a defect in the lower tibia shaft and in the foot. All lesions involved the right lower limb. Biopsy material obtained in July 1996 confirmed the diagnosis of grade I epithelioid hemangioendothelioma. Search for skeletal and visceral extension was negative. The classical treatment described in the literature is disarticulation of the hip. Considering the static presentation of the lesions, a conservative treatment was attempted. On July 17, 1996, the patient underwent surgery for curettage, liquid nitrogen cyrotherapy, and cement filling of the tibial and lower femoral defects where there was a risk of fracture. The other lesions were not treated. In 1999, the lesion located in the toe became painful and was treated by cement filling. The patient was discharged with simple surveillance. In 2005, i.e. 102 months after cement filling, this young patient was continuing her university education. No new lesion had developed. All lesions remained stable or regressed, including those which had not been treated.

Discussion: Multifocal epithelioid hemangioendothelioma is generally considered as a sarcoma. Careful examination of the literature (less than 50 cases published) shows many discordant elements. First, the lesions are always hemimelic on the right side, never described on the left, an unusual situation for a malignant process. In addition, the clinical courses described to not lead to death by metastasis. The only progression reported involves possible growth of known lesions. The malignant nature of this disease is thus questionable, even though the histological aspect is exactly the same as monofocal epithelioid hemangioendothelioma which can have a much more aggressive, clearly malignant, course.

Conclusion: Surgeons must not propose first-intention amputation for multifocal epithelioid hemangioendothelioma. Because of the favorable outcome observed in our patient warrants, the malignant nature of this condition is questionable.


José CIFONE Nestor VALLEJOS-MEANA Jorge SUEIRO Daniel VISONA DALLA POZZA

In the United States and other countries, one of the primary causes of medical errors in pediatric patients is the misdiagnosis of hip dysplasia. Thred diagnostic forms are described in children.

We consider that the following diagnostic algorithm should be applied: clinical assessment of both hips at birth, repeated clinical examination once a month to six months, ultrasonography from the sixth week to the fourth month performed by an experienced pediatric operator, in the event of doubt or unavailable programmed controls, radiography of both hips at the fourth month.

We present nine cases of hip dysplasia which illustrate this diagnostic approach.


Frédéric SAILHAN Franck CHOTEL Roger PAROT Jérôme BÉRARD

Purpose of the study: Chondroblastoma is a rare benign cartilage tumor usually observed in secondary ossification centers of long bone in subjects aged 10 to 20 years. We report a multicentric series of 63 cases of chondro-blastoma in children and attempt to identify particular pediatric epidemiological features and identify factors of risk of recurrence.

Material and methods: Clinical data an pre and postoperative imaging were analyzed as well as the histological findings reported by one observer. Files were collected from ten pediatric orthopedic units in France (two in Lyon, three in Paris, Rennes, Strasbourg, Toulouse, Saint-Etienne, Nice). Data were stored in a single database. The series included 35 boys, and 29 girls (sex ratio 1.25=. Mean age at diagnosis was 12 years (18 months to 17 years), 13 years for boys and 11 years for girls. Tumors were located in the epiphysis of the proximal tibia (n=17), the proximal femur (n=16), proximal the humerus (n=16), the distal femur (n=4), tarsal bones (n=4), the distal tibia (n=2), the fibula (n=2), the pelvis (n=1) and the distal radius (n=1). Preoperatively, the Springfield classification was: latent (n=14), active (n=36), aggressive (n=8); five tumors could not be classified. Treatment consisted in curettage-graft (n=40), curettage alone (n=17), curettage and cement filling (n=3), en bloc resection with reconstruction (n=3). Adjuvant alcoholization was used in one case. The histological study searched for an aneurysmal component within the tumor. Four patients were lost to follow-up and 59 patients were analyzed with a mean follow-up of 53 months (range 1–162 months). Statistical tests were applied to the data set to search for factors of risk of recurrence.

Results and discussion: The inaugural syndrome was pain (n=52) or a palpable mass (n=3); the tumor was a fortuitous discovery in one case. Comparison with series including both children and adults revealed certain specific features of this pediatric series. The sex ratio was lower in our series; the distal femur localization, frequent in adults, was rare in children. AT one year, the rate of recurrence was 34% in our series (18/53). Fifteen of the 18 recurrences concerned radiologically active (n=12) or aggressive (n=3) tumors. Recurrence predominated in the tarsal bones (3/3), the proximal humerus (6/14), the proximal femur (5/13) and the proximal tibia (3/14). An aneurysmal component was found in 22% of the recurrent tumors and in 16% of those without recurrence. Statistical tests failed to distinguish any significant correlation with recurrence for age, gender, type of treatment, Springfield grade or localization.

Conclusion: The epidemiological data in this series of pediatric chondroblastoma showed features different from adults. The rate of recurrence was particularly high in this multicentric series (but not statistically significant) for localizations in the tarsal bones or a deep joint (with difficult access such as the shoulder and the hip) or with an aneurysmal component.


Mario LAMPROPULOS

We present the case of an 8-year-old child with congenital multiple arthrogriphosis. The child had never walked and presented 80° fixed knee flexion and hips in a position of hyperrotation which enabled him to sit in a Buddha position. Talipes varus equin with non-reducible supination, compromised by rigid stiff upper limbs was resolved by multiple procedures and immobilization with an external fixator.


Jérôme PAPA Joël REZZOUK Thierry FABRE Alain DURANDEAU

Purpose of the study: Benign tumors of peripheral nerves are exceptional. Schwannomas predominate. Most tumors are revealed by tumefaction or pain over a nerve trajectory. The risk of degeneration is very low. Magnetic resonance imaging is the exploration of choice. The risk of sequelae or recurrence must nevertheless be determined with precision. We reviewed our experience with 93 benign tumors of peripheral nerves to search for factors predictive of prognosis.

Material and methods: This retrospective analysis included patients seen between 1979 and 2004. We collected a series of 89 patients, 41 women and 48 men, mean age 48 years, age range 18–80, with 93 benign tumors. Mean time from symptom onset (pain) to diagnosis was 20 months. The patients consulted for pain (n=78), presence of a mass (n=79) or both (n=66). Percussion produced paresthesia in 54 patients. Pre-operative magnetic resonance imaging was available for 45 patients. The same surgeon performed nerve microsurgery in all patients. A prior procedure had been performed in another institution for 23 patients. The tumors were: schwannoma (n=74), neurofibroma (n=14), plexiform neurofibroma (n=3), angiolipoma (n=1) and intranervous lipoma (n=1). Mean tumor size was 31 mm (range 7–120 mm). Tumors were located in the brachial plexus (n=13), the upper limb (n=29), the trunk (n=1) and the lower limb (n=50). Complete resection was achieved in 83 cases, with removal of a non-stimulatable fascicle in 50 cases and a motor fascicle in

4. Nerve repair was required for 11 cases: 5 by direct suture and 6 with grafts. Resection was impossible for 4 tumors treated by neurolysis, decompressive epineu-rotomy, biopsy and interfascicular dissection.

Results: Mean follow-up was 96 months (range 3–300). Outcome was very good for 42, good for 25, fair for 8 and poor for 5 (all seen secondarily). Nine patients were lost to follow-up. There were no cases of recurrence.

Discussion: Microsurgical procedures are necessary for resection of nerve tumors in order to preserve the fascicles and thus function. Unresectable tumors and secondary grafts yield les satisfactory results, in our series and in the literature. Similarly, the duration of the symptoms and the size of the tumor increase the risk of operative difficulty and sequelae. Despite high-performance imaging techniques, surgery is the only sure way to establish certain diagnosis.


Jean BARTHAS Makram ZRIG Mourad REDJIMI Anne VIDIL

Purpose of the study: Progressive excentration of the femoral head is fequent in the paralytic hip. The result can be dislocation with considerable functional impact even if the subject cannot walk. Once the dislocation becomes permanent,, treatment is difficult. Soft tissue surgery is insufficient. We present our experience with Chiari osteotomy in a series of 28 paralytic hips.

Material and methods: This retrospective analysis included 28 paralytic hips which were operated on from 1974 to 2003. Fourteen patients had cerebral palsy and 14 a cord lesion. Mean age was 18.5 years (range 9–48) at the time of hip surgery. Mean postoperative follow-up was ten years. Prior hip surgery was noted in eleven cases and association with other bone and joint deformities was frequent: scoliosis, oblique pelvis. The Buly classification was noted for patient independence and was ≤ 2 preoperatively for seven patients. Flexion was greater than 80°. Preopeartive excentration was scored according to Reimers: luxation for ten hips and subluxation for 18. Acetabular dysplasia was present in all patients and 19 presented coxa valga. The femoral head was deformed in 14. The objective of the operation was to relieve hip pain and improve hip motion with a good acetabular cover. A chisel was used in all cases for the osteotomy: average 12° ascending cut medially. Associated procedures were: release (n=7), posterior block (n=2), femoral varus osteotomy (n=6), derotation osteotomy (n=6).

Results and discussion: The effect was clearly beneficial in terms of pain relief. There were no stiff hips. No functional degradation was noted and there were no major complications. The Median Reimers index improved from 66% to 19%. Centering was perfect for nine patients and presented residual excentration > 30% for six. There were two cases of femoral head necrosis (on dislocated hips). Seven hips progressed to osteoarthritic degradation and one patient underwent a revision procedure at 14 years for a total hip arthroplasty.

Conclusion: Chiari osteotomy enabled pain relief and improved function in most patients. It stabilized the hip even after dislocation if appropriate procedures are associated. At present however, for dislocated hips, total hip arthroplasty is often proposed. An associated oblique pelvis and scoliosis should be corrected for before surgical treatment of the hip.


François GOUIN Renaud FRIOUX Cécile BAUDRY François YAOUANC Hervé REDON

Purpose of the study: Labrum lesions can be an important source of hip pain. Besides the classical causes, certain morophological anomalies can be associated with labrum lesions. The purpose of this work was to study the contribution of plain x-rays to the search for morphological anomalies of the hip in patients with labrum lesions.

Materials and methods: Twenty-six patients with labrum lesions were included in this study. The plain x-rays protocol included an anteroposterior view of the pelvis in the standing position, a Lequesne oblique view and a lateral view of the neck in the hip flexion position. Patients with severe hip dysplasia (VCA or VCI < 15° or THE > 15°) were excluded. Measurements were made after digitalization using a dedicated software. Measures were: neck-shaft angle, acetabular cover, lateral alpha (neck axis, center of the head, most lateral point of the head sphere), lateral offset, acetabular version. Femoral data in flexion were compared with 20 controls.

Results: Acetabular cover was considered moderately insufficient in five patients (VCA and/or VCE 15–25°). These patients had the same alpha angle as the control population (56°), i.e. no anomaly of the neck-head junction. The 21 patients with non-dysplastic hips exhibited a significantly greater alpha angle (64±9° versus 54.6±8°, p< 0.01) than the controls. All controls presented an alpha angle ≤ 69°. Among the 21 non-dysplastic patients, five presented coxa vara (< 125°), five acetabular retroversion, nine an alpha angle > 69°. In all, 77% of patients presented morphological anomalies of the hip. Among the six «normal» hips using these measures, three presented a pistol-grip aspect which could not be quantified with these measures.

Discussion: This analysis confirms the association between morphological anomalies detectable on plain x-rays and labrum lesions in patients who do no present severely insufficient acetabular coverage. We were unable to detect any difference in femoral offset compared with the control population.

Conclusion: A standard x-ray protocol can, in the majority of cases, detect morphological anomalies of the hip, an important etiological diagnostic element for understanding pathogenic mechanisms.


José CIFONE Nestor VALLEJOS-MEANA Adolfo GRANDAL

Purpose of the study: From 1999 to 2004, 16 patients (25 hips) aged 2–9 years (average 5±3 years) were treated for spastic hips. The patients were diplegic (n=19 hips, 76%) and tetraplegic (n=6 hips, 24%). Pure pyramidal cerebral palsy patients with no history of seizure.

Material and methods: The surgical plan was: femoral osteotomy, periacetabular osteotomy (San Diego), tenotomy of the adductors and psoas, anterior hip reduction as needed. Pain, range of abduction, Reimmer’s index and acetabular index were noted.

Results: In the diplegic patients, outcome was good (70%), fair (23%), poor (7%). In tetraplegic patients, outcome was good (20%), fair (20%), poor (60%). Complications were avascular necrosis (n=1) and decubitus lesions (n=2).


Mario LAMPROPULOS

Purpose of the study: In the spastic quadriplegic non-ambulatory child, hip dislocation with severe adduction is a painful situation compromising perineal hygiene and local care as well as positioning in bed or wheel chair. We describe a method of treatment using Castle’s femoral resection-interposition arthroplasty and an external fixator to prevent proximal migration of the remnant femur.

Description: Resection of the proximal femur with articulated distraction of the hip using an external fixator was performed in eight children (11 hips) with cerebral palsy. All patients (five boys, three girls, mean age 15 years) had painful neurological disorders with chronic hip dislocation incompatible with the sitting position and compromising perineal hygiene.

The operation, described by Castle, consisted in subtrochanteric resection and suture of the quadriceps muscle around the femoral cut. The capsule detacted from the femur was closed around the acetabulum. The abductors were sutured between the shaft and the acetabulum in order to ensure interposition of enough soft tissue. An external fixator (Orthofix®) was installed for 90 days. This method has the advantage of producing the necessary distraction while allowing immediate mobility (hip extension flexion) and good balance in the sitting position as well as better perineal hygiene compared with the preoperative situation.

At six months, there was a clear clinical improvement in terms of pain relief, tolerance to the sitting position, and perineal hygiene with a significant increase in joint motion (flexion, extension, abduction). Proximal migration of the femur was observed in one case after removing the external fixator. There were no cases of recurrent adduction deformity, stiffness or bone hypertrophy.

Conclusion: Proximal resection of the femur with capsular interposition arthroplasty and articulated distraction with an external fixator decreases the pain of the dislocated spastic hip. This method is a reliable salvage alternative for painful hip dislocation in cerebral palsy children. Use of an articulated external fixator for the distraction enables immediate postoperative mobilization and the sitting position in a wheel chair, improving patient comfort compared with the classical Russell also described by Castle.


Alexandre NEHME Robert TROUSDALE Daniel OAKES Ghassan MAALOUF Joseph WEHBE Jean PUGET

Purpose of the study: Acetabular version is a most important parameter for repositioning the acetabular fragment during periacetabular osteotomy. Recently, a few studies have presented a significant number of dysplastic hips with acetabular retroversion. There have not however been any studies devoted specifically to the severity of bilateral acetabular retroversion. The purpose of this work was to determine the incidence of bilateral retroversion in patients undergoing periacetabular osteotomy for dysplasia in order to identify and validate a retroversion index which would be predictive of the degree of retroversion. This index could be added to congenital hip dysplasia classifications to include acetabular version.

Material and methods: The Lequesne lateral view of the hip was obtained in 174 patients (348 hips, 137 women and 37 men, mean age 30 years) undergoing periacetabular osteotomy for symptomatic dysplasia. One hundred ninety-five hips (56%) were operated on and 153 (44%) were considered normal or non-symptomatic and were not operated. The following parameters were noted for each hip: VCE, VCA, HTE, femoral head extrusion, index of acetabular depth, crossing-over, retroversion index. The retroversion index was checked on a bone model of the pelvis which was x-rayed in the neutral position then turned progressively. Statistical data were analyzed with SAS.

Results: Five percent of the operated hips presented neutral version, 53% anteversion and 42% retroversion. Twenty-four percent of the non-operated hips were normal, 22% presented pure retroversion and 54% were dysplastic. All of the measurements were significantly deviated towards dysplasia for operated hips, with the exception of the retroversion index and the VCA.

Discussion: These data validated the retroversion index and confirmed that one out of three dysplastic hips displays retroversion. In addition, it would appear that for dysplastic hips with retroversion, the degree of lateral coverage or the HTE angle determines whether surgery is needed or not and not the degree of retroversion. But as pure retroversion can be symptomatic in itself, and since the majority of these version or cover anomalies can be treated by periacetabular osteotomy, we propose a classification of hip dysplasia included acetabular version.

Conclusion: This classification is designed as an aid for the orthopedic surgeon for reorienting the acetabular fragment to obtain the optimal position.


Mohamed EL JAMRI Philippe CLAVERT Jean NORTH Jean-François KEMPF Jean-Luc KAHN

Purpose of the study: One of the most frequent complications of medial meniscal suture is injury to the saphenous nerve or its branches. The purpose of this study was to ascertain the relations of the medial meniscus with the infrapatellar branches of the saphenous nerve.

Material and methods: Twenty lower limbs were dissected to study the pathways of the saphenous nerve and its branches in relation to different landmarks of the medial meniscus and palpable bony zones. Sixteen measurements were made on each knee held in extension.

Results: The infrapatellar trunk of the saphenous nerve exhibited two terminal branches in all knees dissected. Level of the bifurcation in relation to the joint space varied. Similarly the position of the branches varied greatly in relation to different landmarks. The most frequent configuration was a main trunk situated 8 mm anteriorly to the tubercle of the great adductor and 60 mm from the mid point of the medial border of the patella. The bifurcation into two branches was situated 23 mm above the joint space. The two branches ran obliquely anteriorly and inferiorly forming an angle of 55° on average with a vertical line. The superior branch ran 24 mm behind the anterior meniscal point and 55 mm from the posterior meniscal point; the inferior branch ran 42.6 mm and 38 mm from these two points.

Discussion: Injury to the saphenous nerve or its branches is mainly observed for suturing techniques done medially to laterally. Incidence has reached 38% in certain series. This incidence has declined with the increasingly widespread use of arthroscopy, but saphenous injury still occurs for meniscal repairs using a posteromedial approach. The risk is similar for medially to laterally or laterally to medially sutures. Since there is no safety zone, it would be advisable to prefer an «all medially» technique.

Conclusion: Measurements made on dissection specimens enabled us to delimit three zones of increasing risk for nerve injury. The zone with the highest risk measures 20 mm wide. Its anterior limit is situated behind the most anterior meniscal point and its posterior limit is situated 28 mm from the posterior meniscal point.


Alban PINAROLI Tarik AIT SI SELMI Elvire SERVIEN Philippe NEYRET

Purpose of the study: The purpose of this retrospective study was to analyze clinical datao n pigmented villon-odular synovitis (PVSN) of the knee as well as outcome after treatment in order to define the diagnostic stages, the surgical treatment, and follow-up modalities for this rare benign proliferative disease of the synovial which predominantly affects the knee joint.

Material and methods: Between 1996 and 2004, 28 patients were managed in our department, 13 men and 15 women, diffuse PVNS in 20 and localized PVNS in 8. IN the localized forms, symptoms were similar to those observed in knees with intra-articular foreign bodies or a meniscal lesion (75%) was present for 14 months on average at the first consultation. Mean age at onset of therapeutic management was 40 years (range 20–62). Localized arthroscopic or open resection was performed. For the diffuse forms, symptoms had been present for 15 months on average at the first consultation. Patients sought medical care because of spontaneous hemarthrosis or diffuse knee pain with no specific signs. Mean age at onset of therapeutic management was 38 years (range 15–59). Bony lesions were observed in 20%. Synoviorthesis or surgical synovectomy were performed. Mean follow-up was 97 months (range 12–309). Outcome was analyzed separately for the localized and diffuse forms.

Results: For the localized PVNS, there were no complications after surgical treatment but the relapse rate reached 12.5%. For diffuse PVNS, the cumulative rate of relapse was 50%, recurrence being noted on average 37 months after treatment. A stiff joint developed in 14% after open synovectomy. Surgical treatment was necessary in four cases (total arthroplasty in three) seen late after development of bony lesions; the clinical outcome was good with good gain in flexion.

Discussion: MRI is essential for the topographic diagnosis and to guide surgery. For diffuse PVNS seen at an advanced stage or after several recurrences, adjuvant synoviorthesis can be useful 4 to 8 months after surgery.

Conclusion: Appropriate treatment of PVNS of the knee depends on the presentation but usually involves a surgical procedure. The risk of recurrence for diffuse PVNS warrants annual MRI for four years.


François KELBERINE Philippe CANDONI Philippe BEAUFILS Xavier CASSARD

Purpose of the study: This prospective anatomic study was conducted to analyze meniscal healing after arthroscopic repair.

Material and method: Two preliminary studies (a radio-anatomic study and a comparative arthroscan-arthros-copy study) were conducted to define strict radiological criteria (contiguous slices or spiral acquisition)which could be interpreted by all observers. Sixty-five vertical meniscal lesions were included in the study and divided into four groups according to localization (medial or lateral) and knee stability (stable or associated ligamentoplasty). Arthroscopic repair was performed in all cases. Mean length of the lesions was 20.31±6 mm. Minimum follow-up was six months. The work-up included an arthroscan and the IKDC function score.

Results: The work-up could be interpreted for 62 knees. The overall outcome according to Henning was: 42% complete healing, 31% incomplete, 27% failure. Healing outcome was similar for lesion in a red-red zone (73%) or a red-white zone (70%). The healing surface could be assess for 43 knees: 37% complete healing, 21% partial healing of more than half of the initial tear, 12% partial healing of less than half of the tear, and 12% failure. The analytic results of 17 medial repairs on stable knees yielded: 9 complete, 2 partial, 4 failure, with IKDC (79, 68, 73 points) having no significant influence. For the 24 medial repairs on unstable knees outcome was: complete healing in 10, partial in 6 and a good IKDC score (80.85 points). Functional outcome was poor for the eight failures (67 points). Lateral repairs on 11 stable knees yielded: complete healing in 2 (IKDC 76 points), partial in four (IKDC 94 points) and failure in five (IKDC 82 points). For the ten unstable knees, complete healing was achieved in five and partial healing in five with good patient satisfaction (IKDC 80.70 points).

Conclusion: Methodologically, arthroscan provided a good assessment of healing. The notion of the healing surface appears to be more appropriate than thickness, since partial healing can transform an unstable knee into a stable one. Clinically, in one third of the knees, meniscal healing could not be achieved. This failure was more frequent and less well tolerated for the medial lesions. For the lateral lesions, incomplete healing was more frequent, perhaps in relation to meniscal mobility and the associated ligamentoplasty which apparently protected the meniscal repair. In this series, meniscal healing did not have a significant influence on the functional outcome.


Thomas GRÉGORY Guillaume LORTON Marc-Antoine ROUSSEAU Philippe LANDREAU

Purpose of the study: The aim of this retrospective epidemiological study was to report the complete arthroscopic results concerning meniscus or cartilage injuries for procedures performed to repair the anterior cruciate ligament (ACL). The goal was to search for risk factors and improve patient care.

Material and methods: Between 2000 and 2004, the same operator performed 129 consecutive ligamentoplasties to repair ACL tears. The following preoperative factors were analyzed: body weight, height, type and level of sports activity, laxity, positive pivot test, morphotype, time from accident to surgery. Meniscal lesions were identified and classified according to Trillat. The Beguin and Locker classification was used for cartilage lesions. The Panthéon-Sorbonne statistics laboratory performed the statistical analysis.

Results: Meniscal lesions were found in 53.5% of knees and cartilage lesions in 24.2%. The medial meniscus was involved in 75.4% and the lateral meniscus in 20.3%, both in 4.3%. The injury could be repaired by suture or a conservative procedure for 45%. The medial compartment presented cartilage injury in 51.6% of knees, the patella in 29%, the trochlea in 19.35% and the same percentage for the lateral condyle. The degree of preoperative laxity, the time from accident to surgery and body mass index were statistically correlated with presence of a meniscal injury. Age, the degree of pre-operative laxity and body mass index were statistically correlated with presence of a cartilage injury.

Discussion: Meniscal injuries are frequent in knees with ACL tears. The posterior segment of the medial ligament, which blocks anterior translation of the tibia if the ACL is absent, is predominantly involved. The amount of tibial movement below the femur and stress applied to the knee (particularly related to body mass) favor such lesions. Many lesions will heal spontaneously after surgery. Inversely others are more frequent after a longstanding tear. Cartilage injury is also frequent and occurs often on aging cartilage. The extent of tibial movements and their repetition as well as important stress are factors predictive of such injuries.

Conclusion: Indications for reconstruction of the ACL in the young subject are well identified, less so in the older subject. This study confirms the usefulness of reconstructing the ACL to protect the menisci and joint cartilage. Excessive weight appears to be another important point to take into consideration for the surgical management of these patients.


Ludovico PANARELLA Olivier CHARROIS Nicolas PUJOL Philippe BOISRENOULT

Purpose of the study: The aim of this prospective study was to assess functional outcome one year after meniscal repair and to correlate them with healing as assessed by arthroscan performed systematically at six months. Follow-up was 12 to 28 months.

Material and methods: Forty one meniscal repairs were included (28 medial and 13 lateral menisci). There were 33 longitudinal vertical tears, five horizontal cleavages in young athletes, one hypermobile meniscus and two complex lesions. The meniscal repair was associated with ACL reconstruction in 26 cases. In six cases, meniscal repair was an open procedure, in 34 a medial arthroscopic procedure and in one a combined arthroscopic open technique. 71% of the tears were recent, 29% were chronic. Mean length of the lesion was 21 mm. Physical examinations were performed in all patients at six weeks, and 3, 6, and 12 months. The

IKDC score was established preoperatively and at 6 and 12 months. An arthroscan was obtained at six months.

Results: There were no neurological complications related to the open approach. In three cases, the suture was loose but without subsequent intra-articular loss. There were no infections. Three patients presented recurrent meniscal tears 12 to 26 months postoperatively: secondary meniscectomy in one and a new repair in another. Therapeutic abstention was proposed for the third (a hypermobile meniscus). Mean subjective IKDC score was 67.0 points preoperatively, 73.2 at six months and 83.6 at one year. Moderate pain persisted at one year in four patients. The six-month arthroscan showed complete or incomplete (but greater than 50%) healing of the meniscal surface in 33 cases and less than 50% healing in 8. Radiologically, healing was similar for medial and lateral repairs. The joint surface was normal in all cases on the plain x-ray.

Discussion: AT 12–28 months follow-up, the rate of recurrence was low (3/41), less than in a retrospective review reported by the French Society of Arthroscopy with the same follow-up. The technique has improved.

Conclusion: The one-year functional outcome is good. Complete healing as assessed on the arthroscan does not indicate the functional outcome at this follow-up.


Denis WAAST François YAOUANC Bertrand MELCHIOR Cyril PERRIER Norbert PASSUTI François GOUIN

Purpose of the study: We conducted a prospective randomized study to compare use of macroporous biphasic calcium phosphate ceramic and bone autografts for filling medial open wedge osteotomies of the proximal tibia.

Material and methods: This phase III pragmatic clinical trial was designed for direct patient benefit. Randomization was performed in the operating room after completing the osteotomy. Twenty-six men and 14 women, mean age 51 years (range 19–75 years) were included. A biomaterial implant was used for 22 patients and an autograft for 18. Mean correction was 10 mm (range 6–15). One patient was excluded from the analysis, no patient was lost to follow-up. All patients were reviewed at minimum two years follow-up.

Results: At three months, knees were less painful with less subjective functional impact after filling with an autograft (pain VAS 3.1 versus 2.1 and function VAS 3.4 versus 2.5). These results were more balanced at six months (pain 1.6 versus 1.8 and function 1.8 versus 2.1) and remained stable at one and two years. The IKS knee scores were symmetrical at one at two years for both groups (IKS1 93 versus 86 and IKS2 90 versus 90). Bone healing was achieved within the usual delay. Axial alignment was stable at two years in both groups. There were eleven complications (28%), nine requiring revision: infected hematoma (n=1), intraoperative vascular injury without serious consequences (n=1), loss of correction (n=2), nonunion after filling with biomaterial (n=1), iliac abscess after filling with autograft (n=2) and painful calcification of the iliac region requiring resection (n=1).

Discussion: We observed three factors which can favor mechanical failure after filling with a ceramic material: intraoperative rupture of the lateral hinge, obesity, and excessively early unprepared weight bearing.

Conclusion: Although the difference did not reach significance, the risk of mechanical complications appears greater with macroporous en bloc ceramic filling. This material is less tolerant to comorbid conditions (obesity) and requires very precise technique as well as careful observance of postoperative care (no early weight bearing). Nevertheless, this method does have the advantage of avoiding painful sequelae and complications related to harvesting the iliac graft.


Stéphane VAN DRIESSCHE Stéphane LE MOUEL Catherine RADIER

Purpose of the study: The purpose of this study was to confirm long-term changes in frontal alignment after wedge osteotomy(even for with an «ideal» postoperative wedge angle of 3–6°), that the frontal alignment is correlated with functional degradation and also with femorotibial skeletal torsion.

Material and methods: A non-consecutive retrospective series of 70 patients aged 57.5 on average at surgery for medial open-wedge tibial osteotomy were reviewed at 10–25 years. Goniometry measurements were obtained in the upright position after healing. Tibial and femoral torsion values were measured on the CT scan. Functional outcome at last follow-up was noted good, fair or poor.

Results: Postoperatively 80% percent of the knees presented frontal realignment within the 3–6° range. At last follow-up frontal alignment had changed on average 10° for 40% of knees. The change in frontal alignment resulted from a deterioration of the medial or lateral joint space and in 80% was associated with poor functional outcome. Knees which preserved valgus of 3–6° at last follow-up had statistically better results than the rest of the series. There was a correlation between valgus frontal misalignment and femoral torsion greater than 14° (anteversion) and between varus frontal misalignment and femoral torsion less than 14°. There thus appeared to be a linear correlation between postoperative changes in the correction and femoral torsion.

Conclusion: Good functional outcome of open wedge tibial osteotomy is correlated with stability of the axial correlation over time. Achieving postoperative valgus of 3–6° does not appear to be sufficient for stable axial correction. To achieve long-term preservation of the axial correction, it would be preferable to modulate the postoperative correction according to the degree of femoral torsion.


François KELBERINE Julien CAZAL

Purpose of the study: For medial osteoarthritis with chronic anterior laxity, we propose an original technique combining subtraction osteotomy and extra-articular ligmentoplasty using the lateral quarter of the patellar tendon.

Material and methods: WE report a retrospective review of 29 patients (11 males/18 females) aged 29–51 years treated from May 1996 to October 2002. Time from rupture of the anterior cruciate ligament (ACL) and the operation was 17.5 years (range 13–22 years). These patients had had 52 prior operations (more than one per knee). All presented functional instability, a positive pivot test, and anterior laxity measured at 8 mm on average (range 5–10 mm) on KT1000. Pain in the medial compartment was observed in all patients with osteoarthritis noted grade II in 7, grade III in 18 and grade IV in 4. Radological varus measured 5–15°. Lateral subtraction osteotomy fixed with a plate was performed in combination with a patellar tendon autograft using the lateral quarter of the patellar tendon. Immediate mobilization with complete weight bearing was the rule.

Results: A mean 5–year follow-up (range 18 months to 9 years). According to the IKDC subjective score, 26 patients were satisfied or very satisfied and 22 of them had resumed their sports activities. Instability persisted in one patient and pain in two. Varus was corrected in three patients but the medial degradation progressed. Anterior laxity measured with KT1000 was 1–6 mm (mean 2 mm). The pivot test was positive in one knee, negative in 18 and revealed slight displacement in 10. Excluding the radiological aspect, the overall IKDC score was 2A, 21B, 6C, 1D.

Conclusion: This combined method is particularly interesting for stabilizing chronic ACL instability causing secondary medial degeneration. It treats two conditions with the same approach with an acceptable rate of satisfaction.


Henri ROBERT Jacques BAHUAUD Nicolas KERDILES Norbert PASSUTI Jean-Pierre PUJOL Daniel HARTMAN Marc CAPELLI Philippe HARDY Bruno LOCKER Christophe HULET Henry COUDANE Alexandre ROCHVERGER Jean-Pierre FRANCESCHI

Purpose of the study: Spontaneous repair of lost deep chondral tissue is minimal in the knee joint. A clinical trial of chondrocyte autografts as described by Brittberg and Peterson was undertaken by the Nantes University Hospital and the French Society of Arthroscopy in 1999.

Material and methods: Twenty-eight patients, mean age 28 years, underwent surgery in eight centers. Etiologies were: osteochondritis (n=14), isolated posttraumatic chondorpathy (n=7), chondropathy and full-thickness ACL tear (n=7). All lesions involved the condyles and were deep (ICRS grades 3 and 4). Mean surface area involved after debridement was 490 mm2 (range 150–1000 mm2). Patients were followed three years after the autologous grafting to assess functional outcome. An MRI was obtained at 2–3 years. Thirteen control arthroscopy procedures were performed including eight with biopsy specimens for histology and immunohisto-chemistry studies.

Results: Twenty-six patients were reviewed at more than two years. There were no general complications, three patients presented a partial avulsion of the graft treated by arthroscopy and one underwent arthrolysis at six months. Function improved in all patients except three and pain improved in all. The ICRS score improved from 43 points (range 19–70) to 77 points (range 39–84). Sixteen control MRIs were available and showed that the graft was hypertrophic in eleven cases, on level in four, and insufficient in one. Marginal integration was good in 11 cases and partial in five. Subchondral integration was complete in ten cases and mediocre in six. The arthroscopic score was nearly normal (score 8–11) in eight cases and abnormal in five (score 4–7). The histological class according to Knutsen (hyaline richness) was: one in group 1 (> 60%), three in group 2 (> 40%), four in group 3 (< 40%) and one in group 4 (bony or fibrous tissue). Function score (r=0.78 and MRI score (r=0.76) were correlated with arthroscopic sores. There was no correlation with the histological results.

Discussion: Clinical outcome was improved in more than 80% of cases, similar to results reported for histological series. The arthroscopic and histological results were equivalent to those reported by Knutsen but inferior to those reported by Bentley or Peterson.


Philippe TRICLOT

Purpose of the study: The limitations of conventional polyethylene are well known (osteolysis). New bearing surfaces have been proposed for hip arthroplasty including new-generation polyethylene products.

Material and methods: We compared four bearings including one metal-on-metal and one ceramic-on-ceramic bearing with results not available for analysis at this 4 years 8 month follow-up. The comparative randomized study included 102 first intention total hip arthroplasties comparing a single variable: the bearing. Common elements were: metal-back press-fit cup (Fitmore) and cemented anatomic stem (Emeraude). Variable elements were: alpha Sulène insert + 28 metal head (n=53) versus alpha Dursul insert + 28 metal head (n=49). Clinical outcome was assessed with the Postel-Merle-d’Aubigné score and the Harris score. Radiological outcome was assessed with: wear (EBRA, semiautomatic linear radiographic penetration), cup migration according to EBRA, and radiographic changes in zone 7.

Results: After checking the validity of the files studied, clinical outcome was strictly the same for the two series: wear Sulène polyethylene 0.21 mm; Durasul polyethylene 0.1 mm. Cup migration was: Sulène polyethylene 0.13 mm; Durasul polyethylene 0.08 mm. Modifications of zone 7 were: Sulène polyethylene 17.8%; Durasul polyethylene 6.6%.

Conclusion: With 4 years 8 months follow-up, several elements are in favor of the new-generation polyethylene inserts, confirming theoretical results with mathematical models. This length of follow-up is insufficient to draw formal conclusions concerning in vivo aging.


Esther POTIER Elisabeth FERREIRA Olivier BETTON Alain MEUNIER Laurent SEDEL Hervé PETITE

Purpose of the study: Cell therapy proposes to fill gaps left by bone stock loss using osteocompetent cells (mesenchymatous stem cells, MSC). Preclinical results have been promising but still require improvement particularly concerning stress to the MSC during in vivo implantation. Stress results from sudden transfer i) from oxygen medium (21% O2) to a hypoxic medium (0–5% O2 because O2 diffusion is limited to 200 mm from a blood vessel), ii) a cell support to an osteoconductor support, et iii) a rich medium (fecal calf serum, FCS) to a medium with a limited supply of nutrients, hormones and growth factors diffusing from the environing biological fluids. The purpose of this study was to evaluate in vitro the impact of these different factors on MSC survival.

Material and methods: Human MSC(hMSC) harvested from bone marrow (n= 5 donors) and sheep MSC (sMSC) obtained with a preclinical model (n = 5 animal donors) were exposed for 48 h(hMSC) or 72h (sMSC) to the following transfers: i) rich medium (10% FCS) to poor medium (1% FCS), ii) plastic support to osteo-conductor supports (alumina, calcium carbonate), and iii) oxygen medium (21% O2) to hypoxic medium (6% O2). sMSC were also exposed to prolonged hypoxia (48–120h). Cell death was determined using image analysis after live/dead cell staining.

Results: The results demonstrated that MSC are: i) sensitive to a decrease from 10% to 0% FCS; 14% death of hMSC and 17% death of sMSC), ii) sensitive to transfer onto osteoconductor supports (sMSC on calcium carbonate: 23%), iii) very sensitive to prolonged hypoxia (120h) when combined with decreased FCS (sMSC: 23%; hMSC: 98%). A complementary study on the influence of hypoxia on differentiation properties of surviving sMSC is under way.

Conclusion: If the in vivo results concord with the in vitro results, i.e. if massive cell death is observed 4 days after implantation due to hypoxia, the current transplantation conditions will have to be revisited. Acceleration of neovascularization of in vivo implants which would shorten the period of hypoxia should allow better survival of implanted sMSC.


Marie-Christelle DEGAT Guy DUBREUCQ Alain MEUNIER Latifa DAHRI-CORREIA Hervé PETITE Laurent SEDEL Delphine LOGEART-AVRAMOGLOU

Purpose of the study: Bone morphogenetic proteins (BMPs) are osteoinducing proteins which play a primordial role in bone repair. To obtain optimal mineralization in vivo, high doses of heparin binding growth factor must be used. Studies have demonstrated that functionalized dextranes (FD) present affinity for heparin binding growth factor. We studied the capacity of dextrane derivatives to interact with BMP-2 and potentialize its biological activity in vitro.

Material and methods: Different soluble FD were obtained by random substitution of carbosymethyl (CM), benzylamide (B) and sulfate (Su) groups on native dextrane chains. Gel electrophoresis was used to study the affinity of the anionic FDs for BMP-2. The effect of polymers on osteoinduction activity of BMP-2 was evaluated by histochemistry. ALP (an early marker) synthesized by mypoblasts C2C12 were dosed seven days after injection in presence of BMP-2 associated or not with polymers. IN addition, expression of osteocalcin (late marker) was quantified by RT-PCR.

Results: Electrophoresis demonstrated that DMCB and DMCBSu interacted with BMP-2. These interactions appeared to increase with B level but decreased with Su level. We worked with FD1, a DMCB with a high affinity for BMP-2. The ALP activity was clearly potentialized when BMP-2 was associated with heparin and even better with FD1. Expression of osteocalcin was also amplified with the FD1-BMP-2 association. The influence on the biological activity of BMP-2 of FD, presenting different degrees of substitution, was also tested. Only FDs containing a high concentration of B expressed affinity for BMP-2, potentializing the biological activity of the protein.

Discussion: Dextanes functionalized with a high rate of benzylamide substitution interact with BMP-2 while sulfate substitution limits such interaction. Only FDS which interact with BMP-2 can potentialize the protein’s biological activity in vitro. Two hypotheses can be put forward: i) FD presents BMP-2 to its receptor cell, ii) FD protects BMP-2 from proteolytic degradation or capture by antagonists. The capacity of FD1 to potentialize the biological activity of BMP-2 could be a way of reducing the quantity of growth factor needed for optimal bone repair.


Christophe TROJANI Jean-François MICHIELS Pierre WEISS Majlinda TOPI Pascal BOILEAU George CARLE Nathalie ROCHET

Purpose of the study: The current approach for improving the performance of compact bone substitutes is to seed them with selected mesenchymatous stem cells amplified and differentiated to the osteoblastic line in vitro. We hypothesized that the preservation of all these elements in the bone marrow would be most effective for bone tissue formation.

Material and methods: Subcutaneous and intramuscular implantation in C57BL/6 mice. We developed a new approach for bone tissue engineering based on an extemporaneous incorporation of total bone marrow into an injectable bone substitute (IBS2). IBS2 is a new polymerizable hydrogel associated with beads of calcium phosphate (BCP) which can be used to implant total bone marrow. A subcutaneous and intramuscular implantation model in mice was tested to analyze the feasibility of this type of graft. Total bone marrow cells from C57BL/6 male mice were seeded in IBS (10 million cells per 100 microliters). This implant was injected subcutaneously (dorsal position) and intramuscularly (left hind foot) in C57BL/6 female mice. TRAP activity was measured under optical microscopy on paraffin embedded HES stained slices at 4 and 8 weeks.

Results and discussion: Incorporation of total bone marrow cells in injectable IBS2 produced implants which were rich in mesenchymatous cells, vessels, osteo-clasts, collagen fibers, and osteoid tissue. This demonstrated the great potential of this new approach. In addition, this method is simple and can be performed in the operative room without ex vivo culture. Comparison of this model of extemporaneous cell therapy with a graft of meschymatous cells amplified ex vivo is currently under way.


Elisabeth FERREIRA Esther POTIER Lluis MIR Hervé PETITE Laurent SEDEL

Purpose of the study: Several studies have demonstrated the usefulness of mesenchymatous stem cells (MSC) for cell therapy aimed at favoring bone tissue healing. Bone morphogenesis proteins (BMP) orient MSC towards osteoblastic differentiation. Since they are rapidly degraded in the organism, these proteins require a continuous release system to potentialize their biological activity in a controlled localized manner. We evaluated the usefulness of using the electroporation technique to insert a BMP transgene into the MSC of rats to enable sufficient transient expression of BMP genes to enable satisfactory bone healing. We first developed electroporation conditions for rat MSC and checked cell viability after the electric shock. Secondly, in order to obtain quantitative and/or temporal BMP expression, we tested the influence of different promoters on transcription actvity.

Material and methods: To determine the electroporation parameters, MCS were transfected with the pCMV-LacZ plasmid using two electric impulsions: a series of eight 100 impulsions/μs at high voltage (900-170V/cm) followed or not by a series of eight 12.5 ms low-voltage impulsions (60 V/cm). After determining the electroporation conditions, six plasmids carrying different promoters were electroporated.

Results: The best transfection rate in rat MSC was obtained with a series of 8 impulsions at 1500 V/cm. Before the electrical shock, the suspended rat MSC had to be incubated at ambient temperature to favor cell survival. Proliferation of electroporated cells was comparable to that of non electroporated cells. Surprisingly, addition of low-voltage pulses significantly decreased the efficacy of transfection. In addition, MSC transfected with the promoters GAPDH and beta-actin presented a beta-galactoside activity (at 48 h) superior to that obtained with the pCMV promoter.

Discussion: After optimization of these parameters, we demonstrated that MCS can be effectively transfected by electroporation. The following steps will be to check for long-term expression of beta-galactoside by electroporated MSC, transfection of MSC with plasmids or the BMP-2 gene controlled by these same promoters and monitoring promoter activity as a function of the stage of MSC differentiation.


Jean DUBOUSSET Georges CHARPAK rène DORION François LAVASTE Wafa SKALLI Jacques DEGUISE Gabriel KALIFA Solène FEREY

Purpose of the study: The objective of this work was to achieve a whole-body 3D study of the bone and joint system in the upright position using the lowest radiation dose possible. Radiation doses can be considerable when acquiring 3D images using computed tomographic millimetric sections which in addition are acquired uniquely in the reclining position and thus limited to a specific region.

Material and methods: Using a gas detector which transforms x-ray protons into electrons (G. Charpak) we constructed a device which enables acquisition of high-quality anteroposterior and lateral whole-body radiographic images with exposure to radiation doses 8 to 10-fold less than classical 2D x-rays. A 3D reconstruction of the entire skeleton was obtained from these two initial images.

Results: The 3D reconstructions were validated and compared with those obtained with computed tomography. The results were concordant and revealed least equivalent to if not better reliability. The advantage was to enable study in the functional upright position an to study weight-bearing joints of the lower-limbs, pelvis, and spine. In addition, radiation exposure for the 3D reconstructions was reduced 800 to 1000 times compared with computed tomography. More than 150 examinations have been performed and validated in patients with diverse pathological conditions as well as in normal control adults and children.

Discussion: There is a very wide potential field of application for this technique in orthopedics, both for 3D analysis of joint deformations and their impact on the whole body, and for therapeutic follow-up, particularly after prosthetic or corrective surgery. For example, the horizontal plane which is very difficult to image and represent mentally for spinal surgery can be clearly planned and controlled. This new imaging technique offers perspectives for intraoperative navigation and for bone mineral density measurements. The double-energy methodology enables short-term evaluation of fracture risk due to osteoporosis of the spine and limbs or pelvis.


Didier MAINARD Hélène DUMONT Nathalie PRESLE Louis-Bernard TERLAIN Laurent GALOIS Damien LOEUILLE Patrick NETTER Pascale POTTIE

Purpose of the study: This study was designed to assess the role of leptin in the development of osteoarthritis (OA) by searching for its presence in the synovial fluid (SF), tissues, and cartilage of osteoarthritic joints in humans and by observing the effect of intra-articular injections of leptin in the rat.

Material and methods: The leptin level in SF was measured (ELISA) in twenty patients (ten female, ten male, mean age 70 years). Presence of leptin, TGF beta and IGF1 in cartilage (and osteophytes) was detected by immunohistochemistry after histological evaluation (Mankin). In the rat, leptin was injected into the knee joint at the dose of 30 and 100 μg. After the immunohistological study, proteoglycan synthesis was assessed (S35 integration) as was the expression of leptin, TGF beta1 and IGF1 using RT-PCR.

Results: This study demonstrated for the first time the presence of leptin in synovial fluid (0.6–17.4 and 5.3–28.4 μg in male and female specimens respectively). There was a significant correlation with body mass index. Leptin was over expressed in chondrocytes of osteoarthritic cartilage and was correlated with the histological score (leptin not detecable in normal cartilage). IGF1 and TGF beta1 were expressed in osteoarthritic chondrocytes. The topographic distribution and the intensity of labeling varied with the histological score. There was a strong expression of TGF beta 1 only in osteophytes. In the rat, leptin stimulated anabolic functions of the chondrocyte: maximal effect at 30 μg (medial tibial plateau) and 100 μg (lateral tibial plateau). Leptin over expressed transcripts IGF 1 and TGF beta 1. This effect was confirmed at the protein level.

Discussion: Leptin is an adipocytokin which regulates food intake and energy expenditure at the hypothalamic level. A mechanical mechanism is the primary explanation of osteoarthritis in weight-bearing joints in obese patients. But leptin is also present specifically in non-weight-bearing joints in obese subjects. A biological factor is thus incriminated which might be leptin produced by adipose tissue. Leptin is overexpresssed in the cartilage of the osteoarthritic knee. This is in favor of a role for leptin in the pathogenesis of OA via synthesis of TGF beta 1 and IGF 1. This effect of leptin could explain the relationship between body mass index and the risk factor for osteoarthritis.


Franck VILLARS Samantha DELMOND Alain LERCH Christian REY Igor BÉNÉSIS Laurent POTHUAUD Thierry FABRE

Purpose of the study: The osteoconductive properties of hydroxyapatite surfacing improves the biointegration of orthopedic implants. Current high- and low-temperature resurfacing techniques have several drawbacks, particularly concerning the control of phases. The «low-temperature nanocrystalline apatite resurfacing technique using amorphous phosphate» was developed to avoid this type of inconvenience. The purpose of this study was to examine the biocompatibility of resurfacings produced with this patented technique and to compare biological efficacy with that of the reference technique of plasma torch resurfacing.

Material and methods: The cytocompatibility tests included cell proliferation and attachment tests using human osteoprogenesis cells, and phenotypic characterization of phosphatase alkaline (PAL) and pro-collagen (type I) activity. Biocompatibility studies were performed. Cylinders of natural titanium or titanium resurfaced with the plasma method and the low-temperature method (single layer, bilayer) were implanted in 16 rabbits in condylar and tibial sites. Histological examinations without decalcification were performed one and three months after implantation (n=8 for each time and condition). The implant-quantity of bone in contact ratio was determined by histomorphometry. Scan electron microscopy was used to ascertain the persistence of the resurfacing.

Results: The cell attachment rate of 30–40% confirmed earlier results. The cells grew, and preserved and maintained their differentiation properties (PAL activity at 7, 14 and 21 days). The histological results revealed that all types of resurfacing were well tolerated. HIstomorphometry confirmed the influence of the implantation site on the tissue reaction. One month after implantation, the low-temperature amorphous resurfacing appeared to produce a better result with an optimal ratio for the bilayer in the tibial site and an optimal ratio for the monolayer in the condylar site. The trend was the same three months after implantation, but was less pronounced compared with the plasma torch resurfacing. Paradoxically, the absence of treatment produced a very satisfactory ratio at the condylar level. Scan electron microscopy demonstrated rapid resorption of amorphous resurfacing unlike plasma torch resurfacing with was detectable three months after implantation.

Discussion and conclusion: The different performance levels of bilayer and single-layer resurfacings depending on the implantation site might be explained by the cortical or cancellous nature of the neighboring bone. Low-temperature resurfacing would be more appropriate for implants inserted into cortical bone. In vivo, this resurfacing is resorbed but appears to enable, like the plasma process, the formation of peri-implant bone formation. It offers the advantage of enabling incorporation of compounds of interest (antibiotics, growth factors).


Véronique VIATEAU Geneviève GUILLEMIN Yolande CALANDO Karim OUDINA Laurent SEDEL Didier HANNOUCHE Hervé PETITE

Purpose of the study: The objective of this study was to establish an experimental sheep model for a surgical procedure which has been clinically successful for repairing major loss of bone stock: the Masquelet technique.

Material and methods: A 25 mm bone defect was created in a metatarsal bone then filled with a cement filler. After six weeks, the cement was removed after opening the neoformed pseudosynovial membrane. The cavity was left empty in group 1 (n=6) or filled with a morcelized cancellous autograft harvested from the iliac crests in group 1 (n=6).

Results: The surgery was well tolerated in all animals which were able to used the injured limb the day after the operation. Radiographic images and histological findings 24 weeks after surgery demonstrated that healing had not been achieved in all of the animals in group 1. Inversely, healing was achieved in all animals in group 2 at 24 weeks. Immunohistochemistry of the neoformed pseudosynovial demonstrated :

an abundant vascular network,

presence of cells expressing transcription factor CBFA1,

very few inflammatory CD14+ cells (macrophages),

an extracellular matrix positive for type I collagen.

Conclusion: The sheep metatarsal model is a model of critical size with low morbidity. This model could be used to:

evaluate new therapeutic strategies for bone regeneration in conditions close to clinical situations,

study the role of the membrane in bone repair.

The presence of a pseudosynovial membrane might:

be a barrier against the diffusion of bone morphogenetic proteins outside the lesion and

potentially be a reservoir of stem and vascular cells which could be useful for new technologies.


Stéphane DESCAMPS Philippe MOREEL Grégory ROCH Marc BERGER Stéphane BOISGARD Jean-Paul LEVAI

Purpose of the study: The mechanical and radiological course of bone allografts is often favorable but osteointegration properties could be improved. We associated a safe allograft with mesenchymatous bone marrow stem cells (MSC) with known osteogenic potential. The purpose of this preliminary study was to study the biocompatibility of the treated allograft, assess the osteoblastic differentiation properties of the MSC, and determine the optimal period for colonizing the bone matrix.

Material and methods: The support was a safe bone allograft preserved in a collagenic grid (Osteopure™). MSC harvested by adherence were seeded in a medium favoring osteoblastic differentiation by comparison with standard culture medium. Culture conditions varied to study the influence of the presence or not of support, the culture time, or the presence of human serum in the culture medium. For each culture medium, we noted: the number of cells, osteoblastic differentiation using markers: alkaline phosphate and osteocalcin. A histological study was also performed.

Results: Peak cell amplification was achieved at three weeks culture. Presence of osteoblastic differentiation markers was clearly identified in cultures grown in the presence of support material. Microscopy demonstrated that cells stimulated by the differentiation medium adhered strongly to the bone network. Histology revealed the presence of osteoblastic activity in differentiation medium with cells taking on the classical cytological aspect of osteoblasts. Cell proliferation was at least equivalent in medium with human serum as with fetal calf serum.

Discussion: This study demonstrated that the allogenic matrix does not modify the capacity of human MSC for colonization and differentiation. The cell organization is optimal compared with the absence of supporting material. Use of the patient’s own serum in the culture medium was validated enabling an autologous procedure. Use of a complex cell graft appears to be optimal after three weeks of culture. This first step proves the feasibility of the concept designed to optimize the support with the patient’s own MSC. The next step is to develop an in vivo model.


François AUBART Bruno MAUPETIT Livius FLORESCU Frédéric BARÈRE

Purpose of the study: This work was a retrospective review of bilateral total knee arthroplasties implanted by one operator during simultaneous or successive procedures. The purpose of the present study was to compare blood loss, operative time, iatrogenic effects, duration of management, and functional outcome in the two cohorts.

Material and methods: The study included 111 patients who underwent bilateral total knee arthroplasty (74 simultaneous implantations and 37 successive implantations). The procedures had been performed between January 1994 and December 2004. Management practices, and in particular transfusion practices, were the same. Care for postoperative pain (use of patient-controlled peridural injections) and rehabilitation practices were also similar for the two cohorts.

Results: There was not significant difference in postoperative complications between the two cohorts. Functional outcome was also the same. The duration of management was shorter for simultaneous operations. This was particularly noteworthy for older patients.

Discussion: Data in the literature is somewhat discordant concerning the use of simultaneous or successive procedures. There is an abundance source of data in the English literature but few reports from France. In our situation, we have used the analysis proposed by Hungerford concerning the outcome of the contralateral knee after insertion of one total knee arthroplasty. If the contralateral knee presents severe clinical signs and average radiographic anomalies or on the contrary average clinical signs and severe radiographic anomalies, we propose a simultaneous bilateral implantation. Pre- and postoperative care is particularly important for success.

Conclusion: Based on our experience, the benefit-risk-cost relationship favors simultaneous implantation of bilateral total knee arthroplasties in patients with advanced-stage bilateral degenerative joint disease.


Denis HUTEN Pierre IMBERT Xavier MAHIEU Patrick BOYER

Purpose of the study: Opinions vary concerning results after knee arthroplasty with preservation of the posterior cruciate ligament (PCL) in patients with rheumatoid disease. We report our findings in patients reviewed more than ten years after implantation in comparison with patients treated for osteoarthritis.

Material and methods: One surgeon implanted 43 knee arthroplasites (Kali) with preservation of the PCL (9 bilateral cases) in 31 women and 3 men, mean age 53 years (range 30–70 years). Outcome was assessed with the AKS clinical and radiological scores. Passive recur-vatum and posterior drawer at 90° flexion were measured radiographicaly at last follow-up. Outcome was compared with the results observed in a control group of 29 prostheses of the same type implanted for osteoarthritis (among a total of 203 implantations).

Results: There were no patients lost to follow-up: two patients were removed from the analysis due to infection on early wound necrosis and late metastatic infection. Eleven patients (16 prostheses) died before ten years follow-up; outcome was satisfactory for the prosthesis. Twenty-one patients (25 prostheses) were reviewed at more than ten years, mean follow-up 136 months. There was one case of supracondylar fracture which healed without sequela after osteosynthesis. The mean knee score was 34.3 preoperatively and 87.2 postoperatively with a mean function score improvement from 17 to 44 points. The pain score (47.3 points on average, was significantly improved while joint range of motion remained unchanged (117°). There were no worrisome lucent lines. Mean recurvatum measured radiographically was 6.9° (range 3–14°) and mean posterior drawer at 90° flexion was 4.2 mm. Outcome in the control group was the same excepting (p< 0.05) for lesser range of motion (109.7°) and better function score (62 points). Laxity (clinical and radiographic scores) were the same.

Discussion: The results obtained in patients with rheumatoid disease were satisfactory and the same as those obtained in patients with osteoarthritis and were comparable to those with prostheses sacrificing and replacing the PCL. There were no cases of prosthesis loosening. Complications were very limited and less frequent than among the entire population of 203 prostheses for degenerative disease.

Conclusion: Ligament alterations are not a contraindication for preservation of the PCL in patients with rheumatoid arthritis. Irrespective of the etiology, the main limitation on prosthesis longevity is polyethylene wear observed beyond ten years (ten changes of the plateau because of wear among 246 prostheses).


Véronique MOLINA Tanguy LE BALC’H Charles COURT Thierry LAMBERT Paul ZETLAOUI Jacques-Yves NORDIN

Purpose of the study: Hemophilic arthropathy is often located in the knee joint. Total knee arthroplasty (TKA) is the ultimate solution to total joint destruction, often observed in young patients. The purpose of this study was to evaluate the outcome of TKA in hemophilic patients and to describe specific features.

Material and methods: Hemophilics who underwent TKA between 1990 and 2004 were reviewed at mean 4.7 years follow-up: 30 TKA (7 posterior stabilized, 23 with preservation of the posterior cruciate) were implanted in 21 men, mean age 39 years, 17 with hemophilia A et 4 with hemophilia B. Seventeen patients were HBV-positive and eight were HIV-positive. Coagulation factors substitution was managed by the regional center for the treatment of hemophiliacs starting the day before the operation and for a minimal postoperative period of 21 days. The Knee Society score was used for assessment of clinical outcome.

Results: Preoperatively, mean flexion was 75° (range 40–100°), mean permanent flexion was 20° (range 5–45°). Range of joint motion was 56° on average (range of range of motion 10–105°). Early postoperative hemarthrosis occurred in eleven knees and seven of these required revision from day 4 to day 15. The four others resolved spontaneously. Six late infections (20%) developed in five patients (one bilateral infection). One patient was treated by arthroscopic wash-out, and four by arthrotomy. One required revision TKA in a two-stage procedure. Five patients received an adapted antibiotic therapy for an identified germ; the germ could not be identified in one patient. At last follow-up, mean flexion was 85°, mean permanent flexion was 10°, and mean range of motion was 71°. None of the patients complained of pain both at rest and during exercise.

Discussion: Hemophilic arthropathy is particularly painful, producing stiff joints in these immunodepressed patients. The known high rate of complications was again observed in this series, particularly infectious complications after TKA in hemophiliacs. These complications did not however alter the functional outcome. The gain in joint motion was modest but the absence of pain was a satisfactory result for these patients.


Olivier MANICOM Alexandre POIGNARD Gilles MATHIEU Paulo FILIPPINI Ali DE MOURA Philippe HERNIGOU

Purpose of the study: It is currently accepted that ligament balance should be one of the goals for total knee arthroplasty (TKA) and that this balance should be obtained by correct bone cuts or appropriate ligament procedures. There is however no standard way of assessing this balance. The purpose of this study was to define limit values for knee laxity observed in a series of normal knees and in a series of 54 TKA reviewed at more than ten years.

Material and methods: Laxity in extension of normal knees was measured on forced varus and valgus films using the contralateral knees of patients who had undergone knee surgery for osteotomy or prosthesis implantation. Laxity in extension of TKA knees was measured the first postoperative year and at last follow-up by measuring the decoaptation between the tibial and femoral pieces on single-leg stance films. The change in decoaptation over time was compared with the postoperative and last follow-up goniometry figures, the IKS knee score, the number of loosenings and the number of lucent lines. Multifactorial analysis was considered significant at p< 0.05.

Results: For the normal knees in extension, the medial compartment gap was 2 mm on average (range 1.5–3.5 mm) on the forced valgus images and the lateral compartment gap was 3 mm on average (range 2–4 mm) on the forced varus images. The corresponding angular value was 1° decoaptation on the forced valgus images and 1.5° on the forced varus images. Among the 54 knees with a TKA, the first postperative single-leg stance image revealed a lateral decoaptation _ 3° for 12 knees considered to present laxity, and was _ 2° for 42 knees considered not to present laxity. At last follow-up (13 years on average, range 11–14 years) the 42 knees without laxity remained unchanged without decoaptation, including the 34 normocorrected knees (±3°) and the eight undercorrected knees presenting more than 3° varus (mean undercorection 5°, range 3–7°). The 12 knees presenting postoperative radiographic decoaptation _ 3° showed at last follow-up a significant increase in laxity (p< 0.05) and 2.5° further increase in decoaptation. The increase in decoaptation occurred on normocorrected (n=7) or undercorrected (n=5) knees. This increase in decoaptation was greater with greater residual genu varum. Four groups of knees could be distinguished: normocorrected and stable; normocorrected and unstable; undercorrected and stable; overcorrected and unstable. The number of loosenings requiring revision and the number of progressive lucent lines were significantly greater among unstable knees (two loosenings, and five progressive lucent lines) than among stable knees (no loosening or lucent lines). They were also greater in the group of normocorrected and unstable knees (one loosening and two lucent lines) than in the group of undercorrected and stable knees (no loosening or lucent line). The IKS knee score of stable knees was higher than that of unstable knees irrespective of the correction (p< 0.05).

Discussion: Postoperative laxity in varus with angular decoaptation greater than 3° corresponds to a lateral compartment gap and should be avoided even if the knee is properly aligned postoperatively. If the knee is stable, moderate undercorrection (3–5° varus) does not appear to have an unfavorable long-term effect on knee laxity or on the femoral and tibial pieces.

Conclusion: For knees with constitutional genu varum, moderate undercorrection with a stable knee is preferable to normocorrection at the cost of lost stability.


Michel BONNIN Yannick CARRILLON Pierre CHAMBAT

Purpose of the study: Compar the position of the femoral piece in relation to the transepicondylar axis (TEA) using four different techniques for regulating rotation:

cut parallel to the posterior bicondylar line (BCL),

3° external rotation,

spacer method,

application of the formula: rotation = 1° + space in extension/2.

Material and methods: One hundred patients who underwent total knee arthroplasty (TKA) had a preoperative computed tomography (CT) scan. The surgical transepicondylar axis (TEA) and the BCL were drawn on the horizontal slices. The angle measured between these two lines (1.56°–2.5°) determined the theoretical angle of external rotation for aligning the femoral piece on the TEA. During the operation, femoral valgus was set to the HKS angle, measured by goniometry. The knife of the distal femoral cut, materializing the line perpendicular to the mechanical femoral axis, came in contact with the most distal femoral condyle (generally the medial condyle but occasionally the lateral condyle for varus femurs). The distance d between the knife and the most distal point of the condyle which remained distant was then measured. The external rotation was set at 0° and 3° with the techniques 1) and 2). For the technique 3), the asymmetry of the distal cut was projected on the posterior cut leading to an automatic rotation at an angle calculated trigonometrically. For the technique 4), the rotation was calculated as a function of the distance d. The difference between the external rotation obtained for each of these techniques and the theoretical rotation was calculated for each patient.

Results: The mean error of rotation obtained for the four techniques was respectively: 2.2–1.9°; 2–1.7°; 1.8–2.2°; and 1.5–1.4° (p< 0.05). The rate of malrotations greater than 1° for the four techniques was respectively: 60%, 58%, 41% and 36%. The rate of malrotations greater than 2° was respectively: 45%, 44%, 27% and 21%. This rate varied according to the femoral morphotype. The percentage of malrotations greater than 2° by technique was as follows for femoral morphotypes normal, varus, and valgus: technique 1: 37,34,58%; technique 2: 37,53,40%; technique 3: 7.5,9,26%; technique 4:22,30,40%.

Conclusion: Interindividual variations in the TEA-BCL angle explain the high rate of malrotation after regulated rotation. An adapted regulation will enable lesser risk of error. An adaptation taking into consideration the results of the preoperative CT scan appear to provide the most reliable results.


Sylvain LECLERCQ

Purpose of the study: The stability of the patella over the femur depends on several factors, one being the rotatory freedom of the tibia. Femorotibial rotatory laxity of a total knee arthroplasty (TKA) can be:

dictated by the congruence of the polyethylene in an ultracongruent plateau;

completely free, depending solely on the ligament structures in a self-aligning prosthesis;

the consequence of a compromise between the two, using a semi-constrained prosthesis. With the OMNIA system, the unique femoral piece can be combined with a Wallaby ultracongruent plateau (WUC), a self-aligning mobile plateau (SAL), or a semiconstrained plateau with preservation of the posterior cruciate ligament (Wallaby 1, W1). A comparative study of these three prostheses was performed to evaluate the influence of femorotibial rotatory constraint on patellar stability.

Material and methods: The series included 157 TKA: 68 SAL,44 WUC and 45 W1. The same surgeon operated all patients in three successive series. The operative technique was the same using the same instrument set. The femoral piece was inserted first with an automatic rotation systematically set at 5° with the posterior condyles. The knees were varus (71%), valgus (20%) and perfectly aligned (9%). A patellar prosthesis was used in only 10.8% due to excessive wear as assessed intraoperatively. A medial approach was used for the varus knees and a lateral approach for the valgus knees greater than 10°, independently of preoperative patellar stability. Radiological outcome was assessed on the 30° femoro-patellar views. Patellae tilted more than 3° and/or offset more than 5 mm were considered to be excentered.

Results: In the SAL group, 55 patellae were centered and 13 off-centered. The ratio was 36 for 6 in the WUC group and 39 for 6 in the W1 group. The percentages of centered patellae were respectively 80, 85, and 86%. The difference was not significant (p=0.66. For knees with preoperative genu varum, the percentages of centered patella were 83, 84, and 86%; and for genu varum, 72, 0 and 75% (sample too small for statistical significance).

Discussion: The use of rotatory constraint for TKA does not affect patellar stability. This was confirmed in a subpopulation of genu varum knees and not in genu valgum.


Philippe MASSIN Jean HEISMAN Stéphane PROVÉ

Purpose of the study: The accuracy, reproducibility and concordance of wear measurements made with the Imagika system were tested on knee prostheses.

Material and methods: Anteroposterior radiographic images of implants with tibial inserts measuring 9, 7, and 11 mm thick were obtained, the tibial base had a 28 mm bead for calibration. The ap images were digitalized and variations in incidence were controlled with a plumb line. Combining the tilt positions from −10° to +10° and rotation from −5° to +5°, a total of 132 images were obtained. Four groups were defined according to tilt and rotation (±5°, ±3°). The images were read by to observers. Reproducibility and agreement were assessed for the overall series and for each of the four groups. Two images were read 40 times by the same observer using variable digital quality (100–300dpi) to determine measurement accuracy and error. Results were compared with the manufacturer’s data sheet.

Results: Measurement agreement was poor in the four groups. Reproducibility was excellent at the 1% threshold for the overall series and for groups 3 and 4 for both observers. The accuracy improved from 0.6 to 0.5 mm by improving digitalization from 100 to 300 dpi with an error to the order of 0.05. Guiding the points used by the software for measurements, the accuracy could be improved to 0.25mm. The difference between the lateral plateau and the medial plateau appeared for the lesser tilt and for rotation greater than 2°. The thickness displayed was close only for the groups with little tilt.

Discussion: The reproducibility and accuracy of the Imagika system can be brought below the 0.5 mm threshold. For views without tilt, the difference compared with the displayed values varied from 0.1 to 0.3mm. The agreement remains poor if the position of the measurement points is not predefined by the system.

Conclusion: Offering an excellent reproducibility and good accuracy, the Imagika system enables monitoring TKA wear if the incidence of the radiographic images is perfectly controlled. For a more quantitative approach, the calibration method would have to be improved.


Srdan DOJCINOVIC Tarik AIT SI SELMI Philippe NEYRET

Purpose of the study: The objective of this study was to compare outcome after total knee arthroplasty (TKA) with a metallic tibial base versus full poly prostheses.

Material and methods: This monocentric retrospective study compared 169 Tornier full poly HLS TKA (group A) with 169 TKA with a fixed metallic tibial base (group B). The two series were matched for age, gender and etiology. Mean age was 71 years and female gender predominated, 80%. Mean follow-up was 66 months. Clinical (IKS score) and radiological outcome was assessed. Statview 5.0™ was used for the statistical analysis, Student’s t test for quantitative variables and chi-square test for qualitative variables. Differences were considered significant for p< 0.05. The beta factor was 0.2.

Results: The main intraoperative incidents were, weakening of the popliteal tendon (n=1) and supra and inter-condylar fracture of the femur (n=1) in group A patients and weakening of the popliteal tendon (n=2) and secondary fracture line of the medial tibial plateau (n=2) in group B patients. For group A, the knee score was 89±10.82 (mean±SD) and for group B 88.28±11.94. The function score was 68±23.75 for group A and 71±24.05 for group B. Mean flexion in both groups was 113°. Non-progressive tibial lucent lines were observed in 27 patients in group A and in 23 in group B. There were 7 replacements of the TKA in group A and 6 in group B. Survival for group A was 94.5% and 93.64% for group B.

Discussion: There were no significant differences concerning function and knee scores, presence of lucent lines and prosthesis replacement between the two series (p> 0.05).

Conclusion: This study did not demonstrate a superiority of the metallic tibial base TKA at five years follow-up. Use of a full poly TKA could decrease the medical cost by more than 30%.


Frantz LANGLAIS Nicolas BELOT Michaël ROPARS Jean-Christophe LAMBOTTE Hervé THOMAZEAU

Purpose of the study: Revision total knee arthroplasty with major destruction of bone and ligament tissue raises the problem of choosing between a complex reconstruction with a semi-constrained prosthesis or a much more simple procedure using a hinged prosthesis which transmits all of the stress to the bone anchors. The choice is basically one of longevity of the bony fixation of these constrained prostheses (and the deterioration of the articulated pieces). The present work reports the long-term outcome observed with constrained hinged prosthesis with a cemented press-fit stem implanted for bone tumors where the stress is even greater than for revisions.

Material and methods: The series included 32 prostheses implanted in young active subjects (mean age 33 years). A hinged, non-rotating Guepar II revision prosthesis was implanted. The part of the implant corresponding to the reconstruction after tumor resection was custom-made but the part implanted in «healthy» bone (for example the tibial piece in a patient with a femoral tumor) was the same as used for revisions prostheses inserted after loosening. On the healthy side, press-fit quadrangular stems were used, generally adapted to the endosteum by reaming. The prosthesis was fixed by simple mechanical adjustment before cementing, using the French paradox system (JBJS 2003). Before 1993, a metal-polyethylene bearing was used and after 1993 a metal-on-metal bearing without inserts.

Results: Among the 32 patients with a malignant tumor, 19 survived, seven with 2–10 years follow-up and 12 with 10–21 years follow-up. For the overall series, there was only one case of osteolysis on a tibial tumor which was revised at 12 years. There was one infection (hematogeneous) at 21 years (antibiotic cement). Prostheses with polyethylene inserts produced laxities or synovitis with 50% requiring synovectomy and insert replacement. There were no cases of synovitis for the metal-on-metal bearings. Two stems (inserted in adolescents) were too thin and had to be changed because of fracture without loosening.

Discussion: Prosthesis survival was 88% at ten years (1 osteolysis, 2 fractures on tumor), even for the constrained prostheses, even for young and active subjects.

Conclusion: The very good longevity of cemented pressfit stems (and the absence of synovitis and osteolysis with metal-on-metal bearings, and the low rate of infection) should be kept in mind as a possible alternative to very complex and possibly less predictable procedures in the presence of certain very severe loosenings with bone and ligament destruction.


François LECUIRE Denis GONTIER Jacqueline CARRERE Maurice BASSO Ignaki BENAREAU Jérôme RUBINI

Purpose of the study: Staphylococcus lugdunensis, described in Lyon in 1988 by Freney, appears to be a member of the cutaneous perineal flora. Since the first description, S. lugdunensis infections are regularly reported. The germ has been reported as the causal agent for endocarditis on valve prostheses with a very severe prognosis, requiring surgery in addition to medical management. We wanted to ascertain the prognosis of such infections on joint prostheses and to determine if it is different from that with other staphylococcal species.

Material and methods: Since 1991, seven S. lugdunensis infections on a joint prosthesis (three total hip prostheses and four total knee arthroplasties) were identified in our department. The Api Id 32 staph (BioMérieux SA) test battery was used for identification. All patients underwent surgical treatment and were given a prolonged antibiotic regimen. Simple joint cleaning was performed in three cases, one requiring a one-stage prosthesis replacement. There were four two-stage prosthesis replacements. The antibiotic regimen was always long (3–8 months) and was continued as a palliative treatment in two patients who underwent simple cleaning.

Results: One elderly woman with multiple co-morbid conditions died after prosthesis removal before the replacement procedure could be performed. There were no cases of recurrent infection at 16 months and 6 years for the four prosthesis replacements (one- and two-stage procedures). Arthroscopic cleaning without removal of the TKA was a failure in one patient who required prosthetic replacement later. Two simple cleanings in elderly patients were failures and required continuous palliative antibiotics.

Discussion: Staphylococcus lugdunensis is generally considered to be very susceptible to antibiotics in vitro. In our experience, search for minimum inhibitory concentrations and minimum bactericidal concentrations have shown cures with rapid shifts which must be taken into consideration when choosing an antibiotic. With surgical removal of the prosthesis and adapted antibiotics, the prognosis of these infections is not different from other staphylococcal infections of joint prostheses. We did however note two cases of secondary infections, probably related to hematogeneous spread, which developed from an unidentifiable point in time.

Conclusion: Staphylococcus lugdunensis is a coagulase-negative staphylococcus with poorly known virulence properties. In our very small series of joint prostheses infections, therapeutic failure occurred when the infected prosthesis was not removed.


Pierre-Henri FLURIN Philippe LANDREAU Pascal BOILEAU Nicolas BRASSART Christophe CHAROUSSET Olivier COURAGE Elias DAGHER Nicolas GRAVELEAU Thomas GRÉGORY Stéphane GUILLO Jean-François KEMPF Laurent LAFOSSE Bruno TOUSSAINT

Purpose of the study: A statistical analysis of correlations between clinical outcome and anatomic results after arthroscopic repair of rotator cuff tears.

Material and methods: This multicentric series of rotator cuff tears was limited to the supraspinatus and infraspinatus. The statistical analysis searched for correlations between the clinical outcome (Constant score) and anatomic results (arthroscan and arthroMRI). The series included 576 patients, mean age 57.7 years, 52%μ males and 60% manual laborers. The tear was limited to the suprapsinatus in 69% of patients, with extension to the upper third of the infraspinatus in 23.5% and all tendons in 7.5%. The supraspinatus tear was distal in 41.7% of patients, intermediary in 44% and retracted in 14.3%. Fatty degeneration of the supraspinatus was noted grade 0 in 59.7%, 1 in 27.1%, 2 in 10.8% and 3 in 2.4%.

Results: The Constant score (46.3 preoperatively and 82.7 postoperatively) was strongly correlated with successful repair. The correlation was found for force, motion, and activity, but not for pain. The clinical outcome was correlated with extension, retraction, cleavage, and degeneration of the preoperative injury. The anatomic result was statistically less favorable for older, more extended, retracted, and cleaved tears or tears associated with fatty degeneration. Age was correlated with the extent of the initial tear and also with less favorable clinical and anatomic results. Work accidents were correlated with less favorable clinical outcome.

Discussion: The large number of anatomic controls with contrast injection facilitated demonstration of several statistically significant correlations. This enabled disclosure in a single series of evidence confirming earlier reports in the literature: repair of cuff tears improves the overall functional outcome for massive tears; the anatomic result depends on the size of the initial tear; pre-operative fatty degeneration is an important prognostic criteria; cuff healing is age-dependent.

Conclusion: Study of anatamoclinical correlations helps guide therapeutic decision making and enables the establishment of reliable prognostic criteria after arthroscopic repair of rotator cuff tears.


Christophe CHAROUSSET Louis-Denis DURANTHON Jean GRIMBERG Laurence BELLAÎCHE

Purpose of the study: Arthroscopic repair of rotator cuff tendons is a well-described technique. Clinical outcome is good. The purpose of this work was to assess tendon healing as observed with the arthroscan after arthroscopic repair of rotator cuff tears. We search for epidemiological, anatomic, and technical factors predictive of healing.

Material and methods: This was a prospective consecutive non-randomized series of 167 shoulders. All patients were assessed preoperatively with the Constant clinical score and had a standard imaging protocol for assessing the status of the rotator cuff. Arthroscopic repair was used in all cases. Outcome was assessed with the Constant score and an arthroscan was available for 148 patients.

Results: Mean patient age was 59 years, 49% male and 77% dominant side. Mean duration of symptoms before repair was nine months. The tear resulted from trauma in 28% and was a work accident in 9%. The preoperative functional assessment was 52.48. An isolated supraspinatus tear was observed in 68% of the shoulders. Frontal retraction of the supraspinatus was distal in 74%. For 29 shoulders, reduction was difficult and the quality of the tendon was considered normal in 56. Non-anatomic repair was required in six cases. The Constant score at last follow-up (19 months) was 80. An arthroscan was available for 148 shoulders: healing was anatomic in 69, defective healing was observed in 27 and repeated tears were noted in 52. Factors predictive of healing were: demographic (lesion duration less than six months, non-dominant side, young patient, female gender, sedentary lifestyle); anatomic (isolated lesion of the supraspinatus with little extension and no retraction); technical (normal easily reduced tendon, good quality bone).

Discussion: The time before surgical management of rotator cuff tears was an important factor in this study. Tendon and muscle alterations after rotator cuff tears could explain, at least in part, healing failures.

Conclusion: This study confirmed the good functional and anatomic results obtained with arthroscopic repair of rotator cuff tears.


Philippe LANDREAU Pierre-Henri FLURIN Pascal BOILEAU Nicolas BRASSART Christophe CHAROUSSET Olivier COURAGE Elias DAGHER Nicolas GRAVELEAU Thomas GRÉGORY Stéphane GUILLO Jean-François KEMPF Laurent LAFOSSE Bruno TOUSSAINT

Purpose of the study: Completely arthroscopic repair of rotator cuff tears is widely considered as the standard treatment. We reviewed a multicentric retrospective series of patients.

Material and methods: This series of arthroscopic repairs of full-thickness tears of the supraspinatus and infraspinatus were assess with the Constant score together with arthroMRI or arthroscan at one year follow-up at least. Data were analyzed with SPSS10. The series included 576 patients who underwent surgery from January 2001 to June 2003. Mean age was 57.7 years, 52% males and 60% manual laborers. Mean preoperative Constant score was 46.4/100 (r13.4). The tear was limited to the supraspinatus in 69% of patients with extension to the upper third of the infraspinagus for 23.5% and to all tendons for 7.5%. The supraspinatus tear was distal in 41.7% of patients, intermediary for 44%, and retracted for 14.3%. Arthroscopic repair was performed in all cases, with locoregional anesthesia for 60.9%. Implants were resorbable for 33% and metallic for 62.1%. Acromioplasty was performed for 92.7% and capsulotomy for 14.9%.

Results: The mean subjective outcome was scored 8.89/10. The Constant score improved from 46.3±13.4 to 82.7±10.3 with 62% of patients being strictly pain free. The force score improved from 8.5±3.7 to 13.6±5.4. Outcome was excellent or very good for 94% of the shoulders at 18.5 mean follow-up. The rate of complications was 6.2% with 3.1% of patients presenting prolonged joint stiffness, 2.7% reflex dystrophy, 0.2% infection and 0.2% implant migration. The cuff was considered normal in 55.7% of the shoulders with an intratendon addition image for 19%, i.e. 74.7% non-torn cuffs. A point leakage was noted in 9.5% with pronounced leakage in 15.7%, i.e. 25.2% recurrent tears.

Discussion and conclusion: The functional outcome obtained after arthroscopic repair of rotator cuff tears is good. Arthroscopy has the advantage of a low rate of complications yet provides good clinical and anatomic results. Age is correlated with functional outcome and healing, but should not be considered as a contraindication.


Guillaume DEMEY Elvire SERVIEN Philippe NEYRET Tarik AIT SI SELMI

Purpose of the study: Cysts are rarely identified in the anterior cruciate ligament; the pathogenic mechanisms involved are poorly understood. We investigated the anatomic and clinical presentation.

Material and methods: This retrospective analysis included 24 patients, seven women and seventeen men managed in a single center from 1998 to 2004. Mean patient age was 45 years (range 25–74 years). All patients complained of pain. A preoperative MRI was available for all patients. Mean follow-up was 25 months (range 6–48 months). Arthroscopic procedures were used for 17 patients and the IKDC subjective score was determined preoperatively in all. Radioguided (US or CT) puncture was performed for seven patients associated with corticosteroid injections.

Results: On the MRI, there were 16 infiltrating cysts and eight cystic formations. Surgical treatment (n=17) was performed for 13 infiltrative cysts and for four cystic formations. There were two cases of recurrence. Outcome was poor after puncture (two puncture failures, three recurrences and one vascular complication).

Discussion: Two forms of cysts of the ACL can be demonstrated by MRI. The clinical presentation may not be different but the therapeutic management should be. The cystic formation is an indication for puncture, with arthroscopic treatment in the event of failure. For infiltrating cysts, complete resection of the cyst during an arthroscopic procedure is indicated, sometimes associated with resection of the ACL. Puncture yields poor results.


Sébastien PARRATTE Nicolas JACQUOT Cédric PELEGRI Christophe TROJANI Pascal BOILEAU

Purpose of the study: Arthroscopic reinsertion of SLAP lesions is the most commonly used approach. Tenodesis of the long biceps could be proposed as an alternative to reinsertion. The purpose of our study was to report the results of tenodesis and reinsertions for the treatment of type II SLAP lesions.

Material and methods: This was a consecutive monocentric comparative series analyzed retrospectively. Isolated type II SLAP lesions treated arthroscopically were retained for study: 25 cases treated from January 2000 to May 2004. Exclusion criteria were: associated instability, associated cuff tears, history of surgery. The long biceps tendon was reinserted on the glenoid tubercle using two threads mounted on resorbable anchors in ten patients (all men), mean age 27.5 years (range 19–57 years). Tenodesis of the long biceps in the gutter was performed in fifteen patients (six women and nine men), mean age 52.2 years (range 28–64 years). All patients were reviewed by an independent observer.

Results: In the reinsertion group, mean follow-up was 35 months (range 12–57 months). Three patients had revision tenodesis due to persistent pain and three others were disappointed because they were unable to resume their former sport. Four others were very satisfied. The mean Constant score improved from 65 to 83 points. Force was 16 kg in flexion and 5 kg in supination. In the tenodesis group, mean follow-up was 34 months (range 12–56 months). There were no revision procedures in this group. Subjectively, one patient was disappointed (atypical pain), two were satisfied and 12 very satisfied. The mean Constant score improved from 59 to 89 points. Force was 14.5 kg in flexion and 4.8 kg in supination.

Discussion: This series showed that results obtained with reinsertions can be disappointing: three revisions and three disappointed patients among ten procedures. In the tenodesis group, 14 of 15 patients were satisfied or very satisfied. Tenodesis of the long head of the biceps can be considered as an alternative to reinsertion for the treatment of type II SLAP lesions, particularly in older athletes.


David TOURAINE Philippe CLAVERT Pierre MOULINOUX Jean-François KEMPF

Purpose of the study: First described in 1990, superior labral anteroposterior (SLAP) lesions are uncommon and remain a subject of debate. Initially treated by decridement and vivication, indications for reinsertion became increasingly population. The purpose of this study was to evaluate the long-term outcome of arthroscopic treatments.

Material and methods: Isolatd SLAP lesions were treated in 24 patients from 1996 to 2002. This study excluded all patients with rotator cuff tears, glenohumeral instability, a posterosuperior impingement, osteoarthritic degradation, or acromioclavicular pain. Thirteen patients (54.2%) reported that trauma was the triggering factor. Sixteen of the 24 patients practiced sports (seven leisure sports and nine competition sports included two at a high level). The diagnosis of SLAP lesion was suspected preoperative in 15 patients (62.5%) on the basis of clinical and arthroscan findings.

Results: The Snyder classification at arthroscopy was: type I (n=5, 21%), type II (n=17, 71%), type III (n=2, 8%). Debridement avivement was used for type I and III lesions. SLAP II lesions were treated by suture on one or two anchors. There were three complications: one anchor migration and two cases of reflex dystrophy. Twenty cases were reviewed with mean four year follow-up (minimum two years) (ten patients seen at consultation and ten with phone interviews). Only six patients recovered complete shoulder function. Among the ten patients examined, the Constant score improved 18.5 points. 65% of patients were satisfied or very satisfied.

Discussion: The results obtained in this series are in agreement with the literature. Repeated procedures performed in athletes or other professionals favor SLAP lesions. Diagnosis is difficult. Type II SLAP lesions predominate. We did not have any type IV lesions in this series. Adapted surgical treatment enables more or less complete resolution of the symptoms. Resumed physical activity at the same level cannot be guaranteed for the athlete.

Conclusion: SLAP lesions are a rare entity and are difficult to diagnose. Such lesions are a potential diagnosis in the event of posttraumatic painful shoulder or in patients exposed to repeated movements. Arthroscopic treatment is the rule, even though the outcome is uncertain.


Guillermo ARCE Pablo LACROZE Juan PREVIGLIANO Eduardo COSTANZA Matias CAÑETE

Purpose of the study: The rate of recurrence after conventional manipulation procedures and arthroscopic debridement for idiopathic adhesive capsulitis of the shoulder is rather high. Arthroscopic release using a radiofrequency method might improve results. The purpose of this prospective study was to compare results of two athroscopic methods: manipulation and debridement versus radiofrequency release.

Material and methods: Thirty patients underwent arthroscopic treatment for shoulder pain six months after a conventional treatment for idiopathic adhesive capsulitis. In group A (n=15 patients), manipulation under anesthesia was followed by arthroscopic joint debridement. In group B (n=15 patients) arthroscopic section of the contracted structures was followed by radiofrequency section of the rotator interval and the anterior and posterior capsule. The coracohumeral ligament was sectioned in all cases. Subacromial decompression was achieved arthroscopically in four of the cases in group A and in two in group B. Age, gender and preoperative joint motion were similar in the two groups.

Results: Follow-up data at six weeks and at 3, 6, and 12 months were assessed in 27 patients (12 group A and 14 group B). Pain, joint stiffness, and function (UCLA and Constant) were assessed. Recurrence required revision in two patients in group A. There was no significant difference for pain (VAS) but there was an improvement in joint motion at three and six months for patients in group B. The outcome was satisfactory in all patients except one.

Discussion and conclusion: Radiofrequency release appears to yield better results than manipulation and arthroscopic debridement. The radiofrequency technique enables section of the rotator interval, the coracohumeral ligament and the capsule to prevent early adhesions and allow more rapid recovery of function.


Lionel Neyton Sébastien PARRATTE Cédric PELEGRI Nicolas JACQUOT Pascal BOILEAU

Purpose of the study: Depending on the series, fractures of the anteroinferior glenoid labrum have been reported in 3% to 90% of patients with anterior shoulder instability. These fractures disrupt the physiological glenoid concavity and shorten the effective length of the glenoid arch. Indications for treatment depend on the size of the fragment and range from osteosynthesis to resection or suture. We hypothesized that these lesions could be treated arthroscopically (Bankart procedure with fragment suture). The purpose of this work was to analyze clinical and radiological outcome observed in nine patients with anterior instability associated with significant glenoid fracture.

Material and methods: This was a monocentric study of a continuous series of nine glenoid fractures associated with anteromedial dislocation in nine patients (three women and six men), mean age 35.5 years (range 17–75 years). Preoperatively, all of the fractures were considered to involve more than 25% of the glenoid surface. After detaching the capsulolabral lesion with the bony fragment and avivement of the anterior border, the Bankart procedure was performed with anchors and resorbable sutures. The shoulder was strapped for six weeks with passive rehabilitation (pendulum movements) initiated early.

Results: Mean follow-up was 27 months (range 12–48 months). There were no cases of recurrent instability. Seven patients were very satisfied and two were satisfied. Eight patients were able to resume their sports activities at the same level. Apprehension developed in all patients. At last follow-up, joint motion was normal for eight of the nine patients, the Duplay score was 100 for eight patients and 45 for one. All bony lesions healed in an anatomic position (six analyzed with plain x-rays and three with CT scan).

Discussion and conclusion: This short series demonstrates that glenoid fractures can be treated arthroscopically with concomitant treatment of the capsulolabroligament complex in order to reconstruct the glenoid arch, an essential element for restoring shoulder stability. It is thus necessary to identify bony lesions preoperatively to determine the most appropriate therapeutic approach. A long-term follow-up will be useful to assess the rate of recurrent instability and validate this therapeutic option.


Pierre LASCOMBES Gérard BOLLINI Thierry HAUMONT Philippe MAXY Fabienne GAIRIN François PLÉNAT Samuel BERTRAND

Purpose of the study: In the growing pig, we have been able to achieve localized control of vertebral body growth by selective destruction ofhte physis using the thermal effect of a laser probe (first part of the study). The purpose of the second part of the study was to evaluate the mechanical effects in terms of 1) intersomatic disc mobility, and 2) bony resistance of the vertebral body and risk of fracture.

Material and methods: Thoracotomy was performed on two Yucatan micropigs (group A); a 510 nm 30W diode laser delivered heat applied to nine vertebral bodies. Four months later, the micropigs were sacrificed. Two normal micropigs (group B) served as controls. The specimens were dissected to the intersomatic disc-ligament complex. Three-level vertebral assemblies were thus obtained for mobility tests (flexion-extension, lateral inclination, right-left rotation). Destruction tests were pursued to fracture. Tests were performed with a Zebris 3D motion analyzer. Computed tomography images and histological findings were also assessed.

Results: Motion: In group A, when the discal space appeared normal on the specimen, no difference was noted in motion in comparison with group B. Conversely, when imaging demonstrated discal injury, joint stiffness was noted. The destruction tests showed that in group A specimens the fracture did not occur at the zone of lytic bone destruction caused by the heat delivery. Fractures observed were similar in the two groups, including epiphyseal detachements and sagittal fractures of the vertebral bodies.

Discussion: Applying laser-delivered heat to the vertebrae in micropigs enabled partial destruction of the physis without injuring the intervertebral disc. Heat delivery induced a modification in vertebral growth. When imaging showed an intact neighboring intervertebral disc, mechanical tests showed normal mobility and resistance. Bone resistance was not diminished. This result is important to consider for the treatment of vertebral osteoid osteomas with laser.

Conclusion: Laser application to vertebral bone is a reproducible method which can stop growth of the minipig vertebral bodies without injuring the intervertebral disc and without reducing bone resistance.


Yvan LE CONIAT Jean-François KEMPF Philippe CLAVERT Pierre MOULINOUX François BONNOMET

Purpose of the study: This retrospective study was conducted to analyze the mid-term effect of damage to the anteroinferior rim of the glenoid cavity in failed arthroscopic stabilization of the shoulder.

Material and methods: From 1999 to 2001, 54 patients underwent surgery performed by the same operator. Full data were available for analysis for 46 patients. Mean age was 28 years and mean follow-up four years. A pre-operative scan was available for all patients to analyze the bone lesions. The same technique was used for all shoulders: three or four suture points using resorbable thread attached to a Panolok anchor with a north-south retension effect. The Duplay score was noted at last follow-up. Experimental work by Gerber, which demonstrated that the anti-dislocation resistance decreased as a function of the ratio (x) between the length of the anteroinferior glenoid defect and its maximal antero-posterior diameter, was used to assess resistance to dislocation. This resistance decreased 30% when x=0.5 and 50% when x=0.75.

Results: The Duplay score at 47 months was 83.3. The rate of recurrence was 13% (n=6). Age, sex, and number of episodes of instability had little effect on outcome. The rate of recurrence (38%) in patients with a significant damage (x> 0.5) was much higher than in patients with minimal damage (x< 0.5) (2.2%). The difference was statistically significant (p< 0.01). The Duplay score (63.8 points) in patients with significant damage (x> 0.5) was significantly lower (p=0.01) than in patients (91 points) with minimal damage (x< 0.05).

Discussion: The presence of bony lesions of the anterior glenoid rim appears to be one of the most important prognostic factors of recurrence. Considering the high frequency of these lesions in our series (54%), this element deserves careful analysis which would require computed tomographic reconstruction in the sagittal plane to obtain a precise assessment of the loss of articular surface. The statistical analysis demonstrated that patients with important loss of articular surface (x> 0.5) had a significantly higher risk of recurrent instability (p< 0.01).

Conclusion: Arthroscopic stabilization of the shoulder joint yields results similar to those obtained with more conventional techniques. Our study confirmed this notion showing a rate of recurrence of 13% which could be reduced to less than 3% with careful preoperative assessment of glenoid articular surface loss on the preoperative scan.


Olivier DELATTRE Lucian STRATAN Wael DAOUD Pierre ABADIE Choukry DIB Antoine COUSIN Claude SERRA Jean-Louis ROUVILLAIN Yves CATONNÉ

Purpose of the study: Analyze failures (recurrent anterior instability) and other complications (pain, stiffness) compromising the overall outcome after arthroscopic anterior shoulder stabilization.

Material and methods: We studied failures and complications in a consecutive inaugural series of 43 patients undergoing an arthroscopic Bankart procedure for chronic anterior shoulder instability. The procedure was performed with knitted resorbable threads on metallic anchors. Outcome was reviewed at mean 26 months (range 6–63 months). There were 19 recurrent dislocations, 12 recurrent subluxations, 4 cases of recurrent subluxation and dislocation and 6 cases of painful unstable shoulder. Mean patient age was 35.6 years (range 19–59 years). Thirty-two patients practiced sports, including 21 who practiced high-risk sports.

Results: One patient, a competition basketball player, presented recurrent traumatic dislocation due to a violent shock after premature resumption of sports activities five months after surgery. There were no recurrent dislocations among the subluxation cases. Pain persisted in three of the six painful unstable shoulders. Sixteen patients presented persistent apprehension but none complained of instability. Nine patients had a positive relocation test. Limited external rotation of less than 30% as observed in five patients and of 30–50% in two. Residual pain was observed in 14 patients (33%) (when carrying a heavy load with the arm hanging along the body, with fatigue, and for forced movements without warm-up in the morning). For four patients, pain occurred in the armed position. Seventeen patients (43%) interrupted their sports activity. The Duplay score showed 13 (30%) fair and poor objective overall results. Subjectively, only seven patients (15%) were only partially satisfied or dissatisfied.

Discussion: Analysis of failures and complications disclosed a discordance between the low rate of failure using the classical definition (recurrent dislocation or subluxation) and the high rate of fair or poor overall outcomes. Residual pain and non-resumption of sports activities appeared to be the major problems. These two factors were analyzed in detail to compare this series with data in the literature. It was found that non-resumption of sports activities is not always related to shoulder instability or apprehension and that pain is often related to associated injury (SLAP, cuff). Conversely, pain associated with a positive relocation test should be considered as a true recurrence, especially in a subject who was unable to resume sports activities.


Gérard BOLLINI Pierre LASCOMBES Yann GLARD Philippe PETIT Frédéric LACROIX Fabienne GAIRIN François PLENAT

Purpose of the study: Attempts to control growth of the spine without provoking epiphysiodesis is a promising area of investigation. The purpose of our experimentation was to achieve localized interruption of vertebral body growth without damaging the adjacent disc and ligament structures.

Material and methods: Two Yucatan micropigs weighing 7 and 9 kg were used for this study. Before initiating the experiment, a complete imaging work-up (x-ray, computed tomography, magnetic resonance imaging) of the spine of the two pigs was obtained. The animals were anesthetized for thoracotomy and a 810 nm 30W laser diode (Diomed Ltd) was implanted in the superolateral part of nine vertebral bodies (3 mm under the cartilage endplate and 3 mm in depth) in order to apply a certain quantity of heat. The nine vertebrae were divided into three groups of three vertebrae. Each group received 2W for 200, 300, or 400s (groups 1, 2 and 3 repectively). The temperature generated by the thermal delivery was recorded in the growth cartilage and in the disc using thermal probes. A complete imaging series of the spine was again obtained four months later, before sacrifice. The results presented correspond to the CT-scan findings used to analyze the effect on vertebral growth and to the MRI findings used to check for discal injury. Each vertebral level was sampled for a histological examination and (in the second part of the study) a biomechanical analysis was undertaken.

Results: Among the 18 vertebral levels studied (two micropigs), 11 levels exhibited localized interruption of growth without any alteration of the adjacent discs. We were unable to observe any significant correlation between the temperature recorded in the disc and the discal structure observed at sacrifice, although above 52°C, there appeared to be a greater risk of definitive discal damage. As disc growth can be controlled (as demonstrated in this study) without damaging the adjacent disc (which will require further study to demonstrate) is would be possible to use this technique as an alternative to treatment by corset for progressive idiopathic scoliosis in growing children.


Mario LARRAIN

In the international literature, the rate of recurrence after conservative treatment of traumatic anterior dislocation of the shoulder joint is high. Rates are highest in young subjects and violent sports. Recent publications report a lower rate of recurrence after immobilization in external rotation but with a short follow-up and in heterogeneous groups where contact sports were not individualized.

Between August 1989 and April 1997, we conducted a prospective study to assess outcome in contact sports athletes aged at least 30 years (arthroscopy, 2001) Comparing the results of surgical and non-surgical treatment showed excellent or good outcome in 96% of the surgery group and in 94% of the non-surgery group.

Later publications showed that chronic disease is an important negative factor for bone and cartilage tissue quality at repair.

Between August 1989 and March 2005, we have performed 97 first-intention arthroscopic repair procedures in contact sport athletes and have obtained anatomic repair more easily with better quality tissue and better outcome with a lower rate of recurrence as well as more rapid resumption of training.


Saleheddine KARRAY Ahmed CHTOUROU Anis KHARRAT Mohamed HEDI MEHRZI Sofiène KALLEL Mongi DOUIK

Purpose of the study: Pott’s disease of the cervical spine is exceptional. We collected 27 cases over a period of 30 years.

Material and methods: Mean patient age was 21 years. Male gender predominated. Most patients consulted because of cervical pain and 50% presented neurological disorders. Mean duration of symptoms was 14 months. A peri-spinal abscess was found in ten patients. The posterior cervical spine was affected in most patients and four presented suboccipital involvement. There was associated lung disease in two-thirds of the patients. Standard anti-tuberculosis chemotherapy was given associated with traction alignment in twelve patients to correct for kyphosis or associated spinal dislocation. Surgery was reserved for major bone destruction leading to instability or neurological disorders resistant to medical treatment.

Results: Mean follow-up was five years. The anatomic result after medical or surgical treatment was characterized by vertebral fusion in all patients. There were three serious neurological complications after surgery. Improvement was achieved in eleven of the twelve patients with inaugural neurological complications.


Pierre BERNARD Jean-Marc VITAL Jean HUPPERT Jean-Marc FUENTES Jacques BEAURAIN Thierry DUFOUR Istvan HOVORKA

Purpose of the study: Discectomy-anterior fusion has proven efficacy for many diseases of the cervical spine. Nevertheless, the loss of motion and the over-solicitation of adjacent levels are arguments in favor of disc replacement. This prospective study examined the early clinical and radiological results obtained in the first 41 patients treated with a new cervical disc prosthesis, Mobi-C.

Material and methods: A prospective multicentric clinical and radiological study is being conducted to analyze the safety and efficacy of Mobi-C for degenerative disease. Indications are radiculopathies due to discal herniation or foraminal osteophytic stenosis involving one or two levels from C3 to T1. An independent observer reviewed the patients. SF36, the Neck Disability Index, and a visual analogue scale for pain as well as radiographic mobility were noted.

Results: Mean age was 42 years (range 31–56 years). There were 23 men and 18 women. Eight patients had two disc replacements. Mean follow-up was six months (range 3–10 months). Mean operative time was 65 min, similar to operative time for fusion. Blood loss was 90 ml. NSAID were prescribed for the first 15 days. There were no intraopeartive complications and no revisions. Postoperative complications were minimal. There were no specific complications related to the prosthesis, its insertion or its function. The function and quality-of-life scores showed a significant improvement at last follow-up. Radiographically, motion was also improved in most patients.

Discussion: The early results on the safety and efficacy of this new cervical prosthesis are promising. Primary stability has been excellent and there have been no specific prosthesis-related complications. Furthermore, several operators have mentioned how easy it is to insert the Mobi-C.

Conclusion: The clinical results in terms of pain and function as well as the radiological results have been satisfactory both at the early and at the later assessments. Insertion of this prosthesis is a simple process, similar to insertion of an intersomatic cage, elements arguing in favor of a cervical disc prosthesis. Further follow-up will be needed to assess the long-term efficacy and possible effect on prevention of accelerated degeneration of the adjacent discs.


Jérôme SALES DE GAUZY Vincent GLORIEUX Philippe DUPUI Richard MONTOYA Jean-Philippe CAHUZAC

Purpose of the study: The effect of idiopathic scoliosis surgery on walking capacity has rare been studied. Results published in the literature have been discordant: reduced velocity, step rate and stride length for Lenke et al; no change for Engsber et al. We conducted a prospective study to analyze gait parameters after surgery for idiopathic scoliosis.

Material and methods: This study was conducted in 46 patients who underwent surgery for idiopathic scoliosis. Mean age was 15 years (range 12–22). Mean angle was 56° (range 40–94°). A posterior approach was used for reduction and fusion in all patients. Mean postoperative angle was 20° (range 8–64°). There were no neurological, mechanical or infectious complications. Gait analysis was performed with a locometer to record spatial and temporal gait parameters preoperatively then postoperatively at 10 days, and 3, 6, and 12 months. ANOVA was performed.

Results: Preoperatively, mean±SD values were: velocity: 1.48±0.14 m/s; step rate: 132±9 steps/min; stride length 67±6.7 cm; balancing time: 0.39±0.03 s; double-stance time 0.07±0.03 s. These values were lower than reported for health adults using the same measurement instrument. All parameters were modified immediately after surgery (p< 0.05) but there was no significant difference between the pre- and postoperative values at 3, 6, and 12 months.

Conclusion: Corrective fusion via a posterior approach for the treatment of idiopathic scoliosis does not affect spatial and temporal gait parameters.


Joël DELÉCRIN Hervé CHATAIGNIER Jérôme ALLAIN Jean-Paul STEIB Jacques BEAURAIN

Purpose of the study: The theoretical usefulness of a disc prosthesis in comparison with arthrodesis would be to restore physiological segmental motion without perturbing the kinematics of the adjacent levels. The purpose of this study was to determine the rotation centers of the lumbar segments before and after implantation of a disc prosthesis with a mobile insert (Mobidisc™).

Material and methods: Lateral flexion and extension views in the sitting position with a stabilized pelvis were obtained before and after implantation of the lumbar disc prosthesis in 32 patients. Spineview™ was applied to the digitalized images for semi-automatic recognition of the vertebral body contours and calculation of the rotation centers. The detection threshold for this automatic system was 5° motion.

Results: Rotation centers were difficult to determine preoperatively because of the absence of mobility. A pathological position was found for three patients. Postoperatively, at three and twelve months, the position was «physiological» in 13 patients, in the posterior half of the disc or inferior body near the vertebral end plate. IN 14 patients, the center could not be determined because motion measured 5° or less. For three patients, the center was too anterior on a prosthesis implanted to anteriorly. There were no changes in the rotation centers for the adjacent levels.

Discussion: Demonstration of an abnormal rotation center could be an additional indication of presumed instability. In certain cases, a disc prosthesis appears to restore the physiological rotation center. But the position and the thickness of the implant can influence their localization.

Conclusion: Restoration of a physiological rotation center for the instrumented intervertebral segment and the absence of change in the rotation centers for the adjacent centers are arguments in favor of disc prosthesis for reducing the incidence of osteoarthritic degradation of adjacent discs in comparison with fusion, under the condition that the implantation and the size are correctly adapted.


Alexis NOGIER Gérard SAILLANT Hedi SARI-ALI Sabina MARCOVSHI Alexandre TEMPLIER Wafa SKALLI

Purpose of the study: The mean rotation center (MRC) characterizes the movement of two solids in relation to each other. This parameter has been proposed for the cervical spine to describe the motion of vertebral segments. Two lateral views (flexion and extension) are required to draw the necessary lines and establish the centers of rotation. The process is rigorous but time-consuming. We validated a computerized analysis system for automatic determination of the cervical MRC and study the localizations observed in healthy subjects.

Material and methods: Validation of the computerized system. Accurate angle measurements: nine cervical spines were harvested from anatomic specimens. A K-wire was inserted sagittally into each vertebra. Lateral images were obtain in flexion and extension. The measurements of mobility made by the software were compared with manual measurements. Reproducibility tests (intra- and interobserver): six pairs of flexion and extension views in healthy subjects. Two different observers made fifteen successive measurements of each MRC for each spinal segment. Frequently encountered positions of the MRC in healthy subjects: stress films were obtained in 51 healthy subjects aged 18–40 years. For each spinal segment, the MCR was determined with the computerized system.

Results: Accuracy of the angle measurements: the precision was 1.4° for a 95% interval of confidence. Reproducibility: variability of the position in X and Y for the MRC (expressed in percent of the size of the vertebral body) was: 19.6 and 24.5 for C2–C3; 112 and 15.3 for C3–C4; 7.7 and 9.4 for C4–C5; 9.1 and 9.4 for C5–C6; 13.1 and 11.8 for C6–C7. Positions frequently encountered in healthy subjects: the most frequent position of the MRC varied from one segment to another. There was a frequent position for each segment. These frequent positions were situated in the posterosuperior quadrant of the subjacent vertebra for C2–C3, C3–C4, C4–C5, and C5–C6. For C6–C7, the frequent positions for MRC were at the level of the intervertebral space, behind the center of the disc.

Discussion: The software tested here appeared to provide good measurements for cervical spine from C3 to C7. At these levels, the measures were accurate and reproducible, as were the coordinates for the MCR of each segment. The frequent positions of the MRC found in this study are the same as reported by other authors. This method is easy to apply in routine practice.


Patrick TROPIANO Marie-Laure LOUIS Thierry MARNAY Dominique POITOUT

Purpose of the study: The theoretical advantage of a disc prosthesis compared with fusion is to preserve spinal mobility. The purpose of our study was to determine the relationship, at nine years follow-up, between range of motion and clinical outcome after lumbar disc replacement.

Material and methods: This retrospective analysis concerned the clinical and radiographic outcome observed in 38 patients who had undergone one- or two-stage disc replacement surgery (51 implanted prostheses). Mean follow-up was 8.6 years (range 6.9–10.7). Clinical outcome was assessed with the Stauffer-Coventry modified score (SCM), the Oswestry score (ODQ) and a visual analog scale (VAS) for lumbar and radicular pain. Flexion-extension range of motion (ROM) was measured on the upright films (Cobb method) at last follow-up. Each clinical element was compared with the ROM (Spearman coefficient of correlation). Two groups of patients were distinguished: high (> 5°) and low ≤ 5°) ROM for comparison with the Mann-Whitney test.

Results: The Spearman coefficient of correlation disclosed a weak to moderate but statistically significant association between ROM, lumbar VAS (r=−0.35, p=0.034), ODQ (r=−0.33, p=0.046), SCM (r=0.42, p=0.0095); but no significant correlation between ROM and radicular VAS (r=−0.12,p=0.48). Patients with greater ROM had better clinical results and ODQ (mean difference 6.3 points, p=0.031) and SCM (mean difference 2.2 points, p=0.017); but no significant difference between the preoperative characteristics in each group (age, sex, weight, surgical history, lumbar and radicular pain, ODQ and SCM).

Discussion: There are no data in the literature comparing range of motion and clinical outcome after lumbar disc replacement. The present study demonstrated a weak to moderate but statistically significant relationship (r=0.35) between range of flexion-extension motion and clinical outcome at nine years. In addition, patients with lesser ROM (< 5°) have slightly less favorable results compared with those with greater ROM (> 5°). This study suggests the preservation of motion has a positive effect on mid-term clinical outcome.

Conclusion: These results need to be confirmed with long-term prospective data comparing discal prosthesis with fusion and non-surgical treatment in order to demonstrate the usefulness of preserving motion on the quality of the clinical outcome.


Thierry MARNAY Patrick TROPIANO Marie-Laure LOUIS

Purpose of the study: Discal arthroplasty is warranted as a part of the treatment of discopathy to guarantee mobility after disc removal. Depending on the type of discopathy, the diseased disc can be classified into different categories: absence of herniation (H0), disc herniation (H1), recurrent disc herniation (H2), post discectomy syndrome (H3), or stenosis of a single unit (including grade 1 degenerative spondylolisthesis) (St-SPd). The purpose of this study was to compare clinical outcome after discal arthroplasty for these different clinical situations.

Material and methods: This was a prospective study of 152 patients who underwent a single-stage operation for insertion of a lumbar disc prosthesis. Pain was assessed with a visual analog scale for the lumbar level (VAS-L), and for radicular pain (VAS-R) and the Oswestry index (ODI). Patients were classified as follows: 39 H0, 52 H1, 22 H2, 29 H3, 10 ST-SPd).

Results: Outcome in patients in groups H0, H1, and St-SPd, i.e. first-intention surgery patients, presented equivalent results for lumbar and radicular pain and for function: VAS-L and VAS-R declined concomitantly. Results at three months postop were equivalent to those observed at 24 months. Patients in groups H2 and H3 who had had prior operation(s) for posterior discectomy experienced rapid relief of lumbar pain but radicular pain persisted postoperatively (6 to 12 m).

Discussion: These data confirm the excellent results obtained with single-level disc replacement as assessed by VAS and ODI. The persistence of radiculalgia which then resolves several months later in patients with a history of discal surgery can be explained by the combination of chronic compression, postoperative adherences and restored disc height. In the present series, none of the patients required complementary surgery for posterior radicular release.

Conclusion: Discal arthroplasty provides satisfactory results for the different stages of discal disease. The procedure should however be undertaken with prudence for patients who have had prior surgery. A perfect analysis of other factors involved should be helpful in chosing the most appropriate technique and avoid the development of postoperative radiculalgia. The present results could be usefully confirmed with a long-term randomized prospective study comparing discal prosthesis with fusion for the treatment of discal disease.


Olivier RICART Jean-Marie SERWIER

Purpose of the study: The endoscopic transforaminal approach to the lumbar disc proposed by A.T. Yeung has achieved world-wide acceptance. The Yeung endoscopic spinal system (YESS) used with a specific instrument set enables direct magnified optical control of discectomy performed under local anesthesia and neurolepanalgesia in the outpatient setting. We began our experience in 2003 and report here the results obtained in a consecutive series of 100 patients reviewed retrospectively.

Material and methods: The inclusion criteria were patients with lumbar disc herniation-related lumbosciatic or crural pain non-responsive to well conducted medical care (including epidural or periradicular injections) for at least three months. The patients also had to display a concordant clinical and radiographic picture with confirmation of the symptomatic level by discography. Exclusion criteria were: excluded herniation with a fragment which had migrated into the canal; caudia equina syndrome; lower limb paralysis with muscle force scored less than 3; advanced-stage degernerative central bony stenosis affecting the clinical expression; pregnancy. The levels treated were: L3–L4 (n=6), L4–L5 (n=72), and L5–S1 (n=22). Herniation was forminal and extraforaminal in 53 cases, posterolateral in 31, and median in 16. There was an associated constitutional central stenosis in ten cases and in thirteen others, herniation was a recurrence after conventional surgery.

Results: One hundred patients were reviewed at mean 18 months (range 12–34 months) follow-up. There were no serious neurological, vascular, or infectious complications. According to the McNab criteria outcome was good for 71 cases, fair for 16 and poor for 13 with 11 requiring revision with conventional surgery. Patients with foraminal and extraforminal herniation accounted for more than half of our series and responded best to treatment (84.9% good outcome) compared with posterolateral herniation (48%) (p< 0.05). Patients with median herniation had an intermediary outcome (68% good results). The least satisfactory outcome was observed at the L5–S1 level (63% fair and poor outcome), but the difference did not reach statistical significance compared with the higher levels. In patients with recurrent herniation after conventional surgery, there were four cases of failure.

Discussion: These results are less satisfactory than those found in the literature. This might be explained by the less satisfactory outcome obtained with posterolateral herniations, probably because more than halve had migrated, generally above the plane of the disc, which in our experience cannot be accessed via the transforaminal approach. In addition, comparison of our first 50 cases with the last 50 showed an improvement in outcome to a mean 82%, expressing a learning curve for this type of technique. The most frequent error early in our experience was to insert the working endoscopic canula too anteriorly compared with the disc. The point of insertion must be very lateral determined by the discography in order to enter at least 30° posterior to the posterior part of the disc. Progressive fine-tuning of patient selection also helped improve outcome. YESS improves the work of the intradiscal instruments which can be control by direct view, explaining the the better results compared with the older mechanical or automatic (blind) methods. YESS is a very effective alternative to chemonucleolysis since papaine is no longer available. Compared with other endoscopic techniques for disectomy via an interlaminar approach, YESS offers the possibility of treatment patients in an outpatient setting with a local anesthesia. In addition the quality of the visual control of the foramen is better. These methods can be used in association with intradiscal Holmium-Yag laser which can also be applied to the bony walls of the foramen for a widening foraminoplasty. This transformainal endoscopic approach also offers a way to perform an exclusively foraminoscopic spondylodesis using an intersomatic cage.

Conclusion: YESS is an excellent technique for non-migrated subligament posterolateral foraminal and extraforaminal herniations where conventional access to the foramen is known to be very difficult.


Olivier RICART Jean-Marie SERWIER

Purpose of the study: The surgical treatment of degenerative lumbar stenosis associated with degenerative lumbar spondylolithesis (DLSP) is generally treated by decompression of the neurological structures combined with fusion. Results have been superior compared with decompression alone. We opted for decompression combined with stabilization without fusion using the Dynesys® in order to limit the morbidity related to instrumented fusion in older patients and to avoid the progressive aggravation of the lithesis.

Material and methods: This was a prospective series of 25 patients with symptomatic DLSP. Inclusion criteria were: saccoradiculographic confirmed degenerative stenosis of the canal associated with static anteroposterior intervertebral translation measuring at least 3 cm in the upright position irrespective of the degree of displacement demonstrated on the stress images. Incomplete reduction of the anteroposterior translation in extension, osteoporosis, associated deformity in the frontal plane were not considered to be contraindications for Dynesys® instrumentation. Exclusion criteria were: complete uni- or bilateral arthrectomy, history of lumbar surgery involving the olisthesic level. The series included 19 women and 6 men, mean age 71 years (range 53–83). All 25 cases involved the L4–L5 level. Twelve single level (L4–L5) and 13 two level (L3–L5) instrumentations were performed. All patients had a CT scan and saccoradiculography and 12 had an MRI. Pre- and postoperative stress images were obtained using the Putto protocol. Whole spine weight-bearing images were also obtained to study pelvic and sagittal parameters before and after surgery. The Beaujon classification was determined at minimum 12 months follow-up (mean follow-up 22 months, range 12–48 months).

Results: Outcome was very good in 72% of patients (relative gain > 70%) and good in 28% (relative gain 40–70%). There were no fair or poor results (100% good or very good results). There were two complications: on patient whose preoperative crural paresia worsened before complete recovery and on neuroaggressive pedicular screw which had no later consequence. The radiologic study revealed four case with an antelisthesis reduction but generally the displacement persisted and did not worsen over time. The stress films confirmed the presence of residual mobility of the instrumented level when the disc height remained sufficient. A lucent line around a screw was found in two cases with no clinical expression. After instrumentation with the Dynesys®, sagittal tilt at T9 due to accentuated lordosis below the instrumentation was observed, even in cases with an spine unbalanced anteriorly.

Discussion: This prospective study can be validly compared with another prospective study we performed in 1999 in which we compared the outcome after isolated canal decompression for DLSP with that after decompression combined with fusion. Using the same evaluation criteria, the results after fusion in a comparable population (18 patients) were similar to those observed in the present study where good and very good outcome was achieved in 88% of patients. Stabilization with Dynesys® provides results at least as good as arthrodesis with lesser perioperative morbidity.

Conclusion: In our opinion, it would be rational to propose this method for DLSP patients aged less than 65 years with a self-reducible predominantly angular displacement and satisfactory disc height. This context (group 3)occurs for pelvi with a small sacral slope and incidence, and minimal lordosis adapted to the pelvic parameters. Dynesys® is a palliative alternative to fusion for more advanced DLSP with anterior imbalance when fusion would technically difficult to correct for the kyphosis or with in a patient with significant surgical risk. Longer follow-up would be needd to confirm these good results over time and to demonstrate that Dynesys® «protects» the adjacent levels against degeneration (stenosis, destabilization).


Olivier DELATTRE Antoine COUSIN Claude SERRA Choukry DIB Octavio LABRADA Jean-Louis ROUVILLAIN Yves CATONNÉ

Purpose of the study: Three-bone arthrodesis, described in 1997, is designed for radiocarpal osteoarthritis with mediocarpal extension. The procedure consists in a capitolunohamate fusion after resection of the scaphoid and the triquetrum. It is associated with carpal shortening proportional to the degree of preoperative wrist stiffness. The objective is to achieve less stiffness than with four-bone fusion.

Material and methods: To verify our hypothesis, the first 24 patients (25 wrists) were reviewed with mean 5.2 years (2–8.5 years) follow-up. All wrists were painful and stiff, and presented radiocarpal and mediocarpal osteoarthritis. There were twelve SLAC III, nine SNAC III and four SCAC III. Mean age was 59 years (range 37–79 years). Mean preoperative range of motion was 50.5° flexion-extension (range 10–105°), mean force was 17 kg (range 10–35 kg). Radiological assessment was performed preoperatively and at last follow-up to determine the Youm index (carpal height) and the Bouman index (carpal translation) and to study the radiolunate joint space.

Results: At last follow-up, all patients had improved but one. Ten wrists were pain free twelve caused some pain at forced wrist movements, and two caused pain daily but at a level below the preoperative level. One patient still suffered from severe pain and required revision for total radiocarpal arthrodesis. The final mean flexion-extension range of motion was 67.8°, for a 13.3° gain in extension and a 3.8° gain in flexion. Ulnar inclination was improved 14° on average. Mean force was 24 kg (73% of healthy side), for a 40% improvement over the pre-operative force. RAdiographically, there was one case of capitolunate nonunion. The radiolunate space remained unchanged. Carpal height decreased 15% on average and the Bouman index increased from 0.90 to 0.93 with no significant ulnar misalignment on the carpus.

Discussion: For pain and force, these results are similar to those achieved with four-bone fusion. The overall results for range of motion are however better for flexion-extension and unlar inclination. In our practice, we have decided to replace the four-bone technique by three-bone fusion because the outcome is a less stiff wrist with a simpler surgical technique. Better results are obtained for stiffer wrists which achieve a significant improvement in motion due to carpal shortening.


Eduardo ZANCOLLI

Lesions of the fibrocartilaginous triangle of the carpus (FCTC) and lunatopyramidal (LP) instability are the most frequently treated situations involving ulnar instability of the wrist. Most publications to date have examined results obtain for the treatment of isolated lesions, few have reported associated injuries. Outcome could be better in terms of pain relief: 25–64% of pain-free results for the treatment of FCTC and unpredictable results for the treatment of LP instability.

Considering the column theory proposed by Navarro-Taleisnik we have developed a concept based on fixation of the pyramidal and an adaptation of the Mayfield lines (where kinetic energy is considered exclusively on the ulnar side); we present here what we call the «peripyramidal ring lesion».

In our series of surgical cases, pain-free outcome for combined ulnar lesions treated as FCTC lesions was achieved in 48% of cases. For cases treated as LP instability, the rate was 71.4%. Many combinations are underdiagnosed: pyramidal-median hamate, pyramidal-pisiform. By treating these combined lesions we have increased the rate of excellent results from 64% to 91% for FCTC and obtained 86% pain-free wrists for LP instability.


Sami ZOUAOUI Jean-Albert OUELLET Rudy REINDL Peter JARZEM Vincent ARLET

Purpose of the study: We report a series of 12 patients who underwent surgery in 2003 or 2004 for spinal shortening as treatment for thoracic or lumbar metastasis.

Material and method: This series included seven females and five males, mean age 56.5 years (range 34–80 years). The operation was a resection of the vertebral body in a one-stage procedure. A simple posterior approach was used for two patients and a wider costotransversectomy approach was required for ten. Posterior fixation was installed with pedicle screws in the two vertebrae above and two below the resection. Mean operative time was 343 minutes (range 260–420 min). Mean blood loss was 2380 cc (range 600–5000). There were few surgery-related complications: one dural breach and one pulmonary breach.

Results: The decision to undertake surgery was made on the basis of neurological problems in seven patients. All patients were Frankel class C, unable to walk. Among these patients, five died in less than six months. For the two survivors, they were scored 7 on the Tokuhashi scale. The remainder scored 5. For the two survivors, one recovered walking capacity (Frankel D) and the other achieved a normal status (Frankel E). The five other patients underwent surgery for pain related to a kyphosis callus threatening the cord. We used the Karnofsky and the Oswestry score to analyze outcome. The score did not regress in any of the patients after surgery. Three patients improved their score significantly. The three others had an unchanged score. The best correction of the kyphosis callus was obtained when the vertebral collapse was greater than 50%. The preoperative regional deformity was measured at 23.2° (range 15–35°) which postoperatively reached 0.5° (range 20 to −17°).

Conclusion: This technique for spinal shortening appears to be a better alternative to anterior reconstruction, especially when the vertebral collapse is greater than 50%. In this context, this palliative surgery enables improved quality-of-life for a patient with often advanced disease.


Jean-Luc ROUX Gero MEYER ZU RECKENDORF Boali AMARA Frédérique DUSSERRE

Purpose of the study: The purpose of using distal metaphyso-epiphyseal osteotomy to shorten the ulna is to reduce healing time compared with diaphyseal shortening and to adapt the osteotomy to the distal radioulnar anatomy and associated conditions by using a variably oblique cut.

Material and methods: Oblique metaphyso-eiphyseal osteotomy of the distal ulna was performed in sixteen patients since 2000. Fourteen presented ulnocarpal pain. Among these, eight had associated distal radioulnar pain. Two patients had pain essentially limited to the distal radioulnar area. Radiographically, there was ulnocarpal impingement in fourteen wrists, and signs of early-stage distal radioulnar osteoarthritis in five. Local regional anesthesia was used in thirteen patients who underwent surgery in an outpatient clinic. The dorsoulnar approach was used. The direction of the osteotomy cut depended on the individual condition, and distal radioulnar anatomy and stability. Two headless canulated screws were used for fixation. The elbow and wrist were immobilized for three weeks followed by self-education of pronosupination beginning with a removable orthesis to stabilize the wrist.

Results: Outcome was assessed at maximum follow-up of four years. Preoperative pain had totally resolved in fourteen wrists with residual pain at forced pronosupination in two. Wrist motion was not modified in the frontal and sagittal planes. Complete pronosupination range of motion was achieved in thirteen patients, two patients had supination limited to 20° and one had pronation and supination limited to 30°. Force was 90% compared to the opposite side. Bone healing was achieved in all patients, in 3–4 weeks for fourteen wrists and after two months of elbow and wrist immobilization in two.

Discussion: Oblique metaphyso-epiphyseal osteotomy of the distal ulna reduced the healing time compared with diaphyseal shortening osteotomies. This technique enables adaptation of the direction and orientation of the ulnar cut to the individual distal radioulnar anatomy. Favorable clinical outcome in patients with early-stage distal radioulnar osteoarthritis has led us to progressively abandon certain indications for distal resection of the ulna and the Sauvé-Kapankji operation.


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Alfredo OLAZABAL

We distinguish three phases of rheumatoid arthritis:

the phase of hypertrophic synovitis;

the phase of joint disorganization;

the phase of joint destruction.

During the synovitis phase, expansion of the synovial membrane leads to changes in the neighboring tissues with distension of the joint capsule and ligaments and destruction of the cartilage tissue. Tumefaction and increased volume of the tenosynovial membrane interferes with tendon gliding, giving rise to limited motion and pain. As the phase advances, tendon tears may appear because of invasiveness of the tenosynovial tissue. Surgical treatment during the synovitis phase can include synovectomy or tenosynovectomy.

During the phase of joint disorganization, capsule and ligament distension induce the deviations and instabilities characteristic of rheumatoid arthritis. The basic objective of surgery is to realign the joints and restore the anatomic relations.

Cartilage is lost during the phase of joint destruction and surgical reconstruction is the only option (arthroplasty, arthrodesis) but with inevitable loss of function.

Wrist lesions should be treated before more distal joints. The principle of repairing the most proximal joint first applies for the entire upper limb.

For the dorsal aspect of the fingers, injury to the extensor system gives rise to three characteristic deformities: mallet finger, swan-neck finger, and button hole finger. A detailed knowledge of the extensor system is needed to better understand the origin of these deformations. Briefly, the extensor system is composed of three tendon elements: the lateral bands, the median bands and the common tendon, and two retinacular elements: Landsmeer’s oblique retinacular ligament and Cleland’s transverse retinacular ligament.

The objectives of surgery are:

achieve pain relief;

improve function (motion, stability);

prevent disease progression; and

improve the aesthetic aspect.


Mario RODRIGUEZ-SAMMARTINO

Purpose of the study: The purpose of this presentation was to focus on the situation where rotator cuff tears are associated with nerve injury and to clarify the clinical nosology of the shoulder triad (glenohumeral dislocation, acute cuff tear, and circumflex nerve injury) and of the «dead shoulder syndrome» (chronic massive cuff tear, acute glenohumeral dislocation, and circumflex nerve injury).

Material and methods: This series included seven patients with the shoulder triad and five patients with dead shoulder syndrome who were treated in our department between 1996 and 2002. There were nine men and three women, aged 50–74 years (mean 58 years). Follow-up was two years or more. The Neer and Cofield classification was used to assess functional outcome and the simple shoulder test (SST) was recorded.

Results: For the patients with the shoulder triad, outcome was excellent to satisfactory in all, with frontal and vertical elevation greater than 90°, nearly normal rotations, and acceptable force and range of motion for daily, occupational and sports activities. The patients with dead shoulder syndrome were a more heterogeneous population. Clinical outcome was less satisfactory although there was a real improvement in range of motion. Occasional pain was reported and some of the patients were satisfied.

Conclusion: Combined lesions of the shoulder create a difficult diagnostic and therapeutic situation. As when occurring alone, it is important to recognize injury early in order to adapt treatment to achieve functional improvement.


Vincent PIBAROT Olivier GUYEN Jean-Marc DURAND Jean-Paul CARRET Jacques BÉJUI-HUGUES

Purpose of the study: The rate of intra and postoperative complications is generally high after surgery for neurogenic paraosteoarthropathy, also termed hetero-topic ossification.

Material and methods: We present a series of 60 cases of osteoma involving the hip joint, analyzing complications in comparison with data in the literature.

Results and discussion: Vascular complications (n=7): one required suture of the common femoral artery, three ligature of the deep femoral artery, two ligature of the deep femoral vein and one ligature of the collateral branches of the deep femoral vessels. Mean intraoperative blood loss was 1300 cc. None of the vascular complications gave rise to death or amputation. Early septic complications (n=4): three occurred after simple resection of the ossification and cured after surgical revision and antibiotics with no major impact on joint motion; one occurred after a procedure for resection of the ossification plus total hip arthroplasty and led to ankylosis of the hip joint but cured after surgical revision and prolonged antibiotic therapy. Sepsis was favored by a long hemorrhagic surgical procedure in patients at risk. Neurological complications (n=0): such complications are greatly feared but rare. Posterior ossifications expose the sciatic nerve to injury but generally displacement the nerve rather than enclosing it in the osteoma. Fracture complications (n=1): the outcome was favorable, both in terms of bone healing and joint motion. A classical complication mentioned in the literature and synonym to recurrent ossification or invalidating residual stiffness. Most are favored by ankylosis, osteoporosis, immobilization and a particularly dynamic surgeon. Recurrences (n=6): all were posttraumatic with a delay from accident to surgery ≥ 18 months.

Conclusion: Complications are related to the localization of the osteoma (relations with nerves and vessels), associated osteopathy, and the complete or partial joint stiffness. Preoperative imaging (x-rays and computed tomography with contrast injection) should localize the osteoma, keeping in mind that certain localizations create preferential conditions for certain risks. An analysis of the topography of the paraosteoarthropathy should enable the surgeon to choose the most appropriate approach. Intraoperatively, risk assessment can usefully anticipate complications which always compromise functional outcome.


Fredson RAZANABOLA Frédéric FARLIN Pascal BOIREAU Thierry FABRE Alain DURANDEAU

Purpose of the study: Basal joint osteoarthritis remains one of the most invalidating degenerative diseases of the upper limb. Most patients are women and the main symptom is pain. Several surgical approaches can be used: total trapeziectomy with or without a ligament reconstruction for intermetacarpal stabilization associated or not with tendon interposition (possibly with a synthetic insert); cemented or non-cemented trapezio-metacarpal prosthesis and arthrodesis. The purpose of this work was to report our experience with the modified Eaton-Littler technique and determine the current contribution of total trapeziectomy – ligament reconstruction – tendon interposition.

Material and methods: We report a series of 26 patients who underwent surgery between 1994 and 2002 for trapezium resection associated with intercarpal ligamentoplasty and «anchovy» interposition using a flexor carpi radialis hemi-tendon. The series involved 21 patients, 16 women and 5 men, with invalidating basal joint osteoarthritis unresponsive to medical treatment. The Dell classification was stage II and III. Mean age was 58.6 years. Five patients underwent surgery on both wrists. One patient had had a prior operation on one side and a Swanson implant on the other. The mean follow-up was 66.1 months (range 25–131 months).

Results: For these 22 cases, outcome at last follow-up was satisfactory with complete resolution of pain, excellent joint mobility with a mean Kapandji score of 9.5/10 (range 8–10). Half of the wrists exhibited deficient pinch and grasp force. Mean postoperative force was 20 kg (range 8–28 kg). Radiographically, scaphometacarpal collapse was nearly complete in all cases. For four cases, outcome was considered poor because of nearly constant pain with reduced mobility and a mean Kapandji score of 5/10. Three patients developed a reflux dystrophy: one of these patients achieved a final satisfactory result. There had been no revisions at last follow-up.

Discussion: All the proposed techniques appear to give good results in terms of pain relief. Trapiezectomy with ligamentoplasty appears to provide good results at mean six months follow-up, results which are reliable and sustained over time. Trapezio-metacarpal prostheses give good immediate results in selected patients but the rate of failure at mid-term remains high, mainly due to loosening. Second generation cemented prostheses are promising. Trapezial implants have specific complications. Trapeiometacarpal arthrodesis gives good stability of the thumb column and is particularly indicated for young active patients with less consideration on the esthetic aspect of their hand, keeping in mind the significant rate of nonunions.

Conclusion: Despite the significant progress achieved with trapeziometacarpal prosthetic arthroplaasty, we still believe that complete resection of the trapezium with ligament reconstruction associated with tendon interposition remains the gold standard in terms of patient satisfaction and reliable results for the surgical treatment of basal joint osteoarthritis.


M. Benaouda BENMANSOUR Nicolas VIX Patrick NGOUNOU

Purpose of the study: We report the results of a prospective series of 104 cases of carpal tunnel decompression using a minimally invasive technique performed by one operator.

Material and methods: The 92 patients (28 men) were treated in an outpatient clinic between February 1999 and July 2002. Mean age was 50 years and 86% of the cases involved the dominant side. Twenty-one patients were manual laborers. There was a notion of repeated motion (occupational disease) in nine cases and eight patients were diabetics. Nocturnal paresthesia predominated the clinical presentation in all patients. Anesthesia of the median nerve territory was noted in five patients. There was no motor deficit. The technique consisted in decompression of the carpal tunnel under local anesthesia via an incision in the flexion fold of the wrist and introduction of a pre-moulded canulated probe into the carpal tunnel then section of the anterior retinacular ligament using a n°15 lancet guided by the probe. Patients were reviewed at 15 days, then one, three and six months.

Results: Outcome was excellent or good in 97.2%. One patient was partially relieved: this diabetic patient retained decreased sensitivity in the median nerve territory but the nocturnal paresthesia resolved completely. Two patients underwent decompression on both sides (same technique) and continued to complain about pain on one side. There were no neurological, tendinous, or infectious complications and no conversion to open surgery was required. Mean duration of sick leave was 22.3 days and daily activities were resumed without pain at the base of the hand on average 15 days after surgery.

Conclusion: The results obtained with this minimally invasive non-endoscopic technique are comparable with endoscopic techniques but at a lesser cost.


Thomas BAUER Alain LORTAT-JACOB

Purpose of the study: When infection occurs on solid bone tissue, the problems which arise concern filling the bony defect, achieving effective antibiotic therapy at the bone level, and correct cutaneous coverage. We present our experience in the management of 80 cases of bone infection on continuous bone tissue of the lower limb.

Material and methods: This was a retrospective series of 80 cases of bone infection on continuous bone in the lower limb in 77 patients, mean age 45 years. The infection had on average persisted for 13 years and the patients had undergone on average six operations at the infected site. Bone infection was a posttraumatic complication in three-quarters of the cases and localized in the tibia in half. The general and local status was assessed for each patient using the Cierny-Mader classification. All patients underwent surgery using the same operative protocol: resection, filling, bone cutaneous cover. We describe the different operative phases and the techniques employed. Patients free of clinical or biological signs of recurrent infection two years after hospital management were considered cured.

Results: All patients were reviewed, there were no patients lost to follow-up. At mean follow-up of four years, 81% of patients were considered cured. Recurrent infection was observed in 14% of cases, requiring revision on average two years after initial management. For 5% of the cases, the initial treatment failed and was followed by amputation. Poor general or local status and extensive diffuse osteitis were factors predictive of poor cure of the infection.

Discussion: We discuss the different causes and pathogenic mechanisms of osteitis on continuous bone. Surgical techniques are compared. Bone infection on continuous bone is an ideal indication for muscle or fas-ciocutaneous flaps for filling bone cavities and achieving cutaneous cover. The different modalities and duration of antibiotic therapy are discussed.

Conclusion: Bone infection on continuous bone is a specific often poorly individualized clinical situation. A specific surgical protocol is indicated to fill bony defects, and achieve cutaneous cover and thus definitive cure.


Abdelghani MENADI Francis CHAISE Philippe BELLEMERE Mourad MEHALLEG Rabah ATIA

Purpose of the study: Infection is a leading cause of morbidity and mortality in sickle cell anemia children. It often triggers an acute episode of anemia with thrombosis. Bone and joint infections are particularly frequent. Diagnosis can be difficult and is sometimes established late.

Material and methods: We analyzed retrospectively the cases of 39 children with sickle cell anemia who presented one or more bone and joint infections during a six-year period (January 1998-December 2003).

Results: Bone and joint infection involved 14% of all sickle cell children hospitalized during the study period. Mean age was nine years, with no gender predominance. Homozygous subjects were more exposed to infection (73%). The infection revealed the disease in 13% of the children. The rate of bone and joint infection was 62% compared with 38% for osteomyelitis; salmonella were isolated in 38% of cases. Medical treatment with adapted antibiotics and plaster cast immobilization were instituted in all cases and associated with surgical treatment in 25% (arthrotomy for evacuation of purulent collections, cleaning, resection of infected tissue). Outcome was favorable in 77% of cases (cured infection, resumed school activities).

Discussion: The frequency of bone and joint infections in sickle cell anemia children in our series was similar to that reported in the literature (10–19%). Compared with children with normal hemoglobin, bone and joint infection in sickle cell anemia children present specific features in terms of localization, blood chemistry findings, causal bacteria, radiographic signs, and therapeutic modalities and sequelae.

Conclusion: Sickle cell anemia is a serious hereditary disease. The risk of complications should lead to the development of preventive measures (screening at risk couples, institution of a prenuptial certificate, allogenic bone marrow graft).


M’Barek IRRAZI Jocelyne SELLIES Aboubekr BERRICHI Patrick BEAU Nicolas IONESCU Christian CUNY

Purpose of the study: Surveillance of operative site infections (OSI) is a persistent problem in orthopedic surgery. In France, a specific administrative directive was issued on December 29, 2000 to regulate surveillance of OSI.

Material and methods: Based on evidence reported in the literature, the efficacy of any surveillance plan requires a sufficiently dense data base obtained by long-term and systematic registration of all significant information concerning all orthopedic surgery patients. Of particular importance are the ASA score, Altmeier, and antibiotic prophylaxy. During the five-year period from 1999 through 2004, a total of 8811 consecutive orthopedic surgery procedures were followed prospectively. Infections detected were registered using a dedicated software. The hospital hygiene committee and the referring surgeon performed the follow-up.

Results: On average, infection developed four months after surgery. The rate of infection was 1.2% in 1999 and declined to 0.6% in 2003 with the implementation of a few prophylactic measures. It was possible to determine which operations and which patients were at risk using as criteria the type of operation and the ASA score.

Discussion: Surveillance of OSI, with adjustment for risk factors, enabled a measurement of the risk of infection and enabled us to recognized a trend within our department. This study enabled us to define the level of risk for our patients and also develop a new preventive policy. Our findings led us to modify certain practices. Certain data reported in the literature concerning antibiotic prophylaxy were confirmed.

Conclusion: This work demonstrated the importance of following operative site infections, disclosed the implications for medical and hospital personnel, and demonstrated the efficacy of preventive measures for decreasing the rate of these infections.


Eric SENNEVILLE Hugues MELLIEZ Yannick PINOIT Laurence LEGOUT Marc SOENEN Eric BELTRAND Carlos MAYNOU Henri MIGAUD

Purpose of the study: Because of its specific properties, linezolid (LZD) is an alternative to glycopeptides for the treatment of BJI causes by resistant Gram-positive cocci. The efficacy and tolerance of long-term (> 28d) administration remain to be determined with precision.

Material and methods: This was a retrospective analysis of the files of patients who received long-term LZD for BJI with a post-treatment follow-up of at least twelve months.

Results: Between January 2001 and December 2003, 68 patients (mean age 54.6 years) received LZD (600 mg/12h) intravenously then orally for a mean duration of 14.6 weeks on average (range 6–36 weeks). The orthopedic implants were infected in 31 patients (45.6%, 27 prostheses and 4 external fixators). A fistulization was diagnosed in 29 patients (42.6%). Medical and surgical treatment was undertaken in 51 patients (75%). Germs isolated from deep samples were staphylococci (n=57, 51 meti-R), and strepotococci (n=11). A polymicrobial infection was recorded in six patients (8.8%). Clinical success was achieved in 52 patients (76.5%) at the end of treatment, a result which was sustained for 48 of them to mean follow-up of 16.8 months (range 12–48). Sixty-three episodes of side effects were noted: anemia (n=29), peripheral neuropathy (n=9), nausea (n=14), headache (n=2), neutropenia (n=2), and thrombopenia (n=1), leading to discontinuation of LZD in 23 patients (33.8%) on average 11.9 weeks (range 6–36) after onset of treatment. Fifteen patients (22.1%) required transfusion.

Discussion: Among the patients in this series with BJI, most caused by a multiresistant germ, the rate of success was satisfactory (48/68, 70.6%) with LZD. Treatment was associated with a high frequency of serious adverse effects leading to discontinuation in one-third of patients.

Conclusion: Long-term treatment of BJI with LZD appears to be effective, including in patients with infected orthopedic material. Conversely, tolerance problems can limit is use to infections caused by mul-tiresistant Gram-positive cocci unresponsive to other compounds.


Alain VANNINEUSE

Purpose of the study: Patient satisfaction is an important element for patient claims. What is the correlation between patient satisfaction and clinical scores?

Material and methods: An independent investigator reviewed the files of patients who underwent exclusive Chopart arthodesis from 1990 to 2000 and who had at least one-year follow-up. Nineteen patients were reviewed using the AOFAS scale. Patient satisfaction as assessed with two scales, a numerical scale from 1 to 10 and a verbal scale noted 1 to 4. Correlations were made with the perception of the disability due to the operation.

Results: Fourteen patients exhibited good correlation between the clinical outcome and their level of satisfaction. Five displayed clear divergence: three poor clinical scores with a high level of satisfaction and two good clinical scores in unsatisfied patients.

Discussion: The mean scores were around 6/10. Clinical assessment and satisfaction noted on a scale of 10 gave good agreement: the way satisfaction is approached and the patient’s expression of satisfaction may have an important impact. A visual scale with no semantic connotation would be les subject to interpretation since the assessment is made on a numerical scale independently of psychological implications. Conversely, the disability/satisfaction relationship was scored on a four-point scale and demonstrated rather good agreement as did the relationship between disability and clinical score. Five patients exhibited significant divergence showing that the cultural element and collateral factors (comorbid conditions) could be involved.

Conclusion: Establishing a pertinent satisfaction scale is a difficult task because the correlation with the clinical outcome is imperfect. This analysis demonstrated that less than satisfactory objective results can be associated with an acceptable level of satisfaction (three patients in this series). This situation is observed in patients aged over 60 years who grew up in an environment where the physician was to be respected and where complaining was not acceptable. This is a cultural factor. Poor appreciations which contrast with a rather average clinical result are related to collateral conditions which explain such behavior. Patient satisfaction is a multifactorial phenomenon. Reliable information collection before the operation should be helpful in allowing the patient to fine-tune expectations concerning the surgical outcome and the reservations to be expressed.


Jacques-Henri CATON Charles NEDEY

Purpose of the study: Thromboembolism is a serious complication after hip surgery. The residual rate of venous thrombosis has varied according to the type of screening used with rates reported from 3.54% to 54.2% without prophylaxis. These discordant figures led us to conduct a prospective study devoted to thromboembolic complications.

Material and methods: This prospective study was conducted from April 1995 to April 1996 in 61 consecutive patients who underwent total hip arthroplasty under general anesthesia. Duplex Doppler was performed systematically on day 8 to 10 to search for thromboembolic complications. Results of this study were compared with those of a study we conducted in 2960 total hip arthroplasties implanted from 1950 to 1999 where search for thromboembolic complications was guided by the clinical presentation.

Results: Clinical screening for thromboembolic complications in the series of 2960 total hip arthroplasties revealed a rate of 3.54% [pulmonary embolism (n=46), phlebitis (n=95), heparin induced thrombopenia (n=14)]; the rate of anticoagulant accidents was 2.5%. Associating these anticoagulant accidents with the cases of heparin induced thrombopenia, the rate of these complications was 2.97%, almost the same as that of thromboembolic complications. Duplex Doppler screening on day 8–10 detected venous thrombosis in 36.8% of patients.

Discussion: Thromboembolic complications with clinically detected phlebitis confirmed by duplex Doppler were observed in 3.54% of our series of 2960 operated patients, but systematic screening with duplex Doppler found a ten-fold higher rate, 36.8%. Should duplex Doppler be performed systematically in the postoperative period? What would be the cost, and the cost-effectiveness? It is known that when phlebitis is detected, anticoagulant treatment must be continued for at least three months postoperatively. In addition, the cases of phlebitis detected by duplex Doppler are generally distal, with no clinical expression; so what would be the benefit for these patients of long-term treatment? Considering the expenditures involved in 1000 total hip arthroplasties treated preventively with low-molecular-weight heparin, the cost of systematic duplex Doppler screening would lead to a supplementary cost of 456000 euros, without counting the cost of treatment for complications due to the anticoagulant treatment.

Conclusion: In our opinion, systematic duplex Doppler screening is not warranted. We believe that clinical screening is a valid procedure, in line with evidence provided by duplex Doppler performed in symptomatic patients. Anticoagulant treatment should be continued for six weeks after the arthroplasy as a preventive measure and should be initiated 12 to 24 hours after the operation. Systematic ultrasound screening is only useful in high-risk patients or when thrombosis prophylaxis cannot be instituted.


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Ricardo TITO-AMOR

Progress in diagnostic tools had enabled a more precise assessment of fractures of the talar neck. We discuss classifications based on magnetic resonance imaging which have provided an important aid for preoperative planning.

We recall here changing attitudes concerning the treatment of these fractures as well as their classification based on surgical anatomy. Details of the surgical technique are also discussed and the postoperative phase described.

This work is completed by comments on complications we have observed in our experience, focusing on the social cost of these complex fractures, their treatment and outcome, and the unpredictability of the disability caused by fractures of the talar neck, even after perfect reduction.


Alain VANNINEUSE

Purpose of the study: Why is a surgery patient satisfied, or not satisfied? What is the basis of the patient’s perception of the surgical result and what criteria does a patient use to decide to undergo surgery and then to consider the result satisfactory or not?

Material and methods: All patients consulting a surgeon in the orthopedic and traumatology surgery department during the month of April 2002 received an anonymous questionnaire. The inclusion criteria were an open orthopedic or traumatologic surgical procedure performed by the consulting surgeon, the last procedure performed being considered. Patient satisfaction being multifactorial, several associated factors were tested: pain, comfort, operating room, personnel, anesthesia.

Results: Twenty-five questionnaires were collected. One questionnaire was eliminated because of missing data. Operations were undertaken for medical reasons, rarely patient comfort. Postoperative patient satisfaction depended on the patient-physician relationship, and secondarily on outcome. Responses to open questions illustrated that the key element was a quality relationship with the physician.

Discussion: This survey had a methodological bias: non-responders often avoid mentioning poor outcome. In this survey, non-responders were non-consulting patients who were not tested. The remarkable fact was that the surgeon was the key to patient satisfaction, more than the result of the operation. The way information was delivered had a primordial importance: the patients expected to be given honest and pertinent information.

Conclusion: The feeling of competence and the information delivered are certainly two of the most important points in the patient-surgeon relationship. They are the cement leading to a confident relationship. Information delivery has a personal aspect which each surgeon must manage honestly. The obligation of information delivery is necessary from a regulatory point of view. But it is most important to keep in mind that the way information is delivered is an important aspect which can be assessed via an internal audit. The British National Health Service has demonstrated the usefulness of such audits and the publication of the results as well as the impact on the clientele.


Sabina CHAMPAIN Christian MAZEL

Purpose of the study: The results of arthrodesis are often described in the literature by giving the rate of complications and the rate of fusion, but with little information on how the x-rays were assessed qualitatively. The purpose of this retrospective study was to ascertain how useful quantitative radiographic analysis is in evaluating the results of lumbosacral arthrodesis.

Material and methods:The study population included 53 patients who underwent lumbosacral arthrodesis after lumbar discectomy. Clinical data and scores were noted. Sagittal and flexion-extension x-rays of the lumbar spine were obtained at mean five years follow-up. Films were also collected from a group of asymptomatic patients. The quantitative biomechanical analysis was performed with a dedicated software after image digitalization. Spinal, pelvic and vertebral parameters were compared with standard values. The kinetic behavior of the lumbar spine was assessed by recording the intervertebral mobility (IM), and the localization of the rotation centers. Residual mobility of an instrumented segment was considered absent (solid fusion) for MI = 0–3, low (doubtful fusion) for MI = 3–5), and present (nonunion) for MI > 5. The values obtained were compared with statistical tests.

Results: Values recorded for lordosis and pelvis parameters were normal. At last follow-up, solid fusion was noted for 81% of cases, doubtful fusion for 15% and nonunion for 4%. Estimated fusion was correlated with clinical results (r=0.8) and was in agreement (87%) with the surgeon’s qualitative assessment. The adjacent levels presented decreased mobility in 40% of cases and long-term degradation in 17%. The position of the rotation center was normal in 50%.

Discussion: This preliminary study shows that analysis of the sagittal balance and lumbar kinetics provides quantitative information for outcome assessment. Calculating IM determines the residual mobility of the instrumented zone and enables a qualification of the fusion. AS a complement to IM, identifying the position of the rotation center enables a description of the kinematics of the adjacent levels.

Conclusion: Quantitative analysis enables an estimate of 4% for long-term nonunion, with fusion correlated with clinical outcome. Analysis of intervertebral mobility and the position of the rotation center is pertinent for assessment of fusion and the kinematics from lumbar stress x-rays.


Mazen MAHMOUD Abdel-Massih ABOU CHAAYA Pascal COTTIAS

Purpose of the study: The aim of this work was to study the functional and radiological results as well as any complications obtained after minimally invasive treatment of bimalleolar fractures.

Material and methods: The series included 100 fractures in 100 patients who underwent surgery between 1998 and 2000: 52 men and 48 women, mean age 47.1 years (range 17–96 years). According to the AO classification, the fractures were A:18, B:62, C:20. Osteosynthesis of the lateral malleolus was achieved with a Rush nail in 95 cases and with a K-wire in six. Closed osteosynthe-sis was achieved in 67 cases, an open procedure being used for 33 cases. Osteosynthesis was performed on the medial malleolus in 73 patients, 65 with a 3.5-mm screw, a K-wire for five, and a tutor-wire in two, all during an open procedure. The functional outcome was assessed at last follow-up using the Olerund and MOlander and the AOFAS scores.

Results: Mean follow-up was thirteen months (range 3–54 months). All fractures healed at mean eight weeks (range 6–24 weeks). At last follow-up, 90 ankles were radiographically anatomic. Mean function scores were: Olerund and Molander 73.5/90; AOFAS 85.8/100. Clinical outcome (Olerund and Molander) was excellent or good in 86 patients, poor in 12 and very poor in two. According to the AOFAS score, clinical outcome was excellent or good in 90 patients, poor in 9 and very poor in one. Considered by gender and type of reduction of the lateral malleolus, there was no difference in the distribution of the clinical outcome. There was however a strong correlation between the quality of the anatomic result and the functional outcome since poor anatomic results gave poor functional results in 80% of cases. The type of anatomic fracture had a certain importance since excellent and good results were obtained for type A fractures (94%) and type C fractures (90%) but 70% of the poor results were observed in type B fractures. There were few complications: two superficial infections, four cases of reflex dystrophy, and one thromboembolic event.

Conclusion: Compared with other operative techniques, the advantages of this method are basically linked to the ability to respond to all the different forms of bimalleo-lar fracture, irrespective of the anatomic type. The operative protocol is well established. The procedure is easy to perform and rapid and provides excellent results.


Abderahmane SBIHI François-Xavier DEHAUT Mathieu DUMONT Olivier LELUC Georges CURVALE Alexandre ROCHWERGER

Purpose of the study: Ankle sprains constitute a serious public health problem with nearly 6000 consultations daily in France. The prognosis is generally good if a precise clinical diagnosis can be established and appropriate treatment undertaken. The purpose of this study was to ascertain the pertinence of the initial physical examination which determines the treatment by correlating it with the results of a high-resolution ultrasound examination.

Material and methods: This prospective study included 23 patients, mean age 30.7 years, who were followed regularly for three months. A total of 154 ultrasound explorations were performed. The initial treatment for these patients who consulted a hospital emergency room for ankle trauma was established on the basis of the Ottawa criteria. The ankles were examined by a senior physician and an ultrasonographic exploration was performed 3.9 days on average after the first consultation in the emergency room. Standard protocols were used for the physical examination and for the ultrasonography.

Results: The initial results confirmed a lesion of the lateral collateral ligament in 91% of cases with an initial tear of the anterior talofibular ligament in half of the cases and a injury to the calcaneofibular ligament in one out of five cases. One quarter of the patients had an isolated lesion. One out of ten presented a lesion of the syndesmosis and one out of three lesions of the fibular tendons. The standard ankle examination performed by the senior physician established correct diagnosis of the precise lesion in 80% of the cases.

Discussion: Lesions of the mid food and of the syndesmosis are diagnosed clinically, ultrasonography is not contributive. The stage of the initial lesion was compared with the stage at three months: in 7 out of 10 cases, the anterior talofibular and the calcaneofibular ligaments had healed correctly. Physical examination is essential but ultrasonography provides certain complementary information at a time when the physical examination can be hindered by the pain and potentially the lesser experience of emergency room examinators.

Conclusion: In light of the evidence provided by this study, it can be confirmed that the initial diagnosis of ankle sprain established in an emergency room setting can be corrected by a physical examination performed by an experienced clinician. At the present time, it is not possible to demonstrate the specific contribution of ultrasonography for the management of ankle sprains. This would require a prospective study over a longer period and should be designed to demonstrate the relationship between injury of the fibular tendons and ankle stability.


Antoine GABRION Noomen ELFEKIH Fabrice BELLOT Joël VERNOIS Olivier JARDÉ Michel DE LESTANG

Purpose of the study: The aim of this work was to compare the long-term clinical, ultrasonographic and iso-kinetic results obtained with two approaches to repair of the torn Achilles tendon.

Material and methods: The patients were reviewed at mean six years follow-up (range 2–12 years) and served as their own control. The series was composed of two groups of ten patients. The first group underwent open suture (OS) (mean age 48 years, age range 38–64 years) and the second was treated percutaneously with Tenolig® (PCS) (mean age 43 years, age range 25–68 years). The Mann, McComis and Kitaoka scores were noted as was the distance from the heal to the ground in one leg stance (comparison with opposite side). Cybex® was used to measure the isokinetic force and an ultrasound control was performed (tendon structure, dimensions).

Results: The calf of the operated side displayed amyot-rophy compared with the healthy side in all cases of PCS (mean 2 cm, range 0.5–6 cm). The heal-ground distance was often smaller compared with the healthy side in PCS. The Mann scores were equivalent for OS and PCS. The Kitaoka and McComis scores were, on average 86 (80–100) and 94 (60–95) respectively for OS versus 82 (85–100) and 91 (60–95) for PCS. Mean caliber of the operated Achilles tendon increased compared with the healthy side for both suture techniques. Isokinetic force was 3–6% greater with OS for peak force, average force, and total work.

Discussion and conclusion: Both techniques have specific complications: recurrent tears and sural nerve injury for PCS, risk for the skin and adherences for OS. The long-term outcome after PCS of the Achilles tendon is comparable with that of OS in terms of healing quality. Recorded values are however slightly higher with OS. Our results are in line with data in the literature. OS can be reserved for particularly active patients who wish to recover maximum function.


Stéphane BOISGARD Stéphane DESCAMPS Franck THANAS Jean-Paul LEVAI

Purpose of the study: Bearing wear debris from total hip arthroplasty (THA) appears to be the main cause of prosthetic loosening. RSA is the most accurate for measuring THA wear. It is the gold standard but remains difficult to use in routine practice. We therefore developed a computer-assisted method for measuring wear on plain x-rays. The purpose of this work was to determine the accuracy and reproducibility of MPH Wear 4 for measuring bearing wear.

Material and methods: The accuracy of measurements were assessed on several types of new implants or implants worn by movement simulators. X-rays of these implants were taken after implantation using a phantom simulating soft tissue and radiographic deformation. Accuracy was defined as the difference between the measurement produced by the computer-assisted tool and the reference metrology. Reproducibility was studied on ten x-rays of THA in ten patients (five men and five women, mean age 77.9 ± 4.4 years). Intraobserver reproducibility was studied with ten successive measurements on the same image by the same observer. Interobserver reproducibility was studied with a series of ten measurements on ten different images by two observers.

Results: The accuracy of the method was 0.09 mm on average (range 0.06–0.13 mm). The standard deviation giving the intraobserver reproducibility was 0.005 (i.e. 5.96% of the mean value). The standard deviation giving the interobserver reproducibility was 0.02.

Discussion: The methods used for determining the accuracy of a wear measurement system are poorly defined in the literature. It is thus difficult to compare different measurement methods. It can be considered that methods displaying an accuracy less than or equal to the mean annual polyethylene wear can be retained since they can easily identify significant wear (from the third year on). Our method is easily applied in routine practice, retrospectively if needed, offering an adapted accuracy and good reproducibility. However, this method is currently applied to cemented acetabular implants. The software is currently being adapted for study of implant migration and metal-backed implants.


Thibaut LEEMRIJSE Frédéric ENGLEBERT Jean-Jacques ROMBOUTS

Purpose of the study: Frequently described in pediatric orthopedics, supramalleolar osteotomies are theoretically logical in adults, but relatively little studied.

Material and methods: Supramalleolar osteotomy was performed for misaligned callus formation or secondary osteoarthrtitis of the ankle joint in fourteen patients in our institution since 1987. Among these fourteen patients, nine were reviewed, of which three underwent surgery for misaligned callus of the distal third of the tibia measuring more than six degrees and asymptomatic at the time of surgery. The six other patients suffered pain with associated tibiotalar osteoarthritis for four. These six patients also underwent surgery. The nine patients were reviewed clinically and radiographially.

Results: Mean follow-up was 53 months (range 6–202 months). Mean time to bone healing measured radiographically was 12.2 weeks (range 9–18 weeks). The difference in time to healing between closed and open wedge osteotomies was not significant (p=0.1, Student’s test). The difference in the preoperative AOFAS score compared with the last follow-up score was statistically significant (p=0.01) with an improvement in the AOFAS pain score (p=0.03). Function scores of open and closed wedge osteotomies were not statistically different (p=0.5). In the four patients who presented ankle osteoarthritis at the time of surgery, there was no postoperative progression of the joint degradation. Conversely, in two patients whose joint was free of signs of osteoarthritis at the time of surgery, stage I signs appeared. These two patients were reviewed at 46 and 202 months respectively from the osteotomy which in both cases had been performed to prevent the supposedly deleterious effect of a distal tibial callus misaligned 10°.

Conclusion: Open and closed wedge supramalleolar osteotomies are the preferred procedure for distal tibial callus misalignment measuring more than 10° with the reservation that the underlying joints are sufficiently mobile, the advantage of osteotomy over arthrodesis being closely related to this factor. Arthrodesis might however be considered if joint pain predominates the clinical picture.


Patrick VIENNE Ralf SCHOENIGER Naeder HELMY Christian GERBER Norman ESPINOSA

Purpose of the study: Chronic lateral instability of the ankle is often associated with residual varus deformity of the rear foot and exaggerated plantar flexion of the first ray. Several surgical techniques have been described to treat this problem, but recurrence can occur if all the components of the instability are not corrected. The purpose oft his work was to present was to present a new diagnostic and therapeutic approach to the treatment of recurrent lateral instability of the ankle.

Material and methods: Eight patients with talipes cavovarus(9 feet) were treated for recurrent chronic instability of the ankle. All patients had undergone at least one prior procedure to stabilize the rear foot and suffered persistent pain as well as subjective ankle instability. Mean age was 25 years. All patients underwent a calcaneal osteotomy for lateralization and transfer of the long fibular onto the short fibular ligament, with an additional Bronström ligament reconstruction in four cases. Clinical and radiological follow-up was 37 months on average.

Results: All patients were very satisfied. The AOFAS score improved from 58 points preoperatively to 97 points (max 100 points) at last follow-up. Postoperative alignment of the rear foot was considered physiological in all cases.

Conclusion: Recurrent chronic lateral instability of the ankle is often associated with chronic misalignment of the rear foot, leading to gait disorders and persistent pain. Ligament insufficiency, varus misalignment, and over-solicitation of the long fibular should be investigated and treated with an individually adapted surgical procedure in order to correct the recurrent instability. The results of this approach have been very promising and have been associated with very strong patient satisfaction.


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Ricardo Tito-Amor

In this article, a definition of metatarsalgia is followed by an analysis of factors involved: biomechanical alterations, diseases of the forefoot and general diseases with an impact on the forefoot.

This is followed by a brief recall of the historical background and a description of the pathological anatomy and determining anatomic and biomechanical factors.

The frequency, symptoms and differential diagnosis are discussed together with the clinical, radiological, ultrasonographic and magnetic resonance imaging findings.

Conservative and surgical treatments are proposed together with a detailed description of the procedures and the supramalleolar anesthesia used in our department.


Henri MIGAUD Yannick PINOIT Stéphane HERENT Marc SOENEN Fallah BACHOUR Olivier MAY Philippe LAFFARGUE Alain DUHAMEL Patrick DEVOS

Purpose of the study: In order to evaluate the influence of prosthesis design and resurfacing on the outcome of total hip arthroplasty (THA) implanted without cement, we reviewed the orthopedic literature from 1980 to 2004.

Material and methods: The PubMed database was screened from 1980 to 2004 for publications reporting cementless THA with a follow-up analysis. The same criteria were used to screen three registries. In all, the publications retained had studied 50,162 cementless THA (mean patient age 48.9 years, mean follow-up 6.5 years) where were studied according to rate of revision, presence of osteolysis, and presence of operative fractures. Eleven families of components grouped together the majority of prostheses: five acetabular families [screw fixation without resurfacing (n=2997), screw fixation with hydroxyapatite (HA) resurfacing (n=3618), screw fixation with corindon resurfacing (2360), press-fit mac-roporous (15691), press-fit HA (6094)]; and six families of femoral pivots [straight macroprous (n=7502), straight HA (n=3255), straight corindon (n=6136), anatomic HA (n=3468), anatomic macroporous (n=1215), anatomic corindon (n=1041)].

Results: The rates of revision and of osteolysis were higher for screw fixed cups without resurfacing. For screw fixed or press-fit cups, HA resurfacing did not reduce the rate of revision compared with corindon coated or macroporous implants. For anatomic pivots, adjunction of HA resurfacing reduced the rate of revision but at the shortest follow-up and without reducing the rate of osteolysis. Corindon-coated pivots gave comparable results for straight or anatomic implants. Conversely, HA-coated pivots gave better results with an anatomic design. The shape of the pivot had les effect than resurfacing on osteolysis and revision, but had a greater influence on operative fractures (2.9% for straight implants versus 4.6% for anatomic versions).

Conclusion: In all:

uncoated implants should be abandoned;

HA resurfacing does not reduce the rate of revision and can be associated with a higher rage of osteolysis;

there is no advantage between screw fixed or press-fit cups as long as the cup has a quality resurfacing;

there is no real difference between straight and anatomic pivots except that intraoperative fracture can be lower for the straight implants.


Toshihisa KAJIWARA Laurent VASTEL Jean-Pierre COURPIED

Purpose of the study: The purpose of this prospective study was to compare insert wear radiographically at minimum three years comparing crosslinked (Duration, Howmedia) versus regular (Stratec Medical) polyethylene.

Material and methods: We used two types of UHMWPE for a series of 140 total hip arthroplasties (THA) (February 1999 – August 2000). Duration polyethylene (Howmedica) was used for 63 implants. This UHMWPE undergoes gamma ray treatment under nitrogen which leads to a stabilization phase under temperature and time conditions enabling preferential formation of cross links between the molecular chains. Vecteur Orthopedic polyethylene implants exposed to gamma radiation under air were used for 62 implants. Eighty-seven patients were reviewed at minimum three years radiological follow-up. This series included 60 women and 27 men, mean age 64 years (range 32–93 years). The trans-trochanteric approach was used in all cases for insertion of a Charnley-Kerboull cemented femoral stem. All cups were cemented (abnormal implant position was an exclusion criterion). Cups were assigned randomly with a permutation table. Wear measurements were made by graphic construction comparing the immediate postoperative and last follow-up anteroposterior pelvis x-rays.

Results: Follow-up was at least 36 months for 87 patients. Mean follow-up for these 87 patients was 49.9 months. Mean wear was 0.32 mm for crosslinked poly-ethylene and 0.35 mm for regular polyethylene. Five patients presented wear ≥ 1 cm for crosslinked poly-ethylene and there were nine patients with ≥ 1 cm for regular polyethylene.

Discussion: In vitro, crosslinked polyethylene exhibits significantly improved mechanical qualities for wear resistance. Several factors can account for differences in polyethylene wear: the size and composition of the prosthetic head, and patient gender, age, activity level and BMI. These factors were comparable in our two groups. It does however appear that even with crosslinked poly-ethylene, after four years implantation, wear is limited, close to the detection level of the measurement method.

Conclusion: The measurement method used in this prospective randomized study of polyethylene wear comparing crosslinked versus regular polyethylene showed no difference between the two groups at four years follow-up.


Philippe ADAM Rémi PHILIPPOT Sophie COUMERT Frédéric FARIZON Michel-Henry FESSY

Purpose of the study: The double-mobility concept was introduced for clinical applications for total hip arthroplasty in 1976. The concept preserves joint range of motion while increasing stability. In this study we evaluated the consequences of these advantages in terms of polyethylene wear, measuring wear both on the concave and convex surfaces and volumetrically.

Material and methods: Forty polyethylene inserts were explanted and analyzed. Explantation had been performed for mechanical or septic failure after eight years implantation on average. Mean age of patients at implantation was 46 years. After examining the gross aspect of the insert, surface analysis was performed with direct measurement of changes in the curvature using a BHN 706 position sensor for the inner concave surface and lateral projection for the outer convex surface. Estimated measurement error was ±5μm for each method; the manufacturer's tolerance for production of the inserts was 50μm. Volumetric wear was determined by reference to the manufacturer’s data. Student’s t test for paired series was applied.

Results: At gross inspection, all inserts had lost the strips originally present on the convex surface; 40% presented visible wear of the retaining ring. Mean annual wear (± standard deviation, SD) obtained with the measuring system was 9±9 μm/yr) for the convex surface and 73 ± 69 μm/yr for the concave surface. Total annual wear, the sum of inner and outer surface wear, was 82±72 μm/yr. The mean volumetric wear was 28±28 mm3/year for the convex surface and 25±23 mm3/year for the concave surface and 53.4±40 mm3/year for total wear.

Discussion: Total wear for these 40 double-mobility inserts which had functioned in vivo was not greater than the values reported for the metal-polyethylene bearing with 22.2 mm femoral heads. The double mobility is not associated with greater wear. While there was no significant difference between the wear volume of the convex versus the concave surfaces, the differentials wear were widespread, which can be considered to result from functional differences.


Moussa HAMADOUCHE Paul BERVEILLER Franck ATLAN John-M. MARTELL Jean-Pierre COURPIED

Purpose of the study: The purpose of this propsective randomized study was to evaluate wear resistance of cemented polyethylene cups with the same design but regular or crosslinked polyethylene.

Material and methods: This series included 144 first-intention arthroplasties implanted between July 2000 and July 2002 in 137 patients (92 females, 45 males), mean age 66.2 years (range 16–88 years). The same femoral piece ws used in all patients with a 22.2 mm head. The cup was made of highly crosslinked polyethylene (Durasul™, Zimmer) for 83 hips and regular polyethylene (Duration™, Stryker) for 61 hips). The main outcome criterion was penetration of the femoral head into the cup at two years minimum follow-up (associating true wear and creep) measured with the Martell method modified by the cup manufacturer’s recommendations. Influence of patient-related factors and surgery-related factors was assessed. Non-parametric statistical tests were applied.

Results: The two groups of patients were not significantly different preoperatively. Two patients in the Durasul™ group died at 14 and 31 months follow-up. Median follow-up for the 137 survivors (142 hips) was 28.8 months (range 3–48.8 months) in the Durasul™ group and 24.8 months (ragne 0–47.9) in the Duration™ group. Among these 142 hips, 66 in the Durasul™ group and 51 in the Duration ™ group were reviewed clinically and radiographically with at least two years follow-up. The median penetration was 0.104 mm/yr in the Durasul™ group and 0.242 mm/yr in the Duration™ group (Mann-Whitney test, p=0.01, power 78%). There was a highly significant negative correlation between follow-up time and wear in the Duration™ group (Spearman r = −0.4, p=0.005) but no significant correlation in the Dursul™ group (Spearman r = −0.2, p=0.06).

Discussion and conclusion: The results of this series indicate a notable reduction in wear for highly cross-linked polyethylene cups, with no specific material-related complication. Mid-term results would however be necessary to validate these findings.


Philippe ADAM Rémi PHILIPPOT Farouk DARGAI Sophie COUMERT Frédéric FARIZON Michel-Henry FESSY

Purpose of the study: Double mobility prostheses are increasingly popular. Evidence in the literature demonstrates greater efficacy for the treatment and prevention of prosthesis instability. Ten-year survival is to the order of 95% (Aubriot, Philippot). One of the drawbacks is the risk of prosthetic head displacement outside the retaining polyethylene ring, i.e. intraprosthetic dislocation. We searched for factors causing this complication.

Material and methods: We reviewed retrospectively 67 files concerning intraprosthetic dislocation among a series of Novae cups (Serf) implanted from 1982. Head diameter was 22.2 mm for 59 cases, with a Pro stem (Serf) for 31 cases and a PF stem (Serf) for 36. Each type of stem has a specific neck design. All patients underwent revision surgery; the retaining function of the explanted pieces was analyzed.

Results: Mean time to the complication was 91 months; mean patient age at implantation was 54 years. Early cases exhibited macroscopically intact retaining capacity. Intermediary and late cases exhibited macroscopic wear with an oval shaped retaining ring. For three cases, intraprosthetic dislocation followed an episode of dislocation reduced under sedation. The cups measured 53 mm on average. The rate of calcification was high in this population (15 cases of Brooker grade 3 or 4). Mean survival was significantly different between the Pro and PF stems.

Discussion: Early dislocations were related to insufficient retaining capacity of the initially inserted ring. After a corrective measure by the manufacturer, this type of early complication has disappeared. Late dislocations resulted from impingement wear. Dislocation of a prosthesis with a double-mobility cup increases the risk of intraprosthetic dislocation after reduction; reduction procedures should thus be performed under general anesthesia with curare treatment. We analyzed the different parameters involved: head-neck relation, activity, periprosthetic calcification, cup diameter, resurfacing of the prosthetic neck. Observations were compared with data in the literature.


Jérôme TONETTI Carolyn ANGLIN Antony HODGSON Nelson GREIDANUS Bassam MASRI Donald GARBUZ Clive DUNCAN

Purpose of the study: Hip resurfacing with a metal-on-metal bearing gives good mid-term clinical results. The design of the femoral piece has an effect on implant longevity, as does the vitality of the underlying cephalic bone. Computer-assisted surgery has been helpful in position the implant but the choice of the best position is still empirical. Prosthesis designers recommend valgus, but with too much there is a risk of a superolaterl notch which would weaken the neck. This leads the surgeon to use a larger femoral implant, and consequently to resect more acetabular bone. Anteversion is not evaluated. The purpose of this study was test mechanically different valgus/varus, anteversion/retroversion positions of the femoral implant.

Material and methods: We implanted 15 femurs made of resin which were geometrically and mechanically identical. The following angles were tested: varus/valgus (−10°, neutral, +10°, +20°) and ante/retroversion (−10°, neutram, +10). A valgus notch (+20° and +10°) and a varus notch (−10°) were simulated. The femurs thus prepared were tested with Instron 8874. Load at failure was noted as well as the type of fracture: distance from the fracture line to the greater trochanter (FGT). Student’s t test was applied.

Results: All of the femurs fractured at the neck. The fracture was closer to the implant (FGT: 11.0 mm) for the 20° valgus implantation (p< 0.05). The displacement was lesser with a valgus notch (mean 2.2 mm) then without a notch (mean 3.3 mm (p< 0.05). The varus notch had no effect. The failure load was lower for 20° valgus (1236 N, range 1117–1356N) then for the other angles (1664N, range 1142–2113 N) with near statistical significance (p=0.08). Retroversion had no effect. Anteversion allowed greater displacement (4.1 mm) and supported greater loading (1879 N) before failure.

Discussion: This study, unlike clinical studies, did not demonstrate any static mechanical superiority of the valgus position for the femoral piece. Another study on cadaver bones is planned for confirmation. Clinical studies reflect the vitality of the trabecular bone supporting the implant, a vitality which could be stimulated by the valgus position.


Valentina GIOBELLINA Rémy NIZARD Jacques WITVOET Pascal BIZOT

Purpose of the study: The limitations of cemented fixation of alumina cups was demonstrated in 1983. At that time, a new metal-backed cup with a titanium ring for screw fixation and a massive alumina insert was introduced. Since the 1990s, the high rat of mobilization of screwed cups, confirmed by midterm studies, has led to the use of more stable cups. The purpose of this study was to follow the clinical and radiological course of screwed cups implanted for more than 20 years, evaluating the real need for surgical revision.

Material and methods: We reviewed independently a consecutive series of 117 prostheses implanted in 105 patients in 1984–1986. All patients had a screwed cup with an alumina insert, a cemented stem, and a 32 mm alumina head. We retained for study patients aged less than 65 years and excluded revision procedures or patients with prior infection. The clinical assessment was made with the Postel-Merle-d’Aubigné (PMA) score: for eight patients, all data were collected during a phone interview. Radiologically, cups were considered to be mobilized if the change in inclination was greater than 6° or the protrusion greater than 5 mm. Actuarial survival was calculated with the Kaplan-Meier method.

Results: Four prostheses in three patients were lost to follow-up before one year. Mean follow-up was 12.62±6.3 years (maximum 21 years). Fourteen patients had died, twelve had had revision and fifteen were lost to follow-up at more than one year. The mean PMA score improved from 11 preoperatively to 17 at last follow-up. Radiographically, 62% of the cups did not present any sign of mobilization. Four percent exhibited a periprosthetic lucent line around the stem. Considering all results together, four outcome categories could be distinguished: A: good clinical result and no radiological change (58.4%); B: good clinical result and presence of a radiological problem (15%); C: poor clinical result and no radiological unchanged; D: poor clinical result and radiological problem (n21.8%) (including revisions). For category B, the cups showed a 20° mobilization. For these patients, revision was not planned because of very satisfactory quality-of-life for age and activity level. All patients in category C had co-morbid conditions explaining the poor clinical result. Category D included revision procedures which had already been performed (73%) and symptomatic cup mobilizations (27%) measured at 13–31°: revision was planned for most of these patients. The 10-year survival was 82%, all revisions considered; at 15 years, the survival was 66.6%, warranting the change in acetabular fixation made in 1989. The decrease in survival from 82.5% at 10 to 66.6% at 15 years shows that this change was indeed necessity.

Conclusion: Good quality-of-life was achieved for 74% of patients at mean follow-up of 13 years. It would be useful to continue following the patients in category B to check whether cup mobilization has been arrested with a certain degree of adaptation. Furthermore, patients who had a revision were free of osteolysiss and the second operation was generally quite uneventful, usually with preservation of the stem and sometimes even the alumina head which was not deteriorated.


Olivier ROCHE Pablo TURELL Olivier GOSSELIN François SIRVEAUX Michelle DE GASPÉRI Daniel MOLÉ

Purpose of the study: The revision modular femoral prosthesis (PFM-R) (Centerpulse) uses a cone-shaped straight femoral stem with winglets for press-fit revision fixation in the femoral shaft. The risk of secondary migration further into the shaft is well known. The purpose of this paper was to assess the degree of PFM-R stem migration and to search for predictive factors in order to better ascertain the limits of this type of revision anchorage in the femoral shaft.

Material and methods: Fifty-three files (48 patients) were reviewed retrospectively at minimum none months follow-up. Mean patient age was 56.6 years. Revision was required for loosening (SOFCOT classification): grade 1 (n=5), grade 2 (n=8), grade 3 (n=17), grade 4 (n=10). For 13 hips, the implant to be replaced was not cemented (monobloc stem, infection), or a first-intention PFM-R.

Results: Mean migration was 4.1 mm (0–17 mm), less than 5 mm in 73.5% of cases. There was no correlation between migration and SOFCOT grade. Conversely, there was a significant difference in migration between the grade 1 and grade 3B and between Paprosky grade 1 and 4 (p=0.05). The degree of migration was correlated with the length of the persistent isthma (p< 0.0001), with the morphology of the isthma [conic/inverted conic (p< 0.01), conic/cylindric (p< 0.051)], with the cortical index (p=0.06), the length of the anchor wings (p=0.051), but not with the length of the femorotomy bridge. The length of the wing anchorage was correlated with the length of the persistent isthma (p=0.002) and with the morphology of the isthma [(conic/inverted conic p=0.02), cylindric/inverted conic (p=0.02)], but did not increase significantly with bridging length. There was a trend towards migration in osteoporotic bone (p=0.07).

Discussion and conclusion: Use of a straight stem for anchorage in the femur is associated with secondary migration which depends on the quality of the bone in the anchorage zone and the extent of the press-fit. The persistence of a cone-shaped or cylindrical isthma measuring greater than 4 cm associated with a cortical index greater than 45% and a long wing anchorage can provide excellent primary stability. It would be useless to use long stems since they do not increase the quality of anchorage. The absence of an isthma and the presence of osteoporosis are limitations for this concept.


Olivier GUYEN Vincent PIBAROT Gualter VAZ Christophe CHEVILLOTTE Jean-Paul CARRET Jacques BEJUI-HUGUES

Purpose of the study: An unstable hip prosthesis is a therapeutic challenge. The prevalence of revision is 5 to 26.6% in the literature. We evaluated the contribution of double-mobility implants for revisions of unstable hip implants.

Material and methods: This series was composed of 45 patients who underwent revision between January 2000 and December 2003 for hip instability (44 dislocations, 1 subluxation). The same implant was used for all patients, either for the first-intention version (press-fit or cemented), or for the revision version (press-fit). For certain patients, the first-intention implant was cemented in an armature. The series included 28 females and 17 males, mean age 66.5 years (range 36–48 years). The initial diagnosis was osteoarthritis in 34 cases (76%), dysplasia in seven (16%), osteonecrosis in two (4%), Paget’s disease in one (2%) and rheumatoid disease in one (2%). The patients had had 2.8 dislocations on average (range 1 – 10). Time from first dislocation to the first-intention operation was 45.6 months (range 15 days – 20 years). Mean time from the first-intention operation to revision was 64.3 months (range 3 weeks – 20 years). Risk factors for instability were repeated hip surgery (> 3 operations) for 13 patients, wear for seven, nonunion of the greater trochanter for five, neurological and cognitive impairment in five, and malposition in three.

Results: Mean follow-up was 25.2 months. None of the patients were lost to follow-up. Two patients died late after the operation. Among the complications observed, there were: two cases of recurrent dislocation, one case of subluxation, two cases of infection (one with favorable outcome after surgical cleaning and antibiotics the other followed by patient death), two cases of deep vein thrombosis, one case of popliteal paresia with favorable outcome, one case of delirium tremens. Surveillance was the therapeutic option for the patient with subluxation. For patients with dislocation, revision surgery was performed using the same implant. For one of these patients, the dislocation occurred following early loosening.

Conclusion: Use of double-mobility implants for prosthetic revision undertaken because of prosthesis instability provides encouraging results, with a rate of dislocation (4%) close to that observed with first-intention implants.


Miguel AYERZA Luis APONTE-TINAO Luis MUSCOLO

Purpose of the study: High quality knee stability and function after unicompartmental reconstruction is a considerable surgical challenge. Occasionally, the healthy compartment has to be sacrificed to achieve prosthetic reconstruction. Osteoarticular reconstructions using allografts enable restoration of the anatomic configuration and reinsertion of the articular structures (menisci) and periarticular ligaments. The purpose of this study was to analyze survival of unicompartmental osteoarticu-lar allografts of the knee and to assess complications.

Material and methods: A series of 40 unicompartmental osteoarticular allografts of the knee joint were performed from 1962 to 2001 in 38 patients followed for ten years on average (range 2–35 years). Reconstruction was performed after tumor resection in 36 patients (33 giant-cell tumors, 1 osteogenic sarcoma, 1 chondrosarcoma, 1 malignant fibrohistocytome) and after open fracture in two. The procedure involved a femoral allograft in 29 knees (medial for 11 and lateral for 18), and a tibial graft in 11 (medial for 4 and lateral for 7). Menisci and ligaments were attached to the allograft depending on the configuration of the reconstruction. A rigid screw plate internal fixation was used in all cases. The Kaplan-Meier survival was plotted from implantation to revision or last follow-up. Complications (local recurrence, fracture, joint collapse, infection) were analyzed.

Results: The overall survival at five years was 85%. There were eight complications in six patients: local recurrence (n=2), infection (n=2), fracture (n=1), massive resorption and joint collapse (n=1). Complications were considered as failures and a second reconstruction with a second allograft (two unicompartmental and four bicompartmental allografts) or a prosthetic allograft (for two joint collapse cases) were performed.

Discussion: Despite a high rate of revision for complications, five-year survival of unicompartmental allografts was 85%. This procedure appears to be a useful solution for massive loss of bone and joint stock limited to a single compartment.


Jacques-Henri CATON Zouaoui MERABET

Purpose of the study: Long-term outcome of Charn-ley total hip arthroplasty (THA) (more than 30 years follow-up) has demonstrated that the longevity of these prostheses is inversely proportional to polyethylene wear and head penetration into the cup. In order to limit wear phenomena, we have used since 1997 a Charnley THA with a 22.225 mm zirconia (Zr) head (Prozyr®, Saint-Gobain Desmarquet). The goal was to reduce wear and improve implant longevity.

Material and methods: We reviewed at minimum five years follow-up 62 patients with 69 THA with a standard Zr/PE bearing. These patients had undergone surgery in 1997–1999, the cup or the high-density PE insert were furnished by Centerpulse Zimmer. The measurement method correlated the Livermore technique with determination of the center of the head using the Chevrot and Kerboull method and interobserver radiological measurements made on digitalized images after magnification.

Results: At mean six years follow-up, the Postel-Merle-d’Aubigné score was 17.6 and overall anteroposterior wear at mast follow-up was 0.76 mm (0.73 mm with the Acoplot PE cup and 0.78 mm with the hybrid THA with an isofit cup). Mean wear for this series of implants was thus 0.12 mm/year. There were no fractures of the Zr heads. The rate of osteolysis was 10% with very minimal osteolysis defects, general in the Merckel spine. Wear on the same implant in a previous series operated on in 1997 was 0.40 mm at three years, i.e. also 0.12 mm/year.

Discussion: Wear was not greater with the Zr/PE bearing than usually observed with a 22.225 metal-backed PE bearing. This is in contradiction with observations by J. Allain and D. Goutallier in 1999 and with the publication by P. Piriou (SOFCOT 2003). Furthermore, we did not observe, like Hamadouche (SOFCOT 2001) major osteolytic lesions. On the other hand, we did not observe, as was shown by Wroblewsk, any decrease in the rate of penetration of the head into the PE insert. Using the same 22.225 Prozyr bearing with conventional PE and a cemented head, Wbroblewski showed in 2004 that at mean 4.3 years follow-up (range 0–8 years) mean penetration was 0.03 mm/yr.

Conclusion: Today, at five years follow-up, we have found that with a Charnley THA wear is the same with the Zr/PE as with the metal/PE bearing.


Jean-Paul ARNAUD Cédric COSTE Jean-Louis CHARISSOUX Christian MABIT Daniel SETTON Claude PECOUT

Purpose of the study: The introduction of ceramic bearings in the 1970s raised several issues, including the definition of what should be considered as a ceramic. The simplest definition would appear to refer to the periodic table: a ceramic is composed of a non-metal ion, generally with oxygen as the covalent ion. Alumina is the most commonly used bearing, and is generally considered the most reliable despite certain worrisome reports. Zirconium is also a very promising ceramic as was shown by a review of our firs 97 cases at ten years follow-up.

Material and methods: All patients were reviewed by the same investigator who was not one of the operating surgeons. The patients were classified by group according to their BLMI correlated by the Tanner curve, associated with the Charnley index and the Devane classification

Results: There were no septic complications. There was one dislocation and one head fracture. For the other patients, no revision was required nor planned. Preoper-ative Postel-Merle-d’Aubigné (PMA) score was 8.8 pre-operatively and 17.3 postoperatively. Radiographically, the Barrack, Guen, DeLee and Charnley and Brooker classifications for filling, lucent lines and periprosthetic calcifications were assessed on digitalized films with 115% magnification. Wear was measured on 250% magnification weight-bearing images two or three times more accurate than the classical Charnley Cupic, Liver-more or Ebra methods. This study found that 72% of the prostheses were free of femoral lucent lines, that 82% had no acetabular lucent line, and that wear was 0.114 mm/yr with an accuracy two or three times better than classical non-weight-bearing methods. There were no revisions for loosening and none were planned.

Discussion: These good results should be considered with caution because of the presence of one head fracture. In the event of a head fracture, use of these ceramic bearings almost always requires the use of another ceramic bearing, raising many technical, ethical, and legal problems which do not all have an adequate solution.


François LECUIRE Karim JALOUL Jérôme RUBINI Maurice BASSO Ignaki BENAREAU

Purpose of the study: The Alpina unicompartimen-tal knee prosthesis (Biomet) is an anatomic prosthesis inserted with a femoral cut, a tibial base plate made of titanium and a flat modular polyethylene insert. Cemented and non-cemented versions are available with hydroxyapatite ceramic (HAC) coating.

Material and methods: We retrospectively reviewed the radiological outcome at more than five years (fie to eight years follow-up) in a consecutive series of patients who had an Alpina HAC prosthesis with tibial fixation completed with a titanium screw. Clinical and radiological findings were recorded. Radiologically: pre- and postoperative angles, implant position, reliability of the instrument set. At last follow-up, we studied the presence of lucent lines, polyethylene wear easily measured on the flat insert, and bone remodeling around the tibial fixation screw.

Results: At last follow-up (5 to 8 years), three patients were lost to follow-up and three had died. Radiological outcome was thus assessed for 44 implants (41 medial and 3 lateral). One patient required an early total knee prosthesis (diagnostic error). Three patients underwent revision at 5–7 years (for rupture of the polyethylene insert in two very active patients, and for significant polyethylene wear in the third). Two had a revision procedure for a partial knee prosthesis and the third for a total knee prosthesis. For the 40 other patients, the following observations were made: partial lucent line along the tibial polyethylene plate with no functional impact (n=1), polyethylene wear visible but measuring less than 1 mm (n=12), remodeling around the tibial fixation screw probably corresponding to a granuloma but not threatening the implant (n=10).

Discussion: The clinical results of partial knee prostheses are well known. Mid-term radiographic results of non-cemented unicompartmental prostheses with a flat tibial plateau producing a minimal contact surface has shown: good reliability of the instrument set, excellent bony integration of the HAC-coated implants, but measurable polyethylene wear on more than one quarter of the prostheses, with two ruptures of the polyethylene insert at 5 and 6 years.

Conclusion: A study currently under way will examine finished pieces on a simulator to study wear and failure as a function of several parameters: polyethylene thickness, lateral restraint with a metal rim, presence of a basal stem fixing the polyethylene on the metal base, importance of the femur-polyethylene surface contact.


Sylvain GADEYNE Jean-Luc LERAT Bernard MOYEN

Purpose of the study: The aim of this retrospective study was to analyze the results obtained with the femoropa-tellar self-centering prosthesis and to confirm its usefulness and limitations for the treatment of femoropatellar osteoarthritis.

Material and methods: This continuous series of 57 patients, mean age 65.6 years underwent surgery fro 1986 to 2003 for implantation of a self-centering prosthesis. Most (60%) presented osteoarthritis on a dysplasic knee; others presented primary osteoarthritis (31%) or trauma sequelae (9%). Mean follow-up was 74.5 months (range 12–180 months). Functional outcome was assessed with the IKS and activity daily living (ADL) scales. The radiographic study enabled 3D analysis of the implant position.

Results: At last follow-up, the mean IKS score was 157.3/200. The mean ADL score was 73.8 (range 48.8–96.3). The IKS score gave 66.7% good and the ADL score, which takes into consideration all daily life functions, 57% very good outcome. Outcome was best in patients with trochlear dysplasia. The eleven knees requiring revision for a total knee arthroplasty (24%) had initially a narrower trochlear angle (p=0.02) and a thicker patella (p=0.02). In these patients, the initial prosthesis protruded more anteriorly (p=0.004) and the horizontal axis was greater (p=0.02).

Discussion: The results of this series are less satisfactory than in the literature, but assessments may depend on the scores used since there was a 10% difference between the ADL and IKS scores. The results were better in the group of patients undergoing surgery for osteoarthritis due to dysplasia, in agreement with De Cloedt and Argenson. Analysis of the radiological parameters enabled identification of technical errors leading to failure. A successful femoropatellar prosthesis depends basically on two factors: technical precision and patient selection.

Conclusion: These results led us to avoid widening indications for femoropatellar prostheses, which are already in our experience rather limited (2%). For us, patients aged 50–70 years with advanced-stage femo-ropatellar osteoarthritis due to dysplasia and no other anomaly and who have not responded to conservative treatment would be the population of choice. The lack of any technical problem for revision total knee arthroplasty is an argument in favor of the femoropatellar prosthesis.


Philippe HERNIGOU Olivier MANICOM Alexandre POIGNARD Gilles MATHIEU Paulo FILIPPINI Ali DE MOURA

Purpose of the study: The aim of this study was to analyze rotation of the normal and prosthetic distal femur as well as the spaces from 90 to 130 degrees flexion.

Material and methods: Torsion scans were obtained preoperatively and postoperatively for 44 total knee prostheses. The difference in femoral torsion between the pre- and postoperative image was used to assess the rotation in which the femoral component was implanted. The prostheses were divided into two groups: group I when the femoral implant was implanted with external rotation of more than 5°; group II when the femoral implant was implanted with external rotation less than 5°. A preoperative stress scan was obtained in 20 patients then repeated during the year following implantation. Stress images with knee flexion at angles from 90° to 130° were obtained. The patient was installed in the ventral supine position. 8mm scan slices were centered on the lower end of the femur, ten 50ms images were acquired during flexion movement from 90° to 130°. This enabled determination of the knee flexion axis preoperatively and postoperatively, to measure the variation in the epicondylar axis compared with the mechanical axis of the tibia between 90° and 130° flexion and finally to deduct change in the femorotibial space in flexion from 90° to 130°.

Results: The 18 total knee prostheses with a femoral component implanted with external rotation greater than 5° (group I) showed significantly greater range of flexion (p< 0.05) (mean 120°, range 110°–130°) than the 26 prostheses in group II with a femoral component implanted in external rotation less than 5° (mean 100°, range 80°–115°. For the 20 knees with stress scans, the preoperative images showed an epicondylar axis about 5° fro the mechanical axis of the tibia when the knee flexed in the 90°–130° range. After surgery, the stress scans showed that this epicondylar axis of rotation of the prosthesis-bearing knees occurred especially for knees with a wide range of flexion. The 20 knees with flexion limited to 100° did not present an epicondylar rotation axis compared with the mechanical axis of the tibia. The 15 knees with 125° flexion or more had an epicondylar axis of rotation after 90° flexion. Rotation of the epicondylar axis in relation to the mechanical axis of the tibia between 90° and 130° flexion was the consequence of a femorotibial space which changed in the medial and laeral femorotibial compartments between 90° and 130° flexion: after 90° flexion, the medial femorotibial space decreased and the lateral femorotibial space increased. This explains why movement from 90° flexion to 130° flexion was facilitated by placing the femoral piece in external rotation.

Discussion: Search for ligament balance for knee flexion above 90° is logical only if the goal is to obtain knee stability in extension and flexion at 90°. It is probably no rational if the goal is to allow the knee to reach flexion in the 120°–130° range. Ligament balance in flexion above 90° is important and should be maintained up through 130° flexion. The other solution is to empirically increase external rotation of the femoral component a few degrees in order to allow greater range of flexion.


Charaf AZMY François GABRIELLI Alain ASSELINEAU Sébastien LAPORTE Aubert BENJAMEN David MITTON Wafa SKALLI

Purpose of the study: The issue of patellar kinematics remains a difficult problem for patellar resurfacing during conventional or computer-assisted knee surgery, yet adequate knowledge is required for appropriate orientation of the patellar cut and insert positioning. The purpose of this study was to develop a non-invasive tool for in vivo kinematic analysis of the patellar tract and to compare results with the gold-standard invasive method.

Material and methods: A special experimental set-up designed for this study enabled experimental simulation of load-bearing flexion-extension cycles of the knee joint. Range of motion from 0 to 102° was imposed with a computer-controlled motor. The analysis was conduced on 14 complete lower limb cadaver specimens. Patellar kinematics was analyzed for each knee simultaneously with two systems: a non-invasive method using a low-dose stereoradiographic scan linked to a 3D reconstruction software; and the reference system using tripodes implanted on the patella and radio-opaque spherical markers. Six degrees of freedom were considered: three translations and three rotations. Sequential kinematic recordings were made by calculating the position of a patellar landmark in relation to a femoral landmark.

Results: The mean difference between the results obtained with the two systems was less than 1 mm for anteroposterior and vertical translations, greater for mediolateral translations. It was less than 2° for patellar flexion-extension, to the order of the motion itself for abduction-adduction, and to the order of 5° for horizontal tilt.

Discussion and conclusion: The non-invasive technique proposed here appears to be reliable for patellar translations and flexion, but need further improvement for tilt and adduction-abduction. This is particularly true for the 45° to 90° range of motion because of the difficult problem of determining the contours of the patella. Further developments for this tool are under way.


Stéphane AIRAUDI Jean-Noël ARGENSON Richard KOMISTEK Xavier FLECHER Jean-Manuel AUBANIAC

Purpose of the study: Changes in prosthetic design to adapt to knee flexion greater than 120 degrees can modify the bone-prosthesis fixation and also displace the femorotibial contact. The purpose of this study was to analyze mid-term results in a consecutive series of 186 arthroplasties and to examine the femorotibial kinematics in vivo.

Material and methods: A posterior stabilized cemented prosthesis with a plateau with motion limited to rotation was used. Design changes concerned: lengthening of the posterior femoral condyle, scooping out the poly-ethylene anteriorly with reorientation and change in the height of the posterior stabilization stem. The same technique was used for all patients who followed the same rehabilitation protocol. Mean age was 69 years (range 22–87). All patients were evaluated clinically with the IKS score and radiologically on the anterioposterior and lateral images. An in vivo analysis of the femorotibial kinematics in the weight bearing condition was also performed in 20 patients under fluoroscopic control with automatic 3D modelization.

Results: Mean follow-up was 40 months (range 2–5 years). Mean IKS function score improved from 34 preoperatively to 96 at last follow-up. The knee score improved from 53 on average to 91 at last follow-up. The mean flexion was 115° (range 45–135°) preop-eratively and 120° (115–145°) at last follow-up. One implant was removed for infection and arthrolysis was performed for one case of stiff joint. Radiographically: the mean postoperative femorotibial alignment was 179° (178–181°), the mean tibial slope 3.8° (0–10°°, the mean patellar height (0.8° (0.56–1°), and the mean elevation of the joint space (4.5 mm. There were two cases of progressive lucent lines in the tibial zone which were stable at last follow-up. All patients analyzed showed a mean posterior displacement of the femorotibial point of contact of 9.7 mm at flexion.

Discussion and conclusion: Changes in prosthesis design to adapt to greater range of flexion do not appear to have a negative effect at mid-term on implant fixation. The clinical flexion ranges obtained were encourageing and the correlation with kinematic results show that the degree of preoperative flexion remains a determining factor for the postoperative outcome. Posterior displacement of the femoro-tibial point of contact, observed in all patients examined fluoroscopically, certainly contributed to the good postoperative flexion.


Laurent JACQUOT Gérard DESCHAMPS

Purpose of the study: The aim of this study was to report outcome after more than six years follow-up of a series of 122 unicompartmental prostheses.

Material and methods: Cemented HLS® unicompart-mental surface-coated prostheses were implanted in 111 patients (122 knees, 88% medial and 12% lateral) between January 1995 and November 1997 by the same surgeon. These knees presented unicompartmen-tal osteoarthritis (91%) or unicondylar necrosis (9%). An independent senior surgeon reviewed 94 prostheses. Seventeen patients died and ten institutionalized patients free of complaints about their knee could not be fully assessed. Only three patients (2.7%) were lost to follow-up). Clinical data were assessed with the IKS criteria. A complete radiological work-up was available to compare preoperative images with the last follow-up results. Mean follow-up was 88 months (range 72–108 months).

Results: After the implantation, 96% of patients were satisfied or very satisfied; 84% had no or little pain. Mean flexion was 133° (range 90–150°). The mean knee score at follow-up was 86/100 (40/100 preoperatively), mean function score 77/100 (61/100 preoperatively). Mean residual misalignment was 6° (7° varus for medial prostheses and 4° valgus for lateral prostheses). Tibial or femoral lucent lines were observed for 22% of the prostheses but with no change and no clinical expression. There was one case of tibial polyethylene wear (1mm). There were eight failures (all before 24 months) with revision with a total knee arthroplasty (two infections, one overlarge component, two tibial loosenings, 3 unexplained pain). The Kaplan-Meier survival at maximum follow-up of 108 months was 93.67%.

Discussion: The prostheses implanted in this series were correct indications according to the preceding symposiums. We analyzed the clinical and radiological outcome (overall axial correction, tibial and femoral correction), failures, and reasons for incomplete results.

Conclusion: Outcome at more than six years in this series of resurfaced knee prostheses with a polyethylene plateau was good, supporting the correct choice of implant and technique. These results also enabled validation of the principle that unicompartmental arthroplasty is a valid alternative for the treatment of unicompartmental osteoarthritis of the knee joint. Analysis of the failures and the incomplete results discloses interesting avenues for optimizing the surgical technique and improving future clinical and radiological results.


CALCANEAL FRACTURES Pages 271 - 271
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Ricardo TITO-AMOR

The diagnosis and preoperative planning for fractures of the calcaneum are based on magnetic resonance imaging. This leads to a pathological classification used to predict the prognosis and detail operative techniques. Complications of this technique are discussed together with the social impact of this complex fracture.


Jacques-Emmanuel AYEL Bertrand MARCHEIX Xavier CHAUFFOUR Pierre MANSAT Paul BONEVIALLE

Purpose of the study: Elbow dislocation is a frequent traumatic injury. Management is well described. An associated vascular lesion is exceptional, but must be searched for systematically. We report a short series and describe our therapeutic strategy for these complicated dislocations.

Material and methods: Between 1999 and 2004, our emergency unit cared for 357 cases of elbow dislocation. For six, injury to the brachial artery was present. This series included four men and one woman, mean age 34.7 years. The causal trauma was a traffic accident for four, and a fall four two. The dislocation was open in three. The radial pulse could not be palpated in any of the patients but blood supply to the hand persisted in five. There was a clinically detected neurological deficit in three. After obtaining the necessary x-rays, the elbows were reduced in the emergency room. The radial pulse remained impalpable in all patients and arteriography was performed and revealed a rupture of the brachial artery in five and an arterial spasm in one. Vascular repair was undertaken in all six cases using an reversed venous graft. The elbow was stabilized with an external fixator in three patients. For the others, the elbow was immobilized for 21 days on average before remobilization.

Results: AT 23 months follow-up, the overall outcome has been average with a Mayo clinic score of 69.2 points. Only four elbows were functional. Only one patient had a pain free elbow. Stiff joint was the most frequent functional impairment: mean flexion was 111.7° with a 41.7° extension deficit. The blood supply to the hand was correct in all cases, but one of the graft bridges became obstructed by a thrombus, the distal vascularization being supplied by the collateral circulation. The initial neurological lesions recovered partially.

Discussion: Elbow dislocation with vascular injury is exceptional but must be systematically detected. Emergency management associates reduction of the dislocation, a vascular work-up and rapid surgical management of the elbow, using an articulated external fixator when necessary, to limit as much as possible posttraumatic stiffness.


Philippe MASSIN Antoine GOURNAY

Purpose of the study: The aim of this study was to investigate the influence of bone cuts on the degree of postoperative flexion for total knee arthroplassty in patients with a potential for good postoperative recovery of flexion.

Material and methods: Adobe Photoshop and Imagika were used to process lateral radiographs of a normal knee and simulate implantation of total knee prostheses using phantom images of femoral components of decreasing size as well as variations in the tibial slope (HLS system, Tornier). The femoral and tibial images were moved until the maximal flexion angle or impingement between the posterior tibial border and the femoral cortical occurred. The same types of implantations were simulated with real implants on cadaveric bones using the Ci navigation system (Depuy) to check the position of the bone pieces and the bone cuts. The different implantations simulated involved four femoral pieces of decreasing size with a constant tibial slope. Then the same femoral implant was used varying the tibial slope by 5° increments from -5° to +10°. Rollback during flexion could be regulated by the software by controlling the position of contact of the condyle son the corresponding tibial plateau.

Results: With the two methods, reducing the posterior condylar rim 3 mm decreased the flexion angle by 10°, modifying the tibial slope 5° induced a 5° variation in the flexion angle at impingement. A 10mm posterior rollback improved the flexion angle 10° and inversely. Cumulatively, these modifications can lead to a loss of 30° flexion.

Discussion: When regulating the space in flexion, it is sometime necessary to modify the tibial slope or the posterior condylar rim by increasing the posterior condylar cut. Depending on the prosthetic kinetics, this may modify the flexion angle intraoperatively, especially if these changes are combined, decrease in the tibial slope often being associated with an increase in the posterior condylar cut.

Conclusion: The technique used for the bone cuts for a total knee arthroplasty can potentially have a significant effect on the maximal angle of maximum flexion achieved by the patient.


Frédéric PICARD

Purpose of the study: Achieving correct ligament balance for total knee arthroplasty remains a serious challenge, even for the experienced surgeon. Computer-assisted surgery allows real time assessment of the knee joint behavior and gives continuous measures of HKA under stress.

Material and methods: Between January 2003 and November 2004, 25 patients with osteoarthritis of the knee joint underwent computer-assisted surgery for implantation of posterior stabilized total knee prosthesis. The series included 13 right knees and 12 left knees in 8 men and 17 women, mean age 73.6±8.1 years, age range 44–84 years. Body mass index was 29±5.5 (range 21.6–42.7). The IKS function score was 35.8±17 (range 5–70) and the IKS knee score was 51.2±8.5 (range 30–73). Measurements were made for varus and valgus stress of 0–30°. Extensive lateral or medial release was also performed for six knees. The medial parapatellar approach with removal of osteophytes was used for all procedures.

Results: Preoperatively, four patients presented valgus (185.6±4.7, range 182–191°), one correct alignment and 20 presented varus (174±3.45, range 166–178°). Pre-operatively the mean varus stress angle was 5.13±3.44 (range 0–11°), the mean valgus stress angle was 1.5±1.53, range −4 to 4°). At the end of the procedure, the varus stress angle 1.78±1.59 (0–5°) and the valgus stress angle 1.79±1.6 (0–4°). At 45 days, mean flexion was 115±10° (range 60–126°). There was mobilization in two patients, one with a 5° extension deficit and the other with an extension deficit less than 10°.

Discussion: This study demonstrates the usefulness of navigation systems to assess the effect of peripheral release and to limit the extent of release procedures (six of 25 patients). Materializing step by step release of the peripheral structures is helpful in achieving correct release.

Conclusion: This work confirms that extensive release is not always necessary. This type of technique should allow better control and fine tuning of ligament balance and tension.

This work was supported by work on cadaver specimens measuring the step by step effect of ligament release.


Miguel AYERZA Luis APONTE-TINAO Luis MUSCOLO

Purpose of the study: The objective of this work was to analyze outcome in a series of patients with bone anomalies after failed knee arthroplasty who were treated in the same institution with revision prosthesis with use of fragmented and structured bone grafts.

Material and methods: Between April 1994 and June 2004, a total of 515 knee arthroplasties were performed at the Italian hospital of Buenos Aires. Among these, 27 were revisions after failure of a primary arthroplasty. Two patients (follow-up less than one year) were excluded from the analysis. Among the 25 patients analyzed, eight were men and 17 women, mean age 67 years (range 41–87). Minimum follow-up was one year, mean 3.5 years, range 3–9 years. The cause of primary arthoplasty failure was aseptic loosening for ten knees, prosthetic infection in eleven, and pain in three and periprosthetic fracture in one. Fragmented or structured allografts were used for reconstruction in 15 patients. Reconstruction concerned the femur or the tibia after removal of the primary prosthesis. For twelve patients, a fragmented allograft was impacted and for three a combined fragmented-structured allograft was used. For 21 reconstructions, the revision prosthesis had intramedul-lary femoral and tibial stems and for 15, complementary elements were added to the prosthetic components on the femoral piece for three, on the tibial piece for four and on both for eight.

Conclusion: Use of fragmented and structured allografts combined with complementary elements offers a valid alternative for reconstruction of bone stock loss after failed primary knee arthroplasty.


Lucas REHBY Laurent JEUNET Nicolas BONIN Olivier FORTERRE Yves TROPET Patrick GARBUIO

Purpose of the study: Locked centromedullary nailing has proven efficacy for the treament of tibial shaft fractures but its use remains controversial for the most distal fractures. The purpose of this work was to assess clinical and radiological outcome of nailing procedures used to treat fractures of the lower quarter of the leg.

Material and methods: Fifty-eight fractures of the lower quarter of the leg were treated by locked centromedul-lary nailing between 1999 and 2002. All patients were included in the analysis. Twenty-four patients aged 44 years on average (range 18–68 years) were reviewed by an independent operator at mean 43.2 months follow-up (range 18–70). Four types of nail were used, on an orthopedic table for 47 procedures and with a hanging leg for 11. The fibula was not fixed.

Results: Early complications were: compartment syndrome (n=2) and infection (n=3). Postoperative alignment was anatomic or good in 86%. Mean time to weight bearing was 66 days (range 0–180). Nonunion occurred in six patients who required revision. Secondary displacement was noted in ten patients. Knee motion was normal in all patients and ankle motion was normal in 80%. Mean time to resumed occupational activity was 5.7 months (range 1–18). At last follow-up, bone healing had been achieved in all patients.

Discussion: As compared with data in the literature, we found that locked centromedullary nailing allows early weight bearing with less risk of infection for radiological results comparable with those obtained with plate fixation. The secondary displacements resulted from defective locking of inappropriately adapted materials (holes insufficiently distal).

Conclusion: Locked centromedullary nailing is a treatment of choice for fractures of the distal quarter of the leg. Use of new nails with more distal holes should improve outcome by allowing distal locking with at least two screws in all cases.


Xavier ROUSSIGNOL Gérard POLLE

Purpose of the study: We report our experience with 59 cases of secondary nailing after external fixation of tibial fractures.

Material and methods: Between 1988 and 2002, 59 tibial fractures (58 patients) were treated initially by external fixation then by secondary nailing. The AO classification was: A (n=28), B (n=20), C (n=11). The Gustilo classification was: closed (n=28), grade 1 (n=18), grade 2 (n=10), grade 3A (n=1), grade 3C (n=2). Tibiotibial or tibio-calcaneal external fixation was used initially for these lower diaphysometaphyseal fractures. The reason for using external fixation was: soft tissue damage (n=38), complex fracture (n=14), associated injuries (n=7). Associated plastic surgery procedures were: medial gastrocnemius flap (n=1), skin graft (n=3). Secondary nailing was undertaken early in 41 cases at about the sixth week because of improvement in the local or general status. For seven cases, the secondary nailing was performed at about four weeks after the multiple-fragment fracture had partially consolidated. There were three infectious complications after nailing (abscess on screw, fistula, pandiaphysistis) in patients whose initial samples of the reaming material were bacteriologically negative. Bone healing was achieved after nailing in 56 cases. Dynamizing the nail was sufficient to achieve healing in one case. Two cases of septic non-union were nailed again and finally healed. The case of pandiaphysitis was treated by removing the nail then a new external fixation which was successful in achieving bone healing.

Results: The results of the secondary centromedullary nailing were satisfactory. Several operations were necessary however (removal of the fixator, nailing, dynaiztion, material removal) with considerable risk of infection. This two-stge method enables treatment of difficult situations rapidly (external fixation) and early (four weeks) revision to allow «programmed» treatment in safer conditions. This secondary nailing can also be used as a treatment in the event of late healing after initial external fixation. Contraindications are pin tract osteitis and serious local infection during the external fixation phase.


Alejandro-José RAMOS-VÉRTIZ

Purpose of the study: The outcomes of different stabilization methods for unstable forearm fractures are described.

Material and methods: From January 1980 through December 2000, 29 patients were treated at the central military hospital orthopedics uint for proximal forearm fractures, 27 underwent surgery. We used the Beaufils classification, depending on the localization of the ulnar fracture. Type 1: metaphyseal fracture (n=12) with dislocation of the radial cup; type 2: epiphyseal fracture with transolecraneal dislocation (n=6); type 3: metaphyso-epiphyseal fracture with anterior dislocation (n=5); type 4: metaphyso-epiphyseal fracture with posterior dislocation (n=5).

Results: Outcome was assessed at six months to 20 years follow-up. According to the Morrey classification, outcome was excellent for six patients, good for nine, fair for seven and poor for three. Six patients had a stiff joint, one had a synostosis and three nonunion.

Conclusion: To achieve satisfactory outcome, it is crucial to achieve internal fixation of the proximal ulna and reconstruction of the radial length. Resection without replacement of the radial cup is contraindicated in these associated fractures.


Philippe LIVERNEAUX Matthieu BEUSTES-STÉFANELLI

Purpose of the study: Percutaneous osteosynthesis of scaphoid fractures remains a difficult technique which requires a long learning curve. Complications remain a problem, even in experienced hands of specialized surgeons. The purpose of this work was to study the potential contribution of fluoroscopic navigation for precutaneous screwing of the carpal scaphoid.

Material and methods: Right and left arm anatomic specimens from ten subjects were sectioned at the elbow level. Both wrists from each subject were prepared and each of the scaphoids was fixed by percutaneous screwing using regular fluoroscopic guidance for one and the other with fluoroscopic navigation. The regular fluoro-scopic guidance technique was used for the first wrist, selected randomly. Fluoroscopic navigation was used for the other side to achieve strict fixation of the wrist in the ideal screwing position using a stable radiotranspar-ent and flexible device. Using a calibraton grid displayed on the fluoroscope screen the system software corrected for distortions of the fluoroscope image. Reflecting patches on the surgical instruments were recognized by the 3D optical localization system. This enabled a real time screen display of instrument movement. Resolution was sufficient to align the screw with the scaphoid axis and calculate the length of the screw.

The resolution of the reformated digital images enabled real time screen display of instrument movement at a resolution which enabled pin insertion in the scaphoid axis. The length of the perforated screw inserted percutaneously over the pin was measured on the screen.

Results and discussion: Unlike the regular screwing method and excepting the image acquisition time which can be achieved without exposing the operator, exposure time to radiation was zero with fluoroscopic navigation. The duration of the operation was longer with navigation because the instruments had to be calibrated and because a learning curve is required. The quality of the screw fixation assessed on plain x-rays, computed tomography, and photographs of the entire scaphoid then sectional along the major axis after removal was similar between the two methods.

Conclusion: In conclusion, fluoroscopic navigation is a reliable technique which protects both the operator and the patient from radiation exposure. The technique remains to be standardized to shorten the learning curve, improve the navigation software, and develop a calibrated instrumentation before it can be used in routine clinical practice.


Bruno CHEMAMA Nicolas BONNEVIALLE Pierre MANSAT Paul BONNEVIALLE Alexa GASTON Michel MANSAT

Purpose of the study: Locked centromedullary nailing (LCMN) has become the gold standard treatment for fractures of the femur (I. Kempf, Chirurgie 91 ; 117 : 478 / Borel R.C.O. 93 ; 79,553 / Wolinsky J. trauma 99, 46 : 382). Nevertheless, the SOFCOT 2004 round table emphasized the frequency of complications related to inappropriate material and techniques. The series studied had several biases: multicentric recruitment, materials with different designs, high percentage of patients lost to follow-up. In order to overcome these shortcomings we reviewed retrospectively a consecutive series of LCMN performed in a single center from 2001 to 2002, attempting to be as exhaustive as possible.

Material and methods: The study group included 78 patients (81 LCMN) aged 30 years on average (range 16–87 years) with male predominance (69%). A large proportion of patients were traffic accident victims (44% two-wheel vehicles, 42% four-wheel vehicles). The fracture was open in 8% and 65% of patients had multiple fractures (11% floating knees, 23% multiple trauma). The fractures were simple (43%), wedge (47%) and comminutive (10%). Time to operation was 7.4 hr on average for 83% of patients. Mean reaming was 12 mm (range 11–14 mm). An 11-mm (range 10–13 mm) static Grosse and Kempf (Stryker) nail was used in all patients. Intraoperative complications occurred in 8% of cases with no effect on bone healing.

Results: Three patients died from severe head trauma. Five patients were lost to follow-up. Written follow-up data were available for six patients and 64 patients were reviewed clinically. Among the 70 fractures with known outcome, four had not healed (with two screw failures and one nail failure). Knee motion was normal in all patients. Anteroposterior and lateral alignment was normal (±5°) in 94% with no leg length discrepancy (< 10 mm)in 87%. The nail was withdrawn in 84% of patients and the withdrawal procedure was complicated in three cases (hematoma, screw failure). Mean hospital stay for single-fracture patients was 9.7 days for nailing and 2.2 days for nail removal.

Discussion: LCMN is a reliable technique which provides constant clinical results when applied with rigorous technique. The logistics is resource intensive. Nonunion can be revised with the same method. A new nailing with second reaming should be performed early in the event of late healing.


Eric TOULLEC

Purpose of the study: Gait in patients with severe pes planovalgus is generally compromised by the excessive medial force. The altered gait pattern affects the overall static and the opposite lower limb. Dynamic baropodometry can be used to measure the lateromedial force in pes planovalgus before and after corrective surgery.

Material and methods: This series included 26 patients (28 feet), mean age 54.4 years (range 15–75 years), ten males and 16 females. All of the patients had stage 2 pes planovalgus due to posterior tibial tendinopathy without lower limb misalignment. The emed-SF gait platform (Novel) was used to make three consecutive measurements with recording of the second step while walking on the platform. Measurements were made before and after conservative surgery for pes planoval-gus which combined lengthening of the calcaneum (Evans), systematic percutaneous lengthening of the Achilles tendon, lengthening of the peroneal tendons, and reconstruction of the medial arch by lowering the first metatarsal in most cases. The force index (lateral over medial force) was calculated by the Novel-ortho software which also displayed the curve of the force index during the step movement.

Results: The force index (lateral over medial) was 0.87 in this series of pes planovalgus (normal = 1.07). This index remained below 1 throughout the step movement for 13 of 28 feet. For the others, medial force increased uniquely during weight bearing phases: taligrade, plantigrade or digitigrade. After surgery, the index increased to 1.25 with normalization of the force index curve in 15 of 28 feet. A comparative study on the first ray was not very significant: scarf lowering (9 cases from 0.81 to 1.16), basal lowering by dorsal addition (8 cases from 0.87 to 1.14), arthrodesis of the first cuneometatarsal (5 cass from 0.89 to 1.15); three cases did not have lowering procedures with less favorable clinical results but with an index which changed from 0.75 to 1.05.

Discussion: This study enabled an assessment of the lat-eromedial balance of the planovalgus foot without misalignment of the lower limbs. We were able to show that realigning the foot lessens the stress on the posterior tibial tendon which did not always have to be repaired to achieve a good clinical result. This re-balancing of the muscle stabilizing the rear foot occurs progressively, as was noted on the successive baropodometric examinations. This points out the importance of not starting proprioceptive rehabilitation exercises before four months postop. On the other hand, active reinforcement of the toe flexors should be started early. This study was conducted with a very small sample but did show that a postoperative force index below 0.9 is a sign of under correction and that an index above 1.8 corresponds to overcorrection.

Conclusion: Functional management requires good knowledge of the pathological processes and the therapeutic implications. This study shows that baropodometry, even without footprint analysis or pressure distribution measurements, enables definition of functional parameters which can be helpful in achieving more precise management for foot and ankle surgery.


Raoul BERTIN-CASTELLAN Skander KAMOUN Pascal KOUYOUMDJIAN Philippe MARCHAND Gérard ASENCIO

Purpose of the study: Treatment of supra- and inter-condylar fractures of the femur remains a difficult challenge, irrespective of the method used, because of the high risk of infection, disassembly, nonunion, joint stiffness, osteoarthritis, and multiple operations. Use of a supracondylar retrograde nail, accepted for C1 and C2 fractures, can be used for some C3 fractures depending on the stability of the epidphyseal assembly.

Material and methods: This series included 19 C3 fractures (AO classification) operated on in 1993–2000. Mean patient age was 54 years (range 30–81), 11 females and 8 males. This consecutive series of patients had: high energy trauma (n=14), low-energy trauma (n=5), multiple fractures (n=16), open fractures (n=10). Osteo-synthesis was performed on an ordinary table in the dorsal supine position with arthrotomy and epiphyseal screw and pin fixation followed by static supracondylar retrograde nailing (Smith and Nephez GHS), completed in two cases with an autologous corticocancellous graft. Kinetec was used for mobilization and weigh bearing delayed until bone healing.

Results: Twelve secondary operations were performed: cover with muscle flap (n=1), early revision for rotation misalignement (n=1), autologous graft (n=4), surgical arthrolysis (n=6), revision for nonunion (n=4). There were no infections. Among the four cases of nonunion, three involved epiphyseal screw failure, two cases having involved grafts. All four cases were treated by decortication, graft and plate fixation; healing was achieved. Mean time to bone healing per primam was 23 weeks on average. The 19 patients were examined at mean 44 months follow-up (range 16–78 months). Pain was noted: absent (n=8), mild (n=3), moderate (n=6), severe (n=2). Gait was noted: normal (n=7), slight limp (n=9), important limp (n=3). Mean flexion was 114° (range 85–150°). Five cass had permanent flexion < 10°. Radiologically, misalignment of +5° in the frontal plan was observed in six cases.

Discussion: Retrograde nailing of C3 fractures is difficult, but possible and requires first epiphyseal fixation then diaphyseal solidarization. The assembly is reliable, allowing immediate mobilization. Weight bearing must however be delayed to bone healing. Complementary surgery to graft bone stock or for relative arthrolysis has to be integrated into the operative plane for more than half of these difficult cases.


Guy PIÉTU Denis WAAST Joseph LETENNEUR

Purpose of the study: The relative role for anterograde nailing in relation to retrograde nailing has become a highly debated issue. Bifemoral fractures would appear to be a priority indication for the later method.

Material and methods: From January 1997 to December 2003, 19 bifemoral shaft fractures were treated by simultaneous retrograde nailing (group 1, eight cases, five males, three females) or by anterograde nailing in a one-stage procedure (group 2, eleven cases, six males, five females). Patient age was 23 years 7 months on average (range 16.6–40.5 years) in group 1 and 26 years 7 months (range 17.8–42.3 years) in group 2. The ISS was 30.6 (13–50) in group 1 and 16.8 (10–27) in group 2.

Results: The time for installation of the two femurs was 30 min (range 20–40 min) in group 1 and 70 min (range 60–80 min) in group 2. The operative time for the two femurs was 144 min (range 110–170) in group 1 and 156 min (range 140–180 min) in group 2. One patient in group 1 died on day 2 postop; none in group 2. First-intention bone healing was achieved at 14 weeks (range 12–16) in all patients in group 1. In group 2, there were two nail replacements and two grafts. Healing time was 24 weeks (range 10–130). Follow-up was 24 months (range 13–54 months). Knee flexion was 138° (range 130–140°) in group 1 (removal of patellar tendon calcification in one patient) and 123° (range 110–150°) in group 2. The difference in length between the two femurs was 6.2 mm (range 0–6 mm) in group 1 and 5.3 mm (range 0–11 mm) in group 2. The functional outcome (Thorensen criteria) was excellent in nine femurs, good in five in group one and excellent in nine, good in nine and fair in four in group 2.

Conclusion: Retrograde nailing provides clinical and radiographic results which are comparable to antero-grade nailing. However, the time required and the ease of installation is in favor of retrograde nailing.


Ivan GOROSITO

In adults, supracondylar fractures of the femur occur in two age groups, young subjects victims of high-energy trauma often with associated injuries, and old subjects, generally women, victims of low-energy trauma with no other injury.

The basic problem is the difficult reduction and stabilization. Once this has been achieved, the objective is to avoid knee stiffness, nonunion, and a misaligned callus.

The goal of treatment is to restore anatomic configuration, achieve stable fixation, and allow early mobilization.

Based on work by Seligsson and Lannacone in 1993–1994, we began treating these fractures with retrograde centromedullary nailing. Our first report of 17 cases was published in 1999. We have analyzed 42 cases with mean three year four months follow-up: 40 healed at 74 days on average, with only two cases of nonunion. Knee flexion was greater than 80° in 36 patients and there were no deformed calluses. The positioning technique is easy, biological, and totally safe. There are few complications and outcome is good.

Retrograde nailing is indicated for closed or open Gustilo I-II fractures, group A and C1-2 fractures in the AO classification.

Contraindications are open Gustilo III fractures and AO C3 fractures, or fractures with a very low supracondylar localization.


Olivier JARDÉ Joël VERNOIS Georges ABI-RAAD Raphaël COURSIER Stéphanie DELELIS Arnaud PATOUT

Purpose of the study: When treating flatfoot, the objective of subtalar arthrodesis is to reestablish appropriate relations between the talus and the calcaeum by implanting a spacer. The purpose of this study was to evaluate the use of an expansion screw placed in the tarsal sinus and to assess the outcome.

Material and methods: Thirty patients with reducible symptomatic flatfoot participated in the study. There were 28 men and 2 women. Surgery was proposed because of pain-related functional disability and failure of orthopedic treatment. Mean age at surgery was 21 years. The Djian-Annonier angle was 134°. The patients were reviewed retrospectively. The Kitaoka function score was noted.

Results: Mean follow-up was four years. None of the patients wore orthopedic shoes. Degenerative joint remodeling was not observed. The overall outcome was: very good (n=20), good (n=4), fair (n=2), poor (n=4).

Discussion: Arthrorisis using a spacer positioned in the tarsal sinus is a technically simple procedure enabling significant podoscopic correction of flatfoot which persists.

Conclusion: This simple technique enables satisfactory anatomic and functional results.


Patrick VIENNE Leonard RAMSEIER Ralf SCHOENIGER Christian GERBER Espinosa Norman

Purpose of the study: Recurrent deformity in adulthood after successful treatment of clubfoot in childhood is exceptional. Patients experience subjective instability of the hindfood associated with progressive varus deformity and osteoarthritis of the subtalar joint. The purpose of this study was to analyze outcome after double arthrodesis in the specific situation.

Material and methods: Nine patients aged 41 years on average (range 18–64 years) were reviewed clinically and radiologically at mean 43 months follow-up after double arthrodesis (subtalar and Chopart). Time between the primary surgery and arthrodesis was 25 years on average (range 8–37 years). Clinical outcome was assessed with the AOFAS system. Plain x-rays were analyzed.

Results: The AOFAS score improved from 42 points preoperatively to 67 points on average at last follow-up (maximum 90 points). Improvement in pain was less pronounced, 27 points preoperatively and 13 points at last follow-up. Ankle motion did not decrease significantly. There was a non-significant progression of the ankle joint osteoarthritic degeneration in 71% of patients. Subjectively, the patients were moderately satisfied with the postoperative alignment of the hindfoot.

Conclusion: Double arthrodesis is often the only alternative for adults with recurrent clubfoot deformity causing pain and subjective instability of the hindfoot. The results in our series did not reveal any significant progression of the ankle joint degeneration at midterm follow-up of three years. Pain and subjective instability were improved, though the physiological alignment of the hindfoot could not be totally restored.


Alain FABRE Michel LEVADOUX Bertrand BAUER Edouard VAN GAVER Sylvain RIGAL

Purpose of the study: The difficulty of achieving successful reconstruction after tissue loss involving the lower third of the leg, particularly the malleolar region in septic cases, is well known. We report our experience with sequential surgery to treat open fractures of the lower leg and examine the contribution of the distally-based neurocutaneous sural flap.

Material and methods: The following protocol was used for the treatment of tissue defects involving the lower third of the leg and the ankle in 16 patients: repeated wound debridement, change in fixation system for 13 cases, rapid cover of the posterior segment of the leg with an island-dissected distally based neurocutaneous sural flap. Ten nonunions were treated later with a bone graft. Mean age in this series of 14 men and 2 women was 34 years (range 21–70 years). Thirteen patients were secondary hospitalization patients. The Gustilo classification after debridement was class IIIb. Time to cover ranged from one to eight months.

Results: Healing was achieved in three weeks. For three cases, revision was necessary due to re-activation of an infectious focus. All fractures healed (with tibiotalar fusion in two cases).

Discussion: The distally-based pediculated neurocutaneous sural flap is an interesting alternative to microanastomosis flaps for reconstruction of tissue defects of the lower third of the leg. Harvested from the posterior aspect of the calf which is generally spared, this flap must be carefully planned since there is no potential for augmenting the covering capacity. Great care must be taken to protect the pedicle; in our experience tunnelisation must be avoided. This flap also allows cover of a sterile osteosynthesis plate and resists local infection well. It can be raised easily if a bone graft is later necessary. In trauma victims, the esthetic and sensorial prejudice can be considered minor.

Conclusion: The distally-based neurocutaneous sural flap greatly contributes to our strategy for the management of tissue defects involving the lower third of the leg. Its main limitation is its size which can rarely exceed 80 cm2 in our experience.


Grégory SORRIAUX Fadi HOYEK Thomas KRUPPA Christophe AVEROUS Pierre KEHR

Purpose of the study: The communicating branch of the lateral plantar nerve is an anastomotic branch between the medial and lateral plantar nerves. Morton’s pseudoneuroma is usually described as resulting from the combination of one of the divisions of the medial plantar nerve and the communicating branch of the lateral plantar nerve. Surgical treatment of Morton’s pseudoneuroma can fail, leading to recurrent neuroma, or digital hypoesthesia. We performed an anatomic dissection study to search for the anatomic basis for an improved surgical technique.

Material and methods: The study included 35 feet of embalmed cadavers. A standard protocol was used for dissection. We studied the communicating branch, its frequency and size, and measured its attachment on the 3rd and 4th plantar common digital nerves. All other nerve ramifications were noted.

Results: None of the 35 dissected feet presented a macroscopic Morton pseudoneuroma. The communicating branch was present in 77% of the specimens with frequent anatomic variations concerning the size, ramifications, orientation and distance from the intermetatarsal ligament. A fine plantar cutaneous branch was often found under the intermetatarsal ligament. The bifurcation of the 2nd and 3rd nerves was occasions not far from the junction of the communicating branch on the 3rd nerve, raising the risk of injury to the 2nd nerve during surgical excision of a Morton pseudoneuroma.

Discussion: The communicating branch appears to play a role in recurrence after excision of the Morton pseudoneuroma by preventing the retraction of the 3rd digital nerve in the muscle zone if it is not sectioned. However, wide resection of the proximal part of the 3rd nerve and the communicating branch could lead to digital hypoesthesis if the 2nd digital nerve is injured. The proximity of the bifurcations of the 2nd and 3rd nerves and of the 3rd nerve with the communicating branch could explain this type of complication.

Conclusion: We advocate resection of the pseudoneuroma under visual control in order to carefully resect the communicating branch without injuring the adjacent nerve branches.


Stéphane LEVANTE Charles COURT Jacques-Yves NORDIN

Purpose of the study: The thin soft tissue cover and the proximity of underlying structures of the ankle are factors favoring cutaneous necrosis which could rapidly expose the bone, joint or tendons. Flap cover is widely used. Several types of flap and donor sits have been described. We report a consecutive series to examine the different indications.

Material and methods: Between 2000 and 2005, we treated 22 cases of tissue defects involving the ankle. Most patients were trauma victims with damage involving the distal quarter of the leg to the forefoot. Mean size of tissue loss was 8 x 6 cm (range 2–13 x 2–9 cm). The localization was medial for nine, anterior for six, and lateral for seven. Several types of flaps were used: distally-based sural (n10), lateral supramaleolar (n=5), medial arch (n=2), pediculated soleus (n=4), island latissimus dorsi (n=1).

Results: The success rate was 72%. There was one total failure (medial arch). The six cases of partial failure (27%), which involved partial distal necrosis of three lateral supramaleolar flaps and three sural flaps, were revised by re-advancement of the pedicle or aspirative dressings.

Discussion: When possible, we prefer pediculated flaps considered to be more reliable. The rate of partial necrosis was high but all of the failure cases involved serious general problems. The sural flap is especially useful for anterior and lateral tissue defects. Its deep pedicle is often intact, improving chances of survival. It can also be used for transverse anteriomedial injuries. Large longitudinal medial defects would be a good indication for free flaps or, in the event of a contraindication and also, in our experience, for pediculated soleus flaps. Supramalleolar flaps can be a problem in this localization: we reserve these flaps for non-traumatic medial or anterior defects. We have found that the risk of failure it too great for the medial supramalleolar flap.


Thomas BAUER Namanh Tang HÀ Françoise RIMAREIX Alain LORTAT-JACOB

Purpose of the study: We present our experience with the distal-based sural flap for lower leg tissue defects.

Material and methods: This consecutive retrospective series included 45 flaps in 45 patients, 36 men and 9 women, mean age 50 years. The size and the cause of the tissue loss were described as were the patients’ history and risk factors. The distally-based fasciocutaneous sural flap was used in all cases. The postoperative period as well as the quality of the final cover were analyzed.

Results: At mean follow-up of 45 months, 43 of the 45 faciocutaneous flaps survived. Cover of initial tissue defect was complete in 41 cases and partial in two. Two flaps failed, leading to limb amputation. For the 25 patients with no risk factor, all flaps resulted in perfect tissue cover. In the 20 patients with risk factors, perfect cover was achieved for 16; only 10 of 20 flaps had an uneventful history with simple healing process; partial necrosis developed in eight flaps and two flaps failed.

Discussion: The Distally-based fasciocutaneous sural flap is a very reliable method offering many possibilities for covering lower limb tissue loss from the upper third of the leg to the ankle and hindfoot. The limitations are patient-related. There are thus many indications. For bone infections, one stage tissue cover can be achieved by integrating the flap as part of the overall treatment for the bone-related injury. This flap has an excellent vascular supply which increases the local concentration of systemic antibiotics. The distally-based sural flap can also be used successfully in traumatology.

Conclusion: The distally-based sural flap is reliable and relatively easy to perform. It provides excellent cover for most tissue losses situated on the lower half of the leg and ankle. The limitations are patient-related.


Stéphane LEVANTE Alain-Charles MASQUELET Jacques-Yves NORDIN

Purpose of the study: Osteitis with loss of distal soft tissue on the medial aspect of the leg raises a problem of cutanous cover, particularly in the event of longitudinal injury. Free flaps are frequently used with variable success in older patients with more risk factors. Four our more frail patients, we have used a retrograde soleus flap pediculated on the posterior tibial artery. We present here the possibilities offered by this flap and assess the different indications.

Material and methods: Six patients, mean age 55 years (range 44–68 years) were treated for cutaneous tissue loss measuring 9.5 x 6.5 cm on average. One patient was diabetic and two were smokers. The decision to use the soleus flap was made because of the presence of cutaneous lesions on the leg contraindicating a local falp. Arteriography revealed the persistence of the three vascular routes with satisfactory distal anastomoses, allowing high ligature of the posterior tibial arery intraopeartiely after a clamprepermeabilization test. The soleus flap was modeled to size and rotated en bloc with the tibial artery which was released to the retromaleolar localization for the distal flap^s. Treatment of osteitis incluced resection, cement filling and antibiotics then bone graft.

Results: All flaps survived. One had to be revised because of partial necrosis. There were no distal vascular problems. At minimum follow-up of 18 months, all the cases of osteitis had healed.

Discussion: The soleus flap pediculated on the posterior tibial artery is a reliable and effective flap. The territory covered can be very distal, reaching the foot. The vascularization of the soleus muscle allows moving the entire muscle, providing a very powerful flap. Deliberate sacrifice of a vascular supply considered as dominant for the leg is certainly a difficult decision, but which must be weighed against the risk of failure of a free flap.


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Simon MARMOR Philippe HARDY Pascal GAUDIN Philippe PAILLARD Ha Nam Anh TANG

Purpose of the study: The incidence and type of complications observed with arthroscopic procedures remains a timely subject, particularly as the use of new techniques becomes increasingly widespread.

Material and methods: In cooperation with the members of ISAKOS, The International Society of Arthroscopy, Knee surgery and Orthopaedic Surgery, we instituted two studies: a retrospective study of upper limb arthroscopy complications and a prospective incidence study during a 30-day inclusion period with patient review at one month and quality-of-life scoring.

Results: The retrospective study analyzed complications of 57,604 arthroscopic procedures of the upper limb performed by 99 surgeons from 38 countries. Neurological complications, though generally transient, were the most frequent and were related to traction, locoregional anesthesia or the operative technique. Four deaths were recorded, all anesthesia-related. The prospective study included 364 patients operated on by 50 surgeons. There were 16 initial complications (4.39%): material problem (n=12), three intraoperative bleeding (n=3), atelectasia (n=1). The rate of conversion was 2.47%. At one month, there were five complications reported in 133 patients (3.75%): anesthesia-related problem (n=1), bleeding (n=1), synovial fistula (n=1), reflex dystrophy (n=2). There were no infections and no neurological lesions. The one-month outcome was considered good or excellent by 98.5% of surgeons.

Discussion and conclusion: The results of these surveys are in agreement with data in the literature where the rate of complications is higher in prospective studies than in retrospective studies. The prospective study did not disclose any neurological complication while arthroscopy of the upper limb is generally considered to raise the risk of with this type of complication. This study recalls that although arthoscopy has enabled a decreased incidence in complications compared with open surgery, it is not a benign intervention and can produce complications.


Olivier TOUCHARD Olivier ROCHE François SIRVEAUX Olivier GOSSELIN Pablo TURELL Daniel MOLÉ

Purpose of the study: Orthopedic treatment is generally proposed for minimally displaced fractures of the scapula. Surgery is indicated in the event of medialization or disorientation of the glenoid cavity. The purpose of this study was to identify rules for management of problematic cases.

Material and methods: This retrospective study included 27 patients, 22 men and five women, mean age 46.7 years (range 22–83 years). The fracture was limited to the scapula in 17 and was part of thoracic syndrome in ten. Injury to the plexus was noted in three patients. Associated lesions were noted in 55% of patients. Orthopedic treatment was proposed for 15 patients (group 1) and surgical treatment for 12 (group 2): neck osteosynthesis (n=4), clavicle fixation (n=5), combined osteosynthesis (n=3).

Results: Mean follow-up was 47.3 months; 21 patients were reviewed (four lost to follow-up, two deaths). Per primam healing was achieved for all fractures. There were no complications related to the surgical procedure in group 2 and no secondary displacement in either group. Mean time to resumed occupational activity was four months (range 0.2–25 months): 2.2 months (1–5 months) in group 1 and 5.5 months (0.2–25 months) in group 2. The age and gender weighted Constant score for the overall series was 96.2% (range 80–100%) with 81% excellent and very good functional outcomes. In group 1, the Constant score was 95.4% (81–100%) with 70% excellent and very good functional outcomes. It was 97% (80–100%) in group 2 with 91% excellent results. At last follow-up, there was only one case of Samilson grade 2 osteoarthritis.

Discussion and conclusion: The functional outcome observed after treatment of scapular fractures is satisfactory. Orthopedic treatment should be reserved for non-displaced fractures. If there is significant medial offset of the glenoid cavity or instability, osteosynthesis of the scapular neck is indicated, possibly with reinforcement by fixation of the clavicle. Isolated osteosynthesis of the clavicle stabilizes the scapular ring but does not reduce the scapular fracture.


Philippe LIVERNEAUX Arielle SALON Thierry DUBERT Rémi BLETON Jean-Yves ALNOT

Purpose of the study: We reviewed traumatic distal leg amputations managed in our unit between 1990 and 1993. Reimplantation or unilateral emergency revascularization were undertaken in five cases.

Material and methods: The initial loss of length was considerable (range 8.5–12 cm) allowing direct internal fixation, protected with an external fixator bridging the ankle, and direct vasculonervous suture. Secondary lengthening was undertaken early in the proximal metaphyseal zone before sensorial recovery was complete.

Results: Healing was achieved within a normal delay in all cases. Nerve regeneration was monitored from the site of the microsuture by following the progression of the Tinel sign along the repaired nerve trunks; this defined the rate of regeneration. Our observations showed that nerve lengthening above the site of the microsurgical suture did not hinder nerve regeneration and even appear to stimulate it.

Conclusion: This strategy of extensive initial debridement compensated for by significant but well-tolerated secondary lengthening enabled us to broaden indications for unilateral leg reimplantations. The quality of the functional results at follow-up extending up to 15 years is probably one of the reasons justifying this strategy.


Antoine GABRION Pacôme PARIZON Eric HAVET Arnaud PATOU Guy ALOVOR Patrice MERTL Michel DE LESTANG

Purpose of the study: Osteosynthesis procedures proposed for fractures of the proximal humerus have evolved greatly since the development of anterograde nailing systems with the objective of providing a conservative surgical solution for sometimes complex fractures. We analyzed retrospectively the results obtained in a consecutive series of 30 patients treated in our unit with a Telegraph® nail.

Material and methods: Between March 2001 and August 2003, 39 patients presenting fractures of the proximal humerus were treated with a Telegraph® nail. Accorrding to the Duparc classification, the fractures were: 17, 11 ST+T, 4 CT II, and 7 CT III. Five patients died before the review presented here. Four CT III fractures presented material disassembly early and required revision with a hemiarthroplasty. For the 30 patients reviewed here, we noted the Constant score and the results of the Matsen test as well as radiographic findings.

Results: Mean follow-up for the 30 patients was 16 months (range 6–33). Mean age at trauma was 58.7 years (range 19–91). The mean Constant score was 57.4 (range 16–84) with 72% after weighting. The Matsen test was positive for 59%. Subjectively, 69% of patients were satisfied or very satisfied. There were several complications: secondary intraoperative shaft fracture treated orthopedically, four nonunions of the surgical neck, four tuberosity migrations, three cases of head necrosis, two subacromial impingements (one with rotator cuff tear). Nonunion was generally observed with static locking and in one case with an oversized nail. We were unable to identify any factor predictive of head necrosis due to the small number of cephalotuberosity fractures. Disassembly was generally observed in patients with an initially displaced fracture with periosteal rupture, osteoporosis and old age.

Discussion and conclusion: Our results are less satisfactory than others published in the literature for series using this material and it is difficult to compare with results for series using other types of material because the study criteria were highly variable. Although all fractures in this series, including the most complex, appear to benefit from this nailing system, we did note that complications were not exceptional even though certain compliations observed were related to our learning curve. Surgeons should be aware that the planned option can be changed intraoperatively. Arthroplasty may be necessary in certain cases if the conditions are not adequate for stable osteosynthesis.


Christophe CHANTELOT Samuel FERRY Guillaume WAVREILLE Grégory PRODHOMME Régis GUINAND Christian FONTAINE

Purpose of the study: The latissimus dorsi free flap is widely used for reconstruction of large tissue defects. It is always difficult however to explain the procedure to the patient, particularly the potential sequelae. The purpose of this work was to assess sequelae affecting shoulder function and the esthetic aspect of the harvesting site.

Material and methods: We reviewed 16 patients (17 harvestings) aged 37.8 years on average (range 22–62 years), twelve men and four women, at mean follow-up of 4.5 years. All flaps had been harvested to reconstruct tissue defects of the lower limb. Eleven were semi-emergency procedures, four for chronic defects or reconstruction after tumor resection. We assessed the esthetic aspect of the harvesting zone and shoulder function suing Cybex 6000 (comparative isokinetic tests of the two shoulders). The Dash score was noted.

Results: Functional impairment was minimum in all patients. The Dash score was 17.5%. (compared with the opposite side was: 27% abduction, 22% extension and 10% rotation. Adduction, flexion and external rotation were preserved. The esthetic aspect was acceptable but not negligible. Obesity appeared to accentuate disgraceful scars.

Discussion and conclusion: The latissimus dorsi free flap is often indicated for reconstruction of significant tissue defect. Shoulder function is largely preserved. Patients should be informed about the major scar. The side to be harvested should be discussed with the patient, even in the emergency situation.


Lucas REHBY Philippe SARLIEVE Daniel LEPAGE Pascal CLAPPAZ Patrick GARBUIO Laurent OBERT

Purpose of the study: Reinsertion of the brachial biceps on the radial tubercle has been an effective method for recovering cyclic supination. Several surgical techniques have been proposed but only one clinical evaluation of operated patients has been published. We report the first study of a clinical and magnetic resonance imaging (MRI) assessment of brachial biceps reinsertion in the anatomic position using an anchorage system. The purpose of this work ws to determine whether the reinserted biceps remains inserted and to analyze the zone of insertion.

Material and methods: Nine manual laborers underwent surgery between 1999 and 2003 for repair of a ruptured brachial biceps by reinsertion on an anchor. The patients were reviewed by an independent operator (measurement of force and flexion). A 3-Tesla MRI machine was used to evaluate the position of the reinserted biceps. Reinsertion was performed within 5 days of injury (range 3–9 days) using the same technique of anchorage in the radial tubercle in all cases. A longitudinal incision measuring 3–5 cm along the medial border of the radial brachial was made to localize the ruptured biceps and the radial tubercle and drill two or three insertion holes for the anchors. The suture threads were used to bring the brachial biceps tendon progressively to the anchor used as a pulley before knotting. The patients were immobilized for three weeks, limiting flexion to 0–90°, then 45–130° the three following weeks.

Results: For the nine patients, there were no cases of sepsis nor radioulnar synostosis. Three cases of calcification were noted and to cases of nervous complications which resolved totally. Six patients, mean age 44.8 years (range 34–54 years) (two patients had moved away from the region) were reviewed at mean 19.2 months (range 10–33 months). Force at maximum flexion was 94.6% of the opposite side (range 58–131.5%). Repeated supination was somewhat bothersome for two patients. None of the patients complained of work impairment and all resumed their activity at the same level within 4.6 months on average. The MRI analysis (available in five patients) demonstrated that the reinserted tendon was in contact with the bone and that ther was a visible bone-tendon junction: the anterior and posterior borders of the tendon, as well as the fivers, showed a regular configuration. The terminal part of the tendon was enlarged in 3/5 cases. The tendon signal from the last 3 cm was variable: low intensity signal on T1 and T2 sequences or discrete high intensity signal on T1 and T2. There was no evidence of peritendinous effusion. At the time of the MRI evaluation, the anchors had not been resorbed.

Discussion: Several studies have reported the usefulness of reinserting the branchial biceps in manual laborers. The half-approach techniques, especially by anchorage, avoid the double-approach, enabling less traumatic reinsertion. The branches of the radial nerve must be carefully identified (we observed only resolutive cases of nervous deficit). Nevertheless, this type of reinsertion has not been evaluated. There is no proof that the reinserted biceps remains in an anatomic position. Our MRI findings are in favor of continuing the single-strand suture technique since the evidence demonstrated the validity of this type of transosseous suture.


Pascal CLAPPAZ David GALLINET Laurent OBERT Daniel LEPAGE Séverin ROCHET Patrick GARBUIO

Purpose of the study: Functional recovery afte displaced cephalotuberosity fracture of the proximal humerus in pateints aged over 70 years is a major surgical challenge. Reconstuction with an inversed prosthesis avoids the problems of tuberosity fixation. We report a prospective consecutive series of reversed prostheses used of 3 and 4 fragment displaced and non-displace fractures in patients aged over 70 years.

Material and methods: Between January 2001 and June 2004, 19 patients aged over 70 years were included in this study, 16 women and 3 men, mean age 74.9 years (range 58–94 years, median 76 years). All presented 3- or 4-fragment fractures. An independent operator established the Constant and Dash scores. The position of the implants, loosening, presence of a glenoid notch (Nerot) were noted on plain x-rays.

Results: Sixteen of the 19 patients (13 women, 3 men), mean age 73.9 years (range 58–94 years) were reviewed at mean 12.6 months follow-up (range 6–18 months). There were no cases of dislocation. Hematogenous sepsis occurred at 16 months in one patient and led to implant removal. The raw Constant score was 53 (34–76) and the weighted Constant score 76.1 (41–110.1). The Dash score was 37.4 (34–76). Active abduction reached 91.2° (10–150°), active elevation 97.5° (20–150°), active RE1 6.6° (0–50°), active RE2 9.4° (0–90°) and active internal rotation 31.2° (0–60°). There was a humeral lucent line in five cases and a grade 0 glenoid line in one, grade 1 and 2 in six, and grade 3 in three.

Discussion: The only series of fracture of the proximal humerus in patients aged over 70 years was a retrospective study of prosthesis patients reported by Wretenberg in 1997. To date, there has not been a published series on use of the reversed prosthesis for fracture. For the short term in a population with frail bone and minimal functional requirements, reversed implants provide the best subjective and objective functional results. The absence of postoperative immobilization and independence from the rotator cuff enables rapid recovery of useful motion. Range of motion is reduced only to a small extent for rotation. Thus when possible, we reinsert the tuberosities with the reversed implant. Even if the tuberosity assembly dismounts (agitation in a context of temporospatail disorientation), there is no consequence on the reversed prosthesis. The large number of lucent lines with no clinical impact is a point to be examined carefully, showing that further improvement can be achieved with the existing implants.


Laurent BÉGUIN Philippe ADAM Joris MORTIER Michel-Henry FESSY

Purpose of the study: The reversed total shoulder prosthesis is one of the treatments currently proposed for excentered glenoid osteoarthritic degeneration with massive rotator cuff tears. In light of the mediocre or at best highly variable results obtained with osteosynthesis or humeral arthroplasty for four-fragment fractures of the proximal humerus, indications for the reversed total shoulder prosthesis have been widened to include this category of traumatology patients. The purpose of this prospective study was to report outcome with the reversed prosthesis used for complex fracture of the proximal humerus in subjects aged over 70 years.

Material and methods: Ten patients, mean age 76 years, underwent surgery performed by the same surgeon to insert a Delta (DePuy) reversed prosthesis for four-fragment complex displaced fracture of the proximal humerus. The deltopectoral approach was used for all patients. The rotator cuff status was assessed intraoperatively. Clinical (Constant score) and radiological assessment were noted at 24 months.

Results: During the operation, only three of the ten shoulders presented a full thickness rotator cuff tear. One patients developed a complication requiring revision: early dislocation revised with a retaining polyethylene insert without recurrent dislocation. There were no cases of glenoid loosening at last follow-up. The weighted Constant score was 65/100. A pain-free shoulder was achieved in all ten patients. Anterior elevation was 130° on average, internal rotation reached hand to buttocks and active external rotation 20°.

Discussion: In patients aged over 70 years presenting a complex four-fragment fracture of the proximal humerus, the reversed prosthesis enables improved function and restoration of satisfactory joint movement. Early postoperative recovery and the gain in pain relief are encouraging factors. There was however unsatisfactory restoration of active rotation. For the elderly subject, free of a massive rotator cuff tear, rapid recovery after insertion of an reversed prosthesis should be balanced against the possible preservation of active rotations with an anatomic prosthesis.


Jean-François CAZENEUVE Alain BRUNEL Ferhat KERMAD Yasser-Laon HASSAN

Purpose of the study: Hemi-arthroplasty, osteosynthesis, and ball-and-socket implants provide well-known results for the management of displaced joint fractures of the proximal humerus in elderly subjects. The purpose of this work was to assess the reversed Grammont prosthesis for these indications.

Material and methods: From 1993 to 1999, eighteen Delta III prostheses were implanted by the same operator in recent trauma victims. The patients, 17 women and one man, mean age 75 years, presented four-fragment fractures (n=15) or fracture dislocation (n=3). The dominant side was involved in nine cases. These patients presented infiltrative rotator cuff tendinopathy (n=4), type 1 diabetes mellitus (n=2), exogenosis (n=2), morbid obestity (n=2), homelessness (n=2), and dementia (n=2). Surgery was performed under general anesthesia in the semi-sitting position via a trapezodeltoid approach without acromion osteotomy and with 20° humeral implant retroversion in all cases except one, cemented in 17 cases. The tubercles could be reinserted in four patients. Rehabilitation was not always possible. The Constant score and the anteroposterior and Lamy lateral views were used to assess clinical and radiographic outcome.

Results: There were two deaths, so the analysis included 16 shoulders. Complications were: shoulder-hand syndrome (n=1), early deep Acinetobacter infection with revision and preservation of the arthroplasty (n=1), anterior dislocation at one month due to voluntary 10° anterotation of the humeral stem requiring reorientation (n=1). At mean follow-up of 85 months, the Constant score was 60, with a weighted score of 83%. The results were not influenced by reinsertion of the tubercles and were considered good for pain and activity, fair for strength, and disappointing for rotations. The x-rays did not reveal any sign of humeral loosening. There was one lucent line between the glenoid and the metaglenoid, four cases with pillar notches, and nine infraglenoid ossifications.

Discussion and conclusion: For displaced joint fractures of the proximal humerus, endomedullary osteosynthesis and the ball-and-socket implant have shown their efficacy as an alternative to hemiarthroplasty. The reverted prosthesis also appears to be a valid therapeutic option for elderly persons with osteoporotic bone compromising the reinsertion of the tubercules. This option enables good results for pain, activity, strenth and active mobility except for rotation, with only five signs of gravity for the glenoid with one involving the glenoid and none the humerus at 85 months follow-up. These results should be further confirmed with a larger series and longer follow-up.


Laurent OBERT Grégoire LECLERC Pascal CLAPPAZ Daniel LEPAGE Nicolas BONIN Laurent JEUNET

Purpose of the study: Appropriate treatment for fractures of the distal radius with dorsal displacement remains a subject of debate. Intrafocal pinning is the most widely used technique in France. Plate fixation has been developed to avoid secondary displacement and stiffness sometimes observed after pinning. We compared three osteosynthesis techniques for the same type of fracture (extra-articular with dorsal displacement).

Material and methods: Sixty-two consecutive patients underwent osteosynthesis using the following techniques successively: posterior plates [20 patients mean age 59.9 years (range 25–87 years)], intra and extra-focal pînning [22 patients mean age 55.6 years (range17–83 years)], the anterior plate [20 patients mean age 57.1 years (range 17–78 years)]. An independent operator evaluated all patients using the Herzberg, Gartland and Werley and Dash scores. The radial slope in the frontal plane, sagittal tilt, and ulnar variance were measured and compared between the preoperative and last follow-up values. Kruskall-Wallis or ANOVA were applied as appropriate for continuous variables and the chi-square test for non-continuous variables. P< 0.05 was considered significant.

Results: Mean operative time was equivalent for the two plate fixation techniques and twice as long as for pinning. There were more complications in the posterior plating group (32%) and less satisfactory function score despite a two-fold longer follow-up and a smaller number of operators. The best results were obtained with the anterior plating group in terms of range of motion (flexion-extension), Dash, preservation of ulnar variance and presence of a largest number of excellent and very good outcomes according to Gartland. The pinning group provided the best results in terms of sagittal slope. The pinning and anterior plating groups had equivalent range of motion for supination pronation and the same rate of complications (5%). Irrespective of the treatment arm, the Herzberg scores and the Gartland and Dash scores were better: in men, in patients aged less than 30 years, in patients with an associated fracture of the apex of the ulnar syloid process rather than its base.

Discussion: While posterior plate fixation is logical (approach on the side of the injury), the technique is difficult and can lead to nerve and tendon complications. For these extra-articular fractures, pinning like anterior plating can provide good functional results. Pinning is a rapid procedure and anterior plates do not have to be removed, allowing more rapid recovery of total independence.


Abdelghani MENADI Francis CHAISE Philippe BELLEMERE Mohamed BOUCHEREB Rabah ATIA

Purpose of the study: Distal amputation of the long fingers with loss of dorsal or volar tissue may leave bone exposed requiring fingertip reconstruction to restore sensorial and tactile function. Several methods have been proposed for fingertip reconstruction. Among the methods the most widely used, thenar flaps predominate because of they are reliable and easy to perform but especially because of the very high-quality tissue function achieved.

Material and methods: We report a series of 86 patients who presented an amputation of a long finger during a 4-year period (January 1998 to December 2002). A tenar flap was constructed within 24 of the operation. Mean patient age was 26 years; 80% of the accidents were occupational accidents; tissue loss was caused by sharp instruments in 72% of the cases; three-quarters of the cases involved the left non-dominant hand; the greatest damage was to the middle finger in 58% of cases. Loss of dorsal tissue was noted for 80% of the amputations. Trunk anesthesia was used for all patients to achieve cover with a thenar flap with a proximal pedicle in 80%. The flap was weaned from its blood supply at 18 days on average.

Results: Outcome was assessed with three criteria at mean follow-up of one year. Subjectively, 80% of patients were satisfied with the operation. Permanent flexion of the distal interphalangeal joint was totally absent in 70% of patients. Using the British Medical Research Council, sensibility was scored S3 in 60% and S2 in 40%.

Discussion: Described as early as 1926, the thenar flap is a novel method for achieving a cutaneous cover very close to the anatomic fingertip. Several drawbacks have nevertheless been formulated, namely permanent flexion of the distal interphalangeal joint, cutaneous sequelae at the donor site, and the «blind» nature of the flap which can be devoid of sensitivity. Analyzing the results obtained in our series showed that harvesting a flap in the middle of the thenar zone avoiding the medial region which raises the risk of a cheloid scar, the risk of distal interphalangeal flexion can be avoided by starting active-passive rehabilitation exercises as early as possible. At two months, the fingertip starts gaining sensitivity via the periphery.

Conclusion: Thenar flaps are reliable, easy to perform flaps which provide an attractive solution to the reconstruction of long fingers.


Matthias WINTER Thierry BALAGUER Bertrand COULET Elisa LEBRETON Michel CHAMMAS

Purpose of the study: There is no satisfactory surgical solution for symptomatic osteoarthritis of the elbow joint with preserved functional motion if arthroplasty is not indicated (age, functional demand). The same is true for resistant epicondylalgia. The joint denervation techniques applied for the wrist and proximal inter-phalangeal joints have demonstrated their efficacy. We conducted an anatomic study of elbow innervation as a preliminary step to the development of a standardized surgical procedure for complete denervation of the elbow compartment.

Material and methods: The study was conducted on 15 right and left unprepared fresh cadaver specimens. A standardized dissection method was used. The terminal branches of the brachial plexus were dissected proximally to distally under magnification, from the root of the arm to the mid third of the forearm.

Results: Innervation of the medial compartment arose: anteriorly, from one of the two capsuloperiosteal branches arising from the medial nerve; in the epitrochleo-olecraneal gutter, from capsular branches issuing from the trunk of the radial nerve at the root of the arm and running with the ulnar nerve. The innervation of the lateral compartment arose: anteriorly, from an inconstant capsular branch issuing from the musculo-cutaneous nerve arising 4 to 7 cm downstream from the joint space and running between the bones. In the other cases, this zone was innervated by a nerve branch coming from the dorsal cutaneous nerve of the forearm issuing from the radial nerve. This branch innervated the apex of the laeral epicondyle in all cases. The posterior part of the lateral compartment was constantly innervated by a branch arising from the radial nerve in the proximal part of the arm, running between the deep hed of the triceps and the vastus lateralis, giving rise of nerves innervating the joint and terminating in the body of the anconeus muscle.

Discussion: Our study enabled the description of new sources of elbow innervation not reported by Wilhelm.

Conclusion: This systematization study of elbow joint innervation is a preliminary step to the development of a complete procedure for unicompartmental lateral or medial denervation of the elbow joint. The fields of application are the treatment of symptomatic osteoarthritis of the elbow joint in patients with preserved joint motion and resistant epicondylalgia.


Jean-Jacques COMTET Claude RUMELHART Laurence CHÈZE Tarek FIKRY

Purpose of the study: To our knowledge, only qualitative data is available concerning the tension placed on the first carpometacarpal ligaments as a function of joint motion. The three articles published in the literature have provided discordant data. We conducted a quantitative study.

Material and methods:

Digitalized computed tomographies of the carpometacarpal joints magnified threefold were fed to a Stratasys® machine which created a rapid «polystyrene shock» prototype of the first and second metacarpals as well as the trapezium and the trapezoid.

After a preliminary study of the behavior observed with various materials, rubber with known consistency was used to simulate the different ligaments.

The first metacarpal was submitted to six movements in defined directions starting from the neutral position (in accordance with Pieron, 1973).

Ligament lengthening observed for each movement from the resting position of the first metacarpal was used to define the direction producing the greatest lengthening. This lengthening was measured directly with a graduated ruler under 2.5 x optical magnification.

Results: The anterior oblique ligament was under tension in the positions close to extension (positions L and D). The posterior oblique ligament was under tension in the position of ulnar finger opposition and in volar abduction (positions K and F). The inter-osseous ligament was under ension in volar abduction, opposition and flexion (positions F, K, J). A complex behavior was observed, best described by two portions, medial and lateral.

Discussion: This preliminary study on a model system depended on the interpretation of the ligament and joint surface anatomy. The method of creating joint motion described by Pieron enables comparison between two studies but does not correspond to the physiological position.

Conclusion: For a small-sized joint, magnification of the bony pieces and use of optical magnification facilitates apprehension of ligament lengthening during joint motion. This method can be used to better assess maximal range of motion according to ligament deformations observed in relation to joint solicitation.


Patrick BOYER Denis HUTEN Jean-Yves ALNOT

Purpose of the study: Fragile bone and weak soft tissues can create a serious challenge for arthroplasty of the rheumatoid arthritis shoulder. Patients seen late after rotator cuff tears become irreparable may also present a stiff shoulder, further complicating the procedure.

Material and methods: The purpose of this study was to assess outcome at more than five years in a prospective series of 12 patients with rheumatoid arthritis of the shoulder with an irreparable rotator cuff tear treated with a hemiarthroplasty with a mobile cup. The radiological and clinical results were compared with those obtained in a control series of ten bipolar humeral prostheses implanted for centered or excentered degenerative disease with irreparable cuff tears.

Results: The mean preoperative Constant score was 16.9 points: pain 2.5, activity 4.2, active mobility 9.5, strength 0.7. Active ROM was 63.8° for anterior elevation, 45° for abduction, and 12° for external rotation. At last follow-up, the mean postoperative Constant score was 39.4 points: pain 10.7, activity 10.8, active mobility 13.8, strength 4.1. Mean active anterior elevation was 83.7°, abduction 70.4°, and external rotation 29.1°. Outcome was not significantly different from the control group with degenerative joint disease (p< 0.05).

Discussion: The overall Constant score, especially the pain score, was significantly improved (p< 0.05). Improvement in joint motion was modest but comparable with other series in the literature and even better than with conventional hemiarthroplasty for the same indication. There were few complications, mainly superior subluxation favored by the preoperative infra-scapularis or infraspinatus tears. Glenoid wear was significant despite the dual mobility concept. There were no cases of loosening.

Conclusion: These results show that hemiarthroplasty with a mobile cut provides acceptable mid-term results for the advanced-stage rheumatoid shoulder with an irreparable rotator cuff tear. Results in this series were comparable with that in the control group of patients with degenerative joint disease. Consequently, the status of the rotator cuff appears to be more important that the inflammatory or degenerative etiology. Certain cuff tears involving the infrascapularis raise the risk of superoanterior instability and could be a limitation for this method. A more constrained prosthesis might be advisable.


Olivier VERBORGT Rami EL-ABIAD Dominique-François GAZIELLY

Purpose of the study: The purpose of this retrospective analysis was to assess long-term clinical and radiological outcome of humeral stems inserted without cement for shoulder arthroplasty.

Material and methods: The series included 37 shoulder arthroplasties (11 simple humerus prostheses and 26 total shoulder arthroplasties) performed between 1985 and 1998. Press-fit humeral stems were used for these patients with primary and posttraumatic shoulder degeneration and osteonecrosis. There were 13 Neer II (3M) prostheses and 24 Modular Shoulder prostheses (3M) which were designed for implantation with cement. Mean follow-up was 9.2 years (range 5.8–13.6 years). This series included 22 women and 15 men, mean age 57.7 years (range 33–82). The Constant score and the Neer classification were noted. Lucent lines, endosoteal erosion, and stem migration or tilt were noted on plain x-rays. A stem was considered ‘at risk’ of loosening in the presence of tilt or migration or lucent lines measuring > 2 mm in > 3 zones.

Results: At last follow-up, the mean non-weighted Constant score was 57/100 (16/95) and according to Neer, outcome was satisfactory in 70%. There was no complication and no revision related to the cementless stem was needed. The radiographic analysis failed to identify any stem migration. Lucent lines were observed for 22 components (59%), endosteal erosion for 12 (32%) and tilt for 5 (14%). Seven stems were considered at risk (19%). The prevalence of at risk stems was not correlated with patient-related or disease-related features, nor to the type of prosthesis, the length of follow-up or clinical outcome in terms of pain, Constant score or Neer classification.

Discussion: Neer initially designed a humeral component to be inserted with cement. This technique provided a humeral fixation which was very reliable, with very few loosenings reported. It was nevertheless very difficult to remove the cemented stem. For this reason, certain surgeons continued to use these stems designed for cemented implantation in a press-fit manner for simple humeral prostheses and for total shoulder arthroplasty.

Conclusion: This study demonstrated the favorable results obtained using these press-fit stems for shoulder arthroplasty. The rate of clinical looseninf was low at long-term follow-up.


Olivier VERBORGT Rami EL-ABIAD Dominique-François GAZIELLY

Purpose of the study: The purpose of this study was to compare mid-term results after total shoulder arthroplasty (TSA) versus simple humeral arthroplasty (SHA) for the treatment of primary centered osteoarthritic degeneration of the shoulder joint.

Material and methods: The series included 41 Aequalis prostheses (27 TSA, 14 SHA) implanted by the same surgeon. TSA was performed in 21 women and six men, mean age 68.3 years (range 51–78). SHA was performed in nine women and five men, mean age 68.3 years (range 58–83). The glenoid cavity presented concentric wear (type A) in 70% and asymmetric wear (type B) in 30% of patients undergoing TSA. Type A wear was observed in 57% of the patients undergoing SHA and type B (or C) wear in 43% of them. Mean follow-up was 35 months (range 24–49) for TSA and 37 months (24–59) for SHA. The Constant score and the Neer classification were noted. The position of the implants and lucent lines was noted on plain x-rays.

Results: For the TSA patients, the mean non-weighted Constant score was 82/100 points (gain of 48 points), anterior elevation was 151° (gain 54°), and active external rotation 44° (gain 29°). For the SHA patients, the mean non-weighted Constant score was 71/100 points (gain 41 points), active anterior elevation 135° (ain 46°), and active external rotation 43° (gain 28°). The Neer classification demonstrated excellent or satisfactory outcome for 93% of the TSA patients and 86% of the SHA patients. TSA was more effective than SHA for pain relief (p=0.045). Periglenoid lucent lines were observed for 63% of the TSA but with no loosening or complication for the glenoid component at last follow-up.

Discussion: Compared with a simple humeral prosthesis, total shoulder arthroplasty was more effective for the treatment of primary centered osteoarthritis of the shoulder joint.


David BENZAQUEN Pierre MANSAT Michel MANSAT Yves BELLUMORE Michel RONGIÈRES Paul BONNEVIALLE

Purpose of the study: Glenohumeral dysplasia is an uncommon cause of degenerative disease of the shoulder joint. In this context, arthroplasty is a therapeutic challenge due to the bony deformations.

Material and methods: Between 1998 and 2004, simple humeral prostheses were implanted in eight shoulders (seven patients, two men and five women, mean age 49.5 years). There was no procedure on the glenoid cavity. A Neer II was used for four shoulders (two dysplasic cases with short 63 mm stems) and a Neer III for four shoulders.

Results: At mean follow-up of 4.5 years (maximum 7 yers) the Neer outcome was satisfactory for five patients and non-satisfactory for two. Five of the seven patients were satisfied with their operation. The Constant scores improved: from 3.5 to 11.8 for pain, 9.8 to 16.6 for activity, and 13.8 to 24.4 for active mobility. Active anterior elevation was 114° on average, external rotation 25°, and internal rotation at level L3. The overall constant score was 52.8 points with a weighted score of 43%. Radiographically, there were no lucent lines around the humeral implant. Anterior dislocation occurred in one shoulder six months after the initial operation. Capsuloligament revision was performed but the implant was left in place. For one other shoulder, secondary rotator cuff tears limited the function outcome, but the prosthesis was not revised.

Discussion and conclusion: The results were average, but did allow our patients to resume nearly normal activity without pain. Looking at the failures in this small series suggests that the status of the rotator cuff is the main prognostic factor. Neither glenoid deformation nor the lack of replacement appeared to have an effect on the final outcome. Deformation of the proximal end of the humerus may require use of a shorter stem which should be available at the time of the operation.


Philippe CLAVERT Peter MILLETT Jon WARNER Jean-François KEMPF

Purpose of the study: Posterior glenoid erosio is a common finging in patients with degenerative joint disease of the shoulder. Anterior release is usually recommended, almost always with correction of the glenoid retroversion. There is no real consensus on the gravity of these posterior lesions nor on the appropriate attitude. The purpose of this study was to define the limitations of asymmetrical reaming during correction of excessive glenoid retroversion during total shoulder arthroplasty.

Material and methods: Five fresh cadaver shoulders were used. The size of the glenoid cavity and the humeral head were measured to select the optimal size for the glenoid implant. The scapula was embedded in resin. Posterior glenoid erosion was created by reaming to simulate wear producing retroversion greater than 15°. A control computed tomography (CT) was obtained to verify the lesion. The glenoid cavity was then prepared in the same manner as for prosthesis implantation, restoring neutral version to enable implantation of the prosthetic component of the size initially determined. A second CT was obtained to confirm the correction of the retroversion.

Results: The retroversion was corrected in all cases. At least one point of the implant penetrated the glenoid wall in all cases. In three cases, four points were outside the wall. In one case, reaming caused a fracture of the anterior glenoid rim. Finally, in one case, the size of the implant had to be reduced to avoid an oversized implant.

Discussion: The limitations for asymmetrical reaming to correct for posterior wear yet leave enough bone stock for implantation of a glenoid prosthesis are not defined. This study shows that asymmetrical reaming of the anterior rim of the glenoid cavity cannot satisfactorily correct for glenoid retroverson greater than 15° because of the frailness of the anterior wall and the risk the points will penetrate the rim. These complications compromise the primary stablity of the prosthesis and probably secondary short-term and mid-term stability.

Conclusion: If the glenoid retroversion is excessive (> 15°), it would be advisable to graft the posterior defect.


Philippe VALENTI Lieven DE WIELDE Denis KATZ Philippe SAUZIÈRES

Purpose of the study: The aim of this biomechanical study was to assess the performance of the deltoid muscle in the absence of a rotator cuff using different models for shoulder prosthesis.

Material and methods: A computer model reproducing the three dimensions of the glenohumeral joint was use to analyze the force of the deltoid muscle during abduction movements in shoulders devoid of a rotator cuff. The three heads of the deltoid were analyzed in order to determine the most effective level of muscle tension. The lever arm of the deltoid was measured from 0–90° abduction. Using this 3D model, we simulated implantation of six different models of reversed prostheses in order to assess the biomechanical situation which would be the most favorable for the deltoid. Performance of the normal deltoid was compared with the performance of the deltoid after implantation of an anatomic prosthesis and after implantation of an reversed prosthesis. Several variables were studied: medial offset of the center of rotation, lateral offset of the humerus, lengthening of the deltoid muscle.

Results: Optimal deltoid performance (especially from 60–90° abduction) was observed if the center of rotation was offset medially and the humerus was offset laterally and lowered. A 10% increase in the length of the muscle fibres increased muscle performance 18%. Exaggerated lateral offest of the humerus increased deltoid performance between 30 and 60° abduction but lost its beneficial effect at 90° abduction. From 15° abduction, a scapular notch appeared when the humerus was off set medially. This could be avoided if the humerus was offset laterally with a less medial center of rotation. Beyond 150° abduction, superior impingement appeared irrespective of the type of prosthesis.

Discussion and conclusion: This biomechanical study proved the superiority of reversed prostheses compared with anatomic prostheses for massive rotator cuff tears. Medial offset of the center of rotation reduced shear forces on the glenoid. Lateral offset of the humerus increase via a pulley effect the lowering force of the deltoid. Lowering the humerus pulled on the muscle fibers of the deltoid and increased their performance. Dosing these three variables with an appropriate («ideal») design for the reversed prosthesis would optimize deltoid performance in patients with deficient rotator cuffs.


Marc JUVENSPAN Geoffroy NOURISSAT Christian DUMONTIER Alain SAUTET

Purpose of the study: Treatment of irrepable massive rotator cuff tears remains a controversial issue. The purpose of this study was to assess clinical and radiological outcome in patients with a reversed shoulder prosthesis used for the treatment of irreparable massive rotator cuff tears with or without associated glenohumeral osteoarthritic degeneration.

Material and methods: Between 1996 and 2002, 55 reversed shoulder prostheses were implanted via a superolateral approach. Mean follow-up of the 15 men and 40 women (mean age 73 years, age range 57–86 years) was 34.8 months (range 24–84 months). The supraspinatus and infraspinatus tendons were retracted to the glenoid and ruptured in 100% of the patients: 27 shoulders (49%) also presented a infrascapularis tear. Glenohumeral osteoarthritis (Fukuda IV and V) was persent in 29 patients. Postoperatively, patients were assessed with the Constant score and radiographically on plain x-rays.

Results: Three patients were excluded from the analysis because of implant infection and removal before review. Subjectively, 90% of patients were satisfied or very satisfied. All items of the Constant score improved significantly (p< 0.0001). Active elevation improved from 65° to 123°. External rotation was not improved. Radiographically, there wre 41 shoulders with a grade 0, 1 or 2 notch (Nerot system), and 11 with a grade 3 or 4 notch. Thirteen patients (25%) presented heterotopic ossifications.

Discussion and conclusion: In this context, the clinical results obtained with this prosthesis are much better than with any other type of arthroplasty. Radiographically, heterotopic ossifications have a significant impact on the Constant score (p=0.015). Presence of ta glenoid notch is signifiantly associated with use of a medialized or retaining polyethylene cup (p< 0.0001). For us, loosening of the metaglenoidglenosphere bloc is related to the progression of the glenoid notch. For these reasons, it would be preferable to reserve this type of arthroplasty for patients aged over 70 years presenting an irreparable massive cuff tear with satisfactory glenoid bone stock sufficient for obtaining a good anchor for the metaglen. We recommend only using lateralized polyethylene cups.


Stéphane MENAGER Carlos MAYNOU Grégoire DAUPLAT

Purpose of the study: Infection is a rare complication of shoulder arthroplasty (0–4% according to Cofield). Many therapeutic options are available. Here we evaluated the midterm results obtained after arthroplastic resection used for the treatment of acute or subacute infections.

Material and methods: This series included nine patients (five females and four males) treated by arthroplastic resection. The dominant side was involved in five patients. Mean age at implantation was 63.5 years. The cause was a traumatic event in six cases, the others involving centered osteoarthritic degeneration, with one excentered case and one radiation-induced necrosis. Mean age at removal was 66 years. Mean duration of implantation was 2.39 years. The infection was subacute (two months to one year) in one patient and chronic (longer than one year) in eight. Implants were: cemented seven Aequalis prostheses (four for trauma, two with humerus prosthesis only, one total arthroplasty), one Depuy delta III reversed prosthesis, and one long Neer stem. The mean Constant score was 57.166 and the subjective outcome was considered good in six shoulders, fair in one, and poor in two before the infection-related degradation. Outcome of treatment was assessed clinically (Constant score and subjective assessment), and radiographically. Blood cell counts, erthrocyte sedimentation rate, and C-reactive protein levels were noted preoperatively and at last follow-up. The bacteriological results were available in all cases. Treatment consisted in arthroplastic resection in all nine shoulders, one using a spacer. Mean duration of postoperative antibiotic therapy was four months.

Results: A staphylococcal infection was identified in eight of the nine patients. Intraoperative complications were noted in 20%. Bacteriological cure was achieved in all patients at mean follow-up of four years, but with a significant functional impact (mean Constant score 28 points). Pain relief was satisfactory or very satisfactory in 100%. The subjective outcome was noted fair or poor in eight of the nine patients.

Discussion: Our results are compared with the data in the literature from the two main international series (Cofield, Boileau).

Conclusion: Our technique enabled bacteriological cure in 100% of patients who were all pain free, but at the cost of lost function.


Henry COUDANE Blaise MICHEL Frédéric ELOY Saïd SLIMANI Alain BLUM Jean-Pierre DELAGOUTTE

Purpose of the study: The objective was to analyse shoulder motion, particularly abduction and anterior elevation, in patients with an reversed prosthesis. A radiocinematographic study enable an analysis of the movements of the prosthesis it self and movements due to scapulothoracic participation.

Material and methods: This study was based on the analysis of 33 patients with an reversed shoulder prosthesis. A videoscopic recording (25 images per second) of anterior elevation from a workstation used for abduction arteriography was used. The Constant score was noted and a standard x-ray work-up (four views) was obtained for all patients.

Results: The cohort was a homogeneous continuous series of 21 women and 12 men, mean age 72.5 years (range 39–84). Two modes of motion were observed. The first (group 12, n=17 shoulders) was «monoarticular»: shoulder motion was almost exclusively related to movement of the scapulothoracic junction. Abduction did not exceed 90°. The second mode (group 2, n=16 shoulders) was «bi-articular»: joint motion began with the prosthesis (50° on average) followed by scapulothoracic participation (50° on average). The implant then was involved in the final part of the motion (in six of the 16 shoulders in group 2) to complete the range of motion exceeding 120° abduction and anterior elevation.

Discussion: This study confirmed the presence of an initial intrinsic mobility of the prosthesis followed by scapulothoracic participation. It was noted however, that for the majority of cases, the intrinsic mobility of the prosthesis was limited. In all cases, the range of motion recorded by clinical examination was greater than the range of motion measured objectively by radiocinematography.

Discussion: This study demonstrated the in vivo mobility of the reversed prosthesis. However, a range of motion greater than 100° anterior elevation and abduction is exceptional. Clinical findings reflect imperfectly the real mobility of this type of prosthesis.


Franck JOUVE Gilles WALCH Bryan WALL Laurent NOVÉ-JOSSERAND Jean-Pierre LIOTARD

Purpose of the study: Revision shoulder arthroplasty is generally considered to be a difficult procedure yielding modest improvement.

Material and methods: We report a prospective study of 45 patients, aged 69.8 years (range 49–85 years). Thirty-two patients had a simple humeral prosthesis and thirteen a total prosthesis. A reversed prosthesis was used for all revisions. The reasons for the revisions were classified into five groups: failure of prosthesis implanted for fracture (36%), glenoid problems of a total shoulder arthroplasty (24%), prosthetic instability (18%), failure of a hemiarthroplasty implanted for rotator cuff tear (11%), failure of a hemiarhtroplasty implanted for post-traumatic osteoarthritis (11%). The revision consisted in replacement with a reversed prosthesis. Patients were assessed pre and postoperatively using the Constant score for the clinical assessment and plain x-rays for the radiological assessment.

Results: Forty-one patients were reviewed at mean follow-up of 42.1 months (range 24–92). The four other patients died during the first two postoperative years. Subjectively, 73% of patients were satisfied. The Constant score improved from 187.7 to 55.6 on average. The best gain was obtained for the pain and daily activities scores.

Discussion: Revision shoulder arthroplasty provides only moderate improvement. Neer called a limited goal surgery. Results published on revision shoulder arthroplasty using a non-constrained prosthesis show that the functional gain is moderate. Revisio with a reversed total prosthesis gives better results because of the lesser impact of the cuff deficiency. The rate of complications after revision is greater than with first intention implantations.

Conclusion: Use of a reversed total shoulder prosthesis for revision shoulder arthroplasty provides encouraging results in terms of the mid-term functional outcome.


Philippe HERNIGOU Alexandre POIGNARD Olivier MANICOM Gilles MATHIEU Paulo FILIPPINI Ali DE MOURA

Purpose of the study: The humeral head is the second most frequent localization of non-traumatic osteonecrosis. For certain etiologies, for example sickle-cell anemia, the frequency is similar to that observed for the femoral head. There have nevertheless been very few publications on this pathology and its treatment. The purpose of this study was to assess outcome in a series of 771 cases of humeral head osteonecrosis in order to establish the natural history of the disease, criteria predictive of outcome, and therapeutic options.

Material and methods: The diagnosis of osteonecrosis of the humeral head was established for 771 humeri in 424 patients between 1981 to 2000. Minimum follow-up was five years (maximum 23 and mean 13 years). Outcome was assessed in terms of the clinical course, specifically the need for surgery due to pain or functional impotency. The radiological assessment was made on serial AP and lateral views taken every year or two years. The extent of the osteonecrosis was assessed on the basis of the magnetic resonance imaging (MRI) findings when available (after 1985). The ARlet and Ficat classification established for the femoral head was adapted to the shoulder: grade I: osteonecrosis of the humeral head visualized solely with MRI; grade II: radiologically detectable osteonecrosis; grade III: subchondral dissection without loss of spherical shape: grade IV: loss of spherical shape without visible osteoarthritis: grade V: osteoarthritis.

Results: Bilateral osteonecrosis was observed in 82% of the 424 patients. This gave 771 cases of humeral head necrosis. There was no gender predominance. Mean age at diagnosis was 32 years (range 18–57 years). The most frequent etiology was sickle-cell anemia (307 patients), followed by corticosteroid therapy (80 patients). Other etiologies were much less frequent: alcohol abuse, Gaucher’s disease, hyperlipidemia. Osteonecrosis of the humeral head was generally associated with another localization, particularly involving the hip and the knee joints. Multifocal osteonecrosis was also a common finding. Among the patients whose dignosis of osteonecrosis was established before symptom onset (scintigraphy or MRI performed in patients with multifocal osteonecrosis), the natural history was on average three years between MRI diagnosis and onset of pain. For 46% of the cases, pain appeared at grade I, before the development of radiographic signs. In 54% of the cases, grade II occurred before pain. It took six years before all of the cases with osteonecrosis diagnosed in a non-symptomatic phase produced pain. Factors affecting the rapidity of the radiological course were: etiology, size of the necrotic focus, presence and rapidity of osteonecrosis in other localizations (hip and knee). The humeral head lost its spherical shape on average four to five years after the diagnosis of osteoarthritic degradation of the joint, at about seven to eight years of evolution. Among the 256 patients followed for more than ten years, 51% required surgery. These 131 operations were for: drilling with bone marrow grafting (grade I or II) (n=62), cimentoplasty after loss of spherical shape but before glenohumeral osteoarthritis (n=15), resection of sequestered necrosis after loss of spherical shape (n=12), shoulder arthroplasty (n=42).

Discussion and conclusion: This study demonstrated that the natural history of osteonecrosis of the humeral head has a poor long-term outcome. Shoulder arthroplasty is rarely required during the first decade of the disease. Other therapeutic alternatives can help avoid or retard the need for shoulder arthroplasty in these very young patients.


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Christophe TROJANI Jean-Claude SANÉ Jean-Sébastien COSTE Pascal BOILEAU

Purpose of the study: The hypothesis of this study was that age over 50 years is not a contraindication for hamstring reconstruction of the anterior cruciate ligament (ACL).

Material and methods: Study period: September 1998 to September 2003. Type of study: prospective, consecutive series. The patient included in this study met the following criteria: age over 50 years at surgery; chronic anterior laxity, alone or associated with meniscal injury; one or more episodes of instability; absence of preoperative medial femorotibial osteoarthritis; no prior history of ligament surgery on the same knee. The same technique was used for all patients: four-strand single fiber arthroscopic hamstring ligamentoplasty using a blind femoral tunnel drilled via an anteromedial arthroscopic portal. All grafts were fixed with resorbable screws in the femur and tibia. The same rehabilitation protocol was used for all patients. IKDC scores were recorded. Plain x-rays were obtained (single leg stance ap and lateral views) as well as 30° patellar and passive Lachman (Telos).

Results: Eighteen patients were included, 12 women, mean age 59.5 years (range 51–66 years. Mean follow-up was 35 months (range 12–59 months). There were no cases of recurrent ACL tears, no loss of extension. Three patients complained of hpoesthesia involving the internal saphenous nerve and two patients presented postoperative knee pain. At last follow-up, the overall IKDC score was 7A, and 11B. All patients considered they had a normal or nearly normal knee. All were satisfied or very satisfied. None of the patients presented instability. The Lachman-Trillat test was hard stop in 13 cases and late hard stop in 5. The pivot test was negative in 16 knees and questionable in two. Mean residual differential laxity was 3.3 mm (range −1 mm to +7 mm) in passive Lachman. There was no evidence of osteoarthritic progression on the x-rays.

Discussion and conclusion: This series demonstrated that age over 50 years is not a contraindication for arthroscopic hamstring ACL grafting. This operation can be used to restore knee stability.


Cynthia HAMOU Didier HANNOUCHE Agnès RAOULD Rémy NIZARD Laurent SEDEL

Purpose of the study: Complex fracture-dislocation of the elbow, and subsequent surgical treatment, is often the source of a stiff joint. The purpose of this study was to assess the efficacy of a therapeutic protocol combining systematic insertion of a dynamic external fixator allowing early mobilization of the elbow with restitution of the radial height and the coronoid process.

Material and methods: This consecutive series of ten patient, six men and four women, mean age 49 years, age range 27–67 years, underwent surgery from 2002 to 2004. Three patients presented a posterior Monteggia fracture (two type IIA, one type IId associated with comminutive fracture of the trochlea), four patients presented a dislocation associated with a Masson 4 fracture of the radial head and two presented inveterated dislocations diagnosed three weeks after the traumatic event. In all, seven patients presented a fracture of the radial head and six a fracture of the coronoid process. For all patients, the operation consisted in stabilization with a dynamic external fixator of the elbow associated or not with restoration of the radial height with a radial head prosthesis (n=4) and reconstitution of the coronoid process (n=6). The lateral ligaments had to be reinserted in four elbows. The comminutive fracture of the rochlea was treated with an iliac crest graft.

Results: One patient died early. One patient presented pin tract infection and four developed heterotopic ossifications. At mean follow-up of twelve months, outcome was excellent in our patients, good in four, fair in one (Mayo clinic classification). All patients had a stable elbow. The mean range of motion was 89° flexion-extension and 145° pronationsupination.

Conclusion: In this series, systematic use of external fixation for complex fracture-dislocation of the elbow joint yielded satisfactory results when the element stabilizing the joint were appropriately restored and when rehabilitation was undertaken early.


Arnaud JARRY Gilles BURDIN Bertrand GALAUD Christophe HULET Bruno LOCKER Claude VIELPEAU

Purpose of the study: The purpose of this retrospective study was to analyze outome at more than one year of 33 anterior cruciate ligament (ACL) ligmanetoplasties performed in subjects aged over 50 years.

Material and methods: Between 1997 and 2002, arthroscopic ACL ligmantoplasty with a free graft was performed for 33 patients aged 50–67 years (mean 55.2 years). All patients were reviewed clinically and radiologically at least one year after surgery (mean follow-up 31 months, range 12–60 months). IKDC criteria and manual KT-1000 measurements were recorded. All subjects were classified C or D before the operation (IKCD 93 criteria). Plain x-rays were considered normal for 21 patients (63.5%) and eight (24%) presented remodeling of the medial femorotibial compartment or the intercondylar eminences. Four knees (12.5%) presented an asymptomatic narrowing of the medial femorotibial space (< 50%). In all patients, the indication for surgery was instability for daily life and/or sports activities, even for patients presenting an asymptomatic narrowing. An inter-articular patellar tendon graft, using two independent tunnels was performed for 29 patients. A hamstring plasty was performed for the others. Mean time from injury to surgery was 18 months. There were 15 lesions of the medial meniscus (45.5%). Six lesions were not repaired because they were considered stable. The lateral meniscus was involved less often (n=11 lesions). The lateral meniscal stock was preserved in nine knees. The rehabilitation protocol was the same as used for ligamentoplasty in young sportive patients.

Results: There were no intraoperative complications. Supplementary fixation of the tibia was required for three knees. All patients resumed their sports activities at the same level. The overall IKDS score was A for eight patients, B for 19 and C for six. For the patients in class C, the poor IKDC score resulted from persistent pain, generally present before the operation. Joint motion was preserved in 30 patients. IKDC laxity was A or B in all patients. At last follow-up, there was no radiological worsening and no meniscal injury left unrepaired required secondary treatment.

Conclusion: The operative technique was joint instability for daily life activities. Stability was improved in all patients, but the surgery did not improve pain relief. Age greater than 50 years is not a contraindication for arthroscopic reconstruction of the central pivot for chronic anterior instability. Fixation of the implant must be precise. The indication for surgery depends on the severity of the instability for daily life activities in a motivated patient.


Benoit GIRAUD Jean-Luc BESSE Jean-Luc LERAT Bernard MOYEN

Purpose of the study: Reconstruction of the anterior cruciate ligament (ACL) has become a common procedure. We compared two randomized series: intra-articular (Kenneth-Jones) versus intra- and extra-articular (MacInJones).

Material and methods: From January 1995 through March 1998, 73 knees were treated surgically for differential medial laxity measured at 7 to 12 mm on passive stress x-rays in 20° flexion. Group 1 (ACL reconstruction alone) included 34 patients (aged 27.1±7.5 years). Group 2 (ACL reconstruction plus extra-articular plasty) included 29 patients (aged 28.5±12 years). Function was scored 72% in group 1 and 68% in group 2 at mean seven years follow-up (102 and 93 months follow-up respectively). Anterior laxity was measured radiographically and with KT-1000 and the position of the tunnels was assessed according to Aglietti.

Results: According to the IKDC, functional outcome was 83.9±3.1 in group 1 and 83.3±3.6 in group 2. The overall IKDC classification was 0A, 57.8% B, 26.3% C, and 15.7% D for group 1 and 58% A, 52.9% B, 29.4% C, and 11.7% D for group 2. The pivot-shift test was negative in 61.1% of group 1 knees (27.7% grade 1 and 11.1% grade 2) and negative in 83.3% of group 2 knees (16.6% grade 1). In group 1, the radiological drawer showed 46.09% improvement in the differential laxity for the medial compartment and 41% for lateral compartment. In group 2 the corresponding improvements were 44.8% and 44.6%. There was no difference in tunnel position between the two groups.

Discussion: The two-year results of this series did not provide any evidence favoring a clear advantage of complementary lateral plasty. At seven years follow-up, the pivot-shift test appeared to favor associated lateral plasty (p=0.09), but with no significant difference in laxity for the two compartments.

Conclusion: Anterior laxity was only incompletely controlled by both reconstruction techniques. In this context of relatively limited laxity (7–12 mm initially), at seven years follow-up there was no certain advantage of complementary lateral extra-articular plasty in combination with ACL reconstruction.


Guillermo ARCE Pablo LACROZE Juan PREVIGLIANO Eduardo COSTANZA Matias CAÑETE

Purpose of the study: The debate continues on the appropriate tendon to use for anterior cruciate ligament (ACL) reconstruction. There are few comparative data on the different types of grafting material. We propose a retrospective analysis of bilateral ACL reconstruction where a patellar tendon (PT) and hamstring tendons were used in the same patient.

Material and methods: This was a phase IV trial. From December 1992 through March 2003, ACL reconstructions of both knees were performed in 46 consecutive patients using the PT for one side and hamstring grafts for the other. Follow-up was at least two years for 38 patients. There was no difference between the knees prior to reconstruction. The postoperative protocol was the same for both knees. The Lysholm Knee Score and the IKDC scores as well as KT1000 arthrometry were recorded.

Results: There was no difference between the two sides for laxity (KT1000) or resumed sports activity. Postoperative pain, loss of extension, joint stiffness, and anterior pain were greater on the PT reconstruction side. All patients except two preferred the hamstring reconstruction.

Conclusion: The results of this study show that the two types of reconstruction are equivalent in terms of objective outcome but that the subjective assessment favors hamstring reconstruction.


Guillermo ARCE Pablo LACROZE Juan PREVIGLIANO Eduardo COSTANZA Matias CAÑETE

Purpose of the study: The isometric position of the femoral tunnel is a critical element for successful anterior cruciate ligament (ACL) repair. An overly wide tunnel can compromise long-term results, requiring revision. The purpose of this prospective study was to evaluate the incidence of femoral tunnel widening on two fixation systems and to determine its impact on clinical outcome.

Material and methods: This prospective study included 80 four-strand hamstring ACL reconstructions. In group A, the titanium cross pinning method was used for fixation (Arthrex, Transfix) 30 mm from the Blumensaat line. In group B, two bioabsorble crossed pins (Mitek, Rigid Fix) were used 13 mm from the «anatomic» fixation. The two groups were similar for age, gender, degenerative disease and type of tibial fixation. Radiographic findings were noted at postop, and 6, 12 and 24 months follow-up. The diameter of the femoral tunnel was measured on the ap and lateral views. The diameter of the tunnel was compared with the drilled diameter. Outcome was assessed with the IKDC score and KT1000 arthrometry.

Results: Two-year follow-up data was available for 66 patients (34 in group A and 32 in group B). Postoperatively, tunnel widening was not significant in either group. At six months, the diameter of the tunnel had increased 62% in group A and 49% in group B. At one year, tunnel diameter decreased 24% in group A and 21% in group B. No significant difference was noted at 24 months. At two years, the tunnel diameter was not correlated with clinical outcome.

Discussion and conclusion: Widening of the femoral fixation tunnel does not alter long-term outcome of ACL reconstructions. While no significant difference was observed for the fixation systems studied in the present analysis, radiographic widening appears to be less for fixations closer to the «anatomic» fixation.


Olivier DRAIN Camille THEVENIN-LEMOINE Christophe BOGGIONE Olivier CHARROIS Philippe BOISRENOULT Philippe BEAUFILS

Purpose of the study: Injury to the infrapatellar branches of the medial saphenous vein are incriminated in disorder of the anterior aspect of the knee after bone-tendon-bone ligamentoplasty procedures. We have demonstrated in an anatomic study the usefulness of a minimal two-way approach for harvesting the patellar transplant in order to preserve the nerve branches. The purpose of this clinical study was to evaluate the feasibility of this method and its impact on the sensitivity of the anterior aspect of the knee after ligamentoplasty in comparison with the usual harvesting technique.

Material and methods: This non-randomized prospective controlled contemporary study included 47 consecutive patients. The graft was harvested via two vertical incisions, one on the apex of the patella, the other on the eminence of the anterior tibial tuberosity. After harvesting the patellar splint, discision of the patellar tendon fibers was performed subcutaneously to the tibial tuberosity. Before removing the graft via the tibial incision with a forceps inserted via the inferior incision without injuring the peritendon. A tibial piece was then harvested. The ligamentoplasty was performed as usual using two anterolateral and anteromedial arthroscopic portals. The tibial tunnel was drilled first on the tibial tuberosity. These 47 knees were compared with 34 knees where the conventional approach was used (control group). We assess: harvesting time, width of the tendon transplant, quality of the graft, requirement to convert to conventional harvesting technique. Patients were reviewed at six weeks, three months and six months to assess anterior pain, dysesthesia, surface area of hypo or anesthesia and at six months kneeling problem.

Results: Conversion was not necessary for any of the knees. Mean harvesting time was 17 minutes (control group ten minutes). A good quality graft was obtained in all cases. Thirty-five patients were reviewed at six months. No sensorial disorders were noted in 18 patients. Sensorial disorders were noted in 17 patients (permanent hypoesthesia in the control group). None of the patients presented anesthesia. The mean surface area presenting a sensorial disorder was 13.6 cm2 at six weeks (37.8 cm2 in the control group) and 8.85 cm2 at six months (23.4 cm2 in the control group). Mean gain compared with the control group was 62%. There were two cases of anterior pain at six months and no case of dysesthesia. Sixteen patients could kneel normally (none in the control group); kneeling was not possible in one patient.

Discussion: The infrapatellar branches of the medial saphenous nerve are often injured when harvesting a bone-tendon-bone graft for ligamentoplasty. Anterior disorders would in part be correlated with the degree of sensorial impairment on the anterior aspect of the knee. The subcutaneous harvesting technique presented here with two minimal incisions appears to be an attractive alternative.

Conclusion: Our study confirmed the feasibility of this harvesting technique which significantly reduces the surface area of sensorial disorders and avoids most kneeling problems.


Christophe HULET Benoit LEBEL Gilles BURDIN Armelle RÉGEASSE Bertrand GALAUD Bruno LOCKER Claude VIELPEAU

Purpose of the study: The issue of which graft to choose for anterior cruciate ligament (ACL) reconstruction is still a matter of debate. An analysis of the literature reveals the difficulty encountered when performing comparative trials. It is also difficult to demonstrate significant differences with results obtained with an insufficient number of patients. We propose here a meta-analysis in order to combine the results obtained with different comparative studies.

Material and methods: The literature search (Medline 1990–2005) was based on the following selection criteria: ACL reconstruction, patellar tendon (PT), gracilis and semitendinous (four-strand hamstring) reconstruction and comparative prospective study. Studies were retained with: > 30 patients per group, minimum follow-up 24 months, IKDC score. Evaluation criteria retained were: anterior pain, resumed activity, IKDC score, differential laxity. The relative risk (RR) statistical method with 95% confidence interval (CI) was applied. Means were calculated and the chi-square and z-tests were applied.

Results: Thirteen studies satisfied our inclusion criteria. These studies had included more than 1300 transplants. Mean rate of anterior pain was 23.2% with PR and 17.3% with hamstring reconstructions. The RR was 0.73 with a CI different from 1. The difference was significant. Resumption of sports activities at the same level, subjective assessment, number of failures, and overall IKDC score were not statistically different between the two types of transplants. The IKDC laxity score was not different but the residual maximal manual differential laxity was greater in the hamstring patients than in the patellar patients in 80% of the cases.

Conclusion: At the observed follow-up, free grafting with a four-strand hamstring tendon or a patellar tendon is an effective method for reconstruction of the ACL. Anterior pain is more frequent with the patellar tendon method and residual laxity is greater with the hamstring method. The long-term outcome will determine whether the residual laxity observed with the hamstring graft has a deleterious effect on the meniscocartilaginous structures. This criteria would minimize the advantage of this technique over the patellar tendon technique concerning the initial anterior pain.


Pascal CHRISTEL Mohamed Mohtadi EL KATEB Patrick DJIAN Guy BELLIER Sami BELHARETH

Purpose of the study: Failure of anterior cruciate ligament (ACL) ligamentoplasty is a major surgical challenge. Over the last decade, failures have been related to the use of synthetic material, but at the present time, most of the failures observed are related to an inappropriate position for the graft. The purpose of this work was to report a prospective cohort of 44 consecutive patients where the objective and subjective results of revision surgery were recorded.

Material and methods: Between January 2000 and January 2004, 44 patients with a healthy contralateral knee were included in this study: 26 males and 18 females, mean age 30 years (range 20–53 years). The majority of the initial grafts were patellar (57%), hamstring tendons had been used for 26%. The time from the first ligamentoplasty to revision reconstruction was 38.7±28.3 months. This was a first revision for 38 patients and six patients had had multiple revisions. The preoperative IKDC scores were: subjective 51.7±16.2; overall: 1B, 19C, 24D. The maximal manual differential laxity measured with KT1000 was 8.6±3.1 mm. In 70% of cases, the cause of failure was related to an inadapted position of the graft. At revision, grade 2 or 3 cartilage lesions were observed in 50% of knees. Reconstructions were performed with autografts: patellar tendon (39%), hamstring tendons (31%), or quadricipital tendon (29%), combined with lateral ligamentoplasty in 78% of the cases.

Results: Mean follow-up in this series was 14.7 months, minimum 12 months. At last follow-up, the IKDC scores were: 73.8±13.9 for the subjective assessment and 9A, 12B, 17C, 6D for the overall assessment. 67.7% of patients were satisfied or very satisfied. The maximal manual differential laxity measured with KT1000 was 4.3±3.5 mm. All variables exhibited statistically significant improvement. Grade B or C radiologial modifications were noted in 32% of cases.

Discussion and conclusion: Complete analysis of the clinical findings searching for combined laxity as well as a precise preoperative radiological work-up is the key to a successful operative strategy. Data provided by this series confirmed that outcome is less satisfactory after revision reconstruction of the ACL than first-intention ligamentoplasty. Most of the knees involved however present cartilaginous and meniscal lesions with associated peripheral injuries. Short-term cartilage degradation is a worrisome problem and emphasizes the importance of correctly positioning the ACL graft at the primary surgery.


Bertrand GALAUD Gilles BURDIN Mathieu MICHAUT Christophe HULET Bruno LOCKER Claude VIELPEAU

Purpose of the study: Free patellar tendon plasty is the most common technique for repairing anterior knee laxity. Functional outcome can be compromised by invalidating knee pain. The purpose of this prospective randomized study was to compare the outcome of plasty procedures using hamstring tendon versus patellar tendon autografts.

Material and methods: From May 1998 through May 2001, 100 patients presenting an isolated grade I anterior cruciate ligament (ACL) tear were included. Exclusion criteria were: history of fracture, advanced-stage laxity (grade II or greater), and contralateral ACL tear. Randomization was performed in the operative theater using the closed envelop method. Two groups of 50 patients were designated: group A: arthroscopic free bone-tendon-bone patellar autograft; group B: arthroscopic free four-strand hamstring autograft. Two metallic interference screws were used for fixation in both groups. The two groups were comparable for demographic features and clinical, radiological, and instrumental laxity variables recorded before surgery. The position of the tunnels was noted according to Aglietti and was the same in the two groups. The same rehabilitation protocol in a dedicated center was used for both groups. All patients (none lost to follow-up) were assess using the IKDC 1993 criteria with objective instrumental measurement of residual laxity. The level of significance was set at 5%.

Results: There was no significant difference between the groups regarding: resumption of sports activity (level and delay), joint motion, ligament examination, the overall IKDC score, and radiological findings ate mean 40±13 months (range 13–69 months) follow-up. Pain at the harvesting site was observed in 34.78% of patients in group A at six months and in 39.5% of those in group B. Conversely, anterior pain was found in 8.5% of patients in group B at six months and 6.6% at one year (p< 0.05). This statistically significant difference disappeared at two years. Instrumental differential laxity was 0.57±1.3 mm in group A and 1.22±1.9 mm in group B (p=0.56, but with power < 80%). There were two cases of repeated traumatic tears in each group. Repeated meniscectomy was performed in one patient in group A and in three in group B (p=0.3074).

Conclusion: The results at 40 months follow-up of this prospective randomized study with no patients lost to follow-up confirmed the minimal morbidity observed at the harvesting site for hamstring plasty. There was no significant difference between the transplants (patellar tendon, hamstring). Anterior pain with the patellar tendon plasty attenuated after two years. Residual laxity was greater when using the hamstring method.


Cyril DAUZAC Pascal GUILLON Didier GIHR Marc MAN Mansef BENSAIDA Rodolphe LEROUX Catherine MEUNIER Jean-Michel CARCOPINO

Purpose of the study: The objectives of this study were to measure tension force usually applied to the transplant and analyze its impact on postoperative laxity and joint mobility.

Material and methods: This was a prospective consecutive study. Inclusion criteria were: isolated tear of the anterior cruciate ligament (ACL) more than three months earlier, healthy contralateral knee, radiological anterior drawer measurements (Telos 20 kg) both pre and postoperatively, follow-up greater than six months. ACL reconstruction was achieved with a free bone-tendon-bone patellar transplant using the blind technique. A dynometer was used to measure the traction force applied by the operator using the «usual» method for the tibial fixation. The force applied (2, 4, 6, 9, or 11 kg) was recorded by the assistant and was maintained constant while screwing. Variables studied were: tension force applied to the transplant by four different operators, mobility of the two knees, differential laxity pre and postoperatively (L0 and L1) and relative gain in laxity (real gain/ideal gain).

Results: The study included 22 patients, mean age 26 years. Mean tension force applied was 7.68 kg and varied from 7.3 to 8.1 for each operator. Mean extension and flexion deficit compared with the healthy side was 1.6° and 3° respectively. There was no correlation between loss of mobility and tension applied. Mean laxities (L0 and L1) were 9.2 and 5.4 mm respectively. Mean minimal differential laxity (< 5 mm) was obtained for tension forces of 4 to 6 kg. There was no correlation between tension and L1. The relative gain was greater in the knees with tension at 6 kg. But there was no correlation between these two variables.

Discussion: This study provides the only available data on tension forces applied in routine practice. This tension does not appear to have an impact on the final joint mobility. It would appear however tht laxity would be minimal for tension forces to the order of 7 kg. These data are in agreement with reported in the literature were it is recommended to apply tension to the order of 1.5 to 7 kg.

Conclusion: It would not appear that measuring the force applied to the implant during the tibial fixation provides useful information for routine practice. The force applied in routine practice appears to give the best gain in stability without limiting joint mobility.


Sofiane BOULARES Michel VANCABEKE Philippe PUTZ Frédéric SCHUIND

Purpose of the study: The objective was to compare the results of ligamentoplasties with two commonly used grafts, hamstring and patellar tendon. This was a prospective randomized study.

Material and methods: Between January 2001 and June 2004, 98 patients with an acute or chronic anterior cruciate ligament (ACL) tear with joint instability were included in this randomized study for arthroscopic repair. Patients were randomized to the patellar or hamstring arm. Clinical assessment was based on laxity, IKDC score, Lyscholm score, pain visual analog scale (VAS), midthigh thickness and isokinetic assessment at three months. Measurements were recorded preoperatively and at 1, 3, 6 weeks and 3, 6, and 12 months.

Results: The two groups were comparable regarding gender, morphotype, associated lesions, and activity level. There was no difference in operative time or in recovery of complete extension. Anterior laxity was the same in the two groups. The isokinetic deficit appeared to be greater in the bone-tendon-bone group at three months. The IKDC and Lysholm scores were not significantly different at six and twelve months. Harvesting site morbidity was more pronounced in the bone-tendon-bone group.

Conclusion: The two techniques provide good results. The bone-tendon-bone technique appears to cause greater harvesting site morbidity. While the isokinetic results appear to be better in the hamstring group, the measurements of laxity and recovery of stability did not show any difference.


Fabrice DUPARC Dorothée COQUEREL Pierre-Yves MILLIEZ Isabelle AUQUIT-AUCKBUR Norman BIGA

Purpose of the study: Surgical reconstruction procedures using the gracilus myocutaneous flap may be compromised if partial or total necrosis of the skin cover develops. The purpose of this study was to describe the anatomic blood supply to the gracilus muscle and the corresponding skin cover in an attempt to better understand the arterial afferences to the skin and define the safest topography for a transferable zone of skin.

Material and methods: We dissected the thighs of human adult cadavers to detail the vascular bundles feeding the gracilus muscle.

Selective injections of methylene blue were used in the main gracilus pedicle; the area of skin colored was then measured (greatest and smallest diameter) for computation of the surface area using an imaging software.

Selective injection of a colored latex fluid enabled description of the perforating vessels between the muscle body and the skin cover.

Results: Preliminary results of nine dissections showed that the main blood supply of the gracilus muscle arose from the deep femoral artery (n=8 dissections) or the common femoral artery (n=1 dissection) then penetrated the muscle 90.55 mm below the pubis with a mean diameter of 1.32 mm. The muscle was fed by one to four accessory arteries. The skin cover was stained in all cases, the area involved lying over the proximal and mid thirds of the muscle. The surface area was irregular, the mean length being 127.5 mm and the mean width 91.66 mm. The computed surface area was 88.08 cm2 on average (range 58–120.95 cm2). Each muscle had two to six perforating vessels issuing from the opposite side of the main pedicle and comprised within a 48 mm long segment before dividing at the subcutaneous level. A mathematical model correlated the skin surface area to the number of perforating arteries.

Discussion and conclusion: Our findings suggest it would be possible to determine the surface area of skin transferable with a gracilus muscle flap based on high-frequency duplex-Doppler assessment of the number and position of the perforating arising from the muscle and feeding the skin surface. The linear distribution of the surfaces measured as a function of the number of perforating arteries suggests that more reliable conditions for gracilus myocutaneous flap harvesting could be proposed to minimize the risk of cutaneous necrosis.


Jérôme JEUDY Jérôme PERNIN Patrick CRONIER Philippe MASSIN

Purpose of the study: Locked plating is an attractive alternative to external fixation for the fixation of distal shaft fractures of the radius, particularly in cases with metaphyseal comminution. The purpose of this study was to assess prospectively outcome with locked anterior plate fixation in a series of 43 complex fractures of the distal radius treated between October 2003 and November 2004.

Material and methods: The AO LCP 3.5 plate (Synthes) was used. The series included 27 women and 15 men, mean age 55.5 years (range 17–83 years). We included fractures with major metaphyseal comminution according to the M.E.C classification established by Laulan (18 M2, 14 M3, and 9 M4). According to the AO classification, there were nine extra-articular fractures (eight A3 and one A2) and 35 articular fractures (ten B3, two C1, four C2, and seventeen C3). Posterior displacement was noted for 22 fractures. In eight cases plate fixation was a second intention procedure due to secondary displacement occurring on average eight days (range 3–21 days) after trauma for a fracture initially treated with infrafocal pinning. An epiphyseal locking screw was used in all cases. An antebrachiopalmar immobilization orthesis was worn for six weeks on average (range 3–9 weeks). The first-intention anterior plating was combined with an intrafocal posterior pin for 13 patients and with an external fixator in one. Radiographic outcome was reported in terms of joint congruency and using the SOFCOT symposium criteria for the 41 patients reviewed at bone healing.

Results: Anatomic restitution was achieved in 23 patients (55%). There were two purely intra-articular calluses due to failure of the primary reduction, both measured less than 2 mm. Fifteen moderate misalignements (36%) were noted, most (84.7%) involving moderate sagittal inclination, the distal radioulnar index being preserved. Two major misalignments (5%) were related to early disassembly of the osteosynthesis.

Conclusion: Locked anterior plating has provided promising results for maintaining radial length in distal radial fractures with major metaphyseal comminution. There remains a certain number of cases with a moderate and persistent posterior inclination and a few cases of defective intra-articular reduction.


Claude SERRA Antoine COUSIN Olivier DELATTRE

Purpose of the study: Unlike thoracic and abdominal stab wounds, little has been reported about blade wounds to the forearm. We report a serie of machete wounds to the forearm treated in the Caribbean island Martinique, between 1997 and 2004.

Material and methods: This study included 14 open fractures of the forearm caused by machete wounds. This retrospective analysis was based on the patient files. We studied the mechanism of the fracture, the type and level of the fractures, the associated lesions, the type of treatment given, and complications observed.

Results: Mean follow-up was seven months. Among the 14 patients studied, 14 presented an ulnar fracture, and five a radial fracture. Five patients suffered a complete amputation of the hand. Ten patients (71%) also had associated tendon injuries, all on the ulnar side. Three associated vascular injuries were noted (21%), two on the ulnar side. There were four nerve lesions (29%) involving the ulnar nerve alone (n=2),the ulnar and medial nerves (n=1) or all of the nerve trunks (n=1). The fractures involved the distal third of the forearm in nine patients (64%) and were comminutive for ten (71%). A complete fracture was noted in twelve patients (86%) with a partial fracture in two. Osteosynthesis was performed in all cases. There were nine complications: early infection (n=2, due to late referral), stiff joints (n=6, 43% including tendon retraction in five), nonunion (n=2, one repeated case) and one late healing at one year. Motor and sensorial sequelae were observed at last follow-up in all patients with an initial nervous lesion.

Discussion: The mean follow-up in our patients was short because of the specific context (homelessness, drug addiction). Most of our patients refused medical follow-up. The strong predominance of bony or soft tissue injuries observed on the ulnar side of the forearm corresponds to the mechanism of defense used by the victims. Despite the fact that the wounds were soiled and that the patients failed to comply with medical advice, the rate of early and secondary infection was low. Stiff joints due to tendon retractions and motor deficits were however frequent and compromised the functional outcome.

Conclusion: Fractures of the forearm by machete wounds generally occur in a typical situation of self defense. The characteristic injury to the ulnar side of the forearm results from this mechanism. Tendon and nervous complications are common and cause invalidating sequelae. Secondary infection is exceptional. Prolonged regular follow-up could probably improve the functional outcome of these particular injuries.


Luciano POITEVIN

Purpose of the study: Investigate the longitudinal stability and instability of the forearm.

Material and methods: The interosseous membranes of 30 formol-treated forearms were dissected under 4-fold magnification and translumination. The radial and ulnar heads wee resected to eliminate the two radioulnar articulations before performing sequential cuts to identify the different networks of the interosseous membrane. The ulna was maintained in a fixed position allowing proximal and distal displacement of the radius. We studied the medial border of 100 radii, noting the bony eminences and their relations with the configuration of the membrane.

Cases of neglected fractures of the radial cup without injury to the distal radioulnar joint and cases of polyarthritis treated by double resection radioulnar and Sauvé-Kapandji) presenting good longitudinal stability were studied.

The possiblity of using the extensor indicis for primary reinforcement of the interosseous membrane was studied on cadaver specimens. Applied to an acute case of Essex-Lopresti syndrome, this original technique provided good intraoperative stability.

Results: The fibers of the interosseous membrane design two planes, an anterior and a posterior plane. The anterior fibrrs descend distally and medially from the radius. They can be divided into proximal (horizontal) descending fibers, intermediary (short oblique) descending fibers, and distal (long oblique) descending fibers. The posterior fibers rise proximally and medially from the radius to reach the ulna. They form two planes: proximal ascending (short oblique) fibers and distal (long oblique) ascending fibers which are inconstant. These planes are in relation with the origin of the extrinsic wrist extensors.

The main fibers are: the intermediary descending fibers and the proximal ascending fibers. They insert on the interosseous tubercle of the radius, a constant eminence situated on the medial border of the radius 8.4 cm from the elbow.

The thre groups of descending fibers limit proximal translation of the radius. The proximal fibers can limit excessive distal translation. The proximal and distal ascending fibers limit distal translation of the radius. A full thicknes tear of the anterior plane is necessary to achieve proximal displacement. Longitudinal stability is maintained in neglected fractures of the distal without rupture of the interosseous membrane and in operated polyarthritis with resection of the two radioulnar joints.

Conclusion: The fibers of the interosseous membrane describe two planes where the fibers run in opposing directions. Each plane limits radial displacement in a different direction. The ideal reconstruction would restore the two planes, but it is essential to reconstruct at least the intermediary descending fibers and the proximal ascending fibers. However, in routine practice, translation of the radius is generally proximal, so reconstruction of the middle segment appears to be sufficient if it associated with a reinforcement transfer of the extensor indicis to the proximal radius.


Valérie ASSI Philippe LIVERNEAUX

Purpose of the study: The role of injectable phosphocalcium cements for the treatment of fractures of the osteoporotic distal radius is poorly defined. Simple adjunction of a phosphocalcium cement to infrafocl pinning has not proven its efficacy. To improve this percutaneous technique, the purpose of this work was to study the contribution of prior metaphysodiaphyseal preparation by drilling to increase the quantity of cement injected and to improve is distribution on either side of the fracture line, with the hope of limiting the progressive degradation of the radioulnar index.

Material and methods: Sixteen patients aged 76.5 years on average (range 65–92 years) were treated starting in 2004 for fractures of the distal radius with posterior displacement and very porotic bone. After orthopedic reduction with external manoeuvres, three n°18 pins were introduced into the fracture focus percutaneously. After pin insertion, a fourth stab incision was made at the apex of the radial styloid process for insertion of a n°11 trocar which was advanced to the medial cortex without perforating it. The trocar was then removed to allow insertion of a curved pin for the purpose of drilling out the remaining bony network to the distal part of the shaft through to the subchondral bone. 20 mg Cementek LV® was then injected under fluoroscopic control. The postoperative protocol was as usual with an orthesis for six weeks and pin removal at six weeks.

Results: Mean follow-up was nine months. There were five complications which resolved (reflex dystrophy). On average, 4.6 ml was injected. There were eight cases of cement leakage which was «milked out» as much as possible via the skin incision. Leaks resorbed in a few months and did not have any clinical impact. At follow-up, clinical outcome (pain, strength, mobility, DASH), and radiological indices were satisfactory. Loss of the distal radioulnar index was 1 mm on average.

Discussion: This technique for drilling, cementing, pinning, appears to limit secondary displacements of distal radial fractures with osteoporotic bone. Cement leakage is not sufficient to contraindicate this method since all observed leaks resorbed spontaneously with no sequelae. Longer follow-up will be necessary to confirm these encouraging results.


Jean-Michel COGNET Mathieu EHLINGER Caroline MARSAL Vanessa KADOSH Akim GEAHNA Stéphanie GOUZOU Patrick SIMON

Purpose of the study: Since 2001, we have used arthroscopy systematically to control the treatment of distal radius fractures. We report our three years experience.

Material and methods: Arthroscopic control was used for all patients aged less than 65 admitted to our unit for treatment of an articular fracture of the distal radius. The same operator performed all procedures. Fixation methods were: K-wire pinning, locked plating (Synthes) or a combination of these two methods. The arthro-scope had a 2.4 mm optic. Bony lesions were noted according to the Cataign, Fernandez and AO classifications. The DASH, Green and O’Brien, and PWRE scores were noted.

Results: Intraoperative arthroscopic control was performed for 61 patients between November 2001 and November 2004. Mean follow-up was 17 months (range 6–36 months). Arthroscopic exploration revealed: scapholunate ligament tears (n=11), lunotriquetral ligament injuries (n=3), pathological perforations of the triangle complex (n=4), damage to the radial cartilage (n=15), and mirror involvement of the carpal cartilage (n=4). An arthroscopic procedure was necessary to treat a bone or ligament lesion in 28 cases. At last follow-up, the DASH score was 19.3 and the PWRE 37.6.

Discussion: Arthroscopic evaluation of articular fractures of the distal radius, a routine practice in English-speaking countries, remains a limited practice in France. There is nevertheless a real advantage of using intraoperative arthroscopy. The particular anatomy of the radial surface makes it impossible to achieve proper assessment on the plain x-ray for a quality reduction of the fracture. Recent ligament injuries are rarely detectable on a wrist x-ray. An intra-articular stair-step or an untreated ligament injury can pave the way to short-term development of osteoarthritic degeneration. Intraoperative arthroscopic control is the only way to diagnosi and treat these osteoligamentary lesions observed in patients with an articular fracture of the distal radius. For us, non use of intraoperative arthroscopy constitutes a lost chance for patients with an articular fracture of the distal radius.


Hervé PICHON Abdel CHERGAOUI Stéphan JAGER Eric CARPENTIER Christophe CHAUSSARD François JOURDEL Dominique SARAGAGLIA

Purpose of the study: Treatment of distal fractures of the radius with posterior displacement remains a controversial issue. In the past, the anterior approach used for osteosynthesis failed to enable sustained reduction. With the recent development of locked plating systems, it might be useful to revisit this technique.

Material and methods: Between November 2001 and April 2003, 23 patients (15 females, 8 males), mean age 55 years (range 17–75 years) were treated with an LCP 3.5 T plate (Mathys Medical SA, Bettlach, Switzerland). The anterior Henry approach was used. There were 16 extra-articular fractrures and seven with an associated intra-articular fracture line. Radiographic analysis searched for secondary displacement and was coupled with clinical examination with force measurement (DASH). The Herzberg score used for the SOFCOT 1999 symposium was noted.

Results: Eighteen patients were reviewed with mean follow-up of 16 months. Radiologically, all fractures had healed at twelve months, with only one case of secondary loss of reduction. According to the SOFCOT symposium criteria, bone healing was anatomic for 13 cases and with moderate misalignment for five. Wrist force (Jamar) on the operated side was 95% of the opposite side. The mean DASH was 22.7. The Herzberg outcome was: excellent (n=9), good (n=6), fair (n=3), and poor (n=0). Complications were: reflex dystrophy (n=4), carpal tunnel syndrome (n=1), cheloid scar (n=1), irritation of the common extensor of the fingers (n=1).

Discussion: Secondary displacement after fracture of a posteriorly displaced fracture of the distal radius frequently lead to misalignment which is often poorly tolerated. The LCP system maintains a stable reduction long enough to reduce the rate of secondary displacement.

Conclusion: A comparative study of the commonly applied techniques (pinning) would be necessary to define the appropriate indications for this more costly technique.


Guillermo BRUCHMANN

Purpose of the study: Fractures of the distal radius have been underestimated by specialists. Several authors have reported serious functional sequelae resulting from incorrect treatment of these fractures. Treatment of these fractures has now been improved significantly thanks to correct interpretation of the pathogenic mechanisms and factors of instability and to the establishment of a correct classification enabling adequate surgical treatment.

Material and methods: Over the last five years (1994–2005) we have treated more than 600 fractures of the distal radius. Among these, we evaluated 480 treated at the Eva-Peron hospital and in our private clinic in Rosario. An original system of radio-radial external fixation was the only treatment to final bone healing. The system enables immediate mobilization of the articulation, favoring rapid rehabilitation and improving patient comfort. Taking into account the distinct factors of instability, basically five factors, we developed a simple classification system which accounts for not only the pathophysiology of these fractures but also indicates the appropriate treatment.

Results: Considering our series of 480fractures followed for 18 months, the Green and O’Brien system noted: among 180 patients with extra-articular fractures, excellent and good outcome in 171 (95%) and fair outcome in 8 (5%); among 300 patients with intra-articular fractures, excellent and good outcome in 279 (93%) and fair outcome in 21 (7%). Factors of stability were as classically noted:

comminution of the dorsal wall;

anterior wall damage deeper than 2 mm;

intra-osseous cavitation due to a crushed medullary canal. Two other instability factors were observed:

comminution of the medial wall of the radius;

free styloid process disconnected from the articular fragment. The classification system was as follows.

Fractures without dislocation. Fractures with dislocation 1) extra-articular: ligamentotaxy + pinning + cast or ligamentotaxy + pinning + radioradial fixator. 2 intra-articular.

Type I: without comminution of the medial wall, styloid process connected to the articular fragment: ligamentotaxy + pinning + cast or ligamentotaxy + pinning + radioradial fixator.

Type II: with comminution of the medial wall, «free» styloid process: open surgery (reduction and stabilization), bone grafts for osteodesis or osteosynthesis, plating + bone grafts (as needed) with a metacarpal radio-radial fixator.

Type III: complex comminutions, radioradial fixator, 2nd metacarpal (formal indication).

Discussion: We consider that if the instability factors are taken into account, these fractures can be classified correctly. This enables proper reduction ans adequate stabilization, usually without open surgery in the majority of patients. Outcome is highly satisfactory and open surgery can be used when unavoidable.


Jean-Michel COGNET Akim GEAHNA Caroline MARSAL Vanessa KADOSH Stéphanie GOUZOU Patrick SIMON

Purpose of the study: We report our experience with the LCP DRP 2.4 plate with a locking screw for the treatment of distal factures of the radius.

Material and methods: Between 2003 and June 2004, 67 displaced fractures of the distal radius were treated with a LCP DRP 2.4 system. Patients were subsequently immobilized in a removable anatomic orthesis for three weeks. The Fernandez, Castaign and AO classifications were used. Clinical evaluation was based on the DASH test, the Green and O’Brien score and the PWRE.

Results: Clinical assessment was available for 59 patients who also responded to the questionnaires. Mean follow-up was eight months. Healing was achieved in six weeks. There were no cases of secondary displacement nor of lost reduction. The mean Green and O’Brien assessment was 85% good and very good outcome, the mean DASH score was 20.6 and the mean PWRE was 32.8.

Discussion: Appropriate fixation for fractures of the distal radius remains a controversial issue, as illustrated by the variety of treatments used, the different materials proposed for fixation, and the large number of publications. The primary stability achieved with the locking screw in the LCP plate enables early rehabilitation. The absence of secondary displacement, irrespective of the quality of the bone, enables equivalent results in osteoporotic patients as in younger patients. No other material has enabled equivalent results to date. This is a major advance in osteosynthesis.


Rémy NIZARD Anne LACHERE Omid RADMANESH Didier HANNOUCHE Laurent SEDEL

Purpose of the study: Computer assisted surgery for total knee arthroplasty is widely used in Europe. The reliability of these systems appears to be very good with bone cuts within 3° of the planned mechanical axis. Nevertheless, the relationship between intraoperative measurements provided by the navigation system and the postoperative gonometry can be used to assess the quality of realignment. The purpose of this work was to determine this relationship.

Material and methods: Thirty-three knees operated on with the Navitrack® system were assessed. Two senior operaters performed all procedures. An Omnia® cemented prosthesis with an ultracongruent fixed plateau was used in all cases. Intraoperative measurements wer made with the definitive prosthesis after cement solidification without stress on the knee. Postoperative gonometry was undertaken when the intraoperative flexion had disappeared six weeks to six months after the operation. Gonometric measurements were made by an independent operator using a computerized system operating on digitalized x-rays. The gonometric protocol had been standardized previously and only the gonometric measurements in compliance with this protocol were retained for analysis. The difference between measurements was analyzed with the t test for paired variables. Search for correlations was also performed.

Results: On average the intraoperative deviation was 0.8±0.8° (3° valgus to 2.4° varus). The postoperative gonometry showed 1.7±1.1° (3.4° valgus to 4.3° varus). The mean difference between the intraoperative axis and the measured postoperative axis was significant (p< 0.0001). There was no significant correlation between intraoperative and postoperative measurements.

Discussion: Computer-assisted navigation systems have their limitations which should be measured. The present findings would demonstrate a significant difference of minimal amplitude between the intraoperative measurement and the postoperative gonometry. Although the clinical pertinence of this difference remains to be demonstrated, it must be kept in mind for safe use of these navigation systems.


Ludovic LINO Xavier FLECHER Jean-Manuel AUBANIAC Jean-Noël ARGENSON

Purpose of the study: Compter-assisted surgery enables improved precision of prosthetic implantations, but the basis of data acquisition remains variable. The purpose of this study was to assess the radiological quality of a total knee arthroplasty (TKA) implanted with a computer-assisted surgical technique with or without pre-operative imaging.

Material and methods: This was a case-control study of a group of 40 patients who underwent TKA implanted with a navigation systm (N+) which was compared with a control group of patients who underwent the same procedure with a conventional technique (N-). The two groups were comparable for: age, gender, BMI, preoperative HKA. The same surgeon operated all patients using the same cemented posterior stabilized TKA. Outcome was analyzed by an independent operator. The same navigation system was used for all knees, with, for the first 20 knees, acquisition based on preoperative computed tomography and for the next 20 knee, intra-operative acquisition. Postoperatively, six radiographic parameters were studied for each knee on the ap and lateral views. An optimal interval was determined for each parameter and the number of optimal criteria was noted for each knee.

Results: The mean HKA was 177.5° in the N- group and 179.2° in the N+ group. The angle of implantation of the femoral piece was 90.3° in the N- group and 90° in the n+ group. The mean posterior tibial slope was 3.5° in the N+ group and 3.1° in the N- group. There was a significant difference for the tibial prosthetic angle in favor of the N+ group, i.e. 89° compared with 87.3° for the N- group. The overall quality of the implantation was considered optimal for 54.5% of knees in the N+ group and for 29.8% in the N- group. There was no significant difference between computed tomographic acquisition and intraoperative acquisition.

Discussion and conclusion: This study demonstrates that the results exhibit a distribution closer to the ideal values for the navigation group but that the difference is solely significant for the tibial implantation. This improvement requires a longer operative time of 18 minutes. The lack of any difference between the computed tomographic acquisition and the intraoperative acquisition suggests that intraoperative acquisition should be favored for reasons of cost and simplicity. Computed tomography imaging can still be useful for a precision of the biepicondylar line in certain complex situations such as revision arthroplasty.


Christophe CHANTELOT Frédéric LECONTE Guillaume WAVREILLE Aristote HANS MOEVIS Guillaume PRODHOMME Christian FONTAINE

Purpose of the study: Appropriate management of chronic sprains of the scapholunate joint remains a subject of debate. Different surgical techniques have been proposed, from partial arthrodesis of the carpus to ligamentoplasty. We opted for scaphocapitatum arthrodesis. The purpose of this report was to assess clinical and radiological outcome.

Material and methods: From 1997 to 2001, 13 arthrodeses (13 patients) were performed for this indication. The procedure involved two screws (n=11), one screw and stapling (n=1), and stapling alone (n=1). A free autologous graft was used in all cases. Mean patient age was 40 years (12 males and one female). These patients were victims of sports accidents (n=8) or occupational accidents (n=5). Mean follow-up was 26 months (range 24–31 months). Variables noted were joint mobility, pain, grasp force and pinch force. Wrist x-rays were used to measure the height of the carpus and the radio-lunate angle.

Results: A 31% loss in the radial inclination was noted as as a 14.5% loss in the ulnar inclination. Dorsal flexion of the wrist declined from 60° to 48°, palmar flexion from 47° to 28°. Stiffness mainly involved the radial inclination and palmar flexion. Grasp and Pinch forces improved (125° on average). All patients excep one presented residual pain. Six patients complained of pain only for efforts and six presented invalidating pain. Only seven patients were able to resume their occupational activity. There were three cases of nonunion which required revision to achieve final bone healing (poor outcome). Carpal height improved (0.47±0.54). The mean radiolunate angle at last follow-up was 11°. DISI persisted in only one wrist.

Discussion: This technique reduced wrist mobility. For all patients, the dorsal approach to the wrist produced inevitable stiffness. Radial inclination declines due to the intracarpal fusion. This arthrodesis enabled restitution of the carpal height and partially corrected for the DISI. This operation did not provide pain relief but did not alter the carpal x-ray. We raise the question of the pertinence of associating this type of arthrodesis with total denervation of the wrist.


Jean-Yves JENNY Rolf K. MIEHLKE Alexander GIUREA

Purpose of the study: Navigation systems have proven efficacy for implantation of total knee arthroplasty (TKA). Navigations have been accused of being complex, requiring a long learning curve. We compared the results obtained with the same navigation system in centers with experienced operators and centers with new operators.

Material and methods: Thirteen European centers participated in this prospective consecutive study. Inclusion criteria was indication for a TKA using a gliding prostheis with preservation of the posterior cruciate ligament. Four experienced cents(group A) with a mean experience of four years, and nine new centers (group B) with no prior experience participated in the study. The study concerned 403 TKA (182 in group A and 221 in group B). The main indications were primarily lateralized osteoarthritis. The navigation system was an imageless system based on intaoperative kinematic anatomic and kinematic analysis. A mobile plateau prosthesis was inserted. The following items were compared between the two groups: overall operative time and its variation over time, postoperative HKA, orientation of the femoral and tibial components in the ap and lateral views, complications and revisions.

Results: No significant difference was observed between the two groups for the preoperative items so comparison between the groups was licit. Correction of the frontal mechanical axis was satisfactory in 90% of patients in group A and 88% in group B (p> 0.05). There was no difference between the groups in quality of implantation for each prosthetic element on the ap and lateral views. There was no difference for rate of complications or reoperations. Longer operative time in group B disappeared after 15 implantations.

Discussion: The results from centers using navigation systems for prosthetic implantations shows that the performance in centers starting use is the same as in experienced centers. The only difference is an operative time slightly longer for the first 15 cases.


Mario RODRIGUEZ-SAMMARTINO

Purpose of the study: Accidents caused by power-take-off shafts produce different types of injuries. The lesions can vary from simple skin abrasion to amputation or serious, sometimes fatal, limb damage. We present a series of injuries treated in our institution since 1997 in order to analyze the circumstances of these accidents and their pathophysiological mechanisms as well as the most appropriate treatment. We also analyzed the mechanism of the power-take-off shaft with a few fundamental aspects to better understand the potential health hazard.

Material and methods: Ten victims of power-take-off accidents were treated in our institution since 1997. All were men aged 26 to 66 years. In all cases but one, a cord caught on the turning shaft was the cause of the accident. Eight of the patients presented upper limb injuries of variable gravity.

Results: Outcome after treatment depended on several factors: the severity of the injury, the circumstances of the accident and the proximity to a health care center. In general, the sequelae were worse for serious injuries, producing permanent disability.

Discussion: The power-take-off transmits power from the tractor to agriculture machines via a turning shaft. Correct use requires several safety measures. Serious injury, disability or death can result from inadequate protective measures or inadequate knowledge about proper use.


Jean-Yves JENNY Cyril BOÉRI

Purpose of the study: Navigation systems have proven their capacity to improve the quuality of total knee arthroplasty (TKA) implantation. The navigation system coud also be used to record knee kinematics intraoperatively.

Material and methods: Twenty TKA implantations were studied. The series included six males and 14 females, mean age 71 years (range 63–78 years). All underwent surgery for overall osteoarthritis. A TKA with a mobile plateau was implanted with preservation of the posterior cruciate ligament. The OrthoPilot® imageless navigation system (Aesculap, Tuttlingen, German) was used. The software was modified to enable recording the relative movement of the femur in relation to the tibia during flexion-extension movements. Infrared locators were fixed on the lower part of the femur and the proximal part of the tibia. After kinematic and anatomic acquisition of conventional navigation data, the kinematic recordings were made during passive flexion-extension before performing any procedures on the bones. The system recorded femur rotation in relation to the tibia in the frontal plane (varus-valgus), in the sagittal plane (flexion-extension), and in the horizontal plane (internal-external rotation) as well as anteroposterior translation of the femur on the tibia. The prosthesis was implanted using the conventional navigation technique. After implantation, the same kinematic recordings were repeated. Each measurement was taken in duplicate to study reproducibility in the same patient. Pre- and postoperative kinematic recordings in the same patient were compared to obtain objective evidence of changes induced by prosthesis implantation. The pre- and postoperative results were compared with those reported to date in the literature.

Results: The recorded kinematic curves, both before and after TKA implantation, were coherent with generally accepted values, particularly for rotation and antero-posterior translation. Paradoxical kinematic recordings were noted after implantation. There was no significant difference between the two recordings in the same patient.

Discussion: The software enables a reliable study of knee kinematics before and after TKA implantation. This could be useful to test new prosthetic solutions, but also to choose for a given patient, the best kinematic compromise. It would be interesting to compare these results with data on in vivo kinematic recordings made in the same patients.

Conclusion: Intraoperative kinematic analysis is a research tool at the present time, but could be useful to improve the quality of TKA implantations.


Bertrand GALAUD Mathieu MICHAUT Jacques-Marie ADAM Philippe BOISRENOULT Laure FALLET Olivier CHARROIS Philippe BEAUFILS

Purpose of the study: The purpose of rotating the femoral piece, using an indepenent cut strategy, is to «correct» for epiphyseal torsion of the distal femur and thus obtain a biepicondylar axis parallel to the posterior bicondylar axis. It is known however that epiphyseal torsion of the distal femur is highly variable from one individual to another. Intraoperative identification of the biepicondylar line enables appropriate rotation, as long as the data collected are reliable. The purpose of this study was to determine the reliability of intraoperative biepicondylar axis measurements made with navigation systems and to compare the results with the preoperative scan taken as the gold standard.

Material and methods: This prospective study included 60 degenerative knees undergoing total knee arthroplasty. The angle of epiphyesael rotation of the distal femur was measured on the preoperative computed tomography scan and intraoperatively with the navigation system which identified the biepicondylar line and the posterior bicondylar line. Statistical regression lines were determined.

Results: The rotation measured on the preoperative scan was 7.1±2.4° and by the intraoperative navigation system 3.2±4.3°. There was a very weak statistical correlation between the preoperative measurement and the intraoperative navigation measurement (p=0.234, R =0.320).

Discussion: Intraoperative identification of the biepicondylar axis is not reliable. Navigation does not enable an accurate assessment of the distal epiphyseal torsion of the femur and thus the proper rotation to give to the femoral piece. The only reliable measurement of the epiphyseal rotation of the distal femur is made on the preoperative computed tomography.


Mathieu MICHAUT Bertrand GALAUD Jacques-Marie ADAM Philippe BOISRENOULT Laure FALLET Olivier CHARROIS Philippe BEAUFILS

Purpose of the study: Recent studies have demonstrated that navigation systems provide highly accurate cuts for orthogonal alignment of the lower limb. The accuracy has not to our knowledge been assessed for rotation. Rotation of the femoral piece, which results from a strategy independent of the bone cut, is designed to «correct» for epiphyseal torsion of the distal femur and thus obtain a biepicondylar axis parallel to the «surgical» posterior bicondylar line described by Berger (line drawn between the medial sulcus and the lateral epicondyle), i.e. forming un angle of 2° with the anatomic biepicondylar line described by Yoshioka (line from the medial to lateral condyles). The purpose of this study was to access the precision of navigation rotation.

Material and methods: This prospective consecutive study included 40 osteoarthritic knees undergoing total knee arthroplasty (TKA). The anatomic angle of distal femoral torsion (Yoshioka angle: angle formed by the posterior bicondylar line and the biepicondylar line) was measured on the pre- and post(3 months)-operative scans. Navigation (Navitrack, Zimmer) used the rotation given by the preoperative scan to guide the femoral cut with the objective of achieving a residual Yoshioka angle of 2°, i.e. parallel to Berger’s surgical biepicondylar line. The postoperative HKA measured on the pangonogram in the standing position was 179.6±2° with 85% of patients between −2° and +2°, confirming the reliability of the navigation system.

Results: The mean preoperative epiphyseal rotation of the distal femur was 6.4±1.8°. The mean postoperative measurement was 1.1±2.4°. Eighty percent of patients were within ±2° of the objective.

Discussion: We demonstrated in previous work that navigation-based rotation using intraoperative data is satisfactory as long as the degree of rotation is based on the preoperative scan (and thus takes into account the wide rang of distal femur torsion). Navigation-based rotation is a progress compared with standardized rotation. The few errors observed were related to insufficient identification of the posterior bicondylar line during navigation or to difficulties in interpreting the postoperative scan.


Cyril BOÉRI Jean-Yves JENNY

Purpose of the study: Navigation systems have proven efficacy for the implantation of unicompartmental knee prostheses. Minimally invasive methods, which limit access to non-operated compartments, might compromise system accuracy.

Material and methods: A standard navigation software was used for kinematic acquisition of the lower limb and to acquire anatomic landmarks for both femorotibial compartments. A modified version of the navigation software designed for minimally invasive surgery replaed palpation of the anatomic landmarks of the non-operated compartment by a computation method based on other data. Three groups of patients were analyzed. Group 1 included 64 patients who underwent minimally invasive surgery for implantation of a medial unicompartmental prosthesis. Group B included 60 patients selected randomly among 140 cases of medial unicompartmental prosthesis patients treated with the standard navigation technique. Group C included 30 patients selected randomly among 180 patients who underwent total knee arthroplasty with the standard navigation system. The quality of the implantation was assessed on the postoperative ap and lateral views by comparing five criteria describing the desired prosthetic alignment. The number of criteria describing correct alignment was noted for each patient, thus yielding a quality score from 0 to 5. ANOVA was used to compare the mean scores of the three groups using Boneffini-Dunn correction at the 5% risk level.

Results: The mean quality score was 3.5±1.2 for group A, 4.5±0.8 for group B and 4.2±1.0 for grup C (p< 0.001). Ther was no significant difference between groups B and C (p=0.24). The quality score was significantly lower in group A (A versus B: p=0.015; A versus C: p< 0.001).

Discussion: The minimally invasive approach is proposed to enable more rapid functional recovery after implantation of a unicompartmental knee prosthesis. The long-term outcome however depends on the quality of the implantation. The quality of the implantation with a minimally invasive method should thus be equivalent to that achieved with the standard method. Conventional minimally invasive methods are more difficult. Navigation could be expected to overcome this difficulty without sacrificing implantation quality. However, the version used here did no enable an implantation equal to the quality achieved with the standard navigation system.

Conclusion: The standard navigation system for the conventional access remains the gold standard for implantation quality. Changes resulting from a less invasive approach should be validated before routine use.


Dominique SARAGAGLIA

Purpose of the study: The purpose of this study was to assess radiological outcome of double (femoral and tibial) osteotomy for severe genu varum. Between August 2001 and November 2004, eleven double osteotomies were performed amoung a series of 157 knee osteotomies (7%).

Material and methods: The series included four women and seven men, mean age 48.5 years (range 20–62 years). The right knee was involved in seven. One femal patient presented a particularly serious deformity but without oseoarthritic degeneration of the knee joint. The ten other patients all presented overtly degenerative knees. According to the Ahlback modified classification there were six grade III knees, three grade IV and one grade V. Mean preoperative radiological varus was 167.5±2.1° (ange 164–170°°. Orthopilot® was used in all cases. The first step was to insert percutaneously rigid bodies, one into the distal femur and the other into the proximal tibia. Kinematic acquisitions of the hip, the knee and the tibiotalar joint yielded the HKA for the lower limb. The second step was to perform the closed wedge lateral femoral osteotomy (5–6°) which was stabilized with an AO T-plate. The final step was to perform an open-wedge medial tibial osteotomy. After checking the desired alignment (182±2°) on the monitor, the osteotomy was fixed with Biosorb® and plated with an AO LCP.

Results: There were no complications. The mean intraopeartive HKA was 168.1±2.21° (range 164–170°), identical with the preoperative findings. After osteotomy, the mean angle provided by the computer system was 182.7±1.1° (range 182–184°). Three months after surgery, the mean alignment on the standing x-ray was 180.8±1.6° (range 177–182°). The preoperative objective was achieved for all knees but one (91% success). There were no x-rays with an oblique joint space.

Conclusion: Computer-assisted double osteotomy for major genu varum is a reliable accurate and reproducible technique. Use of a navigation simplifies a generally difficult procedure known to require much surgical skill to achieve the preoperative goal. This technique can be considered as an important development since it can help avoid an oblique joint space which can give rise to further problems and the need for a subsequent prosthesis.


Christian NOURISSAT Gérard ASENCIO Daniel BERTEAUX José ADREY

Purpose of the study: The natural history of congenital hip dysplasia with weight-bearing usually progresses towards degenerative joint disease. The anatomic type of the dislocation, whether treated or not, was well classified by Crowe who described four types.

Material and methods: Since 1989, we have used an ABG hydroxyapatite (HA) coated prosthesis for the treatment of congenital hip dysplasia. The hemispheric acetabular implant is coated with hydroxyapatite and the femoral implant, which is inserted in an anatomic position with anteversion, antetorsion and anteflexion, has a HA-coated stem. Forty-three Crowe type 3 or 4 hips (high position) were treated with this technique:

implantation of the cup in the paleoacetabulum;

screwed autograft harvested from the femoral head to fill the bony defect;

implantation of an anatomic stem, without cement but with HA-coated shaft.

Results: Cup implantation in the paleoacetabulum was achieved in all patients except two. A screwed autograft was inserted in 75% and remained stable over time for the larger grafts but tended to resorb for smaller grafts. For femoral anteverions, an ABG implant was used in 34 cases: 21 ABG1 stems, 11 ABF2 stems, and one ABG revision stem. The ABG stem enabled satisfactory anatomic restoration in 20 hips but with postoperative stiffness. For 14 hips, due to the important femoral anteversion related to the dysplasia, a reversed ABG-HA implant was used: eight left implants for right hips and six right implants for left hips. This «reversed» curvature gained 24° in the femoral anteversion plane. The outcome was excellent in these 14 cases, particularly with a clear improvement in postoperative external rotation. At close to 15 years follow-up we have had no case of femoral loosening, nor of femoral shaft osetolysis, with this type of implant.

Discussion: Certain authors propose using a custom-made implant for sequelar congenital hip dysplasia, but we prefer the proposed technique which provides very satisfactory results and limits the need for custom-made material.


Stéphane PLAWESKI Johan ROSSI Julien CAZAL Philippe MERLOZ Rémy JULLIARD

Purpose of the study: Anterior cruciate ligament (ACL) navigation systems are based on two underlying principles: «statistical» anatomic position and isometric anatomic (anatomometric) positioning. The purpose of this study was to demonstrate that an anatometric positioning of the transplant can be achieved, in other words, that the transplant can be positioned in the original anatomic air of the ligament insertion while preserving an optimal isometry without notch impingement. This study was also conducted to compare conventional systems with a computer-assisted system.

Material and methods: This study was conducted on thawed fresh-frozen cadaver knee specimens with > 120° flexion. The computer-assisted protocol for ACL surgery was applied to ten knee specimens. The original anatomic insertions of the ACL were dissected then inserted at the appropriate points into the computer display. The tibial and femoral insertion points of two classical aiming devices were recorded. These points were compared with the original anatomic insertion.

Results: For the tibia: classical aiming methods proposed a point of insertion posterior to the anatomic insertion for eight knees and within the frontiers of the anatomic insertion for two, in line with the anterior border of the posterior cruciate ligament. The computer-designated point of insertion for the tibial fixation was always within the anterior third of the ACL insertion, generally medially. For the femur, the transition (or isometric) line ran across the anatomic femoral insertion in all knees. It was observed that in all cases, the surgeon could choose an anatomic insertion with lesser anisometry by situating the insertion in the distal part of this line: for nine knees, the computer-designated femoral point was anatomic and with lesser anisometry. The Acufex aiming device produced better anisometry (my=4 mm) than the Arthrex device (my=6 mm) but with a less favorable anisometry curve.

Discussion: The notion of anatometry is compatible with computer-assisted surgery. This study demonstrated that the computer-designated tibial point of insertion is more anterior and medial than the conventional aiming points. This is a potential choice if the absence of a notch impingement can be visualized: Howel described a manual fluoroscopic method. In our opinion, at the present time, optimal choice of the femoral point to achieve the desired anisometric curve is strictly operator-dependent.


Julien CHOUTEAU Jean-Charles ROLLIER Ignaki BENAREAU Jean-Luc LERAT Bernard MOYEN

Purpose of the study: The correct position of the femoral and tibial tunnes for anterior cruciate ligament (ACL) reconstruction is a determining factor for favorable outcome. We used a novel computer-assisted system which enables intraoperative localization of the tunnel centers on the lateral view of the knee before drilling. This technique uses fluoroscopy combined with a passive system for computer-assisted image acquisition and processing to provide the surgeon with the desired positions. We report the anatomic and clinical results observed in a prospective series comparing this technique with the classical technique of independent blind tunnels.

Material and methods: Thirty-seven patients underwent computer-assisted surgery and 36 classical surgery without computer assistance performed by a senior surgeon. Mean patient age was 27 years in both groups. The patients were reviewed at mean 2.2 years (range 1–4.5 years). Data recorded included the KT-1000 laxity, radiographic drawer and the IKDC score (1999).

Results: Mean time from ACL tear to reconstruction was 30 months in both groups. Computer assistance increased operative time 9.3 minutes (range 4–13). The IKDC score was 67.9% A, 29.7% B, and 2.7% C in computer-assistance surgery patients and 60% A, 37.1% B and 2.9% B for classical surgery patients. The mean IKDC function score was 89.7/100 for the computer-assisted patients and 89.5/100 for the others. Mean manual maximal laxity (KT-1000) was 7 mm before surgery and less than 2 mm at last follow-up. Differential laxity was less than 2 mm in all patients who underwent computer-assisted surgery and in 97.7% of the others. The mean differential laxity for the medial compartment as measured on the postoperative stress films was 2.4 mm (range 0–12 mm) for computer-assisted surgery patients and 3 mm (range 0–10 mm) for the others. In the computer-assised surgery patients, the femoral tunnels were centered on a smaller area. There was not significant difference in the IKDC score, the KT-1000 findings and the stress x-rays between the two techniques.

Conclusion: The results of these two techniques in this report are similar to data reported in the literature. Computer-assistance enables more accurate and reproducible tunnel positioning with no significant clinical impact.


Guy MESSERLI Hassan SADRI Jean-Marie SCHOLLER Francis SONNEY Robin PETER Pierre HOFFMEYER

Purpose of the study: This was an analysis of long-term outcome of 260 consecutive total hip arthroplasty (THA) procedures performed with a press-fit CLS-Spotorno cup. This easy-to-position cup preserves bone stock if revision should be needed.

Material and methods: From January 1990 to December 1994, 260 THA were implanted with a CLS-Spotorno cup in 221 patients. The clinical and radiological outcome was assessed with minimal ten years follow-up. Mean age at operation was 63 years (range 26–82 years). Sixty eight patients (68 hips) died before ten years follow-up. Five patients (five hips) could not be transported for review and four patients (four hips) were lost to follow-up. This study thus concerned 183 Spotorno cups (70.3%) in 144 patients (65.1%) who were reviewed clinically at 120–166 months follow-up. One hundred twenty-five patients agreed to undergo a radiological work-up. X-rays were analyzed by several independent operators. Two hundred sixty prostheses were implanted by two senior surgeons using the transgluteal approach. The Harris score and the De-Lee-Charnley radiological assessment as well as the Kaplan-Meier survival curve were determined.

Results: Seven cups were revised (3.8%): three because of aseptic loosening, two during stem revision because of polyethylene wear, and two for recurrent dislocation. Radiographically, four cups (2.2%) had migrated and there was a lucent line adjacent to the cup in at least one of the three De-Lee-Charnley zones for 23 cups (12.5%). There were no cup wing fractures. The mean Harris score for 144 patients (183 hips) was 90 points (range 37–100) at last follow-up. Outcome was considered excellent for 123 hips (67%), good for 34 (18.5%), fair for 20 and mediocre for five. The Kaplan-Meier 10-year survival with revision as the end point was 99% (CI: 94.8–99.8%).

Discussion: The 10-year survival of CLS-Spotorno cups is excellent with a low rate of revision. These results can be tempered by the radiological findings, although the lucent lines were already visible on the 12-month x-rays with no visible progression.

Conclusion: This cup provides excellent long-term results with a survival curve comparable to other press-fit cups. It is easy to position and revise.


Sophie GROSCLAUDE Philippe ADAM Jean-Luc BESSE Rémi PHILIPPOT Michel-Henri FESSY

Purpose of the study: The iliopsoas bursa lies immediately anteriorly to the hip joint capsule and in certain cases there exists a natural communication between a hip prosthesis and the iliopsoas bursa, enabling formation of an inguinal mass by distension of the bursa.

Material and methods: We report six cases of a pseudo-tumoral mass which developed in the femoral scarpa triangle revealing a complication of total hip arthroplasty. These six patients, aged 66–79 years had their prosthesis for 11.5 years on average (range 4–20 years). Three had a history of acetabular dysplasia. All complained of pain. Five patients presented a palpable mass in the inguinal region. Two patients underwent emergency surgery, one for suspected strangulation of a crural herniation and the second for septic inguinal adenopathy. In two patients the clinical presentation was related to the local effect of the mass: lower limb edema with recurrent phlebitis due to venous and lymphatic compression, and femoralgia due to compression of the femoral nerve. The underlying prosthetic complications were: aseptic loosening (n=4), polyethylene wear (n=2), infection (n=1). All patients underwent revision surgery to change the prosthesis. The cystic formation was drained without resection. Symptoms resolved after replacement surgery in all patients.

Discussion: Palpation of an inguinal mass with signs of local compression in a patient with a painful total hip arthroplasty is a sign of a prosthetic complication (infection, loosening, wear). The diagnostic work-up should include bacteriology and plain x-rays of the hip joint. Bone scintigraphy may be contributive. Arthrography can demonstrate presence of a communication. Computed tomography provides the best visualization of the mass and its relations with neighboring organs. A duplex-Doppler is needed in all cases to search for thromboembolic complications prior to surgery. We chose not to resect the cystic formation in our patients, preferring treatment of the intra-articular cause. The fact that the mass and local its effects resolved in all cases with no recurrence at last follow-up leads us to recommend this attitude for typical presentations.


Stefan CRISTEA Vlad PREDESCU Florin GROSEANU Mihai POPESCU Dinu-Mihai ANTONESCU

Purpose of the study: Generally, hip prosthesis implantation for congenital hip dysplasia is a routine procedure.

Material and methods: We compared preliminary results between two surgical techniques. On one hand, hip prostheses were implanted via trochanterotomy with femoral shortening osteotomy for cemented insertion and trochanteroplasty. On the other, access was achieved via a triple infratrochanteric osteotomy for shortening, correction of valgum and derotation followed by implantation of a press-fit prosthesis without osteosynthesis.

Results:

Between 1993 and 2001, 61 patients underwent surgery for Crowe III or Eftekhar grade C hips (n=45) and Crowe IV or Eftekhar grade D hips (n=16). Mean patient age was 42 years. Prostheses inserted via the trans-trochanteric approach with femoral shortening osteotomy and cementing developed complications related to the trochanteroplasty: nonunion of the greater trochanter (n=6), functional impairment (n=2), infection after bursitis on suture and secondary necrosis (n=1). Because of these complications we adopted the triple femoral osteotomy technique for shortening, derotation and press-fit femoral implants.

Between 2001 and 2005, eight Eftekhar D hips were treated with this technique. Locked non-cemented femoral prostheses were inserted. Pre- and postoperative clinical assessment was based on the Postel-Merle-d’Aubigné score. For the cup, the technique remained unchanged, with cemented implants. The lengthening obtaine varied from 3.5 to 5.5 cm with no cases of sciatic palsy. There has been no case of prosthesis dislocation.

Conclusion: These preliminary results concern non-cemented femoral prosthesis with insufficient follow-up. We nevertheless have found this an attractive technique free of femoral complications.


Gilles BURDIN Arnaud JARRY Christophe HULET Bruno LOCKER Bertrand GALAUD Claude VIELPEAU

Purpose of the study: The objective of this retrospective analysis was to examine the functional and radiographic results of 33 resvisions for femoral implants using a long locked stem inserted without cement and coated with hydroxyapatite.

Material and methods: Mean follow-up was two years for 33 patient who underwent revison total hip arthroplasty (rTHA) with implantation of a press-fit long locked hydroxyapatite coated femoral stem (Aura or Linea) between 2000 and 2004. The explanted prosthesis was cemented in 23 cases. The reason for revision was femoral loosentng for 60%, femoral fracture for five pateints, and infection for two. According to the SOFCOT 1999 criteria, ten patients had bone defects score grade III or IV. Femorotomy was performed in 21 cases. Patients were reviewed clinically and radiologically. Function was assessed with the Postel-Merle-d’Aubligné (PMA) score and radiographic analysis determined the quality of osteointegration of the implants and the restitution of bone stock.

Results: There were six early complications (one death, one disloction with sciatic paralysis), and six late complications, mainly related to defective locking. The PMA score was less than 3 for only three patients. Twenty-six patients were satisfied or very satisfied and seven patients reported thigh pain which was generally moderate. The locking was released for five prostheses because of failure or pain (relief observed in three cases). Migration was noted in three cases, illustrating their non-integration. For 15 patients, corticalisation around the lower part of the prosthesis suggested implant mobility. This image was observed in all patients who complained of thigh pain (p=0.057). There was a significant increase in the cortical index, reflecting progression of the bone stock favoring the internal cortex.

Conclusion: This type of implant has provided a solution for the difficult problems of explantation and reimplantation of THA. These prostheses provide satisfactory short-term results and a significant improvement in bone stock. There remains the problem of osteointegration of certain implants. Technical factors can contribute to improved clinical results.


Jean-Louis ROUVILLAIN Damien RIBEYRE Abdelkarim OULDAMAR Claude SERRA Hugues PASCAL-MOUSSELLARD Olivier DELATTRE Yves CATONNÉ

Purpose of the study: The major functional impairment which results from femoral head necrosis in patients with sickle-cell anemia leads to implantation of a total hip arthroplasty (THA) in many of these often young patients. Intra- and postoperative complications are frequent.

Material and methods: In order to better understand the causes of these complications, and to search for ways of preventing them, we analyzed the cases of 35 sickle-cell anemia patients with 38 THA. Mean patient age was 36.4 years for these 22 women and 13 men. Twenty-eight patients had SS hemoglobin, five AS hemoglobin, and two presented sickle-cell-thalassemia (S-ß-hemoglobin). Mean follow-up was 7.6 years (range 2–29 years).

Results: Fifteen patients underwent revision surgery (39%) on average 4.8 years after primary implantation for loosening (n=13) or infection (n=2). Five other prostheses presented peripheral lucent lines (13%). The overall complication rate was 64% (shaft fractures, sickle cell crisis, dislocation or loosening, infection). One patient developed an early superficial infection which resolved. One other patient required revision for severe pain and prosthesis misalignment (flexion-external rotation) but with normal cell counts and a simply inflammatory synovial fluid. The presence of slowly progressive degenerative disease in a patient with severe pain should be carefuly identified before undertaking THA. Systematic samples are necessary. The femor-related complications in this series were: two intraoperative shaft fractures, one fracture below the stem during the first six months, and intraoperative shaft reaming in two. Femoral shaft morphological anomales must be identified preoperatively to enable a proper surgical plan. Small-size femoral stems should be available and zones of sclerosis in the canal must be identified. Cup-related complications are more difficult to analyze. The bony structure of the acetabulum was often remodeled, with very weak cancellous bone. Avivement of the acetabulum must be performed prudently manually or with a well controlled motor.

Discussion: Series report few cases in the literature, on average 22 cases (8–36). Mean follow-up was 5.1 years (range 4.6–9.5). The overall rate of complications was 42% (33–59) except for one series with only 2.8%. The rate of deep infection was 14.8% on average (0–36.4).

Conclusion: The decision to implant a THA in these young patients must be made conjointly with the patient. Multidisciplinary management before surgery is essential. Precise planning must take into consideration all the potential pitfalls. Special attention must be given to hemodynamic balance, intra- and postoperative oxygenation and the hemoglobin level.


François GAUCHER Olivier CHAIX Alexandre SONNARD

Purpose of the study: Implantation of a total hip arthroplasty (THA) for major misalignment is a difficult procedure and few results have been published. In the 1950s to 1970s, supra-trochanteric osteotomy was proposed for sequelar osteoarthritis of congenital hip dislocation. Subsequent degradation 20 to 30 years later can lead to neo-osteoarthritis of the joint with an effect on hip alignment and overall balance between the knee and the spine. We present a prospective consecutive series of 60 THA performed from 1991 to 2003on hips with Milch and Schanz osteotomies.

Material and methods: The objective was to reconstruct an anatomic hip joint by femoral re-alignment de-osteotomy, inferior displacement of the hip joint to enable insertion of an implant with a correctly position center of rotation and normal muscle lever arms. The technique was novel because of the direct approach to the subtrochanteric angle. The step by step procedure enabled insertion of the prosthesis without trochanterotomy. Overall recovery was long, often 12 to 18 months. There were 47 patients 60 hips) with at least 18 months follow-up. None of the patients were lost to follow-up.

Results: Results were available for 54 hips (three deaths, six hips). Mean follow-up was eight years. Outcome was good (patient satisfaction, normal x-ray) for 77%. Twelve hips presented poor clinical and radiological results due to loosening and mobilization of the femoral implant with or without nonunion of the deosteotomy. Ten hips were revised at mean five years via a femoral access for insertion of a press-fit distally locked prosthesis with graft of the nonunion (with acetabular replacement in one hip). The outcome was good at last follow-up for nine of these hips. One repeated revision gave satisfactory results.

Discussion: The only factors of risk of failure were related to femoral re-alignment and absence of trochanterotomy. A lesser risk of nonunion was related to the technique used for osteotomy, osteosynthesis and grafting. The use of a non-cemented implant with a solid primary stability and in certain cases a custom-made implant can be discussed for selected patients.


Anne LUBBEKE-WOLFF Guido GARAVAGLIA Pierre HOFFMEYER Thomas PERNEGER

Purpose of the study: Revision total hip arthroplasty (rTHA) is associated with higher mortality than primary total hip arthroplasty (pTHA). The functional outcome after rTHA is globally satisfactory but less so than with primary implantation. Nevertheless, data are scarce. Patients undergoing revision procedures are older and have more co-morbid conditions. In this context, we evaluated quality-of-life and patient satisfaction five years after implantation, comparing rTHA versus pTHA. We analyzed the impact of age, obesity, and co-morbid conditions.

Material and methods: The study cohort included all patients undergoing pTHA (n=471) OR rTHA (n=124) in our unit between 1996 and 2000. Five years postoperatively, we noted the Harris hip score (HHS) and patient satisfaction, assessed on a visual analog scale (VAS) from 1 to 10.

Results: The rTHA patients were older (72 yeras versus 68 years, p=0.004), more frequently obese (BMI30: 33% versus 19%, p=0.003) and presented more co-morbid conditions involving medical ( 2: 46% versus 21%, p< 0.001) and orthopedic ( 2: 13% versus 7%, p=0.053) problems. Five years after surgery, quality-of-life and patient satisfaction were much lower after rTHA than after pTHA (HHS < 70; 31% versus 9%, p< 0.001; satisfaction score 8: 68% versus 85%, p< 0.001). Adjustment for the preoprative status (ASA, medical and orthopedic comorbidity, BMI, gender, age) attenuated these differences which nevertheless remained significant [non-adjusted HHS difference: 11.5 (95%CI: 7.4–15.7); adjusted difference: 8.8 (95%CI: 5.5–12.1)]. In both groups, a low HHS was associated with BMI ≥ 30, poor preoperative function, 2 joints affected, elderly age. Obesity was associated with even poorer results after rTHA than after pTHA (non-adjusted difference, p=0.026).

Discussion: Quality-of-life and patient satisfaction at five years were clearly poorer after rTHA than after pTHA. This is in agreement with data in the literature. The difference is explained in particular by greater patient age and more associated comorbidities for rTHA. Obesity is a prognostic factor which is more unfavorable after rTHA than after pTHA.

Conclusion: Considering the risks and benefits of revision surgery, it is important to recognize not only the surgical factors but also the characteristic features of the patients.


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Jean-Louis DORÉ

Purpose of the study: This series included 50 consecutive cases of titanium hydroxyapatite coated cups impacted directly on live bone of the neoacetabulum after removal of a loosened cup implanted and reviewed at more than ten years.

Material and methods: The goal was to insert a titanium hydroxyapatite-coated cup on the largest quantity of healthy cancellous bone in the neocavity without using a graft and without worrying about the future height of the center of rotation nor the medial offset. The shortened impaction related to the neoacetabulum formed by the loosening could be compensated for by descending the femoral stem a bit further. This method of acetabular revision was performed for 75 hips before 1993. At more than ten years follow-up, four hips were lost to follow-up, 20 patients had died, and one case of early suppuration was noted. The series thus included 50 cups in 48 patients (22 men and 26 women, mean age 67 years at revision surgery). The Charnley classification was: A:21, B:22, C:7. Mean follow-up was 11 years. The SOFCOT staging was: I=0, II=33, III=14, IV=3. AAOS I=0, II=32, III=18, IV=0. The number of prior cup replacements: 0=46, 1=4. Approach: trochanterotomy (n=44), femorotomy (n=0), posterolateral alone (n=6). Mean cup diameter 60 (range 48–68). Femoral stems changed = 20. Preoperative PMA = 12 and postoperative PMA = 16.

Results: Among the 50 hips, 48 exhibited optimal fixation without lucent line or bone defect. One patient presented a partial lucent line and one had revision at nine years. At five years, all cups (100%) were in place and at ten years 98%. There were no cases of pelvic fracture and only three stage IV hips.

Discussion: The advantages of this method are to avoid the use of a graft or frozen head, and the generally immediate/rapid weight bearing. This series raises the question of whether it is advisable to replace the new cup in the position of the paleoacetabulum. These implants can be improved with screwed cups onto which a double-mobility cup can be press-fit. This technique has enabled weight-bearing in conditions which otherwise would not have been possible for these frail elderly patients.

Conclusion: In light of this consecutive series reviewed at more than ten years, we have decided to continue this approach.


Bernardo VARGAS-BARRETO Patrick REYNAUD Jacques-Henri CATON

Purpose of the study: Loss of acetabular bone stock is a very common finding at revision total hip arthroplasty (rTHA). The acetabular bone defect can be filled with an autograft or with cyropreserved or lyophilized and radiated allografts. The permanent availability lypophylized radiated allografts is a certain advantage. For more than ten years (1994), we have used Phoenix® (TBF) lyophylized radiated bone grafts.

Material and methods: We conducted a retrospective study of all patients who underwent rTHA for aseptic loosening between 1994 and 1999 with replacment of the acetabular implant requiring use of a lyophyilized radiated allograft (TBF, Phoenix®) fashioned from femoral heads and cut to fit. Grafts were impacted followed by acetabulra replacement with a cemented polyethylene (PE) cup or a Kerboull retaining ring, or an ace-tabular grid as needed. This procedure was used for 18 hips (16 patients). The Postel-Merle-d’Aubigné (PMA) clinical score and radiographic assessment were noted at five years with the Paprovsky classification. In addition, the status of the allograft (homogeneous aspect) and the presence of a lucent line between the host bone and the allograft were noted.

Results: One patient was lost to follow-up. The analysis thus included 17 of 18 hips. Mean age was 63 years at rTHA surgery and 55 years at primary surgery. The reason for revision was cup loosening (n=13), isolated PE wear (n=4) with acetabular bone defects. The mean preoperative PMA score was 10.4 (range 5–18). At three months, the PMA score was 15.2 (range 12–18), at one year 16.2 (range 15–18), and at five years 17.2 (range 16–18). Implant migration was not observed on the five-year x-rays. Allografts were incorporated for seven hips which presented a homogeneous graft image. Five hips presented a partial lucent line and five a complete lucent line but with no evidence of implant instability. None of the patients required surgical revision to change the implant or for a new bone graft.

Discussion: Acetabular revisions are often associated with bone defects which can be filled with allografts. This study demonstrated the good incorporation of lyophilized radiated allografts. This incorporation is progressive with good implant stability at more than five years. Use of this graft material for filling acetabular defects can correct for the bone deficiency.

Conclusion: Use of lyophilized grafts gives satisfactory results with reliable outcome at five years comparable with other bone replacement methods, particularly cyropreserved femoral grafts used before 1994.


Elhadi SARI ALI Philippe LÉONARD Patrick MAMOUDY

Purpose of the study: Dislocation of a total hip arthroplasty (THA) is a common complication, the third leading reason for revision. Anterolateral approaches produce the lowest rate of dislocation but have many drawbacks. Few studies have examined the rate of dislocation of THA implanted via an anterior approach such as described by Hueter which appears to be more anatomic and less damaging. The purpose of this study was to determine the rate of dislocation of THA implanted via this approach and to search for associated risk factors.

Material and methods: A prospective study included 1764 THA in 1374 patients, 891 females and 483 males, implanted between 1997 and 2003. Age ranged from 22 to 84 years (69±10.8). The right side was involved in 996 cases and the left in 768. Two senior surgeons performed the operations using the anterior approach described by Hueter. A cemented implant with a metal-backed polyethylene cup was used. The group of patients who presented at least one dislocation was compared with the group of patients free of dislocation. The effect of clinical, radiolgical, and prosthetic factors was studied: age, gender, body mass index, etioloy, intraoperative blood loss, head diameter, cup inclination and anteversion. Pearson’s chi-square test and Student’s t test were applied with a 5% level of significance.

Results: The rate of dislocation was 1.5% (27 patients). The rate of dislocation after discharge to home was 0.8%. All dislocations occurred early, from postoperative day 1 to 56, mean 13.8 days (SD 15.25). One patient underwent revision for reduction. Two underwent revision for recurrent instability (0.11%). Significant risk factors were male gender (p< 0.001), young age (p< 0.001), elevated body mass index (p< 0.001), osteonecrosis (p< 0.001), significant intraoperative blood loss (p< 0.001), head diameter 22.22 vs 28 (p< 0.001).

Discussion: The Hueter approach significantly reduces the risk of dislocation. This might be explained by the less invasive nature of the approach since it does not require any muscle section.

Conclusion: The risk of dislocation after implantation of a THA via the anterior Hueter approach is one of the lowest reported in the literature (0.8% after discharge to home). Subjects at risk are five years younger, overweight males operated on for osteonecrosis with significant intraoperative blood loss and a 22.22 diameter femoral head.


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Maher KARRAY Ramzi BOUZIDI Ridha SALLEM Abdelaziz ZARROUK Hamadi LEBIB Khelil EZZAOUIA Mondher KOOLI Mongi ZLITN

Purpose of the study: Transversal or «U» fractures of the sacrum are rare. Reported for the first time by Bonin in 1945, such fractures concern less than 1% of spinal fractures. Initially, these injuries were often missed despite their association with neurological disorders such as caudia equina syndrome. This late diagnosis is related to the context of multiple trauma and also to insufficient knowledge of this type of injury. The purpose of this study was to draw clinicians’ attention to this type of injury in order to favor early diagnosis and appropriate treatment.

Material and methods: This series included nine cases observed from 1999 to 2002. Mean age was 32 years, range 17–80. Female gender predominated (two-thirds of the patients). Six patients were fall victims, (suicide attempts or scaffold accidents). For eight patients, neurological signs involved a complete S1 or S2 caudia equina syndrome. L5 paralysis was noted in one patient due to a far-out syndrome. The diagnosis was established late in four patients, 2 to 45 days after trauma. Surgical treatment was instituted for six patients with neurological disorders diagnosed early. Treatment consisted in fracture reduction, posterior decompression and posterolateral stabilization. Intraoperative exploration revealed caudia equina contusion and compression in five of six patients with no loss of continuity. The sixth patient presented nearly complete root section.

Results: Eight of the nine patients were followed and reviewed at 2 years 4 months on average. The patient with a root section committed suicide four months postoperatively. Neurological recovery was complete for the five other patients who underwent surgery. Motor, sensorial and sphincter function and the urodynamic study were normal at last follow-up. L5 paralysis recovered last. For the two non-operated patients, only one achieved partial recovery.

Discussion: U fracture of the sacrum is a triple plane fracture which is difficult to explore with plain x-rays. In the context of a multiple trauma victim or attempted suicide, neurological complications are difficult to detect, further retarding the diagnosis of fracture. Roy Camille, Coutallier, Hessman report frequent misdiagnosis of the initial fracture and emphasize the contribution of computed tomography for correcting the diagnosis and establishing the surgical strategy. Surgery is the best option for improving prognosis, both in terms of neurological recovery and lumbopelvic stability.

Conclusion: Emergency physicians, neurosurgeons and orthopedist should be aware of U fractures of the sacrum, particularly in high-energy fall victims. A better clinical approach, particularly systematic examination of the perineum, is the key to successful diagnosis and proper orientation of the x-ray work-up to establish a positive diagnosis and improve the therapeutic approach.


Thibaut LENOIR Etienne HOFFMANN Etienne MOREL Nicolas LEVASSOR Ludovic RILLARDON

Purpose of the study: We present a review of the two-year outcome of a new clinical sacroiliac fixation technique used in our first seven patients.

Material and methods: Between May 2002 and March 2003, seven patients with a Tile C fracture of the pelvic girdle were stabilized with a new operative technique. This technique used two sacral screws linked to two iliac expansive screws via a 5.5 mm rod. Three of the patients presented preoperative neurological injuries attributed to the trauma (L5 or S1 paralysis). All presented associated lesions: lower limb (n=3 patients), spine (n=2), acetabulum (n=2). Mean patient age was 36.3 years. We present a retrospective clinical and radiological review of these seven cases. The Majeed score, the radiological index of lower limb length, and the combined index of vertical displacement and sacroiliac CT results were noted.

Results: The mean Majeed score was 93. Reduction of the combined vertical displacement was considered excellent or good (< 10 mm) in all patients; The reduction in the leg length discrepancy was considered good for all patients. There was no loss of reduction at last follow-up. There were no septic or skin complications and no complications related to implanted material. The implants were removed in one patient. The sacroiliac CT revealed formation of ossification bridges in all patients.

Discussion: The results of our small series are encouraging, particularly for vertical stability over time. There was no case of lysis around the screws and the clinical results were satisfactory.

Conclusion: For us, this technique is the optimal method for the treatment of Tile C injury to the pelvic girdle. This technique enables vertical stabilization while maintaining a certain degree of horizontal mobility facilitating reduction and fixation of the associated anterior injuries. This technique has its limitations since it is not particularly adapted for posterior lesions with fracture of the sacrum in Denis zone 2. These early encouraging results will require further long-term assessment in a larger group of patients.


Alexandre NEHME Arlen HANSSEN David LEWALLEN Joseph WEHBE Ghassan MAALOUF Jean PUGET

Purpose of the study: The majority of acetabular bone defects observed during revision hip surgery can be treated with a hemispheric implant, associated or not with a bone graft. In many patients however, loss of bone stock is so great that a more complex system must be used with a sustaining ring, multilobulated implants, or massive allografts. All have their technical difficulties or problems with fixation. The purpose of this work was to evaluate a new technique for acetabular reconstruction using modular implants fashioned with a new biomaterial, porous tantalum, which had specific properties favoring osteointegration.

Material and methods: These modular implants were fashioned so as to enable reconstruction of the acetabular cavity in cases with complex loss of bone stock. The design allows simultaneous biological incorporation and mechanical support with a press-fit hemispheric cup. These implants were used for 16 hips (16 patients, 12 women and 4 men, mean age 63.6 years, age range 34–86 years). These patients were followed for 31.9 months on average (range 24–39 months). The acetabular defects were Paprosky 2A (n=1), 2B ‘n=3), 2C (n=1), 3A (n=5), 3B (n=6). On average, these patients had undergone 2.8 cup replacements (1–9) on the same hip.

Results: The mean Harris hip score improved from 39.31 (range 33–52) preoperatively to 75.18 (range 52–92) at last follow-up. Preoperatively, the center of rotation of the prosthetic hip was situated a a mean horizontal distance of 18.6 mm (range −3 to 46 mm) and a mean vertical distance of 27.6 mm (range −16 to 52 mm) from the ideal center of rotation according to Ranawat. Postoperatively, the prosthetic center of rotation was situated at a mean horizontal distance of 10.5 mm (range 1–25 mm) and a mean vertical distance of 7.4 mm (range −15 to 25 mm) front the ideal center of rotation. None of the implants presented loosening or migration at last follow-up.

Discussion: At short-term follow-up, this modular system for acetabular reconstruction has provided good results for acetabular reconstruction which can accept a hemispheric cup alone and which would have required use of other reconstruction methods such as structural allografts, sustaining rings or other.

Conclusion: A longer follow-up will be needed to determine whether these good clinical and radiological results persist with time.


Jean-Yves BEAULIEU Chirstophe OBERLIN Jean-Paul ARNAUD

Purpose of the study: Surgical management of neurological injury encountered in patients with a ruptured pelvic girdle remains exceptional. In this work, we present our experience and compare our results with data in the literature.

Material and methods: This retrospective analysis concerned four clinical css. Mean patient age was 20.2 years for two men and two women. All patients were victims of high-energy trauma and presented type C (Tile) pelvic girdle injury. All presented a paralysis of the lumbosacral plexus. One patient presented bilateral paralysis of the pudendal plexus. The work-up included: saccora-diculography, myeloscan, lumbar magnetic resonance imaging. One patient presented a pseudomeingocele.

Results: Surgical exploration was performed within a mean delay of 3.75 months. Two types of exploration were used: for two patients the transperitoneal approach was used because of a suspected lesion of the lumbosacral trunk and for two others, the trans-sacral approach because of suspected intra-spinal rupture. Neurolysis was performed for three patients and an caudia equina nerve graft for one. Nervous injuries involved section or rupture of the roots. There were no cases of medullary avulsion. All patients presented signs of nerve regeneration at last follow-up (mean 5.5 years).

Discussion: Even though injury to the lumbosacral plexus is exceptional, advances in surgical techniques offer therapeutic options adapted to each type of injury and nerve territory. One or more motor functions can be restored. Microsurgical nervous repair of the lumbo-sacral plexus is possible irrespective of the level of the injury. Nerve repair by grafting or neurotization can be achieved via a combination of trans-sacral and anterior retroperitoneal approaches or even a transabdominal approach.


Benoit GIRAUD Emile DEHOUX Karim MADI Alain HARISBOURE Philippe SEGAL

Purpose of the study: To compare the DHS plate fixation with the Targon PF nail for the treatment of intratro-chanteric fractures.

Material and methods: This was a prospective randomized study including 60 patients hospitalized in the emergency setting between December 2003 and June 2004for intratrochanteric fractures. The AO classification was used. We analyzed: patient status (ASA), operative time (type of implant, duration), the postoperative period (blood loss, radiologic findings, duration of hospital stay, early postoperative complications) and at last follow-up, Harris hip score, date of resumed walking, mortality. Patients were assessed at three months postop. This study included 60 patients, 34 with a Targon PF nail and 26 with a DHS. Mean patient age for nailing was 81 years (SD 12.8, range 23–86); for DHS it was 82 years (SD 9.8; range 47–97).

Results: Mean blood loss was 410 ml with the Targon PF nail and 325 ml with the DHS, a nearly significant difference (p=0.07). The other results did not demonstrate any significant difference. At three months five cases of screw cut out were noted. Bone healing was achieved in all cases. The Trargon PF nail and the DHS provide equivalent results, with less bleeding an lesser cost for the DHS.


Mathieu THAUNAT Philippe PAILLARD Frédéric LAUDE Gérard SAILLANT

Purpose of the study: Pelvic fractures disrupting the pelvic girdle often create a serious challenge for reduction and fixation. Type C fractures of the Tile classification provoke vertical instability. Percutaneous screw fixation under fluoroscopic control in patients positioned in dorsal decubitus enables an extension of early indications for fixation to patients with abdominal or thoracic injuries. The reduction is obtained by progressive transcondylar traction on an orthopedic table. The purpose of this study was to assess functional mid-term outcome and to analyze causes of failure.

Material and methods: From 1995 through 2003, we used the percutaneous sacroiliac screw fixation method for type C fractures in 25 patients; clinical assessment at 45 months mean follow-up was available for 22 patients. Six patients presented a bilateral lesion (C2), seven a vertical sacral fracture (C1-3), and nine sacroiliac disjunction (C1-2). One screw was inserted for ten patients, two screws for twelve. Complementary anterior osteosynthesis was performed for eight patients.

Results: The functional outcome was assessed with the Mageed score. The mean score was 801%. All patients presente satisfactory postoperative reduction (less than 10 mm residual vertical displacement). Early displacement was noted one day 10 in one patient who underwent a revision procedure. There were two late secondary displacements (one with mobilization and one with material fracture) which heal in a misaligned position. There were no iatrogenic complications (neurologic, vascular, infectious) and no cases of nonunion.

Discussion: The long-term functional results were directly related to the quality of the reduction, as previously demonstrated by Matta. In our series, the quality of the postoperative reduction was significantly correlated with time from trauma to surgery. This delay must be as short as possible (less than five days for Routt). The main complication was secondary displacement which was observed in this study among cases with a single posterior screw.

Conclusion: Percutaneous sacroiliac screw fixation provides good functional results and appears to be a safe technique if the initial reduction is satisfactory. Two posterior screws are needed to avoid secondary displacement.


Alexandre POIGNARD Paolo FILLIPINI Olivier MANICOM Gilles MATHIEU Ali DEMOURA Philippe HERNIGOU

Purpose of the study: This retrospective analysis compared surgical treatments of femoral neck fractures in patients aged over 80 years.

Material and methods: Two hundred femoral neck fractures (Garden 3 and 4) were treated in three different manners: total prosthesis with a retaining cup (74 patients), intermediary prosthesis (58 patients), and osteosynthesis (68 patients). Indications were the same, but the periods of treatment were successive. Study variables were: mortality, number of revisions, duration of hospital stay, discharge to home or rehabilitation center, cost per hospital day. Follow-up was at least two years. The chi-square test was applied with p< 0.05.

Results: Mortality was similar for the three groups: eight deaths during stay in orthopedic unit (4%), three after total prosthesis (4%), three after osteosynthesis (5%) and two after intermediary prosthesis (3%). The difference was nonsignificant (p=0.24). Among the total prostheses, five dislocations (6.7%) required anesthesia despite the retaining cup. The rate of dislocation was 12% for intermediary prostheses and to avoid recurrence four revisions were needed to totalize an intermediary prosthesis with a retaining cup. Among the osteosynthesis cases, the rate of revision was 25%; transformation to a total prosthesis was necessary for 17% and material removal with resection of the head and neck was necessary in 8%. One total prosthesis and one intermediary prosthesis had to be removed because of infection. Resection of the head and neck for infection also occurred in one patient with an intermediary prosthesis. The rate of revision for an orthopedic problem was significantly less (p< 0.01) in the total prosthesis group. At last follow-up, or before death, patients with a total prosthesis were more independent and returned to their home significantly more often than patients treated with osteosynthesis. The economic cost of these interventions were not significantly different, the cost of the implant being insignificant compared with the cost of hospitalization and reeducation of this very elderly population.

Discussion: Total hip arthroplasty is a recognized treatment for painful degenerative hip disease. Historically, the total prosthesis was not considered as a first-intention treatment for fractures of the femoral neck in elderly subjects due to the risk of intraoperative blood loss, the risk of infection, and the risk of dislocation if a hip stabilization mechanism was not applied. This study demonstrated that, in light of the complications observed with the other methods, progress in anesthesia and use of implants avoiding dislocation can be proposed as first-intention treatment for total prosthesis patients who suffer a fracture of the femoral neck.


Marc-Antoine ROUSSEAU Frédéric LAUDE Gérard SAILLANT

Purpose of the study: Misalignment after insufficient treatment of unstable fracture of the pelvis is often poorly tolerated, compromising quality-of-life due to limping, leg length discrepancy, posterior pain, uncomfortable sitting position and/or sexual disorders due to mechanical problems. Secondary surgical treatment can be proposed despite its invasive nature (generally three phase surgery). The purpose of this work was to present the technique and the results of standardized correction of pelvis misalignment using a two-phase procedure.

Material and methods: Eight consecutive patients (May 2002–May 2004) with sequelae of Tile C fractures were treated on average eight years after the initial trauma. A double-approach was used. The series included four men and four women, aged 18–43 years. The first posterior approach in the ventral supine position was used for osteotomy of the sacroiliac callus and systematic debridement by section of the sacroiliac ligaments. The secondary ilioinguinal approach was performed in the dorsal supine position to achieve osteotomy of the symphyseal callus, reduction of the iliac wing, and symphyseal synthesis using a sacroiliac plate anteriorly and percutaneous screws.

Results: The mean operative time was four hours 30 minutes. Blood loss required transfusion of 3.5 packed red cell units on average. Anatomic reduction was achieved in six cases, partial reduction in two. Despite one nosocomial infection and two partial popliteal external sciatic deficits, all patients wer satisfied with the operation at mean eight months follow-up. Bone healing was achieve din all cases.

Discussion: Standard two-phase surgery is possible for a wide range of cases. The anatomic result is reliable with good clinical outcome. The duration of the operation and blood loss are reduced compared with classical techniques.

Conclusion: Despite the advantage of this original operative strategy, surgery for correction of pelvis misalignment remains a difficult surgical procedure for selected and motivated patients informed of the operative risks.


Laurent GALOIS Yves STIGLITZ Stéphanie VALENTIN Jacky GASNIER Didier MAINARD

Purpose of the study: Percutaneous compression plating (PCCP) is a new method for minimally invasive fixation of intratrochanteric fractures. Fixation is achieved with two neck screws and a 3-hole plate. This prospective study of a non-randomized series was designed to compare results in a monocentric cohort of patients treated by PCCP or dynamic hip screw (DHS).

Material and methods: From September 2003 to December 2004, all patients presenting an A1 (75.8%) or A1 (24.2%) (AO classification) intratrochanteric fracture were treated with PCCP (n=37) or DHS (n=20). Female gender predominated (86.5%) in this elderly population, mean age 83.2 years. The following variables were studied: operative time, radiation time, blood loss, hemoglobin level, blood transfusion, bone healing, complications, quality of the reduction.

Results: Mean follow-up was 8.3 months. The two groups were similar regarding bone healing, functional outcome and mortality. Intraoperative blood loss was less with PCCP (63 ml) than with DHS (120 ml). Mean fall in hemoglobin level was 2 after PCCP and 3 after DHS. The transfusion rate was 28% for PCCP and 40% for DHS. Mean operative time was 50 for PCCP and 30 minutes for DHS. Men radiation exposure was 4 minutes for PCCP and 1 minute for DHS. The positions of the screw (DHS) and the two PCCP screws were considered good for 68% of the PCCP and 75% of the DHS, acceptable for 29% PCCP and 20% DHS, and poor for 3% PCCP and 5% DHS. Complications were similar (one disassembly in each group).

Discussion: Although this was a preliminary study, PCCP was found to provide an attractive alternative for the treatment of intratrochanteric fractures. Results are similar to those obtained with the DHS but with a less aggressive method (limited approach, less blood loss). A learning curve (at least 10 implantations) appears indispensable to achieve maximum skill. The main drawback is the duration of the radiation. This implant would not be acceptable for subtrochanteric fractures which would require another type of implant.


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Guillaume HERZBERG Xavier GUEFFIER Marco LANZETTA Cyril FALAISE Aram GAZARIAN Jean-Michel DUBERNARD

Purpose of the study: The purpose of this work was to report our experience with three patients who underwent hand transplantation procedures following traumatic amputations.

Material and methods: The three patients underwent surgery in 1998, 2000, and 2003. One hand was transplanted in one patient and two in two patients. The technical principles of autologous macro-re-implantations were applied. The re-implantation level was the forearm in all cases. Medical treatment prescribed for life was similar to treatments currently used for renal transplantation (tacrolimus, mofetil mycophenolate and prednisolone).

Results: After an apparent initial success, the first transplanted patient (one hand) had to be re-amputated 2.5 years later due to poor tolerance and poor treatment observance. For the two patients transplanted (two hands for both) in 2000 and 2003, the functional outcome in terms of recovered sensitivity (tact), motricity, and function were quite satisfactory in light of the handicap of bilateral amputation. Immunosuppressor treatment was well tolerated at 1.5 and 4.5 years respectively.

Discussion: Due to the lack of prior experience reported in the literature, we examined the risk-benefit ratio of these re-implantations which must still be considered as clinical experimentation. It is important to consider the potential benefit of myoelectric prostheses as well as the known complications related to immunosuppressor treatments. Patient motivation is also an important factor to consider.

Conclusion: These three cases demonstrate that the outcome of orthopedic composite tissue allografts in patients given immunosuppressor therapy is quite variable at less than four years follow-up. Experience with a larger number of patients will be necessary before broadening potential indications.


Fabrice DUPARC Jocelyn OZEEL Maxime NOYON Antoine GEROMETTA Chantal MICHOT

Purpose of the study: Compression of the suprascapular nerve in the superior or inferior scapular incisures is a well-known syndrome compression syndrome triggered in the narrow osteofibrous tunnel. This study was undertaken after observing several cases of nerve compression in the supraspinatus fossa after neruolysis procedures. We wanted to better understand the relations with the supraspinatus fascia.

Material and methods: Thirty human cadaver shoulders were dissected. After exposing the supra and infraspina-tus fossae and section of the scapular spine, the supra and infraspintus tendons were sectioned and folded back medially to expose the suprascapular pedicle in the superior scapular incisure, the supraspinatus fossa, and the inferior scapular incisure. The presence of a fascia sheathing the nerve, of subfascial tissue, and of a transversal inferior (spinoglenoid) ligament was noted together with the histology of the observed structures.

Results: A supraspinatus fascia sheathing the nerve was observed in 29 dissections. This fascia was inserted on the superior border of the scapula and the superior scapular ligament and the floor of the supraspinatus fossa. Diffuse adipose deposits under the fascia was observed in 55.5% of the dissections, or located around the vasculonervous bundle in 44.5%. There was a fibrous buttonhole facing the lateral border of the spine in 28 shoulders with a thickened zone which constituted histologically the equivalent of an inferior transvers ligament in 26 shoulders. One subfascial lipoma was discovered.

Discussion: Sheathing with a supraspinatus fascia could explain suprascapular nerve compression in the supra-spinatus fossa where the nerve is exposed to compression against the bony base on which it runs between the superior and inferior incisures. These anatomic data suggest that suprascapular neurolysis should release the nerve over its entire length and not just at the superior or inferior scapular incisure.

Conclusion: The succession of the superior transverse ligament, the supraspinatus fascia, and the inferior transverse ligament constitutes an osteofibrous tunnel which should be considered as a potential source of a suprascapular tunnel syndrome at three levels.


Séverin ROCHET Laurent OBERT Daniel LEPAGE Josette VERDENET Jean-Claude CARDOT Guy MONNIER Yves TROPET Patrick GARBUIO

Purpose of the study: Occult fractures of the carpal bone are underestimated. An undetected fracture of the scaphoid will not be immobilized and will lead to nonunion and osteoarthritic degradation. In order to avoid late diagnosis and functional loss, in addition to lost chances and legal suites, we validated a quantitative radioscin-tigraphic (QRS) tool in a randomized prospective trial conducted from 1997 to 2003 in a routine practice setting. The series included 667 patients with wrist trauma presenting a normal plain x-ray one day 0. After day 8 these patients underwent QRS.

Material and methods: The principle of the technique consists in a classical technetium scintigraphy with two technical improvements:

quantification of uptake: uptake two-fold greater on the injured side is a sign of «certain» fracture;

software superposition of the scintigraphic image and the radiographic image used to localize the bone fracture.

Results: Forty percent of the wrist trauma patients (260/667) with a normal plain x-ray presented an occult fracture (uptake > 2 on QRS). QRS was performed on day 17.7 on average. Fractures of the scaphoid were the most frequent (42%). The uptake ratio was higher if the QRS was performed from day 11 to day 20. Statistical analysis showed that uptake ratio > 2 was independent of age, gender, bone volume, and time to QRS.

Discussion: As demonstrated by Dikson, Dias, Thomp-son and Kuckla, repeated x-ray images do not increase the rate of diagnosis of carpal bone fractures. Spitz demonstrated that scintigraphic uptake on the trauma side more than twice that on the healthy side is a sign of fracture. Garbuio, NOvert and Lepage validated QRS as a sensitive and specific diagnostic tool for occult fractures. They demonstrated that QRS is less costly, more reliable than MRI and that there are no false positives.

Conclusion: Exploration of a «bone problem» in a patient with wrist trauma must not ignore sensitive and specific tests. Ultrasonography is operator-dependent and requires validation. We thought that QRS would not resist the development of routine MRI, but observed the contrary. QRS remains the gold standard diagnostic tool for ruling out a fracture of the carpal bones.


Hocine BENSAFI Gérard GIORDANO Jean-Michel LAFFOSSE Charles DAO François-Loïc PAUMIER David JONES Jean-Louis TRICOIRE Vincent MARTINEL Philippe CHIRON Jean PUGET

Purpose of the study: Percutaneous compressive plating (PCCP) enables minimally invasive surgery using closed focus technique. We report a prospective consecutive series of 67 fractures (December 2003 – February 2005) followed to bone healing.

Material and methods: Mean patient age was 83 years (range 37–95) with 83% females in a frail population (ASA 3, 4). Two-thirds of the patients had unstable fractures (AO classification) which were reduced on an orthopedic table under fluoroscope. Two minimal incisions were used to insert the material without opening the fracture and without postoperative drainage. Blood loss was noted. Verticalization and weight bearing were encouraged early depending on the patient’s status but were never limited for mechanical reasons. Patients were reviewed at 2, 4 and 6 months.

Results: Anatomic reduction was achieved in 84% of hips, with screw position considered excellent for 45, good for 14, and poor for 6. There were no intraoperative complications. The material was left in place. The hemoglobin level fell 2.2 g on average. Mean operative time was 35 minutes and the duration of radiation exposure 60 seconds. Mean hospital stay was 13 days. General complications were: urinary tract infections (n=10), phlebitis (n=2), talar sores (n=5). Gliding occurred in three cases (4%) with telescopic displacement measuring less than 10 mm in ten cases. There were two varus alignments with no functional impact. There were four deaths within the first three weeks. All fractures healed within three months.

Discussion and conclusion: PCCP has its drawbacks (mechanical, stabilization) as do all osteosynthesis methods used for trochanteric fractures. The technique is reliable and reproducible and is indicated for all trochanteric fractures excepting the subtrochanteric form. PCCP has the advantage of a closed procedure with a minimal incision and limited blood loss for a short operative time. An advantage for this population of elderly frail subjects (ASA 3, 4). PCCP enables immediate treatment with a low rate of material disassembly compared with other techniques.


Jean-Yves BEAULIEU Sébastien DURAND Zulmar ACCIOLLI Fahez EL ANAWI Dominique LENEN Christophe OBERLIN

Purpose of the study: Balistic nerve injury is not common in civil medicine. We analyzed a series of 30 patients who underwent surgery for this type of injury suffered in the Gaza strip between 2002 and 2004. All patients presented paralysis of the sciatic nerve or one of its major branches. All injuries were caused by war weapons.

Material and methods: The series included 28 men and two women, mean age 22 years (range 2.5–65). The injury had occurred more than one year earlier for 33% of patients. The injury was situated at the knee level in twelve patients and in the thigh in ten. Complete nerve section was observed in 12 patients and partial section in two. Loss of nervous tissue was significantly greater for lesions around the knee. Nineteen patients underwent surgery for: neurolysis (n=3), direct nerve suture (n=8) and nerve grafts (n=8). Eleven patients were reviewed at mean 13.7 months (range 3–30 months). There were no failures. Results of reinnervation of the tibial nerve territory were better than for the fibular nerve. Sixteen patients underwent palliative transfer for a hanging foot for more than six months: 15 transfers of the posterior tibial muscle through the interosseous membrane and hemitransfer of the Achilles tendon. Seven patients underwent Achilles tendon lengthening at the same time and five had a reinnervation procedure on the common fibular nerve.

Results: Seven patients were reviewed with a mean follow-up of 1.8 years (range 4–30 months. None of the patients used an anti-equin orthesis. There were three cases of forefoot malposition. The overall Stanmore score was good at 75.4/100 (range 59–100).

Discussion: High-energy ballistic trauma creates a specific type of injury. Nervous surgery can be indication early to favor spontaneous recovery. Palliative surgery for fibular lesions provides regularly good results.

Conclusion: Nerve injuries due to ballistic trauma should be explored surgically because of the possibility of direct nerve repair. In addition, depending on the type of paralysis, reliable palliative surgery can be proposed.


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Laurent NOVÉ-JOSSERAND Pédro COSTA Eric NOËL Gilles WALCH

Purpose of the study: When repairing rotator cuff tears, injury to the infraspinatus is generally a posterior extension of a supraspinatus tear. The description of isolated tears of the infraspinatus has not been to our knowledge reported in the literature. We report a series of 13 cases with more than one year follow-up.

Material and methods: Thirteen patients underwent surgery for an isolated tear of the infraspinatus between 1995 and 2004. There were ten men and three women. Mean age at surgery was 47 years (range 34–62). The right shoulder was involved in seven of the thirteen cases, and the dominant shoulder in eight. A progressive onset was observed in eleven patients and nine had a history of treated calcified tendinopathy. Clinically, pain was the predominant symptom. The Jobe test was deficient in all patients as was external rotation (except one patient). The preoperative Constant score was 70 (range 62–87). X-rays revealed type C posterior calcification in nine patients. A full-thickness tear was observed in seven cases, a partial deep tear in three, and a partial superficial tear in three. Isolated fatty degeneration of the infraspinatus noted Goutallier grade 2 or greater was observed in seven patients. Open surgical repair was preformed in all patients.

Results: Mean time to revision was 29 months (range 12–82). Subjectively, six patients were very satisfied, six were satisfied, and one was disappointed (failure by secondary tear). Two shoulder-hand syndromes were noted in the postoperative period. At last follow-up, the Constant score was 83.5 (range 64–97). All patients except one were satisfied with pain relief but the lack of force was significant.

Discussion and conclusion: Isolated tears of the infra-spinatus are rare, but there is a notable relationship with calcifying tendinopathy of the same tendon. Repair should be undertaken before the development of fatty degeneration in order to improve the chances of force recovery.


Pol BLAIMONT Albert TAHERI

Hypothesis: For Neer, humeral head ascension is caused by anterior impingement. The anatomic or ischemic factors favoring anterior impingement are well known, but have not been shown to have a determining effect. Our work on the comparative action of the rotator cuff muscles to lower the humeral head (1992), led to the conclusion that the infraspinatus muscle plays a highly dominant role. The frequent association of anterior impingement and a history of cervical pain might suggest that neurogenic paresia of the infraspinatus might be involved with the impingement effect as can be observed in intermittent paresia of the lower limbs revealing a narrow lumbar canal. Since this hypothesis was put forward, we have made converging observations in a prospective study of 200 cases.

Obervations:

When patients with anterior impingement were questioned, 80 were found to have a history of cervical pain which was confirmed radiographically and/or on computed tomography (CT).

Physical examination of the cervical spine revealed pain at pressure on the anterolateral aspect of the C4, C5, and C6 vertebrae, always homolateral to the impingement. Search for this sign has thus become part of our routine examination and, according to Maigne, confirms the vertebral origin of peripheral pain. We found it to be absent in anterior impingements caused by trauma in young subjects, and to be inconstant in traumatic anterior impingements observed in patients aged over 55 years.

After cervical arthrodesis for cervicobrachial pain, we observed five cases of progressive anterior impingement requiring decompression. In their series of 76 cervical arthrodeses for cervicobrachialgia, Hawkins et al on observed 13 cases of proven anterior impingement. They concluded there must be a relation between these two conditions.

Golg et al. provided a decisive contribution to the theory when the discovered that in anterior impingement patients, rotator cuff muscles exhibit specific histological markers of muscle denervation.

Conclusion: Most cases of degenerative anterior impingement result from atrophy of the rotator cuff muscles arising because of a cervical canal syndrome.


Pablo TURELL François SIRVEAUX Olivier ROCHE Olivier GOSSELIN Michèle DE GASPERI Daniel MOLÉ

Purpose of the study: Resection of the lateral quarter of the clavicle is an effective treatment for painful acromio-clavicular arthropathy. An open procedure can create a disgraceful or painful scar or be associated with secondary instability and muscle weakness. Arthroscopic resection would avoid these complications.

Material and methods: Between 1992 and 2002, 35 patients were treated arthroscopically for isolated painful acromioclavicular arthropathy after failure of medical treatment. Twenty-seven patients (mean age 44 years) were reviewed clinically (Constant score, subjective outcome, stability) and radiographically (quality of resection, coraco-clavicular space, ossification) at more than two years follow-up. Acromioplasty was performed in all cases to improve exposure in 14 or because of an aggressive acromion (n=7). A scarf orthesis was worn to prevent pain. Self-controlled rehabilitation exercises were proposed.

Results: There were no postoperative complications excepting one case of retractile capsulitis in the context of an occupational accident. Excluding this case, mean sick-leave was five weeks (range 3–20). At mean follow-up of seven years, all scars were pain free and minimally visible. There was no problem with frontal or sagittal instability. The Constant score improved 24 points on average compared with the preoperative score with a significant gain for pain (+9 points). Two patients were disappointed: one retained a sequellar capsulitis and one persistent pain after insufficient resection. On average, the resection measured 10 mm (range 6–20 mm). Three patients had an insufficient posterosuperior resection. The coracoclavicular interval remained unchanged in all cases and four patients presented secondary ossification of the resection zone. Two patients were sensitive to acromioclavicular palpation with a positive cross arm test (one had an insufficient resection and the other ossifications at last follow-up).

Discussion and conclusion: Arthroscopic acromio-clavicular resection reduced operative morbidity. The operation does not destabilize the joint. The total joint surface area can be resected to avoid a residual pos-terosuperior impingement which would be a source of persistent pain. The presence of secondary ossifications in the zone of resection has led us to propose NSAID treatment although the prophylactic effect remains to be demonstrated.


Dominik MEYER Hans HOPPELER Christian GERBER

Purpose of the study: Muscles contract after a full thickness tear their tendon. The muscle then undergoes atrophy and fatty degeneration. These changes produce effects well described by histology, computed tomography and magnetic resonance imaging (MRI). To date however, the correlation of this process with the future conractile force of the muscle and the prognosis after cuff repain has been poorly understood.

Material and methods: Thirteen patients with a full thickness tear of the supraspinatus muscle were treated surgically by cuff suture. The shoulders were examined clinically and MRI. During the operation, the supra-scapular nerve was stimulated with a supramaximal voltage to obtain maximal muscle contraction which was measured. Biopsy specimens of the supraspinatus were taken before and after surgical repair in order to determine whether muscle activity during stimulation have any histological impact. The intraoperative measurements were compared with the MRI findings and the physical examination performed preoperative and at six weeks, six months and twelve months after surgery.

Results: Maximal force of the supraspinatus muscle was 200N, which is greater than the force of a direct suture repair. The maximal force was clearly correlated with muscle atrophy and fatty degeneration: by surface area, force was 12N/cm2 for Goutallier grade 3 and 42 N/m2 for grade 0. Five of the thirteen repairs ended with a secondary tear, the muscle in four of the five patients was among the six strongest muscles. The fifth case was the weakest muscle of all. The histological study revealed a larger quantity of lipofuchin in the muscle with atrophy and a change in the fiber structure. Analysis of the results did not demonstrate any lesions caused by the tension during the operation. MRI demonstrated one case of repair without secondary tear, the fatty infiltration had not improved and the atrophy only partially. In muscles with secondary tears, atrophy and fatty degeneration progressed significantly.

Discussion and conclusion: There is a risk of rupture of the supraspinatus tendon in the event of muscle atrophy but also for good quality muscle. The capacity of a muscle to develop force strongly depends on the state of atrophy and fatty degeneration. Atrophy can regress after reconstruction without secondary tear, but fatty degeneration is irreversible.


Johannes BARTH Stephen S. BURKHART Dominique SARAGAGLIA

Purpose of the study: The objective of this study was to investigate a new test (the bear-hug test) in search of a more sensitive way of diagnosing small infrascapular tears. The bear-hug test was compared with other tests (lift-off, belly-press, Napoleon).

Material and methods: From January to March 2004, 68 patients were scheduled for arthroscopic shoulder surgery. We searched for correlations between the preoperative clinical results and the anatomic observations during the diagnostic phase of the arthroscopy.

Results: The prevalence of infrascapularis lesions was 29.4%. Forty percent of the infrascapularis lesions had not been identified by any of the clinical diagnostic tests. The bear-hug test was the most sensitive (60%) compared with the belly-press test (40%), the Napoleon test (25%), and the lift-off test (17.6%). The lift-off test was the most specific (specificity 100%) versus 97.9% for the Napoleon test, 97.9% for the belly-press test and 91.7% for the bear-hug test. The bear-hug test was more sensitive than the Napoleon test and the lift-off test with statistically significant difference, irrespective of the size of the tear (p< 0.05), but this difference was not found for the belly-press test (p> 0.06). Conversely, for small tears (50%), there was a statistically significant difference in favor of the bear-hug test (Se bear-hug 50%; Se belly-press 21.4%; p< 0.035). The bear-hug test was thus moe sensitive for diagnosing small tears of the upper third of the infrascapularis. A positive bear-hug or belly-press tes would suggest at least a 30% infra-scapularis tear, while a positive Napoleon test suggests at least a 50% tear. The lift-off test is only positive when 75% of the infraspinatus is injured.

Conclusion: The sensitivity of the bear-hug test optimizes chances of detecting a tear of the infrascapularis at the physical examination. Combining all of these tests is useful for predicting the size of the tear.


Nicolas BRASSART Christophe TROJANI Michel CARLES Pascal BOILEAU

Purpose of the study: The objective of this study was to identify clinical and anatomic factors which could affect the outcome of tendon healing after arthroscopic repair of rotator cuff tears.

Material and methods: This prospective cohort study included 122 patients who underwent arthroscopic treatment between May 1999 and September 2002. One hundred twelve patients (114 shoulders) were reviewed (93.4%). Mean age at surgery was 61 years. An arthroscan (78% of patients) or magnetic resonance imaging (MRI) were performed six months postoperatively. Mean follow-up was 24 months (range 13–46 months).

Results: Rotator cuff tears healed completely in 64% of the shoulders (n=73) and partially in 7% (n=8). No healing was observed in 29% (n=33). The Constant score was 49.8 preoperatively and 82.4 at last follow-up (p< 0.0001). Cuff healing improved clinical outcome with a Constant score of 85 points versus 77, particularly for force, 14.5 points versus 10 without healing. Four factors were statistically predictive of tendon healing: duration from symptom onset to operation (24 months for healed tears versus 37 months, p< 0.05); age at cuff repair (81% healed tears in patients aged less than 50 years versus 50% for patients aged over 65 years, p< 0.002); sagittal extension of the rotator interval or extension to the upper third of the infrascapularis (45% healed tears versus 79% without anterior extension, p< 0.0001); fatty degeneration (69% of healed tears for Goutallier grade 0 versus 38% for grade 1 and 2, p< 0.01).

Conclusion: This study demonstrated that four factors can predict tendon healing: time to treatment, age at surgery, anterior extension of the tear, fatty degeneration.


Guillaume HERZBERG Oliver SCHOIERER Eric BERTHONNAUD Joannès DIMNET

Purpose of the study: The appropriate treatment for massive irreparable rotator cuff tears is a subject of debate. The purpose of this work was to analyze at mean five years follow-up a series of 16 shoulders treated with a latissimus dorsi flap.

Material and methods: These 16 patients (seven women) were aged 56 years on average. The procedure was a revision for four shoulders. The tears were all posterosuperior tears and caused invalidating pain in all patients. Mean anterior elevation was 93°. External rotation was 12°. The Constant score, assessed in eleven patients, was 27 points on average. The subacromial space measured 8 mm on average. Supraspinatus fatty degeneration was grade 2 in 45% and grade 3 in 55%. Infraspinatus degeneration was grade 3 in 80% and grade 4 in 20%. The latissimus dorsi flap was associated with a teres major flap in four shoulders and with a deltoid flap in seven. The semi-sitting position was used for 15 of the 16 patients.

Discussion: Treatment of massive irreparable rotator cuff tears is a controversial issue. When the subacromial space is preserved, the presence of muscle atrophy and tendon retraction despite forced mobilization it is logical to use several muscle transfers. This small series demonstrated that a significant improvement can be obtained. Nevertheless the postoperative period is long and indications must remain limited. We discuss our results in comparison with other reported series.


Philippe VALENTI Philippe SAUZIERES Luis-Carlos DIAZ

Purpose of the study: This retrospective analysis was conducted to study the gain provided by a latissimus dorsi flap used as first-intention treatment (group 1) or secondary treatment after prior failure (group 2) for irreparable rotator cuff tears.

Material and methods: This series included ten women and nine men, mean age 58 years (range 42-64). The initial tear was a massive (> 5 cm) posterosuperior tear in 16 patients and extended to the upper third of the infra-scapularis in three. Surgery was undertaken because of persistent pain and limited joint motion despite rehabilitation. A subacromial impingement was noted in 15/20 shoulders on the arthroscan and fatty degeneration was noted as grade 3.31 on average for the supraspinatus and 3.1 for the infraspinatus (Goutallier and Bernageau classification). The latissimus dorsi flap was harvested via the superolateral approach and fixed with anchors in the superior border of the infrascapularis and on the trochiter after avivement. Tendon stumps were sutured to the medial part of the aproneurotic sheath of the latissimus dorsi.

Results: Overall outcome and outcome in group 1 patients (14 shoulders) and group 2 patients (five shoulders) were noted. Mean follow-up was 19.72 months (range 12–48). The overall Constant score progressed from 33.10 to 54.9 with a mean gain of 53° for elevation (98–151°) and 11° for external rotation (21.5–32.1°). For group 1, the Constant score progressed from 31 (15/51) to 58 (40/75) with a mean gain of 37° elevation (121–155°) and 13° external rotation (22.8–35°). For group 2, the Constant score progressed from 33 to 52 (40/75) with a mean gain of 32° elevation (88–120°) and 6° external rotation (18–24°). Pain improved from 6.3 to 11.8 on the Constant score.

Discussion and conclusion: Used as a first intention treatment for massive irreparable cuff tears with fatty degeneration scored greater than grade 3, the latissimus dorsi flap provides better results than when it is used after failure of a prior procedure. Results are good for pain relief and active elevation (45°) but modest for external rotation (6–13°) and zero for force. The two failures and the two cases of only fair subjective outcome were in group 2. We reserve the procedure for painful pseudo-paralytic shoulders in subjects aimed less than 60 years who do not respond to prolonged rehabilitation.


Elvire SERVIEN Gilles WALCH

Purpose of the study: Posterior shoulder instability is a rare condition. Several surgical treatments have been proposed.

Material and methods: This was a retrospective series of 21 posterior bone block procedures performed between 1984 and 2001 and analyzed with mean follow-up of six years. Fifteen patients (n=16) had experienced one or more episodes of posterior dislocation. Thirteen patients were athletes and five had traumatic subluxation with chronic posterior instability. Voluntary recurrent dislocations were not observed in these patients. Male gender predominated (n=19 men, 1 woman). Mean age at surgery was 24.8 years (range 17–40). The dominant side was involved in 12 patients (57%). The Constant and Duplay scores were noted as were the pre- and postoperative x-ray findings. There were ten glenoid fractures, two glenoid impactions, ten anterior humeral notches. Mean retroversion, measured on the scans (n=17) was 9.6° (range 0–21°).

Results: All patients (n=20) were satisfied or very satisfied. At last follow-up, the mean Constant score was 93.3 (range 80–103) and the mean Duplay score (n=21) 85.6 (40–100); 68.2% of patients (n=15) resumed sports activities at the same level. Failure was noted in three patients, one with recurrent posterior dislocation and two with major apprehension. For two patients, glenohumeral osteoarthritis developed postoperatively.

Discussion: Most of the series in the literature have reported results for patients with recurrent posterior subluxations and not for traumatic posterior dislocation, the much more uncommon entity presented here. The rate of bony lesions was high in our series compared with former series in the literature. These results can be explained by two facts. The first that this was a group of recurrent posterior dislocations and second that the analysis of the osteoarticular lesions was made on plain x-rays and/or CT scans. For the two cases of glenohumeral osteoarthritis which developed postoperatively, the position of the bone block does not appear to be involved.

Conclusion: The posterior bone block remains the treatment of choice for recurrent posterior dislocation. The risk of developing osteoarthritis appears to be low but a longer follow-up would be necessary for confirmation.


Laurent NOVÉ-JOSSERAND Pédro COSTA Jean-Pierre LIOTARD Eric NOËL Gilles WALCH

Purpose of the study: Latissimus dorsi transfer is proposed for irreparable superior and posterior rotator cuff tears, particularly in the effect of deficient active external rotation. The purpose of this study was to analyzed outcome at minimum two years follow-up.

Material and methods: Between 2001 and 2002, eleven patients underwent latissimus dorsi transfer for an irreparable tear of the supraspinatus and infraspinatus. Surgery was proposed because of the patient’s young age and occupational activity level, or because of a disabling deficit of active external rotation. There were six men and five women, mean age 52.5 years (range 36–66 years). There were seven right shoulders and nine dominant shoulders. Symptom onset was progressive in seven with a mean duration of 33 months (range 2–144 months). Active external rotation was measured at −14° to 29° in five patients with a positive dropping test. Three patients presented pseudoparalysis. The preoperative Constant score was 52±12 points. Preoperative the subacromial space measured less than 6 mm in all patients. Muscle degeneration of the infraspinatus was noted grade 2 or greater (Goutallier).

Results: Mean follow-up was 26 months (range 24–36). Subjective outcome was very satisfactory for eight patients, satisfactory for one and disappointing for two. Seven of nine patients resumed their occupational activity. The postoperative Constant score was 73±10 points. None of the patients presented pseudoparalysis at review. Pain was improved in all. Active external rotation was significantly improved in six. Postoperative, the dropping test persisted in two patients. The subacromial space was still 6 mm. Better results were obtained when active deficit was predominant than when anterior elevation (pseudoparalytic shoulder) or external rotation (positive dropping test) were predominant.

Discussion and conclusion: Latissimus dorsi transfer provides a solution for irreparable superior and posterior rotator cuff tears. The pain relief is significant. Active external rotation is improved. This is an interesting alternative in young patients or when the motor deficit is a severe handicap.


Pierre MANSAT Paul BONNEVIALLE Yves BELLUMORE Anne BROUCHET-GOMEZ Denis CLÉMENT Michel MANSAT

Purpose of the study: The proximal humerus is a common localization for solitary endchondroma. Levy (Clin Orthop2004, 431) emphasized the frequency of associated muscle and tendon disease. Treatment is generally curettage-autograft filling. Use of calcium phosphate bone substitute has been validated (A. Uchida et al. J Bone Joint Surg (Br) 90, F. Gouin Rev Chir Orthop 95, R. Mirzayan J Bone Joint Surg (Am) 2001). This retrospective analysis was conducted to determine the signs and symptoms and report the results of surgical treatment obtained in a consecutive series of 15 patients with metaphyseal enchondroma treated in the same unit.

Material and methods: This series included twelve women and three men, mean age 48.2 years (range 38–73). All complained of pain. Two also had signs of calcification and six presented a cuff tendinopathy. Eight had had one or more joint injections. On average, the enchondromas measured 3.1 cm on the ap view and 3.6 cm on the lateral view. Magnetic resonance imaging (MRI) demonstrated the presence of a subacromial effusion in 13/16 shoulders, supraspinatus tendinopathy in six, calcifications in three, and acromioclavicular arthropathy in three. Curettage was followed by filling with biphased tricalcium phosphate (SBM, Lourdes) associated in nine shoulders with acromioplasty-bursectomy and in two with resection of a calcification.

Results: There were no postoperative complications. Mean follow-up was six months. All patients recovered joint motion, seven were pain free, six complained of pain at exercise and two had episodic pain. There were no local signs of substitute intolerance. Follow-up was greater than one year in 12 patients and greater than two years in eight: seven shoulders were pain free, three presented pain at exercise, and two required analgesic drugs. Radiographically, the limit between the bone substitute and the cancellous bone was imprecise; the bone substitute could not be readily visualized in four shoulders, had faded out in three, and was visible in five.

Discussion: The association of enchondroma and a rotator cuff pathology is common suggesting the tumor could affect disease expression. Imaging provides strong arguments favoring a benign disease. Use of bone substitute for filling is reliable and avoids the need for an iliac graft.

Conclusion: A fortuitously discovered or painful enchondroma of the humerus should be treated by curettage-filling with bone substitute as soon as the nature of the tumor has been clearly identified and/or strong uptake on scintigraphy visualized. This is a supplementary operative argument suggesting an associated cuff pathology.


M K Sayana C Wynn-Jones

Introduction: Elective Orthopaedics has been targeted by the department of health in the U.K. as a maximum six-month waiting time for operations could not be met. National Orthopaedic project was initiated as a consequence and Independent Sector Treatment Centres (ISTC) and well established private hospitals were utilised to treat NHS long wait patients.

Materials and Methods: We audited the primary total hip replacements performed in our hospital in 1998 and 2003 to compare the differences in the patient characteristics in particular age, length of stay and ASA grade.

Results: The number of hip replacements increased to 308 in year 2003 from 194 in year 1998. Whilst, the number of ASA I patients were the same, the ASA II. III, IV increased by 40%, 260%, 266% respectively. The average length of stay decreased from 14.3 to 11.9 days which was statistically significant, in spite of increased numbers of ASA II – IV patients.

Discussion: The NHS hospitals are treating increasing number of patients who have a higher anaesthetic risk and are likely to stay longer in the hospital in the post-operative period. The case mix for primary total hip replacements in large tertiary referral hospitals have changed due to altered patient flow due to cherry picking of NHS waiting lists by the ISTC. NHS hospitals should be appropriately remunerated for dealing with complex cases and for managing complications referred by ISTC hospitals. In fact, the National joint registry’s 2nd annual report confirms that 40% of primary total hip replacements operated in ISTC’s were ASA I while only 25% of primary total hip replacements operated in NHS hospitals were ASA I. None of the ISTC’s performed complex primary THRs.


A Shah S Alshryda A Hegab J Doyle T Brewood B Ilango R McGivney

Background: Several hospitals within the NHS now run specialist teams that look after assisted discharge plans for patients following elective surgeries. Joint replacements form a significant segment of elective majors in orthopaedics. In the second half of the last year alone, the National Joint Registry estimated that there were over 100,000 joint replacements carried out within England and Wales. Such schemes are designed to: 1. Enable patients to be discharged to their home as quickly and safely as possible, to maximise recovery and rehabilitation. 2. Ensure the most effective use of acute orthopaedic beds. 3. Reduce risks of hospital acquired infection 4. Streamline inpatient care so as to positively impact upon inpatient and outpatient waiting times. There is scarce information available about the experience of NHS hospitals with such schemes.

Aims And Objectives: 1. Investigate patient expectations of and satisfaction with discharge planning on the early discharge scheme. 2. Assess areas of concern to the patient and difficulties encountered by the patient in the home environment. 3. Improve our understanding of patient requirements, functional recovery and planning of discharge. 4. Investigate whether our lengths of stay compare with others in the NHS/literature and what factors are influencing the figures. 5. Investigate overall success of the scheme.

Patient And Methods: The study identified 100 consecutive patients who have had joint replacement surgery after August 2003 and have been discharged under the scheme. A Patient Satisfaction Questionnaire was used and the patients completed different sections at discharge and then at about six. Notes were reviewed for any complications or problems.

Conclusions: The scheme to discharge patients early is highly successful and well received by staff and patients. All consultants now use the service and the initial aims have been met, saving approximately 335 bed days in the first six months. The average inpatient stay has been reduced by half in the last 18 months. 98% of patients stated that the scheme met their needs. The majority of comments were positive. Only two patients needed readmission within the first fortnight from discharge, one with a dislocated hip and the other was a knee with wound infection. There were two complaints, which were deemed serious enough for a mention.


VD Shetty SL Vowler RN Villar

Introduction: Although there are a number of publications in the literature on managing post-operative pain and early rehabilitation after surgery in general, there has been little work on the influence of anaesthetic technique on the post-operative length of hospital stay following primary total hip replacement (THR). We wished to particularly study the influence of anaesthetic technique and the anaesthetist concerned on the length of hospital stay, as well as the effect of age and body mass index (BMI).

Methods: We studied 121 consecutive THRs in 109 patients. All procedures were performed by the same surgeon using the same posterolateral approach, prosthetic design and the same physiotherapy protocol. Patients received either general anaesthesia alone (50 THRs) or a combination of general and local anaesthesia (lumbar plexus block; 71 THRs) from three separate anaesthetists. The influence of anaesthetist, anaesthetic technique, age, and BMI on length of stay after primary THR was assessed separately.

Results: Our analysis showed that the length of hospital stay was greatly influenced by the anaesthetic technique used (p < 0.0001), those patients who received a lumbar plexus block having a shorter median length of hospital stay (3 days) than those who received general anaesthesia alone (5 days). The age of the patient was also critical (p = 0.003) as was the anaesthetist concerned (p = 0.01). BMI was unimportant.

Discussion: For those surgeons who believe that a reduction in the length of hospital stay after primary THR is a worthwhile objective, we have one over-riding observation – the anaesthetic technique used, and the anaesthetist involved, are critical.


H A P Archbold B Mockford D Molloy J McConway L Ogonda D Beverland

Introduction: A critical determinant of early dislocation following total hip arthroplasty (THA) is correct positioning of the acetabular component. This challenging aspect of THA has not been lessened by the introduction of more minimally invasive techniques. In this paper we introduce a simple and reproducible technique, which uses the transverse acetabular ligament (TAL) to determine cup orientation. We have used this technique as the sole method of cup orientation in our last 1000 consecutive primary total hips.

Methods: One thousand consecutive patients were studied in order to determine the prevalence of early dislocation (within 3 months) following acetabular component placement determined by reference to the transverse ace-tabular ligament. All patients underwent primary total hip arthroplasty via a posterolateral approach with a posterior repair.

Results: At a minimum follow-up of 9 months (range 9–39 months) 6 of the 1000 hips (0.6%) had dislocated.

Conclusion: Although multiple factors are known to contribute to this rate correct placement of the acetabular component is critical. As our results compare favourably with other published series where a posterior repair has been performed by extrapolation we feel that that the TAL does provide an acceptable method of determining cup orientation. The fact that it is independent of patient position on the table and is easy to locate with a minimally invasive approach makes it an attractive method.


G J Shah O Ghazanfar S Shah G C Singer

Introduction: Serum inflammatory markers are routinely used as pre assessment investigation before the revision hip surgery. Various investigations are used to aid in diagnosis of infection in the revision prosthetic hip replacement including aspiration, broad range PCR, bone scan and serum interleukin- 6.

Materials and Methods: 256 consecutive revision total hip replacements were assessed for the value of pre operative ESR and c-reactive proteins (CRP) in predicting the deep infections.

All patients were evaluated prior to surgery. The patients with coexisting inflammatory disease or peri-prosthetic fracture were also evaluated.

A hip was diagnosed as infected on the basis of positive intra operative microbiology samples three or more out of five and or histological evidence.

Results: Using the values of ESR > 35 mm/1st hour and CRP> 10mg/l, the positive predictive value (either /or) was 56% and the negative predictive value was 96%. 14 patients had an underlying inflammatory arthritis and 5 were peri prosthetic fractures. The inflammatory markers tended to be elevated in these patients. Excluding these 19 patients and using the same criteria, the positive predictive value was 65% and the negative predictive value was 97%

Discussion: We conclude that a CRP< 10 mg/l and ESR < 35 mm/1st hour are very useful in excluding infection (negative predictive value of 97%, excluding peri-prosthetic fractures and inflammatory joint disease), but raised inflammatory markers are less accurate in predicting infection.


PB Young P Bobak EJ Gray TN Board EB Austin PR Kay

Introduction: The long term success of impaction grafting depends on the remodelling process during incorporation. This project was devised to characterise any differences in the biochemical markers of bone turnover following revision hip arthroplasty performed with or without impaction grafting.

Methods: 87 patients were entered into this prospective study and grouped according to whether impaction allograft was used or not. Biochemical markers of bone turnover were assessed pre-operatively and post-operatively on day 2, day 9, week 6, 6 months and 1 year. Osteocalcin, procollagen type-I N-terminal propeptide and bone specific alkaline phosphatase were measured as bone formation markers. C-telopeptide, pyridinoline and deoxypyridinoline were measured as bone resorption markers.

Results: All patients had a successful outcome at one year. 50 patients with radiologically defined host-graft union were compared with 37 patients who did not receive an allograft. Markers of bone formation tended to rise by day 9 but the rise in osteocalcin was delayed in the graft group and was significantly lower at 6 months in comparison to the non-graft group (p=0.002). Alkaline phosphatase levels remained significantly elevated at one year in the graft group (p=0.027) whilst levels in the non-graft group had normalised. Markers of bone resorption also rise in both groups but with no significant differences between the groups.

Discussion: Following impaction grafting, new bone formation may be delayed in comparison to revisions performed without graft. The pattern of markers of bone resorption did not differ significantly between the groups suggesting that there is no large scale resorption of the impacted allograft in these cases.

These results provide a biochemical insight into the bone formation and bone resorption processes during allograft incorporation.


B Ollivere K Logan N Ellahee P Allen

Introduction: Infection remains the single most important complication in elective joint replacement. 1.1% of patients suffer early deep infection and 10–17% of patients superficial infection [1]. Antibiotic prophylaxis has been used extensively in elective orthopaedic practice, approximately halving the post-operative infection rate [2]. Cefuroxime is almost universally used in the UK. However there is an increased incidence of multiple drug resistant bacteria within the environment in addition cephalosporin use and resistance is widespread [3]. Many patients are treated pre-operatively for urinary tract infections with cephalosporins, and a further group of patients are already colonised with cephalosporin resistant staphylococcus. We have previously shown that 8.1% of patients fall into one or other of these categories.

Methods: We present a prospective series of 630 serial elective orthopaedic admissions from all orthopaedic disciplines. We have examined notes and reviewed lab records in order to determine outcomes. The centre for disease control [4] definition was used for suspected infections, and confirmed with wound swabs. 48 cases were confirmed infectious from a suspected 142 cases meeting this definition.

Results: We found a positive correlation between previous urine infection, MRSA status, revision surgery, and diabetes and wound infection. Nearly 35% of bacterium cultured were cephalosporin resistant, and 12% demonstrated multiple antibiotic resistance.

Discussion: It is good clinical practice to provide antibiotic prophylaxis in joint replacement, but the blind use of cephalosporins in all patients does not make sense because of increased incidence of antibiotic resistant bacteria. We present evidence based guidelines for the use of antibiotic prophylaxis in elective orthopaedic surgery and empirical antibiotic treatment in patients with wound infection before culture results are available.


C Chadwick H K Parsons P Norman R M Kerry

Introduction: Deep infection is a devastating complication following hip arthroplasty. In the early 1970’s Staphylococcus Aureus (SA) was believed to be the causative organism in most cases and Coagulase Negative Staphylococccus (CNS) was widely regarded as a contaminant. It subsequently became recognised that the majority of infections are caused by CNS rather than SA, probably due to the use of peri-operative antimicrobial agents and laminar air flow in theatre.

Aims: The aim of this study was to look at the causative organisms in patients with an infected total hip replacement to see if the pattern of infection has changed with time.

Methods: Between February 1999 and November 2004, 95 patients underwent 1st stage revision surgery at the Northern General Hospital for definite infection following total hip replacement. At least 5 tissue samples were taken at the time of surgery prior to antibiotic administration. Infection was confirmed when at least 3 of the samples were positive on microbiological culture. We retrospectively reviewed the records of these patients and identified the causative organisms.

Results: The 95 patients were infected with 130 different organisms. Of these 32% were SA including MRSA (7.2%), 27% CNS, 13.6% Enterococcus, 4.8% pseudomonas and 3.2% Streptococcci. 29% of patients had polymicrobial infection.

Discussion: Data published in the literature as well as historical data from our unit suggest that CNS is by far the most common organism causing prosthetic hip joint infection. Our results however, show a recent decrease in the proportion of CNS and an increase in SA and polymicrobial infection.


SM Blake MJ Hubble JR Howell AJ Timperley GA Gie

Introduction: Removal of all foreign material is the normal practice at the time of revision arthroplasty for sepsis. However, removal of well fixed bone cement is time consuming, can result in significant bone stock loss and increases the risk of femoral shaft perforation or fracture. We report our results of 2 stage revision hip arthroplasty with retention of a well fixed femoral cement mantle.

Methods: If the femoral cement mantle demonstrated good osseo-integration at first stage it was left in-situ. Following Girdlestone excision arthroplasty (GEA), patients received local and systemic antibiotics and underwent reconstruction at a second stage. At the second stage the femoral component was cemented into the old mantle.

Results: 16 patients (M:F 5:11) had at least 3 years follow up (mean 80 months, range 43 to 91). 1 patient died of an unrelated cause at 53 months. Recurrence of infection was not suspected in this case. The mean time to first stage revision was 57 months (3 to 155). The mean time between first and second stages was 9 months (1 to 35). Organisms were identified in 14 (87.5%) cases (5 Staphylococcus Aureus, 4 Group-B Streptococcus, 2 Coagulase negative Staphylococcus, 2 Enterococcus Faecalis, 1 Escheria Coli). At second stage 5 (31.2%) acetabula were uncemented and 11 (68.8%) were cemented. There were 2 complications, 1 patient dislocated 41 days post-operatively and a second patient required an acetabular revision at 44 days for sudden loss of fixation. No evidence of infection was found at re-revision. Currently no patients are suspected of having a recurrence of infection.

Discussion: In-cement revision of the femoral component following GEA for sepsis is not associated with a higher rate of recurrence of infection. Advantages include a shorter operating time, reduced loss of bone stock, improved component fixation and a technically easier second stage procedure.


SJ Phillips R Chavan ML Porter P Kay Hodgkinson B Purbach A Hoad Reddick JM Frayne

Introduction: We performed a retrospective case control study in 80 patients who under went revision hip surgery at our unit.

Methodology: Group A (40 patients), received tranexamic acid and intra-operative cell salvage. Group B (40 patients) a matched control did not receive these treatments. Each group was divided into 4 sub groups; revision of both components, revision of components + bone grafting, revision acetabular component +/− bone grafting and revision femoral component +/− bone graft.

Results: In group A the total number of units transfused was 139 compared to 52 in group B. This represents a reduction in blood usage of 37%. The mean amount of blood transfused from cell salvage in each group was 858mls, 477mls, 228mls and 464mls. There was a significant difference in the amount of blood returned between the groups (p< 0.0001). In the control group 37 patients needed transfusion, in the study group 22 (p< 0.0001). At our unit a cost analysis calculation has shown total revenue saving of £88,000 and a potential saving throughout the trust of £316,688 per year.

Discussion: To our knowledge this is the first study to examine the use of cell salvage and tranexamic acid in revision hip surgery. Our results show that a significant reduction in blood transfusion can be made using this technique. It is vital that blood conserving strategies are developed so that future revision surgery can continue.


K M Venu SR Samsani D Nunn

Introduction: Several techniques have been described for revision of acetabulum associated with severe superior bony defects. An Oblong cup inserted without bone cement has the advantage of restoration of the centre of hip rotation and maintenance of bone stock. The aim of this study was to analyse the medium-term results of acetabular revision using Oblong cup for severe superior bony defects.

Methods: Thirty-five acetabular revisions using porous coated Oblong cups (S-Rom, Depuy) in 34 patients were performed by the senior author between 1998–2001. All patients were followed-up clinically and thirty-one hips were analysed radiologically for a mean duration of 39.6 months (range 18 to 60). The clinical assessment was performed using Harris hip score and subjective patient’s satisfaction. The acetabular defects were classified according to the method described by Paprosky et al. The position of the acetabular implant, restoration of the centre of hip rotation and the extent of osseo-integration of the acetabular shell were assessed in the post-operative radiographs.

Results: The mean Harris hip score has improved from a preoperative value of 40.6 to 69.4 post-operatively. According to the Leprosy’s method, two acetabula were classified as type 2B, 12 as type 3A and 17 as 3B. The post-operative radiographs showed a mean abduction angle of the Oblong cups of 54.2 degrees (range 40–80). Osseointegration was achieved in 29(94%) of cups. Three cups showed early migration, of which two eventually stabilised and osseointegrated by 12 months. The centre of rotation of hip improved from a mean lateral migration of 8.3 mm and superior migration of 23.5 mm in the pre-operative radiographs to 2.8 mm and 4.3 mm respectively post-operatively.

Discussion: Acetabular revision using porous coated oblong cup for severe superior acetabular defects provides satisfactory medium-term results with predictable restoration of hip centre of rotation.


M El-Deen S Zahid D Miller A Nargol R Logishetty

Introduction: Revision total hip replacement has high rates of failure which appears to be due, in part, to deficient bone stock that does not provide an adequate environment for fixation of the implant. Cementless modular implant offers the possibility of restoration of bone stock in conjunction with adequate fixation, thus re-establishing the function of the hip without the use of additional cement. This study reviews patients treated with the S-ROM system, assessing clinical outcomes, implant stability and osseous response to the hip revisions.

Methods: Sixty two cementless revision hip arthroplasties were performed using the S-ROM prosthesis between 1996 and 2001. Fifty four were available for follow up evaluation at 3 to 8 years (median 4.5 years). Radiological analysis, patient satisfaction and Harris hip scores were assessed pre and post operatively then at average of 4.5 years later.

Results: Eighty-five percent of patients were satisfied with the result of surgery. Clinical scores improved from a preoperative value 34 to 80 points post-operatively and were maintained on further assessment at average of 4.5 years. Forty-three stems had solid bony ingrowth, nine had mild subsidence initially averaged 6.4 mm then stabilized. Two had marked initial subsidence, which also later stabilised. There was gradual filling of the osteolytic defects in 32 of the 37 (86.5%) femoral lesions.

Discussion: With improvement of the postoperative hip score by more than 50 points and absence of definite implant instability at the final follow up, the results of use of S-ROM prosthesis in the revision cases of this study seems to be successful. The follow up is relatively short, but the experience derived from this work confirms the versatility of the S-ROM prosthesis in the complex hip revision situations as well as its favourable mechanical and biologic impact on the adjacent osseous structures.


S A Jones L Lougher A John M Maheson

Introduction: We report our experience with the ZMR Hip System (Zimmer Inc.). The system accommodates a number of femoral fixation philosophies including spline, porous and taper stem options. The tapered stem is designed to achieve a distal wedge fit and also allow bone on-growth via the corundumized titanium alloy surface. The modular mid-stem junction allows a selection of body designs to be selected providing significant intra-operative flexibility and version adjustment.

Method: This study considers 64 cases performed in 63 patients with a mean age at the time of surgery of 70 years (range 55–89) utilising the taper stem design. The indication for revision surgery was aseptic loosening in 33 patients (Paprosky types II – 12, IIIA-10, IIIB-11) 22 peri-prosthetic fractures (Vancouver types B2-15, B3-7), 8 for infection and 4 patients with instability.

Results: The cohort had a minimum three-year follow-up with a mean of 50 months (range 36–72) and clinical assessment included Oxford score and thigh pain assessment. Engh’s criteria was utilised in the radiological evaluation when considering femoral component fixation. Femoral stem subsidence and femoral bone stock were also appraised on serial follow-up radiographs.

Discussion: The survival rate at follow-up with stem revision being the end point was 100%. When re-operation for any reason and radiological loosing are considered as the end point the survival rate was 95%.

Conclusion: We conclude excellent medium term results with the use of a cementless modular taper stem in challenging femoral revision surgery.


R L Carter R M D Meek P Grigoris

Introduction: This study is a prospective series using a porous-coated cobalt-chromium alloy cup augmented with screw fixation for acetabular revisions.

Methods: Between August 1997 and December 2001, eighty-five consecutive cementless acetabular revisions (81 patients) were performed. The mean age at operation was 64 years. Using the AAOS classification of acetabular defects there was one type I defect, 25 type two defects and 59 type III defects. Eighty-three cases were available for review (98%) with an average follow up of 6 years 6 months (range 3 months – 110 months). Clinical outcome was measured using the Charnley Hip Score and radiological assessment by plain radiographic measurement.

Results: The Charnley Hip Score had improved from a pre-operative average of 7.52 (range 4–11) to the latest score of 14.84 (range 8 – 18). Significant cup migration occurred in only one case, which did not require revision. Sixteen cases demonstrated non-progressive radiolucent lines in one or two Delee and Charnley zones but none extended to all three zones. There were no cases of significant osteolysis. There were five dislocations none requiring re-operation; one revision was carried out for deep infection and one liner exchange at time of stem revision for subsidence. The results of Kaplan-Meier survival analysis using revision for all causes as the endpoint was 98.8% (95% confidence limits 0.964 to 1) at seventy-three months.

Discussion: This press fit porous-coated cobalt-chromium alloy cup augmented with screw fixation for acetabular revision surgery produced excellent midterm results. Changes in cup design and material should only be undertaken with consideration of such results.


Sn Anjum Pg Sherry

Abstract: resurfacing hip arthroplasty has shown promising early results in the treatment of hip arthrosis in younger patients as published from specialist centres in the United Kingdom. We are reporting early results and complications of Birmingham hip resurfacing arthroplasty (BHR) from a district general hospital.

This is a retrospective study of 216 hips in 186 patients during January 1999 to December 2004. The study included review of notes and X rays and a questionnaire based assessment of hip function and activities using Oxford Hip Score (OHS) and Duke’s activity score (DAS). This study has got national ethical committee approval.

The response rate for questionnaire was 76%. Average age was 53.3 years (range 20–72). Male: female ratio was 3:1. There were 152 unilateral and 32 bilateral cases. Majority of the cases had osteoarthritis in the hip. Average follow-up was 30.3 months (range 12–72). Average length of stay was 6 days (range 3–17). Average OHS and DAS were 15.8 and 51 respectively. 163 patients had OHS of less than 24. 113 patients had DAS of 58.2.

Radiological assessment showed six cases of hetero-topic calcification. Lysis was noted at prosthesis-neck junction in two cases but patients were asymptomatic.

The complications included superficial wound infection in 2, DVT in 6, neuroparaxia of sciatic and brachial plexus in one case each. There were six dislocations. There were nine revisions – seven following fracture neck of femur and two for aseptic loosening. The incidence of fracture neck of the femur was high in early part of the study suggesting technical improvement with experience.

Overall failure was 4.1%, slightly higher than other published literature. The OHS and DAS were comparable to other published results.

In conclusion the results of the BHR are encouraging and long-term prospective study is needed to find out the longevity of the implants and long-term results.


TCB Pollard RP Baker A Dickie SJ Eastaugh-Waring

Introduction: The results of metal-on-metal hip resurfacing (MOMHR) from inventing centres show excellent function with low revision rates in the short to intermediate term. This study investigated whether similar results could be achieved in an independent unit.

Methods: All cases of MOMHR were identified since its introduction in our centre in 1999, and cases with less than 18 months follow-up excluded. Outcome was assessed by Oxford Hip Score (OHS), and UCLA activity score. Complications and further surgery was recorded. Pre-, post-op and follow-up radiographs were reviewed.

Results: 358 resurfacings in 315 patients (238 Birmingham hip resurfacings and 120 Cormet 2000, 8 surgeons). 13 (3.6%) revisions: 4 early fractures, 6 osteonecrosis, 1 aseptic femoral loosening, 1 infection, 1 isolated cup revision. 2 died, 16 (4.7%) were lost to follow-up. Outcome was assessed in the remaining 327 hips at a mean 39 months (18–79). Median OHS 13, median UCLA score 8. 89% employed in moderately heavy or heavy occupational work pre-operatively were similarly employed at follow-up.

2 cups had migrated and 6 had lucent lines. 8 femoral components had migrated. 6 had focal osteolysis. 66% of hips had ‘pedestal’ signs around the stem of the femoral component (classification proposed).

Discussion: The functional outcomes achieved in this series match those from inventing centres, but the revision rate was higher. This is partly explained by early fractures which may be associated with poor case selection or technical errors early in a surgeon’s learning curve. Later failures, of which osteonecrosis is of particular interest, also occurred at a higher rate. Migration of the femoral component may represent impending failure and further work is required to define the aetiology and consequences of the pedestal signs noted.


M Khan JH Kuiper E Robinson L Macdonald A Bhoslae JB Richardson

Introduction: The Trent arthroplasty register reported that results of Hip arthroplasty in general setup were less than that reported from specialist centres by 5%. This independent prospective study tests the hypothesis that results of Birmingham Hip Resurfacing arthroplasty from specialist centres would not accurately represent the outcome of hip resurfacing when performed in general setup.

Material and Methods: All patients were prospectively followed for at least five years at Oswestry Hip outcome centre. The surgeons carrying out the operation prospectively provided surgical details and thereafter patients were followed using Oswestry hip questionnaire (OSHIP) at fixed intervals. Survival was assessed by Kaplan-Meier method. The results were compared to the published results of BHR from specialist centers

Results: There were 679 patients, and 58 surgeons in the study. Mean age at operation was 51 years and mean follow up was 5.63 years. The predominant preoperative diagnosis was osteoarthritis. The mean OSHIP score was 89.5. There were 29 (4.2%) failures mostly due to fracture neck of femur (62%); all of them were revised to conventional THR. The Kaplan-Meier survival at seven years is 95.354%.

Discussion: Compared to the published results, there were 2 to 19 times high failure rate which is significantly higher (p=0.001) than the published studies. Hence we prove our hypothesis, as the results of BHR from specialist centres do not accurately reflect on the outcome in general setup. The discrepancy in the results that we have identified would help to identify the weak areas in the general setup, where most of the patients get benefited from BHR arthroplasty.


J Daniel C Pradhan H Ziaee PB Pynsent DJW McMinn

Introduction: Hip resurfacing is a bone conserving option that offers a better revision prospect for young and active patients. Encouraging results from several centres prove that they function well in the early years. Their long-term survival will be known from continued monitoring of early resurfacings.

Methods: This is a retrospective study of two cohorts of young (< 55 years) patients of osteoarthritis treated with hybrid-fixed metal-metal resurfacings. The cohorts are a) consecutive patients treated by the senior author in 1994 and 95 with a hydroxyapatite-coated smooth uncemented cup and a cemented femoral component and b) consecutive patients treated with hydroxyapatite-coated porous uncemented cup and a cemented femoral component since 1997 with a minimum follow-up of 5 years. 420 resurfacings (360 patients, 287 males and 73 females) were reviewed with Oxford hip scores and activity level monitoring (UCLA scale). Mean age at operation was 48.3 years.

Results: Ten patients (11 hips) died from unrelated causes. Out of the remaining 409 hips (350 patients) at a follow-up of 5 to 11.5 years (mean 7.1 years), there was one failure (cumulative failure rate 0.25% at 11 years) from avascular necrosis of the femoral head. The mean Oxford score of the 350 patients is 13.4. 87% had a UCLA score of 7 and above. 55% participated in impact sports or were involved in heavy occupational work.

Discussion: In the present study, with no loss to follow-up, excellent hip survival (99.75%) and activity level were seen. Young patients regard return to activities as one of their highest priorities. None of these patients were advised to change their activities at work or leisure.

The extremely low failure rate in the medium term proves the suitability of resurfacing in young active patients. However, caution needs to be exercised until long term results are available.


H Ziaee J Daniel C Pradhan DJW McMinn

Introduction. The usage of metal-metal bearings in young patients has rekindled the debate about the potential adverse effects of mutagenecity on offspring born to them. This question could be answered in part if it was known whether metal ions are transferred to the developing foetus. One recent study seems to suggest that such transfer does not occur [Brodner et al, J Arthroplasty2004; 19 Suppl(3) p102–107]. Unfortunately the instrument used there was not sensitive enough (5 out of 6 analyses were below the limit of detection), leaving the question of transplacental metal ion transfer unanswered. The present study uses a more powerful analytic technique.

Methods. After informed consent, whole blood specimens were obtained at the time of delivery from five patients who had undergone a Birmingham Hip Resurfacing and from their babies’ umbilical cords. High resolution plasma mass spectrometry (HRICPMS) was used for analysis.

Results. Cobalt and chromium ions have been detected in all the specimens obtained so far. The cord blood cobalt levels were lower than the mothers blood levels in all the specimens. A similar relationship was found in all but one individual chromium measurement. The mean (±95% CI) of the two groups are shown in figure 1.

Discussion and Conclusion. The present study shows that with the use of whole blood specimens rather than serum; and the use of a better analytic method than previously used in the only other study on the topic, metal ions can be detected in all specimens of patients with metal-metal devices and in the cord blood of babies born to them.

There is sufficient evidence in this study to prove that metal ions do cross the placenta. There is therefore a continuing need for vigilance on the possible effects on the offspring born to patients with metal-metal devices.


S Sharma U Vassan Ms Bhamra

Introduction: Peri-prosthetic osteolysis due to wear has been acknowledged as a major challenge to long-term survival of hip arthroplasty and this has led to a search for alternative articular bearing couples. We present our experience with metal-on-metal (Metasul®) articulation with a minimum patient follow-up of 5 years.

Materials and methods: 193 patients (215 hips) were reviewed; 187 (209 hips) had a follow-up of ≥ 5 years. Hip scores were completed and radiographs performed at follow-up visits and data was entered prospectively into software (orthocom) designed by Sulzer Ltd.. Serial radiographs were reviewed retrospectively along with hospital notes and the database.

Results: mean age was 70 (± 7.46) years (range 47–86 years). Female: male was 143:44. Most common pre-operative diagnoses were: osteoarthritis (147) and intra-capsular hip fracture (22).

Mean pre-operative HHS was 39.7 (±15.7) and the corresponding pain score was 13.4 (±8.49). The average post-operative scores were 89.5, 87.3, 88.4 and 85.8 at 1 year, 3 years, 5 years and final follow-up respectively. The corresponding pain scores were 42.7, 41.98, 42.1 and 41.94. Implant survival for the cohort as a whole was 95.5% at 12 years (ci: 88%–100%). Survivorship for the Weber Metasul cup was 93.4% at 12 years (ci: 82.7%–100%) and for armor cup was 100% at 11 years.

Complications included: dislocations (7), periprosthetic fractures (8), deep infection- early (3) & late (3), aseptic loosening (cup) (2) & heterotopic ossification (9). There were no untoward systemic complications with regards to metal ion release.

Discussion: We believe that second generation metal-on-metal implants (Metasul®) with improved design and better lubrication show better survival with regards to aseptic loosening and reduction in osteolysis in the medium-term. Concerns regarding metal ion and metal particle release remain theoretical but are kept under constant review.


SJ Spencer R Carter H Murray RMD Meek PG Grigoris

Introduction: Hip resurfacing is a popular alternative to total hip arthroplasty. It aims to provide more physiological loading of the proximal femur, avoiding stress shielding and associated bone resorption. However, finite element analysis of hip resurfacing systems suggests stress shielding occurs in the femoral neck below the prosthesis and theoretically may lead to femoral neck fracture. Nevertheless, recent DEXA studies indicate femoral bone stock preservation with no evidence of stress shielding. It is not yet known what actually occurs in clinical practice. The aim of this study was to assess whether femoral neck resorption occurs in one particular type of hip resurfacing post operatively and quantify the degree of narrowing.

Methods: Femoral neck resorption of the Cormet 2000 metal-on-metal resurfacing prosthesis (Corin, UK) was assessed by measuring the prosthesis-neck ratio on postoperative radiographs. 39 prostheses (35 patients) were measured on plain AP pelvis radiographs taken immediately and mean 2 years post-operatively. Subsequent follow up radiographs were measured up to maximum 7 years follow up, mean 4.75 years.

Results: There was evidence of neck atrophy in 35/39 hips at an average of 2 years post operation, with the overall average neck narrowing from a ratio of 0.86 to 0.81 at 2 years. Average neck ratios were calculated up to 7 years post resurfacing; 25 hips measured at 3 years average ratio of 0.81, 20 at 4 years ratio 0.8, 25 at 5 years ratio 0.8, 9 at 6 years ratio 0.8, 1 at 7 years ratio 0.81.

Discussion: A degree neck resorption occurs with this resurfacing prosthesis by 2 years, however no further resorption appears to occur beyond this, to a maximum follow up of 7 years. This may indicate that early narrowing is more likely to be due to harmless bone adaption then a progressive absorption jeopardising the femoral neck.


PJ Yates B Burston Gc Bannister

Introduction: The collarless polished tapered stem (CPT) is a double tapered cemented femoral component designed for primary hip replacement and as a revision stem for impaction bone grafting. We report the outcome at a minimum of 10 years (mean 11 years 1 month).

Methods and patients: Of 191 consecutive primary hip replacements in 174 patients, implanted using contemporary cementing techniques, 63 patients died before 10 years (68 hips). None of these stems had been revised or had radiological signs of failure at their last follow-up. Only 1 patient (2 hips) was lost to radiological follow-up, hence complete radiological data was available on 121 hips and clinical follow-up on 123 hips. The fate of all the hips is known.

Results: Survivorship with revision of the femoral component for aseptic loosening as the endpoint was 100%. The Harris hip scores were good or excellent in 75% of the patients with a mean of 86 (from 39). All the stems subsided vertically within the cement mantle at a mean rate of 0.18mm per year, stabilising to a mean total of 1.95mm (0.21–24mm) after a mean of 11 years 1 month. Unlike Exeter stems there was no change in the alignment of the stems. There was excellent preservation of proximal bone and an extremely low (< 2%) incidence of loosening at the cement bone interface.

Discussion: The study confirms that the CPT subsides within the cement mantle, but without failing. It performs at least as well as the best stems currently available.


JG Andrew D Beard J Nolan D Murray

There has been controversy about the practice of mixing femoral and acetabular implants from different manufacturers in total hip replacement (THR). We studied the clinical outcomes of over 1500 patients in the Exeter Primary Outcomes Study (EPOS) who underwent primary THR with a cemented Exeter stem (Stryker) but with various acetabular components. This was a prospective non-randomised multicentre study. Patient reported hip scores (Oxford Hip Score (OHS)) were measured before operation and at 1 and 2 years post operatively. The choice of acetabular implant was at the surgeons’ discretion. 982 patients had reached four year follow up. Six types of acetabular component were examined (Exeter, Exeter Contemporary, Duraloc (all Stryker), Charnley (DePuy), Cenator (Corin), and Trilogy (Zimmer)).

Patients who received a Charnley cup were found to have worse pre-operative status (significantly higher OHS) than those receiving other cups (especially those receiving Exeter cups) (p< 0.01). Post operatively, this difference continued, with the absolute OHS value remaining greater (i.e. worse clinical result) for the Charnley cup at 1, 2, 3 and 4 years. The association of poor pre-op status with worse post-op result was anticipated. However, when the clinical benefit of surgery (i.e. the improvement in OHS between pre-op and post-op) was assessed, there was no significant difference between the various implants at 1, 2, 3 and 4 years.

These results demonstrate that initial clinical benefit of surgery does not differ between patients receiving acetabular implants from varying manufacturers when the Exeter stem is used. These patients will be followed further to determine whether such “mixing and matching” results in differences in longer term outcomes.


M El-Deen C Armstrong D Miller

Introduction: There has been a general belief in the negative effects of increased body mass index (BMI) on the outcome of arthroplasty surgery. This study compares the complications following primary total hip replacement in obese patients.

Methods: The incidence of myocardial infarction, deep vein thrombosis, pulmonary embolism, wound infection and dislocation within the 30 days postoperative period was reviewed and compared if the BMI exceeded 30. A total of 329 patients were included in this study. There were 216 cases with BMI less than 30 compared with 113 cases of BMI more than 30. Uncemented pinnacle press-fit cup on S-ROM stem was used with 28 mm head in 137 and 36 mm head in 192 cases.

Results: There was no significant statistical difference in the incidence of early complications. However, in the subgroup of 28 mm head, there was significant increase in the infection rate when BMI was more than 30 (P< 0.032).

Discussion: In this small study, there was no significant increase in the overall incidence of the postoperative complications in obese patients. Further studies are required to assess if implant longevity is reduced in overweight patients.


SA Hobson A Karva P Howard

Introduction: Good intermediate term results have been reported using a hybrid primary total hip arthroplasty (uncemented acetabular component with cemented stem) for osteoarthritis. Concerns have been highlighted recently regarding osteolysis behind the acetabular component. We present our results using the uncemented Aesculap plasma cup with an Exeter cemented femoral stem.

Methods: Outcome of 142 primary hip replacements (124 patients) at Derby Royal Infirmary between 1992–1998 was assessed. Most cases had a 28mm articulation, either Orthinox or ceramic. There were 60 men and 64 women, of mean age 55 (range 33–71). Mean time to follow up was 8.65 years (Range 7–13 years). Radiographic assessment was made to assess wear, acetabular lysis and loosening of the components. A clinical assessment and case note review was also performed.

Results: Of 142 hips, 2 were lost to follow up and 4 patients (6 hips) had died (unrelated causes). Of these, 7 revisions were performed; 3 for osteolysis, and 1 each for infection, acetabular wear, recurrent dislocation and early cup aseptic loosening. 9 hips were identified to have asymptomatic osteolysis (6 acetabular and 2 femoral). Mean rate of linear wear was 0.2mm/year for all hips, but 0.4mm/year for those with osteolysis. No cups without supplementary screw fixation developed acetabular osteolysis.

Conclusions: Our data suggests that there is a significant rate of acetabular osteolysis at intermediate (10 year) follow up of this combination of primary hybrid total hip replacement, often in association with increased acetabular wear. This can be asymptomatic and may lead to the need for complex revision surgery in the future. The failure rate is however significantly lower than in other reported studies with the same basic implants, but differing bearing diameters. This study highlights the need for close radiographic follow up of these patients, and the issue of subtle differences in the articulating surface.


AD Patel M Albrizio

Introduction: Obesity is detrimental to the health of an individual, however does a high body mass index (BMI) actually determine post operative morbidity following hip replacement surgery?

Methods: 550 consecutive primary hip replacement patients were included in this study. Patients were followed up at four weeks, six weeks and one year following surgery. Any complication that the patient had was recorded and listed either as local or general. The complications were further sub divided into minor and major depending on the risk they posed to the patient or the joint.

Results: The average BMI of our patients was 28.3 (4.3). 56 (10%) patients had a complication following hip replacement surgery. The group who did not have any complications had an average BMI of 28.13 (SD=4.6) while the group who sustained complications had an average BMI of 29.46 (SD=5.8) with a p value of 0.104 (Student t-test). When BMI was grouped in values of 5 starting from < 25 and ending with > 35 the p value was 0.029 (chi square test). Odds ratios for grouped BMI varied from 0.086–1.61(95% CI 1.01–1.08) (p=0.086). Odds ratios for individual surgeons ranged from 0.96–2.41 (p=0.024)

Discussion: When we looked at the overall BMI there was no significant difference between the group who had a complication and the group who did not have a complication, however when the BMI was split into groups those patients in group 30–34 and 35+ experienced a higher rate of complications. The final odds of BMI was 1.05 (1.01,1.09). There was a higher complication rate in the groups other than the ideal BMI of 25–29, and even a fall in BMI caused an increase in the complication rates.

Conclusions: Obese individuals are at a higher risk of developing a complication following surgery, however the operating surgeon also has an influence on the complication rate following hip replacements.


DM Wright DH Sochart

Introduction: The C-stem total hip replacement system was devised in Wrightington in 1993 and represented the first triple tapered stem. There is little literature about the follow up outside of Wrightington and therefore we present our data on the C-Stem at a district general hospital.

Methods: This is a prospective radiological follow up of patients between March 2000 and November 2004, 250 primary hips were performed by a single surgeon using a posterior approach. Cemented all polyethylene cups were used. Initial and annual x-rays were reviewed and the following measurements were recorded: cup angle; radiolucent lines in the bone-cement interface of the acetabulum; heterotopic ossification; stem subsidence, radiolucent lines or osteolysis in the femoral component and stem orientation.

Results: Data is available on 206 hips performed on 185 patients. 107 patients were female and 78 patients were male. 72 were left sided, 92 were right sided and 21 were bilateral. The average age was 66yrs (25–89). Average follow up was 41 months (12–68). The average cup angle was 44.7 degrees. 24 patients had 0.5 mm lucencies in zone 1 of the acetabulum and 1 patient had 1mm lucency in zone 1. No lucencies were progressive. There were no lucencies in any of Gruens’s zones. 18 patients had Grade 1 heterotopic ossification, 2 Grade 2 and 1 Grade 4. 17 stems were in varus and 1 stem in valgus. Average stem subsidence was 0.83mm.

Complications were 1 fractured greater trochanter wired intra-operatively and 1 femoral nerve palsy which resolved in 3 months. There were no PE’s, dislocations or deep infections. No hip replacement has required revision.

Discussion: We conclude that at a maximum follow up of 5.5 years the C-Stem is performing to standards required by NICE and is on course to achieve the benchmark of 10% revision at 10 years.


S Dawson-Bowling K Chettiar H Cottam R Worth J Forder I Fitzgerald-O’Connor H Apthorp

Introduction: The principle causes of early death after hip fracture surgery are cardiac failure and myocardial infarction. Troponin T is a sensitive and specific enzymatic marker of myocardial injury. This study aims to assess prospectively whether Troponin T may be used as a predictor of morbidity and mortality in admissions with fractured neck of femur.

Methods: All patients aged 65 years and over presenting with a fractured neck of femur over 4 months were included. Exclusion criteria of polymyositis, renal failure and conservative fracture management were applied. Troponin T levels were measured on admission, and days 1 and 2 post surgery. According to local protocol, a level of > 0.03ng/mL was considered to be raised. Outcome measures were defined as adverse cardiorespiratory events (myocardial infarction, congestive cardiac failure, unstable angina, major arrhythmias requiring treatment and pulmonary embolism), death and length of inpatient stay.

Results: 108 patients were recruited over the 4 months. 42 (38.9%) showed a rise in Troponin T > 0.03ng/mL in at least one sample. Of these, 25 (59.5%) sustained at least one of the outcome complications including death, as opposed to 7 (10.6%) from the group with no Troponin rise (p< 0.001). The mean inpatient stay was 25.7 days for patients with elevated Troponin T levels, compared with 18.3 days in the normal group (p< 0.012). There were 9 deaths in the raised Troponin group (21.4%), and 5 (10.6%) in the group with no rise (p< 0.05).

Discussion: The association between raised Troponin and hip fractures has not previously been made. Many patients appear to be having silent cardiorespiratory or related events, which may be a significant cause of perioperative morbidity and mortality. We propose measurement of Troponin levels as part of the standard perioperative screening for hip fracture patients to identify this risk and initiate appropriate treatment measures.


R P Baker B Squires M F Gargan G C Bannister

Introduction: Arthroplasty is the most effective management of displaced intracapsular femoral neck fracture. Hemiarthroplasty (HEMI) is associated with acetabular erosion and loosening in mobile active patients and total hip arthroplasty (THA) with instability.

We sought to establish whether HEMI or THA gave better results in independent mobile patients with displaced femoral neck fracture.

Method: Eighty-one patients were randomised into two groups. One arm received a modular HEMI, the second a THA using the same femoral stem. Patients were followed for a mean of three years after surgery.

Results: After HEMI, eight patients died, two were revised to THA and there is intention to revise three. One patient had a Peri-prosthetic fracture. Mean walking distance was 1.08 miles and Oxford Hip Score (OHS) 22.5. Twenty patients (64.5% of survivors) had radiological evidence of acetabular erosion.

After THA, three patients died, three dislocated, one required revision. Mean walking distance was 2.23 miles and OHS was 18.8. There was no radiological evidence of polyethylene wear

Patients with THAs after three years walked further (p=0.039) and had a lower OHS (p=0.033).

Discussion: HEMI is associated with a higher actual and potential revision rate than THA because of acetabular erosion, higher OHS after three years and shorter walking distances.

THA is a preferable option to HEMI in independent mobile elderly patients with displaced intracapsular femoral neck fracture.


R M D Meek D B Allan G McPhillips C R Howie

Introduction: Instability after total hip arthroplasty is an important complication. Instability usually occurs in the immediate postoperative period, but the risk also increases with time. There are numerous surgical treatment options, but they have relatively unpredictable outcomes. Numerous factors are associated with dislocation, but research has mainly focused on surgical factors. Epidemiological factors remain the subject of much debate. The aim of this study was to find any such factors significantly associated with dislocation.

Methods: The Scottish National arthroplasty non-voluntary registry is based on SMR01 records (Scottish Morbidity Record) data. We analyzed the Scottish National Arthroplasty Project to find patients’ dislocation rates up to 1 year postoperatively for age, surgeon volume, gender, previous surgery, diagnosis, and follow-up duration.

Results: There were 14,314 total hip arthroplasties performed from April 1996 to March 2004. Two hundred sixty-six dislocations occurred for an average annual incidence of 1.9%. There was an association between rate of dislocation with age, surgical volume, and previous fracture. However, there was no increase in the rate of dislocation associated with gender or with diagnoses of stroke or Parkinson’s disease.

Discussion: Statistical analysis of large databases allows identification of the most relevant factors. There is a surprisingly low incidence of THA dislocation in patients with neurological conditions. This epidemiological data allows prognostic assessment of the risk of dislocation for individual patients. From this strategies can be employed to reduce the chance of dislocation in high-risk patients.


SW Veitch MR Norton

Introduction: Femoro-acetabular impingement (FAI) causes anterior hip pain, labral tears and damage to the articular cartilage leading to early osteoarthritis of the hip. Surgical hip dislocation and osteoplasty of the femoral neck and acetabular rim is a technique pioneered by the Bernese group for the treatment of FAI. We present and discuss our results of this technique.

Methods: functional outcome was measured using the oxford hip and McCarthy non-arthritic hip scores pre and post-operatively.

Results: Since January 2003, 36 hips in 34 patients (average age of 43 years (14–65)) underwent surgical hip dislocation for treatment of FAI. In 9 hips, grade 4 osteoarthritis was present in greater than 10 x 10mm regions after reshaping of the abnormal anatomy. In these cases, hip resurfacing was performed.

Of the 27 hips preserved, 14 had chondral ‘carpet’ flaps debrided, 17 underwent recession of the acetabular rim at the site of impingement, 6 had removal of medial osteophytes, 6 had labral and/or bony cysts excised and grafted and 1 underwent an osteochondral graft.

In 3 hips (12%) osteoarthritis progressed requiring hip resurfacing within the first year.

Oxford Hip Score improved from an average 36 (range 17–59) to 23 (12–45) and McCarthy hip score from 43 (9–74) to 62 (36–72) in the preserved hips at an average 15 months following surgery (range 6–33 months).

Discussion: The early results of surgical hip dislocation are encouraging. The open procedure has distinct advantages compared to arthroscopy enabling a wider range of lesions to be treated. Careful patient selection is important in order to exclude patients with hip osteoarthritis. Long-term follow-up is required to see if this technique prevents the natural progression to osteoarthritis


JV Clarke C Campbell HM Murray RMD Meek

Introduction: Despite clinical history, examination and plain radiography it is occasionally difficult to locate the origin of hip pain. This is particularly relevant where the management will be a total hip arthroplasty. Local anaesthetic arthrogram of the hip may provide a simple, safe and reliable test to determine if the hip is the source of the patient’s symptoms. The aim of this study was to establish the use of this investigation in the management of hip pain.

Methods: All local anaesthetic hip arthrograms were reviewed from 1999 to 2005. All patients had completed a pain questionnaire following the arthrogram. Patients were classified into 3 groups; 1) Mild osteoarthritic changes on plain radiographs with possible referred pathology; 2) Minimal radiological changes but no obvious other pathology to refer pain; 3) Previous hip arthroplasty with unexplained pain. Those who subsequently had a primary or revision hip arthroplasty were assessed post-operatively by means of the Oxford hip score.

Results: Fifty-seven patients in total underwent a local anaesthetic hip arthrogram. From all the groups 34 patients obtained pain relief and 24 proceeded to primary or revision hip arthroplasty. Twenty three (96%) had a satisfactory post-operative outcome at an average follow-up of 2 years (average Oxford score 28). The remaining 10 patients with positive arthrograms are still waiting for surgery. All negative arthrogram patients were successfully discharged.

Discussion: A positive response to local anaesthetic hip arthrogram predicts a successful response to surgery. This permits accurate information of the results of hip surgery to be given to patients and aids in a management plan for a group of patients that can be otherwise challenging.


S Wimsey CF Lien S Sharma PA Brennan HI Roach GD Harper DC Gòrecki

Introduction: Osteoarthritis (OA) has historically been thought of as a degenerative joint disease, but inflammation and angiogenesis are increasingly being recognised as contributing to the pathogenesis, symptoms and progression of OA. β-dystroglycan (β-DG) is a pivotal element of the transmembrane adhesion molecule involved in cell-extracellular matrix adhesion and angiogenesis. Matrix metalloproteinases (MMPs) are the main enzymes responsible for cartilage extracellular matrix breakdown and are also implicated in both angiogenesis and β-DG degradation in a number of malignancies. We aimed to investigate the expression and localisation of β-DG and MMP-3, -9, and -13 within cartilage, synovium and synovial fluid and establish their roles in the pathogenesis of OA.

Methods: Following ethical committee approval, cartilage, synovium and synovial fluid were obtained from the hip joints of 5 osteoarthritic (patients undergoing total hip replacement) and 5 control hip joints (patients undergoing hemiarthroplasty for femoral neck fracture). The samples were analysed for β-DG expression using Western Blotting and for the distribution of β-DG, MMP-3, -9, and -13 using immunohistochemistry on paraffin embedded tissue.

Results: Whilst no significant expression of β-DG was found in cartilage or synovial fluid, β-DG was expressed in the smooth muscle of both normal and osteoarthritic synovial blood vessels. Moreover, β-DG was expressed in endothelium of blood vessels of OA synovium, but not in the normal endothelium. In the endothelium of osteoarthritic synovial blood vessels, β-DG co-localised with MMP −3 and −9.

Discussion: Our results demonstrate that β-DG does not act as a cell adhesion molecule binding chondrocytes to the ECM. However, specific immunolocalisation of β-DG within endothelium of inflamed OA blood vessels suggests that β-DG may play a role in angiogenesis associated with OA. Its co-localisation with MMP-3 and −9, previously reported to also have pro-angiogenic roles, may be linked. Further research is required to understand these roles more fully.


V Ramasamy SN Sambandam M Venkatesan B Ilango

Introduction: Surgeries in elderly individuals should be less invasive and less time consuming to reduce immediate postoperative morbidity and mortality. Nevertheless it should also give optimal long-term outcome thereby avoiding subsequent procedures in these high risk individuals. Bipolar hemiarthroplasty is a commonly performed orthopaedic surgery in elderly patients with fracture neck of femur. It is commonly believed that the type of implant and the nature of fixation (cemented or uncemented) influences both the short term and the long term outcome of this procedure. In this retrospective study we compared uncemented and cemented JRI furlong prosthesis.

Method and materials: We had cohort of 60 patients who underwent cemented JRI bipolar hemiarthroplasty in the year of 2003 and 2004. We compared this cohort with the matched sample of 60 patients who underwent uncemented JRI bipolar hemiarthroplasty. We matched variables like age, ASA grade and the experience of surgeon.

Results and Discussion: The perioperative variables like duration of surgery, amount of blood loss, length of hospital stay and postoperative complications (DVT, chest infection, mortality) were found to be less in the uncemented JRI group. However there are concerns about the long-term outcome of uncemented JRI hemi-arthroplasty in the form of peri prosthetic fractures. Out of 60 patients of uncemented JRI group 3 had peri prosthetic fracture as compared to none in the cemented JRI group. We believe this complication more likely could be due to excessive canal preparation and the press fit necessary for the primary stability of the implant. This warrants further prospective controlled trials to provide more evidence on this finding.


G Holt RMD Meek

Introduction: Aseptic osteolysis represents a significant challenge to the orthopaedic surgeon as it limits the long terms survivorship of prosthetic implants.

Aim: To investigate whether the bisphosphonate aledronate alters the cytokine profile in the psuedomembrane excised from individuals undergoing revision hip arthroplasty surgery for aseptic failure.

Methods: A prospective, double-blinded, randomised controlled trial was conducted with relevant ethical approval. 10 patients were randomly assigned to receive a placebo or alendronate 70mg for a 6 week period prior to revision surgery. All individuals had aseptic failure of primary cemented femoral stems and acetabular cups with UHDPE inserts. Infection was excluded in all individuals prior to surgery. Multiple tissue samples were subsequently excised at surgery and sent for histology and culture. If either was subsequently positive for infection the individual was excluded from the study. Tissue samples were preserved using liquid nitrogen and formalin. Frozen tissue was stored at −70oC pending Polymerase Chain Reaction analysis. Formalin preserved samples were paraffin sectioned for immunohistochemical analysis. PCR was carried out to assess expression of mRNA for Interleukins 1,6,17,18; TNF alpha, RANK-L, OPG and RANK. IHC was performed to confirm protein expression in the pseudomembrane excised from the femur and acetabulum. Multiple samples were used in each patient.

Results: In the 5 individuals who received the placebo there was expression of mRNA and protein for Interleukins 1,6,17,18; TNF alpha; RANK-L; OPG and RANK in all cases. There was no statistically significant difference in the expression of any of the aforementioned cytokines/receptors in the group receiving alendronate.

Discussion: A six seek course of oral alendronate 70mg had no effect upon osteoclastogenic cytokine expression when compared to the placebo group. This would suggest that alendronate may offer little benefit in reversing established particle induced osteolysis.


JF Nolan C Darrah

A series of sixteen patients, 14 males and 2 females with an average age of 50 years (28–93) underwent total hip replacement surgery after acetabular fracture. Thirteen patients had previously undergone internal fixation of their acute fractures. Hip replacement surgery was performed by a single surgeon over an eight year period at an average of 30.36 (range 3–84) months after injury. Cases include high energy injuries as well as low energy fractures of the elderly (2 patients).

These were complex procedures due in some cases to the dramatic femoral head and acetabular bone stock loss when avascular necrosis had occurred following internal fixation. The use of acetabular mesh, allograft and reinforcement rings is discussed.

At the time of reporting the total hip replacements in this group of relatively young patients continue to be highly successful. One hip has been revised for recurrent dislocation.

This paper describes important surgical tips for the management of these complex cases. Removal of exposed metal work can be difficult. A role for MRI scanning in the early postoperative care following fracture fixation is postulated. The importance of early liaison of fracture fixation surgeons with arthroplasty colleagues leads to earlier surgery with reduction of bone stock loss.


M Halawa F Z Sadek

Neglected fractures of the acetabulum have been defined as those fractures that present to the surgical team after 3 weeks from the time of injury. Total hip arthroplasty in these cases often require a major acetabular reconstruction.

From 1989 until 2005, 38 total hip replacements were implanted in Cairo, Egypt for neglected acetabular fractures, with a follow up between 6 months and 192 months.

The male to female distribution was 33/5. The age distribution ranged from 22 to 70 years with a mean value of 47.7 years. In 30 cases, hip arthroplasty was carried out as a primary procedure due to associated acetabular cartilage damage beyond reconstruction and/or associated articular cartilage or structural damage to the femoral head. 8 cases were done after a previous attempt of open reduction and internal fixation due to failure of the reduction and fixation, avascular necrosis and/or infection.

34 acetabular components were treated by internal fixation of the columns if still mobile, autografts from the femoral head with cemented acetabular components. Four uncemented acetabular components were used in selected cases when a stable reconstructed acetabular rim was achieved. All femoral stems were cemented with the exception of five cementless stems.

At the last follow up, all grafted acetabular defects were taken with very satisfactory fixation in cemented cups. Three delayed acetabular loosening occurred at 13 years due to uncoupling of metal backed cemented acetabular components. Cementless acetabular components showed union of the fracture with stable acetabular fixation. The Merle D’Aubigne score was changed in all the cases from a range of 4/5 to 15/18.

We believe that neglected acetabular fractures can be satisfactorily treated by cemented total hip replacement using internal fixation of the columns and acetabular grafting.


T N Board K Gowaily P Hogg P Rooney P R Kay

Introduction: The success of impaction-grafting depends on mechanical stability and adequate bony incorporation of the graft. Full incorporation of this type of graft has been demonstrated histologically and depends on many factors including the biological activity of the graft. Bone morphogenic proteins (BMPs) are known to play a central role in bone formation and their presence reflects the biological activity of a graft material. The aim of this study was to determine the activity of fresh frozen femoral head (FFH) grafts by analysing BMP-7 release after milling and during strain imposed by the impaction process.

Methods: 10mm cancellous bone cubes were cut from 5 samples of FFH. The cubes were washed, centrifuged and washed again to remove the marrow contents. Specimens from each femoral head were allocated to five groups and subjected to strains of 0%, 20%, 40%, 60% and 80% with a material testing machine. The cubes were washed again and the wash fluid analysed for bmp-7 activity using a commercially available elisa kit. Additionally, samples of bone were taken after standard milling of FFH, washed and the fluid analysed for bmp-7 activity.

Results: bmp-7 activity was found to be present in all groups. Release of bmp-7 was found to increase with increasing strain in a linear relationship. At 80% strain the mean concentration of bmp-7 released (2.2 ng/g bone) was approximately double that released at 20% strain.

Discussion: activity of bmp-7 in FFH has not previously been demonstrated. This study shows that the freezing and storage of femoral heads allows some maintainance of biological activity. Furthermore we have shown that bmp-7 may be released from FFH cancellous bone in proportion to the strain applied to the bone. This may go some way to explaining the full bony incorporation often seen after impaction-grafting.


T R Madhusudhan P C Munipalle A Rangan P J Gregg

Upper gastrointestinal (GI) bleeding in patients who undergo hip and knee arthroplasty tends to be associated with NSAID use, steroid intake, pre-existing peptic ulcers and smoking. The use of Aspirin for thromboprophylaxis is an added risk for the occurrence of GI Bleed. The aim of this study was to determine if the use of peri-operative oral Ranitidine reduces the incidence of GI bleeding when Aspirin thromboprophylaxis is used for hip and knee arthroplasty.

Data from 1491 consecutive patients who underwent Hip and knee replacements at the James cook university hospital (Group 1) and 886 patients who underwent Hip and Knee replacements at the Friarage hospital, Northallerton (Group 2) was analysed to determine the incidence of Gastro intestinal Bleeding. All patients received 150 mg of Aspirin per day for a period of six weeks from the day of surgery. Additionally patients operated at the Friarage Hospital received 300 mg of oral Ranitidine per day, for three postoperative days. Patients with clinically symptomatic GI bleeding were evaluated by the Upper GI team.

We observed that patients in Group 1 had a higher incidence of overt upper GI haemorrhage (n=14), which was statistically significant (p < 0.014) compared with patients in group 2(n=1). From the pooled data of both groups, there were 18 reported patients with symptomatic pulmonary embolism (0.75%) 3 of which were fatal (0.12%), phlebitis of deep leg veins in 31 patients (1.3%), deep vein thrombosis in 34 patients (1.43%), 5 of whom had embolic episodes, post operative infection in 22 patients (1.13%), and postoperative haemorrhage in 5 patients (0.2%). Thromboembolic phenomenon and pulmonary embolism was confirmed by autopsy in the three cases.

Based on this experience, we recommend the use of peri-operative gastric protection when aspirin is used for thromboprophylaxis in hip and knee arthroplasty.


SC Budithi R. Ponnada R Pollock RK Logishetty AVF Nargol

Introduction: Experimental studies in anatomic full size hip models indicate that larger femoral heads offer potential in providing greater hip range of motion and joint stability. We studied the effects of increasing head diameter from 28mm to 36 mm in total hip replacement (THR) on the range of flexion and abduction.

Methods: 243 patients who underwent primary total hip replacement with S ROM prosthesis between July 1996 and June 2004 were studied. 151 patients (77 male and 74 female) underwent THR with 28 mm head and 92 patients (38 male and 54 female) underwent THR with 36 mm head. The range of flexion and abduction were studied and statistical analysis was performed using the Student t-test. We monitored the dislocation rate in both groups.

Results: The mean flexion is 87.0 for the 28 mm group and 89.6 for the 36 mm group. The mean abduction is 27.77 and 27.98 for 28mm and 36mm groups respectively. Even though there is a slight increase in the mean flexion and abduction from the 28mm to 36mm group, this increase in not found to be statistically significant. For flexion (2.6 (−0.85 to 3.2); p=0.377), and for abduction (0.02 (−2.37 to 1.94); p=0.847). Three hips dislocated in the 28mm group (2%) but none of the hips in 36mm group has dislocated.

Discussion: Even though experimental studies indicate improvement in range of motion with increasing head diameter in THR, this effect is not reflected in our clinical study. But there is improvement in the joint stability by using a prosthesis with larger head diameter as evidenced by a reduction in the dislocation rate.


MR Downing D Knox GP Ashcroft

Introduction: Bone loss following hip replacement is common. Its role in prosthesis stability and survival is a concern. DXA allows the assessment of adaptive bone remodelling and resorption. We prospectively examined longitudinal bone density changes affecting the Elite Plus [DePuy International Ltd], Leeds, UK), the Ultima Straight Stem (USS) [DePuy], the Exeter [Stryker Howmedica International Ltd, London, UK] and the Ultima Tapered Polished Stem (TPS) [DePuy] to determine whether bone loss was design dependent.

Methods: 164 patients were randomised to one of 4 stem designs. Patients received DXA peri-prosthetic examinations using the LUNAR EXPERT-XL at 7 days, then at

6, 12, 18 and 24 months. Custom analysis software was used to improve precision. Zones were excluded if identified as affected by heterotopic ossification post surgery. For each group the mean and standard error was determined for each follow up. 137 had follow up data to 24 months.

Results: Considering the whole peri-prosthetic region, all stems lost 5–9% BMD in the first 6 Months. The USS lost the most bone and the tapered stems, the Exeter and the TPS the least. Over the next 18 months changes were no more than 2%. The greatest losses were in the proximal zones, ranging between 8 and 20%. The USS lost significantly more (p < 0.05) than the others at 24 months. In zone 5 the TPS exhibited significantly higher recovery than the other designs at 24 months.

Discussion: Whilst the bone remodelling of the two tapered designs was largely equivalent, they exhibited a significant difference in the distal medial region. This study shows evidence that non-subsiding stems lose more bone than tapered subsiding designs.


GA McHugh KA Luker M Campbell PR Kay AJ Silman

Introduction: In the United Kingdom, the wait for hip or knee joint replacement surgery can be particularly long. There are conflicting research accounts whether debilitating symptoms, such as pain and the effects on physical function and quality of life deteriorate or remain the same in individuals who are on the waiting list for hip or knee joint replacement. This study was conducted to investigate the severity of pain, level of physical function and quality of life amongst adults with osteoarthritis awaiting hip or knee joint replacement.

Methods: A longitudinal study was undertaken in the North West of England during 2003–2005. A total of 105 patients listed for primary hip or knee joint replacement were recruited, interviewed at baseline, and followed-up at three, six and nine months, or until their joint replacement. Measurement tools used were a visual analogue scale (VAS), Western Ontario McMaster’s University (WOMAC) Osteoarthritis Index and the Medical Outcomes Study Short Form Health Survey (SF-36).

Results: High levels of pain and poor physical function and quality of life were experienced by patients on the waiting list for joint replacement. At the three month follow-up (n=84) changes in VAS pain scores (0.6; 95% CIs mean difference 0.3,1.0); WOMAC pain scores (1.2 (95% CIs mean difference 0.7, 1.8) and WOMAC physical function scores (4.8; 95% CIs mean difference 2.8, 6.7) were significantly worse compared to baseline. However, there were minimal changes in quality of life as measured by the SF-36 while on the waiting list.

Discussion: The often long wait for joint replacement surgery and deterioration in pain and physical function has highlighted the need for active management by health professionals while patients are on the waiting list. There needs to be a clinical reassessment of patients by health professionals while on the waiting list for joint replacement.


F Wadia MHA Malik J Leonard ML Porter

A secure bone cement interface between the acetabulum and the cement mantle of the hip socket is an important requirement for the long-term success of a cemented hip arthroplasty. Cement pressurisation after bone bed cleaning enables cement to penetrate interstices of cancellous bone forming a superior fixation strength.

We designed an in-vitro experiment to evaluate the performance of the Exeter, Depuy T-handle and a plunger-type pressurisers using two parameters: cement penetration and cement pressurisation.

The deformation of the flexible pressure head of the DePuy model produced a cement mantle, which is thick at the pole but tapered at its rim and variable in the amount of penetration produced (range 2–8mm) for an estimated similar force. Pressures of up to 60KPa were generated throughout the model acetabulum. The Exeter pressuriser was found to produce cement mantles more compatible with a socket. However, the test results show a wide variation in cement penetration occurring for what was estimated to be a similar applied force (3mm to 9mm at the pole and 5mm to 9mm at the rim). It was also shown to have the disadvantage of causing widely dissimilar pressures at the pole and the rim. The plunger protrusion required to produce 5mm cement penetration was found to be 7.5mm. Since this protrusion can be monitored and controlled by the operator, a cement intrusion of 5mm +/−1mm was found to be reproducible with the plunger-type device. The maximum variation in intrusion between rim and pole was 1 mm. Maximin pressures of 70KPa were generated.

We have presented experimental evidence that suggests that a plunger type of acetabular cement pressuriser may provide a more consistently reproducible level of pressurisation leading to optimal cement penetration.


TA Bucher HL Cottam H Apthorp A Butler-Manuel

Introduction: Acetabular loosening can limit long-term success of total hip replacement. There are at least 62 different prosthesis designs available in the UK, many of which have no long term results. Revision surgery is expensive, challenging and potentially dangerous. There is still currently debate about the best method of acetabular fixation, in particular, regarding the use of press fit devices in elderly osteoporotic bone. Our study aims to test the null hypothesis that there is no significant difference in outcome between cemented and non-cemented acetabular fixation in this group of patients.

Methods: Patients over 72 years of age were prospectively randomised to receive either a cemented Exeter cup or a HA coated press fit cementless cup. Both groups received a cemented Exeter stem. The patients were assessed pre-operatively and reviewed at 6 weeks, 6 months and yearly in a research clinic, by an independent observer. Outcome measures were the Merle D’Aubignon Postel, Oxford Hip and Visual analogue pain scores. The implants were also assessed radiographically and all complications were recorded.

Results: To date 151 patients have been recruited into the trial. 2 year data is available for 69 patients. There were no differences in satisfaction, pain or hip scores between the groups.

There have been no major surgical complications. In particular, there have been no failures of acetabular fixation, dislocations or deep infections.

Discussion: There have been no failures in either group. Although there is insufficient data at this stage to reject our null hypothesis, there is no early evidence for concern in using cementless cups in elderly patients.


I Rafiq T Dougall

Objective: The quality of femoral cementation is related with the long-term survival of hip prosthesis. We set out to identify if the quality of femoral cementing as assessed on the first postoperative AP radiograph was significantly different when operations performed by trainees were compared with those done by consultant staff.

The Barrack scoring system was used as a tool to evaluating cementation quality in all cases.

Material and Method: The cohort included 70 patients undergoing primary Exeter hip replacement. 41 cases were performed by consultants and 29 by trainees. The mean age of the consultant patients was 80 while in the second group this was 78. The ratio of “Funnel shaped” to “stove-pipe” femurs was 1/2.3 in the consultant group and 1/2.1 in trainees group. Thus the two groups were similar. The 1st postoperative AP hip x-rays were numbered randomly and digital images were then graded using the method of Barrack by one observer (I.R) who was blinded to the seniority of surgeon.

Results: Of the total cohort of 70 patients, 35 (50%) were grade A, 28 (40%) grade B and 7 (10%) grade C. In the consultant cases 18(44%) were grade A, 19(46%) grade B and 4(10%) were grade C. The results in for training grade surgeons were 17 (58%) grade A, 9 (31%) grade B and 3 (11%) grade C. There were no grade D cases in either group. The standard deviation in consultant group was 23.46 while in case junior grade surgeons it was 25.46.

Conclusion: The results in this series of operations suggest that in our institution, the quality of femoral cementing was not significantly different when the operations carried out by consultants were compared to those where a trainee was the primary surgeon (p=0.087). As Barrack scores have been shown to correlate with the long term survival of hip arthroplasties, these results would suggest that patients undergoing operation undertaken by an adequately experienced and supervised trainee are not at increased risk for implant failure compared to the individuals where the Consultant is the primary surgeon.


A Gul V Shanbhag S Sambandam

Patients and Methods: We conducted a retrospective study of neck of femur fractures over a period of two years. Variables analysed were the perioperative haemoglobin levels, type of fracture and surgery, age, gender and blood transfusion in the perioperative period.

Results: Out of a total of 310 patients 49 required a postoperative blood transfusion.

The mean preoperative Hb of patients who required blood transfusion was 11; S.D. 1.49 while those who did not require a transfusion it was 12.5; S.D.1.42. Transfusion was required in 23% of patients having extra-capsular neck of femur fractures fixed with a DHS and in 9.5% of patients having intracapsular neck of femur fractures undergoing a hemiarthroplasty.

The univariate analysis showed a significant relationship between post-operative transfusion and the pre-operative Hb level (p=0.0001) and the type of fracture (p=0.001). However no relationship was found between transfusion and age (p=0.423) and the gender of the patient (p=0.611).

Discussion: The results of our study indicate that the most important factor in the prediction for blood transfusion in fracture neck of femur is the preoperative level of Hb as well as the type of fracture. Predicting a priori, the target population at a higher risk of requiring blood transfusion would enable us to establish appropriate prophylactic measures.


KL Ong SM Kurtz JS Day MT Manley N Rushton RE Field

There has been renewed interest in metal-on-metal bearings as hip resurfacing components for treatment in young, active patients. This study examines the effects of fixation (cemented or uncemented heads) and bone-implant interface conditions (stem-bone and head-bone) on the biomechanics of the Birmingham hip resurfacing (BHR) arthroplasty, using high resolution, 3-d computational models of the bilateral pelvis from a 45-year-old donor. Femoral bone stress and strain in the natural and BHR hips were compared. Bone remodelling stimuli were also determined for the BHR hips using changes in strain energy. Proximal femoral bone stress and strain were non-physiological when the BHR femoral component was fixed to bone. The reduction of strain energy within the femoral head was of sufficient magnitude to invoke early bone resorption. Less reduction of stress was demonstrated when the BHR femoral component was completely debonded from bone. Bone apposition around the distal stem was predicted based on the stress and strain transfer through the stem. Femoral stress or strain patterns were not affected by the type of fixation medium used (cemented vs. Uncemented). Analysis of proximal stress and strain shielding in the BHR arthroplasty provides a plausible mechanism for overall structural weakening due to loss of bony support. It is postulated that the proximal bone resorption and distal bone formation may progress to neck thinning as increasing stress and strain transfer occurs through the stem. This may be further exacerbated by additional proximal bone loss through avascular necrosis. Medium term retrieval specimens have shown bone remodelling that is consistent with our results. It is unclear if the clinical consequences of neck thinning will become more evident in longer-term follow-ups of the BHR.


S Sturridge J Hua SP Ahir J Witt P Nielsen R Bigsby GW Blunn

Introduction & Aims: A new femoral component for hip arthroplasty has been designed for a younger patient population. The design makes use of a higher femoral cut, which conserves bone stock, increasing options for future revision surgery. It uses the existing load bearing properties of the proximal femur, and therefore distributes load more evenly. The stem is longer than that of a resurfacing, so will be easier to insert at the correct orientation, minimising failure rates in inexperienced hands. The cross-sectional dimensions have been designed to produce torsional stability. The collar maximises the loading of the calcar, reducing stress resorption. The surface is hydroxyapatite coated and porous, which will produce a long-term biological fixation.

This project assessed the long-term stability of this design at different orientations, by measuring the change in surface strain distribution following its insertion.

Methods: Ten composite bones were coated in a Photoelastic material, positioned at a simplified single leg stance, and loaded at 2.3 KN. The surface strain was measured at one-centimetre intervals down the medial cortex. Then the prostheses were inserted into the bone at 135°, 145° and 125° to the femoral shaft, and the surface strains reread.

Results: The results were compared with an FEA model, and analysed statistically using the Wilcox signed rank test. The prosthesis inserted at 135° produced no significant difference in surface strain distribution compared with the intact bone.

Conclusions: This study suggests this stem design will be stable in the long term following insertion, and there were no areas of excessively high or low strain.


MT Manley KL Ong SM Kurtz N Rushton RE Field

One potential limitation with uncemented, hemispherical metal-backed acetabular components is stress shielding of bony structures due to the mismatch in elastic modulus between the metal backing and the peri-prosthetic bone. A proposed substitute is a horseshoe-shaped acetabular component, which replicates the bony anatomy. One such device, the Cambridge cup, has shown successful clinical and radiological outcomes at five years follow-up (Brooks 2004, Field 2005). We conducted a study of the Cambridge cup from a biomechanical perspective, using validated, high-resolution computational models of the bilateral hip. Peri-prosthetic stress and strain fields associated with the Cambridge cup were compared to those for the natural hip and a reconstructed hip with a conventional metal-backed hemispherical cup during peak gait loading. We found that the hemispherical cup caused an unphysiologic distribution of bone stresses in the superior roof and unphysiologic strain transfer around the acetabular fossa. These stress distributions are consistent with bone remodelling. In contrast, the peri-acetabular stresses and strains produced by the Cambridge cup differed from the natural hip but were more physiologic than the conventional hemispherical design. With the Cambridge cup, stresses in the superior acetabular roof, directly underneath the central bearing region, were greater than with the conventional design. Despite the thin bearing, the peak liner stresses in the Cambridge cup (max. tensile stress: 1.2 MPa; yield stress: 4.5 MPa) were much lower than the reported material strengths. Fossa loading by the hemispherical cup has been suggested as a possible mechanism for decreased implant stability (Widmer 2002). Conversely, the Cambridge cup produced semi-lunar peri-prosthetic stress fields, consistent with contact regions measured in natural hips (Widmer 2002). These analyses provide a better understanding of the biomechanics of the reconstructed acetabulum and suggest that a change in component geometry may promote long-term fixation in the pelvis.


BC Hanusch

Introduction: Fragility fractures are taking up an increasing amount of resources within Trauma departments. Women have a 1 in 3, men a 1 in 12 lifetime risk of sustaining an osteoporotic fracture with a previous fracture being the strongest independent predictor of sustaining a further fragility fracture, often within one year. Secondary prevention is therefore particularly important. Many guidelines give advice on secondary prevention in women, but very few mention men even though men have a higher morbidity and mortality after hip fractures.

Methods: A retrospective review was carried out including 91 patients (48 females, 43 males) who were admitted with a fragility hip fracture between March 2003 and April 2004. Data about age, sex, investigations and medication were collected from the case notes, GP surgeries and the bone densitometry database. Investigations and treatment were compared with current guidelines (SIGN 2003, NICE 2005). Data was analysed using SPSS Version 13.0.

Results: 33% of women and only 8% of men < 75 years of age were investigated for osteoporosis (DEXA scan) following their hip fracture (Fishers Exact Test, p = 0.32). In patients ≥ 75 years 25% of women and only 6% of men were treated with bisphosphonates (χ2 = 4.18, p < 0.05). There was also a statistically significant difference in overall treatment including bisphosphonates and calcium/vitamin D between the sexes (χ2 = 6.81, p < 0.05).

Discussion: This study shows that there is a great need for improvement in secondary prevention of osteoporotic fragility fractures in both sexes, but men are far less likely to receive investigations and treatment than women. It is therefore essential to include recommendations for men in future guidelines and to increase awareness of male osteoporosis. Orthopaedic surgeons should take responsibility for initiating the process of secondary prevention.


J Daniel C Pradhan H Ziaee DJW McMinn

Introduction: Dislocation rates with THA vary from 3% to 15%. One specialist centre reported a 6.4% early dislocation rate with a 28mm ceramic on polyethylene THA in young patients (mean age 56 years) in a single surgeon series. Although young patients have the advantage of better soft tissues, their greater mobility demands increase dislocation risk.

Dislocation rates in large headed metal-on-metal resurfacings are extremely low. However, many patients are unsuitable for resurfacing and need a replacement. In such cases, it is attractive to transfer the large-headed metal-metal bearing advantage to replacement arthroplasty in order to reduce wear and dislocation rates. Does large diameter metal-metal total hip replacement really reduce the early dislocation rate?

Methods: 206 consecutive primary metal-metal THRs (189 patients) were included. The device consists of an uncemented cup, a matching modular cobalt chrome head (head diameter ranged 38 – 58mm) fixed on a stem through a 12/14 cone. Cemented stems were used in 107 procedures and 99 were proximal-porous uncemented stems.

Age at operation ranged from 37 to 83 years. Thirty patients were 55 years or under, eighty one were 56 – 65 years and ninety five were over 65 years. There were 122 females and 67 males. Posterior approach was used in all.

Results: There were no dislocations in these 206 consecutive procedures.

Discussion: Metal-metal hips have lower dislocation rates than hips containing polyethylene (0.9% against 6.4% in a matched series). This is attributed to the suction-fit effect of metal-metal bearings. Large diameter bearings have the additional benefit of having to translate a greater jump distance before a dislocation. This dual advantage leading to extremely low dislocation rates was first noted in metal-metal resurfacings. In large headed metal-metal THRs, the head-neck ratio is even more favourable and these devices appear to eliminate early dislocation as a major complication.


RF Spencer RA Nelson

Introduction: The advent of metal on metal resurfacing in the United Kingdom has resulted in increasing interest in the procedure. The operation is more demanding than primary joint replacement and the complications involved are frequently peculiar to the technique. We present a single-surgeon series from a district hospital performed within the ambit of a larger multicentre study.

Method: Data on 83 cases in 80 patients (51 males, 29 females, age 34y–68y, mean age 50.6y) were collected. Patients were reviewed preoperatively and postoperatively at 6 months and annually (mean 21 months, range 1–60 months). At review Harris Hip scores were recorded with a radiological assessment to assess implant orientation. Technical difficulties with implant insertion were recorded. All cases were approached via an anterolateral exposure.

Results: Postoperative scores improved dramatically in nearly all cases. There was persistent pain in two cases, one of spinal origin, the other unexplained. 2 loose femoral components were revised at 2 and 3 years respectively years leaving the intact cup. 1 cup rotated slightly over 3 months and stopped, 4 cups were incompletely seated and 1 femoral component was inserted in slight varus. All remain asymptomatic to date. There was one unrelated death (mesenteric infarction) and no femoral neck fractures.

Discussion: Resurfacing arthroplasty is technically more demanding than total hip replacement and the exchange of experiences via a multicentre user group is important. The conservative nature of the device means that revision for fractured neck of femur (commonest cause of failure) to a stemmed implant retaining the cup is relatively easy. The results of this series are encouraging.


ET Davis M Olsen R Zdero JP Waddell EH Schemitsch

Introduction: It has been suggested that femoral component alignment in the coronal plane affects the risk of sustaining femoral neck fracture following hip resurfacing. Previous literature suggests that increasing the stem shaft angle to an extreme valgus position produces the most favourable biomechanical properties following femoral component insertion. We examined the effects of femoral component alignment during hip resurfacing on proximal femur strength.

Methods: 3rd generation composite femurs shown to replicate biomechanical properties of human bone were used. The bones were secured in a position of single leg stance and tested with an Instron mechanical tester. Imageless computer navigation was used to position the guide wire during femoral head preparation. Specimens were placed in 115, 125 and 135 degrees of stem shaft angulation. No notching was made in the femoral neck during head preparation. The femoral components were cemented in place. Radiographs were taken ensuring that stem shaft angles were correct. Specimens were loaded to failure in the axial direction.

Results: A component position of 115 degrees compared to 125 degrees reduced load to failure from 5475N to 3198N (p=0.009). A position of 135 degrees (5713N) compared to 125 degrees (5475N) did not significantly alter the load to failure (p=0.347). Component positioning at a stem shaft angle below 125 degrees resulted in a significant reduction in strength of the proximal femur. Placement of the component at 115 degrees reduced the load to failure by 42%.

Discussion: Our findings suggest that a varus orientation may be at risk for causing femoral neck fracture. The advantages of increasing valgus angle beyond 125 degrees may not provide as much reduction in the incidence of femoral neck fracture as previously suggested, particularly when considering the inherent risk of femoral neck notching in these positions.


SC Budithi PK Mereddy RK Logishetty AVF Nargol

Introduction: Design of the prosthesis is an important factor in the successful outcome and longevity of total hip replacement. The purpose of the present study is to evaluate the minimum six-year results of primary total hip replacement using LX cemented prosthesis.

Methods: We prospectively studied 177 patients (60 male and 117 female) who underwent 197 hip replacements, between 1996 and 1999, using LX cemented prosthesis comprising a femoral component with cylindrical cross section of the stem and an acetabular component of ultrahigh molecular weight polyethylene. The average follow up was 7.3 years (6.1–9.6years). Clinical (Harris Hip Score) and radiological assessments (Barrack’s grading of cementation, subsidence, debonding, radiolucent lines and osteolysis) were performed.

Results: The average Harris Hip Score is 85.53 (28–99) compared to the preoperative score of 59.28. 28 cases (14.2%) developed progressive radiolucent lines around the stem. Sinking and debonding of the stem was noted in 18 cases (9.1%). 15 hips (7.6%) have dislocated and 11 were recurrent dislocations. Revision hip replacement was carried out in 12 cases (6%) for subsidence and debonding of stem, cement fracture and recurrent dislocation. The femoral stem components were found to be loose at the time of surgery.

Discussion: We believe that design of the prosthesis is an important factor in the high incidence of subsidence and debonding of the femoral stem. Both the geometry (cylindrical shape) and the rough surface finish (Ra value 100 microinches) were responsible for the pattern of progressive loosening. Lack of progressive increase in the offset with increase in the size of femoral component from 1 to 2 is one of the factors which contributed to high incidence of dislocation.


ET Davis S Kureshi M Olsen M Papini R Zdero JP Waddell EH Schemitsch

Introduction: Notching of the femoral neck during preparation of the femur during hip resurfacing has been associated with an increased risk of femoral neck fracture. We aimed to evaluate this with the use of a finite element model.

Methods: A three dimensional femoral model was used and molded with a femoral component constructed from the dimensions of a Birmingham Hip Resurfacing. Multiple constructs were made with the component inferiorly translated in order to cause a notch in the superior femoral neck. The component angulation was kept constant. Once constructed the model was imported into the Ansys finite element model software for analysis. Elements within the femoral model were assigned different material properties depending on cortical and cancellous bone distributions. Von Misses stresses were evaluated near the notches and compared in each of the cases.

Results: In the un-notched case the maximum Von Mises stress was only 40MPa. However, with the formation of a 1mm notch the stress rose to 144MPa and in the 4 mm notch the stress increased to 423MPa. These values demonstrated that a 1mm notch increased the maximum stress by 361% while a 4mm notch increased the maximum stress by 1061%.

Discussion: This study demonstrated that causing a notch in the superior femoral neck dramatically increases the stress within the femoral neck. This may result in the weakening of the femoral neck and potentially predispose it to subsequent femoral neck fracture. The data suggests that even a small notch of 1mm may be detrimental in weakening the femoral neck by dramatically increasing the stress in the superior neck. This study suggests that any femoral neck notching should be avoided during hip resurfacing.


JG Andrew D Beard J Nolan D Murray

There is concern that patients undergoing total hip replacement by trainee surgeons may do worse than those operated on by consultants. We examined the clinical outcomes of over patients in the Exeter Primary Outcomes Study who underwent primary THR with a cemented Exeter stem (Stryker) with various acetabular components. Over 1400 patients entered the prospective non-randomised multi centre study. Patient reported hip scores (Oxford Hip Score (OHS)) were measured pre operation and at 3 months, 1,2,3 and 4 years post operatively.

The number of patients assessed at 4 years was 982. Trainees operated on patients with worse pre-operative OHS (p< 0.05; t test)) and on significantly less patients under 60 years (p< 0.05 chi square). There was no significant difference in the improvement in OHS (i.e. pre-op OHS – post-op OHS) at any post-operative time point between consultants and trainees. However, patients operated upon by consultants had consistently better postoperative absolute OHS scores (p< 0.05 at 3 months and 1, 2, 3 and 4 years; t test). Complications were low in both groups. Operations performed by trainees lasted longer (mean of 104 vs. 85 minutes). There was also no difference in OHS scores of patients operated by trainees whether they were assisted by an SHO (n=132) or by a consultant (n=249).

In this large cohort of patients there was no difference in the improvement in OHS between patients operated by registrars and consultants. The difference in the absolute OHS values is likely explained by the difference in pre-operative status. We conclude that THRs performed by consultants and by trainees under appropriate supervision give similar initial clinical results. Given current changes to shorten surgical training, it is important that outcomes of THRs performed by future trainees are reviewed to ensure that outcomes are maintained.


ET Davis M Olsen R Zdero JP Waddell EH Schemitsch

Introduction: It has been suggested that notching of the femoral neck during hip resurfacing weakens the proximal femur and predisposes to femoral neck fracture. We aimed to examine the effect of neck notching during hip resurfacing on the strength of the proximal femur.

Methods: 3rd generation composite femurs that have been shown to replicate the biomechanical properties of human bone were utilised. The bone was secured in a position of single leg stance and tested with an Instron mechanical tester. Imageless computer navigation was used to position the initial guide wire during head preparation. Six specimens were prepared without a superior notch being made in the neck of the femur, six were prepared in an inferiorly translated position to cause a 2mm notch in the superior femoral neck and six were prepared with a 5mm notch. The femoral component was then cemented in place. All specimens had radiographs taken to ensure that the stem shaft angle was kept constant. The specimens were then loaded to failure in the axial direction.

Results: The 2mm notched group (mean load to failure 4034N) were significantly weaker than the un-notched group (mean load to failure 5302N) when tested to failure (p=0.017). The 5mm notched group (mean load to failure 3121N) were also significantly weaker than the un-notched group (p=0.0003) and the 2mm notched group (p=0.046). All fractures initiated at the superior aspect of the neck, at the component bone interface. All components were positioned in the same coronal alignment +/−2 degrees.

Discussion: A superior notch of 2mm in the femoral neck weakens the proximal femur by 24% and a 5mm notch weakens it by 41%. This study provides biomechanical evidence that notching of the femoral neck may lead to an increased risk of femoral neck fracture following hip resurfacing.


VM Budnar R Maheshwari GC Bannister

Introduction: The purpose of this study was to evaluate the effect of preoperative oral ferrous sulphate supplementation on the haemoglobin status of a group of patients undergoing primary THA and the incidence of homologous blood transfusion in them.

Methods: The authors prospectively studied 107 consecutive patients scheduled to undergo primary THA. All the patients were given ferrous sulphate, 200mg twice a day for a minimum of 21 days, six weeks prior to their proposed operation. We excluded patients on medications that can interfere with iron metabolism.89 patients managed to complete the course. To aid compliance the investigators collected tablet bottles after completion of the course. Haemoglobin (Hb), Mean Corpuscular Haemoglobin and Mean Cell Volume was conducted at the start, on the day before surgery and the second postoperative day. The details for blood transfusion were also recorded. We compared these patients to control group of demographically similar 90 patients, who did not have iron supplementation.

Results: 19 patients (21%) were anaemic at the start of the therapy.72 patients had rise in their haemoglobin by a mean of 0.61 g. In the study group16 patients (18%) had a blood transfusion as compared to 23 patients (26%) in the control group. Patients with preoperative Hb above 13.5g did not require transfusion in both study and control group.15 patients in the study group increased their Hb above 13.5 gdl, and were likely saved from requiring a transfusion. The relationship between the iron status and blood transfusion requirement was not statistically significant.

Discussion: The incidence of preoperative anaemia is significant in patients undergoing THA. Ferrous sulphate therapy on its own did not reduce the blood transfusion requirement. Non-anaemic patients seem to benefit most with iron supplementation, in terms of avoiding blood transfusion. Combination of early screening, appropriate treatment pre-operatively and strict guidelines may help reduce the incidence of blood transfusion.


KN Subramanian AJ Temple SL Evans A John

Introduction and aim: prosthesis displacement while attempting closed reduction of a dislocated total hip or during dislocation itself is a rare but significant complication. We have come across three cases and there are at least six case reports in the literature. The aim of our study is to conduct an in vitro biomechanical study to assess, whether application of bone cement over the shoulder of the stem confers any additional advantage in the pull out strength of the implant.

Materials and Methods: We used fourteen saw bones and cemented seven bones with a standard cementing technique and another seven bones with additional cement over the shoulder of the implant. A tensile testing machine was used to assess the pull out force needed in both groups. A comparision was done between both groups.

Results: The mean pull out force in the routine cementing technique was 2066N(S.D. 256.65) and for the group with the cement on the shoulder was 3220N(S.D. 312.22). The mean difference was 1154N. The results were analysed with two-tailed t- test, unequal variance and the difference was statistically significant with p value of 0.00045.

Conclusion: Our experiment confirms that application of the bone cement over the shoulder of the implant does give additional axial stability and should be practised routinely to reduce this complication.


WJ Hart R Banim JP Hodgkinson

Introduction: Recurrent Instability of the hip remains a difficult problem to treat successfully. The Posterior Lip Augmentation Device (PLAD) is a useful option where there is no gross mal-orientation of the components.

Methods: A retrospective single surgeon review was performed to identify patients who had undergone application of a PLAD to treat recurrent instability. Patients with less than 12 months follow up were excluded.

Results: 14 patients were identified with an average age of 75.5 years (Range 59 – 90 years). There were 7 cases of trochanteric non-union as a result of previous surgery. The mean follow up was 26 months (Range 13 – 41 months). In 13 patients there have been no further instances of dislocation. 1 patient went on to dislocate again and has now undergone a socket revision.

Conclusion: Application of the Posterior Lip Augmentation Device is a well tolerated procedure with very favourable success rates (93%). Given the limited morbidity and short operating time associated with this surgical option it provides a predictable outcome in cases where the original components are well orientated and securely fixed.


MR Downing D Knox GP Ashcroft

Introduction: Heterotopic ossification (HO) is common post total hip replacement. Dual energy x-ray absorptiometery (DXA) is an established technique used to assess peri-prosthetic, bone mineral density (BMD) changes in the femur following surgery. The effect of HO on these measurements has not previously been reported. In this study we investigated the incidence and distribution of HO and the extent to which it affected peri-prosthetic DXA results.

Methods: As part of a two-year, prospective, primary cemented THR trial, 137 patients were assessed at six month intervals with DXA as well as anterior-posterior and lateral radiographs. HO was identified from radiographs and then further localised to the seven femoral Gruen zones using DXA subtraction imaging.

Results: HO affected at least one Gruen zone in 46% of study patients. The mean BMD in zone 1 dropped to 89% of the postoperative value in unaffected patients by six months whereas it actually increased to 102% in the HO patients (p< 0.001). This 12% difference persisted throughout the duration of the trial. Zone two was affected in 17 patients and a significant gain of 5% was noted in these patients at 12 months (p< 0.05). From observation of AP x-rays alone, 12% of the HO cases would have been missed.

HO was found to be significantly associated with male gender and increasing age at time of operation. Surgical approach to the hip also had an effect, osteotomies producing a greater incidence of HO formation.

Discussion: HO has a dramatic effect on BMD values determined by DXA. This has not previously been reported and may have affected other peri-prosthetic studies. We recommend careful screening for HO when reporting femoral peri-prosthetic BMD changes.


D Marsland RW Simpson-White C Ruddlesdin

Cementless total hip replacements (THR) have a theoretical advantage over cemented designs in that bone lysis and probably aseptic loosening are less common complications. NICE guidelines suggest that prosthesis should have an aseptic loosening rate of < 10% at 10 years. Long-term follow-up of the Joint Replacement Instrumentation (JRI) Hydroxyapatite coated (HAC) Furlong system is gradually emerging following its first clinical application in 1985.

A retrospective study was performed to identify all patients having undergone a primary JRI HAC THR under a single Consultant at Barnsley Foundation Hospital NHS Trust between 1985 and 1995. This identified 124 joints in 106 patients (52% males). All living patients were sent a modified Oxford Hip Score questionnaire; case notes were also reviewed to identify any revision surgeries.

Median age at operation was 54.0 years. 17 patients (16%) had died at the time of this study. Median follow-up was 13.7 years (range 9.4–18.5 years). For 30 patients (24.2%) it was impossible to gather data on the survival of the hip.

Mean survival of all hips followed up was 16.2 years. Twenty-four hips (19.4%) required revision surgery; the median time to this surgery was 10.2 years, mean 8.2 years. Reasons included aseptic loosening of the stem in one patient at 12.7 years, aseptic loosening of the cup in 7 patients (range 10.2–17.4 years), worn polythene insert in 4 patients, infective loosening in 3 patients and recurrent dislocations in 2 patients. The remainder of revisions were for unknown reasons.

The Oxford Hip Score postal questionnaire was returned by 79% of patients. Mean score was 12.6/45 but 88% of patients reported overall satisfaction with the hip.

In summary, there were no revision surgeries at ten-year follow-up for aseptic loosening.


MJ Jones MJ Oddy CJ Pendegrass J Pilling JA Wimhurst

Introduction: Templating of radiographs is part of pre-operative planning in Total Hip Replacement (THR). Digital radiograph technology allows the manipulation of images, altering magnification and therefore affecting accuracy and reproducibility in templating. We have performed a study to investigate templating for hybrid total hip arthroplasty comparing digital hard copies with three computer methods to scale for magnification, in order to assess whether on-screen images can be templated directly with existing acetate templates.

Methods: 20 patients undergoing hybrid THR had pre-operative radiographs taken with a 10 pence coin attached to the skin overlying their greater trochanter. On-screen computer images were manipulated using either the 10p coin as a marker to scale for magnification, or two digital line methods using computer software against external ruler scales. Templating were performed for acetabular size, femoral offset, stem offset and stem size by three grades of observer, and the on-screen images were compared with hard copy digital prints. Intraclass Correlation (ICC) analyses were performed to assess intra-observer and inter-observer variability for the four methods. Comparisons were also made between templated results and the sizes of the inserted prostheses.

Results: All methods showed good reproducibility with all ICC values for intra-observer variability greater than 0.7. Inter-observer variability was less consistent, and the two digital line methods were the least reliable, with accuracy of sizing compared with the inserted prostheses varying between −1.6% to +10.2%. The hard copy radiographs showed better reproducibility than the 10p method, but less accuracy with 3.7% under-sizing. The 10p method was most accurate, with no significant differences for offset or acetabulum compared with the inserted prostheses, and templated under-sizing of only 0.9%.

Discussion: On-screen templating of digital radiographs with standard acetate templates is accurate and reproducible if a radio-opaque marker such as a 10p coin is included when taking the original radiograph.


RS Kotwal V Shanbhag A Gaitonde K Singhal

Introduction: The incidence of tuberculosis has increased by almost 30% annually in the UK. Orthopaedic surgeons are more likely to encounter patients affected with Mycobacterium tuberculosis [MTB]. We have reviewed the surgical and medical management of cases of MTB infecting prosthetic hip joints in patients without previous tuberculosis.

Report: A 59 year old Caucasian woman presented to us with apparent osteoarthritis hip. X-rays confirmed osteoarthritis but also revealed a lytic lesion in the greater trochanter and erosion of the superior cortex of the femoral neck. The patient had no prior history of exposure to tuberculosis and no evidence of pulmonary or osteoarticular tuberculosis. The patient was investigated preoperatively with blood tests, bone scan, CT scan, CT guided FNAC, and core biopsy. None of these showed any specific diagnostic features. She underwent a total hip replacement and was asymptomatic up to 15 months post-op when she presented with pain in the joint with an abscess over the gluteal region. The abscess was drained and special media culture grew MTB. We used 4-drug therapy for 12 months with retention of the prosthesis and a good functional result.

Discussion: Infected total hip replacement presents a management challenge and surgeons should have a high index of suspicion for Tuberculosis in recalcitrant infections where smears from infected joints are negative. The infection of a total hip replacement with MTB in patients without previous tuberculosis is very uncommon. Only 12 cases have been reported in a search of English language literature from 1966–2005.

We have analysed the wide variation in the management of these cases. The majority of authors in our review resected or revised the infected prosthesis. We are of the opinion that if the infection is clinically under control and the prosthesis is stable, medical treatment alone should suffice.


WJ Hart JP Hodgkinson

Aim: To determine if it is possible to predict the pattern of socket failure from the first post-operative x-rays.

Methods: A retrospective review was performed of patients undergoing revision hip surgery for aseptic socket loosening. An assessment was made of the pattern of failure and socket migration. Operative details of bone defects and reconstructions required were noted.

Results: 55 patients were identified with an average age of 46.2 years at primary surgery. The average socket survival was 16.14 years. There was no association between the patient’s age or original diagnosis and the duration of socket survival.

Supero-medial migration was seen in 27 (49%) of cases, demarcation without migration was seen in 18 cases (33%) and supero-lateral migration was seen in 7 (13%) cases. There were 2 (4%) socket fatigue fractures due to wear. There was 1 (2%) patient with a worn socket and no loosening.

Reconstruction was achieved by impaction bone grafting alone in 25 cases, IBG and a block allograft in 9 cases, cement alone in 8 cases and IBG with a rim mesh in 4 cases.

In cases where the supero-lateral margin of the socket was covered by host bone, failure always occurred by demarcation alone or in association with supero-medial migration. Rim defects significant enough to require reconstruction were seen in only 4 of these 45 patients (9%). Failure by supero-lateral migration was only seen in the cases of DDH where the socket was left uncovered or where the socket had fractured.

Conclusions: In this young age group series cemented acetabular components performed well, failed predictably and were relatively straightforward to reconstruct.

The pattern of socket failure can be reliably predicted from the original post-operative x-rays. Care should be taken to ensure adequate supero-lateral coverage in order that demarcation and migration leave an intact rim for reconstruction.


S Malek V Neelapala I Ahmad L McSweeney

Background: The exact incidence of cancer (primary/metastatic) leading to pathological fracture in femoral neck is not clear. Bone specimen is often sent for histology in suspicious cases. This retrospective study was aimed to answer the above question and to review our hospital practice in managing these patients.

Materials & Methods: All patients with fracture neck of femur undergoing surgery and had bone specimen taken for histo-pathological examination between 01.01.2002 and 31.12.2003 were included. Case notes and histology reports were reviewed.

Results: Out of total 533 patients with femoral neck fracture, 32 (6%) patients had bone specimen taken for histology. 9 male & 23 female patients with mean age of 82 years. 58% had past history of cancer (commonest being breast) with/without suspicious lesion on x-rays where as the remaining had no history of cancer but suspicious lesion on x-rays. 4 (12.5%) had positive histology results. All four had metastatic disease (2 from breast, 1 from renal and 1from multiple myeloma). Only 19% had results documented in case notes but 81% had reports filed in notes. Appropriate referral was made to oncology team for three patients. The fourth patient with multiple myeloma died in hospital before the referral. Four of 28 (14%) patients with negative results died within 3 years following the surgery compared to only 1 (multiple myeloma) out of 4 patients with positive results.

Conclusion: The incidence of suspicious pathological femoral neck fracture was 6% but incidence of cancer was 0.7%. All positive cases were metastatic. Commonest primary was from breast – adenocarcinoma). Mortality in negative cases was 16% at average of 3 years compared to 25% in metastatic fracture patients.


ME Kent R Rachha MK Sood

Introduction: We describe a novel, innovative and inexpensive method of producing a reinforced articulating cement spacer using a commercially available hip cement mould.

Methods: After adequate debridement and removal of original implants during the first of a two-stage revision procedure, an articulating cement spacer is created using a conventional mould and is reinforcing using a central stainless steel rod extending from the head to the tip using a novel technique that will be described in detail.

Results: We currently have a cohort of six consecutive patients in whom this novel cement spacer has been used. All patients were able to at least partially weight bear and none of the spacers fractured. Five have been explanted at second stage surgery after a minimum of 8 weeks in situ. One patient has been unable to undergo a second stage due to medical co morbidities and continues to mobilise with walking aids on the spacer 1-year post implantation.

Discussion: The articulating cement spacer described is produced using a technique that is simple, reproducible and allows a reinforced spacer to be created inexpensively without the need for special equipment. The spacer described provides a number of advantages over previously described or currently available commercial cement spacers. As it is reinforced it provides increased strength and allows partial weight bearing without risk of spacer fracture, a recognised complication of unreinforced spacers. As it uses a mould the surface remains smooth allowing easier insertion and minimising further bone loss with articulation. As it is fabricated intra-operatively, rather than being premanufactured, antibiotics can be added to the cement used to make the spacer according to known organism sensitivities.

Conclusion: We describe the first ever smooth, articulating, moulded cement spacer that can be inexpensively fabricated intra-operatively without the requirement for special equipment.


M Bhattacharyya H Bradley

Introduction: Doctors spend less consultation time giving information to the patients [Cegala] and underestimate the patients’ desire for information [Teutsch C 2003]. The communication gap is more visible when people with chronic arthritis present themselves for treatment. This also may initiate medico legal claims in NHS.

We aim to set up a nurse practitioner clinic to bridge the gap. Secondary aim is to reduce patients’ complaint about the services.

Materials: 100 questionnaires filled up by the patients on the waiting list for joint replacement, attending the specified clinic over a period of 24 months were randomly selected for analysis. Equal no of males and females were taken to eliminate gender bias on the outcome.

Methods: Patients were given detailed generic information about pre and post surgery nursing care, the operative steps and complications. They were asked to fill up 6 item questionnaires to assess the qualitative aspect of service at the end of the clinic and another 12 item questionnaires to fill up separately 6 weeks prior to their operation.

Result: 98% reported the information provided is excellent. 93% reported the clinic is excellent, as they have been told about the complication and pre and post surgery events. There is a reduction of rate of cancellation of elective joint replacement surgery from12.4% to 4.6%

Conclusion: This kind of informal group discussion enable patients with arthritis needing joint replacement to get information and aware of the kind of support available to cope in the community. We found there is a reduction of patients’ complaints about the service and effectiveness of this programme in reducing postoperative complications and use of bed days, use of own transport to return home. This may potentially lessen financial burden to the care provider.


DT Loveday FA Carroll NJ Donnachie

Introduction: The management of total hip replacement (THR) dislocations is variable after closed reduction. This study was performed to look at the differences in immediate management of THR dislocations after reduction under anaesthesia.

Method: A questionnaire was sent to all members of the British Hip Society asking them about their management of THR dislocations after closed reduction.

Results: 62 orthopaedic consultants completed the questionnaire. A 34% return rate for our postal survey to the 2004 members of the British Hip Society.

For first time dislocations with a stable EUA 8% always used an abduction brace and 50% never used one. 20% were managed with a period of bed rest. For an unstable EUA, 40% always used a brace and 23% never used one. 31% were managed with a period of bed rest. When a brace was used, the majority (75%) used it for 6 weeks (range 2 to 12 weeks).

For recurrent dislocations, with a stable EUA, 65% used a brace for at least 6 weeks. For an unstable EUA 74% used a brace for at least 6 weeks and 15% managed with a brace permanently or until revision.

50% asked the patient to wear the brace 24 hours a day including whilst asleep, the only exception being for washing. The others were varying from 12 to 16 hours a day.

The commonest criteria for revision surgery were recurrent dislocation (seen as more than three), component malposition, aseptic loosening and instability at EUA. The questionnaire was answered by orthopaedic surgeons who all had experience in revision surgery, the majority having performed over 100 revision THR in the past 5 years.

Discussion: The management of dislocated THR is varied between units. There does not appear to be a pattern of management amongst BHS members. The popularity and efficacy of abduction braces remains unknown.


S Malek I Ahmad V Neelapala N Kanvinde

Introduction: It was noted that INR levels transiently increased before dropping after stopping warfarin pre-operatively in warfarinised patients with femoral neck fractures. Surgery was more likely to be delayed in these patients. The aim of this retrospective study was to determine the trend of INR level after stopping warfarin and to determine the morbidity and mortality in these patients.

Material and Methods: All patients with femoral neck fracture who were on warfarin between 01.01.2002 and 31.12.2003 were included. Case notes and haematology reports were reviewed.

Results: 22 (4.2%) out of 533 patients with femoral neck fractures were found to be on warfarin on admission. 21 case notes were obtained. 7 male and 14 females with mean age of 81 years. In 11 (52%) cases, INR level increased before coming down after stopping warfarin. 60% of them had morphine as analgesic compared to 40% in the other group. Average rise in INR was 0.4. Average delay in surgery due to high INR was 3.5 (range 1–8) days. It took average of 4 days to achieve desirable INR after restarting warfarin. 6 (28%) needed blood transfusion. Nine (43%) patients developed complications including: intra-operative bleeding-1, postoperative DVT-1, fast AF-2, post-operative anaemia-1, other medical-3. One patient (5%) died from large CVA 12 days after surgery. No further mortality was found within 30 days of surgery.

Conclusion: Incidence of femoral neck fractures on warfarin was 4.2%. In over half of the cases, the INR level went up before going down after stopping warfarin. Morphine may be responsible for this trend. Delay in surgery does not seem to increase mortality or morbidity compared to published studies.


CD Thomas MA Bhutta DS Johnson

Introduction: The aim of this study was to assess the practice of obtaining informed consent for Total Hip Replacement Surgery in the United Kingdom.

Methods and results: 1571 consultant members of the BOA were surveyed by postal questionnaire regarding their practice towards obtaining informed consent for total hip replacement surgery. 524 (33.3%) replies were received. 368 (23.4%) of the 524 consultants who replied still performed total hip replacement surgery. In obtaining informed consent for hip replacement surgery consultants warned of the following complications: Infection 99.7%, Dislocation 98.9%, Leg length discrepancy 75.2%, Aseptic loosening 85.8%, neurovascular damage 61.9%, Wear 63.2%, DVT 96.0%, PE 89.0% and Mortality 71.6%. Consent was routinely obtained by Senior House Officers in 38.7%, by Pre-Registration House Officer in 3.8% and by specialist nurses in 5.4% of cases. Patient information leaflets were provided by 72.0% of consultants for Hip Replacement.

Discussion: We recommend national guidelines relating to obtaining consent for hip replacement should be published by the British Hip Society. This should be incorporated into their best practice documents regarding Hip replacement Surgery. Consent should also be obtained by a suitably experienced practitioner.


S Ghosh N Maffulli C Wynn Jones

Introduction: We present here the clinical features and management strategies of patients with gluteus medius and minimus enthesopathy.

Methodology: We studied seven patients with lateral hip pain and tenderness on palpation, worse over the tip of the greater trochanter. All of them had a positive Trendelenburg’s sign, and a transient relief of pain on injecting local anaesthetic in the abductor mechanism. All of these patients were tertiary referrals from the rheumatologists, who had at least once injected them with corticosteroids.

Results: Four of these seven patients underwent exploration. An insertional tendinopathy of the abductors was noted in all the patients, and was debrided. Two of the patients had, in addition, a tear in the gluteus medius tendon, which was repaired. One patient had an injection of local anaesthetic and Aprotinin in the abductor mechanism with resolution of symptoms.

Discussion: Gluteus medius and minimus enthesopathy is a distinct clinical entity. Although the condition has been described in the radiological literature, we were unable to find any reference to the orthopaedic management of this condition. We observed only a small number of patients, and we are thus unable to provide definite answers. Patients presenting with the above clinical features warrant consideration of the diagnosis of abductor enthesopathy. Ultrasound scan or MRI scan helps in confirming the diagnosis. At present, our management protocol involves injecting a local anaesthetic / Aprotinin in the abductor mechanism. However, we are cautious in injecting more than once, as, at operation, we have observed necrosis of the abductor mechanism at its insertion in two patients, similar to that described for Achilles tendon. If this fails, we undetake surgical exploration. The exact surgical procedure is difficult to predict and may involve debridement and repair of the pathological tendon.


SC Budithi PK Mereddy RK Logishetty AVF Nargol

Introduction: The distorted anatomy in Developmental Dysplasia of the Hip (DDH) makes a total hip arthroplasty (THA) a challenging procedure. The purpose of the current study is to report the midterm results after uncemented primary hip arthroplasty using S ROM prosthesis in a prospective series of patients with hip dysplasia.

Methods: We performed 22 uncemented total hip replacements using S ROM prosthesis in 21 (12 female and 9 male) patients with hip dysplasia. The means age at the time of hip surgery was 41.8 (22 to 64) years. The mean follow-up was 6.3 (3.8 to 9.6) years. In 9 (40.9%) patients the operative treatment of DDH was performed during the early childhood (femoral osteotomy in 6 and pelvic osteotomy in 3). All patients were evaluated clinically and radiologically. The femoral head displacement prior to THA surgery was classified according to Crowe at al. classification (4 hips were type1, 2 type2, 10 type3 and 6 type 4).

Results: The average Harris Hip Score improved from 29.48 to 72.76 (44 to 99) and the average Oxford hip score is 31.22 (12 to 47). The range of flexion is 60°–120° (average 83.23) and abduction is 10°–40°(average 22.94). None of the hips has dislocated. Radiolucent lines were noted around the femoral stem in one case. None of the cases have developed osteolysis around femoral prosthesis. In one patient (4.5%), revision hip surgery was done for aseptic loosening of cemented acetabular cup.

Discussion: The midterm results of total hip replacement in DDH using S ROM uncemented prosthesis are promising. We recommend this modular prosthesis for hip replacement in dysplastic hips.


MW Neil G McAlinden

Introduction: In patients presenting with an infected hip arthroplasty first-line antibiotics at our institution are Flucloxacillin and Fucidic Acid. It was observed that many patients needed their antibiotic regime changed once sensitivities became known. This was because of resistance to the first-line antimicrobial agents. This raised the question ‘How frequent is Flucloxacillin and Fucidic acid resistance in prosthetic hip infection and is there a more appropriate first-line antibiotic?’

Method: A computerised search of the Belfast Orthopaedic Information System (BOIS) identified all cases of infected hip arthroplasty from October 2001 to April 2005. All microbiology results of these patients were obtained and analysed to determine the infecting organism, sensitivity and resistance to Flucloxacillin, Fucidic acid and Teicoplanin.

Results: BOIS identified forty cases of infected hip arthroplasty, 35 primary arthroplasties and 5 revision arthroplasties. Of the 40 patients 36 had positive cultures, 3 had no growth and there was missing data on one patient. Flucloxacillin sensitivity occurred in 25% of patients with 58% resistance. With regard to Fucidic Acid sensitivity was 47 % with 44% resistance. There were no cases of Teicoplanin resistance. Teicoplanin sensitivity occurred in 78% of patients and with analysis by organism susceptibility sensitivity would measure 92% (8% were not tested against Teicoplanin).

Discussion: Flucloxacillin resistance is greater than sensitivity in infected hip arthroplasty in this study group. Fucidic Acid sensitivity and resistance are roughly equal. There are no cases of Teicoplanin resistance in our study population and with analysis with respect to the causative organism Teicoplanin sensitivity reaches 92%. It could be suggested therefore that the first-line agents of Flucloxacillin and Fucidic acid are inappropriate and that Teicoplanin may be a better choice.


PMS Simpson AA Smit GF Dall SJ Breusch

Introduction: An intra-medullary cement restrictor is an integral part of modern cementing technique in total hip arthroplasty. Failure of the restrictor to contain cement, flawed surgical technique or dislocation of the restrictor during pressurisation can all result in a deficient cement mantle. A radiographic analysis of hip replacements using a biodegradable restrictor was undertaken to determine the incidence of restrictor failure, the influence of femoral canal morphology on restrictor failure and to describe the cement mantle quality in successful and failed distal cement restriction.

Methods: x-rays from 299 consecutive hip replacements using the amberflex restrictor were analysed. The cortical index, canal-calcar ratio and femoral type, according to Dorr, were recorded. 3 modes of restrictor failure were identified:

Cement leakage –cement was seen to have escaped past the cement restrictor

Restrictor dislocation – the restrictor was 4 or more centimetres distal to the stem tip

Restrictor penetration –the tip of the femoral stem was resting on the restrictor All cement mantles were given a barrack grading.

Results: 84 cases of restrictor failure were observed – 44 dislocations, 24 leakages and 16 penetrations. The mode of failure was not correlated with femoral type, cortical index or canal-calcar ratio. A strong association was found between restrictor failure and grades c and d cement mantles using the chi squared test. A correlation between cortical index, canal-calcar ratio and femoral type was not observed.

Discussion: The ability of a cement restrictor to occlude the femoral canal and resist pressurisation is very important if a good quality cement mantle is to be achieved. Technical error was likely to be an important factor in many of the observed cases of restrictor failure, especially penetrative failure. Surgical technique is more important than femoral morphology in determining the successful use of this restrictor.


J Daniel C Pradhan H Ziaee DJW McMinn

Introduction: Hip resurfacing is a good conservative option for young patients with arthritis. Resurfacings risk two unique failure mechanisms that do not occur in THA, i.e. femoral neck fracture and femoral head collapse.

Old age, osteopaenia, alcohol abuse, and large cysts are risk factors for fractures. It has been suggested that performing a bilateral resurfacing puts the first side at risk of fracture from the force used in implanting the second resurfacing. Is this a true risk or a sampling error?

Methods: Out of 2576 consecutive resurfacings performed by the senior author (July 1997 – May 2005), 191 patients (382 hips, 14.8% of all resurfacings) presented with bilateral arthritis and had both hips operated in the same hospital admission. 133 patients had the two operations a week apart and 58 had both the same day. A posterior approach was used in all cases with the patient in the lateral position on the contralateral side.

Results: Of the 382 resurfacings, only two failed from a femoral neck fracture. Both had the second operation a week after the first. A 35-year lady (rheumatoid arthritis) sustained a femoral neck fracture of the first hip following a fall nine weeks after the operation. A 57-year man (osteoarthritis) fractured his femoral neck at 3.5 months. He fractured the side operated second.

Discussion: The incidence of femoral neck fracture in the author’s series of 2576 resurfacings is 0.4%. Patients who present with bilateral severe arthritis are more likely to have non-primary OA such as inflammatory arthritis. It is difficult to conclude if such bilateral cases are more predisposed to a fracture by virtue of the pathology itself.

The low incidence of fractures (2/382, 0.5%) in this bilateral resurfacing series does not support the view that there is an increased risk of fracture from a bilateral procedure.


MR Downing D Knox GP Ashcroft

Introduction: Dual Energy x-ray absorptiometery (DXA) is a useful tool for the assessment of peri-prosthetic bone mineral changes following total joint replacement. In order to assess these changes the precision of the DXA technique must be optimised. While patient positioning is an important factor, the role of the analysis software should also be considered. We developed and applied a new image analysis method to data from the EXPERT-XL fan beam densitometer (LUNAR GE, USA) aiming to improve reproducibility of bone region and tissue type determination by the analysis software.

Methods: 60 patients with cemented THR received repeat same day DXA examinations. These were initially analysed strictly according to the manufacturer’s femoral peri-prosthetic protocol. A modification of this protocol was attempted allowing further small corrections to the tissue typing by the operator. The scans were then reanalysed using locally developed image analysis to accurately determine the bone, prosthesis and Gruen zone boundaries. The coefficient of variation (CV) was calculated from the differences of the repeat examinations for each of the seven Gruen zones and for the whole peri-prosthetic region.

Results: The average zone CV was 5%. The poorest was zone 1 (10%) and best zone 4 (2%). With the operator corrections there was an overall 4% improvement. With our method there was an overall 40% reduction in variation (average CV 3%, maximum 4%, minimum 2%). The whole region CV was 3.1% for the standard method 2.7% modified and 1.3% for our method.

Discussion: Our method significantly improved the reproducibility of EXPERT analysis. This study demonstrates the high dependency of DXA precision on robust regional analysis.


K Chettiar R Worth L David H Apthorp

Introduction: High-frequency ultrasound is an effective mechanism for coagulating and cutting tissue. We report the first use of the ultrasonic scalpel in orthopaedic surgery, with the aim of minimising blood loss and tissue trauma in minimally invasive total hip replacement.

Methods: This is a prospective, single-blind, case-matched study to compare blood loss in minimally invasive total hip replacement using an ultrasonic scalpel versus electrodiathermy. Twenty cases have been performed via a minimally invasive posterior approach. The treatment was otherwise no different between the two groups. The groups were compared with regard to blood loss, post-operative pain and wound healing.

Results: The mean intra-operative blood loss in the ultrasonic scalpel group was 242mls compared with 319mls in the electrodiathermy group. This is statistically significant (p < 0.05). The percentage drop in Haemoglobin was also reduced in the ultrasonic scalpel group (18.9% compared with 26.4%), which is also statistically significant (P< 0.01). There was no significant difference in the operating time or post-operative pain scores and there were no wound complications in either group.

Discussion: The ultrasonic scalpel works by converting electrical energy into mechanical energy resulting in longitudinal oscillation of the blade at 55,500Hz. This achieves coagulation and tissue dissection at lower temperatures than standard diathermy. The potential advantages include less lateral tissue damage, minimal smoke and no electrical energy passed to or through the patient. With the development of minimally invasive hip replacement surgery this technique can be used to reduce tissue trauma. The initial results from this study suggest that the ultrasonic scalpel has a useful role in minimally invasive hip replacement surgery in terms of reducing blood loss and tissue trauma. This may help to facilitate early mobilisation and reduced hospital stay.


CK Poornachandra S Sharma U Vassan MS Bhamra

Introduction: There has been a renewed interest in metal-on-metal articulation in hip joint Arthroplasty. The reason for having metal-on-metal articulation is to reduce the volume of wear particles that are produced with THR. The outcome of reduced particle formation will hopefully be reduced osteolysis.

Methods: We reviewed the results of 139 primary hip arthroplasties (130 patients) performed using Metasul articulation and cemented Weber cup. Six patients were lost to follow-up leaving 133 hips (124 patients) for review with at least 5-year follow-up. The acetabular socket was the cemented Weber cup and Bone grafting of the acetabulum and application of a reinforcement ring was done where necessary. Cemented CF-30 femoral stem was used in all patients but one (PFMR). The study was conducted retrospectively based on the information collected from hospital notes and Orthocom database. Immediate post-operative films were seen to measure the cup and stem inclination and quality of cementing using the Barracks grading system.

Results: There were 102 females and 22 males in the cohort. Mean age was 73 years (SD-7.46, range 58–86). Left to right hip ratio was 52:81. Most common Pre-operative diagnosis was Osteoarthritis (103) followed by Intracapsular fracture neck of femur (20). The average follow-up was 7.23 years (range 5–10.9). Mean pre-operative Harris hip score was 42.09 and mean post-operative hip scores were 90.01, 86.84, 87.42 and 84.63 at 1-year, 3-year, 5-year and final follow-up with the corresponding pain scores were 42.9, 41.84, 41.56 and 41.56 respectively. Only two hips were revised for aseptic loosening of the cup with a 93.4% implant survivorship at 12 years. There was no case of aseptic stem loosening. No untoward systemic effects were noted in the cohort.

Discussion: We believe that in our study Metasul metal-on-metal articulation has shown satisfactory results with regards to aseptic loosening and reduction in osteolysis in medium-term.


JG Andrew D Beard J Nolan K Tuson D Murray

There has been controversy about whether limb length discrepancy (LLD) affects outcome after total hip replacement (THR). We examined input variables and outcomes of over 1200 patients who received primary THR with the Exeter stem and a variety of acetabular components in the Exeter Primary Outcomes Study. This was a non randomized prospective multi centre study.

We examined whether specific groups of patients or surgeons were more likely to have LLD at one year after surgery. Data for leg length measured on clinical assessment were available for 1207 patients at 1 year. 237 patients were recorded as having a leg length difference of 1 cm or more, and 73 a difference of 2 cm or more. 138 were longer on the operated side and 99 were shorter. The likelihood of having LLD of 2 cm or more was not significantly affected by the grade of surgeon (consultant or trainee), BMI, age of patient, position of patient during surgery or surgical approach, or the use of regional or general anaesthetic.

We examined the effect of LLD on outcomes at 3 months and 1,2,3 and 4 years. Patients with LLD > 1cm had significantly worse Oxford Hip Scores (OHS) at 1, 2, 3 and 4 years (p< 0.01), with the OHS generally being an average 2 points worse in those with LLD. The most consistent difference between those with and without LLD was a patient reported limp on the Oxford Hip Questionnaire.

We conclude that LLD is a common problem after THR and that all patient groups may be affected. It is associated with a significantly worse functional outcome as measured by a validated hip score. Systematic adoption of accurate intra-operative measures of leg length might pay dividends in minimizing this complication.


LK Smith RF Spencer VG Langkamer MN Shannon A J Mahajan JH Dixon R Case

Introduction: NICE guidelines (2000) stipulated three-year follow-up data compatible with satisfactory performance at 10 years as a minimum requirement for hip implants. We reviewed the performance of two devices in use in our department which fell outside these requirements. The Cenator cup (Corin Medical) is a cemented device, and the EPF cup (Plus Orthopedics) is uncemented (equatorially expanded, screw option, polished inside, porous HA coated).

Patients and Methods: 117 Cenator and 110 EPF cups inserted during the period 12/09/2000–28/01/2003 were assessed at 3 years by the following: Oxford Hip Score, satisfaction (visual analogue scale), details of femoral component, age, sex, BMI and any complications. Radiological assessment included Charnley Grade, concentricity, superior cover, cup inclination, migration, radiolucent lines, and linear wear at 3 years. Statistical associations with radiolucent lines or linear wear were calculated.

Results: The mean age of patients with Cenator cups was 81 (range 61–102) and EPF cups 67 (39–86). Oxford Hip Scores averaged 10 (0–41)(Cenator) and 7 (0–29)(EPF). Cup inclination range was 30–65° (mean 47). Linear wear > 1mm was observed in 18 Cenator and 53 EPF cups. Early radiolucent lines behind EPF cups closed (all cases), and superior cover improved in 8%. Progressive radiolucencies > 1mm were seen behind 37 Cenator cups. One of each type was revised for deep sepsis. Four other minor reoperations occurred. Statistical association was demonstrated between superior cover and progressive radiolucencies (Cenator), and between sex, cup size and inclination and linear wear (EPF).

Discussion: Crucial markers of prognosis were observed (progressive radiolucencies and linear wear) but survivorship at three years for aseptic loosening was 100%. Our results indicate satisfactory performance at three years in accordance with NICE guidelines, and suggest acceptability of both devices. Our methods may be applicable to similar implants currently in use but not yet endorsed by suitable published outcome data.


CRW Southgate MJK Bankes

Introduction: Porous Tantalum has been used in a variety of clinical settings since 1997. The use of trabecular metal backed prostheses and augments in the revision hip scenario is attractive due to the higher propensity of bony ingrowth than traditional porous coatings, and also the high coefficient of friction with bone leads to excellent press fit.

We describe the early results of twenty trabecular metal backed acetabular components in the revision setting.

Methods: From 2004, 20 patients received trabecular metal backed acetabular components as a revision hip procedure. The average age of the patients was 69 (42–84) yrs at the time of surgery. 4 patients had trabecular metal shells with cemented liners, 16 patients had modular trabecular metal implants. Structural allograft was used in 2 cases, trabcular metal augment in 1. Revision was for aseptic loosening in 17 cases, infection in 3. Acetabular defects were graded according to Paprosky as 2A(10), 2B(1), 2C(1), 3A(6) and 3B(2).

Fixation was augmented in all cups with at least one screw.

Patients were evaluated with standard x-rays for osteolysis and migration, Harris hip score, SF 36 and Oxford hip score.

Results: Average follow up was 12 months (24–5). 100% follow up was achieved. There were no complications directly related to the acetabular surgery.

There were no revisions. There are no progressive radiolucencies or detectable migration in any of the cups. There were no dislocations.

Conclusion: These early results suggest that trabecular metal backed acetabular components may be confidently used in the setting of hip revision surgery and show promise for the more severe defects for which a reliably reproducible solution has yet to be proven.


AP Kadakia VG Langkamer

The treatment of undisplaced femoral neck fracture in the elderly population is still controversial. We analyzed the outcome of cancellous screw fixation for undisplaced femoral neck fracture in patients over 70 years.

Materials and methods: From 1998 to 2003, ninety-seven patients with undisplaced femoral neck fracture, aged over 70 and treated with cancellous screw fixation were retrospectively identified. Full clinical data was available for 79 of the 97 patients identified. All patients had in-situ fracture fixation.

Results: Of the 79 patients, M:F was 22:57, average age was 81.3 years. The average inpatient stay was 13.2 days. The mean follow up was 12 months (1m–78m). 24 patients had Garden type I and 55 type II fractures.

26 (32.9%) patients did not return to their pre-morbid mobility status, 5 (6.3%) of which did not return to their preadmission dwelling (2 went to residential home and 3 went to nursing home).

We had documented radiographic details in 46 patients: 41 patients had a healed fracture on radiographs (89.1%), 4 patients had AVN, 4 patients had non-union and 1 patient had AVN with non-union. The failure rate was 19.6%. 15 patients had evidence of screw back out with healed fracture.

12 out of the 46 complained of pain postoperatively of which 9 (19.6%) patients had re-operation: 6 (13%) underwent revision surgery and 3 (6.5%) required screw removal.

30-day mortality was 3.7%. 1-year mortality was 23.2% of which 16 died within the first 6 months (19.5%).

Conclusion: This study shows that in our unit, cancellous screw fixation of undisplaced femoral neck fractures in patients over the age 70 has a good outcome with 19.6% re-operation rate. Radiographic failure rate is 19.6%. One third of the patients did not return to their preadmission mobility level/dwelling.


MHA Malik F Wadia ML Porter

Total hip replacement is a successful and reliable procedure for the relief of pain, but the results achieved have been reported to be less successful in younger patients who tend to be relatively more active and place greater demands on prostheses than older patients.

Between 1966 and 1978, 226 Charnley low friction arthroplasties (LFAs) were implanted in young patients with an average age at operation of 31.7 years. Initial results were presented at an average of 19.7 years. We have performed a further retrospective analysis of this cohort at 10 years on from the time of data collection of the original study. Of the original cohort, 112 patients are alive and either under follow-up at our hospital or have been traced to other hospitals. 16 have been lost to follow-up. Mean follow-up was 26.4 years. At the time of final follow-up or death, rate of aseptic loosening of the stem was approximately 80%. Acetabular components proved to be less successful with less than 60% remaining well fixed. Differences in survival were apparent between subgroups with differing original pathology with stem survival greater in those with DDH as opposed to rheumatoid or degenerative arthritis and the opposite being true for socket survival.

This study adds to the available knowledge of the longevity of cemented total hip replacement as performed with unsophisticated cementation techniques and how it may perform in differing patients groups.


KM Venu Y Inaba LD Dorr Z Wan L Sirianni M Boutary

Introduction: Technical and patient care improvements have occurred with the posterior mini-incision total hip replacement (THR). The hypothesis of this study was that these changes would provide better results for patients in the posterior mini incision surgery (MIS) THRs performed in our institution.

Methods: The clinical and radiographic results of 100 THRs performed with the posterior mini incision between January 2004 and October 2004 were compared with 100 mini incision THRs performed between December 2001 and September 2002. The second group was subjected to improved operative technique, the post-operative analgesia protocol, rehabilitation and patient advise. The acetabular cup abduction angle, anteversion angle, and stem varus/valgus alignment angle were measured in the post-operative radiographs in both groups. Pain score and Harris hip score were recorded at 6 weeks and 3 months. Statistical analysis was performed using Student 2-tailed t test, Chi-squared test and Wilcoxon-Mann-Whitney tests to compare the incision length, operative time, estimated blood loss, length of hospital stay, pain score and radiographic measurements between the two groups.

Results: The results showed that the component positions were not compromised in either group. There were statistical improvements in 2004 group with less estimated blood loss, decreased hospital stay, reduction of postoperative pain and opioid analgesic use and earlier muscle recovery. In 2004 group there were no complications of infection, dislocation, or sciatic palsy.

Discussion: The posterior mini-incision operation has shown improved results with experience and changes in technique and patient care treatment. We have continued our practice using this new technique.


H Nagai PR Kay BM Wroblewski

Introduction: Bone stock and cement-bone interface in revision total hip replacement (THR) for deep infection have never been investigated in the literature, while they are known to be important for aseptic loosening. The purpose of this study was to assess preoperative bone stock and immediate postoperative cement-bone interface as factors affecting infection control and mechanical outcome after revision THR for deep infection.

Methods: This study included 115 cases in which revision THR with antibiotic-loaded cement was operated for infected hip replacement by a single surgeon with minimal follow-up of five years (range 5–27 years). Preoperative bone stock was classified into four grades (Grade 0: No bone loss, Grade 1: Demarcation, Grade 2: Localized cavitation, Grade 3: Extensive bone loss). The immediate postoperative cement-bone interface was also graded into four categories (Grade A: White-out, obscure interface, Grade B: Clear line, no measurable gap, Grade C: Gap> 1mm, Grade D< 1mm). These two factors were analysed with regard to infection control and mechanical survival of implants after surgery.

Results: Bone stock did not have significant influence on infection control while it affected mechanical outcome. The cement-bone interface was an affecting factor for not only the mechanical survival of implants but also the cure of infection.

Discussion: There was a good chance of curing the infection even with extensive bone loss. Good cement fixation was an important factor with regard to infection control as well as the mechanical survival of implants. The results suggested that it might be important to shield the medullary space from the infected joint space with antibiotic-loaded cement.


M Revell I Stockley S Davies P Norman

Introduction: The correct identification of the infecting micro-organism in prosthetic joint infections is difficult and there is no single method that is wholly reliable. We report a novel method intended to improve accuracy by disrupting the biofilm surrounding the prosthesis and transferring samples rapidly to culture medium.

Method: Explanted prostheses from 20 revision operations were sampled by pressing a microbiology swab or by passing a No.10 surgical blade along it. The sample so obtained was plated immediately in the operating theatre onto horse-agar petri dishes. These were incubated in aerobic conditions in the laboratory. Culture results were compared with those obtained from our standard detection method using multiple tissue samples with are plated or grown in prolonged aerobic and anaerobic culture broth.

Results: The method proved practical to perform in practice. When compared with multiple tissue samples as the standard, the Positive Predictive Value was 90%, Negative Predictive Value 80%, sensitivity 82%, specificity 89%. In 4 of the 10 true positive samples, the theatre-inoculated samples yielded early results within 3 days, while conventional method yielded positives only later on prolonged culture.

Discussion: The above pilot is to continue and has started to alter our practice in sample taking. Blade-scrape does appear to penetrate the biofilm successfully. Growing confidence in interpretation and ease in reading the plates mean that in certain cases, we consider the results to be more reliable than traditional tissue culture. Direct plating also reduces the chance of bacterial overgrowth in broth inhibiting colonies of secondary infective organisms. Further refinement is needed, particularly with regard to anaerobic bacteria. Inaccuracies have resulted when agar plates are allowed to go out of date.


D Prakash J N de Beer T Khan J H Kilbey M Firth

Introduction: The anterior and anterolateral approach to the hip traditionally are well described exposures in primary hip arthroplasty with fewer dislocations than the posterior approach. A very debilitating complication associated with the anterolateral approach however is the persistent limp and positive Trendelenburg sign. We discuss our results with respect to abductor function and morphological integrity seen on MRI when using an approach in which we preserve the majority of gluteus medius.

Methods: We carried out a prospective study of thirty-nine consecutive total hip replacements performed through a gluteus medius sparing anterolateral approach. The same hip surgeon performed all these between April and October 2004. Gait analysis and Trendelenburg tests were evaluated during clinical follow-up at six weeks and three months. Coronal STIR and T1 weighted MRI sequences of the abductors were performed between four and six weeks and the findings were agreed by the consensus of two radiologists.

Results: At three-month follow-up all thirty-nine patients tested Trendelenburg negative. Post-operative radiographs showed satisfactory femoral and acetabular component position. MRI findings showed the gluteus medius tendon to be intact with no shortening on T1. Artefacts were found to be less marked in the higher field strength magnet but more apparent in the STIR weighted sequences.

Discussion: We have tried to incorporate the advantages of reduced dislocation rate of the anterolateral approach, whilst avoiding violation of the abductors. The clinical result and radiographic findings we have presented suggest that the described exposure is an effective and safe method of approaching the hip, with minimal disruption of the abductor mechanism. In addition to maintaining the reduced dislocation rate associated with the standard anterolateral approach. Intact abductor function allows for rapid rehabilitation.


WJ Hart JP Hodgkinson

Introduction: Revision hip arthroplasty places a significant burden on hospital resources. Huge pressure is being placed on the orthopaedic community to alter practices with respect to implant selection and bearing surfaces in order to try to reduce the likelihood of revision due to aseptic socket loosening. To date there is little clinical evidence to support these changes.

Aim: To review the case mix requiring revision surgery at a specialist arthroplasty unit in order to identify the common reasons for failure of primary arthroplasties.

Methods: A retrospective single surgeon review was performed to identify patients who had undergone revision hip surgery over the study period. The reasons for revision were identified for all cases. Particular attention was paid to the cases with aseptic socket loosening to determine the time to revision for these cases.

Results: 176 revision procedures were performed between October 2001 and May 2005. In 74 (42%) cases aseptic socket loosening was identified (average socket survival 15.4 years). In 16 cases this was the sole cause for revision. In 58 cases the femoral component was also loose. 102 (58%) cases were performed for other reasons. Dislocation was the cause in 14%, femoral component loosening in 20%, infection in 18% and fracture in 6%. Aseptic loosening of cemented sockets less than 10 years old was only seen in 7 (4%) cases.

Conclusions: Aseptic loosening of cemented sockets less than 10 years old was the least common cause of revision in this series. Cemented polyethylene acetabular components continue to provide a satisfactory bearing surface on the acetabular side of total hip arthroplasties. We recommend caution when interpreting the information provided with new products with respect to the benefits of different fixation and bearing surfaces for the majority of patients.


M Venkatesan SN Sambandam R Burman S Maxfield RC McGivney B Ilango

Introduction: Infection following THR is a catastrophic complication. Few authors have highlighted the need for screening of patients (nose, axilla and groin) before THR. Despite the fact that some of the centres in UK now routinely perform preoperative screening for THR patients the overall incidence of surgical site infection in the year 2004 was 2.9%.

Methods and Materials: We introduced a new admission policy and SSI surveillance protocol for THR patients in the year 2004 at our centre. According to the new admission policy all THR patients who were preoperatively screened were admitted into a clean elective ward. Care was taken not to admit anybody with positive infection screening in that ward, irrespective of the diagnosis. Further we also introduced a new policy of SSI surveillance according to NINSS protocol carried out by dedicated trained nurses.

Results and conclusions: Following the introduction of these policies our surgical site infection has come down to 0% in the year 2004–5 in contrast to 1.7% in the year 2002–3. These results showed that simple measures like having dedicated infection free clean wards and dedicated trained surveillance nurses can significantly reduce the infection rate following THR.


M Venkatesan V Ramasamy SN Sambandam B Ilango

Introduction: Outcome reporting following THR constitute a significant proportion of orthopaedic publications. Publication bias in the form of underreporting of studies showing non satisfactory or negative results is a well recognised problem in other specialities. We tried to find out the magnitude of this problem in orthopaedics publications dealing with THR.

Method and materials: We reviewed all publications on THR in the year 2004 in three general orthopaedic journals namely JBJS (BR), JBJS (Am), CORR. Of the 1034 original articles published in these three journals more than 400 articles were concerned with total hip replacement.

Results and Discussion: In this study we found only 6% of the published articles were showing non significant or negative results. This raises concerns about evidence based approach in THR and the need for preventive measures like registering all clinical trials and change in the attitude of editorial board.


A Gordon AJ Hamer I Stockley R Eastell JM Wilkinson

Introduction: Activated peri-prosthetic macrophages release pro-inflammatory cytokines, including interleukin-6 (IL-6), that stimulate osteoclast activation and aseptic loosening. Natural sequence variations (polymorphisms) within the IL-6 gene promoter region are associated with diseases characterised by increased osteoclast activity, including osteoporosis, and affect IL-6 production in-vitro. We tested whether polymorphisms in the IL-6 gene promoter influence the risk of aseptic loosening after total hip arthroplasty (THA).

Methods: 614 Caucasians, 292 men and 322 women, mean age 75.8 years who had undergone primary cemented THA for idiopathic osteoarthritis a mean of 13.4 years previously were recruited. Peripheral blood was taken and DNA extracted using standard techniques. Subjects were genotyped for the IL-6 -174, -572, and -597 promoter single nucleotide polymorphisms using the Taqman 5′ nuclease method.

Results: The allele frequencies and carriage rates for both alleles at promoter positions −174, −572, and −597 were similar between controls and aseptic loosening subjects (Table, χ2 P> 0.05 all comparisons).

Discussion: Although Il-6 has been implicated in the pathogenesis of aseptic loosening and the −174, −572, and −597 polymorphisms are associated with bone loosing pathologies, they do not appear to play a major role in aseptic loosening after THA.


N Kharwadkar S Butt AP Walker

Introduction: Osseointegration is known to occur around the uncemented acetabular cups which results in fill-in of peri-acetabular gaps. The objective of this study was to assess the gaps around uncemented acetabular cups radiologically in early post-operative period.

Methods: 53 primary uncemented total hip arthroplasties were performed at our hospital by a single surgeon between February 2003 and august 2005. There were 29 females and 22 males. Two patients had bilateral surgeries. Mean age of patients was 70 years (range, 52–88 years). Primary osteoarthritis of the hip was the indication for surgery in all the patients. Peri-acetabular gaps were measured on the radiographs taken at day-1 post-operatively and at 3 months follow-up. All the measurements were taken independently by two investigators on two different occasions using a picture archiving & communications (PACS) system. The two sets of data from each investigator were compared for intra and inter-observer variability using independent-samples t test.

Results: in 24 cases, no gaps were found around the ace-tabular cups on day-1 post-operative radiographs. In 29 cases, the mean gap was 4 mm (range, 1–8 mm) on postoperative day-1. Five gaps were in zone one, 24 in zone two and none in zone three. At 3 months follow-up, the mean gap was found to be 0.6 mm (range, 0–3 mm). The reduction in gaps from day-1 post-op to 3 months follow-up was statistically significant (chi square test, p< 0.05).

Discussion: We found a significant reduction in peri-acetabular gaps as early as at 3 months following uncemented total hip arthroplasties. We feel that settling of the cup within the acetabulum is responsible, rather than osseointegration, for these fill-in of gaps in early postoperative period. A larger study is required to analyse this phenomenon as screws fixation of uncemented cups may compromise their settling within the acetabulum.


B Derbyshire ML Porter

Introduction: Some reports have suggested an unacceptable failure rate of Elite Plus stem in the medium term. We have previously argued that other measurements must be made in addition to RSA in order to assess reasons for abnormal migrations. This 3-year RSA study of Elite Plus stems assessed the migration pattern and factors that influenced it.

Method: Twenty five patients (23 OA, 2 RA, mean age 60.4 years (37–81)) underwent Elite Plus THR (single surgeon). A-P radiographs were assessed for cementing technique, and measurements (canal widths, stem orientation, cement thickness etc) were taken using CAD software. Activity score and BMI were also recorded. Multiple factors were assessed for correlation with the main components of migration.

Results: One patient’s stem centroid migrated proximally (due to valgus rotation about the shoulder) and the mean subsidence of the others was 0.297 mm at 36 months. Mean internal rotation and posterior head migration (25 patients) at that time were: 1.42° (CI: 0.99° to 1.86°) and 0.801 mm (CI: 0.526 mm to 1.076 mm), neither being significantly different from migrations at 24 months. One patient’s stem migrated continuously. By 36 months, it had subsided 1.279 mm and internally rotated 4.2°. Some significant correlations (p < 0.05, rho > 0.6) were 3M and 36M subsidence with proximal-medial cement thickness; effective offset with 36M medial migration.

Discussion: The one patient with continuous high migration had the highest activity level. This was corroborated by a wear measurement of 3.5 mm in the contralateral (Charnley) hip which had been in place for 9 years (assuming the head was not scratched). If RSA, 3 years postoperatively, can predict future outcome, the 4% failure rate is similar to the ten year results of the Charnley hip.


DM Wright A Alonso E Lekka DH Sochart

Introduction: Fractures of the femoral stem component in total hip Arthroplasty have been a well documented complication. The incidence over recent years has decreased due to improvements in surgical technique and implant design and manufacture.

Methods/Results: We report two cases of femoral stem fracture. Both occurred in CDH stems from the C-stem system (Depuy International, Leeds, UK). These are the first reported fractures in this stem. Both patients were women weighing 83kgs and 98kgs at the time of fracture giving them BMI’s of 31 and 41 respectively. In both cases the BMI had increased since the time of operation.

Discussion: The design of the CDH stem is fundamentally different from the rest of the standard stems with absence of the medial strut. In addition to this factor, both stems fractured through the insertion hole which acted as a stress raiser. Finally both patients BMI’s were above 25. At the time of operation no weight limit was imposed on this prosthesis.

We conclude that if possible, a standard C-stem should be inserted but if a CDH stem is used attention to patients’ weight is paramount.


AJ Hart T Hester A Goodship JJ Powell L Pele NL Fersht JA Skinner

Introduction: There have been 70,000 hip resurfacings implanted, predictions are for it to become 12% of the US hip replacement market by 2010 (Goldmann Sachs report Oct 2005). There is concern that the cobalt and chromium ions released from metal on polyethylene hip replacements cause immune dysfunction in the form of T cell mediated hypersensitivity (indicated by increased numbers and stimulation of T cells). If metal ions cause significant effects on white blood cells we might reasonably expect to detect this by simply measuring numbers of white blood cells.

Aim : To examine the possibility that raised metal ions may cause an abnormal number of white blood cells, termed a blood dyscrasia.

Method : Peripheral blood samples were analysed from 68 patients: 34 in the hip resurfacing group and 34 in the standard hip arthroplasty group. Samples were analysed for counts of each sub-group of lymphocyte. Functional assessment was also performed using a activation panel of white cell CD markers. Whole blood cobalt and chromium ion levels were measured using inductively-coupled mass spectrometry. All hip components were well fixed.

Results : Cobalt and chromium levels were significantly elevated in the resurfacing group compared to the hybrid group (p< 0.001). There was a statistically significant decrease in the resurfacing groups’ level of CD8+ cells (T cytotoxic/suppressor) (p=0.010). There was a characteristic pattern of immune modulation seen on the activation panel.

Conclusions : We found an immune modulation in patients with metal on metal hip resurfacing. This was not a hypersensitivity reaction. This change in T cell function may be detrimental or beneficial to patients.


JG Andrew D Beard J Nolan K Tuson D Murray

The optimal surgical approach for total hip replacement (THR) remains controversial. We report the clinical outcomes of over 1000 patients in the Exeter primary outcomes study (epos) who underwent primary THR with a cemented Exeter stem (Stryker) but with various acetabular components. This was a prospective non randomised multi centre study. Patient reported hip scores (oxford hip score (OHS)) were measured before operation and at 3 months (n= 1312), 1 (n=1276), 2 (n= 1225), 3 (n=1205) and 4 (n=975) years post operatively. Physician reported scores (Merle d’Aubigne / Postel, MDAP) were measured before operation and at 12 months. All of the operations were carried out using either the anterolateral (Hardinge or modification) or posterior approach.

The posterior approach gave better absolute OHS scores at 3 months and 1 year compared with the anterolateral approach. The improvement in OHS between the pre-op and relevant post-op score was better for the posterior than the Hardinge approach, and this extended to 4 years (all p< 0.05). Early dislocation rates were low in both groups. There was significantly more likely to be heterotopic ossification in the Hardinge group, while stem alignment into varus was more common in the posterior approach group. There was no significant difference between the two approaches as measured using the MDAP score at pre-op or at 12 months after surgery.

These results demonstrate that initial patient perceived clinical benefit of surgery is greater using a posterior than with an anterolateral approach. This should be considered when assessing the best approach for a particular patient. The current results emphasise the value of using patient based outcome measures, as the MDAP score did not detect a difference in outcomes between the two groups.


B Komarasamy R Vadivelu CJ Kershaw JN Davison THA Minhas

Introduction: Tantalum Monoblock Acetabular cup was designed to reduce backside wear and stimulate osseo-integration of cup with bone. The cup has peripheral fit to improve the initial stability and further stability and longevity depends on the osseointegration of cup with acetabulum. The revision cup was intended to give added stability with screws in case of defective rim or large acetabulum. The aim of this study is to assess the radiological outcome following tantalum monoblock revision cup in total hip replacement.

Methods: Between 1999 and 2000, 32 Tantalum mono-block revision acetabular cups was used in 31 patients. Standard hip radiographs were performed during post op, at three months, six months and then annually. X rays were assessed for loosening in De Lee and Charnley zones and for migration of cup.

Results: At a minimum follow-up of 2 years (range 2 to 5 years), 31 hips in 30 patients were assessed. The average age of the patient was 62.4 years (39–78 years). Three Brookers type 1 and one type 2 heterotrophic ossification was seen. There was a gap of 2–5mm in Zone 1(6 patients), 1–5mm in Zone 2 (8 Patients) and 5mm in Zone 3 of one patient. At final follow up, all the gaps were filled, except for one, where 5mm gap was persistent. There was no migration of cup or problems with screws. All the patients were satisfied with the operation.

Conclusion: Short term radiological result following uncemented revision tantalum monoblock acetabular cup in total hip replacement is highly encouraging. However, similar results from other centres and long term follow up studies are necessary to confirm the efficacy of the revision cups.


B Komarasamy R Vadivelu CJ Kershaw

Background: Internal snapping often resolves with conservative treatment but persistent significant symptoms may require surgical treatment. Different approaches and treatments have been suggested in the literature with weakness of hip flexion, recurrence of symptoms and nerve injury following surgery. We describe a modified surgical approach for internal snapping of hip in adults with good results.

Methods: Patients who failed conservative treatment for internal snapping between September 02 to February 04 were included. All patients had x-rays of relevant hips; ultrasound and MRI were done when required to exclude other causes. Patients were operated in supine position. A skin crease incision was made just lateral to the ASIS. The psoas tendon was reached sub-periosteally along the internal iliac surface hooked into the wound and divided releasing its musculo-tendonous junction. The patients were allowed to mobilise as able in the postoperative period.

Results: There were 8 snapping hips (3 right, 3 left, 1 bilateral) in 7 patients (6 females, 1 male) with average age of 30 years (17–51 yrs). The mean follow was 11 months. The average duration of symptoms before operation was 4.5 years (range 2–10 years). Clicking was relieved in all patients. Two patients felt slight weakness of hip flexion. One patient had temporary neuropraxia of lateral cutaneous nerve of thigh.

Discussion: The diagnosis is made by ultrasound or examination for a palpable click. Surgical correction of snapping is considered after failure of conservative treatment. Different extra pelvic (medial and iliofemoral) and intrapelvic extraperitoneal approaches have been described with varying results. With our slightly modified intrapelvic and sub-periosteal approach through oblique inguinal incision in adults, psoas muscle release at musculo-tendonous junction seems safe and effective (all clicking resolved) method. This method could be used as an alternative surgical approach for treatment of internal snapping of hip in adults.


M Bhattacharyya M Mostert D Condon

Background: The use of psoas compartment block provides good analgesia but poor surgical anaesthesia. In Ortho-geriatric care different nerve blockade had been used to avoid the systemic adverse effect of centrally acting agents and provide long duration of unilateral limb analgesia after arthroplasty.

Aim: The aim of the study is to establish the quality of pain control, incidence of side effects and complications achieved with a psoas compartment block (PCB) following surgery for fractured neck of femur.

Study design: Prospective, Non randomised, longitudinal, Cohort. A Pilot Study period January 2003 -December 2004

Materials & Method: 10 patients of mean age 74.8 years (Range 23–93), 3 males and 9 females had unilateral hip surgery with general or a spinal (with no intrathecal opiate administration) as the main anaesthesia and a psoas Compartment Block for continuous infusion of bupivacaine for postoperative pain control (a total dose of 2mg/kg given in theatre and received a continuous infusion of bupivacaine 0.1% at a rate of 25ml/hour for 48 hours) and assessed by nurse led pain team.

Result & analysis: All the patients in this study group had excellent pain control. On the first post operative day only one patient had mild pain, and another had moderate pain. On the second day 3 patients had mild pain [chart 1].

Conclusion: These patients had excellent to good post operative pain control without having any adverse side effects. This study will help us to treat pain among elderly geriatric patients particularly in the demented group in immediate post-operative period. We need randomised comparative study to advocate this practice.


MW Neil SG Neil

Introduction: The curing of polymethylmethacrylate cement is an exothermic reaction, with temperatures reaching 80oC. Thus contact with cement can result in thermal injury. During orthopaedic procedures bone cement may be inadvertently left lying on surgical drapes. This study aims to investigate the effect of drapes on the contact temperature of such cement.

Methods: The experiment was carried out in an orthopaedic theatre with a constant temperature and humidity. Polymethylmethacrylate cement was prepared and pieces of cement of a specific size were investigated. Experiment one measured the contact temperature of curing cement in isolation. Experiment two and three investigated the effect of one and two layers of surgical drape respectively on contact temperature.

Results: The mean maximum temperature reached in experiments one, two and three was 75oC, 71oC and 69oC respectively. The maximum temperature was reached quickest in experiment three. In considering the time period that the contact temperature remained above 40oC this was longest in experiment three at 750s followed by experiment 2 and then experiment 1 at 525s and 330s respectively. Contact temperature graphs for each experiment have been plotted in figure.1

Discussion: One might think that drapes provide a protective barrier between a patient’s skin and bone cement, however this is incorrect. The drapes insulate the exothermic reaction of curing bone cement which tends to accelerate the reaction. Furthermore the insulating effect of drapes causes curing bone cement to lose heat at a slower rate resulting in the contact temperature remaining above 40oC for longer; this increases the potential for thermal injury. This study demonstrates that a specific effort should be made to ensure bone cement is not inadvertently left lying on surgical drapes.


DJ Matthews P Moonot AMH Latif MD Cronin J Riordan RE Field

Introduction: Measurement of outcome after THR is becoming increasingly important. NICE guidelines have been established and ODEP have stipulated target criteria for the successful evaluation of novel implants. To date, a streamlined, efficient Outcome Programme has not been developed which satisfies the required follow-up criteria. A Programme has been developed at our unit and its evolution is reported.

Methods: A database was created with the assistance of a database developer and an “Outcome Co-ordinator” was appointed to operate the database and manage the programme.

Operation data is now entered onto the database by the surgeon or co-ordinator at the time of surgery. Thereafter, the database automatically produces annual Oxford Hip Questionnaires, EQ-5D questionnaires and invite letters to patients for clinical review at stipulated time-points.

Questionnaires are returned by patients and scanned. This data is then electronically imported to the database without transcription error. Patients attend special Outcome clinics, staffed by Research Fellows and SpR’s, who examine the relevant hip and review their radiographs. The findings are recorded and the paper forms scanned and imported into the database. Non-responders are identified from the database and are chased up via telephone by the coordinator.

Data is extracted from the database with queries and presented using database reports.

Results: 2455 THR’s have been recorded on the database (2127 primaries, 328 revisions) 1937 patients continue under active review for THR. The percentage of patients lost to follow-up is only 2%, 10%, 15% at 2, 5 and 10 years respectively.

Discussion: An efficient system has been developed to maximise the follow-up of patients post THR. The burden on outpatient clinics is reduced and meaningful outcome measures are obtained. The programme could easily be extended to other centres throughout the UK and the benchmarks set by ODEP and NICE can also be attained.


J Daniel C Pradhan A Salama H Ziaee DJW McMinn

Introduction: The increasing use of metal-metal bearings in hip arthroplasty raises concerns of elevated systemic metal levels. Lubrication theory and in-vitro studies suggest that larger diameter bearings generate less wear. Does this hold true in real life?

Methods: This is a cross-sectional study of 181 patients with either a Birmingham Hip Resurfacing or a 28mm Metasul THR. Whole blood levels (at 1year) and urinary metal ion output in the early (1 to 3) years and medium term (4 to 6years) in patients with these bearings were compared. None of the patients had other metal devices or compromised renal function. Both devices used a high-carbon cobalt-chrome bearing with no post-casting heat treatment. Cementless porous-ingrowth titanium cups and cemented polished tapered stainless steel stems or cementless porous-ingrowth titanium alloy stems were used in THRs.

Results: Whole blood metal levels at 1-year and daily output of metal ions in the early years and medium term (figure 1) in both bearings were in the same range and without a significant difference.

Discussion: Metal ion monitoring is the best way to estimate bearing wear in vivo and the best measure of device safety in the long term. Total wear over a given time period is best estimated from timed metal ion excretion rates. Blood levels represent a balance between the release of metal from the device and its renal clearance.

An earlier study (Clarke et al JBJS(Br) 2003) suggests that smaller bearings generate less wear. In that study bearings with different metallurgy and wear properties were grouped together, a potential confounding factor. The present study does not suffer from that error and our findings do not support the view that a larger bearing diameter leads to either an increase or decrease in metal ion generation.


J Daniel C Pradhan H Ziaee PB Pynsent DJW McMinn

Introduction. Painful post-collapse femoral head osteonecrosis (AVN) continues to be a therapeutic challenge. Joint preserving surgery does not produce satisfactory results after femoral head collapse, making an arthroplasty almost inevitable. Does metal-metal resurfacing offer a conservative option that matches the consistent results of a stemmed THA in these patients?

Methods. 104 consecutive resurfacings (94 patients) performed for Ficat stage III/IV AVN were reviewed clinically, radiologically and with Oxford hip scores. Mean age at operation was 43.9 years. Aetiology included trauma (20%), steroids/chemotherapy (25%), alcohol abuse (8%), AVN secondary to Perthes’/SUFE (4%) and idiopathic (43%). Two types of devices were used a) McMinn Resurfacing Arthroplasty, HA-coated smooth uncemented cup and cemented femoral component and b) Birmingham Hip Resurfacing, porous HA cup and cemented femoral component.

Results. At 2 to 11.5 years (mean 7.7 years), there were seven (6.7%) failures: four from further femoral head collapse, two infections and one osteolysis, aseptic loosening. The cumulative survival at 11years is 90% (figure 1). Mean Oxford score at follow-up is 15.4. 55% participate in moderate to heavy work or participate in regular sporting activity.

Discussion. The results of any treatment modality in AVN are not as good as those in osteoarthritis. One reason is that the etiopathological factors that caused non-traumatic AVN (steroids etc) have the potential to cause continued femoral head damage. Post-traumatic patients need complex reconstructions and risk a higher failure rate. Those on immunosuppressants are prone to infections. The results of hip resurfacing in AVN in this series are no different from THRs in many published series. Metal-metal resurfacing is a good conservative option for post-collapse femoral head AVN and gives acceptable results if strict patient selection criteria are followed.


CY Ng JA Ballantyne IJ Brenkel

Introduction: SF-36 is a validated 36-item questionnaire that measures eight dimensions of quality of life(QoL): physical functioning(PF), role physical(RP), role emotional(RE), social functioning(SF), mental health(MH), energy/vitality(EV), bodily pain(Pain) and general health perception(GHP). The primary aim of the study was to evaluate QoL outcomes after total hip replacement(THR) using SF-36.

Methods: From 5/1/1998 until 16/8/2005, we prospectively collected data on 569 patients who had THR in Fife. 30 of them had bilateral THR. Each patient was assessed pre-operatively and was reviewed at 6 months, 18 months, 3 years and 5 years post-operatively. A SF-36 was filled in at each appointment.

Results: During the period, 6 patients died, 4 had revision, 19 were lost to follow-up and 46 did not attend their 5-year review. Subsequently, 494 patients had a 5-year review but 46 of them did not fill in the questionnaire. Analysis was performed on the remaining 448 patients (male=179, female=269).

Mean scores of PF, RP, RE, SF, EV and Pain improved significantly following THR. The improvement remained significant throughout the follow-up (p< 0.0005). MH was the only dimension which did not change significantly after THR. There was a significant decline in GHP (p< 0.0005).

Females reported lower scores in all dimensions apart from GHP. They were also significantly older than the males (66.66±9.41 vs. 64.69±10.27 years; p< 0.037).

Patients who had unilateral or bilateral THR reported similar scores preoperatively and in the initial follow-up. Significant differences were only noted at 3 and 5 years with the bilateral group reported a higher score.

Discussion: THR improved QoL and the benefit was still evident at 5 years post-operatively. However the perception of general health continued to deteriorate, probably due to the effects of aging. More advanced age of females might partly contribute to their lower scores.


TA Bucher I Okpala E Aziz MJK Bankes

Introduction: The treatment of end stage hip osteonecrosis in patients with Sickle cell disease presents a unique set of challenges, with patients often needing arthroplasty in young adult life. Traditionally, this group of patients has a high incidence of complications and failure. We report the early results of THR in patients managed by the single hip surgeon working as part of the comprehensive Sickle Cell service.

Methods: Data was collected prospectively on all sickle patients undergoing THR at our institution. 18 patients underwent surgery with a mean age of 37 (range 25–63). There were 16 primary and 2 revisions. All patients were optimised pre-operatively with an exchange transfusion to ensure the HB SS < 30%, and all possible sites of sepsis were treated aggressively. All patients received uncemented implants with hard on hard bearings and broad-spectrum prophylactic intravenous antibiotics for 48 hours.

Results: 18 patients were followed up at a mean of 25 months. Despite technical challenges, all patients had a stable hip with good resolution of pain and radiographic evidence of bony ingrowth of all components. There were 3 minor intra-operative metaphyseal peri-prosthetic fractures, which all healed satisfactorily. There was a single early dislocation that has remained stable after closed reduction. There have been no superficial or deep infections.

Discussion: This study shows that THR can be performed safely in patients with sickle cell disease within the context of a multi-disciplinary team approach. Operative technique involves the use of long drills under image intensifier to prepare the femur safely and use of a modular uncemented system to address the mismatch between the metaphysis and the diaphysis.


ET Davis P Gallie JP Waddell EH Schemitsch

Introduction: When performing a hip resurfacing procedure through the postero-lateral approach, concern has been expressed as to the proximity of the femoral neurovascular bundle during the anterior capsulotomy. We aimed to identify the proximity of the femoral nerve, artery and vein during an anterior capsulotomy.

Methods: 5 fresh frozen cadaveric limbs were used. A standard postero-lateral approach was performed. An anterior incision was then made to identify the femoral neurovascular bundle. Measurements were taken prior to hip dislocation. The femoral head was dislocated, capsulotomy scissors were inserted though the posterior incision and positioned to cut the superior and then inferior aspects of the anterior capsule. The distance from the scissors to each of the neurovascular structures were recorded. Measurements were made with the hip in flexion and extension.

Results: Prior to dislocation the mean distance from the capsule was 25mm for the femoral nerve, 21mm for the artery and 21mm for the vein. Following dislocation, with the hip in extension the distance during cutting of the antero-superior capsule to the nerve, artery and vein was 31mm. With the hip in a flexed position, the distance from all three neurovascular structures increased by a mean of 5mm. When the scissors were positioned to cut the antero-inferior capsule in extension, the mean distances to the nerve, artery and vein were 31mm, 28mm and 28mm. When the hip was flexed, the distance to the nerve decreased by 2mm.

Discussion: Our study suggests that the neurovascular structures are relatively well protected during an anterior capsulotomy performed during hip resurfacing. The procedure may be safer if the capsulotomy is performed with the hip dislocated and the hip in a flexed position while cutting the antero-superior aspect and in an extended position while cutting the antero-inferior aspect.


UT Vassan S Sharma P Choudary MS Bhamra

Introduction: Aseptic loosening is the major cause of implant failure. In cemented hip Arthroplasty it is well known that the acetabular side fails earlier due to lysis caused by wear particles. This is the rationale for Hybrid hip Arthroplasty. It might be advantageous to use a bearing which has a low wear rate. The purpose of this study is present the medium term results of this Uncemented cup with a metal-on-metal bearing.

Methods: We reviewed the results of 119 hips (101 patients) who had the Uncemented Fitmore® cup (Sulzer/Zimmer Orthopaedics, Inc). In 66 out of the 101 patients the femoral component used was CF-30® (Sulzer/Zimmer Orthopaedics, Inc) used with cement. In 35 patients Thrust plate prosthesis TPP® (Sulzer/Zimmer Orthopaedics, Inc) was used. This is a bolt type device which is fixed on to the neck; the femoral canal is not violated. Of the 101 patients, 90(108 hips) were available for study. All had minimum of 5 years follow-up.

Results: Mean follow-up of the 90 patients is 87.4 months (range 60 – 129 months). The mean pre-op Harris hip score is 38.2. The mean post-op Harris hip score is 89.6 at the last follow up. Taking aseptic loosening as the end point the survival rate of the Fitmore cup is 100% at 11 years. Four cups were revised for other causes.

Discussion: Histological studies of retrieved metal-on-metal implants have always shown low volume of inflammatory tissue. Wear rate of metal-on-metal hips is 60–100 times lower than metal-on-polyethylene hips. In the medium to long term Uncemented cups fare better than cemented cups. It might be advantageous to use an Uncemented cup with a metal-on-metal bearing. This follow-up study which has a 100% survival rate at 11 years proves that.


W Dandachli J D Witt Z Shah R Richards V Sauret M Hall-Craggs

Introduction: Assessing coverage of the femoral head is a crucial element in acetabular surgery for hip dysplasia. Radiographic indices give rather limited information. We present a novel ct-based method that gives an image of the head with the covered area precisely represented. We used this method to measure femoral head coverage in a series of normal hips and in a prospective study of patients with hip dysplasia undergoing peri-acetabular osteotomy.

Methods: Thirteen normal and ten dysplastic hips were studied. On each CT scan anatomical landmarks were assigned on the 3d reconstructed image and used to define the frame of reference. Points were assigned on the femoral head surface and the superior half of the acetabular rim after aligning the pelvis in the anterior pelvic plane. An image was produced representing the femoral head and its covered part. The fraction of the head that was covered was calculated.

Results: The average femoral head coverage in the normal hips was 73.9% (sd 3.2). The average coverage in the dysplastic group was 50.7% (sd 7.9) and after undergoing peri-acetabular osteotomy the average was 67% (sd 6.2).

Conclusion: This is the first study to our knowledge that has used a reliable measurement technique to give an indication of the percent coverage of the femoral head by the acetabulum in the “normal hip”. When this is applied to assessing coverage in surgery to address hip dysplasia it gives a clearer understanding of where the corrected hip stands in relation to a normal hip, and this should allow for better determination of the likely outcome of this type of surgery.


SC Budithi R Pollock RK Logishetty AVF Nargol

Introduction: Pain after total hip arthroplasty (THA) can be caused by infection, aseptic loosening, heterotopic ossification, and referred pain. Psoas tendonitis is a rare cause of groin pain after THA and resurfacing arthroplasty. It is believed to be caused by psoas tendon impingement against a malpositioned acetabular component due to defective anteversion or centring and the use of oversized cups. We report 4 cases of psoas tendonitis following resurfacing arthroplasty and hybrid surface arthroplasty.

Methods: Between April 2004 and June 2005, we diagnosed 4 cases (3 female and 1 male) of psoas tendonitis among 152 cases of resurfacing arthroplasty and hybrid surface arthroplasty (2.6%). 116 patients had a hip resurfacing with ASR prosthesis (2 cases, 1.7%) and 36 patients had hybrid surface arthroplasty with ASR unipolar head on S ROM stem (2 cases, 5.6%). All these patients presented 2–5 months postoperatively with severe groin pain which was exaggerated when moving from the sitting position to the upright position and when going up stairs. Common causes of pain after hip arthroplasty, infection and loosening were ruled out. Radiological and ultrasound examination were performed.

Results: Ultrasound examination revealed thickening of psoas tendon in all cases and fluid collection around the tendon in one case. All cases were treated with corticosteroid injection under ultrasound guidance. Significant but temporary symptomatic relief was achieved in all cases.

Discussion: Psoas tendonitis should be considered in the differential diagnosis of groin pain after hip resurfacing procedures. Ultrasound examination is the initial investigation of choice and corticosteroid injection around the tendon is initial method of treatment. Computerized tomography and surgical options of management should be considered in resistant cases.


K Chettiar R Worth L David H Apthorp

Introduction: Recently there has been much interest in minimally invasive hip surgery, with less attention being directed to maximising the potential benefits of this type of surgery. We have developed a new multidisciplinary program for patients undergoing total hip replacement in order to facilitate an overnight hip replacement service.

Methods: The program involves a pre-operative regimen of education and physiotherapy, a modified anaesthetic technique, a minimally invasive surgical approach and a portable local anaesthetic pump infusion for post-operative pain control. Strict inclusion and exclusion criteria were developed based on age, medical status and social circumstances. Patients were mobilised on the day of their operation and discharged home with an ‘outreach team’ support network. No patient complained that their discharge was too early. Independent evaluation was performed using the Oxford Hip Questionnaire, the Merle d’Aubigne clinical rating system and Visual Analogue Pain Scores.

Results: Thirty seven patients underwent total hip replacement using the new protocol.

The average length of stay was 1.2 days. The mean pain score on discharge was 1.3/10. The Oxford Hip Questionnaire and Merle d’Aubigne scores were comparable to patients who underwent surgery prior to the introduction of the new protocol. Minimising in-patient stay for total hip replacement benefits the patient by reducing exposure to nosocomial infection and expediting the return to a normal environment for faster rehabilitation. This new program allows patients undergoing total hip replacement to be discharged after 1 night post operatively without compromising safety or quality of care.

Conclusion: Minimally invasive surgery with a suitable infrastructure can be used to dramatically reduce the length of stay in suitable patients. This can be achieved reliably, safely and with high patient satisfaction. In order to gain the benefit of Minimally Invasive Surgery we recommend introducing this type of comprehensive program.


A Nisar A Salama I R Scott

Introduction: The Centrament® (Aesculap, Tuttlingen, Germany) is modular hip system combined with a range of modular heads and acetabular components, enabling the system to cover a wide range of applications. We looked at medium term results in a district general hospital.

Methods: This is a retrospective cohort study. Information was obtained from patient notes and radiographs.

Results: One hundred and ninety two (n =192) total hip arthroplasties in 178 patients (14 bilateral) were followed up for at least 5 years (mean: 5.8 years; range: 5–9 years). The mean age of the patients at the time of surgery was 71.8 years (range, 38–91 years). The most frequent indication for surgery was osteoarthritis (94%). One acetabular cup was revised for aseptic loosening, and 2 cups were revised for recurrent dislocation. Two stems have been revised (one for aseptic loosening and one for prosthetic fracture). The dislocation rate was 4.2% during the initial fifty arthroplasties that reduced to 0.9% in the subsequent years. For radiological evaluation Gruen zones for the stem and DeLee and Charnley zones for the cup were used. The acetabular cup was satisfactory in 186 hips radiographs and showed asymptomatic non-progressive osteolysis in three cups. Two stems showed signs of osteolysis at nine years but the patients had no symptoms. Using the recommendation of revision as the endpoint, Kaplan Meier Survival Analysis showed a cumulative survival for the prosthesis as 97.3%, with stem survival of 99% and cup survival of 98.5%.

Discussion: In the medium-term, these results are comparable to other cemented hip prosthesis used in the UK.


V Khanduja S Ashraff G Malawa T Dolan

Objective: To determine whether patient information leaflets improve patient recall during the process of informed consent.

Design: Prospective randomised controlled trial which compared a group of patients who were posted a patient information leaflet with those given verbal consent only.

Setting: Orthopaedic Unit of a District General Hospital

Patients: 110 patients were selected, of which 57 were randomly allocated to receive patient information leaflets through the post and 53 were given verbal consent only.

Outcome Measure: The recall of information given to the patient. This was tested using a questionnaire on admission. Each patient was allocated a score out of ten.

Results: There was a significant difference between the group who received patient information leaflets compared to those who did not (P< 0.0001, CI 2.0 to 3.1).

Conclusion: Patient information leaflets are a useful tool for the surgeon to improve the recall of the information given to the patient, in order to facilitate informed consent.


J Bridgens P Norman I Stockley

Introduction: It is common practice to use additional antibiotics in bone cement for revision hip surgery. Ideally antibiotic elution would initially be rapid and then reduce to zero in order to reduce the risk of antibiotic resistance developing. There is evidence that the addition of antibiotics to bone cement leads to deterioration in mechanical properties. We have carried out a study to see if the addition of vancomycin to Palacos R40G and Smartset GHV affects their in-vitro antibiotic elution and mechanical properties.

Methods: Palacos R40G (contains 0.5g gentamycin per 40g mix) and Smartset GHV (contains 1g gentamycin per 40g mix) were used. 40g samples of the two cements with no additional vancomycin, 1g and 2g vancomycin were prepared by a standard method using vacuum mixing in a syringe. Antibiotic elution over a five week period was measured using an immunoassay method. Standard mechanical testing was carried out according to methods defined in ISO 5833.

Results: Smartset GHV eluted double the quantity of gentamycin as Palacos R40G, as would be expected. Both cements eluted more gentamycin when vancomycin was added. Smartset appears to elute more vancomycin than Palacos initially and then shows a more rapid tailing off. The mechanical properties of the two cements were the same with no statistical differences found between them. Both showed deterioration in flexural strength with addition of increasing vancomycin.

Discussion: Smartset may have improved qualities of antibiotic elution as compared with Palacos with similar mechanical properties. The presence of higher initial quantities of gentamycin does not lead to reduced mechanical properties.


J Daniel H Ziaee PB Pynsent DJW McMinn

Introduction: Metal ions generated from metal-metal joints are transported in plasma and within cells. Whole blood (WB) analysis is a good measure of systemic metal exposure because it includes both intracellular and extracellular compartments. Analysis of whole blood is technically more challenging than serum. But can serum levels be considered equivalent to whole blood levels in the assessment of systemic metal exposure?

Methods: 262 concurrent WB and serum specimens from patients after metal-metal hip arthroplasty were analyzed for metal levels by high-resolution mass-spectrometry (reporting limits 0.06μg/l for serum and 0.1μg/l for WB). The relationship between serum and WB levels were studied using four methods of agreement testing: paired t-test, Pearson correlation, Bland-Altman agreement and variability on normalized-scatter.

Results: Mean WB and serum chromium concentrations were 2.2 and 4.2μg/l (p< 0.001). Corresponding values for cobalt were 2.4 and 3.2 μg/l (p< 0.001). The normalized scatter (fig 1B) shows poor congruence between whole blood and serum levels especially at lower concentrations. Pearson correlation confirms poor agreement at lower concentrations even after excluding outliers.

Bland-Altman analysis (Figure 1A) shows the limits of agreement between serum and WB are unacceptably wide (1.7 to -5.1 for chromium) suggesting poor agreement.

Discussion: The proportion of metal ion levels in serum and blood cells shows great variability. With advances made inmass-spectrometry, poor instrument sensitivity is a non-issue. Is there then a case for continued use of serum as a measure of systemic metal ion exposure? It can be justified only if serum levels show good agreement with WB levels throughout the range of measurements. Concurrent analysis of serum and whole blood metal ion concentrations in the present study, do not show such an agreement with four methods of testing, suggesting that serum metal concentrations cannot be reliably used as an instrument to measure systemic metal ion exposure.


PS Sauvé J Mountney T Khan J De Beer ML Grover

As a result of the increased popularity of metal-on-metal bearings for total hip arthroplasty, concerns have been expressed about patient exposure to increased serum metal ion levels.

We therefore performed a retrospective review of patients with metal-on-metal, uncemented Ring total hip replacements with a minimum follow up of thirty years.

After allowing for prosthesis revision and patient mortality, 6 hips in 5 patients were reviewed and serum ion levels measured. Similar cohorts of patients with other combinations of bearings were compared with an age-matched osteoarthritic control group.

Serum cobalt and chromium levels in the metal-on-metal hip arthroplasty group were significantly higher than in all other groups and approximately five and three times greater respectively than in the group with no implants. Unlike the stainless steel-on-plastic group, the cobalt/chrome-on-plastic group showed significantly raised serum cobalt levels compared with the control group. It is of interest that patients who have had their metal-on-metal hip replacements revised to metal-on-plastic, have metal ion levels that are not statistically different to those of the osteoarthritic control group.

Though we acknowledge the small numbers of patients studied, no identifiable harmful effects were found.

We conclude that serum metal ions remain elevated throughout the life of the metal-on-metal articulation. Metal bearing hip arthroplasty is being used in ever younger patients and together with increased life expectancy we are exposing our patients to potentially harmful levels of metal ions throughout the life of the implant.


SB Bhagat SS Bhagat A Phadnis RJ Khan CJV Mann

Introduction: There is an increased risk of revision for aseptic loosening with a transgluteal approach as described in the Swedish Hip Register. Femoral component malpositioning is itself associated with a poor outcome. A cuff of posteriorly situated glutei during the direct lateral approach may result in levering the proximal stem anteriorly and the tip of the stem posteriorly and does not allow the entry point of the stem to be placed posteriorly at the level of neck resection resulting in possible malpositioning.

The purpose of this study was to determine whether there is a significant difference in femoral component alignment when the posterior and direct lateral approaches are compared.

Materials and methods: Forty patients underwent a direct lateral approach and forty a posterior approach (n = 80). Inclusion criteria included primary hip arthroplasty using a cemented Exeter femoral component. At 6 weeks a standard AP and a modified lateral radiograph were taken. Measurements were taken from digitized radiographs as follows:

AP radiograph

Tip of stem to outer medial cortex.

Tip of stem to outer lateral cortex.

Lateral radiograph

C Tip of stem to anterior outer cortex

D Tip of stem to posterior outer cortex.

Component alignment was defined as A – B and C – D.

Results: A–B was 0.71 for the modified direct lateral approach and 2.56 for the posterior approach. C–D was 1.47 for the direct lateral approach and 1.21 for the posterior approach. This difference was not statistically different using paired t tests as p > 0.05(P=0.69) for lateral views measurements.

Discussion: This study demonstrates that there is no significant difference between direct lateral and posterior approaches as far as femoral component alignment is concerned. The increased revision rate noted by the Swedish Hip Register when a transgluteal approach is likely to be multifactorial, but not likely to be due to femoral component malalignment.


JA Corner A Rawoot HV Parmar

Introduction: The Thrust Plate Prosthesis (TPP) is a neck preserving femoral component in total hip arthroplasty (THA), allowing direct load transfer to the medial cortex of the femoral neck. We present an evaluation of its use in young patients with hip arthritis.

Methods: A consecutive series of patients were reviewed at a minimum of 5 years after THA using the TPP. Harris Hip Score (HHS) and Oxford Hip Score (OHS) were recorded pre-operatively and at the last clinical review. Radiographic analysis was performed and patient satisfaction levels and complications were recorded.

Results: Between 1996 and 2000 we implanted 41 prostheses in 38 consecutive patients (3 bilateral). The mean age at time of surgery was 56 years (41–67) and the mean length of follow up was 71 months. The HHS improved from a mean of 42 points pre-operatively to 88 points at the last clinical review and the mean OHS also improved from 40 points to 18 points. 83% of patients expressed that they were ‘very satisfied’ with the procedure. Three cases have since required revision surgery secondary to peri-prosthetic fracture, early deep infection and aseptic loosening (1 case each). Only one other case has radiological evidence of loosening or poor cortical contact with the collar of the TPP. Two patients have experienced sub-luxation or dislocation of the prosthesis. Eight patients suffer discomfort when lying on the operated side.

Discussion: These are the first results of the TPP from the United Kingdom. Whilst many of these young patients treated with the TPP show excellent improvement in clinical outcome scores and a high level of patient satisfaction, the complication rate gives some concern. We support the selective use of the TPP to treat young patients with hip osteoarthritis.


M Moran C Heisel R Rupp AHRW Simpson SJ Breusch

Introduction: Cement pressurisation is key to achieving good cement-bone interdigitation in THR. To obtain adequate pressurisation the medullary canal must be sealed distally using a cement restrictor. The cement restrictor must remain stable in the femoral canal.

Methods: Five different cement restrictors were evaluated, namely the Exeter Cement Plug, Biostop G, Hardinge, Rex CementStop and a preinjected cement plug. The restrictor was deployed in a sawbone that had been reamed to produce a distal flare, based on radiographic measurements. Low viscosity bone cement pressurised using a cement ram connected to a 10bar air supply. An electronic pressure valve increased the pressure in the cement. Cement pressure and cement restrictor displacement were continuously measured. The pressure valve and recording of measurements was controlled by a customised computer package.

Results: The Rex CementStop withstood the greatest pressures (mean 565.8kPa). This was a significantly greater pressure than any of the other cement restrictors (p< 0.001). Pre-injected cement plugs were able to resist the next highest pressures (mean 350.4kPa). They did not displace but leaked cement and were technically difficult to deliver in the distal femur. Cement restrictors that function well above the isthmus were ineffective (Biostop mean 118.7kPa) or could not be deployed below the isthmus (Exeter). The Hardinge recorded a mean 162.3kPa.

Discussion: During pre-operative templating it is important to consider where the cement restrictor will sit in the femur. When the cement restrictor is going to be deployed beyond the femoral isthmus, an alternate method of cement restriction may need to be used. Universal sized plugs (e.g. Hardinge) function poorly in this situation. Press-fit plugs such as Biostop and Exeter are severely compromised when inserted past the femoral isthmus. Pre-injected cement plugs are variable in efficacy. The expandable Rex CementStop reliably occluded the femur, allowing the highest pressures to be generated.


M Khan JH Kuiper T Takahashi JB Richardson

Introduction: The wear particles produced from the metal-on-metal hip prosthesis causes measurable rise of metal ion levels in the patient’s body fluids. Wear of the bearing is directly related to its use. The goal of this study is to test two hypotheses. Firstly, that exercise causes increased wear particles in vivo which can cause immediate measurable rise in the serum metal ion levels. Secondly, that this rise in metal ion level is different for different types of bearings.

Material and Methods: Eighteen participants were allocated to four different groups i.e. Birmingham Hip Resurfacing prosthesis group, Cormet 2000 resurfacing prosthesis group, Thrust plate prosthesis group (28mm metasul articulation) and group four with out any metal work. Blood samples were taken immediately before, immediately after and one hour after exercise. Plasma cobalt and chromium was determined using Inductively-Coupled-Plasma-Mass-Spectrometry and Dynamic-reaction-cell respectively with detection limit of 2nmol/l each.

Results: The four patient groups were comparable. A significant increase (p< 0.005) in serum cobalt and chromium of 13% and 11% respectively, was noticed after the exercise. Rise of cobalt levels in patients with a resurfacing MOM was 8.5 times (BHR group) and 6.5 times (Cormet group) larger than in those with a Metasul (p=0.021 and p=0.047). Neither rise of metal levels nor baseline levels correlated with any other factor (p> 0.27).

Discussion: Physiologic exercise causes immediate detectable rise in the serum metal ion levels. The increase is predominantly related to the size of the bearing surface. Exercise-related-cobalt-rise could be used to assess the tribology of the different metal on metal designs in vivo for future research


JT Daniel A Kamali SS Saravi M Youseffi R Ashton T Band DJW McMinn

Introduction: modern cementless joints depend on bony ingrowth for durable long term fixation. Increased friction and micromotion in the early weeks can prevent ingrowth and affect long-term success.

Most friction studies are conducted in a bovine serum- carboxymethylcellulose (bs-cmc) medium. Following implantation however, the joint is bathed in blood which contains macromolecules and cells. The effect of these on friction is not fully understood.

A progressive radiolucent line (fig 1) observed in some low clearance resurfacings raises the concern that increased friction may be affecting component fixation. The purpose of this investigation was to study the effect of clearance on friction for a given bearing diameter in the presence of blood as lubricant.

Methods: Six Birmingham Hip Resurfacing devices with a nominal diameter of 50mm each and a range of diametral clearances (80, 135, 175, 200, 243 and 306μm) were used. Frictional measurements were carried out on a Prosim Hip Friction Simulator (Simsol Simulation Solutions, Stockport, UK). The test was conducted sequentially with whole blood (viscosity 0.009Pas) and a BS-CMC mixture as the lubricants (viscosity 0.01Pas).

Results: Low clearance devices (80–175μm) generated higher friction with blood than with BS-CMC (fig 2). With blood as the lubricant, low clearance devices generated much higher friction than higher clearance devices (200–306μm).

Discussion: Ongoing research into the in vitro performance of bearings is performed in hip simulators with lubricants that are believed to simulate joint fluid in terms of viscosity. However these lubricants are unable to simulate the friction effects of macromolecules.

The results of this study suggest that reduced clearance bearings have the potential to generate higher friction when blood is the lubricant. this higher friction in the low clearance bearings may produce micromotion in the early postoperative period and hamper bony ingrowth resulting in impaired fixation with long-term implications for survival.


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A Ndzenque M Beverly

Introduction: We present our results after 10 years use of the Kent hip.

Methods: Between 1994 and 2004, 58 patients (m19, f39) aged 52 to 90 (mean 76) had a Kent hip. Indications were for a loose implant (22), recurrent dislocation (6), femoral or stem fracture (9), and other causes (13). An antero-lateral approach with an antero-lateral longitudinal femoral window was used to remove the previous stem and cement. The window was re-attached by cross screws. An average of 7 (4–10) cross screws were used. An uncemented Biomex cup and polythene liner was used in 48 cases and 10 cups were cemented. A modular 28 mm head and variable length neck was used. Recorded anaesthetic grade was ASA Grade II for 33 patients and ASA Grade III in 13 patients.

Results: Operative time was 130 +/− 37.5 min. Mean recorded blood loss was 1300ml (300–4000ml). Patients were up partial weight bearing at a mean of 5 days (2–80). Hospital stay was 19 days (7–212). There were 3 hospital deaths, one from MRSA sepsis, one chest infection and one MI.

Complications included dislocation (13 out of 53 patients or 24.5%), heterotopic ossification (47%), screw fracture (8%), superficial infection (11%) and deep infection (5.7%). Survival tables show an implant survival rate of 85% at 5 years.

Discussion: Most dislocations settled without further surgery. Heterotopic ossification was minor. The Kent hip system is a flexible and robust solution for a wide range of difficult revision cases. It allows early full weight bearing. We prefer the Kent implant to massive re-cementing, bone grafting or Girdlestone excision. We recommend this device for wider use.


KM Venu Y Inaba Z Wan LD Dorr

Introduction: The long-term results of total hip replacement can be improved by accurate placement of the implants, leading to restoration of hip biomechanics and prevention impingement from of implant malposition. Pelvic obliquity from patient positioning during surgery prevents accurate intra-operative assessment of component placement. Computer navigation assisted total hip replacement can potentially eliminate these problems by providing feedback on prosthetic placement during surgery. The purpose of our study was to assess the accuracy of the component placement in computer navigation assisted THRs performed in our institution.

Methods: A total of 154 computer navigation assisted total hip arthroplasties performed between January 2004 and January 2005 were prospectively included in this study. Image free optical based navigation system (Navitrack™) was used. All procedures were performed by the senior author using MIS and open posterior approaches. Two independent observers performed analysis of the position of components and leg length discrepancy from standardized hip radiographs. Navigation values during surgery were compared with postoperative radiographic evaluation.

Results: The mean abduction and anteversion angles of acetabular component in postoperative radiographs were 41.4 ± 6.1 and 22.6 ± 3.8 degrees respectively, in comparison to the navigation values of 40.9 ± 4.0 and 22.9 ± 3.6 degrees respectively. The femoral neck offset and leg length discrepancy calculated from navigation were with in a mean of 1.5mm and 2.8mm, respectively. There was one complication consisting of a peri-prosthetic femoral fracture that was recognised during surgery and treated with revision of the femoral component to a long-stem prosthesis. There was no early post-operative dislocation or deep infection in this series.

Discussion: This study showed that computer navigation assisted THR provided predictable and reproducible results with accuracy in component placement and restorations of femoral neck offset and leg length.


NC Carrington R Sierra GA Gie AJ Timperley MW Hubble RSM Ling JR Howell

Introduction: We describe an update of our experience with the implantation of the first 325 Exeter Universal hips. The fate of every implant was known.

Methods: This is a review of the prospective data collected from the first 325 Exeter Universal stems (309 patients) inserted between March 1988 and February 1990. The procedures were undertaken by surgeons of widely differing experience. Clinical and radiological review was performed at a mean of 15.4 years.

Results: At last review 185 patients had died (192 hips). 104 hips remain in-situ. Survivorship at 17 years with revision for femoral component aseptic loosening was 100% (95% CI 97 to 100), with revision for acetabular component aseptic loosening was 92.85% (95% CI 87.0 to 96.2) and with any re-operation as the endpoint was 83.99% (95% CI 77.1 to 90.27). 12 patients (12 hips) were not able to attend for review due to infirmity or emigration, and scores were obtained by phone (x-rays were obtained in 4 patients). Mean D’Aubigné and Postel scores (Charnley modification) at review were 5.4 for pain and 4.5 for function. The mean Oxford score was 21.46 +/− 9.52 and the mean Harris score 73.35 +/− 17.32. On radiological review there were no femoral component failures. Three sockets (2.9%) were loose as demonstrated by migration or change in orientation (two patients were asymptomatic) and 5 sockets (4.8%) had radiolucent lines in all 3 zones but no migration. There are two patients awaiting socket revision.

Discussion: The high rate of clinical and radiological success of the Exeter Universal stem seen at 12 years is sustained at 17 years. Further cup failures have occurred but overall survivorship remains good. With the favourable long-term behaviour of the original Exeter stem, we feel optimistic that good function of the Universal stem will continue through the third decade.


S M Gajjar M L Porter

Aim of the study: To evaluate the results of metal-on-metal resurfacing hip arthropalsty in young patients

Materials and Methods: Between February 2000 and December 2004, this operation was performed in 181 patients (205 hips) using the posterior approach. The main indications were osteoarthritis, osteonecrosis, hip dysplasia, post-traumatic arthritis, perthe’s disease and slipped capital femoral epiphysis. There were 142 males and 39 females aged 26 to 68 years (average 47.4 years). 136 patients had a minimum 3 year follow-up (range 1–5 years). Clinical and radiological evaluation was performed at 3 months, 1 year, 2 years and 5 years from time of surgery. All patients were scored using the Charnley’s modification of Merle d’Aubigne score preoperatively and at last follow-up. Radiological evaluation included grading acetabular and femoral zones for loosening, determining stem-shaft angle, hip ratio. The endpoint for outcome evaluation was revision which was two in this series. Survivourship analysis was performed by Kaplan-Meier analysis. The results in our patients were encouraging with most returning to sporting activities at an average of 12 months. 1 patient with bilateral hip resurfacing had evidence of osteolysis after surgery and had occasional hip pain until last follow-up. Complications like neck fracture, heterotrophic ossification were not seen in our series.

Conclusion: Early results of metal-on-metal resufacing arthroplasty in our series are encouraging. Continued follow-up and evaluation remains important to determine the long term results of this operation.


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DM Wright DH Sochart

Introduction: The Opera Acetabular cup (Smith and nephew) was designed in North Manchester General and has been in use since 1997. The initial results were with multiple surgeons, different approaches and 2 different stems. We report the early results of the opera cup in primary hip replacements using the C-Stem.

Methods: This is a prospective radiological follow up of patients operated on between June 2000 and November 2004. 202 consecutive primary hip replacements were carried out using the Opera cup and a standard C-stem. All operations were performed by a single surgeon using the posterior approach. Initial and annual x-rays were studied and the following measurements taken: cup angle; radiolucent lines in the bone-cement interface of the acetabulum; heterotopic ossification; radiolucent lines or osteolysis in the femoral component and stem orientation.

Results: Full data is available in 166 hips performed on 149 patients. Average follow up is 37 months (12–65). 84 patients were female and 65 male. There were 56 left hip replacements, 76 right hip replacements and 17 were bilateral. 162 hips had an elite head whereas 4 had a ceramic head. Average cup angle was 44.6 degrees. 20 Cups had 0.5mm lucency in zone 1 of the acetabulum and 1 cup had 1mm lucency in zone 1. None were progressive. 14 patients had grade 1 heterotopic ossification 3 patients had grade 2. 1 stem was in valgus and 13 stems were in varus.

Complications were 1 calcar fracture and 1 greater trochanter fracture (both of which required circlage wires). There was also 1 temporary femoral nerve palsy which resolved in 3 months. There were no fatal PE’s, deep infections or dislocations. No hips have required revision.

Discussion: We conclude that in the short term the Opera cup is performing to the standard required by NICE.


V Kannan J D Witt T White

Introduction: We report the results of activity and functional outcome of matched pair analysis comparing hip resurfacing with total hip replacement with a minimum follow up of 22 months

Materials and Methods: 14 matched pairs were selected in terms of age (within 4 years), sex and diagnosis, of which 10 pairs were females and 4 pairs were males The mean age was 49.7(19 – 63). The Birmingham hip resurfacing was used in all patients in the resurfacing group and the Furlong HAC stem in all cases in the THR group with the CSF cup in most cases. The mean follow up in BHR group was 5.2 years (1.7 – 9.2) and 2.4 years (1.8 – 3.6) in THR group. Functional outcome was measured using Harris Hip score, WOMAC, SF 36 and the UCLA and Tegner activity scores

Results: The mean Harris Hip score, SF 36, WOMAC, UCLA and Tegner activity scores in the BHR group were 86.8, 77.3,49.7, 6.1 and 3.6 respectively. In the Furlong group the Harris Hip score, SF36, WOMAC, UCLA and Tegner activity scores were 82.9, 79.0,29.5, 5.6 and 3.2 respectively. There was no statistical difference in the mean scores between the two groups.

With regard to functional activity, 21% of patients in both the groups scored 8 or more on the UCLA activity scale. 21% of patients in the BHR and 14% in the Furlong group scored 3 or more on the Tegner activity scale

Conclusion: In our study, hip resurfacing was not associated with a significant increase in activity level or functional outcome compared with total hip replacement.


G Shah G Singer

Introduction: Metal on metal hip resurfacing is a bone conserving procedure with excellent medium term results. A retrospective audit of 150 consecutive Birmingham Hip resurfacings, performed by a single surgeon at a DGH was carried out.

Materials and Methods: We report 150 hip resurfacings implanted between June 2001 to June 2004. There were 99 male and 51 female hips. The mean age was 50.7 years (38–75years). Range of follow up was 6 months to 45 months (average 20.1 months)

Pre operative diagnosis was Osteoarthritis (n=135), osteonecrosis(n=8),traumatic(n=2),dysplasia(n=3),Slipped capital femoral epiphysis (n=1) and ankylosing spondylitis (n=1). Al hips were implanted via the posterior approach. Clinical assessment, by postal questionnaire, was by pre and post-operative Oxford Hip scores (OHS) and X-rays were reviewed.

Results: Range of follow up was 6 months to 42 months (average 20.1 months). No patient was lost to follow up. The mean pre operative Oxford hip score was 41 (r=27–56). The score was 15.1 (r=12–29) at the time of questionnaire.

Complications included: One femoral neck fracture at 3 months requiring revision to a stemmed “big ball” THR, one deep infection requiring early wash out with salvage of the hip prosthesis, (both the patients are now doing well. OHS 13 and 15 respectively) and one asymptomatic stress fracture of femoral neck, which healed without intervention (OHS 12).

There was one dislocation in a neuropathic hip requiring bracing. (OHS 29). There was one retained alignment pin needing removal. Otherwise patients were highly satisfied with the operation with excellent function and Hip scores.

Conclusion: Our study has demonstrated that, in the short term and in young age group, this prosthesis gives excellent functional results, with an acceptably low complication rate. Long term surveillance of these patients will provide further data to compare our results with specialist centres.


G Shah J De-Leeuw

Introduction: Rat-bite fever is an uncommon illness caused by Streptobacillus moniliformis or Spirillum minor. We present an unusual case of rat bite fever involving a left cemented total hip replacement after a rodent bite.

Case report: A 38-year-old lady, presented with poly arthralgia, who had Total Hip replacement for arthritis secondary to developmental dysplasia of Hip(one year ago), presented with signs & symptoms suggestive of infective joint pathology. Examination revealed painful restricted joint movements.

Initial blood tests revealed very high ESR, c-reactive proteins with leucocytosis. Blood cultures were negative. X-rays revealed dislocation of Total hip replacement Ultrasound scan and CT scan revealed a large collection of fluid in the Left Total Hip Replacement.

Aspirate from the affected joints revealed gram negative bacilli, Streptobacillus moniliformis. The joints were all washed out arthroscopically. She was put on intravenous antibiotics and continued for six weeks. The inflammatory markers normalised after six weeks. Follow up x-rays of the left hip prosthesis do reveal some signs of osteolysis and surveillance is ongoing.

Discussion: Prosthetic replacements are now commonplace, with large number of patients keeping pets. Septic arthritis following the rat bite has been reported. As far as we can tell from the available literature that it has not been reported in a joint prosthesis. The long- term outcome is unknown. The possibility of low grade infection involving the joint prosthesis and the association of this organism with endocarditis is a cause for concern.


L A Crawford R Mehan D Q Donaldson G J Shepard

Aims: To determine the anthropometric measurements of bony landmarks in the knee using MR scans and so assist revision knee surgeons in prostheses placement.

Methods: We analysed 100 MR scans of patients aged 16–50 (50 male, 50 female) which were performed for meniscal pathology, patellar dislocation and ACL injury. Those over the age of 50 or with symptoms suggestive of general osteoarthritis, or where the epiphyses had not yet fused were excluded. All measurements recorded were to the level of joint line and are shown below.

Conclusions: To ensure near normal knee mechanics are achieved during revision knee surgery the joint line should be within 5mm of the original. Our study provides mean values for the distance from various bony landmarks to the joint line in non-arthritic knees on MR scan. The use of the medial epicondyle value as a sole reference will place the joint line within 5mm in 88% of males and 96% of females. Use of multiple landmarks further increases accuracy. The final position of the joint will depend on trialling prostheses.


E Mughal P Desai F Ashraf Y Khan D Dunlop R Treacy A Thomas

Weight gain is often reported by patients who succumb to impaired activity as a result of progressive osteoarthritis of the hip or knee. Optimistic views of weight loss after joint replacement are often held by patients. We studied the affect of lower limb arthroplasty on body weight.

We reviewed 144 patients having undergone hip and knee arthroplasty and were functionally well. Infected cases were excluded. Average age was 65 years and average follow up was 27 months. The Body Mass Index (BMI) was prospectively measured at follow up and compared to immediate pre-operative BMI.

Our findings demonstrated an average rise in BMI post-operatively which was statistically significant. A rise in post operative BMI was seen in patients who were obese to start with or those who had undergone a total hip replacement (statistically significant). Moderate rises were seen in patients who had underwent hip resurfacing procedures or those who were overweight preoperatively (p=0.06).

These findings are useful in informing patients of achievable expectations following joint replacement surgery and preoperative overweightness should be treated as a separate entity unrelated to co-existing joint degeneration.


V Khanduja S Ashraff G Malawa T Dolan

Objective: To determine whether patient information leaflets improve patient recall during the process of informed consent.

Design: Prospective randomised controlled trial which compared a group of patients who were posted a patient information leaflet with those given verbal consent only.

Setting: Orthopaedic Unit of a District General Hospital

Patients: 110 patients were selected, of which 57 were randomly allocated to receive patient information leaflets through the post and 53 were given verbal consent only.

Outcome Measure: The recall of information given to the patient. This was tested using a questionnaire on admission. Each patient was allocated a score out of ten.

Results: There was a significant difference between the group who received patient information leaflets compared to those who did not (P< 0.0001, CI 2.0 to 3.1).

Conclusion: Patient information leaflets are a useful tool for the surgeon to improve the recall of the information given to the patient, in order to facilitate informed consent.


M Maru V Kumar G Akra A Port

Introduction: The commonest surgical approach for total knee arthroplasty is medial parapatellar approach. This involves splitting the quadriceps tendon, potentially destabilising the extensor mechanism. The midvastus approach involves splitting the vastus medialis muscle instead of entering the quadriceps tendon, therefore, minimising interruption of the extensor mechanism without compromising the exposure of the knee.

Objective: To compare clinical parameters associated with medial parapatellar and midvastus approaches for total knee arthroplasty in the early postoperative period.

Methods and results: We present a prospective observational study of 88 patients undergoing primary total knee arthroplasty using medial parapatellar or midvastus approach (44 in each group). The prosthetic design and physical intervention was standardised in all the patents. The Oxford Knee Score, pain scale, knee flexion, unassisted straight leg raise, standing and walking were compared at 3rd, 5th and 7th day postoperatively, then at 6 weeks and at 3 months. The patients and physiotherapist were blinded to the type of approach used. The average age was 67 years (range 42 to 88). There were 49 women and 39 men. The average hospital stay was 7 days (range 2 to 15). There was statistically significant difference in duration of hospital stay, unassisted straight leg raise and standing at 3 days (p=0.001) and pain scale at 5 days, all in favour of midvastus approach. There was no statistically significant difference in Oxford Knee Scores and duration to achieving full flexion and walking. The average duration to achieving straight leg raise for the midvastus group was 5 days and for the medial parapatellar approach group was 8 days

Conclusion: The study shows that total knee arthroplasty performed through the midvastus approach resulted in less postoperative pain, earlier unassisted straight leg raise and ambulation, therefore, shorter hospital stay as compared to medial parapatellar approach. This may be of benefit to the patients due to less discomfort after surgery, and to the healthcare system due to shorter hospital stay for patients.


M Albrizio A D Patel

Background: The purpose of this study was to evaluate the relationship between body mass index and early complications following total knee joint replacement surgery.

Methods: 527 patients who underwent a primary knee replacement were included in this study. All these patients were subjected to a pre-operative assessment and then followed up at six weeks and one year following surgery. Any complication that occurred during this period was recorded. Complications were grouped into systemic and local, each group being subdivided into minor and major. Collected data were analysed by the SPSS version 12. Chi-square tests, t-test analysis, univariate logistic regression studies and multivariate analysis were performed.

Results: 64 patients (12,1%) were found to have an early complication following knee replacement surgery. 36 patients (6.8%) were found to have a major local complication. Overall BMI did not seem to influence the rate of complication. After stratification of patients per BMI, there appeared to be a weak correlation between BMI and early complications but this was not statistically significant. A stronger correlation was found between the surgeon and presence of complication.

Conclusions: BMI has a weak correlation to early complications following joint replacement surgery. The operating surgeon seems to have a stronger correlation to early complications as compared to BMI.


A J Wilkinson R M Nicholas

Purpose of the study: To audit the radiological position of the tunnels following reconstruction of the anterior cruciate ligament (ACL).

Methods: Postoperative radiographs were obtained on patients following ACL reconstruction in a single surgeon series. The positions of the tunnel in the femur and the tibia were measured and recorded. The tunnel positions were compared to the recommended positions as established by literature review. Lateral radiographs displaying greater than 2mm of imperfect projection in relation to the femoral condyles were noted.

Results: 108 radiographs were collected from 105 patients, 60 were right knees and 48 were left. There were 88 men and 17 women.

When measured along Blumensaats line from the anterior condylar surface, the femoral tunnel in the saggital plane should be found at 75% of the total anteroposterior distance, the recorded figure in this audit was 74%. Measured from the anterior edge in the saggital plane, the tibial tunnel should be found at 44% of the total tibial depth, our measurements averaged 40%. The tibial tunnel in the coronal plane should be found at 45% of the total width from the medial edge, our measurements averaged 46%.

57 (53%) of the radiographs demonstrated imperfect lateral projection of greater than 2mm.

Conclusion: The position of the tunnels analyzed in this audit compare favourably with the positions recommended in the available literature. Over 50% of the lateral radiographs displayed imperfect lateral projection greater than 2mm. Imperfect lateral film projection affects the apparent position of the tunnel. Any interpretation of position as it appears on a two-dimensional image must take into account possible errors in the image.


I R Gill P D Hamilton S J Pearce G Marsh

This is a prospective study of 74 consecutive LCS total knee replacements of which 34 were meniscal-bearing and 40 rotating-platform total knee arthroplasties comparing functional and radiological outcome measures of the New Jersey total knee replacement.

The study is based on a cohort of 96 patients who were followed up over a period of 8.6 to 15.6 years (mean 11.8 years). 49 patients (64 knees) were living and 5 patients were lost to follow-up. At time of follow-up 37 patients were dead. The patients were aged 23 to 81 (mean 64.5) at the time of surgery.

The methods used include a pre- and post-operative New Jersey Orthopaedic Hospital Scoring Scale (NJOHSS). In addition the cohort were assessed postoperatively using the Knee Society Score (KSS) and the Knee Society Radiological Evaluation Form (KSREF).

The results of the study showed that there was a significant overall improvement in the NJOHSS (mean improvement = 22.4 points) with 81% of the cohort scoring ‘good to excellent’ post-operatively. When the two types of arthroplasty were compared there was no significant difference in improvement in the NJOHSS. However, both the ‘Post-op’ and ‘Function’ components of the post-operative KSS were greater in the rotating-platform total knee replacement. The comparison of the post-operative KSREF did not show any significant differences between the two types of arthroplasty.

Revision procedures were carried out in 3 patients with meniscal-bearing arthroplasty and 2 patients with rotating-platform arthroplasty. Of the Meniscal-bearing group two were for sepsis and one required liner exchange. Both of rotating-platform group were revised for aseptic loosening.

We therefore conclude that there was excellent long-term survival of the LCS knee arthroplasty in this cohort and there was no significant difference in functional outcomes for either knee replacement. We also note that there have been no revisions for aseptic loosening in the meniscal-bearing group to date.


AM Perera N Gogi S Bathla A Dutta BK Singh

Background: Aseptic loosening of the tibial component is the one of the commonest cause of failure following a TKR. Good cement penetration into bone can reduce this and this has led to the development of new devices and techniques to improve the pressurisation during the cementing process.

We have conducted a case controlled study on a novel cementing technique and compared the results with published optimum levels.

Methods: 104 patients that underwent TKR at our institution were studied. Half of these were cemented using a double mix of cement inserted under pressure via an inexpensive alternative to the cement gun. The data was collected prospectively and included patient information, knee outcome scores and radiological assessment and there was a minimum 4 years follow-up.

Results: We found a significant difference in the number of early lucent lines as well as the size of the cement mantle particularly in the most important Zones. Despite pressurisation 1 of the 14 zones did not improve and we have examined the reasons for this.

In order to achieve optimum cement penetration we recommend that attention is paid to good pressurization and cement penetration and describe our technique for doing this.


H Nalwad M Agarwal B N Muddu M Smith Mr. J K Borill

Aim: To evaluate and assess the validity and accuracy of various described ways of performing the McMurray’s test in the diagnosis of meniscal tears.

Material & Methods: Prospective study with patients divided into seven groups based on seven described ways of performing McMurray’s test. Twenty-five patients in each group, aged between 15 to 60 years-undergoing arthroscopy of knee for clinically suspected meniscal tear. Exclusion criteria were ACL tear on arthroscopy, radiological or arthroscopic evidence of osteoarthritis and patients within six weeks of injury.

All patients were assessed preoperatively with knee examined in one of seen different methods. EUA followed by arthroscopy. Clinical and arthroscopic findings were correlated and sensitivity and specificity were determined.

The study is ongoing with following results.

Conclusion: Accuracy of McMurrays test ranged between 0 to 95% in various studies. Factors determining outcome include patient selection difference in applying test and interpretation of results. McMur-rays original description included no varus or valgus stress and a click a was positive test. Other descriptions include varus or valgus stress and apart from click pain is also considered a positive test. Comparisons among results in literature are difficult with confusing results. Our study is incomplete but trends suggest Reider’s method may be the most accurate.


J McConway R K Wilson D O Molloy L Ogonda D E Beverland

Introduction: Blood loss is a major concern following total knee arthroplasty (TKA) frequently resulting in blood transfusions postoperatively. Various strategies exist to reduce blood loss and allogenic transfusion requirements. This study investigates the effect of immediate postoperative flexion on blood loss and transfusion requirements following TKA.

Methods: 180 consented patients undergoing primary TKA by a single surgeon were enrolled into a prospective randomised controlled study. 90 patients were randomised to have the operated knee nursed in extension postoperatively, and 90 patients to have the knee nursed in flexion for six hours postoperatively. Both groups followed a strict transfusion protocol. Data collected included calculated pre- and postoperative haemoglobin and haematocrit which was used to calculate total blood loss. Units transfused and postoperative complication rates were also recorded.

Results: There was no significant difference in demographics or factors predisposing to bleeding between the groups. The mean total blood loss was 1841mls for those in the extension group compared with 1587mls in the flexion group (p=0.02). The mean number of units transfused in the extension group was 0.78 units/patient compared with 0.36 units/patient in the flexion group (p=0.004). There was no significant difference in pain scores between the groups (p= 0.62).

Conclusion: This study shows that the use of immediate postoperative flexion significantly reduces calculated total blood loss and transfusion rates following TKA.


D O Molloy J McConway H A P Archbold L Ogonda Mr D E Beverland

Patients and Methods: One hundred and fifty patients with pre-operative haemoglobin levels of 13.0g/dl or less were enrolled into a randomised controlled trial comparing the blood saving effect of intravenous tranexamic acid and topical fibrin spray on blood loss following primary total knee arthroplasty.

Those randomly assigned to the Tranexamic Acid group received 500mg intravenously five minutes prior to tourniquet deflation and a repeat dose three hours later. Those assigned to the Topical Fibrin Spray group received 10mls of the combined product intra-operatively. Those in the control group received no pharmacological intervention.

Results: There was a significant saving in total calculated blood loss for those in the topical fibrin spray group (p=0.016) and the tranexamic acid group (0.041) compared with the control group with losses of 1190mls, 1225mls and 1415mls respectively. The increased reduction in blood loss in the topical fibrin spray group was not significantly different to that in the tranexamic acid group (p=0.72).


SD Muller DJ Deehan JP Holland LM Kirk S Outerside PJ Gregg AW McCaskie

We report the results of a prospective randomised controlled clinical trial assessing the radiosterophotogrametric analysis (RSA), clinical and radiological performance of a metal backed and an all-polyethylene tibial cruciate retaining, condylar design, PFC-TKA up to twenty four months.

65 patients were recruited, of which 41 patients were randomised. There were 20 metal backed and 21 all-polyethylene. None were lost to follow-up. There were no significant inter-group demographic differences. We found a significant increase in SF-12 and Oxford knee scores after surgery in both groups. No significant difference was found between the groups in the RSA, SF-12, Oxford Knee score, radiological alignment and range of movement at 6, 12 or 24 months. At 2 years one metal backed implant showed translational migration > 1mm. No all polyethylene implant migrated > 1mm. Further analysis identified possible progressive subsidence of the metal backed implants compared to all-polyethylene implants, although the magnitude of this difference was very small.

We conclude that in the uncomplicated primary total knee arthroplasty, all polyethylene PFC-_ tibial prostheses had equivalent performance to the metal backed counterpart, using RSA as the primary assessment instrument at 24 months. We found no differences between the two designs as assessed by the secondary instruments: SF-12, Oxford knee score, alignment and range of movement at 24 months. Should half of all primary total knee replacements performed in the UK receive an all-polyethylene tibial implant, the estimated annual cost saving would be 21 million pounds per annum.


H Deo R Sharma M Wilkinson

Aim: To assess pain control, functional outcome and patient satisfaction following day surgery ACL reconstruction.

We report the results of 60 consecutive primary anterior cruciate ligament (ACL) reconstructions performed by a single operator at King’s College Hospital Day surgery unit. A “3 in 1” nerve block was used after general anaesthesia. Semitendinosis and gracilis were harvested from the ipsilateral side, doubled and implanted arthroscopically. Patients were discharged the same day with oral analgesia. The mean age was 34.7 years old (range 18–58). Mean period between injury and reconstruction was 26.9 months (range 6–63 months). Mean follow-up was 38 months (range 7–86 months). Average post operative pain score was 3.86 with an average analgesic requirement of 11.2 days (range 0–50 days) Mean Modified Lysholm score was 85.63 (range 31–100) and mean IKDC score was 79.83 (range 37–100).

In conclusion we found that following day surgery ACL reconstruction, pain relief was adequate in most cases, functional outcome was rated good or excellent by 78% of patients and 91% were satisfied with the overall service.


M M Utukuri H S Somayaji G S E Dowd D M Hunt

Aim: This is a report on outcome of Complete Trans-physeal ACL reconstruction in a group of 24 children with open physes of whom 6 were under 12 years (Pre-pubertal).

Materials & Methods: A group of twenty-four children with an average age of 13 years were reviewed. Six children were aged 12 or under at the time of operation. There were 21 boys and 3 girls. The follow-up ranged from 12 to 72 months (mean 37.8 months).

ACL Reconstruction was done by a standard 4-strand hamstring technique using an endobutton proximally and a spiked washer and screw distally in the tibia.

The IKDC, Lysholm and Tegner scores were used to assess the knees pre and post-operatively. Stability was measured using the KT-1000 arthrometer.

Results: Common modes of injury were football, rugby, skiing and squash. The left side was involved in 13 patients, and the right side in 11 patients. Interval between injury and surgery ranged from 3 to 22 months with an average of 8 months. Meniscal repair was carried out in 9 out of 14 patients with meniscal tears. The average Tegner score before injury was 7.7, before operation was 4 and at the last follow-up was 7.6. The average pre-operative Lysholm score was 54.6 compared to the post-operative score of 93. There was no incidence of angular deformity or a limb length discrepancy. There has been 1 re-rupture in a child aged 11 years 11 months at operation but no meniscal injuries. The outcome in the 5 other children aged 12 or less at the time of operation has been as good as the older children.

Conclusion: Reconstruction of the anterior cruciate ligament using a trans-physeal technique gives good results in pre-pubertal children and in adolescents.


M Goddard A J Rees

Purpose: To quantify the amount of agreement among UK orthopaedic surgeons regarding the natural history and treatment including surgery and rehabilitation of the ACL deficient knee.

Methods: Following from Marx et al (Arthroscopy. 2003 Sep;19(7):762–70) a surgeon mail survey was performed to 360 members of the British Association for Surgery of the Knee. Surgeons who had treated ACL deficient patients in the last year were asked to complete the survey. Thirty questions were included to determine the surgeons’ opinions regarding the natural history of the ACL deficient knee, indications for surgery and patient selection, surgical treatment and rehabilitation. Clinical agreement was present when 80% or more agreed on the same response option.

Results: 150 surgeons in total responded to the survey; 121 had treated ACL deficient patients in the past year. The mean age was 48.9 years and 83% considered their practice to be a subspecialty in knee surgery. The mean number of ACL reconstructions performed in the past year was 41 (range 1–210). Clinical agreement was present for 12 (40%) of the 30 questions; surgeons disagreed on 18 (60%) of the questions.

Conclusions: Similar significant variation regarding the management of ACL injuries is seen among members of BASK as among members of the American Academy of Orthopaedic Surgeons (AAOS). Clinical disagreement included whether ACL deficient patients can participate in all recreational sporting activities, that ACL reconstruction reduces the rate of arthrosis in the ACL deficient knee, and the use of bracing in non-surgically treated ACL deficient knees. Surgeons also disagreed about age, open growth plates, radiographic evidence of osteoarthrosis, pain, and, repairable and unrepairable meniscal tears in ACL deficient patients.


V T Veysi S R Bollen

Purpose: The aim of the study was to evaluate whether the recognition rates of ACL injuries had improved in the decade following the original paper published by the senior author.

Methods: Prospective data collection using a standard questionnaire on all patients presenting to a dedicated soft tissue knee injury clinic. There were 103 patients with a median age of 31.

Results: 94 out of the 103 patients gave a typical history of an ACL injury. The mean time to referral to this specialist clinic was 92 weeks. The commonest mechanism of ACL injuries was sports (88/103), with soccer making up the vast majority. The correct diagnosis was made by 13% of A& E staff, 30% of GPs and 57% of Orthopaedic surgeons.

Of the 11 patients who had an arthroscopy, 4 were told that they had an ACL injury. None of the 15 who had an MRI scan were told that they had an ACL injury.

Conclusion: Despite the increasing incidence and changes in management, there appears to have been very little improvement in the detection of the ACL injured knee in the last 10 years.


S A Jain J Rollo A L Pimpalnerkar

A review of the outcome, safety, practicality and cost effectiveness of day surgery anterior cruciate ligament (ACL) reconstruction was studied in the British set-up.

From January 2003 to May 2005, 75 patients who underwent day case arthroscopic ACL reconstruction without the use of tourniquet or nerve blocks, but using a pump-regulated saline-epinephrine irrigation system were studied prospectively. 68 patients had a hamstring tendon graft and 7 patients had patellar tendon graft reconstruction. None of the patients required overnight stay. Mean immediate postoperative Visual Analogue Score (VAS) for pain was 2.5 (range1–8) and 0.5 (range 0–3) at 6 weeks indicating excellent pain control. The mean follow-up was 14 months (range 6–30 months). We had no early or late complications in this series. ACL specific Mohtadi Quality of Life Index improved from pre-operative score of 20 (15–40) to 93 (80–100) at 9 months after surgery. The mean Modified Lysholm Knee Score was 93.9 points, (range 80–100) at the 9 months follow-up examination. On Tegner activity score, 68 patients returned to the same level of sporting activity at 8 months and the rest 7 patients dropped 1 level. The average saving per patient was in the range of 50–60% when compared to inpatient ACL reconstruction.

In conclusion, day case ACL reconstruction using a pump-regulated saline-epinephrine irrigation system is safe, cost-effective and is the patient’s choice.


S Patil V Kumar V Kamath L White J Dixon A Hui

Introduction: Poor proprioception and imbalance between quadriceps and hamstrings have been suggested as causes for anterior knee pain. The aim of our study was to compare the proprioception of patients with anterior knee pain to a normal population and to compare the activity of quadriceps and hamstrings using electromyography (EMG) in the 2 groups.

Methods: Patients and controls between the ages 11–25 yrs were recruited into the study. The proprioception (stability index) of the patients and controls was tested using the Biodex stability system. This computerised system tests the ability of a person to balance his/her own body on a platform that moves in various directions. Surface EMG was recorded from the quadriceps and hamstrings during this test. EMG was also recorded as the patients and controls stepped onto a 20cm step. EMG activity was normalised to levels elicited during maximal isometric contractions.

Results: 18 patients and 27 controls were recruited.

We found no significant difference between the groups in the EMG intensity of vastus lateralis relative to biceps femoris, or vastus medialis relative to vastus lateralis, during the balance test or during the step up task (Mann Whitney U test all p> 0.05). We did not find any difference in the proprioceptive abilities of the two groups

Conclusion: We found no significant difference between the groups in the intensity of muscle contraction of the hamstrings relative to the quadriceps, i.e. no evidence for an imbalance in the patients. However the temporal relation between the two needs further investigation.


J R Robinson L Carat C Granchi P Colombet

Cadaveric experiments using knee testing machines have suggested that anatomical ACL reconstruction, replacing both antero-medial (AM) and postero-lateral (PL) bundles, restores knee rotation kinematics more effectively than does a single-bundle. The aim of this study was to measure intra-operatively the control of the translation and coupled rotations that occur with standard clinical laxity tests (anterior drawer, Lachman and pivot shift).

The knee kinematics of 10 patients were measured using a surgical navigation system and described in terms of tibial axial rotation and antero-posterior translation. In the ACL deficient knee, the average maximum tibial rotation during the pivot shift test was 29.0° and the mean maximum translation 17.0 mm. Reconstruction of the AM bundle (which behaves in a biomechanically similar way to a single-bundle reconstruction) reduced the rotational component to 16.4° (p< 0.0001) and translation to 6 mm (p = 0.0002). Addition of the PL bundle further reduced rotation to 12.6° (p = 0.0007) but had no significant effect on translation. Addition of the PL bundle also significantly reduced coupled tibial internal rotation during the Lachman and Anterior draw tests.

The pivot shift test simulates the instability suffered by patients with ACL deficiency and this study suggests that its rotational component is better restrained by anatomical, 2 bundle ACL reconstruction.


T Nguyen S Apsingi AMJ Bull A Unwin DJ Deehan AA Amis

Aim: To compare the ability of two different PLC reconstruction techniques to restore the kinematics of a PCL & PLC deficient knee to PCL deficient condition.

Methods: 8 fresh frozen cadaver knees were used. A custom rig with electromagnetic tracking system measured knee kinematics. Each knee was tested with posterior & anterior drawer forces of 80N, external rotation moment of 5Nm & varus moment of 5Nm when intact, after dividing PCL, PLC (lateral collateral ligament & popliteus tendon), after PLC reconstruction type1 (1PLC) & PLC reconstruction type 2 (2PLC). 1PLC was modification of Larson’s technique with semitendinosus graft. 2PLC was performed with semitendinosus graft to reconstruct the lateral collateral ligament & the pop-liteofibular ligament, gracillis used to reconstruct pop-liteus tendon.

Results: The one-tailed paired student’s t test with Bon-ferroni correction was used to analyse the data. Only in deep flexion 2PLC reconstruction was significantly better than the 1PLC reconstruction in restoring the posterior laxity to PCL deficient condition (p=0.02). (Figure1) In deep flexion 1PLC could not restore the rotational laxity to PCL deficient condition (p=0.02). In mid flexion the 2PLC was unable to restore the rotational laxity to PCL deficient condition (p=0.048) (Figure 2).

Conclusion: The 2PLC reconstruction was better than the 1PCL in controlling the posterior drawer. The 1PLC technique though not significant tended to over constrain the external & varus rotations.


F Muir S H Palmer D Hollinghurst T Theologis

Purpose of Study:

To describe the degree and type of disability experience by patients with combined postero-lateral corner and posterior cruciate ligament knee injuries

To document any dynamic abnormalities of the lower limbs through the gait cycle using kinematic and kinetic gait analysis

To identify abnormal electromyographic signals of the quadriceps, hamstring and gastrocnemius muscles through normal gait.

Methods and Results: After rigorous exclusion criteria were instituted twelve patients were identified as having the required combined knee ligament injuries. These patients underwent functional assessment, clinic examination and gait analysis at the Oxford Gait Laboratory.

Significant functional disability was noted in all patients. Characteristic gait abnormalities identified included hyperextension and dynamic varus deformity with a corresponding increase in the internal valgus knee moment. Electromyographic data revealed early and prolonged contraction of the medial hamstrings and gastrocnemius muscles.

Conclusion: These results suggest the presence of compensatory mechanisms of the musculature around the knee and suggest direction in rehabilitation programs in patients with combined injuries to the posterior cruciate ligament and posterolateral corner of the knee. The results also provide baseline data that will be useful when evaluating the post-operative outcomes in patients undergoing knee ligament reconstruction in the future.


V Khanduja H S Somayaji M Utukuri G Dowd

Objective: The aim of this study was to assess the results of combined arthroscopically assisted posterior cruciate ligament reconstruction and open reconstruction of the posterolateral corner in patients with chronic (3 months or more) symptomatic instability and pain.

Patients & Methods: A retrospective analysis of all the patients who had a combined reconstruction of the posterior cruciate ligament and the posterolateral corner between 1996 and 2003 was carried out. Nineteen patients who had the combined reconstruction were identified from the database. All the patients were assessed pre and post-operatively by physical examination and three different ligament rating scores. All the patients also had weight bearing radiographs, MRI scans and an examination under anaesthesia and arthroscopy pre-operatively. The PCL reconstruction was performed using an arthroscopically assisted single anterolateral bundle technique and the posterolateral corner structures were reconstructed using an open Larson type of tenodesis.

Results: Pre-operatively all the patients had a grade III posterior sag and demonstrated more than 20 degrees of external rotation as compared to the opposite normal knee on the Dial test. The average follow up was 66.8 months (range 24–108). Post-operatively 7 patients had no residual posterior sag, 11 patients had a grade I posterior sag and 1 patient had a grade II posterior sag. Five of the 19 patients demonstrated minimal residual posterolateral laxity. The Lysholm score improved from a mean of 41.2 to 76.5 (P=0.0001) and the Tegner score from a mean of 2.6 to 6.4 (p=0.0001).

Conclusions: We conclude that while a combined reconstruction of chronic posterior cruciate ligament and pos-terolateral corner instability does not restore complete anatomical stability, improvement in symptoms and function demonstrate its value in these difficult injuries.


M A Yaqoob D Baiju R Chauhan G Geutjens

The aim of this study was to evaluate the functional and clinical outcome following medial patello-femoral ligament reconstruction using autogenous hamstring tendon grafts for patellar instability.

Over a 4 year period the senior author operated on 35 patients for lateral instability of the patella. The predominant initiating event was a sporting injury. Patients were evaluated clinically and functionally. The Fulkerson score was utilised pre and post operatively. The minimum follow up was 6 months, the mean follow up was 20 months. There were 18 males and 17 females. The mean age was 24.6 years. The mean pre-operative Fulkerson score was 59.3(range 6–100). The mean post operative Fulkerson score was 83.6(range 25–100), the mean improvement was 24.3.

24 patients returned to sporting activities

The main complications was one patient with a patella fracture that was stabilised with internal fixation, one patient requiring exploration and reinforcing the ligament which had attenuated. Both patients finally had a good clinical outcome.

Our study has shown that symptomatic lateral instability of the patella can be effectively treated with a medial patello-femoral ligament reconstruction and result in overall good clinical and functional outcome.

We would recommend this technique


S Shakkor A Aldairy K Adra

Purpose: the purpose of this study was to evaluate the outcome of arthroscopic repair of the medial patello femoral joint capsule (MPFJC) and its supporting structures in traumatic patello femoral instability (TPFI).

Type of study: prospective case series.

Material and methods: 24 patients 15 male and 9 female with traumatic patello femoral instability (TPFI) were treated with arthroscopic repair of the medial patello femoral joint capsule regardless of the injury chronology using 2/0 vicryle stitches by outside-in technique lateral release were not required, average age at the operation was 23,2 years (range 20–26) with 1 patient was 33, average time from injury to operation 3mounths (range 1–8 months) with 1 patient had the injury for 3 years.

The patients evaluated at 10 days, 3 weeks, 6 weeks, 3 months and every 3 months afterward up to 1 year. Average follow up was 9,3 months (range 3–12mounths).

Subjective data were calculated using the IKDC system, objective data included a comprehensive knee examination and evaluation and comparing it with normal side, which was used as a reference.

Results: at the final review all patients were satisfied with their knees, the IKDC final score improves from 54pre op to 93.

There has been no recurrence of the instability or tenderness around the knee, nil infection rate, normal side-to-side movement of the patella comparing with normal side, full range of motion, and normal quadriceps belly and strength.

The patient returned to light sports activities at 6 weeks, and to their pre injury level of sport at 3 months.

Conclusion: we feel that our approach to treat TPFI is a reliable, safe, and cost effective. Our results are encouraging, although we feel that longer follow up might be required.


S Apsingi T Nguyen AMJ Bull DJ Deehan A Unwin AA Amis

Aim: To analyse the posterior and external rotational laxities in single bundle PCL (sPCL) and double bundle PCL reconstruction (dPCL) in a PCL and PLC deficient knee.

Methods: Ten fresh frozen were used. A custom made wooden rig with electromagnetic tracking was used to measured knee kinematics. Each knee was tested with posterior and anterior drawer forces of 80N and an external rotation moment of 5Nm when intact, after PCL resection, after dividing the PLC and after performing dPCL and sPCL reconstructions with a bone patellar tendon bone allograft and tibial inlay technique.

Results: The one-tailed paired Student’s t test with Bon-ferroni correction was used. There was a significant difference between the ability of the dPCL and sPCL reconstruction to correct the posterior drawer in extension (p=0.002). There was no difference between the dPCL reconstruction and the intact condition of the knee near extension (p=0.142, Fig 1). There was no significant difference between the intact condition and both sPCL (p=0.26) and dPCL (p=0.20) reconstructions in flexion in restoring posterior laxity. Neither of the reconstructions could restore the rotational laxity (Fig 3).

Conclusion: In a combined PCL and PLC deficient knee the posterior laxity can be controlled by both the sPCL as well as the dPCL reconstructions except near extension where the dPCL reconstruction was better.


V Ramasamy S C Halder

Periprosthetic fractures around Total Knee Arthroplasty are potentially devastating complication to both the patients and the surgeons. The reported prevalence of supracondylar femoral fractures following Total Knee Replacement has ranged from 0.3 to 2.5 percent. The complication rates of various treatment modalities reported in literature varies from 25 to 70 percent.

Aim: The purpose of this study is to evaluate the outcome of Antegrade Nailing and Wire fixation in Supra-condylar femoral periprosthetic fractures.

Material & Methods: Seven patients who sustained complex distal femoral fractures above Total Knee Arthroplasty all treated by New technique of Ante-grade intramedullary Nailing and intramedullary bi-wire fixation through greater trochanteric approach without opening the distal femur were retrospectively evaluated.

Results: All the patients demonstrated uncomplicated postoperative follow-ups and returned to weight bearing between 2 and 3 months. The average age of patient was 70 (55–90) years. All fractures healed in a satisfactory alignment in average duration of 12.6 weeks. There was no wound infection, loss of reduction or implant failure. The average range of movement of knee was 86 degrees.

Conclusion: The Antegrade Nail with Wires is a simple & effective method of treating displaced periprosthetic fractures proximal to Total Knee Arthroplasy. This involves less soft tissue dissection, less operative time and satisfactory bony healing even in poor quality bones while maintaining adequate range of movements of the knee.


SP Krishnan JA Skinner J Jagiello RWJ Carrington AM Flanagan TWR Briggs G. Bentley

Aim: The aim of this study was to correlate the histology of cartilage repair site with long term clinical function.

Materials and methods: We have analyzed the clinical results of a cohort of patients who had collagen-covered autologous chondrocyte implantations performed since 1998. Our hypothesis was that the hyaline cartilage repair does influence the clinical outcome.

The modified Cincinnati scores (MCRS) of eighty-six patients were evaluated prospectively at one year and at the latest follow-up following ACI-C (mean follow-up= 4.7 years. Range= 4 to 7 years). All these patients underwent biopsies of their cartilage repair site performed at variable periods between six months and five years following ACI-C (mean=22.2 months). The neo-cartilage was graded as hyaline (n=32), mixed fibrohyaline (n=19), fibrocartilagenous (n=35) and fibrous (n=0).

Results: The clinical results showed that at one year, the percentage of patients with excellent and good results was 84.4, 89.5 and 74.3 respectively for those with hyaline, mixed fibro-hyaline and fibro-cartilagenous histology respectively. Their mean MCRS were 70.8, 72.4 and 66.2 respectively. This difference was not statistically significant (p=0.34).

However, their clinical scores at the latest follow-up demonstrated a significantly superior result for those with hyaline repair tissue when compared to those with mixed fibro-hyaline and fibro-cartilagenous repair tissue (p=0.05). The percentage of patients with excellent and good results for those with hyaline, mixed fibro-hyaline and fibro-cartilagenous repair was 75, 42 and 68.6 respectively. Their mean MCRS were 70.6, 56.8 and 63.9 respectively.

Conclusion: This study demonstrates that any form of cartilage repair would give good clinical outcome at one year. At four years and beyond, it appears that patients with hyaline repair tissue tend to show a more favourable clinical outcome whereas those who demonstrated mixed fibrohyaline and fibrocartilagenous repair would show less favourable clinical results.


BA Rogers Mr Carrington Mr Skinner Bentley TWR Briggs

Introduction: The treatment of distal femoral cartilage defects using autologous chondrocyte implantation (ACI) and matrix-guided autologous chondrocyte implantation (MACI) is become increasingly common. This prospective 7-year study reviews and compares the clinical outcome of ACI and MACI.

Methods: We present the clinical outcomes of 159 knees (156 patients) that have undergone autologous chondrocyte implantation from July 1998. One surgeon performed all operations with patients subsequently assessed on a yearly basis using 7 independent validated clinical, functional & satisfaction rating scores.

Results: Modified Cincinnati, Patient Functional Outcome and Lysholm & Gilchrist clinical rating scores all showed significant improvements compared to pre-operative levels (p< 0.0001). Although ACI scores are superior at one year (p< 0.05) there is no significant difference between ACI and MACI at 2 years.

Visual Analogue Score and Bentley Functional rating score showed significant improvements compared to pre-operative levels (p< 0.0001) with ongoing yearly sequential improvement.

Patient Rating and Brittberg scores, both subjective patient scores, similarly showed continuing improvements in the years following surgery.

Discussion: ACI and MACI produce significant improvements in knee function when compared to pre-operative levels with continued sequential improvement in outcomes for up to seven years. The initial data suggests a superior rate of clinical improvement using the MACI technique


V. Kumar A Panagopoulos J K Triantafyllopoulos L van Niekerk

Background: The medial patellofemoral ligament (MPFL) is the principle medial stabilizer of the patella. It is damaged after traumatic patella dislocation. We describe a reproducible technique for MPFL reconstruction and our preliminary results at 12 months.

Material-methods: 25 patients (19 men, 6 women; average age 26.9 years-old) with post-traumatic patellar instability underwent MPFL reconstruction at a mean post-injury interval of 22.3 months. Five patients had evidence of generalized laxity, 3 had trochlear dysplasia and 16 (64%) more than two episodes of dislocation. Arthroscopic assessment revealed associated chondral lesions in 88% and marked lateralization. The reconstruction was performed using ipsilateral semitendinosus tendon. With the distal attachment preserved, the proximal end is passed through the medial intermuscular membrane and secured to the medial border of the patella. Clinical pre- and post-operative assessments included IKDC, Tegner, Lysholm and Kujala scores. ICRS documentation recorded the contribution of articular cartilage damage, whereas Merchant views and MRI scans documented the abnormal radiological parameters and the damaged structures of the medial retinaculum respectively.

Results: At a mean follow up period of 12 months (8–18 months) no cases of re-dislocation were recorded. The Tegner and IKDC scores averaged 4.2 and 46.9 pre-injury. Postoperatively they had improved to 7.7 and 86.5. The average postoperative Lyshom- and Kujala scores were 87 and 89 respectively. Re-operation was required in one patient after patellar fracture 8 weeks post reconstruction.

Conclusion: Our preliminary results suggest surgical reconstruction of the MPFL provide a favorable early outcome for the treatment of post-traumatic patellofemoral instability and will form the basis for longer follow up in a larger cohort.


S Patil A Mahon I. McMurtry S. Green A. Port

Introduction: There is a recent trend of using a raft of small diameter 3.5 mm cortical screws instead of the large diameter 6.5mm screws in depressed tibial plateau fractures. Our aim was to compare the biomechanical properties of these two constructs in the normal and osteoporotic synthetic bone model.

Methods: 20 rigid polyurethane foam blocks with a density simulating osteoporotic bone and normal bone were obtained. A Schatzker type 3 fracture was created in each block. The fracture fragments were then elevated and supported using 2, 6.5mm cancellous screws or 4, 3.5mm cortical screws.

The fractures were loaded using a Lloyd’s machine and a load displacement curve was plotted.

Results: Osteoporotic model. The mean force needed to produce a depression of 5mm was 700.8N with the 4-screw construct and 512.4N with the 2 screw construct (p=0.007).

Non-osteoporotic model. The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct (p=0.42).

An increased fragmentation of the synthetic bone fragments was noticed with the 2-screw construct but not with the 4-screw construct.

Conclusion: A raft of 4, 3.5 mm cortical screws is biomechanically stronger than two, 6.5mm cancellous screws in resisting axial compression in osteoporotic bone.


WS Khan R Jones L Nokes DS Johnson

Introduction: In this study the optimal angle of fixation or splintage for partially weight bearing fractures of the patella was determined by a gait analysis measurement system.

Subjects and Methods: A knee brace was applied to eight subjects and locked at 0, 10, 20 and 30 degrees. Measurements were also taken for an unlocked brace and in the absence of a brace. The subjects were instructed on partial weight bearing mobilisation. Three dimensional motion analyses were performed using an infrared 8-camera system. The ground reaction force was recorded by two 3-dimensional force plates embedded in the walkway. Kinematic and kinetic data was collected and the data was transferred to a computer programme for further analysis and the forces acting on the patella were calculated.

Results: The results showed that the forces acting on the patella were directly proportional to the knee flexion angle. The results also showed that the knee flexion angle does not always correspond with the angle set at the knee brace; however they did exhibit a direct relationship.

Conclusion: Our findings show that, for partially weight bearing patella fractures, the optimum form of splintage corresponds with a low knee flexion angle.


MP Jackson H Cottam A Butler-Manuel H Apthorp

AIMS: To compare a randomised group of patients undergoing UKA to investigate the advantages of the minimal invasive approach in the early post-operative stage.

METHODS & RESULTS: 100 patients on the waiting list for UKA were recruited into the trial. Patients were randomised into 2 groups: Group 1 – longitudinal skin incision with dislocation of the patella, Group 2 – the minimally invasive approach. Standard milestones were recorded post-operatively: time to achieve IRQ, independent stair climbing and to discharge. Additionally, patients were scored with the AKSS and Oxford knee questionnaire pre-operatively, at 6 weeks, 6 months and 1 year.

No significant differences were found between the 2 groups in the measured parameters.

CONCLUSION: To our knowledge, there has been no previous randomised trial to investigate the results of less invasive surgery for UKA. We have been unable to demonstrate a significant advantage of this approach. With the continued drive for early return to function, some centres incorporate a 24hr accelerated discharge protocol. The less invasive approach may make this more achievable. We recommend however that the surgical procedure and implant position must not be compromised for the benefit of rapid discharge to the deficit of long term results.


WS Khan DS Johnson JG Andrew TE Hardingham

Introduction: In this study infrapatellar fat pad (IPFP) derived stem cells were expanded with and without Fibroblast Growth Factor-2 (FGF-2) supplementation and were compared with regards to their ability to proliferate and differentiate into chondrocytes.

Materials and Methods: Cells were isolated from the IPFP tissue and expanded in monolayer culture with and without rhFGF-2 supplementation (final concentration 10ng/ ml). Cell aggregates were placed in chondrogenic media for two weeks. Gene expression studies were carried out using quantitative real time PCR. Immunohistochemical labelling was performed with antibody localisation determined by an immunoperoxidase procedure. The pellets were also weighed and digested in papain for DNA and glycosoaminoglycan (GAG) analysis.

Results: Cells expanded in FGF-2 supplemented media were smaller and proliferated more rapidly. The FGF-2 supplemented cell aggregates also showed 100 times higher expression of collagen type II (COL2A1). Immunohistochemical studies showed that pellets made from FGF-2 treated cells stained more strongly for collagen II and more weakly for collagen I. Pellets made with FGF-2 treated cells were larger, continued with enhanced proliferation and contained more proteoglycan.

Conclusion: Our findings show enhanced proliferation and chondrogenic differentiation in IPFP derived stem cells expanded in FGF-2 supplemented media.


V Kumar A Panagoupolous J K Triantafyllopoulos L van Niekerk

Background & Aim: Recent studies have claimed good results after ACI in athletes. Our aim was to evaluate the early functional outcome and activity level after 2-stage ACI in professional athletes and soldiers.

Methods: Thirteen soldiers and five professional athletes (14 men and 4 women; average age 31 years), with 21 full thickness cartilage defects (ICRS grade-IV) of the knee were treated with 2-stage ACI. Mean interval between injury and surgery was 43.8 months. Average defect size was 6.03 cm2 and was located to the MFC in 7 cases, LFC in 7 cases and the femoral trochlea in one case. The functional outcome was evaluated with ICRS form, Tegner activity rating scale and Lysholm score after a mean follow up period of 23.4 (18–32) months.

Results: The ICRS and Lysholm scores were improved from 42.7 and 47.6 pre-operatively to 63.1 and 69.9 respectively. The average Tegner scale was 8.8 pre-injury, 3.7 prior to surgery and 6.4 at the final follow up. Nine patients (50%) underwent second-look arthroscopy for persistent mechanical symptoms. Periosteal flap overgrowth was identified in 6 cases with adequate graft integration while partial failure of the graft was noted in one case and was treated with microfracture.

Conclusions: The early results of ACI in high-performance athletes and professional soldiers are not as good as other studies suggest. Returning to pre-injury performance levels for athletes and military people is by no means assured in the first 24 months after ACI.


MC Forster A Bauze G Keene

The aim of this prospective cohort study is to compare the early results in a single surgeon series of the mobile and fixed bearing versions of the Preservation UKR for lateral OA. Lateral UKRs were only considered for patients with isolated lateral compartment osteoarthritis with a functioning anterior cruciate ligament. Mild patellofemoral osteoarthritis was not considered a contraindication. If there was any doubt over the condition of the medial compartment or patellofemoral joint, single photon emission computed tomography was performed. Significant uptake it the medial or patellofemoral joint was considered a contraindication. Patients were assessed preoperatively and at 1 and 2 years postoperatively with the American Knee Society Score (AKSS), Oxford Knee Score (OKS) and with anteroposterior, lateral and Rosenberg radiographs.

Between 29th May 2001 and 15th May 2003, the senior author (GK) performed 233 consecutive Preservation UKRs. Of these, 30 were lateral UKRs (13%) performed in 12 men and 16 women (2 bilateral cases) with a mean age of 67 years (range 36 to 93 years). A metal-backed mobile bearing tibial component was used in 13 knees and an all-polyethylene fixed bearing tibial component in 17 knees. Patients in the mobile bearing group were significantly younger (t test; p< 0.0001) and had better AKSS knee (Mann-Whitney U test; p=0.05) and AKSS function scores (Mann-Whitney U test; p=0.005). The patients were reviewed after a minimum of 2 years (range 2 to 3.4 years). There was no significant difference between the 2 groups. There had been 3 revisions in the mobile bearing group for tibial loosening and none in the fixed bearing group (chi squared test; not significant). There was 1 tibial periprosthetic fracture in the fixed bearing group. This study shows that the choice of bearing type makes little difference in clinical outcome or range of motion over the first 2 years when using the Preservation Knee. A similar good functional result was obtained with a fixed bearing despite the mobile bearing group being younger and having significantly better preoperative AKS knee and function scores. The 3 revisions for tibial loosening in the mobile bearing group are a concern. However, these results are short-term and there may be improved implant longevity in the long-term with mobile bearing tibial components due to reduced polyethylene wear.


C E Ackroyd J H Newman R Evans C C Joslin

Objective: To review the results of the Avon patellofemoral arthroplasty at 5 to 8 years.

Methods: The Avon patellofemoral arthroplasty was introduced in clinical practice in September 1996. We present a prospective cohort review of all patients treated in the first three years. Patients were evaluated using the Bristol knee score (BSK), the Melbourne patella score (MPS) and the Oxford knee score (OKS).

Results: 109 patellofemoral arthroplasties were performed in 92 patients between September 1996 and November 1999. The median age was 68 years (range 46 to 86 years). Nine patients (12 knees) died and two patients (two knees) were unfit for follow-up. Ten knees in 9 patients were lost to follow-up giving a follow-up rate of 89%. The mean period of follow-up was 5.6 years.

The median pain score rose from 15/40 pre-operatively to 40 points at eight years. The median (MPS) rose from 10/30 points pre-operatively to 25 points at eight years. The median (OKS) rose from 18/48 pre-operatively to 38 at eight years. 87% of knees had mild or no pain at eight years. There were no cases of failure of the prosthesis itself. All 15 revisions resulted from progression of arthrititis in the tibio-femoral joint. The five-year survival rate for all causes with 86 cases at risk was 96%.

Conclusions: The results show that this type of arthroplasty can give predictable pain relief and excellent functional improvement in patients with isolated patello-femoral arthritis. Disease progression is the main reason for revision to total knee replacement and great care is required in assessing the indications for this procedure.


R G Steele J H Newman S Hutabarat R Evans C E Ackroyd

Purpose of Study: Fixed bearing unicompartmental knee replacement (UKR) has become popular since several series have shown good 10 year survivorship and excellent function. However little is known about survival during the second decade.

Method: From the Bristol database of over 4000 knee replacements 203 St. George Sled UKR’s which had already survived 10 years were identified. The mean age at surgery was 67 years (48–85), with 64% being female. This cohort has been further reviewed at an average of 14.8 years (10–30) from surgery to determine survivor-ship and function.

Results: Survivorship during the second decade was 87.5%. 58 patients (69 knees) had deceased with implant in situ, only 2 after revision. A further 15 UKR’s have been revised at an average of 13 years post op; 7 for progression of disease, 4 for tibial loosening, 3 for polyethylene wear, 2 for femoral component fracture and 2 for infection.

99 knees were followed for 15 years and 21 knees for 20 years. The average Bristol knee score of the surviving knees fell from 86 to 79 during the second decade.

A previous study showed an 89% 10 year survivor-ship and this is now extended to 82% at 15 years and 76.5% at 20 years.

Conclusion: Satisfactory survival of fixed bearing UKR can be achieved in the second decade suggesting that the indications for mobile bearings require careful definition since there is a higher incidence of complications in many people’s hands.


P. Thornton-Bott L. Unitt D.J. Johnstone A. Sambatakakis

Introduction: Soft tissue balancing is an important factor in the success of TKA, but if extensive may necessitate the use of thicker tibial inserts with the risk of creating a Pseudo-patella baja (PPB), which describes narrowing between the patella and the tibia without shortening of the PT, and occurs when the tibial prosthesis plus insert are thicker than the resected tibia.

Hypothesis: Patients who undergo extensive soft tissue releases during TKA, with resultant use of thicker tibial inserts will develop a PPB, with increased risk of patella pathology.

Method: 506 patients aged 40–90 years underwent 526 Kinemax TKAs, between 1999 and 2002. The extent of soft tissue releases and thickness of tibial inserts were recorded. Patella height was measured on pre and postoperative radiographs by an independent observer. Outcome was assessed using the Oxford Knee Score and the American Knee Society Clinical Rating System, with a minimum follow-up of 12 months.

Results:

TKA surgery creates a Pseudo-Patella Baja. PPB was introduced into 26.7% of patients. (p=0.000).

The incidence of pseudo patella baja increased with the extent of soft tissue release. (p=0.000).

The incidence of pseudo-patella-baja increased with increases in insert thickness. (p=0.035).

There was no correlation between the incidence of PPB and changes in outcome, as measured using the OKS and AKSS.

Conclusion: Pseudo patella baja occurs in 26% of all patients following TKA, and in 46% of patients in whom extensive soft tissue releases have been performed and/or large tibial inserts have been used. AT 12 months, no detrimental outcomes were attributable to the incidence of pseudo patella baja.


T D Clare J H Newman

Introduction: Following previously gratifying results in older patients the study aims to quantify the outcomes and identify any contraindications in patient selection for patello-femoral replacements using the Avon pros-thesis in patients under 55 years old.

Method: We present early outcome results for a prospective cohort study of patients under 55 years of age.110 knees in 86 patients (median age 47years, range 25–54) have been treated with Avon patello-femoral replacement (88 in females and 22 in males). Diagnoses included lateral facet OA (59 knees), patella dislocation (36 knees), trochlear dysplasia (39 knees) and post patellectomy instability (7 knees). 108 knees had undergone previous surgery. 14 knees required additional intra-operative procedures (including 11 lateral releases and 2 patella realignments). All patients were assessed pre-operatively using the Oxford, Bristol and WOMAC scores.

Results: No knees have been lost to follow-up. 82 knees have post operative scores available (mean follow-up 27 months). 8 have been revised (6 due to progression of OA). The mean Oxford, Bristol and WOMAC scores all improved: 18 to 32, 56 to 83 and 39 to 25 respectively. Asymptomatic deterioration of the tibio femoral joint is seen in some cases of primary OA but not with trochlear dysplasia. 21 knees required post-operative additional procedures including 6 lateral releases, 3 patella realignments and 5 revisions. Equally good results were seen when comparing patients with the 3 main diagnoses. Trochlear dysplasia is strongly predicted by young age at onset of symptoms and patellar dislocation.

Conclusion: Many of this type of patient, with disabling symptoms, wish to “live now”. The short-term improvements are frequently dramatic. Comparison of underlying pathologies has not identified groups that are performing less well to suggest restricting current indications. As yet there is no suggestion of prosthetic failure. Revision has presented little difficulty since minimal bone is resected primarily.


P J James P A May W Gerard Tarpey M Blyth I G Stother

Aim: The aim of the study was to assess the impact of a self aligning unidirectional mobile bearing TKR on lateral patella release rates within a knee system using a common femoral component for both the fixed and mobile variants.

Methods and Results: A total of 357 patients undergoing TKR were randomly allocated to receive either a Mobile Bearing (181 knees) or a Fixed Bearing (176 knees) PSTKR. Further sub-randomisation into patella resurfacing or retention was performed for both designs. The need for lateral patella release was assessed during surgery.

The lateral release rate was similar for fixed bearing (9%) and mobile bearing (9%) implants (p=0.95). Patella resurfacing resulted in lower lateral release rates when compared to patella retention (5.5% vs 13.5%; p=0.012). This difference was most marked in the mobile bearing group where the lateral release rate was 16% with patella retention compared to 3% with patella resurfacing (p=0.009).

Conclusion: The addition of a rotating platform tibial component has had no impact on the lateral release rate in this study. Optimising patella geometry by patella resurfacing appears more important than tibial bearing deisgn per se. The combination of a mobile bearing design and patella resurfacing appears the optimise patello-femoral tracking.


M M Kulkarni J D Eldridge J H Newman

Introduction: Anterior Knee pain is a very common presentation in Orthopaedic out patient clinics. However, Trochlear Dysplasia as a condition is still not very well understood.

Materials and Methods: Operative findings in patients undergoing Trochleaplasty and in young patients undergoing Patella-femoral arthroplasty were studied. Patients having trochlear dysplasia were identified. All these patients were sent a questionnaire to explore the variety of symptoms they experienced. 87 patients were identified for the study. 71(82%) patients responded to the questionnaire.

Results: Two subgroups were identified, one with dislocation of patella and the other without dislocation of the patella. Patients in patella dislocation group were younger (12 years vs 24) than those who presented without dislocation of patella. Patella dislocation group had more patients with anterior knee pain (71% vs 52%) as teenagers as compared to the group without dislocations. Symptoms such as giving way, lack of trust and unable to participate in sports were more commonly seen in the group with patella dislocation whereas, limited walking distance and difficulty with climbing the stairs were more commonly seen in the group without dislocation. Symptoms such as pain, catching and locking were seen equally amongst the two groups.

Conclusion: We believe that the patients with trochlear dysplasia have a bimodal presentation. Patients with dislocation of patella present earlier than those without patella dislocation. These two groups also have different symptoms at presentation. It is important to identify these subgroups correctly for appropriate management.


S H Zaki I Rafiq P J Rae

Purpose Of The Study: Description of a new operative technique of trochleoplasty for patellar instability and its short-term results.

Method: we report a new technique of trochleoplasty for Trochlear dysplasia, using Mitek anchor sutures. The purpose of the procedure is to remove the anterior femoral boss associated with Femoral Trochlear dysplasia and make the floor of the trochlea level with the anterior femoral cortex. The operation entails undermining of the trochlear and lateral condylar articular cartilage to a new corrected level where it is held with the use of No 2 Ethibond Mitek anchor sutures. These anchors are placed in the subchondral bone, suture needle passed through the articular cartilage and the sutures tied over it. Approximately 4 -5 anchor sutures are placed to hold the trochlear cartilage down to the new corrected level. This procedure can be combined with proximal and distal patellar realignment.

So far, using this technique, we have operated on six patients with trochlear dysplasia and chronic patellar instability. The patients include 4 females and 2 male with an average age of 33 yrs (range 29 – 40). Average follow up is 16 months (range 8 – 24 months). There has not been any recurrence of patellar instability in the operated patients.

Conclusion: Short-term follow up of a new operative technique of troachleoplasty for patellar instability shows promising results.


MC Norris D Beaver W. Schmidt M Kester SK Chauhan

Introduction: Contact stresses, derived from navigation system and conventional TKR alignments, are compared to ideally aligned component stresses.

Methods: This study builds upon the work of previous studies, in which post-operative CT scans from 70 patients were utilized to extract knee component angular alignments from patients undergoing both navigation based and conventional TKR. Knee component (Stryker Orthopaedics DuraconTM Condylar) FE models were oriented into specific alignment positions. Tibial insert contact stresses were computed under physiologically relevant loads at various flexion angles. FEA was also performed on ideally aligned cases for comparison purposes.

Results: At full extension, the median alignment of conventional TKR induces contact stresses 17.8% above ideal alignment conditions. Navigation based TKR alignment induces stresses 3.5% above ideal alignment conditions. At 45–90° flexion, conventional TKR alignment induces stresses 2.7% above ideal alignment conditions, while comparable navigation based TKR alignment induces stresses that match ideal alignment conditions.

Conclusion: Navigation based TKR procedures improve knee component alignment, which decreases contact stresses in UHMWPE tibial inserts. The result is a reduction in abnormal wear patterns and expected wear rates, with an increase in the structural longevity of knee system components.


S Dawson-Bowling K Chettiar R Hussein D East K Miles H Apthorp PA Butler-Manuel

Introduction: Debate continues regarding the optimal timing of surgery for patients requiring bilateral knee arthroplasty; we reviewed the costs, clinical and functional outcomes of 116 patients undergoing simultaneous or staged bilateral surgery using 3 different prostheses.

Method: Data were retrospectively collected from 116 consecutive patients undergoing 232 knee replacements over 10 years, either simultaneously or over 2 hospital admissions (staged). Post-operative complication rate, total cost of treatment (calculated from pros-theses, theatre time, days in hospital and number of clinic attendances) and functional (HSS) score at 1 year were the outcome measures.

Results: 54 patients underwent Oxford unicondylar knee replacements, 41 simultaneously, 13 staged; respective mean total costs were £9890 and £13,553 (p< 0.001). 42 patients were treated with AGC prostheses; 14 simultaneously, 28 staged, with respective total costs of £12,187 and £16,920 (p< 0.001). 10 TMK patients had simultaneous surgery (mean total cost £14,812), 10 were staged (£20,191); p< 0.001. For all 3 prostheses, there was no significant difference in complication rate or 1 year functional outcome between simultaneous and staged groups.

Discussion: Some authors advocate replacing both knees simultaneously as safe and cost-effective; others report significant increases in medical and surgical morbidity. Our series shows significant cost savings with no increase in complication rate.


S Hakkalamani V Prasanna A Acharya R Finley RW Parkinson

Stem dissociation in modular revision knee replacement due to failure of the frictional lock of the Morse taper has been reported in the literature. However, the medium and long-term implications of stem dissociation are unknown, as clinical outcomes have not been reported. We report a series of 10 cases in which there was intra-operative dissociation of the tibial stem.

Between 1994 and 1999, 98 patients underwent revision total knee replacement for aseptic loosening at our institution. Ten of these patients were noted to have tibial stem dissociation, apparent on the immediate post-operative radiographs. The senior author (RWP) performed all procedures and used a standardized operative technique. The Co-ordinate modular knee revision system was used in all cases. The quality of the bone was noted in all the cases intra-operatively; and was graded as 1) sound bone, 2) soft but intact, 3) soft and fractured cortex.

Our study demonstrates that the tibial stem dissociation did not cause any significant detriment to the clinical outcome on minimum follow-up of six years in nine cases where the tibial metaphyseal cortical rim was intact. In one case, where the medial tibial plateau had a cortical defect, the prosthesis drifted into varus mal-alignment and the patient required a further revision for aseptic loosening. We therefore question whether long canal filling tibial stems are necessary in all revision total knee replacements particularly when the cortical rim is intact and a non-constrained poly-ethylene insert is used.


R A E Clayton C R Howie P Gaston A C Watts

Aim: To investigate the incidence and type of venous thromboembolic event (VTE) diagnosed in patients undergoing total knee arthroplasty (TKA) and the trends over time following the introduction of a rigorously enforced thromboprophylaxis protocol.

Methods: Data from all 3260 TKAs performed in our unit between April 1996 and March 2003 were prospectively collected by the Scottish Arthroplasty Project (SAP). The SAP data identified 84 of these patients as having being admitted with or died from a VTE episode. A unified thromboprophylaxis protocol was introduced in 1999, from 2001 it was included as part of the integrated care pathway. We retrospectively reviewed all available casenotes of these patients to identify the assessment and thromboprophylaxis given, the precise diagnosis of VTE, the treatment and adverse outcomes.

Results: Of the 84 VTEs identified, 29 had pulmonary emboli (PE), 12 had above knee deep vein thrombosis (DVT), 24 had calf DVT and 10 had no evidence of VTE though were coded as such (but not treated) by physicians elsewhere. Data were unavailable for the remaining 9 but these were assumed to have had VTE for the purposes of this study. Of the 24 patients with calf only DVT, 16 were given therapeutic anticoagulation of whom five developed haemorrhagic complications. From 2001 the thromboprophylaxis protocol was followed in 100% of patients. The rate of VTE in our unit has fallen steadily from 2.26% in 1996–7 to 1.05% in 2002–3.

Conclusions: There has been a steady decline in the rate of venous thromboembolism in our unit over the seven years of the study. A thromboprophylaxis protocol has been successfully introduced in our unit and consistently applied since 2001. There is considerable overdiagnosis and treatment of calf DVT with significant resultant morbidity.


E Robinson PF Partington

Purpose: to quantify the cost of hospitalisation and theatre time in the treatment of infected primary total knee replacements.

Materials and Methods: hospital approval was obtained for the study. Inclusion criteria were defined as: patients requiring surgery for deep or superficial infection of a primary total knee replacement (TKR) with subsequent positive bacteriological cultures. Clinical coding provided a list of patients with the ICD 10 code T845 (infection or inflammatory reaction due to an internal joint replacement) over a 2 year period and notes of patients were obtained to confirm the inclusion criteria were met. The theatre procedures performed and numbers of days in hospital for all admissions related to joint infection were recorded. The cost of a day in hospital and the cost of each procedure by time in minutes were obtained from the hospital finance department hence the overall cost of hospitalisation and theatre per patient estimated.

Results: 15 patients were identified as having undergone surgery for an infected primary TKR. Prolonged hospital stay, predominantly for administration of antibiotics claimed the largest proportion of expenditure in our patient group. An average of 64 excess days per patient were spent in hospital (range 13 to 218). The cost of an overnight hospital stay is £180, therefore the cost per patient was £11544. Seven day procedures at a cost of £473 each were also carried out. Each patient underwent an average of 4.7 theatre procedures (range 1 to 12). The most common surgical procedures were joint washout / debridement for early infection, joint aspiration, first and second stage revision. The cost of a minute of theatre time is £12.97, hence the cost of theatre time per patient was £4959. The overall estimated cost per patient for treatment of an infected primary total knee replacement is £16503 (exclusive of implant and antibiotic costs).

Conclusion: the cost of an infected TKR is a substantial financial burden for trusts as well as a catastrophic complication for patients. Methods of reducing expenditure include reduction in hospital stay by administration of antibiotics by district nurses or trained family members, rapid management of early joint infection by washout and debridement with the possibility of avoiding revision surgery and explantation of components upon diagnosis of bone/cement interface infection hence avoiding futile operations.


M. Norris M Ather S Chauhan

Introduction: We investigated the routine use of CT scans in identifying alignment causes for failure as well as in the pre operative planning of the procedure.

Methods: Twenty poorly functioning total knee arthroplasties were analysed using the Perth CT protocol. All patients were awaiting revision total knee arthroplasty and were scanned using a GE multislice CT scanner. The measurements were performed using standard CT software. Knee society scores were obtained pre- and post-operative.

Results: The mean coronal position of the components was 3 degrees of valgus for the femoral component and 2.5 degrees of varus for the tibial component. Fourteen knees had errors of femoral component rotation, which ranged from 1 degree of external rotation to 9 degrees of internal rotation. Nine knees had errors of tibial baseplate rotation with all being internally rotated relative to the PCL/Tibial tuberosity axis from 3 to 12 degrees.

The cumulative error of implantation ranged from 6- 24 degrees in all 7 planes.

Knee society scores improved post-operatively from a mean of 52 pre-operatively to 83 at one year. Compound error also improved to a range of 6 to 10 in all 7 planes.

Conclusions: Revision total knee arthroplasty remains a difficult procedure but is increasing in frequency. The use of a CT protocol allows all coronal, sagittal and rotational errors of a previous implant to be accurately identified prior to surgery. We believe that all knee revision operations should have a CT scan as part of the pre operative planning. Also CT scans may be useful in investigating painful total knee replacements. Total knee replacement failure in some cases maybe explained by a cumulative error in alignment when no other obvious cause is found.


P J James P A May W Gerard Tarpey M Blyth I G Stother

Aim: This study aims to establish whether or not mobile bearing TKR delivers the often stated benefits improved function and range of motion when compared to its fixed bearing equivalent.

Methods and Results: A total of 357 patients undergoing TKR were randomly allocated to receive either a Mobile Bearing (181 knees) or a Fixed Bearing (176 knees) PSTKR. Further subrandomisation into patella resurfacing or retention was performed for both designs. All knees were scored using standard tools (Oxford, AKSS and SF12) preoperatively and at intervals postoperatively by independent observers.

The range of motion increased from an average of 96 deg. (pre-op) to an average of 109 deg. at 1 year post-op for both the fixed and mobile bearing design. The management of the patella had no effect in either group.

The knee society and knee function scores increased equally for both the fixed bearing and mobile bearing knees with no differences noted.

Conclusion: There were no measurable differences in range of motion and clinical outcome scores at 1 year post-op for a mobile bearing design over its fixed bearing equivalent. It is likely that any potential advantages of a mobile bearing design will manifest in longevity rather than function.


BA Rogers L Unitt SR Cannon TWR Briggs

Introduction: Predicting outcomes in the heterogenous population undergoing Total Knee Arthroplasty (TKA) is difficult. This prospective multi-centre study details the relationship between preoperative knee function and the sequential clinical and functional outcome progression of TKA.

Methods: Annual clinical and functional outcome scores (Oxford Knee Score & Knee Society Score) from 526 primary cemented Kinemax TKA implanted into 506 patients over a period of 3 years were assessed. Depending on preoperative knee function, patients were grouped into 3 cohorts: mild, moderate and severe.

Results: At one year there was a significantly (p< 0.05) greater improvement in Oxford Knee Score, Knee Society Score and range of movement in patients with severe preoperative knee function in comparison to the mild cohort. However, a significantly greater improvement (p< 0.05) in functional outcome was shown in patients with mild preoperative knee function.

Only patients with severe preoperative knee function showed deterioration in outcome measures from three years, all other patients maintained improvements.

Discussion: Severe, in comparison to mild, preoperative knee function predicts greater clinical but inferior functional improvement at one year, with deterioration in all outcome measures commencing from three years. Mild to moderate preoperative knee function affords ongoing sequential improvement in clinical and functional outcomes.


M Venkatesan SN Sambandam R Burman S Maxfield RC McGivney B Ilango

Introduction: Infection following TKR is a catastrophic complication. Few authors have highlighted the need for screening of patients (nose, axilla and groin) before TKR. Despite the fact that some of the centers in UK now routinely perform preoperative screening for TKR patients the overall incidence of surgical site infection in the year 2004 was 2.9%.

Methods and Materials: We introduced a new admission policy and SSI surveillance protocol for TKR patients in the year 2004 at our center. According to the new admission policy all TKR patients who were preoperatively screened were admitted into a clean elective ward. Care was taken not to admit anybody with positive infection screening in that ward, irrespective of the diagnosis. Further we also introduced a new policy of SSI surveillance according toNINSS protocol carried out by dedicated trained nurses.

Results and conclusions: Following the introduction of these policies our surgical site infection has come down to 0% in the year 2004–5 in contrast to 1.7% in the year 2002–3. These results showed that simple measures like having dedicated infection free clean wards and dedicated trained surveillance nurses can significantly reduce the infection rate following TKR


J Mutimer G Gillespie A Lovering A Porteous

The aim of this study was to measure intra-articular gentamicin levels at the 2nd stage revision following the use of an antibiotic impregnated articulating spacer.

Infected total knee replacements are a cause of considerable morbidity often requiring revision in two stages. Rings of bone cement, cement moulds and spacer devices are available for use following the initial debridement and removal of infected metalwork. The availability of antibiotic impregnated articulating spacers are potentially attractive to achieve a high local dose of antibiotic and to maintain a good range of movement.

Seven patients underwent a two stage revision of their total knee replacements. Following the initial debridement an antibiotic impregnated articulating spacer was cemented in place. At the 2nd stage revision a perioperative joint aspirate and blood sample was taken and gentamicin levels measured. The range of movement was assessed.

The average gentamicin levels were 0.72mg/l (0.24 – 2.36mg/l). A good range of movement was maintained in all cases. At these levels the gentamicin would be therapeutic.

Antibiotic impregnated articulating spacers possess several potential advantages to the revision knee surgeon by helping maintain the range of movement and provide local release of antibiotics. Their use should be considered in such cases.


B C Hanusch S Patil A Hui P Gregg

The aim of this study was to determine whether there is a difference in the functional outcome between fixed and mobile bearings in total knee arthroplasty.

120 patients were randomized (computer generated) to receive either a fixed or mobile bearing P.F.C. Sigma total knee replacement. 96 patients were needed to detect a 20° difference in range of motion (ROM) with a significance level of 0.05 and a test power of 0.97. Oxford knee score (OKS) and ROM were assessed independently before and one year after surgery.

Mean ROM and Oxford knee score before and at one year after surgery for both groups are shown as preliminary results for 70 patients (follow-up expected to be completed by March 2006):

There is no statistically significant difference in the mean ROM at one year and in change in ROM between the two groups (p=0.53 and p=0.21 respectively). The findings were similar for Oxford Knee Score at one year and change in Oxford Knee Score (p=0.45 and p=0.82). There was no early aseptic loosening in either group.

The one year results suggest that there is no significant difference in functional outcome measured as ROM and Oxford Knee Score between the two types of bearing. Further follow-up will be carried out to detect any differences in the long term outcome.


ML van der Linden PJ Rowe PA Roche P Gaston RW Nutton

Purpose: This study aims to explore the role of pain, fear of movement and learned helplessness on functional knee range of motion and daily functioning in a patients awaiting total knee arthroplasty (TKA)

Methods and results: Sixty-five patients (mean age 69 years old) with osteoarthritis were assessed an average of 37 days prior to TKA. Dynamic knee angle was measured during 11 functional activities including getting up from a chair and walking up and down a slope and stairs using flexible electrogoniometry. Function was assessed using the function components of the Knee Society Score (KSS) and the Western Ontario & McMaster University Osteoarthritis Index (WOMAC). Other self-report measures included the 8 item Tampa scale for kinesiophobia to assess ‘activity avoidance’ (TSK-AA), and the 5 item Helplessness subscale of the rheumatology attitudes index.

The pain component of the WOMAC was negatively associated with the knee angle during sitting down and getting up from a low chair and stepping in and out of a bath (r=0.40–0.45), but not with the peak knee angle during ascending and descending a slope or walking speed. Higher scores of the activity avoidance and the helplessness scales however, were associated with reduced knee angles during descending a slope and a slower walking speed (r=0.31–0.38). Both psychosocial scales were also associated with function (r=0.39–0.45). Another important finding was that activity avoidance was not associated with pain.

Conclusions: Not only pain but also fear of movement and learned helplessness play a role on specific components of knee function in patients with final stage osteoarthritis of the knee. Further research into the impact of pain and psychosocial variables on functional outcome in ostearthritis is indicated.


MD Horwitz S Awan MB Chatoo DJ Stott DP Powles

Background:Mobile bearing knee arthroplasty is an alternative to a fixed bearing knee arthroplasty, we present the results of a retrospective study of a fully congruent, multi-directional mobile bearing knee with a tibial post: the Rotaglide Total Knee System.

Methods: Patients were clinically and radiologically assessed at dedicated follow up clinics. The Hospital for Special Surgery (HSS) and Knee Society Score (KSS) systems were used to describe the clinical and radiological findings. The results were analysed by an independent statistician.

Results: The study group included 88 knees. The Prosthesis had a survival rate of 93,5 % at nine years. It is associated with good rates of patient satisfaction and high scores on the HSS and the KSS System. No knees were revised for aseptic loosening.

Conclusions: This, fully congruent, multidirectional mobile bearing knee replacement has survival equivalent to other prosthesis. It is a safe, reliable prosthesis associated with good clinical outcome.


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D S Damany S Hull M L Sutcliffe

Aim: To assess patient and surgery related factors to identify any trend leading to a stiff TKR. We also looked at the efficacy of MUA in the treatment of a stiff TKR.

Material and Methods: Retrospective analysis of TKRs which have undergone MUA during the period from 01/01/1999 to 25/06/2005 at Peterborough Hospitals. We included primary TKRs with a minimum post MUA follow-up of six months.

Results: Out of a total of 1809 TKRs, 42 TKRs (2.3%) in 38 patients required MUA. 26 (68%) were females with a median age of 67 years and a median BMI of 30. 34 (81%) had varus knees. Median pre-operative flexion was 100 deg. Median follow-up was 12 months (6 – 45 months). Median pre MUA flexion was 70 deg (15 – 100 deg.). Median surgery to MUA interval was 12 weeks (range: 10 days to 104 wks). Median gain in flexion during MUA was 35 deg (0 – 90 deg). At final follow-up, 74% had lost flexion gained at MUA (median loss: 17.5 deg, mean loss: 20 deg). 71% gained a median of 20 deg flexion with MUA (Mean: 25 deg, range: 15 – 85 deg). Median range of flexion at final follow-up was 90 deg (40 – 120 deg).

Conclusion: We were unable to identify any distinct trends in relation to BMI, pre op flexion, other patient or surgical factors that would help predict occurrence of a stiff TKR. We advocate the use of MUA for a stiff TKR. 71% patients gained 20 to 25 deg flexion with MUA. 74% patients lost about 20 deg flexion gained at MUA. The average post MUA flexion at final follow up was 90 deg. This information is useful when counselling patients undergoing MUA. A protocol for management of stiff TKR is suggested.


S Hakkalamani A Acharya A Carroll R Finley NJ Donnachie

The aim of this study was to evaluate whether using a predetermined entry point and standard value for valgus cut could restore normal mechanical axis of the TKA.

The study included 125 consecutive patients, who underwent TKA under care of the senior author (NJD). Details of height, weight, BMI were noted. All the radiographs were taken with the patient standing, with the knees in maximum extension, with the patella facing forward. The long leg radiographs were evaluated and the mechanical axis and anatomical axis were marked. The entry point (EP) and the angle between the anatomical and the mechanical axis of the femur ware measured, which is valgus angle of distal femoral cut (VA). Statistical analysis was done using SPSS (Table 1). Proportion of the cases with VA less than 6 degrees or more than 7 degrees were identified. Similarly cases with EP distance less than 0 and more than 5mms were also identified. Cases with VA of 6–7 degrees and EP 0–5mms were identified as one group. Correlation was performed using nonparametric tests.

The results revealed the angle between the anatomical and the mechanical axis ranges from 4 to 9.5 degrees (mean 6.8 degree and standard deviation 1.11 degree). Only 53% had an angle of between 6 and 7 degrees, with 7% of knees having an angle of less than 5 degree or greater than 8 degrees.

The site of entry of the jig showed variation from 30mms medial to the centre to 18mms lateral to the centre with the mean entry point of 5.04mms medial to centre of the notch, with a standard deviation of 8.5mms.

Overall only 33% of the knees templated would have an optimal femoral jig placement and distal femoral angle cut with an entry point in the centre of the notch or up to 5mms medial to centre and a distal valgus cut of between 6 and 7 degrees. The author feel this study gives evidence that if the mechanical axis is to be restored then long leg pre-operative radiographs should be performed and used as a key component to the pre-operative plan.

Table 1. Spearman’s rho correlations, between the valgus angle and entry point to the height, weight and BMI of the patients.


S Hakkalamani F A Carroll C Ford P Mereddy G Jefferies R W Parkinson

Background and objectives: Total knee replacement (TKR) produces severe postoperative pain. Peripheral nerve blocks can be used as analgesic adjuncts for TKR, but the efficacy of a sciatic nerve block as an adjunct to a femoral nerve block is controversial. The aim of this study was to compare femoral with femoral and sciatic nerve blocks in postoperative pain management of patients undergoing total knee arthroplasty (TKA).

Methods: 42 patients were involved in the study. 20 patients received only a femoral nerve block, consisting of 20ml of 0.5% Chirocaine and 22 patients received femoral and sciatic nerve blocks, consisting of 20ml of 0.375% Chirocaine for the femoral nerve and 10ml of 0.5% Chirocaine for the sciatic nerve. The primary outcome measures used were visual analogue scale (VAS) scores for pain at 24 hours, 48 hours and 72 hours after the surgery, opiates consumption post-operatively and PCA use. The secondary outcomes were post-operative nausea and vomiting, sensory deficit, quadriceps contraction, straight leg raise, knee flexion, independent mobility and discharge from the hospital.

Results: The results showed no difference in opiate consumption, PCA use, independent mobility and time of discharge from the hospital between the two groups.

Conclusion: The study shows that the addition of a sciatic nerve block to the femoral nerve block does not provide additional benefits.


M R Acharya C N A Esler W M Harper

Introduction: The functional outcome and survivorship of knee arthroplasty in young patients remains a concern. The aim of this study is to assess patient reported outcomes of knee arthroplasty surgery in osteoarthritic patients age 55 years old or younger in a generalist setting.

Patients and methods: All patients 55 years old or younger at the time of index arthroplasty were identified from the Trent arthroplasty register. Demographic data was available for all patients. A self-administered questionnaire was mailed to patients. This questionnaire included an Oxford Knee Score along with questions relating to employment, leisure activities and the patient expectations of their surgery.

Results: 242 patients 55 years old or younger had a knee arthroplasty in the study period (male:female 1:1). 208 patients had a total knee arthroplasty. The remaining had a unicompartmental knee replacement. Mean age of patients for the total knee arthroplasty group was 51 years (range 37–55) and that for the unicompartmental group was 50 years (range 37–55). The average length of follow up for the total knee arthroplasty group was 33.3 months (range 12–57) and that for the unicom-partmental group was 29.3 months (range 16–45). The average Oxford knee score at follow up was comparable between the two groups; 31.8 (range 12–57) for the total knee arthroplasty group and 32.0 (range 13–54) for the unicompartmental group. 77% of patients in the total knee arthroplasty group and 71% of patients in the uni-compartmental group reported that the pain relief was better or just as they expected following the operation.

Conclusion: Knee arthroplasty remains a satisfactory procedure in young patients under the age of 55 years. There is no significant difference in Oxford knee scores between patients that have total knee replacement or unicompart-mental knee replacement. Pain relief is better or just as expected in the majority of patients in both groups.


A V Papavasiliou D L Isaac R Marimuthu B Nurboja A Skyrme A Armitage

Objective: To assess the possible effect of intra-articular steroid injections to future TKA.

Materials-Method: We retrospectively studied all 231 patients who underwent AGC (Biomet) TKR in our hospital from February 2002 to October 2004. Twenty notes were not available in medical records and were excluded from the study. Other exclusion criteria were previous surgery (other than knee arthroscopy) on the affected site, a diagnosis of inflammatory arthritis, immunosu-pressed patients, a previous history of infection around the knee, smoking, diabetic patients. Applying these criteria we excluded a further sixty-seven patients.

The remaining 144 patients were separated in to two groups. Group I (n=54) consisted of those patients that received one or more recorded I/A steroid injections in their operated knee in an orthopaedic clinic, rheumatology clinic or general practice setting prior to surgery. Group II (n=90) consisted of those patients with no record of receiving an I/A steroid injection prior to surgery.

Results: We found that all the deep infections (3) were from Group I and had received an I/A steroid injection up to 11 months prior to surgery. The incidence of superficial infection was not significantly different from the control group (Group II).

In addition to those patients with confirmed deep infections, five patients underwent post-operative investigations for suspected deep infection, due to symptoms of persistent swelling or pain. All had received an I/A steroid injection pre-operatively.

The length of time between injection and subsequent post-operative infection leads us to speculate that the steroid agent might not fully dissolve, becoming trapped within the soft tissues or cystic areas of degeneration in the knee joint. Such steroids may become re-activated during operation, leading to catastrophic results. Indeed, there is experimental evidence to suggest an increased risk of infection with the intra-operative administration of steroids.

Conclusion: We conclude that the decision to administer intra-articular steroids to a patient who may be a candidate for knee replacement surgery should not be taken lightly because of a risk of post operative deep infection.


S Joshy B Thomas N Gogi A Mahale B K Singh

The aim of our study is to identify the organisms causing delayed deep infections following primary total knee arthroplasty in the current situation. We also compared the differences in outcome based on the infecting organism.

We undertook a retrospective study of all the patients who presented with delayed deep infection following primary total knee replacement during a six year period between April 1998 and March 2004. We analysed the infecting organism, sensitivity of the organism to antibiotics, number of surgical procedure carried out and the outcome of the infected arthroplasty based on the infecting organism. Statistical analysis was done using Fisher’s Exact test for categorical data and Mann-Whitney U test for the non-parametric numeric data.

The mean age at the time of primary arthroplasty was 69.9 years (range 46 to 92 years, SD=10.8). The mean follow-up (time since the initial knee replacement) was 77.3 months (range 27–170 months,). The mean follow-up since the last surgical procedure to treat infection was 31 months (range 14–47 months). Organisms were isolated in 27 of the 31 patients who presented with delayed deep infection. Forty-four % of the organisms isolated were multi-drug resistant with increasing incidence of Methicillin resistant Staphylococcus aureus and multi-drug resistant Staphylococcus epidermidis infections. Successful outcome following an infected total knee arthroplasty was lower compared to the previous studies where there were fewer multi-drug resistant organisms. The number of patients with satisfactory outcome is significantly lower when the organism isolated is multi-drug resistant. Patients infected by multi-drug resistant organisms undergo higher number of surgical procedures compared to patients where the organism is not multi-drug resistant. We conclude that deep infection with MRSA and Methicillin resistant Staphylococcus epidermidis are on the rise. Outcome is significantly better when the organism isolated is non resistant Staphylococcus aureus.


C R Davis J H Newman A P Davies

The purpose of this study was to determine the incidence of revision total knee replacement (TKR) within 5 years of the index procedure at a large multi-surgeon unit using a single prosthesis and to determine the cause of failure of those implants.

This was a retrospective review of all primary Kine-max Plus TKR performed at the Avon Orthopaedic Center between 1.1.1990 and 1.1.2000. Cases were identified that required revision arthroplasty in any form within 5 years of the index procedure. Case notes and Xrays were reviewed to determine causes of failure.

There were 2826 primary Kinemax Plus TKR performed during the study period. Of these 20 were known to have required revision surgery within 5 years. 8 were revised for deep infection of the prosthesis and 12 for aseptic causes. The overall incidence of premature failure of the Kinemax Plus TKR at 5 years was 0.71%. The incidence of aseptic premature failure at 5 years was 0.42%. Detailed examination of the clinical records indicated that some form of technical error at the time of the index arthroplasty was responsible for the early failure of 6 prostheses. This equates to 0.21% of the procedures performed. Aseptic loosening of the remaining 6 cases could not be attributed to a specific cause.


A Carrothers MJ Fehily A Wall A Martin GJ Shepard WG Ryan

Introduction: With the introduction of out-patient waiting time targets, there has been increasing pressure on clinics to accommodate both new referrals and follow-up patients. Departments have found it increasingly difficult to continue long-term follow-up of patients post arthroplasty.

We have piloted a new system of purely therapist led clinics and assessed this with an anonymous patient survey.

Method: Since 2005 and following a training program for the therapists involved, 110 arthroplasty patients have passed through the new clinics. They are seen at 6 weeks, 6 and 12 months and then 3, 5 and 10 years. Their ROM, stability and XRAY findings are documented and each patient completes Oxford Knee, SF 12 and WOMAC scores. If there are problems at any stage they are seen in the surgeon led clinic.

Results: 69% of patients responded to the survey and in general they were very satisfied with the new system. 75% felt that been seen by the therapist alone still fully addressed their needs with 79% having an overall impression of either excellent or very good. The patients rated the therapists professionalism, assessment and information delivery as good to excellent in over 80%.

Conclusion: We feel that with the introduction of this new system, we will be able to continue long-term follow-up of all our patients post arthroplasty. With their regular assessments and scoring we will be able to monitor the success of their replacements and theoretically identify early any problems.


J. Brewin K. Chettiar D Dass P.A. Butler-Manuel

Introduction: Periprosthetic fractures are an infrequent but increasingly prevalent problem and can be technically difficult to manage. Various techniques have been described to manage periprosthetic supracondylar fractures around a Total Knee Replacement (TKR) including, immobilisation, plate fixation, rush rods, LISS (less invasive stabilisation system) and retrograde nailing. The aim of this retrospective study was to evaluate the effectiveness of the retrograde intramedullary nail.

Methods: We identified all patients who underwent retrograde intramedullary nail for the treatment of periprosthetic femoral fractures between January 1999 and October 2005. Notes, x-rays and operation data were examined retrospectively. Outcomes were measured by radiological union, limb alignment, return to function, pain and complications.

Results: Of the 15 patients 2 died of coexisting medical problems during the follow-up period, but both with good fracture alignment. 13 united between 12 – 24 weeks (mean 15 weeks), 11 regained pre-injury function with alignment good in 12. 12 were pain free at follow-up, 2 patients required non-steroidal analgesia intermittently. There was one delayed union (53 weeks). There was one post operative complication where a patient with bilateral fractures required one night stay on ITU.

Conclusion: Intramedullary nailing of periprosthetic fractures around a TKR gave excellent functional results and 100% union in this series.


N Ohly K Rourke P Gaston

Study Purpose: To investigate whether the use of reinfusion drains and post-operative autogenous blood transfusion reduces the rate of allogeneic blood transfusion after primary total knee replacement in our unit.

Methods: A prospective audit was carried out over a 14-week period. Patients received either a reinfusion drain, a suction drain or no drain according to surgeon preference. Post-operative allogeneic blood transfusion criteria were based on clinical indication rather than an absolute haemoglobin level.

Results:127 consecutive patients underwent total knee replacement during the study period. Patients were matched between the three groups for age, medical co-morbidity, DVT prophylaxis, and implant used.

Conclusion: The use of reinfusion drains did not significantly reduce the requirement for post-operative allogeneic blood transfusion. This directly contrasts much of the published literature.


S Joshy A Datta A Perera N Gogi A Modi BK Singh

Aims: To compare the preoperative knee function in patients of Asian origin and Caucasians living in the same community.

Background: The prevalence of osteoarthritis is high in all ethnic and demographic groups. The timing of surgery is important as poor preoperative functional status is related to poor postoperative function.

Methods: Prospective study of 63 Asian patients age and sex matched with Caucasian patients undergoing total knee arthroplasty. Pre operative Knee Society Clinical Rating System scores were recorded as a separate Knee Score and Knee Function.

Results: The mean preoperative Knee Score in Asian patients was 37.6 in comparison to 41.5 in Caucasians (p< 0.10) this difference was not statistically significant. The mean preoperative Knee Function in Asian patients was 32.5 in comparison to 45.0 in Caucasians (p< 0.0001) this difference was highly statistically significant.

Conclusions:Patients of Asian origin undergoing total knee arthroplasty have lower preoperative knee function to Caucasians. Cultural beliefs and social support explain part of this discrepancy but health care providers must also attempt to educate patients and close family members about the importance of timing the surgery to obtain the optimum benefits of pain relief and function.


Y Al-Arabi S D Deo

We devised a four-part clinical risk classification system for patients undergoing primary total knee arthroplasty (PTKR) to facilitate risk estimation. We retrospectively reviewed a series of consecutive PTKRs performed by the senior author. A classification system was devised to take account of principal risk factors in PTKR (Table 1). The patients were grouped accordingly, and the following were compared:

Length of stay

Postoperative complications

Early post discharge follow-up assessment

Multiple regression analysis was performed. This revealed:

Similar complication rates in the NCP and CPI groups.

3-fold and 4-fold increase in the cumulative risk in the CPII, and CPIII groups respectively (p< 0.001)

Increased length of stay in the CPIII group (p< 0.001).

Conclusion: This classification correlates well with complication rates from surgery, and has a role in stratifying patients for preoperative planning and risk counselling. It is reproducible and can be used for larger patient groups via the National Joint Registry. Our findings also have implications for payment by results and fixed tariffs for PTKR.


M Rathinam I Pengas G Stables A Hatcher M McNicholas

Purpose: To subjectively assess and present the outcome after ACL reconstruction with minimum follow-up of 24 months.

Methods: Our knee injury database was established in June 2001. Data were collected prospectively for all knee ligament reconstructions carried out by a single surgeon. The database has a prospectively studied consecutive series where all the patients surveyed completed the Lysholm, KOOS and IKDC 2000 questionnaires preoperatively and at 3, 6, 12 and 24 months postoperatively. Our knee injury database comprises of 163 patients who had ACL reconstruction in which Hamstrings were used in 120 cases and Bone Patella-Tendon Bone (BPTB) grafts in 43. This includes 27 complex reconstructions and 12 revisions (11 from other centres).

Results: Fifty-six of the 79 patients (70.8%) who were at least 2 years post ACL reconstruction attended for their 2 year review. Majority were male patients(90%) and both attendees and non- attendees were of a similar age (30.5 /30 respectively) and did not exhibit a statistically significant difference in their pre op or early post op scores. In the non-attendee group 2 were students, 1 emigrated, 1 registered as unemployed, 7 no employment status and 3 did not consent to such follow-up. The mechanism of injury was, 62 as sporting injury (24 contact/38 non-contact sport), 3 road traffic accidents and 8 activities of daily living and 2 not recorded. The mean scores were, IKDC – 77.14, Lysholm – 83.96 and KOOS symptom – 81.6.

Conclusions: All subjective evaluation questionnaires (KOOS, Lysholm and IKDC) revealed a progressive trend in our patients. We found that in the KOOS, a multidimensional patient completed aggregated score, the Quality of Life (QoL) dimension exhibited results which were interestingly not correlating with the other dimensions of the questionnaire, with patients who scored < 50% occupying manual or non-administrative positions at work


D J Martin S Patil D Byrne W J Leach

Aim: We have carried out a prospective study to compare duplex ultrasonography and transcutaneous oxygen tension as predictors of wound healing after knee arthroplasty.

Methods and Materials: 53 patients were included in the study. All underwent pre-operative duplex scans of their lower limbs. In addition, transcutaneous oxygen tension measurements were made adjacent to the proposed incision pre-operatively and on days 1, 3 and 7 post knee arthroplasty. Wound healing was assessed using the ASEPSIS wound score.

Results: 4 wounds had evidence of delayed wound healing. Duplex ultrasonography was a poor predictor of such problems; however there was a significant correlation between pre-operative transcutaneous oxygen tension and post-operative wound scores.

Conclusion: Pre-operative transcutaneous oxygen tension measurement is a better predictor of wound healing after knee replacement surgery than duplex ultrasonograph, and may be a useful adjunct to the investigation of patients at risk of wound problems post knee arthroplasty.


SG Haidar RM Charity RS Bassi P Nicolai BK Singh

Purpose: The aim of our study was to establish the pattern of knee skin temperature following uncomplicated TKA.

Methods and Materials: It was a prospective study that was carried out between 2001 and 2004. A pocket digital surface thermometer was used. A preliminary study established the site and time of temperature measurement.. Patients with an increased risk of infection and those with a contralateral knee pathology or a previous surgery were excluded. Forty-eight patients fulfilled the inclusion criteria and consented to participate; the skin temperature of operated and contralateral knees was measured preoperatively and daily during the first six weeks postoperatively. Measurements were also taken at 3, 6, 12 and 24 months following surgery. During the course of the study, patients developing complications of the operated knee or any pathology of the contralateral knee were excluded.

Results: Thirty-two patients completed the main study. Following surgery, systemic and both knees temperatures increased. Whereas systemic and contralateral knee temperature settled within one week, the operated knee temperature took a longer time. The difference in temperature between the two knees had a mean value of +2.9oC at 7 days. This mean value decreased to +1.6oC at 6 weeks, +1.3oC at 3 months, +0.9oC at 6 months +0.3°C at 12 months and +0.04°C at 24 months.

Conclusion: Following uncomplicated TKA, the operated knee skin temperature increases compared to the contra-lateral knee. This increase diminishes slowly over several months; however, it remains statistically significant up to 6 months.


G Stables M Rathiman M J McNicholas

Aim: To study the effect intra-operative image guidance has on the position of both femoral and tibial tunnel placement in primary anterior cruciate ligament reconstruction surgery

Methods: Prospective study of 2 consecutive series of 10 patients undergoing ACL reconstruction surgery all operated on by the same surgeon (the senior author). In the first group intra-operative image guidance in the form of a standard image intensifier was used to guide the surgeon in the positioning of the tibial and femoral tunnels. In the second group no image guidance was used. The position of the femoral and tibial tunnels were assessed on AP and lateral radiographs post operatively and recorded. The two groups were compared.

Conclusion: There was no significant difference in the position of the femoral tunnel position between the 2 groups (p=0.23). There was no significant difference in the position of the tibial tunnel between the 2 groups, in either the AP (p=0.37) or lateral (p=> 0.5) plane. There appears to be no benefit to using an image intensifier to aid in tunnel preparation in ACL reconstruction surgery.


N C Carrington V T Veysi S Datir G Pavlou M H Stone

Purpose: We report the 10 to 13 year results of the PFC knee system at our institution.

Method/Results: Between 1992 and 1995 97 PFC primary knee arthroplasties were performed consecutively in 82 patients. 32 patients have subsequently died (37 knees) and four (4 knees) are lost to follow-up. Clinical and radiological review of 46 patients (56 knees) was performed at a mean of 11.1 years post-operatively. Outcome was assessed using the Charnley modification of the Merle D’Aubigne score, with a median of 5 for pain and 4 for function. Radiological failure was defined as progressive radiolucency (1 case), lysis (1 case) or subsidence (1 case). Polyethylene wear was detectable in 10 cases, with > 50% in two. There was 100% survivorship with revision for aseptic loosening as an endpoint. There has been one revision for infection and one patella resurfacing, giving a 98% survivorship with no re-operation. In addition one periprosthetic fracture above a well fixed femoral component, required a supracondylar nail.

Conclusions: The PFC gives excellent outcome and survivorship at 13 years, regardless of the experience of the operating surgeon. This demonstrates that with careful training the PFC is a reliable knee replacement in the long-term for trainers and trainees alike.


S P Badhe M Espag T J Wilton

Purpose of study: To evaluate the ‘Open book’ technique (described below) for the extended approach in Total Knee arthroplasty with respect to its efficacy and outcome.

Summary: Adequete exposure in revision knee arthroplasty can be technically very demanding. Various techniques have been described to aid in exposure. These include Tibial tubercle osteotomy, V–Y quadricepsplasty, rectus snip and Patellar turn-down approach.

Since 1998 the senior author (TJW) occasionally has combined a Tibial crest osteotomy and Rectus Snip-‘Open Book Approach- in revision Knee Arthroplasty where exposure was made difficult by scarring and fibrosis.

The Tibial crest osteotomy is performed as described by Whiteside and this is combined with a 3 cm oblique Rectus snip proximally. This enables the surgeon to reflect the extensor mechanism as if opening a book. This approach protects the patellar blood supply by minimising soft tissue retraction and by making the rectus snip proximal, the feeding vessels in the quadriceps are not distributed.

Methods and Materials: Eight patients requiring Revision Knee arthroplasty in whom the ‘open book’ technique for extended approach to the Knee were reviewed for an average of 4.5 years. The patients were evaluated clinically and radiologically at final follow-up.

Results: All patients made good recovery of range of motion with little evidence of an extensor lag. There was no incidence of refracture, slippage or non-union of the osteotomy.

Conclusions: We concluded that, the ‘Open-Book’ technique is useful in the extended approach of Total Knee arthroplasty resulting in improved clinical outcome with no adverse effects.


H G Said K Baloch M A Green

Revision ACL reconstruction is becoming more frequent especially in specialized centers, due to the large numbers of primary ACL procedures performed.

In two stage revisions, bone grafting of the tunnels may be undertaken if the primary position was inaccurate or if osteolysis has caused widening of the tunnels. This will allow the desired placement of the new tunnels without the risk of loss of structural integrity.

It is technically difficult to deliver and impact bone graft into the femoral tunnel with the standard surgical and arthroscopic instruments.

We describe a new technique for femoral and tibial tunnels impaction grafting in two stage ACL revisions, utilizing the OATS grafting instruments.

The appropriately sized OATS harvester is chosen 1 mm larger than the tunnel size and is used to harvest bone graft from the iliac crest through a percutaneous approach. This provides a cylindrical graft, which is delivered to the femoral tunnel through the arthroscopic portal. The inside punch of the harvester is tapped, this allows delivery of the graft in a controlled manner, and allows impaction into the tunnel. The same is repeated for the tibial tunnel while providing support for the proximal end of the tunnel.


Y Al-Arabi JRD Murray Matthew Wyatt V Satish SD Deo

Aim: To assess the Oxford Knee Score (OKS) for the assessment of soft tissue knee pathology?

Method: In a prospective study, we compared the OKS against the International Knee Documentation Committee (IKDC 2000) and the Lysholm Scores (Lys). We also assessed the OKS with retrograde and antegrade (as currently used in Oxford) numbering. All patients completed 3 questionnaires stating which was the simplest from their perspective. We recruited 73 patients from the orthopaedic and physiotherapy clinics, meeting the following criteria:

Results: Linear regression analysis revealed no significant difference between all 3 scores (R2=0.7823, P< 0.0001). The OKS correlated best with the IKDC (r=0.7483, Fig1), but less so with the Lys (r=0.3278, Fig2). The reversed OKS did not correlate as well (R2= 0.2603) with either the IKDC (r= −0.2978) or the Lys (r= −0.2586). ANOVA showed the OKS to be significantly easier than Lys to complete (p< 0.0001), but not significantly easier than IKDC (p> 0.05).

Conclusion: The OKS is patient friendly and reliable in assessing soft tissue knee injury. This is particularly useful if the OKS is already in use within a department for measurement of severity of degenerative disease.


S R Bollen

Purpose:- to examine changing demographics in ACL Injury

Methods:- the data from a cohort of 117 consecutive patients with ACL injury from a study performed in 1994 was compared with the data from a cohort of 103 consecutive patients with ACL injury collected in 1994/95.

Results:- In 1994, 12% of the patients were female, in 2004 25%.

In 1994, 62% of the injuries were sustained during soccer and rugby, in 2004 58%. In 1994, 9% of injuries were sustained during skiing, in 2004 28% – a 300% increase.

In 1994 the average age was 26.5, in 2004 33. When this increase was examined in detail the average age of the skiers was 41, the soccer players 31 and the rugby players 27.

Clearly there has been a change in the demographics of ACL injury which may have a significant impact in providing NHS services for the ACL injured patient in the UK.


M Rathinam IP Pengas A Hatcher JE Arbuthnot MJ McNicholas

Purpose: To assess the results of ACL reconstructions carried out at our institution in a non-elite cohort of patients with regards to return to active sports post reconstruction.

Materials & Methods: Seventy-five (71%) of 106 patients who underwent reconstruction of isolated ACL tears between June 2001 and August 2004 performed by the senior author completed a newly designed questionnaire (incorporating Cincinnati Sports Activity Scale [CSAS]) to help us fully assess their return to sports and to elucidate reasons if not returning to pre-injury level. 55 were completed at follow up, with objective clinical assessment and other subjective questionnaires [KOOS, IKDC and Lysholm] and 20 were done through telephone interview.

Results: All 75 patients were involved in sports at CSAS Levels 1 & 2 prior to their injury and 39 (52%) had to drop to level 4 after injury. Following reconstruction 61 patients (81.3%) returned to CSAS 1 & 2 levels. 28 of 30 patients (93.3%) operated within 2 years from injury achieved pre-injury CSAS levels compared to 33 of 45 (73.3%) with a longer interval. The mean Lysholm, IKDC and KOOS Sports scores at 12 to 24 months follow up revealed a progressive trend and were 84.9, 76.3 and 73.6 respectively.

One reason for not returning to pre–injury intensity of sports was that many (71.7%) expressed fears of instability though most (70%) had no instability on playing. 77.8% of non-returners who were more than 30 years age reasoned not wanting to risk re-injury compared to 36.8% in the under 30 group. More significantly, 44.4% of over 30s said they were planning to drop their sporting level anyway compared to 5.5% in the younger group.

Conclusion: ACL reconstruction is best done as early as possible after injury for persons intending to return to competitive sports. The results are even better after early intervention in younger patients. Psychosocial issues play a significant role in return to active sports.


N Davidson M Rathinam IP Pengas A Hatcher MJ McNicholas

Introduction: This prospective study is designed to evaluate PCL reconstruction using the arthroscopic ‘double bundle technique’ in a consecutive series of patients with multiple ligament instability.

Methods: 12 consecutive patients who underwent arthroscopic posterior cruciate ligament reconstruction at Warrington Hospital for a combined ligament injury with PCL tear between 2001 and 2004 were included in the study. The indication for surgery was functional disability of the knee due to pain and instability. All were male patients with an average age 33 years (range 18 to 44). Average time from injury to surgery was 31.5 months (range 1 day to 96 months). The evaluation parameters included functional assessment, clinical examination, and functional score. All data was collected prospectively. The average period of follow up was 23months (range 9 to 50 months)

Results: Using the IKDC subjective assessment 63% of the patients had normal/near normal knee function (range 16 to 94). On Lysholm scoring 71% reported good or excellent results. On objective examination 83% had abolition of reverse pivot with 91% showing no evidence of PLC instability.

Conclusions: Arthroscopic double bundle PCL reconstruction in this study produced a satisfactory clinical outcome in terms of return to function objective assessment and symptom improvement. The technique has improved results in terms of outcome than previous reports in the literature would suggest.


D Adams D Houlihan-Burne J Webb

Statement : A prospective review of the clinical outcome following reconstruction of isolated posterolateral corner (PLC) injuries to the knee.

Method : 10 patients underwent an isolated PLC reconstruction for symptomatic instability. All patients had preoperative and post operative clinical examination, and functional knee scores.

Results : There were 9 males and 1 female, mean age of 35, with 100% follow up. Median length of follow up was 46 months (range 2 – 69). At the latest follow up, the mean Lysholm scores were 89.9, with an average increase in Tegner scores of 3.3 (range 2–10). IKDC scores showed a median of 93 (66 – 100). All patients had < 3 mm mean side to side difference using the KT1000 arthrometer, and no increase in PLRI. There were no complications and no clinical failures requiring further surgery. All the patients said they would undergo the surgery again.

Conclusion : In this series of patients with symptomatic PLC injury, hamstring graft reconstruction has restored knee stability with good functional outcomes.


A Bhatti M Shah J N Brown

Introduction: To report the results of quadrupled hamstring tendon autograft anterior cruciate ligament reconstruction with bioabsorbable Rigidfix fixation for both femoral and tibial tunnels.

Methods: ninety one patients were retrospectively identified by notes review as having undergone quadrupled hamstring tendon auto graft anterior cruciate ligament reconstruction with Bioabsorbable Rigidfix fixation with a minimum 1 year follow-up[range12 to 34 months] To our knowledge there has been no published results with Rigidfix device used as a method of fixation at both femoral and tibial tunnels

Results: Data were collected on 91 knees in 91 patients (100 %) at an average 13 months (range, 12 to 34) after surgery. They were all asked to fill in a subjective quetionaire. Seventy eight patients returned for clinical evaluation (85.7 % return) and subjective questionnaire was comleted by 78 patients (85.7 %).

The KT-2000 Arthrometer, mean side-to-side difference for manual maximum displacement was 1 mm (range, 0 to 3). Anterior compliance index mean side-to-side difference was1 (range −1 to 3), Quadriceps active displacement tests mean side-to-side difference was.5 [range −1 to 2]. The mean International Knee Documentation Committee knee score was 89 (range, 33.3 to 100).

Conclusions: Quadrupled hamstring tendon auto graft anterior cruciate ligament reconstruction with Bioabsorbable Rigidfix fixation is comparable with other methods of anterior cruciate ligament reconstruction in terms of patient satisfaction, knee stability, and function.


A Yousef E. Hargin R Hill D Wilson DA Walsh

Aim: The Système Française D’Arthroscopie (SFA) is a validated method of arthroscopic grading and scoring the knee OA. We have validated a modification of the SFA system for use with digital photographs of pathological samples.

Material and Method: After Ethics Committee approval, both tibial plateaux and femoral condyles were collected from 84 patients undergoing total knee replacement or at post mortem. Extent and grading of cartilage changes were documented for the 4 compartments of each sample on a diagram using photographs at standard magnification and illumination, archived, (Photographic Scores). Validation obtained by direct visualisation and probing (Pathological Scores). Radiographic and Histological scoring In addition, each sample was digitally. A second observer (AY) also graded and scored photographic images for 72 compartments of the first 18 cases.

Results: For each of the 4 compartments studied, scores ranged from -2.2 to +717.8, representing the full range of possible scores. A statistically significant correlation observed in the study between radiological variables and the severity of chondropathy assessed by our (SFA-path) [ P < 0.005] suggests satisfactory extrinsic validity of this scoring system. And statistically significant correlation [p> 0.0001] between the SFA Path scores of the medial compartment tibial plateau OA and Histologi-cal grade [Minkin] of the same samples. Allocation of scores to diagrams was highly repeatable (Repeatability Coefficient = 50). There was good agreement between Pathological and Photographic Scores (Repeatability Coefficient = 88). There was moderate agreement between Photographic Scores allocated by the 2 observers, with greatest agreement for low (< 200) and high (> 500) scores. Scores for each compartment correlated with scores for each of the other 3 compartments (R values 0.7 to 0.9, all P < 0.005).

Conclusion: We validated our modified SFA system which permits scoring of OA severity using digital photographs of pathological samples. SFApath is reliable and repeatable scoring system Our data support the view that OA affects the entire joint, and that a single compartment (e.g. medial tibial plateau) can be taken as broadly representative of the tibiofemoral joint as a whole.


S Joshy B Thomas N Gogi A Modi B K Singh

Infection following total knee arthroplasty is a serious complication. Recently there has been increasing incidence of isolation of multi-drug resistant bacteria from peri-prosthetic infections. The aim of our study is to identify the organisms causing delayed deep infections following primary total knee arthroplasty in the current situation. We also compared the differences in outcome based on the infecting organism. We undertook a retrospective study of all the patients who presented with delayed deep infection following primary total knee replacement during a six year period between April 1998 and March 2004. Organisms were isolated in 27 of the 31 patients who presented with delayed deep infection. Forty-four % of the organisms isolated were multi-drug resistant with increasing incidence of Methicillin resistant Staphylococcus aureus and multi-drug resistant Staphylococcus epidermidis infections. Successful outcome following an infected total knee arthroplasty was lower compared to the previous studies where there were fewer multi-drug resistant organisms. The average number of surgical procedures carried out was significantly higher when the organism isolated was multi-drug resistant. The number of patients with satisfactory outcome is significantly lower when the organism isolated is multi-drug resistant.


M Bhattacharyya B Gerber

Background: We aim to compare our final results of Autologous Chondrocyte Implantation in full thickness articular cartilage defects of the knee with the outcome as reported in the literature.

Material: 9 patients median age of 29 (range 24 to 42) were operated and assessed clinically with use of International Cartilage Repair Scoring (ICRS), VAS and oxford knee score pre operation and 3, 6, 12 months post operation. 66.6% of the patients had traumatic defect due to sport injury and was located on the medial femoral condyle.

Method: Arthroscopically slivers of cartilage (300 to 500 mg) were obtained from the upper minor load-bearing area of the medial femoral condyle of the injured knee for cell culture. Implantation was performed by open procedure following periosteal cover technique and use of fibrin glue as a bioscaffold 4 weeks after the biopsy.

All the patients started knee exercise with CPM from next day and allowed to bear partial weight on the operated knee for 8 weeks.

Result: 3 patients still had pain after one year follow-up. One case had mosaicoplasty after 8 months, which we consider as a failure and two of them had second Arthroscopy, trimming of part of repaired cartilage. 67.2% of the patients had a good or excellent result.

Conclusion: All patients showed improvement of clinical symptoms except one patient who failed at 8 months. We found our results are comparable as reported in the literature in this small cohort. This kind of surgery may be performed in a non referral hospital.


M Hossain A Hussain

Arthroscopic surgery is a common intervention for osteoarthritis of the knee. However, the benefits from such an intervention are not clear. The purpose of the study was to perform a questionnaire survey of orthopaedic surgeons of Wales to analyse the practice of arthroscopy for osteoarthritic knee.

Over a three-month period, a postal survey was conducted of all hospital orthopaedic consultants in Wales. Of a total of 62 questions sent we received a reply of 37. 31 surgeons perform arthroscopic lavage or debride-ment. 4 surgeons perform arthroscopic surgery for symptomatic meniscal tear only. There was no defined protocol regarding the management. Early OA was the commonest indication (18). Arthroscopic lavage (17) was equally popular to lavage and debridement (16). 6 respondents like to perform the surgery themselves while the majority would allow a middle grade surgeon to operate with or without supervision. 26 surgeons felt that the results of the procedure are unpredictable, but still continued to perform it. Only 6 surgeons felt a continued relevance of the procedure.

Arthroscopic surgery is a commonly performed symptomatic treatment for arthritic knee. It bears a significant financial commitment. 266 arthroscopic knee surgery were performed annually in a district general hospital, of whom 115 were arthroscopic washout. Average cost of each operation is £1000. The physiological basis for arthroscopic washout is not clear. A majority of the Welsh surgeons have reservations about this procedure. In spite of evidence of limited usefulness, it is still performed widely.


S Dhotare M Saif S Kamineni F Wadia

Aims: Intra-bursal versus inter-scalene post-operative effective pain control for Arthroscopic Shoulder Surgery

Methods: We prospectively collected data over a consecutive two year period, the first year patients (n=65) all having inter-scalene and the second year patients (n=79) having intra-bursal catheters. The interscalene 16F catheters were placed with the patient anaesthetised and an electrical Touhy needle. The intra-bursal 16F catheters were placed at the end of the arthroscopic shoulder operation, under direct vision, exiting from the posterior portal. Pain parameters collected were pain scores, visual analogue scales, analgesia usage, and whether or not the patients were comfortably able to go home the same day as surgery.

Results: Pain and visual analogue scores showed no statistical differences between the two groups. Analgesia usage was greater in the inter-scalene group than the intra-bursal group, but was not statistically different. 32/65 (49%) of patients with inter-scalene catheters and 75/79 (95%) of patients with intra-bursal catheters were able to comfortably go home on the day of surgery, 28/33 (84%) of the inter-scalene patients were hospitalised due to post-operative pain, and 5/33 (15%) due to anaesthetic or medical problems. 2/4 (50%) of hospitalised intra-bursal patients had post-anaesthetic complications, and 2/4(50%) had pre-operative medical problems.

Conclusions: Inter-scalene analgesia is widely published as the most effective for post-shoulder surgery pain control. Our data does not support this view, intra-bursal analgesia administration was found to be more effective at returning a comfortable patient home on the day of surgery. Our practice now routinely utilises intra-bursal catheters for either bolus analgesia or continuous pumps.


Erman Y Melikyan M S A Beg Mary J Bradley Frank D Burke

AIM: The aim of this study is to assess the efficacy of different treatment options for wrist ganglia.

METHODS AND RESULTS: 1700 cases were reviewed retrospectively. Of the respondents to the questionnaire, 457 (65%) patients had dorsal, 255 patients (35%) volar wrist ganglia.

Dorsal ganglia had been treated by observation in 99 (22.4%), aspiration in 57 (12.9%), aspiration plus injection in 37 (8.4%) or surgery in 249 (56.3%) of the cases. The analysis showed that the recurrence rates were 39%, 74.5%, 28.5%, and 35% respectively for each type of treatment. Scar tenderness was present in more than half of surgically treated patients. Repeat surgery was performed in 20 out of 70 (28.5%) recurrent cases. The satisfaction rate did not correlate with the recurrence rate.

For volar ganglia, treatment had been observation in 49 (19.2%), aspiration in 13 (5%), aspiration plus injection in 12 (4.7%) or surgery in 153 (60%) of the cases. The analysis showed that the recurrence rates were 28.5%, 92%, 25.5%, and 33.3% respectively. Scar tenderness was present in 67% and sensory loss in 32% of surgically treated patients. Repeat surgery was only performed in 18 out of 52 (34.6%) recurrences. The satisfaction rate was highest in the aspiration and injection group, which had the lowest recurrence rate among all treatment modalities.

CONCLUSION: The treatment of wrist ganglia needs a rethink in the light of the current findings as the complications may be difficult to justify in such a self-limiting condition.


Hazem Hassouna Dishan Singh Heath Taylor Steve Johnson

Objective of the Study: To assess the clinical effectiveness of ultrasound guided injection in the management of Morton’s Metatarsalgia.

Patients and Methods: Patients, that were clinically diagnosed to with interdigital Morton’s neuroma were treated with ultrasound guided injection of local anaesthetic and steroid. Fifty three patients were available for follow-up, and all had detailed telephone questionnaires completed. These questionnaires included a pre and post injection symptom score, as well as a Johnson Satisfaction score.

Results: 69% of patients had ultrasound diagnosis of Morton’s neuroma and 31% had an ultrasound diagnosis of intermetatarsal bursa. Mean follow up was11.4 months (Range: 3-23 months).67% of the patients were satisfied with the results of treatment. At follow up 63% of patients had no limitation in activity levels, and had no need to modify their shoe wear. Of all patients included in the study, only 3 patients have gone on to require surgery for ongoing symptoms.

Conclusion: Some studies have suggested that neither injection nor imaging have a role in the treatment of Morton’s neuroma. This study, however, demonstrate that ultrasound guided placement of local anaesthetic and steroid in either an intermetatarsal bursa or Mor-ton’s neuroma gives a good short and medium term symptom relief and in the majority of cases avoids the need for surgery.


S Ansara S Masud AE Moftah S El-Kawy SS Geeranavar

To compare outcome between the medial and posterior approaches for the surgical treatment of supracondy-lar fractures when performed by two experienced surgeons.

A retrospective analysis of 45 children, mean age of 5.5 years (2.5-11 years), treated for closed Wilkins IIB/III supracondylar fractures without vascular deficit between January 1999 and December 2004. Twenty-one and twenty-four children were treated using the medial and posterior approaches respectively. The medial approach is quicker but technically demanding. The posterior approach is easier but cuts through the intact posterior structures. In both groups the fracture was stabilised using crossed K-wires and the arm was immobilised in an above elbow backslab for 3 to 4 weeks. Follow-up was at 3 to 4 weeks, 3, 6, and 9 months, and at 1 year. The results were assessed clinically using Flynn’s classification and radiologically using the metaphyseal-diaphyseal and humerocapitellar angles.

There was no post-operative infection or redisplace-ment. Clinically, the medial approach gave 18 excellent, 2 good, and one fair result, and the posterior approach gave 21 excellent, 2 good, and one fair result (P> 0.50). Radiologically, the medial approach gave 18 excellent and 3 good results, and the posterior approach gave 20 excellent and 4 good results (P> 0.50).

We found no significant difference in outcome between the two approaches, both giving mostly excellent long term results. Each approach has its known merits and drawbacks. This type of fracture needs an experienced surgeon comfortable with his preferred approach.


Hazem Z Hassouna Stephen P Bendall

Objective: The purpose of this study is to evaluate the prognosis of arthroscopic ankle treatment. Also we will formalise the relationship between the arthroscopic treatment and time for a further major ankle surgery

Patients and Methods: Consecutive Case Series study using prospectively gathered database. Between January 1997 to December 2000, Eighty consecutive patients (80 ankles) having ankle arthroscopy with the finding of Osteoarthritis (OA) or impingement were identified and their outcome at five years ascertained.

Arthroscopic procedure involved pre operative skin markings. Ankle distraction is used. An anterior approach used with standard Anteromedial and antero-lateral portals.

Treatment: debridement of osteochondral lesions, removal of loose bodies, curettage, drilling, synovec-tomy, and abrasion of the subchondral bone. All ankle joints had wash out.

Results: Results were examined using Kaplan Meier survival analysis. Statistical analysis of the results was done using Chi squared test.

Fifty five (69%) patients had soft tissue impingement, and 25 (31%) patients had osteoarthritic degenerative changes.

Seven (9%) patients had further major surgery and 6 (8%) had repeat arthroscopy.

The surgery was required for 7 arthritic ankles (7/25).

Survivorship: Survival analysis

28% of osteoarthritic patients progress to major ankle surgery, within 5 years of arthroscopic treatment. None of patients with impingement symptoms required further major surgery.

No statistical significance between those under 50 and those over 50 years in OA group

Conclusion: Arthroscopically treated impingement Ankles has an excellent prognosis, while osteoarthritic ankles have less favoured prognosis, with high proportion requiring further major surgery. Age does not affect prognosis in O.A group. Arthroscopy for OA, is likely to fail within 18 months.


A S Desai S S Mysore A K Choudhary

Aim of the study: to assess the early complication rate following k-wiring of distal radius fractures and their clinical outcome. A retrospective treatment.

METHOD: 48 patients with 50 Distal Radial fractures, number? High velocity (26 Males, 22 Females; Mean age 34 years; Range 4 to 88 years) treated by Closed K-Wiring during the period between January 2005 to June 2005 were assessed in terms of early complications following MUA and K-Wiring and their final outcome. All cases were performed by staff grade or above.

12 patients (24%) had discharge, pin tract granulation, loosening, out of which 4 required antibiotic. Out of 12 only 2 (4%) has positive swab culture requiring Intravenous antibiotics.

3 patients (6%) had symptoms suggesting superficial radial nerve damage of which 2 recovered completely after pin removal. One had residual symptom, put on waiting list but symptoms got better and she refused further treatment.

9 patients (18%) had stiffness out of which only 3 (6%) had residual stiffness at the end of 6 months. However this stiffness can not be attributable to k-wiring alone (?fracture intra articular).

CRPS was noted in 1 patient (2%) and recovered after prompt physiotherapy. There were no cases of deep infection, osteomyelitis, tendon rupture, pin migration or significant loss of position in our study.

CONCLUSION: Our data suggests that though early complication rate of K-wiring is alarming, it does not affect the final outcome of fracture management; and this complication can be avoided by proper technique and care.


V Kumar A Hameed R Bhattacharya F Attar I McMurtry

Aim: 1. To assess the role of the CT scan in management of intra-articular fractures of the calcaneum. 2. Does the scan makes any difference to the management decision, obtained from assessing the plain radiograph?.

Methodology: This study involved 24 patients with intra-articular fracture of the calcaneum who had both a plain radiograph and a CT scan as a part of their assessment. Three consultants who were blinded to the actual management and names of the subjects were independently asked to grade the radiographs and CT scans, as operative or non-operative, on different occasions. The data was matched to the actual management and was subjected to statistical analysis.

Results: The data was non-parametric and related. The SIGN test was used to analyse the agreement between the three observers and if the decisions made in each of the groups were significantly different from the actual management. There was no statistically significant difference, between the management decision from the radiographs or CT and the actual management.

The change in management that the CT scan brought about was also assessed for each of the observers using the McNemars test. The CT scan did not make any significant difference to the decision made based on the plain radiographs, on whether to operate or not.

A Cochran Q test used to assess the variability of the decisions, showed that there was more inter-observer variability in decision making, using the CT based assessment (Q=9.50, p=0.009) as compared to plain radiographs (Q=3.84, p=0.14).

Conclusion: We conclude that, the CT scan should only be requested when a decision is made to operate on the fracture, based on plain radiographs. This may help with pre-operative planning of fracture fixation. It does not have to be obtained as a routine to assess all intra-articular fractures of the calcaneum.


JTK Melton J J Reynolds SD Deo

Background: We have devised a modified Pivot Shift test with which to assess ACL deficiency which does not require forced tibio-femoral subluxation. The test is scored on patient reaction to the initiation of the pivot shift without actually having to elicit that ‘shift’ which can be painful. We call the test the Pivot Apprehension test.

Methods: We retrospectively analysed a cohort of 81 patients who were potentially ACL deficient and sought orthopaedic intervention over a period of 3 years and correlate their initial ‘pivot apprehension’ score with the degree of ACL deficiency found at subsequent arthros-copy and/or MRI.

Results: Using contingency tables and Fishers Exact test we calculate that the test has a positive predictive value (for predicting ACL Rupture) of 94% (p=0.026) and a sensitivity of 89% (Specificity 60%). Linear Regression analysis shows a correlation coefficient (r) of 0.47 (p=0.0008).

Conclusion: The data we have collected in this study show that the ‘Pivot Apprehension Score’ is a clinical tool with a high positive predictive value for ACL injury which provides the same information as the Pivot shift test without having to cause painful tibio-femoral sub-luxation thus obviating the clinical need to elicit ‘pivot shift’ in the conscious patient.


S Singh K Vishwanathan MP Patel RN Daveshwar

Purpose of study: We aimed to compare the efficacy and effect of Ender nail and unreamed interlock nail in the management of Type I, II and IIIA fractures.

Methods: 33 cases of open tibial shaft fractures in 32 patients were included in this prospective study. 17 tibial fractures were fixed with Ender nails introduced by antegrade approach and 16 tibial fractures were fixed with statically locked Interlocking nails. The mean follow-up period was 17.8 (6 to 32) months. The mean injury-surgery interval was 5.6 (1 to 16) days.

Results: In the Ender nail group, the average union time for open fracture was 19.5 weeks and 18.3 weeks for Type-I fracture. In the Interlock nail group, the average union time for open fracture was 24.8 weeks and 23.8 weeks for Type-I fracture. Mann-Whitney test revealed significant difference between the two groups for the data described above. Treatment with either nails showed no significant difference in union time for Type-II and type-IIIA fractures. Ankle movement restriction was noted more in interlock nail group (p = 0.04). Anterior knee pain, chronic osteomyelitis and breakage of distal screw were observed in interlock nail group. No complication was seen in Ender nail group.

Conclusion: Ender nailing is a safe and effective choice for treatment of open tibial shaft fractures due to faster fracture union rate and fewer complications. Ender nail is a good implant in treatment of open tibial shaft fractures especially in regions with limited access to specialized, sophisticated and expensive facilities.


U Rethnam A Shoaib R Bansal A De

Background: The Mini C-arm has been heralded as a safer means of fluoroscopy. No clinical data on the use of mini C-arm is available in the literature.

Aim: The purpose of this study was to compare the exposure in clinical practice from the conventional C-arm and the Mini C-arm and scrutinize patterns of exposure.

Materials/methods: Case-Control design. All operations using the mini C-arm were reviewed. Control cases were identical operations using the conventional C-arm. The Sign test was used to detect the number of exposures taken and the dose of radiation.

Results: There were 16 operations with valid case-control pairs. The number of exposures performed was significantly greater for the mini C-arm (p=0.05), but the emitted dose of radiation was significantly smaller (p< 0.001) for the mini C-arm.

Conclusions: The mini C-arm is a safer device for extremity surgery, but the surgeon should be careful to avoid excessive exposures.


P Shah

The purpose of this study was to evaluate the outcome of internal fixation for undisplaced intracapsular fracture neck of femur in elderly group of patients with a view to evaluate the incidence of definitive procedure at a later date.

The method used for evaluation was retrospective study of 46 consecutive cases within one year, operated for Garden 1 or 2 type of fractures, who were followed up for upto 2 years. Postoperative complications, the need for further intervention and relationship with age and preoperative ASA grade was assessed.

Results of the study were quite interesting. 74% patients were above the age of 60 years. 60% of them (30 out of total 46) stayed in the wards for more then one week, due to medical problems. 35% (16 out of total 46) required further intervention in form of hemi-arthroplasty or total joint replacement, either due to implant failure or avascular necrosis. 63% of those who required further intervention 10 out of 16) were ASA grade 3 or above.

Conclusion of the study was that although internal fixation is a relatively small procedure, the complication rate, requiring further intervention was higher then anticipated. There is a role of primary definitive procedure in certain number of cases, specially those having higher anaesthetic risk i.e. ASA grade 3 or above.


G K Singh R G Deshmukh L J Taylor M C Moss

Periprosthetic fracture of the femur after hip arthroplasty is a difficult problem. Management depends on different clinical factors and these are fractures are managed at District General Hospitals.

Present series is of fifty such fractures presenting between 1999 and 2004 in two District General Hospitals in England. Number of female patients were more than males and majority of patients sustained these injuries after trivial fall.

Outcome of management are analysed according to modified ‘Tower and Beals’ criteria (1999).

Eleven patients lost to follow-up, twelve patients died (mortality was twenty-four percent) during follow-up. Twenty-one patients progressed to clinical and radiological union at an average of eight and eleven months respectively. Six patients are under follow-up.

Although several results are published in literature but the present result is comparable to the most literatures. If certain principles are followed comparable results can be obtained in District General Hospitals by Surgeons with a special interest in the management of these fractures.


K Rajaseker A A Faraj

Aim: To study the influence of cement restrictors on the thickness and quality of femoral cement mantle.

Methods: In this prospective study, there are 49 cases of Hardinge restrictor and 33 cases bone block restrictor were used for Charnley hip replacement. The operation was carried out by one surgeon on 78 patients between 1 March 2003 and 30th April 2004. Each preoperative X-rays were templated for the placement of restrictor. Intraoperatively, a calibrated holder for the cement restrictor was used aiming at keeping the distal cement height within 2-3 cm of the tip of the femoral prosthesis. Postoperative X-rays were checked for cement mantle thickness and quality.

Results: The preoperative target of having a distal cement height of 2-3 cm was achieved as seen on postoperative X-ray in only 60.6% of the bone block group and 30.6% of the Hardinge group. Distal migration of the restrictors was associated with non-homogenous cement mantle in zones 3, 4 and 5 but did nor affect zone 2, 6, or7. As the restrictor remained within 20-30 mm, the thickness of mantle is maintained between 9mm and 21mm in zone 4. This finding is statistically significant with the p value of 0.001.

Conclusion: Though the bone block was marginally better than Hardinge restrictor, we conclude that the current available cement restrictors are not sufficiently good enough to offer a good cavity for cement intrusion in to the bone; further restrictors need to be developed and tested before clinical use.


A S Rajeev S Thomas J Pooley

Purpose: The aim our study was to establish the existence of a symptomatic humero-radial synovial plica causing lateral elbow pain and the resection of which has improved pain and restored elbow function

Materials & Methods: Our study included 117 consecutive elbow arthroscopies performed by two surgeons for a period of 18 months from January 2002 to July 2003.

All patients were treated non operatively before undergoing arthroscopy. Conservative treatment included rest, activity modification, physiotherapy including ultrasound bracing, NSAIDS and corticoste-riod injection.

Results: Radial head plica were found in 21(18%) out of 117 elbow arthroscopies and were resected using a soft tissue resector. There were 16 men and 5 women in the study group,all of whom were young and active: mean age 38 years (range 24 to 56 years). All patients were scored pre op and post op using the Mayo clinic performance index for the elbow. Of the 21 patients 17(81%) had a post op score 90 or more(excellent) and 5(19%) had a score 75-89(good)

Conclusion: The synovial fold of the humero-radial joint is documented and considered as a meniscus between the two articulation(Duparc f etal 2002). They can also present present as symptoms suggesting intra articular loose bodies(Clarke R.P etal 1998).

In the case of resistant tennis elbow the existence of a radial head synovial plica should be considered. Our study concludes that by resecting the synovial plical fold will relieve the pain and restore the elbow motion.


O. Ekeocha M. Bhattacharyya

Background: To highlight the higher incidence of sub-trochanteric fracture following cannulated screws fixation for the neck of femur fracture, which may be due to surgical errors and osteoporotic bone

Method: Illustrative case report of a 78 years old demented independently mobile female patient who was admitted with an intracapsular Neck of Femur fracture, treated with cannulated screws. 2 weeks post operatively, she developed subtrochanteric undisplaced proximal femoral fracture without any trauma. She was treated with cemented hemiarthroplasty.

Conclusion: The valgus impacted neck of femur fracture, treated with cannulated screws is associated with some inherent problems. The cannulated screws can become incarcerated during initial open-reduction internal fixation and break. The incidence of subtrochanteric fracture following hip operation is greater with an entry point in the lateral cortex below the level of the most inferior edge of the lesser trochanter. Although in our case study, we placed the screw above the lesser trochanter. It has been reported that two screws in the inferior part of the femoral neck create a stress riser in the sub-trochanteric region, potentially inducing a fracture in the weakened bone, and it may be induced by a trauma. In this case study failure may be due to multiple drill holes on the lateral cortex during insertion of the guide wire [fig 2].

Subtrochanteric fracture following cannulated screws may occur without trauma. Osteoporosis may have a major role to play. We recommend one screw infe-riorioly and entry point above the lesser trochanter as reported previously.


K Vishwanathan N Modi KJ Patel RN Daveshwar PP Golwala

PURPOSE OF STUDY: We report our experience with multiple flexible intramedullary nailing (Ender nailing) of fractures of shaft of the femur in paediatric age group.

METHODS: We did a prospective review of 20 children (mean age- 8.8 years; range- 6.5 to 15 years) treated with Ender nailing. Fall from height was the predominant mechanism of injury (18 children). The mean follow-up period was 16.3 months (range- 4 to 28 months).

RESULTS: 18 fractures united by 6-8 weeks and 2 fractures united by 8-10 weeks. Minor limb length discrepancies were seen in this series (range, -5mm to +10mm). 2 children had shortening of 5mm while 4 children with upper third fractures had 10mm lengthening. All patients were able to squat on floor and sit cross-legged. All but one patient had full hip and knee range of motion. Varus angulation of 15 degree was seen in 2 patients who were non-compliant and had started early weight bearing. Backing out of 1 nail was seen in 1 patient and the nail was extracted. TEN outcome scoring system was used to critically analyse the results. 16 children had excellent outcome, 2 children had satisfactory outcome and 2 children (with varus malunion) had poor outcome.

CONCLUSION: Ender nailing is a safe and effective method for treatment of femoral shaft fractures in children between the age of 6 and 15 years. Patient compliance is crucial for a satisfactory outcome since early full weight bearing can predispose to varus malunion.


A Yousef R K Pagoti R K Morisetty P Bolton

Aims: Hypokalemia is a common electrolyte imbalance with signficent effects. The aim of our study is to identify incidence, causes and prognostic implications of postoperative hypokalemia in elderly patients operated for fracture neck of femur.

Methods and material: Retrospective study, of 404 consecutive fracture neck of femur patients who were operated in our hospital between October 2001 and July 2003. Patients identified with postoperative hypo-kalemia the medical notes, fluid charts and anaesthetic notes were analysed for age, preoperative morbidities, medications, mechanism and type of injury, waiting time for operation, pre, peri and postoperative fluid management, type of anaesthesia, operative time, hospital stay and mortality.

Results: Out of the 404 patients, 54(13.3%) were hypokalemic (K< 3.5mmol/l) postoperatively. Of the 54 patients 16 (29.6%)had preoperative hypokalemia.

Among the hypokalemic group the mean preopera-tive potassium was 3.69mmol/l and the mean postoperative potassium was 3.19mmol/l. The t-test showed a statistically significant difference between mean pre and postoperative potassium levels. (P< 0.0001). High association was found with hypokalemia and post-operative dextrose infusion (38%). 50% of patients on diuretics developed hypokalemia post operatively. Interestingly, only 18% of these were hypokalemic pre operatively.

In patients with multiple medical problems, like diabetes, hypertension and CVA, high incidence of hypokalemia was found. (38% had 2 or more medical problems).

No significance in the mortality rate was found in fracture neck of femur patients with and without postoperative hypokalemia (40% vs. 39% at 3yrs).

Conclusion: There is significant risk of hypokalemia following orthopaedic surgery, especially in the elderly. This avoidable condition, which has serious consequences, should be dealt with care in the orthopaedic units. Fluid infusion regimes and should be formulated and medications reviewed to prevent conditions like hypokalemia.


A Arya G Kakarala R Kulshreshtha G Groom J Sinha

Proximal humeral fractures are common injuries but there is no general agreement on the best method for fixing unstable and displaced 3 & 4 part fractures. A new implant – Proximal Humeral Internal Locking System (PHILOS) – has recently been introduced to fix these fractures. The aim of this study was to assess the effectiveness of the PHILOS plate in the surgical treatment of these fractures.

We operated upon 36 patients between March 2002 and December 2004. 33 of them were available for follow up, which ranged from 12–45 months. Assessment at follow up included radiological review, Constant and DASH scoring.

While recovery of movements and relief in pain was satisfactory, the strength of shoulder did not recover fully in any patient. There were two failures in our series, one due to breakage of plate. 4 patients have shown radiological signs of avascular necrosis of humeral head. The plate was removed in 4 patients due to impingement and / or mechanical block in abduction. Another 2 patients had to undergo arthroscopic subacromial decompression for the same reasons. We encountered the problem of cold welding and distortion of screw heads, while removing the PHILOS plate.

The broken plate was subjected to biomechanical and metallurgical analysis, which revealed that the plate is inherently weak at the site of failure.

The PHILOS plate does have inherent advantages over other implants for fixation of 3 and 4 part proximal humeral fractures but we are not convinced about its strength. Design of its proximal screws also appears less than satisfactory. The plate may cause impingement in some patients necessitating its removal later on, which itself may not be easy.


A Ahmed

Introduction: Ankle fractures are one of the most common injuries treated by the orthopaedic surgeon. The general recommendation is if surgical treatment is not carried out within the first 24 hours from the injury, then it should be delayed for about 5-7 days to reduce the risk of wound complications associated with limb swelling. The aim of our study was to see whether timing of surgery significantly affects the outcome or wound complications following internal fixation of displaced ankle fractures.

METHOD: We retrospectively analysed the medical records of 37 patients with ankle fractures, who were admitted to the orthopaedic department at our Hospital between May 2003 and May 2004. The fractures were classified according to Dennis-Weber classification. Open reduction and rigid internal fixation was performed according to the techniques of the Association for the Study of Internal Fixation (AO Group).

RESULTS: The mean age of the patients was 41.6 years (range 19-70). According to Denis-Weber classification 2 (6%) were type A, 26 (70%) were type B and 9 (24%) were type C fractures. The mean delay before surgery was 2.4 (0-9) days. The mean length of hospital stay was 4.6 (1-13) days. 35% of the fractures were operated between the second and fourth days after the injury without any increase in wound or fracture related complications. There were no cases of wound infection or dehiscence. Although there was one case of delayed union of medial malleolus, the overall union rate was 100%.

CONCLUSION: We conclude that for ankle fractures that are not operated on within the initial 24 hours from the injury, delayed treatment could be instituted as soon as patient and limb factors permit and rigid adherence to waiting times of 5-8 days is not necessary.


G Abbas S L Bali A Waheed D J N Dalton

Bone grafting is used extensively in orthopaedic reconstructive surgery. Revision hip arthroplasty often presents surgeons with difficult bone loss problems, which can sometimes be addressed using donated bone. This need for bone graft has increased in recent years with greater numbers of joint replacements and increasing life expectancy after replacement, particularly as prostheses are being implanted into younger patients. Current practice of bone banking involves careful donor selection, stringent screening tests and internal safety systems in bone banks to prevent the ever present threat of communicable diseases. Introduction of strict monitoring systems to prevent allograft-related diseases has rendered a significant number of primary hip replacement patients unsuitable for bone donation. This study audited the practice of bone banking at Portsmouth Hospitals NHS Trust to look into various factors responsible for exclusion of patients from bone banking. All 55 patients underwent screening in pre-operative assessment clinics using standard Proforma to assess their suitability for femoral head donation during the course of their primary hip replacement surgery. After the initial screening stage 33 patients (60%) were excluded due to variety of reasons. The majority of those excluded (23 patients) were not accepted as donors because of their potential risk of transmission of disease to the recipients. The situation is likely to become worse in future as the incidence of communicable diseases is rising in the UK. Alternative sources of bone grafts should be explored in future to meet the demands for, example auto-banking.


K J Barlas T K Bagga F R Howell J A Roberts

The purpose of this study was to review the midterm results of HAC coated bipolar hemiarthroplasty in patients with displaced intracapsular fracture neck of femur in elderly patients.

There were 264 patients with 274 fractures from November, 2001, to June, 2004. The operations were performed by employing a similar technique and anterolateral approach. Postoperative treatment was same. The mobility was assessed by ambulation. Pain was evaluated using a visual analogue scale and clinical evaluations were performed using the Harris Hip Scoring System.

The mean age of 142 survived patients reviewed in the study was 77.5 years (range 61-89 years) at the time of operation and mean follow-up was 25 months (range 18-48 months). Hundred and twenty six patients had no or mild occasional pain but no restriction of activity. Ninety of the ninety eight able to walk independently or with one stick before fracture were doing the same. The surviving implants were radiographically stable and demonstrated evidence of osseointegration and no acetabular wear. Harris hip score averaged 84 points. Fourteen patients (10%) scored 90-100, 80 patients (56%) scored 80-89, 42 patients (30%) scored 70-79, and 6 patients (4%) scored less than 70.

We conclude that patients who score grade 1-3 of American Society of Anaesthesiologist and are mobile preoperatively outside their own home either independently or with one stick are better treated with HAC coated bipolar hemiarthroplasty with extra benefit of easy and quick conversion to total hip replacement if required in future.


RG Kakwani G Benke

Introduction: The aim of this study was to study the intermediate term (5-10 year) results of the ‘Metasul’ type of metal-on-metal hip arthroplasty.

Method: A prospective analysis was performed of the clinical and radiological findings of the patients who underwent the ‘Metasul’ hip arthroplasty by the senior author (Mr. Benke). The clinical evaluation was performed with the Charnley’s modification of the Merle d’ Aubigne scoring system as well as the Oxford Hip Scoring Sheet. All the patients operated from February 1995 till July 2000, were included in the study. Of the total of 99 patients, 5 patients died prior to the final review and 4 were lost to follow-up. The final study group hence contained 90 Hip Arthroplasties in 77 patients.

Results: The results were analysed using the Charnley categories, and as expected the patients of Category ‘A’ achieved the best final results with the d’Aubigne score rising from 8.6 to 17.2 and Oxford scores of 5.7/60. The patients of Category ‘B’ had good results (Final Oxford score of 7.3/60, and d’Aubigne score of 16.9). The Category ‘C’ patients had moderate results with the d’Aubigne score of 15.1 and Oxford score of 17.7/60. Three patients needed revision hip arthroplasty for the following reasons: aseptic acetabular loosening (1), infection (1) and massive osteolysis (1).

Discussion: The clinical results obtained with the use of the ‘Metasul’ articulation are comparable to those obtained by the metal-on-polyethylene articulation. The clinical success, the retrieval data of low wear from laboratory studies and the historical data of 40 years with an absence of clinical consequences of elevated serum Co ion levels, encourages the use of this alternate bearing surface.


A.D. Gorva J. Metcalfe R. Rajan S. Jones J.A. Fernandes

Introduction: Prophylactic pinning of an asymptomatic hip in SCFE is controversial. Bone age has been used as evidence of future contralateral slip risk and used as an indication for such intervention. The efficacy of bone age assessment at predicting contralateral slip was tested in this study.

Patients and Methods: 18 Caucasian children prospectively had bone age assessment using wrist and hand x-rays when presenting with a unilateral SCFE. Patients and parents were informed about the chance of con-tralateral slip and risks of prophylactic fixation, and advised to attend hospital immediately on development of symptoms in contralateral hip. After in-situ fixation of the affected side prospective monitoring in outpatient department was performed. Surgical intervention was undertaken if the contralateral hip was symptomatic.

Results: Three children (2 boys) went on to develop to a contralateral slip at a mean of 20 months from initial presentation. 6 children (5 boys) were deemed at risk of contralateral slip due to a bone age below 12.5 years for boys and 10.5 for girls. Only one from this group developed a contralateral slip. The relative risk of proceeding to contralateral slip when the bone age is below the designated values was 1 (95% confidence interval of 0.1118 to 8.95). The sensitivity and specificity were 33% and 66% respectively. With positive predictive value of 15% and diagnostic efficiency of 61%.

Conclusion: Delayed bone age by itself is not a good predictor of future contralateral slip at initial presentation. Routine prophylactic pinning is not justified based on bone age alone, with the risks of surgical fixation it carries. Prospective long term longitudinal study is required.


D. Shukla

AIM: To study bone healing and infection incidence using Allograft bone in acute comminuted fractures in elderly.

METHOD: 21 cases of comminuted fractures of distal femur and proximal tibia requiring bone grafting at primary fixation between 1999 and 2004 were included. Out of 19 cases of proximal tibial fractures, 7 were Schatzker type III, 6 were type IV and 6 were type V. Mean patient’s age was 74 years. Rigid internal fixation with sterilized human Cadaveric allograft was used to fill the defect. No additional auto-bone grafting was done. All cases had 24 hours postop IV antibiotics and were followed up clinically and radiologically until the end point of union or nonunion.

OUTCOME: 20/21 cases had fracture union within expected duration. 83 years old patient with Supracon-dylar fracture of femur with DCS fixation, failed to unite at 12 months post op and required revision surgery.

20/21 cases had no superficial or deep infection. 62 years old patient with Schatzker IV tibial plateau fracture had deep infection requiring wound debridement and removal of implant which revealed unabsorbed allograft at one year post op which also cleared the infection.

CONCLUSION: Allograft bone graft can be a safe bone substitute for promoting bone healing in elderly patients in acute fracture management.

We recommend using allograft bone in elderly patients to reduce morbidity by avoiding one more surgery of obtaining bone graft.

Allograft bone in elderly used with internal fixation also provides a reasonable structural support along with it osteoinductive properties.


R Sreekumar R Venkiteswaran V. Raut

Introduction: Steroid Infiltration into arthritic joints are a common means of treating pain. They are also sometimes done to differentiate pain in the hip from the low back or knee. There are recent reports which suggest that the rate of infection in hip arthroplasty after injection is higher than in previously uninjected joints.

Methods: We performed a retrospective review of the notes of all patients who underwent hip replacements in Wrightington Hospital under the care of the senior author from 1997 to 2004. We identified all patients who had at least one year follow up after the procedure. The infection rates in the patients who had an injection of steroid into the joint prior to hip replacement were compared to those who had no such intervention.

Results: There were 589 patients who had a hip replacement in this period. Of these, 72 had a prior injection of steroid into the joint. In the injected group, there was no incidence of infection during the period of follow up. There was one case of infection in a patient who did not have an injection prior to the arthroplasty.

Discussion: Steroid injections are a valuable adjunct in the management of patients with arthritic joints. This review clearly identifies no increased risk of infection in patients who had the injection prior to the operation.


S Muthian G D Sundararaj V N Lee

This study was done to determine the effectiveness of percutaneous autologous bone marrow injection in fracture healing and to determine if centrifuged bone marrow is more effective in bone healing as compared to uncentrifuged marrow.

This is a randomized interventional trial of 106 patients who had bone marrow injection. The study was done in 2 parts. In the first part, 51 patients were divided into three groups – a) Fresh fractures,(within 6 weeks of injury) b) Delayed union – (8 to 12 weeks after injury) c) Non union – more than 16 weeks after injury. All patients in the first part of the study underwent percutaneous autologous bone marrow injection and were followed up at 6,8,10 and 12 weeks and every 4th week thereafter. Forty seven out of 51 patients united. The second part of the study was done to compare centrifuged and uncentrifuged bone marrow injections. Fifty five patients having either tibial or femoral fractures were divided into two groups, centrifuged and uncentri-fuged and appropriate marrow injection was done. All patients were followed up every 6 weeks till 36 weeks. 48 patients out of 55 united. Equal number of patients united in the centrifuged and uncentrifuged group.

We conclude that percutaneous autologous bone marrow injection is a simple and effective tool which can be used for fracture healing and centrifugation of bone marrow yields no added advantage in bone healing.


M Bhattacharyya B Gerber

Background: Acute rupture of Tendo achillis can be treated by open, percutaneous surgery and minimally invasive technique. Open method reported to have high complication.

Objective: We report the outcome and length of hospital stay with minimally invasive technique with achillion

Design: Non randomised prospective observational study form October 2002 to December 2005

Materials and Methods: 9 male non professional athletes of mean age 38 years (range 23-73) presented with closed rupture were treated surgically using achillon technique were treated with same preoperative cast, post operative orthosis and rehabilitation protocol. All the patients had suture removed at 10 days after the surgery and followed up at 3 weeks, 8 weeks, 12 weeks and 6 months and yearly.

Results: The average operating time is 38 mins [range 27-58mins]. Mean length of incision is 3.4cm. No patient had clinical DVT, sural nerve disturbance and failure of repair and no bed stay.

Summary: Achillion Method helps to repair tendon under direct visualization, preserving its vascularity. We found no complication in wound healing. This surgical technique reduces financial burden in terms of bed use and wound care to the care provider. Randomised control studies may be necessary to highlight potential cost effectiveness


V Leninbabu N Shenbaga T Howes B Komarasamy SV Shah

Background: Whether to cross match or simply group and save for a primary THR is still a matter of debate. The argument in favour of cross match being immediate availability of blood and against it being wastage of resources, underutilization of cross matched samples etc.

Patients & Methods: We retrospectively analyzed the records of 136 patients who underwent primary THR at Manchester Royal Infirmary in 2004.

Result: Of the 136 patients, 104 had 220 units of blood cross matched. The average blood loss was 520 mls. The average pre op. Hb level was 12.8 g/dl while the average post op. Hb levels at 1, 3 & 5 days were 9.4, 9.9 & 10.1 gms/dl resply. Blood loss in patients on pre op. anticoagulant treatment (n = 44) was 596 mls while in the rest, it was 502 mls. The drop in Hb levels between the 2 groups was 3.6 gms/dl and 3.1 gms/dl resply. Patients with drain had an average drop in Hb level of 3.5 gms while it was 3.1 gms in others. The overall transfusion rate was 43.7 %. The most common reason for transfusion was asymptomatic low Hb (< 8 g/dl). Out of the 220 cross matched units, 99 (44.8 %) were transfused. Various probabilities like Cross-match to Transfusion ratio, Transfusion Probability & Transfusion Index were used to find out whether the cross matched units are used effectively.

Discussion: The only factor which influenced the transfusion rate was pre-op. Hb value. 79 %of patients required transfusion when pre op. Hb level was < 12 gm/dl.

Conclusion: 1. Group & Save is a safe policy for primary THR’s 2. Cross match only for patients with Hb of < 12gms/ dl. 3. Consider oral/IV iron therapy, autologous blood transfusion and retransfusion drain 4. Use of Aprotinin and transanamic acid reduces bleeding during surgery.


M Yousuf Y K Shankarappa

The authors report their preliminary experience with a minimum of one year follow –up of hydroxyapatite coating as the means of fixation of the femoral head in hip resurfacing.

Between Dec 2003 and Dec 2004, of the 23 cases performed by the senior author,22 were available for follow up,15 were women (68.2%) and 7 were men (31.8). The femoral and acetabular components of the uncemented version of the CORMET 2000(Corin,Cire ncester,UK) were used. The surgical approach was the Hardinge approach in all cases. Patients were assessed pre-operatively for pain and function,using the Harris Hip Score. Post operatively they were assessed in clinic with x rays at 6 weeks,6 months and annually thereafter. X rays were evaluated for pre and post op neck shaft angle,giving an indication of varus or valgus placement of the head prosthesis. The lateral view was assessed to reveal anterior or posterior tilting of the prosthesis. Neck thinning was evaluated by measuring the ratio of the metal cup and bony neck diameters at the cup neck junction, recorded post op and at one year.

None of the femoral implants were placed in varus. Only one case had inferior notching, which had remodelled at one year. In the lateral view none of the cups showed a displacement of more than ten degrees in the AP direction. There were no stem lucencies or signs of femoral implant migration in any of the cases. None of our cases showed neck thinning (change in ratio greater than 10%). Uncemented femoral implant in a metal on metal resurfacing hip replacement appears to perform well and shows no catastrophic problems at the short term one year follow up. Longer follow up studies are necessary


H L George J Jalaludhin S P K Marapudi George A N Regi P Gopinathan

Objectives: To evaluate and compare the imaging of lumbar spinal canal stenosis using plain radiographs, CT-Myelogram and MRI.

Patients and Methods: Prospective study at Medical College Calicut during 2002-2004. 25 patients of age from 25 to 69 years, with clinical features of lumbar spinal canal stenosis were evaluated. Inter pedicular distance, anteroposterior diameter and thecal sac cross sectional area (IPD, APD and TSCA) were measured using plain radiographs, CT-Myelogram and MRI, in all 25 patients.

Results: Soft tissue compression evaluated as disc protrusion and ligamentum flavum hypertrophy detected in 20 patients by CT-myelography and 22 patients by MRI. Thecal sac cross sectional area at stenosed level were assessed and compared with CT- Myelography and MRI, out of 25 patients 10 and 11 patients were detected with significant narrowing by CT-Myelogra-phy and MRI respectively in which 2 cases of severe thecal sac compromise (< 76 mm2) detected by CT-Myelography and 3 cases by MRI. CT–Myelography detected one case of single level absolute stenosis (AP diameter of < 10mm), but none of the cases were detected by MRI or Plain radiography. Relative stenosis (AP diameter of 10-12mm) at single level detected in 6 cases by CT–Myelography, in 4 cases by MRI and in 3 cases by plain radiography. Relative stenosis at multiple level detected in 3 cases by CT–Myelogra-phy, in 4 cases by MRI and in 6 cases by plain radi-ography.4 cases of multilevel absolute stenosis were detected by all 3 modalities.

Conclusions: CT- Myelographic measurement are well correlating with clinical symptoms and MRI findings. Bony Canal measurements obtained by CT- myelogra-phy are superior to same measurements obtained by MRI. Thecal-sac cross sectional area measurements obtained by CT-Myelography is comparable with that of MRI, even though soft tissue involvement in lumbar spinal canal stenosis is more clearly detected by MRI. In comparison of AP diameter taken by plain radiograph and CT- Myelography, X-ray measurements shows only 50-60% accuracy. AP diameter in CT- Myelography and MRI were comparable, when the thecal-sac cross sectional area measured by MRI taken as gold standard (using Karl pearsons correlation coefficients). CT-Myelography shows sensitivity of 92% and specificity of more than 96%.


R Rambani MS Shahid

Unilateral musculoskeletal below knee injuries occur with great frequency. Patients who cannot bear weight on an injured limb usually mobilise with standard crutches. However when the patient also has an upper limb injury, mobilisation may be impossible and can result in a lengthy in-patient stay. We present its value in facilitating early discharge in patients with both upper and lower limb injuries. We show the cost benefit of the saving in in-patient stay that the hands free crutch provides. We present our experience in which this innovative crutch was used and discuss the potential of this device to be used more often in orthopaedic surgery.


R. Wharton J.H. Kuiper C. Kelly

Objective: To compare the ability of a new composite bio-absorbable screw and two conventional metal screws to maintain fixation of scaphoid waist-fractures under dynamic loading conditions.

Methods: Fifteen porcine radial carpi, whose morphology is comparable to that of human scaphoids, were osteotomized at the waist. Specimens were randomized in three groups: those in group I were fixed with a headed metal screw, in group II with a headless tapered metal screw, and in group III with a bio-absorbable composite screw. Each specimen was oriented at 45° and cyclically loaded using four blocks of 1000 cycles, with peak loads of 40, 60, 80 and 100 N, respectively. In case of gross failure the number of cycles to failure was determined. Otherwise, permanent displacement at the fracture site was measured after each loading block from a standardized high-magnification photograph using image analysis software (Roman v1.70, Institute of Orthopaedics, Oswestry). Statistical analysis was by ANOVA and tolerance limits.

Results: Nogross failure occurred. Average displacements after 4000 cycles up to 100N were 0.05mm±0.03SD (headed metal), 0.15mm±0.16SD (headless metal) and 0.29mm±0.11SD (composite) and differed significantly (p< 0.02). Using tolerance limits, the data allowed us to predict that with 95% certainty, displacement in 95% of any sample fixed with a headed metal screw will be below 0.17mm, headless metal screw below 0.84mm, and composite screw below 0.76mm.

Conclusion: Comparing two types of conventional metal screws and a new composite bio-absorbable screw to maintain scaphoid fixation under cyclic loading conditions, we found small average fracture displacements for all three screws. Moreover, even following severe cyclic loading conditions, clinically meaningful displacements of more than 1 mm are highly unlikely for any of the three screws. We therefore conclude that a new bio-absorbable composite screw can serve as an alternative to conventional screws when fixing scaphoid fractures.


N Gogi S Joshy B Thomas A Mahale S C Deshmukh

Purpose of Study: To assess the efficacy of two-stage correction (skeletal traction followed by Partial Fasciec-tomy) in treating severe Dupuytren’s contractures.

Material, Methods and Results: We retrospectively reviewed sixteen fingers in fifteen patients with severe Dupuytren’s contracture (Tubiana Grade III/IV), operated between April 2000 and July 2005. The mean age was 58 years (27 – 82 years).

All patients underwent an initial application of Orthofix external fixator with pins in the proximal and middle phalanx. The patients were advised to gradually distract the device 3-4 times a day, for two weeks. They were then brought back for removal of fixator and partial fasciectomy with closure of skin by V-Y plasty.

The results were assessed in thirteen patients, as two were lost to follow-up. The mean follow-up period was 30 months (6 – 64 months). The total mean preopera-tive extension deficit improved from 130 degrees to 38 degrees postop.; PIP joint deformity improved from a mean of 77 degrees to 33 degrees postop. and the mean TRAM (Total range of active movements) improved from 108 degrees to 165 degrees.

Functional assessment was done using Michigan Hand Outcome Questionnaire. Overall improvement in hand function was from a preoperative 34% to a postoperative 89%.; aesthetic improvement from a preop. of 46% to a postop of 81% and pain improvement from a preop of 66% to a postop of 96%.

One patient had recurrence, one had features of RSD (Reflex Sympathetic Dystrophy) and one had to undergo amputation due to poor tolerance and persistent infection.

Conclusion: Severe Dupuytren’s contracture is a challenging deformity to deal. The two-stage correction may be considered as an alternative method of treatment in cooperative patients. Our study has shown promising results with good patient satisfaction


R. Kakar H. Sharma I. Cartlidge

Background: Extraarticular distal radius fracture is the second most common osteoporotic fracture seen in the elderly patients.

Purpose: To establish relationship between radiological parameters and final functional outcome in conservatively treated displaced extraarticular distal radial fractures in elderly patients.

Methods: Twenty-two wrists with displaced extraar-ticular distal radial fractures in twenty sedentary, low demand elderly patients treated with manipulation under anaesthesia and plaster application between May 1999 and June 2000. The case notes and radiographs of these patients were assessed retrospectively and subjective outcome was evaluated with validated DASH Questionnaire at 3 years post- reduction. Overall satisfaction, ability to return to the previous level of activity and concern over wrist appearance was further analyzed. Only those patients with more than 5 mm of shortening and more than 15 degrees of dorsal angulation at initial radiographs were included. Results were analysed using Pearson Correlation Sig.(2 –Tailed) formula.

Results: There were 16 female and 4 male patients with a mean age of 71 years. The mean follow-up was 3 years. DASH score of less than 25 was seen in 14, between 25-50 in 3 and between 50-75 in 3 patients with mean of 21.426 and standard deviation of 22.353. Despite residual deformity in some patients, there was high degree of patient satisfaction consistent with low level of DASH score found in 71% patients. It was also noticed that Males in the study group were younger and have lower dash scores. Patients with more than 5 mm of shortening and more than 15 degrees of dorsal angu-lation at initial radiographs showed no adverse correlation with subjective outcome. Statistical analysis of the results confirmed that higher the age lower the DASH score there by better functional result.

Conclusion: It was noted that the higher the age the lower the dash score. Radiological picture and functional outcome are found to be two independent variables in the elderly subgroup of patients with displaced extrar-ticular distal radius fractures. Nonoperative treatment yields satisfactory results with high patient satisfaction rate and is advocated in elderly patients.


A Waheed KI Eleftheriou H Khairandish A Hussein L James H Montgomery FS Haddad RB Simonis

The aetiology and pathophysiology of non-union is still unclear, but in this condition there is an abnormal bone metabolism. The paracrine matrix RAS has been implicated in the regulation of bone remodeling and injury responses, possibly via its effects on kinins. The influence of the local RAS or the genetic influence of the ACE/ BK2R genes to bone remodelling may thus be central to the disorder, or augmented in these conditions. We thus compared the distribution of the ACE I/D and BK2R “+9/-9” functional polymorphisms in patients with non-union and compared them to appropriate control.

Gene analysis was performed on buccal cells collected from all subjects and the data was analysed for 59 patients (46 males, 13 females; mean age 40.1±15.7 years) with non-union and 81 control subjects (49 males, 32 females; mean age 51.4±22.81 years. The overall genotype distribution was consistent with Hardy-Wein-berg equilibrium for the overall and individual groups for ACE (p0.16), B1BKR (p0.68) and B2BKR genotypes (p0.12)

As the -9 allele is associated with greater gene transcription and higher mRNA expression of the receptor we combined the -9/-9 homozygous and -9/+9 heterozygous groups and compared them with the homozygous +9/+9 groups. This showed a significant difference between the non-union and control groups, with the +9/+9 homozygous being less prominent in the former (p=0.03)

The B2BKR -9 allele is associated with the incidence of non-union in fracture healing, in this first study to address this question. We found no association with either the ACE I/D or B1BKR genotypes.

In conclusion, with previous findings that the absence of the -9 allele of the B2BKR +9/-9 polymorphism is associated with greater gene transcription and higher mRNA expression of the receptor our findings are suggestive that increased BK activity via the B2BKR may predispose to the development of non-union.


S Patel R Kulshreshtha A Arya D Ilias J Compson D Elias

BACKGROUND: With the improvement of the ultrasound technology, there has been an increasing ability to image the soft tissues of the hand and wrist. This means structures such as tendon, ligaments and soft tissues can be visualized both statically and dynamically.

AIM: The aim of our study was to audit the types of cases who have undergone ultrasound imaging in different hand conditions in last two years.

MATERIAL AND METHODS: We studied 123 ultrasound and looked for its use in different hand and wrist conditions. These were categorized in different groups such as diagnostic, anatomical and therapeutical.

RESULTS: In our 123 patients, 49 had lumps out of which 30 ganglions, 7 vascular, 4 glomus tumours, 2 granulomas, 4 neuromas, 1 lipomas and 1 sarcoma. In another 30 patients it was useful to diagnose tendon conditions such as inflammation, rupture, triggering. Furthermore, in 31 patients it was used for diagnosis of carpal tunnel syndrome. In addition, it was used for many miscellaneous conditions.

DISCUSSION: Ultrasound is a useful tool for imaging of soft tissues in the hand. It can differentiate between solid and cystic swellings and can be used to aspirate and / or inject the later. It allows dynamic viewing thus making it an important tool in assessing complex tendon problems. We feel that it is a convenient, dependable and useful aid in diagnosing various hand conditions and should be available for widespread use.


S Masud A Mehra JC Clothier

To assess if paediatric patients are getting adequate gonadal protection whilst undergoing pelvic X-rays.

A retrospective study of 100 AP pelvic X-rays in 62 consecutive paediatric patients was performed. All children 16 years and under (mean = 8 years) who had an AP pelvic X-ray at our institution between 1st April 2004 and 1st July 2005 were included in the study. When reviewing the X-rays, the manufacturer’s guidelines for ideal shield size and position were strictly followed to assess whether adequate gonadal protection was being achieved (the lead shield must be completely covering the true pelvis in girls and the scrotum in boys). A subsequent questionnaire survey involving 20 radiographers was carried out.

In 78 cases gonadal protection was inadequate. This was unrelated to the child’s age or sex. In 72 cases shield position and in 11 cases shield size was incorrect. The survey showed that 40% of radiographers believed that the gonadal shield was either difficult to use or had a poor design. Twenty percent felt they had received inadequate training.

Gonadal shields reduce radiation exposure of the reproductive organs during pelvic X-rays. Many designs are available on the market but not all designs function adequately. Our study showed that a poor design of gonadal shield can cause unnecessary radiation exposure. We present this audit to make people aware of this poor design and recommend that a detailed market survey prior to buying such equipment and subsequent training of staff in its proper use must be carried out.


S R Sampalli P Cnudde

Abstract: Between 1997 to 200, 230 patients underwent primary cemented total hip replacement using the ULTIMA Cobalt alloy, collarless femoral stem and UHMW Polyethylene Cup.184 Patients were available for review with an average follow up of 48 months. The average age at operation was 69 years. The majority of the patients were female (58%). Most of the surgeries were performed by a Consultant Surgeon(91%). Cementing technique was satisfactory in majority with a cement mantle of Grade B noted in 81% of the patients. The position of the femoral stem was noted to be in neutral position in the majority of the patients (76%) with varus and valgus positions in 21 % and 3 % respectively. There was radiological evidence of loosening in 39% of the patients at the follow up out of which a quarter of patients were symptomatic clinically. Subsidence of the femoral stem was noted in 30% of the patients out of which majority 71% had evidence of loosening. About 8 patients had undergone revision or waiting revision surgery. Revision surgeries were performed between 3 to 7 years following the primary surgery with a peak in the 5th year


Y R Shah F Zafar J A Fairclough

Purpose of study: To assess the effect of 18-month waiting list, on the subsequent requirement of knee arthros-copy.

Materials and methods: Medical records of 310 patients with knee pain, who had been placed on the non-urgent arthroscopy waiting list in 2003, were assessed. Diagnoses and the grade of doctor placing the patients on the list were also noted. The percentages of patients undergoing surgery as planned, as well as of those being cancelled were looked at.

Results: 61% of patients underwent knee arthroscopy as planned. 12% considered their symptoms insignificant as to require operation. 11% wanted a later operation date because of personal reasons, 7% had their surgery privately or had been expedited through the waiting list scheme because of deterioration in their condition but remained on NHS waiting list, and 9% patients had their surgeries postponed because of other medical reasons.

Conclusion: For a group of patients having been placed on an 18-month waiting list for knee arthroscopy, 40% did not subsequently have surgery within the NHS setting, as planned initially.


RK Trehan A Shetty V Naidu

We wish to report the use of a modified ‘Y-V’ medial capsular repair in association with Chevron osteotomy fixed rigidly with Barouk screw for Hallux valgus in 45 patients (52 feet) aged 16 to 70 years (mean 47 years) between July 2004 and September 2005. All patients were retrospectively reviewed by questionnaire, physical examination (American Orthopaedic Foot and Ankle Society score) and comparison of preoperative and post operative x rays.

Using this technique none of the patients required additional immobilization apart from wool and crepe bandage following surgery. All osteotomies healed without any problem. There was no deep infection reported in this series. There were two superficial infection treated with oral antibiotics. There is no recurrence of deformity so far. At an average of six months follow up American Orthopaedic Foot and Ankle Society score improved significantly. Intermetatarsal (IM) angle and the hallux valgus (HV) angles were also improved considerably.

Stabilization of Chevron osteotomy with k wires, plaster of Paris is well known but these techniques have problems of infection and stiffness. Osteotomies carried out without any stabilization has high recurrence rate. Fixation of osteotomy with Barouk screw is a very simple procedure, which not only gives stability and compression to osteotomy but also reduces need for any plaster immobilization thus speed up rehabilitation. This also gives extra confidence to surgeon to allow patient for early weight bearing and mobilization.

We also recommend the use of modified ‘Y-V’ medial capsular repair to correct the hallux valgus angle and reduce the meta tarso-phalangeal joint leading to reduction in possibility of recurrence.


A. Shepherd P. Cox

The standard plane imaging of Graf and the dynamic methods of Harcke are well established methods in assessing hip dysplasia but give limited information in the flexed-abducted treatment position used in the Pavlik harness. The femoral head may sit on the edge of the acetabulum in a flexed position and only reduce when the hips are abducted. This may mean that hips, which reduce when abducted in the Pavlik harness, appear subluxed when scanned in neutral abduction. Harness treatment may thereby be abandoned prematurely due to the failure to confirm reduction. This study identifies ultrasound landmarks on an anterior hip scan which could be used to confirm reduction of the hip in Pavlik Harness.

Hips of a newborn piglet were scanned, imaged with magnetic resonance and x-rayed both before and after anatomical dissection. Radiographic markers delineated the position of the tri-radiate cartilage and potential ultrasound landmarks identified to help confirm hip reduction in the flexed-abducted position. Porcine imaging was then compared with that of a human newborn.

The porcine model corresponded well to human imaging and we were able to establish a landmark, the “Ischial Limb”, which corresponds to the ossification front delineating the posterior ischial edge of the tri-radiate cartilage. This could clearly be seen on anterior hip ultrasound of both the porcine and human hip. This landmark can be used to confirm the hip is reduced by reference to the centre of the femoral head.

We would recommend anterior hip scanning using the “Ischial Limb” as a reference point to confirm hip reduction in Pavlik harness. This simple method is a useful adjunct to conventional ultrasound scanning in the harness treatment of hip instability.


J. Charity E. Tsiridis D. Gusmao J. Howell M. Hubble J. Timperley G. Gie

Introduction: Concerns have been raised regarding both the risk of non-union, and the ability to achieve stability with the use of an ETO in combination with cemented femoral impaction allografting.

Objective: To evaluate the long term follow-up results on all patients using ETO with Impaction Grafting.

Material and Methods: Eighteen patients with a mean age of 61 years were prospectively evaluated. The mean follow-up was 60 months (13 – 114). Charnley-D’aubigne-Postel scores, stem length, ETO length, ETO healing and complications were recorded. No patient was lost to follow-up.

Results: In 13 cases the femur was classified as Paprosky type 3B, in 1 case type 3A and in 4 cases type 4. The mean femoral diameter was 25 mm and the mean osteotomy length was 130 mm. In all cases the stem bypassed the distal osteotomy site with a mean of 58 mm (mean ratio to femoral diameter 2.3). Radiological and clinical healing were achieved in all cases at a mean of 6 months. No evidence of graft-host subsidence or lack of femoral stability was observed.

Conclusion: Further to bone augmentation, Impaction Grafting when performed appropriately protects the osteotomy site from cement interposition leading to a secure bony union of the osteotomy site. The distal osteotomy site should be bypassed by at least 2 ipsilateral femoral diameters. The presence of an ETO did not appear to affect graft stability.


R. Yarlagadda A. Clarke J. Keenan

We prospectively studied 15 proximal tibial and 30 distal femoral fractures treated with the Less Invasive Stabilisation System for periarticular fractures about the knee.

Of these 45 fractures, one patient returned to Russia and was thus lost to follow up. The mean age of the remaining patients was 64.4 years (range 15–94 years). There were 26 females and 13 males. All fractures were classified according to the AO classification.

We found the use of temporary external fixation and mobile radiolucent wedge leg supports very helpful during surgery for these cases. We developed an increasingly aggressive postoperative mobilisation regime with increased experience of using this fixation technique.

Functional assessment was performed using the Schatzker and Lambert scores. The average time to union was 14.78 weeks (range 10– 28 weeks). 43 fractures have united with one fracture showing signs of delayed union. There were two implant failures, two deep vein thrombosis and two compartment syndromes. Five patients died of unrelated causes and without problems relating to their fracture.

We conclude that the Less Invasive Stabilisation System is a satisfactory method of treating these complex and difficult fractures about the knee with a high rate of union and good functional outcome.


S.A.C. Morris M.J. Walton S. Mehendale C. Brown A. Omari B. Squires

The use of arthroplasty registers was initiated by Sweden in 1979. The practice has been adopted globally as best practice for recording the outcome of joint replacement surgery and for identifying early problems. The Trent and Wales Arthroplasty Audit Group began in 1990 and have recently produced outcome results. We have analysed the short-term outcomes of arthroplasty procedures at a DGH in order to assess comparability to this “gold-standard”.

In 2004, 231 primary arthroplasties were performed, by the two senior authors, at Musgrove Park Hospital (149 THR, 82 TKR). There was an overall complication rate of 8.7%. There was 1 periprosthetic infection in a THR that required revision (0.043%). 9 patients developed wound complications, principally superficial infections and haematoma formation. 2 patients, both THR developed, thromboembolic complications, one DVT and one pulmonary embolus. There was one periprosthetic fracture around a THR. The dislocation rate for THR was 3.35% (5/149). 3 of these were performed through a posterior approach and 2 through an anterolateral. 3 have required revision surgery.

We have demonstrated comparable results following joint arthroplasty to published teaching hospital series. We have shown that adequate infrastructure can exist in smaller units to accurately record outcome data following arthroplasty surgery.


S. Dixon T Bunker D Chan

Collecting outcome scores in paper form is fraught with difficulty. We have assessed the feasibility of and patient’s attitude towards entering scores using a touchscreen.

A touchscreen was installed in the orthopaedic outpatient clinic. If relevant, patients were asked to complete either an Oswestry Disability Index (ODI) or Oxford Shoulder Score (OSS) using the screen. Patients were given written instructions and their hospital number by the receptionist who had no further input. Scores were completed with two identifiers. A paper questionnaire was used to assess computer experience and attitude towards the touchscreen.

Results: 1377 patients, average age 51 successfully completed a score in the first 12 months. 1/3 were over 60. 93% correctly entered their hospital number and date of birth, falling to 85% in patients over 70. All patients were identifiable. The average time to complete the scores was 4 minutes rising with age.

Of 170 patients completing the questionnaire, 1/3 had little or no experience of computers and 1/3 were over 60. 93% of patients were willing to repeat the score using the touchscreen to monitor progress. 2/3 found it easier to use than expected. Only 10% would prefer a paper score. These results were maintained among patients over 60. Only 2 were unable to complete the score and 80 % of those potentially eligible did so. The remainder were called to clinic before the touchscreen was free.

Conclusion: Orthopaedic outcome scores can be collected in very large volumes using a touchscreen. Data is then in an immediately usable form. The method is acceptable to the patients, independent of age and computer experience. Even in the oldest patients the accuracy is higher than for paper versions of the score. Combined with operative data, this simple method has the potential to provide a very powerful audit tool indeed.


P.J. Yates B.J. Burston G.C. Bannister

The collarless polished tapered stem (CPT) is a double tapered, cemented femoral component designed for primary hip replacement and as a revision stem for impaction bone grafting. We report outcome at a minimum of 10 years (mean 11 years 1 month).

Of 191 consecutive primary hip replacements in 174 patients, implanted using contemporary cementing techniques, 63 patients died before 10 years (68 hips). None of these stems had been revised or had radiological signs of failure at their last follow-up. Only one patient (two hips) was lost to radiological follow-up, hence complete radiological data was available on 121 hips and clinical follow-up on 123 hips. The fate of all the hips is known.

Survivorship with revision of the femoral component for aseptic loosening as the endpoint was 100%. The Harris hip scores were good or excellent in 75% of the patients with a mean of 86. All the stems subsided vertically within the cement mantle at a mean rate of 0.18mm per year, stabilising to a mean total of 1.95 mm (0.21–24 mm) after a mean of 11 years 1 month. Unlike Exeter stems there was no change in the alignment of the stems. There was excellent preservation of proximal bone and an extremely low (< 2%) incidence of loosening at the cement bone interface.

The study confirms that the CPT subsides within the cement mantle, but without failing. It performs at-least as well as the best stems currently available.


V. Siewrattan M. Divekar S. Parsons

A prospective audit was conducted at an associate teaching hospital in the south west to assess the outcome of operative treatment of ankle fractures of all patients over the age of 50 years in the last 2 years.

The aim of the study was to assess whether change in timing of surgery for ankle factures in accordance with the CEPOD guidelines has affected the outcome in terms of early complications. This is a follow up paper to the one published from this institution in 1994 (data 1988 to 1989). Since then the CEPOD rules have led to changes in theatre protocols, so very few ankles are fixed out of hours. Over this period there has been the emergence of MRSA which was not a problem in the 1990s.

We retrospectively reviewed the notes and x-rays for 107 consecutive patients older than 50 years who had their ankles fixed over a period of 2 years spanning 2003 to 2004. Our series had 12.1% incidence of clinical infections, 15.9% delayed wound healing as compared to 1.8% and 5.2% in previous publication from this institution. In our study 17.7% of ankles were fixed within 24 hours as opposed to 84.2 % in the previous paper. All of the infected wounds (100%) occurred in patients who had their operations 48hrs or more post injury. We also came across 2 cases of MRSA infection in our series.

We are concerned that changes in CEPOD rules as well as new hospital practice has resulted in delays in time to fixation. This seems to be the only variable to result in increased infection rates and delays in wound healing leading to increase in hospital stay and reoperations.


U. Masood D.H. Williams M.R. Norton

Scarf osteotomy improves hallux valgus and can be used for deformities with large intermetatarsal angles. It is designed to minimise shortening of the first ray. The aim of this radiographic analysis was to assess the outcome of patients undergoing Scarf osteotomy at the Royal Cornwall Hospital.

The initial 18 consecutive cases performed by the senior author were analysed using the guidelines recommended by the American Foot and Ankle Society. Standardised anterior-posterior radiographs of the foot were compared pre-operatively and at 6 weeks postoperatively. Measurements of the intermetatarsal angle (IMA), hallux valgus angle (HVA), joint congruency angle (JCA), distal metatarsal articular angle (DMAA), sesamoid position and metatarsal length were used to assess any improvement.

The results showed a significant median reduction of the IMA of 70, HVA of 180, JCA of 50, and the DMAA of 30 (all p values < 0.001). The medial sesamoid position in relation to the first metatarsal also improved from a mean value of 2.28 to 1 using the American Foot and Ankle Society grading system. There was no shortening of metatarsal length as measured using the Hardy and Clapham method.

This study shows that the radiographic outcome of Scarf osteotomy at the Royal Cornwall Hospital compares favourably with that found in the literature. It provides effective correction of moderate to large intermetatarsal angles.


A. Khan P. Yates A. Lovering G.C. Bannister R.F. Spencer

Aim: Avascular necrosis of the femoral head is believed to play a role in failure of the femoral component in metal on metal hip resurfacing arthroplasty. The purpose of our study was to determine, prospectively, femoral head perfusion during hip resurfacing arthroplasty in the posterior and anterolateral approaches.

Methods: 20 hip resurfacing arthroplasties were performed in 19 patients between September 2005 and April 2006. Patients were divided into two groups according to approach. An equal number of operations were performed by two different surgeons; one using the extended posterior approach and the other an anterolateral approach. Intravenous cefuroxime was administered in every case following capsulectomy and relocation of the femoral head. After 5 minutes the femoral head was dislocated and prepared as routine for the operation. Bone from the top of the femoral head and reamings were sent for assay to determine the concentration of cefuroxime.

Results: The concentration of cefuroxime in bone was significantly greater when using the anterolateral approach (mean 15.7mg/kg; CI 12.3 to 19.1) compared to the posterior approach (mean 5.6mg/kg, CI 3.5 to 7.8; p< 0.001). In one patient, who had the operation through a posterior approach, cefuroxime was undetectable.

Conclusion: The posterior approach is associated with a significant reduction in the blood supply to the femoral head during hip resurfacing arthroplasty. This may be a cause for avascular necrosis and potential failure of the femoral component in this procedure.


N. La Hei I. McFadyen M. Brock J. Field

Magnetic Resonance Imaging (MRI) is gaining popularity for the evaluation of acute wrist injuries, but findings may be confusing with uncertain clinical significance. The presence of bone marrow oedema but no fracture following trauma has been described in the knee and referred to as a bone bruise. The clinical implications of similar findings in the scaphoid have not been described.

This study aims to describe the clinical and radiological findings of an acute wrist injury known as the scaphoid bone bruise. An MRI classification is proposed, and the outcome described.

Between April 2000 and October 2004 all patients who underwent MRI scanning following an acute injury for suspected scaphoid fracture were considered for this study. The scaphoid bone bruise was treated with a degree of caution and the injured limb placed in a below elbow cast for six weeks. Review was arranged at three months when, if symptomatic, a further MRI was performed. A descriptive grading system depending on the extent of the bone bruise was developed.

41 patients were included in the study. At three months 26 were asymptomatic. Seven defaulted from follow-up. Eight patients were still symptomatic and underwent further MRI scan. The bone bruise was classified into four grades according to the degree of oedema found on MRI. Seven patients were grade 1, 18 patients were grade 2, 11 grade 3, and the remaining five grade 4. Of the eight patients who underwent repeat MRI scanning all showed improvement of the bone bruise. At six months only 2 patients remained symptomatic.

While healing around the knee is seldom a problem, the possibility that scaphoid bone bruise may be a precursor to scaphoid non-union needs to be excluded. This study suggests that scaphoid bone bruise is a benign injury with predictable recovery over time and is unlikely to result in long-term morbidity in the form of non-union. It may be feasible to mobilise these injuries much sooner. However, further study with longer follow-up and repeat MRI scans is necessary to be confident that caution about these injuries is unnecessary.


A.M. Ashmore C. Gozzard N. Blewitt

Aims: To review the results from a series of GSB III total elbow arthroplasties performed at an independent centre.

Between 1996 and 2004, the senior author performed 58 total elbow arthroplasties in 44 patients (10 males, 34 females) using the GSB III implant. These were reviewed and the outcome assessed through the use of a patient-answered questionnaire and clinical and radiological review. Mean age was 65 (49 to 84 years). Indications for surgery included rheumatoid arthritis (46 elbows) and post-traumatic osteoarthritis (11 elbows). Mean F/up was 4.1 years (0.8 to 8.5 years). Four patients had died (six elbows) and four patients (four elbows) were unavailable for review. Two of the implants had been revised (1x aseptic loosening, 1x deep infection), leaving a total of 46 elbows available for review. The survival rate at a mean of four years was 98% with aseptic loosening as the endpoint.

Complications included one case of intraoperative fracture and one persistent ulnar neuritis. Overall patient satisfaction was high. The mean Mayo Elbow Performance Score was 83 out of 100 (range, 34 to 100) and mean Liverpool Elbow Score was 8 out of 10 (range, 1 to 10).

Conclusion: Previous studies of outcome following total elbow arthroplasty using the GSB III elbow prosthesis at independent centres have shown satisfactory results, but have looked at small groups of patients. Our results offer more robust data to show that the medium term outcome following total elbow arthroplasty using the GSB III prosthesis is satisfactory.


J. Ciampolini Tore Heier P Evans

Background: Independent Sector Treatment Centres (ISTC) are now providing significant volumes of elective orthopaedic care in the UK. They have been the subject of considerable publicity. The ISTC in Plymouth was the first newly built orthopaedic centre to open.

This paper describes the methods of working and analyses the early results of nearly a thousand joint replacements implanted between May 2005 and April 2006. It is the first set of such results to be become available.

Methods: Data on each case was collected prospectively and entered into a database. This included demographic information, surgical and implant data, blood loss and transfusion requirements, length of stay, patient satisfaction, readmission rate, complications and mortality. One hundred consecutive postoperative hip replacement x-rays were scored by an independent orthopaedic surgeon. The alignment of one hundred consecutive postoperative knee x-rays was evaluated by long leg views. Comparison is made to published UK and international data.

Results: Ongoing

Conclusion: Ongoing


R. Badge E. Imran D. Chan

Introduction: The conventional approach to spinal malignancy is via intralesional piecemeal resection but the incidence of local recurrence after surgery has been increasing as survival of patients getting prolonged due to advance adjuvant treatment TES is devised to minimize the incidence of local recurrence in malignant spinal tumours. The purpose of this study is to analyse whether the radical procedure like TES is justifiable in solitary metastasis or not

Material & Methods: We analysed 6 patients who undergone surgery for metastases of spine secondary to renal cell carcinoma between1996 and 2005 out of which 4 had TES for solitary intraosseous thoracolumbar lesion. They include three men and one woman ranging an age from 51 to 64 years. Common presenting complaints were intractable back pain dependent on opiates and progressive neural deficit. Four patients had localised intraosseous thoraco-lumbar lesion. The extent of spinal lesion was assessed with X-rays, CT scans and MRI for all patients. All patient’s prognosis was analysed by Tokuhasi Scoring System.3 patients had pre-op embolisation.4 patients with solitary intra-osseous metastasis underwent radical surgery in the form of total vertebrectomy and 3- column stabilisation of spine. Total surgical time was between 9–13 hrs and total blood loss between 4–11 Litres.

Results: None of the patients had surgery related major complication. No external brace used for mobilisation. The surgical outcome assessed by the pain, severity of paresis and the ability to walk before and after surgery. All patients followed up regularly to detect local tumour recurrences and position of implant. None of the patients with TES shown signs of local recurrence The follow up period for the surviving patients ranged from 9 to 32 months after TES. One patient died 9 month post-op due to widespread metastasis.

Conclusion: TES offers the most aggressive mode of treatment for the solitary metastasis of Thoraco-Lumbar spine secondary to Renal Cell Carcinoma. Considering the technical demands and potential risks of TES, the indication for TES with spinal metastasis should be limited to the cases with solitary intra-osseous lesions in malignancies with good prognosis.


G. Wansbrough P J Cox

Open reduction of DDH is indicated in late presenting cases and those who fail Pavlik Harness treatment, if closed reduction is unsuccessful. Recognised techniques involve excision of the ligamentum teres to allow maximal medialisation of the femoral head into the acetabulum.

We describe a new technique in which the ligament’s femoral attachment is preserved and the medial end is passed through the incised transverse ligament. Gentle traction on the medial end is used to aid reduction and when sutured to the anterior capsule, the reduction is stabilised.

We present our operative experience and early follow up of 8 cases.


JJ Matthews B Guhan JN Dainton PM Hutchins

Introduction: The long term results of a previously published (J Shoulder Elbow Surg. 2002 Sep–Oct; 11(5):486–492) series of 44 primary Souter-Strathcyde total elbow arthroplasties performed on 36 patients with rheumatoid arthritis by a single surgeon in a district general hospital are presented.

Methods: Of the 36 patients 14 patients had died leaving 22 patients or 28 elbows that could be followed up with a mean follow up of 11 years (range 9.7–17.8 years). Patients were followed up in research clinics. They underwent plain radiographs and clinical examination. The notes of the deceased patients were reviewed.

Results: In the surviving patients 60% reported complete freedom of pain, 28% mild intermittent pain and 11% moderate pain. The mean range of motion at follow up was 91 degrees (range 30–130 degrees). This represented a mean gain of 15 degrees of flexion, but only a 1 degree gain in extension. Fourteen elbows had a range of motion of 100 degrees or greater compared with 9 before surgery.

In the deceased patients 2 patients had undergone revision and the remaining patients had died of causes unrelated to the surgery with the prosthesis intact. There was 1 permanent ulnar nerve palsy and two deep infections one requiring debridement. Eight of the original 44 primaries required revision, 3 for fractures and 5 for loosening.

Discussion: In patients with rheumatoid arthritis and low functional demand, the Souter-Strathclyde total elbow arthroplasty performs well in abolishing pain and increasing independence in carrying out the activities of daily living.


Mr K Saeed Lt Col PJ Parker

Hip osteoarthritis is uncommon in active military personnel but can be extremely debilitating. Previously in such cases total hip replacement was usually delayed as long as possible. The two main reasons for such reluctance were that these persons would be graded P7 Permanent after total hip replacement and that the amount of physical activity an active military person does would lead to early loosening of implant and revision surgery. Resurfacing Arthroplasty has allowed us to take an earlier and more interventional approach in younger active patients.

We describe our early results of 18 hip resurfacing operations in active serving military personnel. Average age was 48 years. All 18 were done in MDHU Northallerton by one in-service orthopaedic consultant in 2004 and 2005. There were no serious complications; average length of stay was 5.5 days. Specifically there were no fractured necks of femur and there were no early signs of component loosening. Final grading after six months was P3.

Hence we now recommend that in selected active military personnel where anatomy permits early hip resurfacing should be considered rather than a conventional hip replacement.


Major M Butler Mr S W Parsons

Introduction: The term dorsal bunion describes a condition characterised by a swelling in the region of the 1st MTPJ with an elevated first metatarsal and a flexed toe. The literature available concentrates on the forefoot aetiology- no author has yet documented the role of the hindfoot in its pathogenesis.

Methods: We have conducted a review of 28 consecutive patients, excluding those with hallux rigidus collected prospectively in the course of a full-time foot and ankle practice between 1996 and 2005. All of the patients have been examined with respect to their primary pathology leading to the dorsal bunion and had the mobility and position of the hindfoot assessed.

Results: In the series of 28 patients, the average age was 31.6 and there were 18 male and 10 females. Every patient examined had either a rigid hindfoot or stiffness contributing to a failure to correct for abnormal forefoot position.

Conclusion: The causes of dorsal bunion may be considered to be Primary (Hallux Rigidus) or Secondary (CTEV, neurogenic, iatrogenic, global forefoot supination).

It is the authors’ view that hindfoot stiffness in secondary cases of dorsal bunion causes an inability of the footto compensate for an abnormal position of the forefoot- the 1st ray must compensate by flexion of the hallux to allow the foot to adopt a plantigrade position.


Maj DJ Cloke H Watson S Purdy IN Steen JR Williams

Introduction: Shoulder pain represents a significant burden of disease in the general population, yet there is a lack of evidence about the effectiveness of routinely used interventions such as corticosteroid injection and physiotherapy.

Methods: Over a six-month period patients with “painful arc” of less than six months duration were recruited via their GPs.

Eligible patients randomised to one of four arms of the study: control (normal analgesia and/or non-steroidal anti-inflammatory medication), a specified and repeatable Exercise and Manual Therapy Package (EMTP), a course of up to three subacromial steroid injections or both the EMTP and the steroid injections. Follow-up was for 18 weeks, with postal questionnaire at one year.

The primary outcome measure was the Oxford Shoulder Score (OSS).

Results: 186 patients were referred, 112 were randomised. Mean age was 54.5 years. Ninety patients completed the trial. Sixty-two returned the follow-up questionnaire.

By analysis of covariance, no significant differences were found between the OSS scores or SF-36 (physical health total) at the beginning and end of the trial, or at one year. Two patients in the injection group went on to surgery, along with one each in the control and EMTP groups. No significant differences were found between treatment groups.

Conclusion: We have found no significant differences in outcome between steroid injections, physiotherapy, both treatments, and symptomatic treatment in a group of patients with early painful arc of the shoulder. Further, larger studies may be needed to find small differences in outcome between these treatments.


Mr J Millington L B Cannon

Osteochondral lesions (OCLs) of the talus are not uncommon, the diagnosis of which requires a high index of suspicion and is often delayed. The purpose of this presentation is to raise awareness and discuss treatment outcomes of OCLs.

All patient notes with a diagnosis of talar OCL over a 12-month period were retrospectively analysed. A telephone questionnaire was then performed in which patients were asked to compare current symptoms to pre-operative symptoms using a numerical scoring system.

There were thirteen patients with a mean age of 31. A history of trauma was present in eleven (85%) and all had activity related pain. OCLs were evident on plain radiographs in six (46%). The diagnosis was made in the remainder on MRI or at arthroscopy. Median time between initial orthopaedic assessment and diagnosis was 4 months (0–100). The OCLs were medial in six (46%) and lateral in seven (54%). Eleven patients were treated with excision and penetration of subchondral bone, 1 underwent open fixation and 1 had an isolated chondral lesion treated conservatively. Mean follow-up was 6 months (2–14). Seven (54%) had minimal or no symptoms and three (23%) only after prolonged activity. Ten (77%) were better than before surgery, one (8%) the same and two (15%) were worse. The three patients who were the same or worse had had a delay in diagnosis of over 12 months.

Patients with talar OCL often have persistent ankle pain which remains undiagnosed. Early diagnosis and treatment offers the best chance for a good outcome.


Major M Butler Mr MR Williams Dr E Traer Mr JN Keenan

Introduction: We report the early results of the hydroxyapatite coated, distally locking Cannulok revision hip prosthesis. The component was used to treat difficult periprosthestic and pathological fractures, often in the presence of aseptic loosening or infection in a group of elderly patients.

Methods: 16 patients with a mean age of 78 years underwent surgery by a single surgeon over a period of 3 years. No patients have been lost to follow-up and they have been followed up clinically and radiologically for an average of 24 months.

Results: The mean modified Merle D’Aubigne and Oxford Hip Scores were 14 and 23.6 respectively. These results are comparable to the published results for the previous uncoated version of the Cannulok hip, and other revision hip series.

Discussion: We believe the HA coated distally locked Cannulok revision hip implant provides a relatively simple and effective reconstructive option that can be used as an alternative to more extensive surgical options in elderly patients with periprosthetic fractures.


S. Manohar L Cannon

Cigarette smoking prior to and following foot surgery is well recognised as resulting in a higher complication rate. The purpose of this study was to determine the effectiveness of pre-operative counselling prior to elective hallux valgus surgery.

A prospective record of smoking histories was taken in all patients prior to surgery. They were counselled as to the increased complication rate and advised to stop prior to surgery and in the immediate peri-operative period. The mechanism of the increased complication rate was explained to improve their understanding to stop smoking. They were advised to see their GP for specific strategies and medications. Further smoking history was taken on admission and in review clinics. A telephone survey was then conducted to ascertain their smoking pattern following discharge from follow-up.

Forty-two patients underwent hallux valgus surgery over a 12 month operating period. Ten (23%) were recorded as smokers at the time of initial consultation. Most patients (80%) were unaware of the detrimental effects of smoking following foot surgery. Patient education was effective in providing an impetus to stop or reduce smoking in 6 (60%) patients pre-operatively. One further patient subsequently desisted from smoking following surgery. Only two patients had re-commenced smoking following surgery implying a long term change of behavior. Only one complication of a DVT occurred in a patient who continued to smoke.

This small study has shown the effectiveness of educating our patients in the importance of giving up smoking prior to elective foot surgery.


Surgeon Lieutenant Commander JJ Matthews SW Veitch MR Norton

Introduction: Femoroacetabular impingement (FAI) causes anterior hip pain, labral tears and damage to the articular cartilage leading to early osteoarthritis of the hip. Surgical hip dislocation and osteoplasty of the femoral neck and acetabular rim is a technique pioneered by the Bernese group for the treatment of FAI. We present and discuss our results of this technique.

Methods: Functional outcome was measured using the Oxford hip and McCarthy non-arthritic hip scores pre and post-operatively.

Results: Since January 2003, 36 hips in 34 patients (average age of 43 years (14–65)) underwent surgical hip dislocation for treatment of FAI. In 9 hips, grade 4 osteoarthritis was present in greater than 10 x 10mm regions after reshaping of the abnormal anatomy. In these cases, hip resurfacing was performed.

Of the 27 hips preserved, 14 had chondral ‘carpet’ flaps debrided, 17 underwent recession of the acetabular rim at the site of impingement, 6 had removal of medial osteophytes, 6 had labral and/or bony cysts excised and grafted and 1 underwent an osteochondral graft.

Oxford Hip Score improved from an average 36 (range 17–59) to 23 (12–45) and McCarthy hip score from 43 (9–74) to 62 (36–72) in the preserved hips at an average 15 months following surgery (range 6–33 months).

Discussion: The early results of surgical hip dislocation are encouraging. Careful patient selection is important in order to exclude patients with hip osteoarthritis. Long-term follow-up is required to see if this technique prevents the natural progression to osteoarthritis.


Mr T Wright Surg Lt Cdr D E Ayers A Clarke M Downs-Wheeler G Smith

Introduction: It is said that God gave us paired bilateral anatomical structures so that the trauma surgeon can compare the injured side with its uninjured counterpart. The axial rotational alignment of fingers, when disrupted by injury, may lead to scissoring. During examination, comparison is made between the rotational alignment of injured and uninjured fingers. This assumes that the rotational alignment of the fingers is symmetrical. A study was performed to ascertain normal rotational alignment, and establish whether this assumption is valid.

Materials and Methods: Standardised digital images were taken with fingers in extension. These were analysed using the angle-measuring tool on Adobe Photoshop software. The rotational angle used was that between a line joining the radial and ulnar borders of the nail plate, and the horizontal.

Results: Mean angles of rotation were 13° for the index finger, 10° for the middle, 5° for the ring and 12° for the little. Differences in the angle for ring and little fingers between the sides were not significant; these fingers are symmetrical. Index and middle fingers demonstrated statistically significant asymmetry of 2.6° (SD +/− 4.2°).

Discussion: Previous work has sought to quantify rotational alignment in cadavers or using wire markers and fluoroscopy. A new method, using digital photography and image analysis is described. We determined mean angles, showing symmetry of the ring and little but asymmetry of index and middle. Previous work has suggested that up to 10° of rotation can be tolerated. With only 2.6° of difference, clinical comparison of sides remains appropriate.


Colonel M P M Stewart Mr I Gill Mr S Graham

OBJECTIVE: To evaluate a peri-operative protocol developed to facilitate day case open shoulder procedures that historically have required overnight hospital admission.

METHODS: 75 consecutive day-case open shoulder procedures were performed in 75 patients (aged 18 – 65) followed up prospectively for a minimum of 6 months. The procedures included Open Primary Anterior Capsulo-Labral Reconstruction (ACLR) (24), open Revision ACLR (4), open Posterior Capsulo-Labral Reconstruction (1), mini-arthrotomy and rotator cuff repair (6), mini-arthrotomy and subacromial decompression (27), modified Weaver Dunn Reconstruction of Acromio-clavicular joint (ACJ) (2), decompression of ACJ (7), open release (Ozaki procedure) for frozen shoulder (1). Exclusion criteria included concomitant medical problems, and patients who would have no assistance in their care for the first 24 post operative hours. All patients received fast track general anaesthesia, peri-operative analgesia using intravenous Fentanyl, and Diclofenac (PR), and local Bupivicaine 0.5% to incisions and intra-articular spaces; patients were discharged with oral analgesics.

MAIN OUTCOME MEASURES: Patient satisfaction with overall experience, pain control, the incidence of nausea that was difficult to manage, the incidence of unplanned admission, attendance or delayed admission to hospital, postoperative complications.

RESULTS: 98% of patients were satisfied with their pain management. None of the patients suffered intractable post operative pain nausea or vomiting or required unplanned hospital admission or unexpected re-admission. All the patients were satisfied with their experience. There were no short or long term post operative complications.

CONCLUSION: The anaesthetic protocol and surgical techniques used in this study permitted same day discharge for a wide variety of open shoulder procedures. For selected patients, open shoulder surgery as a day case appears safe effective and acceptable to the patient.


Major S A Adams Mr I Brenkel

Introduction: The recent BOA blue book on blood conservation in elective orthopaedic surgery highlighted the need for blood saving strategies to be implemented. Perioperative management guidelines of oral anti-coagulation and anti-thrombosis medication have to date concentrated on warfarin use. Information and guidelines on aspirin usage in elective orthopaedics and its effects post operatively are limited.

Methods: Data was collected prospectively from 1936 patients who underwent 2024 primary unilateral total hip replacement in a single institution. All patients were treated with the same postoperative transfusion regime and thromboembolic prophylaxis. Preoperative medication, haemoglobin levels and patient demographics were recorded by a standard assessment. Post op transfusion requirements and haemoglobin levels were noted throughout the postoperative period.

Results: Multivariate analysis revealed that preoperative aspirin use was a significant independent predictor of postoperative transfusion requirement (p< 0.001).

Discussion: Expanding indications for the use of aspirin for primary and secondary cardiovascular disease prevention have meant that large numbers of our patients undergoing total hip replacement are concurrently taking the drug. With increasing and emerging evidence of the risks involved in blood transfusion, including vCJD transmission and immune related reactions coupled with reduced supplies of donor blood further measures to reduce transfusion requirement are needed. We recommend that in the absence of absolute contraindications to stopping aspirin therapy, it should be omitted for 1 week prior to total hip replacement.


Mr M. D. Brinsden Dr H. S. Gill Mr P. Reilly Prof. A. J. Carr Mr J. L. Rees

Background: Objective assessment of technical skill in orthopaedic surgery remains elusive. The general surgeons have validated a motion analysis model as a measurement of surgical ability for laparoscopic procedures. The aim of this study was to validate the motion analysis model in the context of simulated shoulder arthroscopy and use it to assess technical ability in a mixed population.

Methods: 35 volunteer subjects were recruited from the Oxford University Medical School and the Nuffield Orthopaedic Centre and stratified into groups according to their professional background. There were seven groups: consultant arthroscopic orthopaedic surgeons; senior orthopaedic SpRs (year 5/6); junior orthopaedic SpRs (year 1/2); basic surgical trainees; musculoskeletal physicians; graduate medical students; and hospital managers. Each subject completed a questionnaire to record previous arthroscopic experience and underwent psychometric testing. After receiving standardised instructions, each subject performed one diagnostic and one therapeutic procedure using the Alex Shoulder Professor (Sawbones Europe AB, Malmo, Sweden) model. The Patriot (Polhemus, Colchester, USA) electromagnetic tracking system was used to track hand movements during each procedure.

Results: We present the results of psychometric testing and motion analysis (time, distance and number of hand movements) data in subjects with a variety of experience of arthroscopic surgical techniques. We have demonstrated differences between the groups.

Conclusions: Objective assessment of arthroscopic surgical skills using motion analysis is valuable in identifying differing surgical abilities. We believe that this may help with the career development of trainees and in the development of specific teaching programmes for arthroscopic surgery.


Major WGP Eardley Mr PN Baker Major A Mountain

Background: The measurement facility on PACS is used to aid decision making. This facility is inaccurate and does not reflect clinical parameters, rendering its use ineffectual. Previous works utilised only a single prostheses type, were under-powered and not statistically robust.

Aim: To establish and statistically analyse the reliability of PACS software for the measurement of orthopaedic parameters at a university teaching hospital.

Methods: Retrospective analysis of radiographs of 100 patients (50 hip hemi-arthroplasty, 50 intra-medullary nailing) was performed to provide a wide base and allow a comparison of the spherical implant and a nail.

Implant sizing from theatre records was compared with the post-operative films. The size of the implant on radiograph, the magnification of the exposure and the effect of further magnification was noted. Analysis of the results was by paired student’s t testing incorporating inter-observer error into the test statistic.

Results: The hip prostheses were found to be oversized (range: 7–16mm; mean: 10.9mm). This is highly significant (p=< 0.01). The nails were similarly oversized (range: 0–6mm; mean: 1.87mm). This result was significant (p=< 0.05) although the error was less than for the spherical prosthesis. This is presumed due to the nature of the implant size and the distance of the implant from the cassette during exposure.

Discussion: This study demonstrates with statistical significance the unreliability of PACS measurement software. The manufacturer was contacted and has confirmed that accurate imaging can only be obtained on a named case, calibrated image. This has implications for all orthopaedic surgeons.


Major WGP Eardley Mr PN Baker

Introduction: Electrolyte imbalance in the elderly is a clinical problem faced by both elderly care physicians and orthopaedic surgeons alike. The abnormalities in homeostatic mechanisms that manifest with age can have dramatic consequences for the unwary clinician. This study aims to establish the incidence of hyponatraemia within an orthopaedic population and to determine whether this is different to a control group of elderly care patients.

Methods: Retrospective, consecutive analysis of serum sodium levels of 200 patients (100 hip fracture patients and a control group of 100 elderly care patients). Serum sodium levels on admission and during the inpatient stay were recorded and analysed using student’s t-tests to establish the incidence of hyponatraemia, changes in serum sodium level during admission and differences between the two groups.

Results: Hyponatraemia was evident in a third of all admissions (Orthopaedic: 29%; Elderly Care: 33%). The admission sodium level for both groups was not statistically different (t (198) =0.70, p=0.49). There was no significant difference in the observed hyponatraemia between the two populations throughout their care in hospital (t (198) =0.64, p=0.52).

Discussion: While there is a high incidence of hyponatraemia within the elderly population, there is no difference in its incidence between the aged orthopaedic population and the general elderly population. This is seen on admission and is also shown to be independent of operative procedures and fluid management as in-patients. Clinicians must be aware of the innocuous symptoms that may herald the catastrophic and avoidable consequences of this condition.


Surgeon Lieutenant Commander JJ Matthews A Llangovan Mr Norton

Introduction: The concept of osteoperiosteal decortication for the treatment of fracture non-union and mal-union was introduced by Judet in the early 1960’s. Over 1000 cases have been treated with a union rate of 80 – 90%.

Methods: A review of the clinical notes and plain radiographs was carried out on 21 patients who underwent osteoperiostal decortication between 2002 and 2004. There were 11 male and 9 female patients with 14 femoral, 5 tibial and 2 humeral fractures. 18 patients had non unions and 3 patients malunions. The mean time from fracture to surgery was 8.2 months for the non-unions (range 6 to 16 months) and patients had previously had a mean of 1.8 procedures (range 0 to 4) prior to the index decortication procedure.

Results: 19 patients progressed to union (90%). 9 patients had complications (43%). There were 6 failures of fixation requiring revision surgery and 4 deep infections (2 of which proceeded to amputation). In 4 patients supplementation of the decortication with bone graft or BMP was performed.

Discussion: This series represents the learning curve of the senior surgeon using this technique.

In the treatment of complex non-unions or malunions, the use of osteoperiosteal decortication can achieve a union rate of 90%. However there are high complication rates although the complications are usually salvageable. In this series the infection rate in the distal tibial was noted to be especially high with 3 out of the 4 infective complications being in the tibial fractures.


AP Wall AD Carrothers M Fehily

Literature searches are commonly performed by medical professionals when carrying out research and during study of a particular topic. Traditionally this was performed manually in a library using a system called index medicus, developed in the early years of the 20th century, and was an arduous task. Over recent years, this has commonly been performed online using electronic search engines, which has drastically reduced the difficulty and time involved in performing a thorough literature search.

Electronic versions of index medicus began in 1964 and were termed MEDLARS. Medline was developed soon after and for many years available on CD-ROM within libraries. In 1997, PUBMED became free to all online, incorporating Medline. (1) Use of online electronic search engines has increased enormously over recent years. In 1996 7 million searches were performed per annum, increasing to 400 million searches per annum in 2001. (1)

The researcher has the ability online to identify articles dating back to 1966, some 39 years of published research and articles to digest.

We performed a retrospective study of 100 medical professionals in a busy district general hospital in the UK with the purpose of identifying how retrospective many of the searches were.

Results showed only 29% of subjects researched papers more than 15 years old, with 65% of subjects only looking at papers 10 years old or younger.

Our study shows that many researchers are now ignoring articles beyond a certain age, and as a result much important research is being largely ignored and possibly repeated.


MP Newton Ede C Miller MHA Malik L Prudhoe RA Wilkes

Introduction: Ilizarov frames are widely used as an external fixation system. Whether applied for trauma, bone transport or deformity-correction they are usually applied for a minimum of three months and can be used for over a year. The psychological and lifestyle impact of frames has been shown to be significant.

Purpose: We examined the informational needs of patients with Ilizarov frames pre and post-operatively. We then assessed how these needs are met by the provision of a nurse-led support group.

Methods: All patients with Ilizarov frames applied at Hope Hospital, Manchester were contacted by postal questionnaire. Questions were asked about preparation before surgery, changes to lifestyle and information received. Specific questions were asked about attendance at the nurse-led Ilizarov support group.

Results: Thirty-seven patients replied. Twenty-two had frames on and fifteen had recently had them removed. Most patients reported feeling well prepared before surgery regarding the likely impact on their lives. Two-thirds (twenty-five) felt they had received adequate information. Three-quarters (twenty-six) patients had attended the Ilizarov support group and most (twenty-one) had attended the group pre¬operatively. Over three-quarters of patients agreed they would attend the group with a “frame problem” before attending their own GP. All patients found the group supportive and felt comfortable discussing their problems.

Conclusion: The Ilizarov Support Group is a useful resource for people with frames. The group atmosphere is supportive to patients and it is a valuable problem-solving environment. It helps patients prepare for their surgery and reduces attendance to primary care providers for frame related problems. We suggest other Ilizarov units may benefit from the provision of such a service.


A Abraham A Mountain TI Sherief SM Green S Roysam JL Sher

Background: The usefulness of the Nottingham Health Profile as a generic quality of health outcome measure has been described in a number of Orthopaedic conditions. This study was done to compare two quality of life questionnaires, the Nottingham Health Profile (NHP) and the Oswestry Disability Index (ODI) regarding the internal consistency, validity and responsiveness as outcome measures in patients undergoing surgery for lumbar nerve root decompression. We also assessed the effects of smoking, type of lesion, clinical presentation, number of levels involved, operating surgeon and duration of symptoms.

Methods: 37 patients with clinical nerve root entrapment, confirmed radiologically were treated with decompression surgery by two surgeons. We used the NHP and the ODI to assess the severity of symptoms prior to and at 3 and 8 months following surgery

Results: We were unable to detect factors predictive of better healthcare outcome scores after surgery for sciatica. There was a statistically significant improvement in the total ODI score and all NHP domain scores within the whole cohort, after treatment. NHP had a greater responsiveness in detecting improvement for pain and physical ability as measured by the effect size. Cronbach’s alpha for reliability of scores was consistently above the acceptable threshold of 0.90 for NHP scores and consistently below 0.90 for ODI scores. A “floor and ceiling” analysis revealed that the NHP consistently skewed scores at 3 months post op towards a better outcome compared to the ODI.

Conclusion: The generic Nottingham Health Profile appears to be a more sensitive health questionnaire than the Oswestry Disability Index in assessing the outcome of nerve root decompression surgery. We were unable to identify factors predictive of better outcomes using these scores as outcome measures.


Mr Cosker Mr Blagg Wong Turner Boppana Dr Nugent

Introduction: In 1996, Carley and Mackway-Jones examined British hospital readiness for a major incident. In the light of recent terrorist events in London, we revisited the issue and conducted a telephone survey of relevant parties to investigate whether the situation has changed almost 10 years on.

Material and methods: Middle grades in anaesthesia, accident and emergency medicine, general surgery, and trauma and orthopaedics were telephoned in trauma units across the UK and asked questions a proforma. Major incidents co-ordinators for each of the units were contacted, and their planning readiness, training oportunities, and recent rehearsals were assessed through a second proforma.

Results: A total of 179 middle grades were contacted in 34 different units throughout the UK, 144 responses were obtained. 47% had not read any of their hospitals major incident plans. Only 54% felt comfortable in the knowledge of their specific role in a major incident. Major incident co-ordinators were contacted at all 34 hospitals, and 50% responded. Rehearsal of major incident plans varied widely between hospitals with 82% of hospitals having practised within the last 5 years but only 35% planning for the next 12 months. Through real or rehearsed major incidents 95% of co-ordinators said errors were identified in their major incident plans. Limitations to improvement included: lack of funding, designated full time major incident planning co-ordinator, and lack of technology. There was no significant difference between units in London and those in other regions.

Discussion: Preparedness for major incidents in the UK remains poor despite 10 years since this was last assessed. Effective major incident plans require forethought, organisation, briefing of relevant staff and regular rehearsal.


Capt D Weller Mr M Ockendon Wng Cmdr K Trimble Mr S Hepple

We present the case of a 19-year-old woman who sustained a right talar neck fracture when the car in which she was travelling was involved in a high-speed collision. She was a front seat passenger travelling with her feet up on the dashboard, and was injured when the passenger airbag deployed. Front airbags are designed to provide protection from impact injury by having the occupant “fall” into the already-inflated device, and in order to inflate quickly enough they rely on an explosive exothermic reaction. It is postulated that an inflating airbag has similar properties to a blast wave produced by an explosion, and thus if a person is in direct contact with an inflating rather than inflated airbag, they may sustain high energy transfer injuries, not dissimilar to blast wave injuries. Although airbags have undoubtedly lead to safer motoring, it is well known that they can cause serious injury in normal usage, and injuries to the face, neck, chest and abdomen have been well documented. They should not be thought of as entirely benign devices.


Surg Lt Cdr S J Mercer Surg Lt Cdr D E Ayers

It is well recognised that there is a requirement for military surgeons to treat the victims of penetrating trauma while on operations. Casualty templates from recent and past conflicts demonstrate that a high proportion of survivable injuries affect the limbs; expertise in the management of penetrating trauma to the limbs is clearly important. While it is widely agreed that a combined specialities approach to limb injuries is necessary, debate has been ongoing for some time in the UK military as to the most appropriate means to gain the necessary experience for treating the wounds encountered on operations.

This study examines the operational requirement, looking at data and individual cases from Iraq, and considers the relevance of a training placement at The Johannesburg General Hospital, a level 1 trauma centre in South Africa.

Surgeon Lt Cdr Mercer RN is currently a Specialist Registrar in Vascular Surgery at MDHU Portsmouth and Surgeon Lt Cdr Ayers is a Specialist Registrar in Plastic Surgery at Frenchay Hospital in Bristol.


Mr A Abraham Major W Eardley Mr S Patil RJ Montgomery

Introduction: We studied the radiological and functional outcome in patients treated for complex femoral and tibial non unions with the Ilizarov method, specifically analysing the data for factors that may predict return to work.

Methods and Results: 78 patients were treated for femoral and tibial non-union at our institute between January 1992 and December 2003. Of these 40 patients (41 non-union) satisfied the criteria for complex non-union. 18 patients who were working at the time of injury failed to return to work and 7 had returned to work. 16 were not employed at the time of injury and were excluded from the analysis. Functional and radiological outcome was assessed using the Association for the Study and Application of Methods of Ilizarov (ASAMI) criteria. The minimum follow up was 18 months after removal of the frame.

Qualitative data for age, time to Ilizarov treatment, number of surgical procedures and time to union did not differ between the two groups (Student t-test). Those returning to work were more likely to have had a hypertrophic non union (p< .025) and were less likely to be using a walking aid (p< .05). No difference was seen between the groups with regards to segment involved, smoking, NSAID use, associated injuries, previous fixation, length of bone defect, free flap coverage, presence of infection, radiological and functional score.

Discussion: Our results suggest that return to work following Ilizarov treatment of a complex non-union does not correlate with either the biology of the fracture, the time course of treatment or the final result. We hypothesise that it is likely to be related to personality traits of the patients.


Captain N P McCullough Wing Commander G Pathak

Open phalangeal and metacarpal fractures of the hand were stabilised using an improvised external fixator. This was in the field hospital in Iraq and on military personnel evacuated to the UK. The fixator was improvised from K-wires and a syringe, both of which are readily available in the field hospital. It is a unilateral frame, sufficiently stable to maintain fracture reduction but not too rigid so as to allow micro-motion for fracture healing. We describe our method and recommend this simple method as a quick and easy form of initial or definitive fracture stabilisation in the hand. In the hostile environment of the field hospital we found this method simple, cost effective and relatively safe.


S Dharm-Datta J B King O Chan P J Buxton

Introduction: Symptomatic osteochondral lesions of the talus have been managed with a variety of operative techniques involving open or arthroscopic approaches to the ankle joint. The purpose of this study is to report our technique of drilling stable osteochondral lesions of the talus via a percutaneous retrograde approach using computed tomography for guidance.

Materials and Methods: Seven adult patients with Berndt and Harty Stage 2 or 2A/5 (subchondral cyst positive) talar osteochondral lesions, confirmed by magnetic resonance imaging, had retrograde drilling with CT guidance performed under local anaesthesia. Follow-up MR imaging was performed to investigate radiological evidence of healing.

Results: All retrograde drillings performed were technically successful.

Discussion: The concept of retrograde drilling is to preserve intact articular cartilage while encouraging revascularisation of the osteochondral fragment. The use of CT allowed drilling without conventional direct visualisation of the articular surface via arthrotomy or arthroscopy. The procedure can therefore potentially be performed in an outpatient setting. Suggestions are made from review of the literature as to improve further the technique for future studies.


T Kane JDF Calder

Introduction: A recent clinical study has suggested that topical GTN may improve the outcome of non-insertional Achilles tendinopathy. The mechanism for this improvement is obscure but is thought to be due to modulation of local nitric oxide (NO) levels. The purpose of this study was to assess the clinical and histological results of topical GTN for non-insertional Achilles tendonitis.

Methods: 40 patients with non-insertional Achilles tendonitis underwent standard non¬operative therapy. 20 patients also used topical GTN daily. AOFAS, AOS visual analogue scores and SF36 forms were completed pre-treatment and 3 months later. Patients who failed conservative treatment and underwent surgery had histological examination of the Achilles tendon and histochemical analysis for isomers of NOS (eNOS and iNOS) as a marker of NO production.

Results: There was an overall improvement in symptoms in both groups but no significant difference in the improvement between them – there was no additional benefit in using GTN patches. 4 patients also had to stop using patches within 3 weeks because of headaches.

Histological examination did not show any difference in collagen synthesis or remodelling between the 2 groups and there was no evidence of stimulated wound fibroblasts in the GTN group. There was no difference between the groups in the expression of eNOS or iNOS.

Conclusion: This study fails to demonstrate any improvement in symptoms when using GTN patches. There is no histological evidence that GTN promotes degenerate tendon to stimulate wound fibroblasts and increase collagen synthesis and remodelling. GTN patches do not appear to modulate the expression of NOS enzymes in diseased Achilles tendon. The use of GTN patches in the treatment of non-insertional Achilles tendonitis remains questionable and the role of NO as a mediator of inflammatory response remains elusive.


F. Qureshi K. Draviaraj D. Stanley

Between 1993 and 1996, 35 Kudo unlinked total elbow replacements were performed in a consecutive series of 33 rheumatoid patients. All patients had radiological changes of Larsen grade IV or grade V and met the diagnostic criteria of the American Rheumatism Association. The indication for surgery was intractable pain leading to loss of function. There were 6 men and 27 women with a mean age of 60 years (37 to 79) at the time of surgery. A total of 23 patients were reviewed at a mean follow up of 12 years (10 to 13). Ten patients (11 replacements) had died from unrelated causes prior to the review period. Function was assessed with regards to activities of daily living with the Mayo Clinic Performance Index and DASH scoring. Seven patients had undergone revision surgery after the index procedure with conversion of the Kudo replacement to a Coonrad-Morrey prosthesis. The mean time to revision was 6 years (1 to 11). The indications for revision were periprosthetic fracture (n=1), infection (n=2) and aseptic loosening (n=5). This review represents the longest follow up of the Kudo implant outside of the design unit and includes a detailed assessment of the failed arthroplasties.


BV. Somanchi L. Funk

Previous studies have demonstrated the benefits of arthroscopic arthrolysis in relieving pain and improving motion in arthritic elbows, but none have reported the specific functional recovery. This study aims to review the functional outcome and patient satisfaction in a series of patients who underwent arthroscopic elbow arthrolysis for intrinsic stiffness, pain and arthritis not suitable for arthroplasty. Twenty six patients who underwent arthroscopic arthrolysis over a three year period were included. All patients were manual workers or strength athletes. All had pain and stiffness secondary to primary or secondary arthritis, with or without loose bodies. Pre- and post-operative evaluation included the Elbow Functional Assessment score, patient satisfaction and return to work and sports. The mean follow up period was 22 months. Function improved significantly in 87% with overall improvement in the Elbow Functional Assessment score from a preoperative score of 48 to a postoperative score of 84 (p< 0.05). All except three patients returned to their desired level of activity by 3 months postoperatively. Pain improved in 91%, mechanical symptoms in 80%, stiffness in all except one. The arc of elbow movement improved from 106° to 124° with a mean gain in elbow extension of 13°. Mayo elbow performance index also significantly improved postoperatively. Overall, 87% patients were very satisfied with the outcome. We conclude that the arthroscopic arthrolysis improves elbow function and returns patients to their desired level of activity, as well as improving range of motion and pain in patients with intrinsic elbow stiffness and pain.


M. Adeeb I. Mersich L. Neumann M. Thomas

Background: Total elbow prostheses are broadly classified into linked and the unlinked categories. We have looked at long-term results of unlinked Kudo 5 total elbow replacement used in the treatment of patients with rheumatoid arthritis in 2 hospitals.

Methods: 87 Kudo 5 Total elbow replacements in 70 patients with adult rheumatoid arthritis were performed at Wexham Park Hospital, Slough and City Hospital, Nottingham by 2 specialist elbow surgeons, the senior authors. 16 patients had died and 8 patients were lost to follow up. 62 elbow replacements in 46 patients were evaluated at a mean follow up of 79 months [29–137 months] using the Mayo Clinic Performance Index. Postoperative radiographs were also reviewed for loosening using standard anteroposterior and lateral films

Results: Preoperatively 6 had moderate pain and 56 had severe pain. Postoperatively the pain was rated as none or mild by 58 and moderate by 4. The average Mayo Elbow Score improved from 37 preoperatively to 86 postoperatively. The mean arc of flexion/extension improved from 60 to 99 degrees. There were 14 complications including ulnar neuropraxia, fracture, dislocation, triceps rupture and loosening. 4 cases were revised, 2 for aseptic and 2 for septic loosening. Postoperative radiographs showed 5 cases with loosening around the ulna component.

Conclusions: The long-term results using the Kudo 5 elbow prosthesis in patients with rheumatoid arthritis are acceptable and comparable to other series reported of this implant. To date this is the largest series reported with the longest follow up using this implant.


M. Adeeb N. Raza M. Thomas

To date there has been only one published series of elbow arthroplasty in patients with Juvenile Idiopathic arthritis. These patients pose particular problems because of the size and variable shape of the humerus and ulna together with the soft tissue contractures and bony erosion which can sometimes be severe. We have reviewed the results of elbow arthroplasty using the unlinked Kudo 5 and the linked Coonrad-Morrey implants which in our practice have different indications dependent upon bone stock and stability.

Methods 19 total elbow replacements in 13 patients with juvenile idiopathic arthritis were performed by 1 specialist elbow surgeon, the senior author. 13 of these are Kudo 5 and 6 are Coonrad-Morrey implants. The mean age at operation was 39 years. 6 of the elbow replacements had undergone previous surgery, 4 had an interposition arthroplasty and 2 a synovectomy and radial head excision. No patients were lost to follow up. All were evaluated at a mean follow up of 49 months [6–84 months] using the Mayo Clinic Performance Index. Postoperative radiographs were also reviewed for loosening using standard anteroposterior and lateral films.

Results Preoperatively 7 had moderate pain and 12 had severe pain. Postoperatively the pain was rated as none by 13 and mild by 6. The average Mayo Elbow Score improved from 26 preoperatively to 81 postoperatively. The mean arc of flexion/extension improved from 85 to 108 degrees.12 elbow replacements had intra and post-operative complications and 2 elbows have been revised.

Conclusions The medium-term results of Total Elbow Replacements in patients with Juvenile Chronic Arthritis are acceptable and comparable to the only other published series which also records a high complication rate.


A.M. Ashmore C. Gozzard N. Blewitt

Aims: To review the results from a series of GSB III total elbow arthroplasties performed at an independent centre. Between 1996 and 2004 the senior author performed 58 total elbow arthroplasties in 44 patients (10 males, 34 females) using the GSB III implant. These were reviewed and the outcome assessed through the use of a patient-answered questionnaire and clinical and radiological review. Mean age was 65 (49 to 84 years). Indications for surgery included rheumatoid arthritis (46 elbows) and post-traumatic osteoarthritis (11 elbows). Mean F/up was 4.1 years (0.8 to 8.5 years). 4 patients had died (6 elbows) and 4 patients (4 elbows) were unavailable for review. 2 of the implants had been revised (1x aseptic loosening, 1x deep infection), leaving a total of 46 elbows available for review. The survival rate at a mean of 4 years was 98% with aseptic loosening as the endpoint. Complications included 1 case of intraoperative fracture and 1 persistent ulnar neuritis. Overall patient satisfaction was high. The mean Mayo Elbow Performance Score was 83 out of 100 (range, 34 to 100) and mean Liverpool Elbow Score was 8 out of 10 (range, 1 to 10).

Conclusion: Previous studies of outcome following total elbow arthroplasty using the GSB III elbow prosthesis at independent centres have shown satisfactory results, but have looked at small groups of patients. Our results offer more robust data to show that the medium term outcome following total elbow arthroplasty using the GSB III prosthesis is satisfactory.


Manish Changulani Prof U.K Jain

The aim of this study was to compare the results of humerus intramedullary nail(IMN) and dynamic compression plate(DCP) for the management of diaphyseal fractures of humerus.

Material & Methods: 47 patients with diaphyseal fracture of shaft humerus were randomised prospectively and treated by open reduction and internal fixation with IMN or DCP. The criteria for inclusion was Grade 1,2a compound fractures Polytrauma Early failure of conservative treatment Unstable fracture. The patient with pathological fracture, Grade 3 open fracture, refracture, old neglected fracture of humerus were excluded from the study. 23 patients underwent internal fixation by IMN and 24 by DCP. Reamed antegrade nailing was done in all cases. DCP was done through an anterolateral or posterior approach.

Results: The outcome was assessed in terms of functional outcome and the incidence of complications. Functional outcome was assessed using the Americans Shoulder and Elbow Surgeons Score (ASES).On comparing the results, there was no significant difference in ASES score between the two groups. The rate of complications was found to be higher in patients treated with IMN(p< .05). The complications that were encountered with IMN were non union, shortening of the arm,impingement of the shoulder, implant failure. The rate of secondary surgery was also found to be significantly higher with IMN(p< .05)

Conclusion: There is sufficient evidence to suggest that DCP still remains to be the operative treatment of choice for diaphyseal fractures of humerus as use of IMN is associated with long learning curve, technical difficulties and higher complication rate. IMN may be indicated in specific situations like segmental fractures,pathological fratures though this study did not aim to look into that aspect.


R. Bryant M. Dennison S. Royston S. Kapoor

To review indications and outcomes of all Ilizarov arm fixators applied by the two limb reconstruction surgeons. All patients treated with an upper limb Ilizarov frame were identified. Casenotes were reviewed. Demographic data, indications and duration of frames collected. Forty-seven patients had application of an arm frame. Average age 43 (17–81). Tertiary referrals in 72%. Previous surgery in 79%. Mechanism of injury included: 37% RTA, 40% simple falls. Reasons for frame usually multifactorial. Half of fixators applied acutely (< 6 weeks), 17 for non-unions. Two patients had neurological complications from frame surgery. One radial palsy possibly from humeral plate removal. One median palsy due to pressure from wire. Average frame time was 152 days (34–343). Over 80% achieved expected outcome -obtaining good function or fracture union. One patient had an above elbow amputation for persistent infection. Fourteen needed further frame surgery including 5 for frame removal, 3 adjustments and 2 corticotomies for lengthening. Most frames removed in clinic. The Ilizarov technique appears well tolerated and successful despite often infected or deformed tissues. Indications and intended function of arm frames very varied. This technique allows stabilisation (with/without bone loss), treatment of non-unions and lengthening/ bone transport. The Ilizarov technique is valuable for limb salvage/ reconstruction.


E. Robinson P. Douglas J. Orr J. Pooley

Purpose of the study: to demonstrate a mechanism of loosening of the Souter-Strathclyde Total Elbow Replacement (TER) using evidence from revision surgery.

Methods: nine Souter-Strathclyde humeral and ulnar components retrieved from revision surgery for aseptic loosening were examined macroscopically and then microscopically under low power magnification. The wear patterns were compared and photographed.

Results and conclusion: inspection of the retrieved cobalt chrome steel humeral components revealed no evidence of surface wear. However on examination of the polyethylene ulnar components six of the nine exhibited macroscopic wear taking the form of deep linear grooves on either the medial or lateral articulating surface. Microscopic examination revealed wear exhibited as complete disruption of the polyethylene machining lines on the medial and lateral articular surfaces, but almost complete preservation on the central gliding ridge. The findings are best explained in the context of normal elbow kinematics and congruence of the Souter-Strathclyde components. The normal elbow joint is not a simple hinge joint. In addition to flexion/extension, axial rotation and abduction/adduction motion patterns occur. However articulating surfaces of the Souter-Strathclyde components are highly congruent and thus resist the elbow’s normal translational and rotational movements. Our wear patterns are the result of humeral component rocking during flexion and extension as a result of this resistance. The central gliding ridge is preserved because the humeral component is not always in contact with it as it rocks out of its articulation in the coronal plane. Furthermore as the humeral component rocks, the sharp edge of its articulating surface makes contact with the articulating surface of the ulna causing abrasion and in the extreme circumstance the deep linear grooves observed. The biomechanics eventually lead to component loosening.


Z. C. J. Higgs B. Danks M. Sibinski L.A. Rymaszewski

Over the last 15 years there have been a series of publications reporting the beneficial effects of elbow arthrolysis, with considerable variation in operative technique and post-operative management.

Aim. To assess the results of open elbow arthrolysis in patients who did not receive any physiotherapy after discharge from hospital, although this is routinely prescribed by many surgeons.

Patients and Methods. Prospectively collected data of 34 patients with a minimum follow-up of 1 year after arthrolysis was analysed. All the procedures were performed by the same surgeon, achieving as much improvement in elbow motion as possible at operation. All the patients had continuous brachial plexus blocks and continual passive motion for 2–3 days postoperatively but none received any physiotherapy after discharge. At review, a senior physiotherapist formally assessed all the patients, including measuring elbow motion with a goniometer.

Results. All patients’ arc of movement improved from, with mean elbow flexion increasing by 16 degrees and extension 20 degress at the last follow-up. Upper limb function, assessed with a Disabilities of the Arm, Shoulder and Hand score (DASH), had improved 30%. Pain had decreased from 4.8 to 3.1 using the Visual Analogue Score. The greatest improvement in motion was obtained in the stiffest elbows – 5 patients with an arc of 30 degrees or less pre-operatively achieved an arc of 96 degrees by the time of the last review. Only early complications occurred – ulnar neuritis and significant pain – but these symptoms had largely settled by the time of the last review.

Conclusions. Good results of open arthrolysis for post-traumatic elbow stiffness can be achieved with continuous brachial plexus blocks and continual passive motion for 2–3 days post-operatively. There appears to be little evidence to support formal treatment with physiotherapy after discharge from hospital, as our results are similar to other reported series.


SCAPULOTHORACIC FUSION Pages 349 - 349
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TS Waters AM Noorani AA Malone Bayley JIL SM Lambert

We report our results and technique of scapulothoracic fusion. 14 fusions were performed in 10 patients between 2001 and 2005. The underlying diagnosis was fascioscapulohumeral dystrophy in 7 patients (11 cases). The diagnosis in the remaining three patients was failure of scapular suspension due to C4/5 tetraplegia, stroke and cerebral palsy. There were five women and five men with an average age of 35.4 years (range 15–75) In each case the medial scapular border was wired to the ribs with the support of a one-third semi-tubular plate and autologous bone graft. We compared pre and post-operative active forward flexion and abduction. Satisfaction with the procedure was also rated. There was no need for single-lung ventilation or a chest drain and there were no significant post-operative complications. There were two cases of non-union. One patient, a heavy smoker, travelled abroad and has been lost to follow-up, the other aged 76 is awaiting revision surgery. The mean range of preoperative active forward flexion and abduction were 71° (range 30–90°) and 58° (range 40–90°) respectively. The mean post-operative values were 96° (90–120°) and 94° (80–120°) respectively. The remaining 8 patients were enthusiastic or satisfied with the result of the operation. This technique was very successful in 12 out of our 14 cases (85.7%) and is to be recommended. However, union may be unpredictable in older patients


Dr. S. Mehta Dr. A. Sud Dr S. K. Kapoor

To evaluate the results of open reduction in unreduced posterior dislocation of the elbow, done irrespective of the time since injury or age of the patient. Ten such cases in which the dislocation had been unreduced for more than 3 weeks since injury were included. Stiffness of the elbow was the main indication for the operation. Average age of the patient was 34.3 years (range 13 years to 65 years). Average time since injury was 3.9 months (range 2 month to 6 months). 3 patients had associated fractures around the elbow joint. All the patients had non functional elbow motion to perform any activity of daily living. We used speed’s procedure in all cases. At an average follow up of 18.5 months (range from 11 to 28 months), 8 patients achieved functional range of motion for activities of daily living and maintained an average arc of flexion(median) of 100 degrees and an average supination – pronation arc of 139.5 degrees. According to the Mayo Elbow Performance Index 5 patients achieved excellent results, 3 achieved good results and 2 achieved poor results. Complications included 2 cases of pin site infection, 1 case of ulnar neuritis and 1 case of delayed wound healing. We conclude that open reduction can provide painless, stable and functional elbow even in cases which are unreduced up to 6 months after the original injury.


K.A.Z. Sivardeen M. Green S.N.F. Massoud D.J.A. Learmonth

Background – Frozen Shoulder is a common condition which causes significant morbidity in people of working age. The 2 most popular forms of surgical treatment for this condition are Manipulation under Anaesthesia (MUA) or MUA plus Arthroscopic Capsular Release (ACR). Both treatment modalities are known to give good results, but no-one has compared the 2 to see which is better.

Aim – To compare the outcome in patients with primary frozen shoulder, who are treated by either MUA or MUA plus ACR.

Method – 61 patients with primary frozen shoulder were treated by either MUA or MUA plus ACR. Each patient had their American Shoulder and Elbow Score (ASES), and their Oxford Shoulder Score (OSS) measured pre and post-operatively.

Results – The patients who had MUA plus ACR had a mean ASES of 24.8 preoperatively, 64 at 4 months, and a mean of 75.4 at 12 months. The mean OSS was 32.5 pre-operatively, 48.5 at 4 months and 53.4 at 12months. The patients who had a MUA had a mean ASES of 28.7 pre-operatively, 60.9 at 4months and 69.6 at 12months. The mean OSS was 33 preoperatively, 46.5 at 4 months and 50.9 at 12 months.

Conclusions – Both treatments give good results. MUA plus ACR give superior numerical results at 6 to 12 months post-operatively, however, these figures did not reach statistical significance


A.A. Malone A. Jaggi S.M. Lambert J.I.L. Bayley

This study identifies variations in presentation and demographics for different forms of shoulder instability. We analysed 1020 unstable shoulders (855 patients) from a previously presented database. Demographic details, direction and aetiology were obtained from medical records. Anterior dislocations comprised 67%, posterior 31% and inferior 2% of all directions of instability and 75 shoulders had multidirectional instability. Structural causes were dominant in anterior instability (traumatic 39% and atraumatic 38%) and muscle patterning in posterior (81%) and inferior (90%) instability. Males accounted for 64% of all patients (73% of all structural patients and 53% of muscle patterning patients. Mean age at presentation was 25 years old (structural patients 28 years and muscle patterning patients 21 years old). There were 690 unilaterally unstable shoulders (57% right- and 43% left-sided); the dominant arm was affected in 58% overall, in 42% of all left-handers and only 33% of left-handers with muscle patterning. Bilateral shoulder instability occurred in 19% of all patients (12% of patients with structural instability and 28% of those with muscle patterning instability). For muscle patterning, the mean age at onset of symptoms was 14 years, and mean length of symptoms before presentation was 8 years. There was a trimodal distribution of age at onset of symptoms corresponding to peaks at 6, 14 and 20 years. In the group with onset of muscle patterning under 10 years old, there was a higher proportion of females (71% vs 47%), laxity (63% vs 29%) and bilaterality (54% vs 42%), and fewer presenting with pain (17% vs 50%). As age at presentation increased, pain increased and joint laxity decreased. Bilaterality did not appear to be associated with gender, the presence of laxity or pain. Muscle patterning instability is associated with a demographic and presentation profile which may help distinguish it from structural forms of instability.


A.A. Malone A. Noorani A. Jaggi S.M. Lambert J. Cowan J.I.L. Bayley

We present the use of dynamic electromyographic analysis (DEMG) in the diagnosis of muscle patterning instability. DEMG’s were requested in 168 of 562 muscle patterning shoulders with suspected subclinical or clinically complex muscle patterning instability. An experienced neurophysiologist (blinded to the clinical findings and direction of instability) inserted dual-wire tungsten electrodes into pectoralis major, latissimus dorsi, infraspinatus and anterior deltoid. Muscle activity was recorded during rest, flexion, abduction, extension, and cross-body adduction. 5 investigations were abandoned. The timing and magnitude of muscle activity was noted and compared to the clinical diagnosis and direction of instability. DEMG identified a total of 204 abnormal muscle patterns in 163 shoulders. The examination was normal in 13 patients (8%). A single muscle was abnormal in 63 shoulders, 2 muscles in 55, 3 muscles in 9, and all 4 muscles in one shoulder. Over-activation of pectoralis major was identified in 58%, and latissimus dorsi in 70%, of shoulders with anterior instability. In posterior instability, latissimus dorsi was overactive in 76%, anterior deltoid in 14% and infraspinatus was under-active in 24%. Pectoralis major and Latissimus dorsi were both overactive in 38% of anterior, 29% of posterior and 38% of multidirectional instability. Abnormal muscle patterns were identified in 52 shoulders with subclinical muscle patterning. A further 98 shoulders had 134 clinically abnormal muscle patterns. These were confirmed by DEMG in 57 cases (sensitivity 43%), and DEMG’s were normal in 77 (specificity 43%). DEMG also identified 65 additional muscles as abnormal in the 98 clinically abnormal shoulders. DEMG performed by an experienced neurophysiologist provides additional information regarding abnormal muscle activation in selected complex or subtle cases of muscle patterning instability in which clinical examination has a low sensitivity and specificity.


R. Parmar P. Wykes E. Burgess AC. Fisher PJ. Hughes

The study objective was to assess if the mechanical properties of Polylactic Acid (PLA) bio-absorbable suture anchors vary with temperature? Bio-absorbable suture anchors may offer advantages over metal anchors. However, their performance at body temperature has been questioned in recent literature (Meyer et al). In particular, constant tension at body temperature caused early failure at the anchor eyelet. Using a previously validated mechanical jig, 15 standard locked sliding arthroscopic knots (Duncan Loop + three alternate hitches) were tied by the senior author using PAN-ALOK anchors (DEPUY MITEK, Edinburgh, UK) and ETHIBOND sutures (ETHICON) and placed under a standard constant tensile load reproducing the action of the surgically repaired rotator cuff. All anchors were loaded for at least five days to match previous studies. Eight were incubated at a constant 37°C and six were kept at room temperature. The elongation of the suture knot/anchor construct was assessed by a rheostat within the mechanical jig. Sample unused, room temperature and body temperature anchors were blindly analysed using plane polarized light microscopy with a graticule to assess deformation, concentrating on the eyelet region. Mean elongation of body temperature anchors = 0.461mm (0.159 – 0.952) Mean elongation of room temperature anchors = 0.278mm (0.159 – 0.793) Unpaired t-test: p=0.24 Microscopic analysis of the anchor material showed no difference in structural deformation in the three anchors. Our model suggests no significant increase in elongation at body temperature for this commonly used arthroscopic suture anchor / knot construct. This counters previous work. It gives us confidence to continue to use such devices.


D. Nuttall J.F. Haines I.A. Trail

To compare the effect of standard non-offset and offset humeral heads on early glenoid loosening. From 2002–2004 in a prospective study, 12 patients with osteoarthritis and intact rotator cuff had a TSR with an offset humeral head matching normal anatomy. Five tantalum markers were introduced into the scapula and acromion, spaced widely apart; four markers were placed in a pegged glenoid component. RSA radiographs were taken postoperatively, three, six, twelve months. The micromotion of this offset head group was compared with a baseline series of TSRs with standard non offset humeral head implants which had previously been measured over 24 months. At 24 months, the largest segment translation for the offset head group was in the anterior/posterior direction with a mean of 0.24mm, the standard head group mean was 0.61mm, t=1.3,P=0.21. Proximal/distal translation gave means of 0.51mm (standard head) and 0.17mm (offset head), t=1.3,P=0.21. Medial/lateral translation was smallest for the offset group with mean 0.16mm this is less than half the standard group mean 0.57mm and is significant, t=1.4,P=0.19. The largest rotation was anteversion/retroversion with a mean of 1.50 (offset) compared to 4.40 (standard), t=2.3, P=0.04. Varus/valgus tilt differed significantly with means 0.90 (offset) and 2.50 (standard), t=3.8,P=0.001; and finally anterior/posterior tilt had smallest means of 0.70 (offset) and 1.00 (standard), t=1.2,P=0.25. Maximum total point motion was also significantly different at 24 months, means of 0.66mm (offset) compared to 1.65mm (standard), t=2.3,P=0.04. Early migration occurs in both groups of pegged components. A principal component micromotion index illustrates the complexity of micromotion. Offset heads move significantly less than the standard type, the significant differences in MTPM movement and in rotation (varus/valgus tilt) suggest that the offset head may decrease eccentric loading


I. Bashir M.E. Bone J.J. Haynes A.L. Armstrong

The study investigated if suprascapular nerve(SSN) rhizolysis could give effective and longlasting pain relief to patients with chronic shoulder pain(massive cuff tears and /or osteoarthritis) some with significant comorbidity, who did not wish for or were unable to withstand surgery. Sixty two patients(12 male, 50 female, mean age 74years) with longstanding moderate to severe shoulder joint pain(massive rotator cuff tears, osteoarthritis, rheumatoid arthritis), who had failed conventional non-operative management and who were unsuitable for further shoulder surgery, were assessed for radiofrequency(RF) rhizolysis to the SSN. Most patients reported significant anaesthetic co-morbidity. All patients had received full orthopaedic or rheumatological assessment with investigations including Xray, ultrasound and MRI scan. Ninety-five percent of patients had undergone a SSN block which had afforded > 50% pain reduction for three to six months. The suprascapular notch was identified with Xray control. The SSN was located with 100 Hz and 2 Hz stimulation of an insulated 50mm needle. Once localised, 5 mls of 2% lignocaine was injected and a radiofrequency thermocoagulation lesion undertaken at 700C for 90 seconds. Eighty-five percent of patients reported> 50% pain relief still present at six months (as reported by VAS score). No serious adverse side effects were reported (pneumothoraces, haematomas, infection, neurological deficits). RF rhizolysis of the SSN may be a useful treatment for the group of patients with chronic shoulder pain for whom surgery is not an option.


C. Hand P. Rosell H. Gill A. Carr J. Rees

The aim of this study was to use motion analysis to study a surgeon’s learning curve for an arthroscopic Bankart repair on a training model in a skills laboratory. Six fellowship trained lower limb surgeons unfamiliar with advanced shoulder arthroscopy performed an arthroscopic Bankart repair on an ALEX shoulder model. Standardised training was given and then an electromagnetic tracking system used to objectively assess hand movements, distance travelled by hands and time taken while the surgeons performed the technique. The arthroscopic repair was repeated three times on four consecutive occasions by each surgeon giving a total of 72 repair episodes. Analysis revealed improvement of all outcome parameters with less hand movements, less distance travelled and less time to complete the task. This study objectively demonstrates a learning curve for arthroscopic Bankart suture in a skills laboratory. It indicates the potential benefits of practicing aspects of arthroscopic techniques in a skills centre on appropriately selected models.


A.A. Smit I.A. Trail J.F. Haines R. Conlon

Although few published papers assess the results of revision total shoulder replacement for painful hemi-arthroplasty with a functional rotator cuff, surgical outcome is accepted as being poor. Our experience suggests that results are poor if a well-fixed humeral stem is revised to correct version, and if a non-functional rotator cuff is not alternatively managed. We identified fifteen patients with painful hemi-arthroplasty and a suspected functional rotator cuff that underwent revision total shoulder replacement at Wrightington hospital over a ten year period. The aetiology comprised osteoarthritis (seven), inflammatory arthritis (five), trauma (two) and avascular necrosis (one). The average time interval to revision surgery was 44.5 months. Humeral head size was up-sized in two and down-sized in seven cases at revision surgery. Three cases underwent iliac crest autografting for glenoid deficiency. Four cases underwent humeral stem revision for incorrect version. The average surgical time for primary total shoulder replacement at Wrightington hospital is 80 minutes while the average time for these revision total shoulder replacements was 105 minutes. Four patients had an unsatisfactory outcome according to Neer’s criteria due to an intra-operative greater tuberosity fracture (one), an intra-operative humeral shaft fracture (one) and a non-functional rotator cuff (two), one of which was revised to an extended head prosthesis with good outcome. Surgical time for revision and primary total shoulder replacement did not differ significantly if humeral stem revision or glenoid augmentation was not indicated. Oversized humeral head components may cause pain due to overstuffing the joint and soft tissues. Revision total shoulder replacement for hemi-arthroplasty with incorrect prosthetic version cannot guarantee an improved outcome. Significant glenoid deficiencies can be effectively managed by iliac crest bone grafting at revision total shoulder replacement. Rotator cuff deficient patients should be managed with alternative prostheses.


MR Webb T Even D Raj R Abrahams SA Copeland O Levy

Introduction Pridie and Steadman independently noticed the development of a smooth layer of fibrocartilage when treating exposed subchondral bone in the knee using their techniques of drilling or microfracture respectively. Since 1997, patients presenting to our unit for a Copeland cementless Surface Replacement Arthroplasty (CSRA) with a congruent glenohumeral joint have routinely undergone biological resurfacing of the glenoid using a technique similar to that described by Pridie and Steadman. We present this technique of glenoid resurfacing, the histological and surgical outcomes in a consecutive group of patients.

Methods/Results Between 1987 and 2002, 218 CSRA were performed without replacing the glenoid. From 1997, 133 CSRA have been performed with multiple drilling of the glenoid face with a guide wire through the subchondral bone in to the underlying soft cancellous bone to stimulate bleeding. This causes formation of a fibrocartilaginous layer – biological resurfacing. 9 (6.8%) of the patients with biological resurfacing have subsequently undergone a shoulder arthroscopy for postoperative impingement pain. This allowed us to evaluate the glenoid surface – macroscopically a layer of cartilage was noted in all patients, intraoperative biopsies have confirmed this layer to be fibrocartilage microscopically. In the biological resurfacing group, the mean postoperative Constant score (CS) is 86.9 (age/sex adjusted), with a mean improvement in CS of 71.0. 3 (2.3%) patients have required revision.

Conclusion Our results confirm that glenoid drilling at the time of CSRA leads to the formation of a fibro-cartilaginous layer over the glenoid, with significant improvements in Constant scores and functional outcomes. These results are comparable to other published results for total shoulder replacement with polyethylene resurfacing of the glenoid and better than patients that have undergone stemmed shoulder hemiarthroplasty.


D Buchanan M Jeyam Lars Neumann W Angus Wallace

The NHS Plan (2000) identified the need for change in the way patients are asked to give consent for surgery to make the process more explicit. A new NHS operation consent form was introduced in April 2002 following the Bristol enquiry into deaths associated with Cardiac Surgery.

Methods: We have addressed the obtaining of consent for surgery as an evidence-based exercise. The published literature has been reviewed and we have attempted to accurately quantify the success rates for surgery, complication rates and poor outcomes in order to identify what the likely benefits and risks are for our common operations –

Shoulder – Arthroscopic Sub-Acromial Decompression, Anterior stabilisation, Rotator Cuff repair, excision lateral end of clavicle and Shoulder Arthroplasty.

Elbow – Tennis elbow release, Arthroscopic Debridement, OK Operation and Elbow Replacement We became increasingly aware throughout this exercise that although there were many papers published; collating the relevant evidence based information for patients was either difficult or impossible.

Evidence was therefore been categorised into 4 levels:

National & International published results

Our own results, either published or presented at scientific meetings

Our own results as identified in internal audited outcome studies – unpublished

Our opinion of the risks or benefits unsupported by any scientific or published evidence.

Results: We have taken the standard NHS Consent Form and modified it in a printed format to present to the patient a clearer description of the anticipated outcome from their surgery (with percentages). This evidence based consent form was evaluated in a combined prospective and retrospective survey of 60 patients who attended our pre-operative assessment clinic. We will present the results of the survey and demonstrate the standardised Consent Forms.

Conclusions: The majority of the information the patient wished to know was Level 4 evidence!


A.L. Armstrong J.J. Dias

This study describes the method and results of a new way of stabilising painful unstable sternoclavicular joints using the sternocleidomastoid tendon. Painful instability of the sternoclavicular joint is a rare condition whose cause is either of spontaneous onset in young principally females with generalised joint laxity or of traumatic onset. The direction of instability can be anterior, superior or posterior. Surgical stabilisation is difficult and has principally consisted of using periosteum or subclavius and reefing the joint to the first rib with its attendant risks and variable results. We describe eight cases of painful sternoclavicular joint instability treated by using the sternocleidomastoid tendon and passing it through the medial clavicle and onto the manubrium of the sternum to stabilise the joint. This method of treatment is simpler, is reproducible and avoids the potential risks of reefing the joint to the first rib. There is no decrease in function of the sternocleidomastoid muscle from this procedure. All directions of instability can be treated using this tendon by varying the position of the bone hole. The results show comparable outcome for stability with other studies. We conclude that using the sternocleidomastoid tendon to stabilise the sternoclavicular joint is a simpler and safer method of treating these injuries and gives comparable results to the other methods of surgical stabilisation.


C K Tan I Guisasola B Machani G Kemp C Sinopidis P Brownson S Frostick

Purpose: The aim of this study was to evaluate prospectively the outcome following arthroscopic Bankart repair using two types of suture anchors, absorbable and non-absorbable.

Method: Patients with a diagnosis of recurrent traumatic anterior instability of the shoulder, seen between April 2000 and June 2003, in a single unit were considered for inclusion in the study. Patients were assessed preoperatively and postoperatively using a subjective patient related outcome measurement tool (Oxford instability score), a visual analogue scale for pain and instability (VAS Pain and VAS instability) and a quality of life questionnaire (SF-12). Length of follow up was 1.5 to 5 years, mean 2.6 years. The incidence of recurrent instability and the level of sporting ability were recorded. Patients were randomised to undergo surgical repair with either non-absorbable or absorbable anchors.

Results: 130 patients were included in the study. 6 patients were lost to follow up; therefore 124 patients (95%) completed the study. Both types of anchors were highly effective. There were no differences in the rate of recurrence or any of the scores between the two groups. 4 patients in the non-absorbable group and 3 in the absorbable group experienced further episodes of dislocation after a traumatic event: the rate of redislocation in the whole series was therefore 6%. In addition 4 patients, all of them in the absorbable group (4%,) described ongoing symptoms of instability but no true dislocations. 85% of the patients have returned to their previous level of sporting activity.

Conclusions: There are no differences in the outcome of Arthroscopic Bankart repair using either absorbable or non-absorbable anchors. Both are highly effective, showing a redislocation rate of 5.6%.


T Matthews M Brinsden C Hand J Rees N Athanasou A Carr

A prospective study was carried out to determine if recognised histological features seen at surgery could help predict those rotator cuff tendon repairs which re-ruptured. 40 rotator cuff tendon edge specimens from 40 patients’ shoulders were analysed histologically following routine mini-open rotator cuff repair. 32/40 underwent Ultrasonography, at a mean time of 35 months post-operatively, to determine repair integrity. The histological features seen at surgery were then compared to the repair integrity of the tendon from which it had been taken. Rotator cuff repairs that remained intact demonstrated a greater reparative response, in terms of increased fibrobast cellularity, cell proliferation and a thickened synovial membrane, than those repairs which reruptured. Larger tears which remained intact showed a higher degree of vasacularity and a significant inflammatory component than those that re-ruptured. Good tissue quality at the time of surgery allows the repair the best chance of remaining intact despite the size of the lesion. Routine histological analysis of the tissue biopsy, preformed in the post-operatively, can now aid the clinician in terms of early management and repair prognosis.


M. Bains S. Lambert V. Mudera

The purpose of the study was to test the hypothesis that cellular mechanisms of fibroblasts derived from primary frozen shoulder (PFS) exhibit similar activity in terms of contraction, response to cytokine transforming growth factor-beta1 (TGF beta1) and mechanical stimulation similar to that generated by fibroblasts derived from Dupuytren’s disease. Frozen shoulder has been postulated to be Dupuytren’s disease of the shoulder with an association inferred since 1936. Primary explant cultures of fibroblasts from seven patients with PFS and five control patients were obtained using standard tissue culture techniques. Fibroblasts were seeded in 3-D collagen constructs and contraction force generated over 24 hours measured using a culture force monitor (CFM) in real time. Increasing concentrations of TGF-beta1 were added to cell seeded gels and force generated measured using the CFM over 24 hours. These mechanical output data were statistically compared to data available from Dupuytren’s disease. Compared to Dupuytren’s fibroblasts, PFS fibroblasts showed a statistically reduced ability to contract a 3-D collagen gel over 24 hours (p< 0.01). In Dupuytren’s disease, fibroblasts derived from nodules and cords generate peak forces of 140 dynes and 110 dynes respectively, while PFS fibroblasts generated peak force of 8 dynes The response to TGF-beta1 stimulation, which has been shown to enhance peak force contraction in Dupuytren’s fibroblasts had no effect on PFS fibroblasts and this was statistically significant (p< 0.01). These data suggest intrinsic differences in cellular activity and mechanisms between Dupuytren’s and Primary Frozen Shoulder even though clinically they both manifest with a contracted extracellular matrix affecting function and requiring surgical intervention. This may explain increased post surgical recurrence in Dupuytren’s as compared to Primary Frozen Shoulder release.


T. Matthews J. Rees J. Urban A. Carr

The aim of this study was to determine cell viability in different stages of rotator cuff tendon tears using a cell viability molecular probe. Surgical biopsies taken from the edge of the Supraspinatus tendon tear from12 patients, 5 women and 7 men, mean age of 61 years were subjected to a cell viability assay using Molecular Probes Live/Dead cell viability assay. Specimens were then incubated with Calcein-AM and Ethidium Homodimer-1 and following snap freezing, sections were viewed under fluorescent microscopy. Cells which remained metabolically active fluoresced green, whereas dead cells were red. Populations of live and dead cells were counted for each specimen on ten high powered (x400 magnification) fields of view. The results show that the percentage of live cells is reduced in large chronic degenerate tears but greatest in acute traumatic tears. In addition, for those cases where tissue was assayed from the edge of the tear and 1 cm more proximally, there was a considerable increase in the percentage of viable cells in more proximal tissue. Use of this simple assay demonstrates high cell viability and consequently good quality tissue in traumatic tears, but lower quality tissue in larger more degenerate tears. This suggests that traumatic lesions have a high propensity to heal while larger more degenerate tears are less likely to heal but have better quality tissue more proximally.


P Baker R Nanda L Goodchild P Finn A Rangan

Introduction: Scoring systems for assessment of shoulder function are invaluable tools in determining changes in a patient’s condition. We utilised two commonly used assessment tools in patients with conservatively treated proximal humeral fractures to establish their behaviour in this patient group.

Methods: OSS and Constant Scores were collected prospectively at 3 and 12 months post injury, for 103 consecutive patients treated conservatively for proximal humeral fractures. Comparison of the scores was undertaken by creating scattergraphs, calculating Pearson’s correlation coefficient and producing Bland and Altman plots. Sensitivity to change was calculated using paired t-tests. Linear regression analysis was finally performed to predict Constant Score from the OSS.

Results: 177 sets of scores were collected. The scores correlated well with a correlation coefficient (r) of 0.84 (p< 0.001,n=177). This relationship was equally strong at 3 (r=0.77 (p< 0.001,n=94)) and 12 months (r=0.87 (p< 0.001,n=83)) and demonstrated a clear relationship between the scoring systems. Bland and Altman plots showed good agreement between the scores. Both scores were sensitive to change over time (OSS (t(81)=6.14,p< 0.001), Constant (t(80)=−10.27,p< 0.001)). Regression analysis produced a regression equation (R2=0.70) of: Constant Score=99.3-(1.67 times OSS). This level of model fit was statistically significant (F(1,175)=412.8,(p< 0.001))

Conclusion: This study provides information about the behaviour of two frequently used functional scoring systems in patients with proximal humeral fractures. Based on our finding we feel that these scores are appropriate assessment tools in these patients. The OSS may also be considered as an alternative for assessing longer term follow up as, being solely subjective, it is easier to administer and correlates well with the Constant Score.


C. Patsalides N. Hyder T.R. Redfern

Complications in internal fixation of proximal humeral fractures can lead to an unsatisfactory outcome. We retrospectively reviewed 22 patients at a mean follow-up of 13 months (range 3–30). The average age was 58 years (36–86) in 10 male and 12 female patients. The mechanism of injury involved a simple fall in 17, MCA in 3, assault in 1 and metastasis in 1. The operation was performed at a mean of 11 days after the injury (range 1–29). There were 12 3-part, 6 2-part, 2 4-part fractures, 1 fracture dislocation and 1 pathological fracture. Only 13 out of 22 patients (59%) did not develop any complications. We had hardware problems in 5 patients including hardware pull-out, plate prominence, screw penetration, loosening or breakage. 2 wound infections, 1 axillary nerve palsy and 1 peri-operative death. 3 patients (14%) had reoperations to remove the plate, 1 had revision fixation, 1 MUA, 1 open capsular release and 1 I+D of wound. Radiographic union was achieved in 18 patients (82%). We identified a relatively high rate of complications especially in alcoholic or unfit patients. Better patient selection and familiarity with the implant and operative technique are essential for a good outcome. Pain relief and union rate were satisfactory.


C.A. Peach Y. Zhang J. Dunford M.A. Brown A.J. Carr

Cuff Tear Arthropathy is characterised by massive rotator cuff tears, glenohumeral joint destruction and joint effusions containing basic calcium phosphate and calcium pyrophosphate dihydrate crystals. We have investigated the role of the ANKH gene in patients with cuff tear arthropathy and the effect of mutations on protein function. The transmembrane protein ANKH transports inorganic pyrophosphate (PPi) from the intracellular to extracellular space. Control of the extracellular levels of PPi is crucial in preventing calcium crystal formation. Genomic DNA was prepared from peripheral blood leucocytes from 22 patients with cuff tear arthropathy diagnosed clinically and radiologically. All 12 exons and exon-intron boundaries from the ANKH gene were PCR amplified and sequenced with BigDye version 3.1 terminator kit (ABI), and analysed using ABI PRISM ® 3100 Genetic Analyser. ANKH complementary DNA (cDNA) was ligated with mammalian expression vector pcDNA3 and site directed mutagenesis was used to make the ANKH mutation detected in the cases. Human articular chondrocytes were transfected with the cDNA variants and PPi concentrations measured. A G-to-A single nucleotide polymorphism in the 3′ untranslated region (3′UTR) of ANKH was identified. The G/A genotype was seen more frequently in the cases (45%) when compared to controls (20%) (p= 0.0008). We observed altered levels of extracellular PPi in human chondrocytes transfected with ANKH cDNA with the 3′ UTR variant when compared with control cells and normal ANKH cDNA. Cuff Tear Arthropathy appears to be heritable via a G-to-A transition in the 3′UTR of ANKH that alters extracellular PPi concentrations in chondrocyte cells. This supports a hypothesis of a primary crystal mediated arthropathy in patients with Cuff Tear Arthropathy.


J. A. Soler Fernandez S. Gidwani F. Dinah M.J. Curtis

Shoulder rotator cuff tears can be very debilitating and painful. Whilst massive tears may defy attempts at surgical repair due to the size of the defect, various biological materials have been proposed to reinforce tenuous repairs; initial results have been promising. It has been suggested that these materials may be used to bridge defects in the rotator cuff as a ‘patch’ or ‘interposition implant’ to provide pain relief and even offer some hope of functional recovery. A porcine dermal collagen implant (Permacol ©) has been engineered and introduced for the repair and reconstruction of soft tissues in the human body. In orthopaedics, it has been successfully used in the reinforcement and augmentation of rotator cuff repairs by suturing it over the repaired tendon. Proper et al reported good short term results in using this implant to bridge defects in massive rotator cuff tears and suggested it was good solution for this group of patients, reporting improvement in all aspects of the Constant Score. We have used Permacol © to reinforce cuff repairs with satisfactory results and thus considered its use as a salvage procedure to bridge massive rotator cuff defects, both of traumatic and degenerate origins. Unfortunately, we have seen with great concern that our results have been less than satisfactory. In a cohort of 20 patients who underwent Permacol © interposition / rotator cuff repair, 4 of these have failed, despite a promising initial recovery phase with good pain relief. We believe that use of this and similar implants to bridge a defect in the cuff is not indicated; MRI and dynamic ultrasound examination showed an inflammatory response in the shoulder, and resulting weakness/failure of the implant. We present clinical, radiographic, and histological findings of our experience and a discussion as to the probable cause for the failure of this implant in this particular group of patients.


T Baring P Cashman P Reilly AA Amis RJH Emery

There is no non-invasive gold standard for measuring gap formation following rotator cuff repair; re-tears are reported both on MRI and Ultrasound. Roentgen Stereophotogrammetric Analysis (RSA) has previously been used to monitor microscopic migration of markers in rigid bodies. We present a novel RSA technique using a combination of 1mm tantalum beads and metal sutures to allow accurate monitoring of gap formation following rotator cuff repair. The RSA system combines a commercially made calibration cage with software developed at Imperial College. We verified the RSA system by analysing a movable glass phantom and comparing the data with precise physical measurements of the same object: it identified a 2mm distraction of the phantom to within 0.05mm. In vitro work involved cadaveric human shoulders. We placed three 1mm RSA tantalum beads in the greater tuberosity and three metal sutures in supraspinatus tendon. We then created a tear in supraspinatus at its insertion into the greater tuberosity. We were able to show that RSA images taken before and after the tear correlated closely with direct measurements. The processed data demonstrated movement associated with gap formation. We have performed two open rotator cuff repairs using trans-osseous sutures. During surgery RSA markers were inserted into the shoulder to allow post-operative monitoring of the repair (guided by the in vitro work). Direct measurements of the distance between markers each side of the repair were taken intra-operatively (T=O). RSA images were taken immediately post-operatively (T=1 hours), day 3, day 14, and day 84. The RSA data suggests gapping of typically 3mm may have occurred at the repair sites in both patients. Ultrasound imaging was performed at the same intervals by consultant musculoskeletal radiologists blinded to the RSA data. Preliminary results correlating the two modalities suggest that ultrasound can visualise gap formation accurately even immediately post-operatively.


R Skourat S Dhotare S Majid S Kamineni

Background Various methods of analgesia have been described for shoulder surgery, and we routinely used inter-scalene analgesia. We hypothesised that inter-scalene analgesia provided better pain control than intra-bursal analgesia.

Methods We prospectively collected data over a consecutive two year period, with the first year patients (n=65) all having inter-scalene and the second year patients (n=79) having intra-bursal catheters. The interscalene 16F catheters were placed with the patient anaesthetised and an electrical Touhy needle. The intra-bursal 16F catheters were placed at the end of the arthroscopic shoulder operation, under direct vision, exiting from the posterior portal. Pain parameters collected were pain scores, visual analogue scales, analgesia useage, and whether or not the patients were comfortably able to go home the same day as surgery.

Results Pain and visual analogue scores showed no statistical differences between the two groups. Analgesia useage was greater in the inter-scalene group than the intra-bursal group, but was not statistically different. 32/65 (49%) of patients with inter-scalene catheters and 75/79 (95%) of patients with intra-bursal catheters were able to comfortably go home on the day of surgery, 28/33 (84%) of the inter-scalene patients were hospitalised due to post-operative pain, and 5/33 (15%) due to anaesthetic or medical problems. 2/4 (50%) of hospitalised intra-bursal patients had post-anaesthetic complications, and 2/4(50%) had pre-operative medical problems.

Discussion Inter-scalene analgesia is widely published as the most-effective route for post-shoulder surgery pain control. Our data does not support this view, and intra-bursal analgesia administration was found to be more effective at returning a comfortable patient home on the day of surgery. Our practice now routinely utilises intra-bursal catheters for either bolus analgesia or continuous pumps.


K.J. Fairbairn Y.M.K. Aref L. Neumann

Sub-Acromial Decompression (SAD) for impingement has a failure rate of 5–20%. We used MRI to see whether SAD failure is associated with muscle wasting or fatty degeneration in the rotator cuff. Fifty one patients with impingement were assessed using MRI pre- and post-op. Following arthroscopic SAD, seven patients with cuff tears were excluded. This study reviews the pre-op and 6 month post-op MRIs of the remaining 44 patients (25 males; 19 females) and also 17 additional MRIs obtained at three years post-op. MRI assessment was performed by an experienced radiologist using Zanetti’s muscle bulk assessment with values expressed as standard deviations from an age matched mean and Goutallier’s fatty degeneration assessment graded 0 to 4. There was a wide range of pre-op muscle bulk values (SupraSpinatus minus;2.4 to +3.4; SubScapularis minus;2.1 to +4.8; and InfraSpinatus/ Teres Minor minus;1.1 to +5.7). Comparing post-op with pre-op there was a gradual trend towards a reduced muscle bulk for each muscle after surgery but to a limited extent only (< 0.5SD). Pre-op fatty degeneration of SS and IS was grade 2 in about a half with a mild increase with time post-op (SS pre=50%, 6/12 and 3 years=59%; IS pre=45%, 6/12=43% and 3 years=59%). There was a similar age distribution for grades 1 and 2. Only three of the patients were a clinical failure at 6 months but this increased to five of the 17 patients scanned at 3 years. Predicting these failures was not possible based on the pre-op MRI data. The high initial success of SAD was not accompanied by an overall increase in muscle bulk or quality of the muscle at 6 months. The progressive loss of muscle bulk and quality over 3 years was accompanied by an increased clinical failure rate.


F. Lam R. Chidmabaram D. Mok

Aim To evaluate the functional results of rotator cuff function and integrity after arthroscopic excision of calcium and decompression with a minimum follow up of two years.

Methods Between 2002 and 2004, sixty consecutive patients with calcific tendinitis underwent arthroscopic excision of calcium and subacromial decompression. Their average age was 51 years (range 28 to 78). The male to female ratio was 2:3. All patients were retrospectively reviewed by an independent observer. Functional outcome was assessed objectively by Constant scoring system and subjectively by Oxford Shoulder Questionnaire. The integrity of the rotator cuff was assessed by ultrasound scan. (Sonosite). Operative technique After arthroscopic subacromial decompression, all calcific deposits were excised with an arthroscopic rotating blade. The resultant cuff defect was left to heal and no cuff repair was performed. Other intra-articular pathology including SLAP lesions were treated at the same time. Postoperatively, early mobilization of the shoulder was encouraged.

Results The mean Constant score at follow-up was 82 (range 63 to 100). Fifty-four patients (90%) had good or excellent results and six patients (10%) had a fair score. Ultrasound assessment showed intact rotator cuff with no residual defect in forty-three patients, partial thickness tears in twelve, and small full thickness tears in three. Two patients had recurrence of calcium. Only four of the fifteen patients who had ultrasound evidence of rotator cuff tear were symptomatic.

Conclusion Arthroscopic excision of calcium and subacromial decompression is an effective method of pain relief in calcific tendinitis of the shoulder. 75% of the rotator cuff appeared to have healed after two years. Of the remaining 25% patients who had a defect in their supraspinatus tendon, only 6% remain symptomatic.


PJ Wraighte PA Manning WA Wallace

Introduction: Upper limb injuries in road traffic accidents (RTAs) have been sparsely investigated and poorly understood. The purpose of this study was to obtain more specific information on upper limb injuries sustained by front seat occupants in car accidents with a view to identifying injuries that are a priority for prevention and further research.

Methods: With ethical approval and after obtaining identification of cases from the Transport and Research Laboratory the appropriate hospital records and radiographs were reviewed. Data were analysed to identify the frequency and severity of upper limb injuries, the mechanism of injury and the impairment sustained in accordance with the American Medical Association guide. The costs of management of the upper limb injury and that for the patient in total were calculated.

Results: Sixty cases were reviewed (29 male), aged 18–83 years (mean 45 years). There were 19 clavicle fractures of which 17 were right sided, two requiring operative intervention. These injuries were attributed to a “seat-belt” effect. The mean upper limb Abbreviated Injury Score was 1.9 and the overall Injury Severity Score ranged from 1 to 50 (median 12.3). Upper extremity sensory deficit ranged from 0 to 9% and motor deficit 0 to 22.5% giving up to 5% sensory and 13.5% motor “whole person impairment”. The wrist generally suffered a poorer functional outcome compared with the elbow. The mean estimated treatment cost for upper limb management was £2,200 compared with a total injury treatment cost of £11,000 per person.

Conclusions: The study demonstrates the significance of upper limb injuries in road traffic accidents and the data has been used in conjunction with crash dynamics data to formulate recommendations for future car safety and further research.


P Mohanlal N Mayilvahanan R Gangadharan S Annamalai

To evaluate the long term functional and the oncological outcomes of patients who underwent scapulectomy as a limb saving procedure for various tumours of the scapula.

A retrospective study was done in twenty-five patients who underwent scapulectomy for various tumours between 1989 and 2005. We describe twenty-three patients of scapular tumours who were followed up for a minimum of two years after surgery. Nineteen patients had malignant neoplasms of which chondrosarcoma was commonest, followed by Ewing’s sarcoma. Surgical staging was done using Enneking’s system; with stage II B being the commonest. Eight patients underwent subtotal scapulectomy of Malawer Type IIA and fifteen patients underwent total scapulectomy (Type III A). All patients with Ewing’s and Osteosarcoma received neoadjuvant chemotherapy.

With a follow-up ranging from 25–202 months, functional prognosis and oncological outcomes were evaluated for all patients. Two patients had superficial wound infections requiring antibiotics and one had skin necrosis requiring skin cover. Three patients died of pulmonary metastasis and the fourth patient died of local recurrence complicated by multiple metastasis. Functional results were analysed using Musculoskeletal Tumour Society scoring system. The Kaplan Meier 5-year survival computed in 19 patients with malignant tumours was 75.9%.

Scapulectomy is a more realistic option for bone and soft tissue tumours around shoulder girdle. It permits a curative, non-ablative, alternative to forequarter amputation in carefully selected patients.


R. Pennington N. Bottomley D. Neen H. Brownlow

The aim of our study was to assess, for the first time in a large study, whether there are radiological features of the acromioclavicular joint (ACJ) which vary with age or between genders and side. Clinical experience suggested that there was no clear correlation between the radiological features and symptoms arising from the ACJ. Therefore we also aimed to test the null hypothesis that there are no consistent radiological features which correspond with the need for surgical excision of the ACJ. We analysed 240 shoulder radiographs, divided into male and female, left and right shoulders, and decades from 20 to 80 years inclusive. At the ACJ the presence of sclerosis, osteophytes and cysts were recorded, and the width and angle of the joint measured. These same parameters were assessed on the preoperative radiographs for a group of 100 patients by a blinded observer. Fifty had undergone ASD (arthroscopic subacromial decompression), and 50 ASD with ACJ excision. These two groups were age matched. Statistical analyses were performed. There was no statistical difference between any of the parameters for gender or side however with increasing age there was a significantly increased incidence of acromial sclerosis and joint space narrowing. When comparing the matched ASD and the ACJ excision groups it was found that the presence of medial sclerosis of the acromium (p = 0.016) and superior clavicular osteophytes (p = 0.016) were more common in the ACJ excision group. We concluded that there is a change in the radiological features of the ACJ with increasing age but not between sides or gender. The null hypothesis has been rejected. The presence of either medial sclerosis of the acromium, and superior clavicular osteophytes, are radiological features which correlate with a symptomatic acromioclavicular joint.


P Motkur S J Drew S B Rai S M Turner S Karthikeyan

The deltopectoral approach is a common approach for Shoulder joint replacements where a normal subscapularis tendon is divided. Despite meticulous attention to the subscapular repair, suboptimal return of function was found on clinical examination in 92% of patients (Miller S L: Journal of Shoulder & Elbow Surgery. 12(1): 29–34, February 2003). Therefore the aim was to study the integrity of the Subscapularis tendon in patients with Shoulder joint Replacements both clinical and ultrasound examination

Methods: A cohort of 25 subjects who had undergone Copeland Shoulder replacements through deltopectoral approach were included. All patients had same technique of tendon-to-tendon repair and postoperative rehabilitation. After ethics committee approval subjects were evaluated prospectively with Lift off test, Belly press test and the Constant score. Average follow-up was 29.6 months. An experienced Radiologist performed the Ultrasound examination

Results: Ultrasound examination showed 8 % (2 of 25) had full thickness rupture of subscapularis with 44% (11 of 25) showed mild to moderate atrophy of subscapularis muscle and 12%(3 of 25) severe atrophy. 20%(5 of 25) had Lift off test and Belly press test positive. 40%(10 of 25) had either or both of these tests positive. 60%(15 of 25) had clinical or radiological evidence of reduced function (Fisher exact test, P < 0.01). Constant score are 37.5 with full thickness tears compared to 59.4 with intact subsapularis tendon

Conclusion: Subscapularis tendon function following shoulder replacement had received poor attention. It is deficient in over 60% of patients with joint replacement through Deltopectoral approach with tendon-to-tendon repair. We therefore conclude for this study that alternative techniques of subscapularis tendon repair or alternative approaches to the shoulder joint need to be considered to improve the functional outcome in these patients


D. Adla M. Rowsell R. Pandey

Economic evaluation of surgical procedures is necessary in view of emerging, often more expensive newer techniques and the budget constraints in an increasingly cost conscious NHS. The purpose of the study was to compare the cost effectiveness of open cuff repair with arthroscopic repair for moderate size tears. This was a prospective study involving 20 patients. Ten had an arthroscopic repair and 10 had an open procedure. Effectiveness was measured by pre and post-operative Oxford scores. The patients also had Constant scores done. Costs were estimated from the departmental and hospital financial data. Rotator cuff repair was an effective operation in both the groups. At the last follow up there was no statistically significant difference in the patients Oxford and Constant scores between the two methods of repair. There was no significant difference in the time in theatre, inpatient time, post-operative analgesia, number of pre and post-operative outpatient visits, physiotherapy costs and time off work between the two groups. The arthroscopic cuff repair was significantly more expensive than open repair. The incremental cost of each arthroscopic repair was £610 higher than open procedure. This was mainly in the area of direct health-care costs (instrumentation in particular). Health care policy makers are increasingly demanding evidence of cost effectiveness of a procedure. Such data is infrequently available in orthopaedics. To our knowledge there no published cost-utility analysis for the above said two types of interventions for cuff repair. Both methods of repair are effective but in our study open cuff repair is more cost effective and is likely to have better (lower) cost-utility ratio.


D. Nuttall I.A. Trail J.K. Stanley

To measure any observed migration and rotation of humeral and ulnar components using radiostereometric analysis. From 2002–2004 in a prospective ongoing study, twelve elbows in patients treated with either a linked or unlinked Acclaim total elbow prosthesis were included in a radiostereometry study. Six tantalum markers were introduced into the humerus another three markers were located on a humeral component. Four markers were placed in to ulna and three markers located on the ulnar component. RSA radiographs were taken postoperatively, six, twelve and twenty-four months. The radiographs were digitised and analysed using UmRSA software. The relative movement of the humeral and ulnar implants with respect to the bone was measured. At twelve months, the largest segment translation of the humeral component was in the anterior/posterior direction with a mean of 0.44mm followed by medial/lateral translation of 0.39 mm; there was minimal proximal/ distal translation or with a mean of 0.16mm. Paired t-tests between twelve and 24 months segment translation data showed the mean differences to be no more than 0.056mm. The largest rotation at twelve months was anteversion/retroversion with a mean of 2.40deg, anterior tilt had a mean of 1.20deg and varus/valgus tilt was minimal mean 0.60deg. Mean difference between twelve and 24 months segment rotation was no more than 0.30deg. In contrast, humeral tip motion produced a mean of 1.1mm at 12 months dominated by movement in the plane horizontal plane with a mean difference at 24 months of 0.06mm. No patients could be measured for segment micromotion of the ulnar component due to technical difficulty in visualising tantalum markers in the ulna. Early micromotion of the Acclaim humeral implant occurs mostly by rotation about the vertical axis accompanied by anterior tilt. This motion reaches a plateau at 12 months after operation.


H. Mullett V. Venkateswaran T Even S. Massoud O. Levy S. Copeland

Arthroscopic rotator cuff repair has evolved significantly in the last decade and has become a standard treatment. Satisfactory results of arthroscopic subacromial decompression (ASD) in the treatment of rotator cuff tears have also been reported (1). The aim of this study was to compare the outcome following arthroscopic repair versus decompression alone in patients with small & medium rotator cuff tears (Classification of Post, Silver & Singh (2). There were 114 patients in the ASD group and 96 in the Arthroscopic rotator cuff repair group (RCR). The groups were statistically comparable in terms of patient age & gender. Clinical follow-up was performed at a minimum of 12 months post -operatively (average 36 months). The average Post-op Constant score was 69.8 for the ASD group and 86.4 for the RCR group. The average post-op pain score (S.D) in the ASD group was 10.9 (± 4.3) and in the RCR group was 13.6 (± 3.1). Post operative strength was 7.6 (± 3.6) in the ASD group and 16.7 (± 5.4) in the RCR group.26 patients (22.8%) in the ASD group and 3 (3.3%) of the RCR group required futher surgery. Patient satisfaction (maximum 10 points) was 7.4% in the ASD group and 8.9 (± 1.4) in the RCR. The results of this study support arthroscopic rotator cuff repair. Shoulder strength is improved and there is significant reduction in the need for revision surgery.


Ofer Levy Tirtza Even Dipak Raj Ruben Abrahams Mark Webb Eyiyemi Pearse Stephen Copeland

Considerable controversy remains in the literature as to whether hemiarthroplasty or total shoulder arthroplasty (TSA) is the better treatment option for patients with shoulder arthritis. Several cohort studies have compared the outcomes of stemmed hemiarthroplasty with those of stemmed TSA and had inconsistent conclusions as to which procedure is best. However, these studies suggest that stemmed TSA provided better functional outcome. 340 CSRA cases were performed between 1987–2003, 218 Hemiarthroplasty – Humeral Surface Arthroplasty (HSA) and 122 TSA. There was very little difference in the functional outcome and pain in patients with and without a glenoid implant early, as well as, later after surgery. Mean post-operative Constant score for TSA was 85.0% (59.8 points) and for HSA patients 86.8% (62.3 points) with no statistically significant differences (t-test, p=0.4821). A highly significant difference between the overall proportions of revised cases was observed, with (21/122) 17.2% and (6/218) 2.8% of TSA and HSA cases revised, respectively (p< 0.0001). Further, HSA prostheses survive significantly longer than TSA prostheses. The difference between the survival curves was highly significant, both in the earlier post-operative period (Wilcoxon’s test, p=0.0053) as well as the later on (Log-rank test, p=0.0028). Long-term survival of total joint replacement is related to polyethylene wear debris, and therefore its use should be avoided if possible. The difference between our series and those with stemmed prostheses may be due to the fact that with surface replacement the normal anatomy for each patient can be mimicked better than with the stemmed prostheses and there is substantially less place for error as in stem positioning, head sizing or wrong version that may lead to glenoid erosion and less favourable result. Our current practice is and we suggest performing Copeland humeral surface replacement without insertion of glenoid prosthesis.


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F. Qureshi K. Draviaraj D. Stanley

Between 1997 and 2005, 10 patients with chronic instability of the elbow underwent surgical stabilisation. There were 5 men and 6 women with a mean age of 41 years (16 to 58). All patients had initially dislocated the elbow at a mean of 5.6 years (6 months to 25 years) prior to surgical reconstruction. There were 8 chronic lateral and 2 medial reconstructions performed. The presenting symptoms, findings on clinical examination and methods of surgical reconstruction are defined. Two patients underwent reconstruction using an artificial ligament (Corin) as they had evidence of ligamentous laxity and at the time of assessment all the other patients had been treated using autografts. At a mean follow up of 3 years (1 to 6 years) all patients except one reported no symptoms of pain or instability and had been able to return to their normal work and social activity. The one patient with persisting elbow instability had Ehlers-Danlos syndrome and underwent a second revision procedure again using an artificial ligament (Corin). This review represents our surgical experience and functional outcomes with this rare form of ligamentous elbow injury.


A.S. Rajeev S. Thomas J. Pooley

The aim of the study is to assess the humero radial plica which could be a factor in causing lateral elbow pain. The cause of lateral elbow pain has been an enigma for the orthopaedic surgeons over the years. The synovial fold of the humeroradial joint has been well documented and considered as a meniscus between the articulation. They can also present as symptoms suggesting intra articular loose bodies causing pain in these patients. Our study included 117 consecutive elbow arthroscopies performed by two surgeons for a period of 18 months. All patients were initially treated non-operatively as a ‘tennis elbow’ before undergoing arthroscopy. Conservative treatment included rest, activity modification, physiotherapy including ultrasound bracing, nsaids and local corticosteroid injection. All patients were assessed using the Mayo clinic performance index for elbows both pre and post operatively. Radial head plica was found in 21(18%) out of 117 elbow arthroscopies and was resected using a soft tissue resector. There were 16 (76%) men and 5(24%) women in this affected group and all of whom were young and active with a mean age 38 years. Of the 21 patients 16(76%) had a post operative score of 90 or more (excellent) and 5(24%) had a score 75–89(good). This study addresses the fact that cause of lateral elbow pain can be due to various pathologies in the elbow and in the cases of ‘resistant tennis elbows’ we recommend that the existence of a radial head synovial plica should be considered and if present treatment should be directed at this. Our study demonstrates that by resecting the synovial plical fold, pain will be relieved and these patients regained elbow function. Since this was noted in the young active age group this could reduce the morbidity and the time for rehabilitation required especially for those involved in active sports. A similar series has not been cited in English literature


R.T. Benson S. McDonnell J. Rees N. Athanasou A.J. Carr

The aim of this study was to observe the macroscopic and microscopic appearance of the Coracoacromial ligament and Subacromial bursa during Subacromial decompression and correlate it with the outcome at 3 months. Twenty patients with Subacromial Impingement without Rotator Cuff tear and five patients with large/massive irreparable Rotator Cuff tears who underwent a Subacromial Decompression. Patients with other shoulder pathology were excluded. Patients completed an Oxford Shoulder Score pre-operatively and their injection history was noted. At operation the shape of the acromion was noted. The macroscopic appearance of the CA ligament and the Subacromial bursa was classified as normal, mild/moderate and severe. Biopsies of the Subacromial bursa and CA ligament were taken and were analysed using histological and contempory immunocytochemical techniques. A histological analysis was performed using Mayer’s Haemotoxylin and Eosin, Toluidine Blue and Congo Red. Sections were stained with primary antibodies against PCNA (Proliferating cell nuclear antigen), Mast Cell Tryptase, CD3 (T-cell), CD20 (B cell), CD 34 (QBEnd 10), CD45 (Leucocyte Common Antigen), CD68 and D2–40 (Lymphatic Endothelial Marker). Post operatively the patients completed an Oxford Shoulder Score at 3 months. All the patients demonstrated an improvement in their Oxford Shoulder Score. The histological analysis demonstrated thickening of the synovial membrane and increased vascularity within the bursa and ligament. Increased numbers of inflammatory cells were present within the ligament and bursa of patients with impingement compared with massive rotator cuff tears. There was a relationship between outcome and the appearance of the bursa and ligament.


D Shivarathre M Agarwal B Sankar BB Peravali BN Muddu

Percutaneous fixation is a well recognised technique in the treatment of three-part and four-part fractures of the proximal humerus. Minimal fixation of these fractures do show good functional outcome and may further reduce the incidence of avascular complications. We report a preliminary series of 11 patients who underwent percutaneous minimal fixation of such complex humeral fractures using a new technique. 11 consecutive patients (7 with three-part fractures and 4 with four-part fractures) treated by percutaneous limited fixation in our Hospital were involved in this retrospective study. There were 7 fractures with valgus displacement. Percutaneous technique was employed using small incisions and the fracture was reduced under image guidance. The three-part and the four-part fractures were essentially converted into two part fractures, i.e. only the greater and the lesser tuberosities were re-attached to head with AO cancellous screws after realignment of the fragments. The shaft of the humerus was not fixed to the head in any of the cases. All of these cases had a minimum follow-up of at least 6 months. The results were evaluated using the Constant -Murley Shoulder score. 1 out of 11 cases had to be converted to hemi-arthroplasty due to secondary redisplacement of the fracture. The remaining 10 cases showed good bony union although the greater tuberosity in 2 cases showed a residual superior displacement of 3mm and a residual valgus displacement in 2 out of 7 cases. There were no complications of avascular necrosis in any of the cases. Clinically, compared to the uninjured side the average constant score was 93.7% (range- 68.7% – 100%). 7 patients were very satisfied and 4 were satisfied with the operation. Percutaneous minimal fixation achieves good to very good functional outcome comparable to the conventional methods and theoretically reduces the incidence of infection, avascular necrosis and neurological complications.


H. Wynn Jones T. De Smedt S. Sjolin

There is concern that intra-articular electrosurgical ablation may cause thermal soft tissue damage, particularly chondrolysis, if excessive temperatures are reached. The aim of this study was to determine whether the intra-articular temperature during arthroscopic subacromial decompression using a monopolar electrosurgical ablator remains below a safe level. Data was collected prospectively from consecutive shoulder arthroscopic subacromial decompressions performed at our institution. Shoulder arthroscopy was performed using three standard portals. Evaluation of the glenohumeral joint and subacromial space was performed in a standard manner. Soft tissue resection of the subacromial bursa was performed using a monopolar electrosurgical ablator probe with continuous integral suction. Additional procedures such as acromioclavicular joint excision and rotator cuff debridement or repair were performed as appropriate. Bone resection, if required was performed using an arthroscopic burr. The temperature of the fluid within the shoulder and subacromial space was continuously monitored using a sterile digital temperature probe. The surgeon performing the procedure was blinded the collection of data. Data from thirty subacromial decompressions has been collected. 8 patients had full thickness cuff tears of which 6 were debrided, and 2 repaired arthroscopically. 13 patients had acromioclavicular joint excision. Mean operating time was 46 minutes (30–107). The infusion pressure ranged from 40 to 65 mmHg. The median volume of infused fluid was 3900 ml (1500 to 9000). The starting temperature ranged from 18.3 to 21.9. The mean maximum temperature reached was 27.6 (range 22.7 to 41.8 °C). The results suggest that the intra-articular temperature is maintained within safe levels when a monopolar electrosurgical ablator with integral suction is used to perform soft tissue subacromial decompression.


M. Snow L. Funk

Aims To describe the distribution, clinical presentation of SLAP tears in rugby players, and time taken for return to sport.

Method A retrospective review of 51 shoulder arthroscopies performed on professional rugby players over a 35 month period was carried out. All patients diagnosed with a SLAP lesion at arthroscopy were identified. Each patient’s records were reviewed to record age, injury side, mechanism of injury, clinical diagnosis, investigations and results, management, and return to play.

Results The incidence of SLAP tears was 35%. All 18 patients were male with an average age of 27yrs. There were 11 isolated SLAP tears (61%), 3 SLAP tears associated with a Bankart lesion (17%), 2 SLAP tears associated with a posterior labral lesion (11%) and 2 SLAP tears associated with an anterior and posterior labral injury (11%). Of the 18 SLAP tears, 14 (78%) were Type 2, 3(17%) were Type 3 and 1(5%) was Type 4. All patients recalled a specific heavy tackle with fall onto the lateral aspect of shoulder. No patient sustained a complete dislocation. None of the patients presented with symptoms of instability. MR Arthrograms were performed in 17 of the 18 patients. SLAP tears were detected in 13 patients (76%). All patients underwent arthroscopic reconstruction within 6 months post injury. At Arthroscopy 7 patients (39%) were found to have associated injuries. Preoperatively 11% of patients were satisfied with their shoulder. By 6 months post surgery 89% of patients were satisfied and 95% were back to their previous activity level. Patients with isolated SLAP tears returned to sports at an average of 2.6 months post surgery.

Conclusion SLAP tears are a common injury in rugby players with shoulder pain following injury. These can often be diagnosed with MR arthrography. Arthroscopic repair is associated with excellent results and early return to sports.


N.D. Clement A.N. Stirrat F.M. Khaw R.C. Colling

To identify the incidence and timing of superior subluxation following total shoulder replacement (TSR) and any associated change in pain, activities of daily living and ranges of movement. Forty-six TSR in rheumatoid patients with more than 5years follow-up were identified from a prospectively compiled database held by the senior author (ANS). Modified Constant scores (excluding the power component) were measured and recorded prospectively every 2years. Pre-operative and complete follow-up scores were available for 35 joints (27 patients). A Mann-Whitney U test was used to compare patients with subluxation and those without, with regard to the changes in the components of the Constant score at last follow-up compared with the pre-operative score. Superior subluxation of the humeral head was defined as when the lower third of the humeral head had migrated level or superior to the midpoint of the glenoid component as measured on the AP radiograph. An independent observer reviewed AP radiographs, taken at each 2 yearly review, at random with identity hidden and in no particular date order. Twenty-three patients developed superior subluxation since surgery, of which 87% occurred after 5years. Of the 35 joints with both clinical and radiological follow-up, 16 had evidence of subluxation. There was no statistically significant difference between the changes in the activities of daily living (Mann-Whitney U=106, p=0.1) and range of movement (U=140, p=0.7) components of the Constant score. However, patients without subluxation had a greater improvement in their pain scores (U=80, p=0.02). Approximately half of rheumatoid patients with TSR will demonstrate radiological changes of superior subluxation, in the majority after 5 years. This change is not associated with deterioration in activities of daily living or ranges of movement. However, pain relief persists irrespective of subluxation but is better maintained in those without subluxation.


J John CP Kelly

Assesment at teaching courses has been restricted to subjective assessment by questionnaire of the quality of teaching sessions and the teachers. This does not give any information on the extent of learning by the participants. Formal skills assessment during a practical course can be complex, time consuming and may distract from the teaching process. The purpose of the study was to quantify learning at a skills course on open shoulder surgery using a knowledge based questionnaire before and after completion of the course.

Method: 22 participants at a two day shoulder surgical workshop completed a knowledge questionnaire before (entry assessment) and immediately after completion (exit assessment) of the course. Four participants were excluded because of incomplete forms. The questionnaire consisted of 10 multiple choice questions which represented the content of the programme. The questionaires were scored and the change in score calculated for each participant and expressed as a percentage of the initial score. An improvement in the score defined a positive learning experience.

Results: There was a positive learning experience for all participating surgeons. The average improvement was 17% {range 4–43%}. The pre course scores ranged from 43 to 92% {average 68.8%}, while the post course scores ranged from 67 to 100% {average 85.5%}. The improvement was dependent on the initial score, trainees with low initial scores registering the maximum percentage recorded increase in knowledge ie 23% (range 5–43%). We did not identify a relationship between grade of surgeon and learning as measured with this assessment.

Conclusions: Simple learning assessments can demonstrate and quantify learning experience at skills courses. The process is not time consuming and can be easily integrated into the structure of a course.


S Hossain LGH Jacobs R. Hashmi

We evaluated the long-term benefits of steroid injection in 20 consecutive patients (25 shoulders) with primary acromioclavicular arthritis using the Constant score. All patients were followed up for a minimum of 5 years. The average age of the patients was 55 years. The mean pre-injection Constant score was 61 points. At six months this improved to 81 points, (mean difference – 19.36) which was highly statistically significant (p< 0.01). There was further improvement at 12 months, on the 6-month score, mean 86 points that also showed a significant improvement on the 6-month score (p = 0.001). At 5 years the mean score was 81 points and this was a significant detoriation compared with the 12-month score (p=0.01) but still a significant improvement when compared to the preinjection scores (p< 0.0005). In addition, the younger the patients, the greater the improvement in the objective score which measures range of movement and power (r= − 0.47; p= 0.01). Female patients also had a greater improvement (r=0.405; p=0.05). We conclude that local steroid injection is an effective method of treatment for primary isolated acromioclavicular arthritis and improvement continues for at least 12 months and the benefit is felt up to 5 years though the pain relief tends to tail off long-term.


C.D. White T.D. Bunker R.M. Hooper

Given that there is limited time available to the surgeon in arthroscopic rotator cuff repair, how is the time best spent? Should he place one Modified Mason-Allen, two mattress or four simple sutures? This study reverses current thought. In an in-vitro biomechanical single pull to failure study we compared the ultimate tensile strength of simple, mattress and grasping sutures passed with an arthroscopic suture passer (Surgical Solutions Express-Sew). The aim was to determine which suture configurations would most simply, repeatably and reliably repair the rotator cuff. The ultimate tensile strength and mode of failure of six different suture configurations was repeatedly tested on a validated porcine rotator cuff tendon model, using a standard suture material (Number 2 Fiberwire) passed with the Surgical Solutions Express-sew, in a Hounsfield type H20K-W digital tensometer. Standardising the number of suture passes to four, the strongest construct was two mattress sutures (Mean 169N), followed by single Modified Kessler (Mean 161N), four simple sutures (Mean 155N) and finally a single Mason Allen suture (Mean 140N). Suture configurations involving two passes were all weaker than those with four (one way analysis of variance p=0.026), even when Number 2 Fibertape was used to augment strength. These results show little difference in strength for varying complexity of four pass suture passage (one way analysis of variance p=0.61). In simple terms there is no demonstrable difference in the strength of construct whether the surgeon uses four simple, two mattress or one grasping suture. This study allows the surgeon to justify using the simplest configuration of suture passage that works in his hands in order to obtain a reliable and repeatable repair of the rotator cuff arthroscopically.


R. Sharma S. Mc Gillion J. Sinha A. F. G. Groom

We have reviewed the management and outcome of ununited fractures of the humerus in a specialist limb reconstruction unit. A retrospective study conducted at Kings College Hospital, including referrals during the period September 1994 to present. There were 47 cases of humeral non-union, (14 proximal, 25 diaphyseal and eight distal). The time of referral from injury ranged from two months to eight years, with one patient referred after 37 years. 38 of the 47 patients had undergone an average of 1.08 operations prior to referral. Treatment aimed to achieve alignment, stability and stimulation. Methods were as follows: Proximal fractures [14]: nine Locked Compression Plate (LCP), five Dynamic Compression Plate (DCP). Autologous bone graft alone [eight], Bone Morphogenic Protein (BMP – Osigraft) alone [three], both bone graft and BMP [three]. 13 have united. One is under treatment. Mean time to union was six months. Diaphyseal fractures [25]: 12 LCP, four DCP, five Intramedullary (IM) nail, one Ilizarov frame and one required observation only. Autologous bone graft alone [17], BMP alone [two], both bone graft and BMP [three]. 23 have united. One patient awaits surgery. One patient declined surgery. Mean time to union was four months. Distal fractures [eight]: four LCP, two DCP, two Ilizarov frames. Autologous bone graft alone [seven], both bone graft and BMP [one]. Seven have united. One is under treatment. Mean time to union was seven months. Open reduction and appropriate stabilisation, together with the stimulus of autologus bone graft and/or BMP consistently resulted in healing of ununited fracture of the humerus. Many treatment methods were employed. It is not clear whether it was the treatment method or the accumulated experience of the Limb Reconstruction Unit, which was responsible for a high success rate comparable to, or better than, published results.


M. Snow L. Funk

We present an all arthroscopic technique for modified Weaver Dunn reconstruction of symptomatic chronic type III ACJ joint injuries. Over a one year period we performed 12 all arthroscopic modified Weaver-Dunn procedures. All patients had failed non-operative management for at least 6 months. The technique involved excision of the lateral end of clavicle, stabilisation with a suture cerclage technique from 2 anchors placed in the base of the coracoid and coracoacromial ligament transfer from the acromion to lateral end of clavicle. Post-operatively the patients were immobilised for six weeks, followed by an active rehabilitation programme and return to work and sports at 3 months. We have currently performed this technique in 12 patients, all male. The average age at operation was 25.8yrs at a mean interval of 11 months post injury. The mean Constant score preoperatively was 49 (44–54). The mean 3 month postoperative Constant score was 88.6 (84–96). There have been no complications, and the 2 professional sportsmen within our cohort returned to full contact at 3 months. Due to an irreducible clavicle, one patient required an open excision of lateral clavicle, with the rest of the procedure performed arthroscopically. Arthroscopic Weaver-Dunn has a number of advantages over the corresponding open procedure. It avoids the detachment of deltoid needed to gain exposure and also the morbidity from the wound. From our experience is that it enables patients to regain their function more rapidly with an earlier return to sporting activities. The early results from our initial experience have been excellent, with no complications. With this technique an anatomic reconstruction can be achieved with excellent cosmesis, low morbidity and potentially accelerated rehabilitation.


H O Amadi A M J Bull U N Hansen

Many different clinical examinations are used to assess instability of the glenohumeral joint. Validation of these includes clinical data, follow-up, imaging, and arthroscopy. In spite of these many works, there currently exists no clear unique method for identifying and validation novel clinical examinations. The aim of this study was to use a computational tool to quantify the specificity of clinical examinations in assessing glenohumeral ligament (GHL) pathology. Five GHLs were modelled according to the literature [1]. Physiological kinematics data [2] were applied to simulate 23 clinical examination manoeuvres for the glenohumeral joint. Individual ligament forces were computed as a percentage of the total ligamentous restraint. The 0° abduction anterior-laxity test was most specific for the superior GHL (82.3%). The anterior apprehension in the coronal plane and 90° anterior-laxity tests were specific for the anterior band of the inferior GHL (abIGHL – 100%). Pure scapular plane abduction and the 90° abduction inferior-laxity tests were specific for the axillary pouch of the IGHL (apIGHL – 100%, 89.6%). Specific tests for posterior band of the IGHL were posterior apprehension (95.1%), 0° and 20° abduction posterior-laxity, and 30° to 45° flexion Norwood and Terry test (100% each). The middle GHL did not exhibit any exclusive loading pattern for any of the tests. A secondary insertional morphology was simulated with the abIGHL positioned at the 4 o’clock position as opposed to the 3 o’clock position [1,2,3]. Significant loading differences were computed for the same ligaments during the same tests. This study demonstrates the sensitivity of specific tests for individual GHLs, but provides the significant caveat that ligament loading is significantly influenced by normal anatomical variations.


Mr. SD Purushothamdas Mr. J Arora Mr. MM Scott Dr. N Corbitt

The aim of the study is to compare the postoperative pain relief provided by continuous perfusion of wound by bupivacaine and fentanyl with that of patient controlled analgesia using morphine in elective shoulder surgery. This retrospective case control study included 76 consecutive patients who had elective shoulder surgery. 39 patients had patient controlled analgesic system (PCA) with morphine and 37 patients had a continuous wound perfusion with bupivacaine and fentanyl via a disposable Silicone Balloon Infuser. Patients were also given additional oral NSAIDs or morphine if needed. The pain score measured postoperatively based on a 10 point Visual Analogue Scale (VAS) at 1, 2, 3 and 18 hours was noted. The use of antiemetics and additional painkillers was recorded. The complications of both methods were also noted. We found that the analgesia provided by continuous perfusion of wound by bupivacaine and fentanyl was constant and comparable to that provided by the patient controlled analgesic system using morphine. PCA with morphine was associated with significantly high incidence of nausea and vomiting (p < 0.001). We conclude that continuous perfusion of the wound by bupivacaine and fentanyl appears to be a simple, effective and safe method of providing analgesia following elective shoulder surgery.


I. Gill S. Graham A. Mountain M. P. M. Stewart

To evaluate a peri-operative protocol developed to facilitate day case open shoulder procedures that historically have required overnight hospital admission. 75 consecutive day-case open shoulder procedures were performed in 75 patients (aged 18 – 65) followed up prospectively for a minimum of 6 months. The procedures included Open Primary Anterior Capsulo-Labral Reconstruction (ACLR) (24), open Revision ACLR (4), open Posterior Capsulo-Labral Reconstruction (2), mini-arthrotomy and rotator cuff repair (6), mini-arthrotomy and sub-acromial decompression (28), modified Weaver Dunn Reconstruction of Acromio-clavicular joint (ACJ) (2), decompression of ACJ (7), open release for frozen shoulder (2). Exclusion criteria included concomitant medical problems, and patients who would have no assistance in their care for the first 24 post operative hours. All patients received general anaesthesia, peri-operative analgesia using intravenous Fentanyl, and Diclofenac (PR), and local Bupivicaine 0.5% to incisions and intra-articular spaces; patients were discharged with oral analgesics. Patient satisfaction with overall experience, pain control, the incidence of nausea that was difficult to manage, the incidence of unplanned admission, attendance or delayed admission to hospital and postoperative complications were measured. 98% of patients were satisfied with their pain management. None of the patients suffered intractable post operative pain, nausea or vomiting; none required unplanned hospital admission or unexpected re-admission. All the patients were satisfied with their overall experience. There were no short or long term post operative complications. In conclusion, the anaesthetic protocol and surgical techniques used in this study permitted same day discharge for a wide variety of open shoulder procedures. For selected patients, open shoulder surgery as a day case appears to be safe effective and acceptable to the patient.


A. Richards D. Potter D. Learmonth D. Tennent

Purpose of Study Disruption of the coraco-clavicular ligaments may be associated with either dislocation of the Acromioclavicular joint or fracture of the distal clavicle. If sufficient displacement occurs functional disability results. Traditional techniques have required a bra-strap incision and often require late removal of the metalwork. The Tightrope syndesmosis repair system was adapted to be used arthroscopically to reduce and hold the clavicle enabling healing of the ligaments and any associated fracture using a minimally invasive technique but ensuring accurate reduction and secure stabilisation. Between December 2004 and September 2005 20 patients with injuries to the coraco-clavicular ligaments were treated using this system. As the system was in evolution a the majority were treated arthroscopically and a few using an “open” technique. All had either the acromio-clavicular joint reduced or a distal clavicle fracture reduced and stabilised using the Tightrope Syndesmosis Repair system. The system had been modified from that commercially available for use in the ankle with the consent of the manufacturer (Arthrex, Naples, Fla).

Results All patients were evaluated at a minimum of 6 months post operatively using the DASH, ASES and Constant scores The mean ASES score was 94, the mean Constant score was 90, the mean DASH score was 5 One patient had failure of the metalwork due to malposition, this was revised successfully using the Tightrope and one had a transient adhesive capsulitis. There were no other complications and no patient required removal of the metalwork.

Conclusions The authors conclude that this new technique is a safe, simple, cosmetically acceptable and reproducible method of reducing and stabilising the distal clavicle allowing for healing of either the coraco-clavicular ligaments or the distal clavicle.


S. Karthikeyan S. Rai S. Drew

The use of high resolution ultrasonography for the detection of rotator cuff tears has achieved only limited acceptance by orthopaedic surgeons. Uncertainty about the accuracy of ultrasonography may be a contributing factor. The purpose of this study was to evaluate the accuracy of high-resolution ultrasonography compared to shoulder arthroscopy in the detection of rotator cuff tears. 100 consecutive patients with shoulder pain in whom arthroscopic surgery was planned underwent standardized preoperative ultrasonography. The ultrasound examinations were done by a single experienced musculoskeletal radiologist using a standard protocol. The findings at ultrasound were classified into intact cuff, tendinopathy, partial-thickness tear, and full-thickness rotator cuff tears. The size of the tear was measured in centimetres. The location was designated as subscapularis, supraspinatus, infraspinatus, or a combination. All of the subsequent shoulder arthroscopies were done by a single surgeon. The presence or absence of a rotator cuff tear and the size and extent of the tear when present were recorded. We then compared the ultrasonographic findings with the definitive operative findings. For the detection of rotator cuff tears, ultrasound had a sensitivity of 95% and a specificity of 94%; accuracy 95%. There was 100% sensitivity for full thickness tears (specificity 91% and accuracy 95%), while for partial-thickness tears there was a sensitivity of 80%, (specificity 98% and accuracy 95%). In experienced hands, ultrasound is a highly accurate diagnostic method for detecting rotator cuff tears. The results of this study compare favourably with the published results of magnetic resonance imaging for the investigation of this condition. Furthermore, dynamic imaging and comparison with the opposite shoulder is possible with ultrasonography.


W Angus Wallace

Background: Instability of the Sterno-Clavicular Joint (SCJ) can occur due to indirect trauma or ligament laxity. Reconstruction of unstable SCJs has focussed on extra-articular procedures aimed at either holding the medial clavicle downwards or backwards (for anterior subluxation), and often attempting to re-create the Costo-Clavicular CC ligament effect.

Methods: Experience of clinical traumatic injuries where the intra-articular meniscus of the SCJ was disrupted has highlighted the importance of this structure in stabilising the SCJ. This meniscus, through its attachments to the sternum medially and the clavicle laterally, may have a greater effect on the stability of the joint than previously realised – much greater than the stabilising effect of the CC ligament. Anatomical studies of the intra-articular disc, its attachments and the effect of dividing the CC ligament have been carried out on anatomical and fresh frozen cadaver specimens.

Results: Division of the CC ligament alone has only a small effect on SCJ stability. However division of the SCJ disc with the CC still intact has a significant effect on SCJ stability. It is now suspected that patients with joint laxity associated with SCJ anterior subluxation have pathology affecting the SCJ disc and this will be described. An embroidered polyester SCJ augmentation device has been designed to re-create the stabilising forces initially generated by the SCJ disc before stretching or tearing has occurred. This device has been designed to be inserted within the SCJ disc (if present) and anchored to the sternum and clavicle using screws with a technique that recreates stability to the joint. The biomechanics of this reconstruction with pictorial demonstrations of the effect of this stabiliser will be described.

Discussion: Our understanding of the stabilising structures of the SCJ is only now becoming clearer. With this knowledge, improved methods of managing SCJ problems may now be developed.


Garth R Johnson Donald Buchanan W Angus Wallace Andreas Kontaxis Gabriel Gueugnon Livio Nogarin

Background: The Delta Inverse Shoulder Arthroplasty, has gained considerable popularity in France and Europe for Rotator Cuff (RC) deficient patients. However complications related to surgical difficulties with insertion, mechanical loosening, and polyethylene (PE) wear are now being reported. The increasing numbers of complications are alarming.

Methods: A computerised analysis of the kinematics associated with inverse shoulder replacements has been developed. Different glenoid dome sizes and humeral cup dimensions have been tested. This has highlighted the deficiencies associated with the design of the inverse shoulder prostheses currently available on the market. Modifications of the prosthesis geometry and the inclusion of a mobile bearing have also been subjected to computer analysis and have demonstrated improved kinematics and a reduction in the risk of bone/prosthesis contact. A medium term follow-up of 9 patients with a mobile bearing Inverse shoulder design has been carried out. Compression tests have been carried out on the PE bearing to identify the risk of plastic deformity of the PE.

Results: The results of the computerised analysis and the clinical results from the first 9 patients will be reported. One patient suffered an operative complication with failure of reduction of the prosthesis which was rectified at an immediate re-operation. The early clinical results are similar to the good results obtained with the Delta prosthesis. However polyethylene bearing failure has occurred in one case, highlighting the importance of optimising the geometry of the inverse shoulder. Both Radio-Stereometric Analyses (RSA) and prospective randomised studies comparing this Inverse prosthesis with either a Cuff Tear Arthropathy (CTA) hemiarthroplasty designes (when Gleno-Humeral(GH) OA is present) or with cuff reconstruction using augmentation (when no GH OA is present) have been designed and will be discussed.


K.P. Draviaraj F Qureshi Kato D. Potter

Assess the outcome of plating of lateral end clavicle fractures. Lateral end clavicle fractures can be treated both conservatively and surgically. Different surgical methods are available to stabilize lateral end clavicle fractures. We treated 15 lateral end clavicle fractures with plate fixations (4 AO ‘T’ plate and 11 ACUMED lateral clavicle plate) from September 2002 to December 2005. There were 12 males and 3 females and the mean age was 33.12 year (range 23–61). 3 were done for non-union and 13 for acute fractures. 2 non-unions were treated with AO ‘T’ plate and 1 with ACUMED lateral clavicle plate. 1 patient with non-union had bone grafting at the time of the procedure. Acute fractures were stabilized with in 3 weeks from the time of the injury. All fractures were Type 2 according to Neer classification of lateral end clavicle fractures. The cause of the injury was, simple fall (3), fall from pushbike (3), assault (3), sports/skate-board (3), and RTA (3). The senior author operated on all patients. The arm was immobilized in a sling for six weeks post operatively. The follow up ranged between 5 months to 36 months All but one fracture healed. 1 ‘T’ and 1 ACUMED plate was removed 7 months after the index procedure after fracture consolidation. There was no superficial or deep infection. Patients were assessed clinically with Constant and DASH scores; patient satisfaction with the procedure was also recorded and union assessed radiologically.. Lateral end clavicle fractures pose a challenge due to the small size of the distal fragment. In our experience plating of these fractures give satisfactory results. Oblique fracture patterns result in better fixation and union rates. The plate design and advantages of the ACUMED contoured distal clavicle plates are further discussed in the paper.


R. Jeevan B. Roy L. Neumann W.A. Wallace

We aimed to test the biomechanically predicted hypothesis that in massive rotator cuff tears irreparable by conventional methods the newly developed Nottingham Augmentation Device (NAD) would provide greater functional improvement than that gained from the gold standard of arthroscopic subacromial decompression. Thirty patients treated between 2001 and 2004 were assessed by pre- and six month post-operative Constant scoring. Fifteen underwent open acromioplasty and cuff reconstruction using the NAD (mean age 67.3), while 15 underwent a standard arthroscopic decompression (mean age 67.4). The two groups were matched retrospectively based on size of cuff tear, age and sex. Data was analysed using the student’s t-test at the 95% confidence interval. Both groups displayed a statistically significant increase in Constant score after surgery. The mean increase for NAD patients was 18.7 points compared with 17.6 points for those undergoing arthroscopic decompression. However there was no significant difference between the two groups’ improvement and this was even so in the power sub-category, where increased benefit was predicted with the NAD. The NAD requires greater surgical access, operating time and peri-operative analgesia, and no active mobilisation for six weeks. The arthroscopic technique is minimal access, rapid, involves no prosthesis or foreign body insertion and allows immediate mobilisation. However, with clear biomechanical benefits of the NAD seen in vitro, our results may simply reflect cuff tears in an older population group with irreversible tissue changes and less rehabilitative potential. A randomised prospective trial in a younger patient group with more acute tears and less tissue atrophy would appear the next step in determining the NAD’s place in the management of massive rotator cuff tears.


S. Srinivasan A.L. Armstrong

We undertook this study to evaluate our results of Arthroscopic Capsular Shrinkage as a treatment of Multi Directional Instability of the shoulder. Patients with symptomatic multidirectional instability (MDI) have excess capsular laxity. Arthroscopic capsular shrinkage is a fairly new procedure, to treat laxity with variable results in the reported literature. We analysed the records of patients who under went 20 (10 males, nine females) arthroscopic thermal capsular shrinkage procedures for MDI of the shoulder, which were performed by the senior author between 2000 and 2004. The mean age was 28.3 years (median 29.4, range 18 to 46 years) and the mean follow up was 44.5 months (median 43, range 20 to 69 months). All patients had undergone specialist shoulder physiotherapy for four months or more prior to surgery. The type of shoulder instability was subcategorised (based upon the predominant symptomatology as perceived by the patient) as follows: dislocation (seven), subluxation +/− pain (nine), and impingement (four). The procedure and postoperative regimen were standardised. Clinical outcome measures were: patient satisfaction, pain and instability. Sixteen shoulders (80%) were symptom free and fully satisfied at last follow up. One patient (5%) had some pain but a stable shoulder. Three patients (15%) [two dislocators and one subluxator] had recurrent instability between six to eight months post operatively and underwent further surgery. The less the instability, the more likely it was, that the procedure would succeed. We conclude that out results are encouraging particularly in patients with less severe instability despite the small size (20) of our cohort of patients. We think that careful patient selection may be important for success from this surgery.


M R Webb N Bottomley S A Copeland O Levy

Introduction The value of collecting continuous prospective patient data, including operation records and outcome scores, is well known. In 1994, a systematic prospective patient data collection was initiated on all patients attending the Reading Shoulder Unit (RSU). Initially this was done with hand written records. In 1995 a Windows Access ® database was formulated on a portable laptop. This was used continuously through until September 2005 when an Internet web-based database was introduced. We present this collective data and trends in practice from a busy shoulder unit over this decade. Results Between 1995 and 2005, 10005 entries were made to the Reading Shoulder Unit database. 3233 patient visits to outpatient clinics were recorded. 6772 operations were recorded – this includes: arthroscopic decompressions (ASD) + AC joint excisions − 3514, MUA for frozen shoulder 842, shoulder arthroplasty 432, open stabilisation 356, arthroscopic stabilisation 192, arthroscopic rotator cuff repair (RCR) 402, open cuff repair 290, arthroscopic capsular release 78 and 248 trauma cases. Changes in the unit practice include the move from open to arthroscopic reconstructive surgery (RC and stabilisation), RCR rather than ASD alone in elderly patients with impingement and cuff weakness, and repairing partial rotator cuff tears when previously we did not. Conclusions With over 10000 continuous and prospective entries – the RSU database is invaluable for continuous audit of practice and assessment of outcomes of the different procedures. Several practices have changed through the decade; most notably from predominately open reconstructive surgery through to arthroscopic reconstructive surgery. We would recommend to every surgeon and unit to collect his own data prospectively to enable him to analyse and assess his results.


C.M. Baldwick T.D. Bunker N.C. Giles A.C. Redfern D.A.T. Silver

There is debate regarding the most appropriate treatment of calcific tendinitis. Minimally-invasive techniques with image-guided needling of the deposits have been developed to provide an alternative solution. We present the results of fluoroscopically-guided barbotage in 100 patients. One hundred patients with acute or chronic shoulder pain, visible on plane radiographs or ultrasound scan, were referred from the Orthopaedic Department for barbotage over a six-year period. This study is a retrospective review of the results of barbotage in these patients, using a patient-based questionnaire. Forty three patients ultimately required arthroscopy of their painful shoulder. However, at surgery, the calcific deposits were noted to have dispersed in the majority of these patients. In addition there was often a long symptom-free period between the initial barbotage and recurrence of pain. In many cases the nature of their symptoms had changed and at arthroscopy signs of impingement or rotator cuff tears were common. Barbotage eliminated the need for more invasive surgery in over half of the patients in this study. It should be considered in all patients with calcific tendinitis refractory to non-operative treatment.


A.S. Bajwa R. Nanda S. Green P Gregg A Port

To identify mechanisms of failure in plate and nail fixation in proximal humerus fractures. 5% of the proximal humerus fractures need surgical fixation, which is carried out, principally, by open reduction and internal fixation or closed reduction and intramedullary nailing. Fixation failure remains a problem. This study answers the mode of failure of these implants regardless of the fracture personality. In-vitro testing of proximal humerus fixation devices was undertaken in 30 simulated osteoporotic bone models. Fracture-line was created at the surgical neck of humerus in all samples and fixed with five fixation devices; three plating and two nailing devices. The samples were subjected to failure under compression and torque. Failure was achieved in all models. Three failure patterns were observed in torque testing:

The two conventional plates Cloverleaf and T-plate behaved similarly, failing due to screw pull-out from both the proximal and distal fragment with a deformed plate.

The PHILOS plate failed by avulsion of a wedge just distal to the fracture site with screws remaining embedded in the bone.

Both the nailing systems, Polaris and European humeral nail, failed by a spiral fracture starting at the distal locking screw. In compression testing the modes of failure were:

The Clover-leaf and T-plate failed by plastic deformation of plate, backing out of the screw in the proximal fragment followed by fracture of the distal fragment.

The PHILOS failed by plastic deformation of plate and fracture of the distal fragment distal to the last locking screws.

In both the nails, the proximal fragment screws failed.

The failure mode is dependent on implant properties as well, independent of the fracture personality. It is important to recognise the potential points of failure (proximal or distal fragment) when making the choice of implant to avoid fixation failure.


C.D. Smith S. Masouros A.M. Hill A.M.J. Bull A.L. Wallace A.A. Amis

The aim of this work was to define the tensile material properties of the glenoid labrum. Previous SEM studies of the labrum have observed three definitive layers, with a densely packed circumferentially orientated collagen core layer. The glenoid labrum from ten cadaveric shoulders were dissected out and divided into eight equal sections. Each section was cut to produce specimens from the core layer using a microtome and a specifically designed cryo-clamp resulting in uniform specimens with dimensions of 1mm x 1mm x 8mm. All of the tensile testing was performed within a controlled-environment unit of 38°C and 100% relative humidity. Each specimen was precycled to a quasi-static state to alleviate the effects of deep-freezing, prior to final testing. The elastic modulus was calculated for each specimen before and after a 5-minute period of stress relaxation and before failure initiation. The mean age of the specimens was 61 years (range 47–70). Load to failure was 2.7N (1.0–7.0). The mean modulus was 10.2MPa (3.0–22.3) before stress relaxation, 18.0MPa (5.8–36.7) immediately after stress relaxation and 22.3MPa (8.4–66.4) before failure initiation. The 1 and 2 o’clock specimens had lower moduli than the 4 and 5 o’clock specimens (p=0.01). These results can aid in explaining the differing pathologies encountered around the circumference of the labrum. The high moduli at the 4 and 5 o’clock positions may reflect the ability of this portion of the labrum to accommodate forces and thus resist anteroinferior subluxation. The lower moduli at the 1 and 2 o’clock positions suggest that this portion of the labrum is less apt to accommodate tension; this might explain the higher incidence of labral foramen observed in this area and the anatomical variant of the Buford complex.


Y. Aref L. Neumann J. Fairbairn

Aim: To assess the outcome of arthroscopic subacromial decompression on rotator cuff muscles

Material: 44 patients with impingement syndrome and intact rotator cuffs were recruited 3 years ago. All were followed up 6 months after surgery and 17 were selected randomly to attended after 3 years.

Methods: All patients prior to surgery underwent:

Clinical examination.

Constant Scoring.

Cybex testing of the rotator cuff muscles.

MRI scans.

Arthroscopic examination followed by arthroscopic SAD.

Standard post-op rehab.

Tests were repeated at 6 months, and in 17 patients again 3 years after surgery.

Results: 1– 41patients (93.18%) improved subjectively at 6 months, and 12 (out of 17) were still satisfied after3 years. 3- Impingement signs disappeared in 41 patients at 6 months and in 13 out of 17 at three years. 4- Average increase in Constant score was 18 points at 6 months and 4 points at 3 years. Pain ADL Pos. ROM Power Total Pre-op mean 5.71 5.23 5.23 25.45 8.76 50.38 Post-op mean 11.67 8.04 8.14 38.05 20.9 86.8 3 years mean 10.91 8.02 7.83 42.78 16.6 86.14 5-Dynamometer (Cybex) Muscle testing: Average power in Watts Abduct Adduct Int. Rot. Ext. Rot. Int. Rot. Ext. Rotation at side at side at 90abduct at 90abduct Pre-op 40.01 61.3 38.2 23.12 32.56 27.78 6/12 postop 54.78 76.6 51.93 36.34 40.74 39.19 3 years p.o. 52.65 69.98 52.77 38.55 40.78 36.21

Conclusions

SAD still provides good pain relief

Muscle power increases post-operative but tends to plateau or slightly decrease after 3 years

Dynamic muscle power measurement is recommended for accurate assessment.

Other Cybex measurements (Torque) had little relation to clinical outcome.

Constant score does not accurately assess changes in muscle power.


K.A.Z. Sivardeen M. Green S.N.F. Massoud D.J.A. Learmonth

The aim of this study was to review the results of surgery on patients who had recurrent instabilty of the shoulder associated with significant bone loss who were treated by autogenous iliac crest tricortical grafts. Ten consecutive patients were reviewed. All had significant loss of glenoid bone stock as assessed by CT scan. All were treated by use of tricortical bone graft harvested from the iliac crest and fashioned to reconstitute the anterior glenoid defect. This was fixed intra-articularly with cannulated screws. The antero-inferior capsule was then repaired to this new “glenoid rim”. All patients had a standard rehabilitation regime. All patients had an assessment of the Oxford Shoulder Instability Score (OIS) and the American Shoulder and Elbow Surgeons Score (ASES) before and after the operation. At an average follow-up of 26 months, the mean OIS had improved from 38.3 to 22.3 and the mean ASES had increased from 40.5 to 86.6. None had had a recurrent dislocation. The use of autogenous iliac crest bone graft to treat recurrent shoulder instability associated with significant glenoid bone loss is an effective treatment for this difficult condition.


S Alshryda V Tripurneni R Vinayagam P Raju N C Bayliss

Background: One stop shoulder clinic was established in the North Tees University Hospital as part of conjoint effort between the department of trauma and orthopaedics and radiology in the year 2005. A consultant shoulder surgeon, consultant radiologist, extended scope shoulder physiotherapist and shoulder nurse practitioners run the clinic on weekly basis.

The aims are:

Immediate and more accurate diagnosis and plan accordingly.

Avoid unnecessary or inappropriate treatment while waiting for radiological test.

High patient satisfaction.

Reduce waiting time for definitive treatment.

Reduce number of patients’ visits.

Improve and advance clinical and radiological skills.

Reduce the cost to the NHS.

Promote a multi-disciplinary approach to patient healthcare.

Methods and materials: A retrospective study of 150 patients who had been seen in the one stop shoulder clinic and conventional clinic. We studied the number of hospital visits, the waiting time for final intervention and or discharge, the accuracy of initial diagnosis and treatment and the cost-benefit analysis.

Results and discussions: One-stop clinics have been successfully established in a few fields of medicine. One stop breast lump clinic has been running for almost 10 years with a very good reputation of rapid, accurate and cost-effective diagnosis of breast lumps. Similar successful examples have been emerged in gynaecology such as fertility clinic and uterine bleeding clinic; and in urology such as haematuria clinic. To our best knowledge, this is the first study that investigated the one-stop clinic in shoulder problems. Our results showed similar trend of success in term of reduction of patients’ hospital visits, waiting time to treatment and accuracy of the diagnosis. We also conducted a cost-benefit analysis of the one stop shoulder clinic in comparison with the conventional shoulder clinic and we concluded that it is cost effectiveness.


S.K. PAI E. POWELL I.A. TRAIL

Purpose of Study: To compare the mechanical performance of two commonly used arthroscopic slip knots with that of a hand tied control.

Methods: The arthroscopic slip knots assessed were the Duncan Loop (DL) and the Tautline Hitch (TLH), both of which were tied with arthroscopic knot pushers and secured with Three Reversing Hitches on Alternating Posts (RHAPs). These were compared with four hand tied throws of a squre knot. All three knots were tied using three different materials: number two Ethibond, number one PDS and number two Fiberwire. All knots were tied in a close loop configuration between two metal bars mounted on an Instron materials testing device and pulled apart to both clinical and ultimate failure. Clinical failure was defined as the force in Newtons (N) required to increase loop length by three millimetres, which equtes in vivo with a critical loss in apposition of repaired tissues. Ultimate failure was defined as the force in N resulting in complete slippage or breakage of the knot being tested. This study was different than those before it in that a much larger number of each knot/suture permutation was tested (thirty in each case) to give the study sufficient power to detect significant differences between the knots tested.

Results and Conclusion: Based on the findings of this study, it is our recommendation that an arthroscopic TLH slip knot secured with three RHAPs and tied using a number two Fiberwire suture be used to produce shoulder repairs that are equivalent if not superior to those achieved using open hand tied methods.


P Downie A Rajniashokan S Sharma G Tait

Introduction More than 2% of the general population is reported to be affected by adhesive capsulitis. The incidence is greater in patients with diabetes than in the general population for both IDDM and NIDDM. This study sought to test the hypotheses that diabetes does not have an effect on outcome and does not contribute to morbidity.

Materials and methods Data were collected retrospectively by reviewing medical records from 1996 to 2005. A total of 148 case notes were evaluated to identify patients with a diagnosis of frozen shoulder who underwent MUA ± arthroscopy ± release. Twenty-two patients (22 shoulders), 12 of whom had diabetes, agreed to participate and were included. The diabetic and non-diabetic groups were broadly comparable with respect to demographic characteristics. Invited patients were asked to assess current physical function and symptoms by completing a shortened version of the DASH outcome measure questionnaire prior to attending the clinic and a further questionnaire detailing pre-op symptoms. Physical function was assessed and calculated using the Constant score system.

Results The median pre-operative DASH score was 72.73 in the diabetic group and 71.00 in the non-diabetic group (difference 2.3%). The median post-operative DASH score was 27.27 in the diabetic group and 28.86 in the non-diabetic group (difference 5.51%). The median postoperative Constant score was 60.00 in the diabetic group and 59.50 in the non-diabetic group (difference 0.83%).

Conclusion The pre- and post-operative DASH results and post-operative Constant score showed little difference between diabetic and non-diabetic patients. While giving due cognisance to the small number of patients included and the retrospective design of the study, the results support the hypothesis that diabetes does not have an effect on outcome following MUA or arthroscopy for adhesive capsulitis and does not contribute to morbidity.


R Carey Smith G Tytherleigh-Strong

Aim: To characterise the reasons for failure following primary surgical stabilisation in a group of patients considered suitable to undergo revision surgical stabilisation using arthroscopic techniques.

Methods: Patients presenting to our institution following failure of a primary shoulder stabilisation who underwent a revision arthroscopic stabilisation were reviewed. Information about the index procedure, imaging and the findings at arthroscopy were used to characterise the mechanism of failure. Shoulders were assessed pre-op by clinical examination and the WOSI score. At the time of arthroscopy patients proceeded to an appropriate stabilisation procedure using either a suture anchor or a modified transglenoid technique. Shoulders underwent a standard rehabilitation protocol and were reviewed at 6 weeks and then 6 monthly.

Results: Twenty patients underwent a revision arthroscopic stabilisation and were included in the study. Index procedures were arthroscopic stabilisation 4, thermal shrinkage 10 (un-repaired Bankart in 6), open Bankart 2, Putti-Platt 2, unknown procedure 2. Time from index procedure to re-dislocation ranged from 3 months to 7 years. The mechanism of failure was due to soft-tissue problems in all cases and could be grouped into four different categories. Further trauma 4 Inappropriate primary procedure 7 Missed pathology 3 Technical error 6 At early follow up of 6 – 42 months following revision arthroscopic stabilisation 1 patient re-dislocated at 12 months due to further trauma.

Conclusion: Recurrent instability following surgical stabilisation maybe due to soft-tissue failure. Soft-tissue failure can be subdivided into further trauma, inappropriate primary procedure, missed pathology and technical error. Cases within these subdivisions may be suitable for revision surgery using arthroscopic techniques.


TS Waters AM Noorani AA Malone JIL Bayley SM Lambert

We report 5 cases of linked shoulder and elbow replacement (LSER) following failure of single-joint arthroplasty. Whilst total humeral replacement has been reported for treatment following resection for tumour we know of no reports of linked shoulder and elbow prostheses for arthropathy alone. Between May and December 2005, 2 patients with total elbow arthroplasty and 3 patients with total shoulder arthroplasty were revised to LSER for loosening of the long humeral stems or periprosthetic fracture. Custom-made prostheses were produced using computer-aided design and manufacture technology. There were no early complications including infection. All 5 patients reported early improvement of symptoms, with the ability to bear weight axially through the limb, restored. This technique avoids the problem of a stress riser between the stems of separate shoulder and elbow replacements and solves the problem of salvage of long-stemmed implants where no further humeral fixation is possible.


S Patil A Mahon S Green I Mcmurtry A Port

Introduction and aims: There is a recent trend of using a raft of small diameter 3.5 mm cortical screws instead of the large diameter 6.5mm screws in depressed tibial plateau fractures (Schatzker type 3). Our aim was to compare the biomechanical properties of these two constructs in the normal and osteoporotic sawbone model.

Methods: 10 sawbone (solid rigid polyurethane foam) blocks with a density simulating that of an osteoporotic bone and 10 blocks of a density simulating normal bone were obtained. A Schatzker type 3 fracture was created in each block. The fracture fragments were then elevated and supported using 2, 6.5mm cancellous screws in 10 blocks and 4, 3.5mm cortical screws in the remaining.

The models were loaded to failure using a Lloyd’s machine. A displacement (depression) of 5mm was taken to be the point of failure. A load displacement curve was plotted using Nexygen software and the force needed to cause a depression of 5mm was calculated in each block. Mann Whitney U test was used for statistical analysis.

Results: Osteoporotic model

The mean force needed to produce a depression of 5mm was 700.8N with the 4-screw construct and 512.4N with the 2 screw construct. This difference was statistically significant (p=0.007).

Non-osteoporotic model

The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct. The difference was not statistically significant (p=0.42).

An increased fragmentation of the sawbone fragments was noticed with the 2-screw construct but not with the 4-screw construct.

Conclusion: A raft of 4, 3.5 mm cortical screws is biomechanically stronger than 2, 6.5mm cancellous screws in resisting axial compression in osteoporotic bone.


X Chen G Li

Mesenchymal stem cells (MSCs) are immunosuppressive and have been used to facilitate tissue repair in the context of allogeneic implantation. However, xenogeneic cell transplantation has not been fully explored. The present study investigated the feasibility of xenogeneic MSCs implantation in mice.

MSCs were harvested from the bone marrow of GFP rats (Green Fluorescent Protein transgenic rats), and cultured as previously described. 1 million GFP MSCs were loaded onto the synthetic HA/TCP porous Skelite blocks and implanted intramuscularly into the quadriceps of the MF1 and SCID mice. After 11 weeks, the implants were harvested and processed for histology examination. Upon termination, the mononuclear cells from the peripheral blood of each animal were also collected for mixed lymphocyte culture to examine lymphocyte proliferation potential and T-cell mediated cell lysis (cytotoxic) assays.

In the SCID mice, there was sparse osteoid tissue formation in the implants, whereas only dense connective tissues were seen in the implants of the MF1 mice. Osteocalcin mRNA expression was confirmed in the osteoid tissues in the implants from the SCID mice, but it was not detected in the MF1 mice by RT in situ PCR examination. Cells of GFP-rat origin were observed in both the MF1 and SCID mice (more so in the SCID mice) after 11 weeks implantation, which were confirmed by positive immunostaining of anti-GFP antibody. In the MF1 mice after 11 weeks xenogeneic MSCs implantation, the rate of lymphocyte proliferation was significantly increased when mixed with the GFP-MSCs compared to that of mixed lymphocyte culture assays in the SCID or MF1 mice without xenogeneic MSCs implantation, suggesting that implantation of xenoge-neic MSCs has promoted host anti-graft immunogenic responses towards to otherwise immunosuppressive MSCs.

In conclusion, xenogeneic rat MSCs transplanted in immunocompetent mice has survived for prolonged period, but their function was comprised to certain extent and this may be due to the increased host anti-graft immune sensitization after exposed to the xenogeneic MSCs.


M Changulani UK Jain

The aim of this study was to compare the results of humerus intramedullary nail(IMN) and dynamic compression plate DCP) for the management of diaphyseal fractures of humerus.

Material & Methods- 47 patients with diaphyseal fracture of shaft humerus were randomised prospectively and treated by open reduction and internal fixation with IMN or DCP. The criteria for inclusion was Grade 1,2a compound fractures, polytrauma, early failure of conservative treatment, unstable fracture. The patient with pathological fracture, Grade 3 open fracture, refracture, old neglected fracture of humerus were excluded from the study. 23 patients underwent internal fixation by IMN and 24 by DCP. Reamed antegrade nailing was done in all cases. DCP was done through an anterolateral or posterior approach.

Results -The outcome was assessed in terms of functional outcome and the incidence of complications. Functional outcome was assessed using the Americans Shoulder and Elbow Surgeons Score (ASES). On comparing the results, there was no significant difference in ASES score between the two groups. The rate of complications was found to be higher in patients treated with IMN than with DCP. The complications that were encountered with IMN were non union, shortening of the arm, impingement of the shoulder, implant failure. The rate of secondary surgery was also found to be significantly higher with IMN.

Conclusion – There is sufficient evidence to suggest that DCP still remains to be the operative treatment of choice for diaphyseal fractures of humerus. IMN may be indicated only in specific situations like segmental fractures, pathological fratures though this study did not aim to look into that aspect.


RS Tare R Forsey JB Chaudhari ROC Oreffo

Cartilage is a realistic target for tissue engineering given the avascular nature and cellular composition of the tissue. Much of the work in this field has been largely empirical, indicating the need for alternative approaches to the design of cartilage formation protocols. Given the heterogeneity associated with human mesenchymal populations, continuous cell lines may offer an alternative to model and simplify cartilage generation protocols. We therefore exploited the potential of the murine chondrocytic ATDC5 cell line to, i) delineate the process of chondrocyte differentiation in monolayer culture and three-dimensional micromass pellet culture systems, and ii) model cartilage formation utilising appropriate scaffold and bioreactor (perfused and rotating) technologies. Monolayer cultures of ATDC5 cells over a 28-day period in presence of insulin demonstrated various stages of chondrocyte differentiation- proliferative, pre-hypertrophic, hypertrophic and finally, mineralisation of cartilaginous nodules. This was confirmed by gene and protein expression, by qPCR and Western blotting respectively, of chondrogenic differentiation markers- Sox-9, Bcl-2, Type II and X collagens. Pellet cultures of ATDC5 cells under chondrogenic conditions (10 ng/ml TGF-beta3, 1X ITS {insulin, transferrin, selenium}, 10 nanomolar dexamethasone, 100 micromolar ascorbate-2-phosphate) illustrated a gradual progression from an aggregation of cells at day 7, to initiation of matrix synthesis at day 14, followed by formation of well-defined cartilaginous structures at day 21. Chondrogenic differentiation at day 21 was evident by numerous proliferative/ pre-hypertrophic chondrocytes, staining for Sox-9, Aggrecan, Type II collagen and PCNA, lodged in distinct lacunae embedded in cartilaginous matrix of proteogly-cans and Type II collagen. Inclusion of TGF-beta3 in the chondrogenic medium during pellet culture beyond 21 days maintained the pre-hypertrophic phenotype, even at day 28. In contrast, removal of TGF-beta3, addition of 50 nanomolar thyroxine and reduction of dexa-methasone to 1 nanomolar in the chondrogenic medium stimulated hypertrophy at day 28, evident by down-regulation of Sox-9 expression. ATDC5 cells cultured on Polyglycolic acid fleece in the rotating bioreactor or encapsulated in chitosan /alginate and cultured in the perfused bioreactor for 21 days, formed cartilaginous explants reminiscent of hyaline cartilage. Thus, ATDC5 cells constitute an ideal cell line to elucidate the steps of chondrocyte differentiation and cartilage formation.


M Korda G Blunn N Little J Hua

Introduction: The current practice of impaction allograft to fill large defects in revision total hip replacements is sometimes useful but clinical results are inconsistent. Other studies have shown that addition of mesenchymal stem cells (MSC) in blocks of hydroxyapatite (HA) scaffold can enhance new bone formation in a critical sized defect. However, no study has been conducted on combined MSCs with morselised allograft and HA granules. It is hypothesized that impaction of allograft or HA granules seeded with MSCs or osteoprogenitors will enhance new bone formation compared with the groups without MSCs.

Materials and Methods: Six sheep were used for the study. Each sheep received 8 scaffolds which were embedded in both paraspinal muscles. Groups were: 1) 3.5g allograft, 2) 3.5g allograft with MSCs, 3) 3.5g allograft with osteoblasts; 4) 3.5g of 50:50 allograft/ HA, 5) 3.5g of 50:50 allograft/HA with MSCs, 6) 3.5g of 50:50 allograft/HA with osteoblasts; 7) a block of HA, 8) a block of HA with MSCs. The experimental scaffolds were seeded with either 10x106 MSCs/ml or 10x106 MSC-derived osteoprogenitors/ml, in 3ml autologous plasma. Grafts were impacted twenty times at 3KN. At eight weeks, samples were sectioned for histology analysis. Areas of new bone formation were measured as percentage to total available spaces. ANOVA was used for statistical analysis.

Results: Addition of MSCs increased new bone formation in allograft (4.98%), allograft/HA (5.15%) and HA block (7.09%) compared with their controls at 2.24%, 1.96% and 1.96% respectively. Statistical study showed significant increase in 50:50 allograft/HA with MSCs compared with 50:50 allograft/HA only (p=0.046) and 50:50 allograft/HA with osteoprogenitors (p=0.028). No difference was found in allograft groups. For the HA block groups, addition of MSCs showed a significant new bone increase compared to the control (p=0.028).

Conclusion: Addition of MSCs to the allograft and HA granules will enhance new bone formation after impaction which can be used for revision total hip replacements, especially when allograft and HA is mixed. However, addition of osteoprogenitors has not achieved the similar results. This study encourages a further clinical investigation of impaction tissue-engineered graft to repair bone defects in revision total joint replacements.


J P Little DW Murray HS Gill

Hip resurfacing arthroplasty (HRA) is increasingly carried out as an alternative to total hip arthroplasty (THA) in young patients. During the procedure, a metal stem on the retrosurface of the HRA is inserted into the femoral head to ensure the implant is located centrally with respect to the femoral neck. It has been suggested that the stem may interfere with bone loading. In light of this, the current study employed finite element (FE) models to investigate the change in the HRA-implanted bone mechanics as a result of removing the stem. FE models of a cadaveric femur pre- and post-HRA surgery were analysed to determine changes in bone stress/ strain.

The implanted models simulated geometry for a cemented HRA with and without a non-cemented stem (HRA-Stem and HRA-NoStem, respectively) and included more accurate multiple material parameters to simulate the non-homogeneous material distribution in the femoral bone. The models included loading conditions simulating an instant at 10% of the gait cycle. Bone stresses/strains in the femoral head and neck of the implanted models were compared with the intact condition to assess the change in bone mechanics. Changes in cement mantle stresses between the HRA-Stem and HRA-NoStem models were also compared.

When comparing similar volumes of bone in the femoral neck, both HRA models showed a similar variation in stress from the intact condition and bone stresses were low in comparison to the ultimate strength of cortical bone. There was less change in peak strain energy in the femoral head of the HRA-NoStem model than the HRA-Stem model. Cement mantle stresses in the HRA-NoStem model were slightly higher than for the HRA-Stem model and the peak compressive stress was close to the fatigue limit for bone cement.

These preliminary results suggest that the bone loading is more normal without the stem. However, there are increased cement mantle stresses.


E Dunstan D Ladon P Whittingham-Jones S Cannon P Case T Briggs

Background: Metal-on-Metal (MoM) hip bearings are being implanted in ever increasing numbers and into ever-younger patients. The consequence of chronic exposure to metal ions is a cause for concern. Therefore, by using cytogenetic biomarkers, we investigated a group of patients who have had MoM bearings in-situ for in excess of 30 years.

Method: Whole blood specimens were obtained from an historical group of patients who have had MoM bearings in-situ for in excess of 30 years. Blood was also obtained from an age and sex matched control group and from patients with Metal-on-Polyethylene (MoP) components of the same era.

The whole blood was cultured with Pb-Max karyotyping medium and harvested for cytogenetics after 72 h. The 24 colour FISH (Fluorescent In Situ Hybridisation) chromosome painting technique was performed on the freshly prepared slides allowing chromosomal mapping. Each slide was evaluated for chromosomal aberrations (deletions, fragments and translocations) against the normal 46 (22 pairs and two sex) chromosomes. At least 20 metaphases per sample were scored and the number of Aberrations per cell calculated.

Results: Chromosomal aberrations, including deletions, fragments and translocations were only detected in the peripheral blood lymphocytes isolated from the group that had MoM bearings. These changes were not present in the age and sex matched control group. The chromosomal aberrations were also detected in the patients previously exposed to MoM bearings who have been revised to a MoP articulation.

Conclusion: We have detected dramatic chromosomal aberrations in peripheral blood lymphocytes in a group of patients chronically exposed (over 30 years) to elevated metal ions. It is not known whether these aberrations have clinical consequences or whether they are reproduced in other cells in the body. The results emphasise the need for further investigations into the effect of chronic exposure to elevated metal ions produced by Orthopaedic implants.


SN Racey JL Tremoleda D Wojtacha N Khan J McWhir AHRW Simpson BS Noble

We have used human Embryonic Stem cells (hESC) and human Mesenchymal Stem Cells (hMSC) in rat models of bone repair in order to assess the efficacy of these cells for treatments of trauma and skeletal diseases. Graft survival is considered to be of key importance to efficacy of these treatments. Therefore the aim of this study was to develop a technique for identifying implanted cells in histological preparations without the need for genetic engineering of the implanted cells.

Methods: In our experiments hES and hMSC were pre-differentiated during cell culture towards the osteoblast lineage, and then implanted in a Demineralised Bone Matrix (DBM) carrier into an experimentally created full thickness calvarial bone lesion. The animals were sampled seven days and fourteen days after implantation into either immune deficient (RNU-Foxn1rnu) or immune competent (wild type) Sprague Dawley rats. Fluorescent In Situ Hybridisation (FISH) using whole human genome probes identified the human cells within the host lesion site.

Results: Our results have demonstrated that hESC and hMSC derived cells survive in both immune competent (wild type) and immune compromised (nude) animals for the initial seven days post implantation. On the other hand while both the hESC and hMSC derived cells are capable of surviving for at least 14 days in immune compromised animals they do not survive for this period of time in immune competent animals.

Discussion: It appears that the cell/DBM graft is not rejected within seven days even when exposed to the wild type hosts T cell response. However longer term survival required an immune deficient model that is lacking in a T cell response. This data points to interesting future studies regarding which components of the host response are responsible for xenogenic stem cell implant rejection.


M Khan D Derham M Waseem

We present a unique prospective study which estimates the median sustained stage related improvement in pain and hand function predicting symptomatic relief period with high accuracy with a single steroid injection.

Patients were grouped into stages, I to IV according to the Eaton and Glickel radiological criteria. The steroid injection contained 40mg triamcelone and 1% lido-caine. The response was assessed by DASH and a visual analogue score before and at six-week interval. We used the Kaplan-Meier method to estimate median length of sustained improvement by grade of disease, with 95% confidence interval. All the patients were injected by an upperlimb physiotherapist (DD). Post injection review was carried out by an independent observer(MK).

Forty patients were studied: 33 females and 7 males. The age ranged from 53 to 81 years, (mean 65years). No patient was lost to follow-up. Mean duration of symptoms were 36 months. Six patients has stage I disease(15%), eighteen patients had stage II disease (45%), ten patients had stage III disease (25%) and six patients has stage IV disease (15%). Pain score ranged from 4 to 9 on visual analogue score. Reduction in pain visual analogue score was noticed in all but 3 patients. With the exception of Grade III patients, DASH scores decreased significantly at 6 weeks (Grade I 14.9, Grade II 19.3, Grade III 6.2 and Grade IV 10.0.). With the exception of Grade IV patients, pain scores decreased significantly at 6 weeks. In Grade II patients, over half had sustained symptomatic relief at 6 months. So on average, we can expect grade I patients to sustain symptomatic relief for an average of 17 weeks. The true average is likely to be between 13 and 21 weeks. For grade II patients, most will still have improved at 6 months. Grade III and IV patients have an identical prognosis of 4 weeks, though the true prognosis may be between 2 and 6 weeks.

In conclusion it is possible to predict the period of symptomatic improvement in each of the four disease stages. This allows the treating clinician to discuss the outcome of treatment with reasonable accuracy.


IDM Brown IG Kelly Prof IB McInnes

In patients with DM (Diabetes Mellitus types I & II), primary frozen shoulders tend to be refractory to all forms of treatment. We collected tissue from the joint capsule of shoulder joints from a variety of patients undergoing surgery as follows:

Diabetic Group (DFS): patients with DM who have primary frozen shoulders.

Other patients suffering from primary frozen shoulders (FS)

Control group (NS). Patients undergoing shoulder surgery that does not involve stiffness of the gleno-humeral joint.

Tissue was collected from near to the rotator interval under arthroscopic control. Fibroblast lines were established by serial passage. Thereafter they were exposed to graded concentrations of insulin in vitro for 24 hours and the supernatant retained for assay. Fibroblast lines were analysed from 3 subjects in each group (n=9). Luminex multiplex analysis was performed for MMPs (Matrix Metalloproteinases). TIMP-1 (Tissue Inhibitor of MetalloProteinases) expression. Informed consent was obtained from all subjects.

Results: Production of MMP 1,2,3 and 8 by fibroblast lines were distinct between patient groups. MMP-1 production in DFS (mean 716pg/mL) was significantly reduced compared to FS derived patient cells (mean 972pg/mL) (p=0.0138, Mann-Whitney Test). Moreover, striking differences were observed when fibroblasts from DFS patients were compared with those from NS controls (mean 5898pg/mL) (p< 0.000). Calculating MMP-1/TIMP-1 ratios revealed significantly lower ratios in DFS (2597), or FS (2860) compared with NS (24,326) (p < 0.001). There was no significant difference between ratios of MMP1/TIMP1 in DFS and FS (p=0.977). MMPs 7,9,12 and 13 were not detected in any of the samples.

This is the first time these enzymes have been measured and quantified in cells derived from shoulder tissues. Primary Frozen Shoulders produce less MMPs and have a smaller MMP/TIMP ratio than controls. Similarly the diabetic patient derived cells produce less MMP-1, at an even lower level. These deficiencies in MMP1 production may reflect an altered capacity for local tissue re-modelling. MMP modulation may allow therapeutic intervention in the diabetic and frozen shoulder group of patients.


XQ Hu A Taylor M Tuke

The clearance between the femoral head and the acetabular cup can significantly affect the lubrication, the wear and the lifetime of metal on metal (MOM) hip joints. The objective of this study was to compare the frictional behaviour of MOM joints with different clearance.

Two CoCrMo MOM 50mm diameter hip joints, with a small diametral clearance of 17 microns and a big diametral clearance of 212 microns, were used in this study. The friction measurement was carried on the wear patches of MOM bearings during a long-term wear simulator test. A dynamic trapezoidal-form loading cycle was applied to the femoral head with a minimum load of 100N during the swing phase and a maximum load of 2000N throughout the stance phase. A simple harmonic motion of amplitude +/−24 degree was applied to the femoral head in the flexion-extension plane with a frequency of 1 Hz. The friction torque was measured at 0, 0.8, 1.3, 1.9, 4 and 5.5 million cycles using 6 different viscosities of 25% new born calf serum.

The results show that the friction factors (f) of small clearance were generally higher than those of big clearance and this difference became wider with the progress of wear. The lower f of big clearance, especially in the lower range of Sommerfeld number (z) after 5.5 million cycles, is significant and will affect the ultimate performance of prostheses as this range has closer rheological properties to synovial fluid and represents long term wear conditions. At the same time, the friction factors were always higher every time when measured from high z to low z, although this difference became slightly smaller with the progress of wear, which indicates that there is still direct contact between the bearings. The lower friction factor when increasing z, is due to the wear and bedding-in with the progress of the measurement. It is concluded that large clearance has lower friction factor than small clearance, and full fluid film lubrication is unlikely to have developed between the MOM bearings in this study, even with a small clearance and high viscosity.


MA Suarez-Suarez M Alvarez-Rico F Ferrero-Manzanal P Menendez-Rodriguez A Meana-Infiesta J deCos-Juez JC deVicente-Rodriguez A Murcia-Mazon

Background and objective: In guided tissue regeneration a membrane is used for defect isolation to protect it against invasion from surrounding tissues and to keep intrinsic healing factors ‘in situ’. This technique has been successfully used in maxillo-facial surgery, but short experience has been reported in long-bone defects, with synthetic membranes and with variable results. In the other hand, calcification and ossification inside the arterial wall have been described. The aim of the study was to evaluate the use of cryopreserved aorta allografts as membranes for guided tissue regeneration in comparison with expanded poly-tetra-fluoro-ethylene (e-PTFE) synthetic membranes.

Methods: Prospective, randomized, blinded study in 15 New-Zeland rabbits. 10 mm mid-diaphyseal defects were created in both radii: 10 defects were covered with a cryopreserved aortic allograft as a tube, 10 with an e-PTFE membrane and 10, with no barrier membrane, served as controls. Animals sacrifice at 6-12-24-30 months. Studies: X-rays, CT, MR, morpho-densitometric analysis, electronic and optical microscopy. Immuno-cytochemistry on tissues and arterial wall cells cultured.

Results: None of the control defects healed. Nine defects covered with an artery completely reconstituted, but only six of those covered with e-PTFE, with a nearly normal cortical-medullar pattern and with progressive increasing in density and thickness of medullar and cortical to values similar to those of the normal bone. Histological studies showed no inflammatory response to the arterial graft, direct union between the artery and the regenerated bone and even mature bone between the elastic laminae of the arterial wall, suggesting superior biocompatibility properties. Immuno-cytochemistry and ultrastructural studies suggest that arterial allografts could act not only as membrane barriers, with additional osteoinductive properties due to trans-differentiation of viable arterial wall cells (endothelial, smooth muscle and/or tissue specific stem cells) towards osteoblastic cells, and also due to ossification secondary to changes in proteins of the arterial extracellular matrix. This could be the application of the process of arterial wall calcification and ossification (usually seen in arteriosclerosis, gender, diabetes or kidney failure) for regeneration of long-bone defects.

Conclusion: Cryopreserved aortic allografts can be used as membrane barriers for guided bone regeneration, with superior results to e-PTFE membranes.


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M Bains S Lambert V Mudera

The purpose of the study was to test the hypothesis that cellular mechanisms of fibroblasts derived from primary frozen shoulder(PFS) exhibit similar activity in terms of contraction, response to cytokine (transforming growth factor-beta1) and mechanical stimulation similar to that generated by fibroblasts derived from dupuytren’s disease. PFS is a debilitating disease of unknown aetiology, characterised by fibrosis with contracture of the cora-cohumeral ligament, tissues of the rotator interval and glenohumeral ligaments, leading to restrictive shoulder movements. Frozen shoulder has been postulated to be Dupuytren’s disease of the shoulder with an association inferred since 1936.

Materials and Methods: Primary explant cultures of fibroblasts from seven patients with PFS and five control patients were obtained using standard tissue culture techniques. Fibroblasts were seeded in 3-D collagen constructs and contraction force generated over 24hours measured using a culture force monitor(CFM) in real time. Increasing concentrations of TGF-beta1 were added to cell seeded gels and force generated measured using the CFM over 24hours. These mechanical output data were statistically compared to data available from Dupuytren’s disease.

Results and Discussion: Compared to Dupuytren’s fibroblasts, PFS fibroblasts showed a statistically reduced ability to contract a 3-D collagen gel over 24hours (p< 0.01). In Dupuytren’s disease, fibroblasts derived from nodules and cords generate peak forces of 140dynes and 110dynes respectively, while PFS fibro-blasts generated peak force of 8dynes The response to TGF-beta1 stimulation, which has been shown to enhance peak force contraction in Dupuytren’s fibro-blasts had no effect on PFS fibroblasts and this was statistically significant (p< 0.01).

Conclusion: These data suggest intrinsic differences in cellular activity and mechanisms between Dupuytren’s and Primary Frozen Shoulder even though clinically they both manifest with a contracted extracellular matrix affecting function and requiring surgical intervention. This may explain increasing post surgically recurrence in Dupuytren’s as compared to Primary Frozen Shoulder release.


MS Gaston BS Noble AHRW Simpson

An estimated 10% of patients have problems with fracture healing. Initial studies have revealed that it is likely that both the innate and specific immune systems play a role in fracture repair, but this has not been attributed to particular components, cells or their products. It is known that the functionality of the immune system is impaired with age and this may account for the higher rate of delayed union in elderly patients.

We used a validated mouse model of a reproducible closed tibial fracture. In order to prevent any foreign body inflammatory/immune response no artificial internal fracture fixation was used and instead external support was provided using a Plaster of Paris cast. The role of the specific immune system was studied using an immunodeficient Balb/c SCID (Severe Combined Immuno Deficient) mutant mouse. The SCID mice were matched for age, sex (all males) and weight to the control, wild type Balb/c mice. Mechanical (4 point bending) and radiographic (Radiographs scanned and calculations of callus area, index and density made with image analysis software) measures were used to assess fracture repair at 21 days.

Mechanical measurements revealed an enhancement of fracture healing in the SCID mouse strain compared to the control strain, with stress at yield and Young’s modulus higher in SCID mice than controls. (Stress at yield: 4.2 +/− 0.23MPa in Controls, 7.1 =/− 0.6MPa in SCIDs, P< 0.01; Young’ Modulus: 22.1 +/− 2.99MPa in Controls, 60+/− 9.9MPa in SCIDs P< 0.01). There were no significant differences seen in mechanical properties of unfractured bone between the two strains. Radiographic analysis revealed no significant differences in callus area or index (both measurements of callus size) but callus density was significantly higher (P< 0.01) in the SCID subjects compared to controls (2.6 +/− 0.06E5 Greyscale in SCIDs vs. 2.2 +/− 0.09E5 in controls).

We conclude that an abnormality of the immune system due to either lack of the specific immune system (T and B cells) or an enhancement of the innate system results in increased mineralization, stiffness and strength of fracture healing, and that further investigation might result in novel therapies directed toward avoidance of non/delayed-union.


SJ Flood R Parri A Williams VC Duance DJ Mason

Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 350,000 people in the UK. Within synovial joints, synoviocytes form a destructive pannus that degrades articular cartilage and bone. Synovial fluid glutamate levels increase 54 fold in RA patients and are also elevated in animal models of inflammatory and osteoarthritis. To determine whether elevated glutamate levels contribute to RA pathology we investigated which synovial joint tissues express glutamate receptors and whether glutamate stimulation influences synovio-cyte phenotype.

Various glutamate receptor mRNAs (NMDAR1, KA1, AMPAGluR2, AMPA GluR3, mGluR4) were expressed in tissues of the rat knee. All receptors were expressed in the patella. The fibrocartilagenous menis-cus and articular cartilage chondrocytes expressed mGluR4 and both AMPA receptor subunits. Human synoviocytes expressed NMDAR1 and KA1 mRNA.

To determine whether glutamate receptors were functional in human synoviocytes, cells were preloaded with a fluorescent indicator of intracellular calcium (iCa 2+) and stimulated with glutamate or specific agonists (NMDA or kainate, 500mM). Glutamate stimulated release of iCa2+ in 25% of synoviocytes whereas NMDA and Kainate each stimulated 15% of cells. NMDA responses increased to 57% in the absence of Mg2+ consistent with the inhibitory effect of Mg2+ on this receptor.

To determine whether activation of glutamate receptors can influence human synoviocyte phenotype, we cultured synoviocytes in various glutamate concentrations (50mM to 2mM) and measured effects of glutamate receptor antagonists on release of a proinflammatory cytokine (IL-6) and degradative enzymes (MMP2 and 9). In some RA patients, glutamate stimulation increased synoviocyte pro MMP-2 release. TIMP1 and TIMP2 release were not affected by glutamate stimulation or co-treatment with receptor antagonists.

IL-6 expression varied greatly in human synoviocytes derived from different RA patients (0–120pg/ml media). However, the AMPA/KA receptor antagonist NBQX significantly reduced IL-6 release at all glutamate concentrations. This inhibition was greater than that by CFM2 (AMPAR antagonist), indicating that activation of kainate receptors in human synoviocytes may induce IL-6 release.

We conclude that glutamate receptors are functional in human synoviocytes and regulate release of MMP-2 and IL-6 Thus glutamatergic signalling may contribute to RA pathology and represent a new therapeutic target.


K Hashimoto N Yamada S Kokubun HI Roach

Osteoarthritis (OA) is characterized by progressive erosion of articular cartilage due to degradation of the cartilage matrix. The major enzymes involved are the matrix metalloproteases and aggrecanases, which are either derived from the synovium or synthesized by chondrocytes as OA progresses. This abnormal enzyme synthesis is part of a phenotypic change from normal to ‘degradative’ chondrocytes. If this change could be prevented, then disease progression might be slowed.

In early OA, degradative chondrocytes are only present in the superficial zone, but with increasing severity of OA, more chondrocytes become degradative cells so that, in high-grade OA, these cells are also located in the deep zone. We hypothesized the existence of a ‘factor X’, which diffuses from the superficial to the deep zone and induces cells to change phenotype and express the pro-teases. We further hypothesize that this factor is released by degradative chondrocytes. To test the hypothesis, we co-cultured explants of human superficial-zone OA cartilage (which contains degradative cells and thus factor X) with explants of deep-zone cartilage from fracture neck of femur patients (#NOF), which contains mostly normal chondrocytes that do not express the proteases. We investigated MMP expression by real time RT-PCR and protein synthesis by immunohistochemistry.

Before culture, MMP-2, -3, -9, or -13 were expressed in the superficial-zone OA cartilage, but not in deep-zone #NOF cartilage, as expected. After 4 weeks with separate culture of superficial zones and deep zones, no MMPs was expressed in deep zone chondrocytes, suggesting that culture per se did not induce expression of these enzymes. Neither did culture abolish expression in the superficial zone, as confirmed by RT-PCR and immunohistochemistry. However, when superficial-zone cartilage was co-cultured with deep-zone cartilage, MMP-3 expression were induced in deep- zone chon-drocytes, suggesting that a diffusible factor X, derived from degradative chondrocytes, had induced normal articular chondrocytes to express MMP-3. These experiments provide evidence for the existence of a factor that, when diffusing through the cartilage matrix, has the potential to induce normal non-enzyme expressing cells to become degradative chondrocytes.


P Pollintine D Skrzypiec P Dolan MA Adams

Introduction: The cervical spine can be severely loaded in bending during sporting injuries and ‘whiplash’. Compressive loading could also be high if some advanced warning of impact stimulated vigorous (‘protective’) contraction of the neck muscles. Combined bending and compression can cause some lumbar discs to herniate in-vitro (1) but the outcome depends on spinal level, and may not be applicable to cervical discs. We test the hypotheses: a) that cervical discs can prolapse in-vitro, and b) that prolapse leads to irregular stress distributions inside the disc.

Material and methods: Human cervical ‘motion segments’ (two vertebrae and intervening soft tissues) were obtained from cadavers aged 51–88yrs. Specimens were secured in cups of dental stone and subjected to static compressive loading (150N) for 20s. During this time, the distribution of vertically-acting compressive ‘stress’ was recorded along the postero-anterior diameter of the disc by pulling a 0.9mm-diameter pressure transducer through it (2). Injury was induced by compressing each specimen at 1mm/s while positioned in 20 deg of flexion, 15 deg of extension, or 8 deg of lateral bending. The distribution of compressive stress within the disc was then re-measured. Specimens were sectioned at 2mm intervals in order to ascertain soft tissue disruption.

Results: In all six specimens tested to date, one or both of the apophyseal joint capsules were ruptured by the complex loading. Intervertebral disc prolapse also occurred in all six specimens, with the herniated nucleus appearing on the anterior, posterior and postero-lateral disc surface in extension, flexion and lateral bending respectively. All modes of failure affected intradiscal stresses: on average, nucleus pressure decreased by 75% (STD 7%), while stress concentrations in the annulus increased by 130% (STD 21%).

Discussion: These preliminary results confirm that severe complex loading can cause cervical discs to prolapse. No particular state of disc degeneration is required, provided the loading is sufficiently severe. Indeed, the altered stress distributions suggest that cell-mediated changes would probably follow prolapse.


AP Rumian ERC Draper AL Wallace AE Goodship

The skeletal system exhibits functional adaptation. For bone the mechanotransduction mechanisms have been well elucidated; in contrast, the response of tendon to its mechanical environment is much more poorly understood despite tendon disorders being commonly encountered in clinical practice. This study presents a novel approach to developing an isolated tendon system in vivo. This model is used to test the hypothesis that stress-shielding, and subsequent restressing, causes significant biomechanical changes. We propose a control mechanism that governs this process.

A custom-built external fixator was used to functionally isolate the ovine patellar tendon(PT). In group 1 animals(n=5) the right PT was stress-shielded for 6 weeks. This was achieved by drawing the patella towards the tibial tubercle, thus slackening the PT. In group 2 (n=5) the PT was stress-shielded for 6 weeks. The external fixator was then removed and the PT physiologically loaded for a further 6 weeks. In each case, the PT subsequently underwent tensile testing and measurement of length(L) and cross-sectional area(CSA). The untreated left PTs acted as controls (n=10).

6 weeks of stress-shielding significantly decreased material and structural properties of tendon compared to controls (elastic modulus(E) 76.2%, ultimate tensile strength(UTS) 69.3%, stiffness(S) 79.2%, ultimate load(UL) 68.5%, strain energy(SE) 60.7%; p< 0.05). Ultimate strain(US), L and CSA were not significantly changed. 6 weeks of subsequent functional loading (Group 2) caused some improvement in material properties, but greater recovery in structural properties (E 79.8%, UTS 91.8%, S 96.7%, UL 92.7%, SE 96.5%). CSA was significantly greater than Group 1 tendons at 114% of control value.

Previous models of tendon remodelling have relied on either joint immobilization or direct surgical procedures. This model allows close control of the tendon’s mechanical environment whilst allowing normal joint movement and avoiding surgical insult to the tendon itself. The hypothesis that stress-shielding, and subsequent restressing, causes significant biomechanical changes has been upheld. We propose that the biomechanical changes observed are governed by a strain homeostasis feedback mechanism.


F Li JH Kuiper SA Khan C Hutchinson CE Evans

The Ilizarov technique of distraction osteogenesis is becoming a more common way of treating complicated fractures. It has been shown that shear IFMs will delay bone healing whilst axial IFMs are beneficial to the bone healing. Therefore to measure IFMs in conditions of mobility will provide critical information for research and clinic diagnosis. Such data are not provided by static measurements. Traditionally the IFMs were measured by implanting transducers to the bone or using radiological methods. However, these methods are not suitable for either clinic utilization or measurement of IFMS when patients are doing movements which simulate their daily activities. We have designed a dynamic IFMs measuring device.

It includes a displacement transducer array, which is connected to the Ilizarov wires. This transducer array consists of 6 parallel linear displacement transducers, each of which is attached to the fixing wires of the fix-ator. This arrangement of transducers can fit into the configuration of Stewart Platform. The Reverse Stewart Platform algorithm was employed to calculate IFMs. Without measuring the bone fracture segments directly, the two segments were fitted into two planes virtually. By studying the relative movements of the two virtual planes, the algorithm transfers the relative movement to relative axial & shear translation, and relative bending & torsion rotation, between the two fracture segments. Wireless interface was used to transfer the displacement readings from the transducer array to the computer. This setup allows patient perform activities which represent their routine activities.

In laboratory studies, we found the error of this system to be related to the IFMs. For small movements around 100 micron, the absolute error was 50 micron, whereas for larger movements around 1 mm, the error was within 0.22mm.

This real time monitoring method will allow kinematical and kinetic studies on fracture patients treated with Ilizarov frame. Measurements obtained using this novel device will reflect the natural pattern of IFMs during the patients’ daily life. Since use of the device requires no additional pin, wire or operative procedure, it will be clinically applicable. The accurate real-time IFMs measurements will help elucidate the complex interplay between movement and bone formation.


E Ross TJ MacGillivray H Simpson WN McDicken

Imaging of the musculoskeletal system is vital for delivering optimum treatment particularly in the assessment of fracture healing. X-ray and CT are adequate imaging methods for bone but, soft tissue needs other modalities such as MRI and Ultrasound. We propose the use of Freehand 3D Ultrasound to study the early stages of fracture healing by imaging the bone surfaces around the fracture site and monitoring changes in the surrounding soft tissue.

Freehand 3D ultrasound is acquired by attaching a position sensor to the probe of a conventional 2D diagnostic ultrasound machine. As the probe is moved, its position and orientation are recorded along with the 2D ultrasound images. This enables slices through the body to be viewed that would be inaccessible using a normal ultrasound system. Bone surfaces around a fracture site are scanned and the data reconstructed using the Stradx and Stradwin software developed by Cambridge University, to give a 3D visualization of the area.

To assess the feasibility of this proposed method the lower limbs of healthy volunteers were scanned using a 5–10MHz ultrasound probe. The scanning resolution of the system was evaluated using a phantom to ensure millimetre detail could be detected as would be required for imaging early fracture healing. It was found that detail down to 0.8mm could easily be resolved for measurement.

The 3D system could accurately profile the different soft tissue interfaces. The visible surfaces of the tibia were reconstructed to give 3D models. Additional layers of soft tissue interfaces could easily be added to these models to provide more detail.

This imaging modality can provided detailed 3D models of bone the bone surface and surrounding soft tissue. As ultrasound is non-ionizing, rescanning can be conducted more frequently than with CT or x-ray thus offering a more accurate assessment of a patient’s response to healing.


J Luo D Skrzypiec P Pollintine MA Adams DJ Annesley-Williams P Dolan

Introduction: We have shown that vertebroplasty increases stiffness and partly restores normal load-sharing in the human spine following vertebral fracture. The present study investigated how this restorative action is influenced by type of cement injected, bone mineral density (BMD), and fracture severity.

Methods: Fifteen pairs of thoracolumbar motion-segments (51–91 yrs) were loaded on a hydraulic materials testing machine to induce vertebral fracture. One from each pair underwent vertebroplasty with polymethyl-methacrylate (PMMA) cement, the other with a biologically- active resin (Cortoss). Specimens were then creep loaded at 1.0kN for 2 hours. At each stage of the experiment, bending and compressive stiffness were measured, and ‘stress’ profiles were obtained by pulling a pressure-sensitive needle through the disc whilst under 1.5kN load. Profiles indicated the intradiscal pressure (IDP) and neural arch compressive load (FN). BMD was measured using dual photon X-ray absorptiometry. Severity of fracture was quantified from height loss. Changes were compared using repeated measures ANOVA.

Results: Fracture reduced bending and compressive stiffness by 31% and 41% respectively (p< 0.0001), and IDP by 43%–62%, depending upon posture (p< 0.001). In contrast, FN increased from 14% to 37% of the applied load in flexion, and from 39% to 61% in extension (p< 0.001). Following vertebroplasty, these effects were significantly reversed, and in most cases persisted after creep-loading. No differences were observed between PMMA- and Cortoss-injected specimens. The decrease in IDP and increase in FN after fracture were correlated with BMD in flexion and with height loss in extension (p< 0.01). After vertebroplasty, restoration of IDP and FN in flexion were correlated with their loss after fracture (p< 0.01). The former was also related to BMD (p< 0.05).

Conclusions: Changes in spinal load-sharing following fracture were partially restored by vertebroplasty, and this effect was independent of cement type. The effects of fracture and vertebroplasty on spinal load-sharing were influenced by severity of fracture, and by BMD.

These findings suggest that people with more severe fractures and low BMD may gain most mechanical benefit from vertebroplasty.


G Li C Wan H Wang DH Carney JT Ryaby

The thrombin-related peptide, TP508, a synthetic 23 amino acid peptide, has been shown to promote soft tissue, cartilage and fracture repair. We have previously demonstrated that two injections of TP508 have signifi-cantly enhanced bone consolidation in a rabbit model of distraction osteogenesis. This study was to test if a single injection of TP508 in a slow-releasing preparation will have the similar effects.

Unilateral tibial osteoectomies were stabilized with M100 Orthofix lengtheners in 17 male adult NZW rabbits. After 7 days, lengthening was initiated at a rate of 1.4 mm/day for 6 days. The following treatments were given: Group 1: TP508 in saline (300ug/300ul, n=6) was injected into the osteotomy gap at day of surgery and into the lengthening gap at end of lengthening. Group 2 (Control): Dextran gel (300ul, n=6) and Group 3: 300ul Dextran gel mixed with microspheres containing 300ug TP508 (n=5), was injected into the lengthening gap at end of lengthening. All animals were terminated 2 weeks after lengthening. Bone formation was assessed by weekly radiography and the specimens were subject to pQCT, microCT and histology examinations.

On radiographies there was more bone formation in the TP508 treated groups than that of the control group at 1st week post-lengthening and complete union was seen in 50% rabbits in Group 1, 33% in Group 2, and 60% in Group 3 at termination. The mean BMD of the regenerates was significantly higher in the TP508 treated groups than that of the control group (p< 0.05). MicroCT analysis demonstrated advanced bone formation in the TP508 treated animals. For histology, the regenerates were mainly consisted of woven bone of neocortilization and callus remodelling in Groups 1 and 3, whereas in Group 2, focal defects with cartilaginous tissues were frequently seen.

In conclusion we have demonstrated that a single injection of TP508 in the form of slow releasing micro-spheres has enhanced bone consolidation during distraction osteogenesis. TP508 may therefore be applied in the slow-releasing preparation for augmenting bone formation at reduced doses, costs and risks of infections through repeated injections.


G Kirmizidis MA Birch

One way to improve orthopaedic materials is to understand the exact architectural parameters that influence bone cell behaviour. In this study substrates with highly controlled surface features were created using photo-lithographic processes. These surfaces were contrasted for their ability to influence osteoblast activity and inter-cellular communication.

An etched silicon wafer was created by photolithography and used to hot-emboss grooved substrates (10-30micrometers wide/ 5-16micrometers deep) in poly-carbonate (PC). Smaller features were created on polydimethylsiloxane (PDMS) by casting over a photo-resist patterned silicon wafer. Rat osteoblasts were routinely cultured on flat or micro-fabricated substrates or in media supplemented with osteogenic stimuli for 35 days. Alkaline phosphatase activity was colourimetri-cally localised, and mineralised matrix visualised with Von Kossa staining. Connexin-43 was immunolocalised with a CY-2 conjugated antibody. Intracellular communication was studied using a dye (Lucifer yellow) transfer technique and fluorescence microscopy.

Osteoblasts were aligned on the grooved surface. In 10micrometers grooves, cells were in single rows while at 30micrometers the rows were two/three cells wide. Culture of osteoblasts on these surfaces under osteogenic conditions demonstrated alkaline phosphatase activity comparable to flat surfaces but after 28-35 days there was little evidence of bone-like nodules on the grooved substrates. We hypothesized that on grooved substrates cell:cell communication is compromised thus gap-junctions were studied. Image analysis showed that there was lower connexin-43 expression in cells on grooved substrates and fewer discrete gap junction complexes compared to flat surfaces (p< 0.05 ANOVA.). There were also differences between the grooves with con-nexin-43 most abundant on the widest (30micrometers) and deepest grooves (16micrometers). Analysis of dye transfer demonstrated that whilst cell:cell coupling was maintained within grooves it was reduced at the boundaries of the groove. A surface of asymmetric arrays of micro-columns (diameter 5micrometers) was fabricated to retain lateral interactions between osteoblasts whilst still aligning cells. Osteoblast differentiation now resulted in the formation of numerous bone-like nodules and matrix was aligned in the direction of the shortest column distances.

Maintaining appropriate cell:cell communication structures is pivotal in the process of osteoblast differentiation and the design of novel biomaterial surfaces should ensure that cells can maintain these critical interactions.


P Johnston AJ Chojnowski RK Davidson GP Riley ST Donell IM Clark

The matrix metalloproteinases (MMPs) and ADAMTSs (a disintegrin and metalloproteinase with thrombos-pontin motif) are related enzymes collectively responsible for turnover of the extracellular matrix. The balance between the proteolytic action of the MMPs and ADAMTSs, and their inhibition by the tissue inhibitors of metalloproteinases (TIMPs), underpins many pathological processes. Deviation in favour of proteolysis is seen in e.g. invasive carcinoma, whereas an imbalance towards inhibition causes e.g. fibrosis.

Dupuytren’s Disease (DD) is a fibroproliferative disorder affecting the palmar fascia, leading to contractures. A group of patients with end-stage gastric carcinoma were treated with a broad spectrum MMP inhibitor in an attempt to reduce the rate of tumour advancement: a proportion developed a ‘musculoskeletal syndrome’ resembling DD. Several groups have looked at subsets of the metalloproteinase family in relation to DD, but to date, a study of the gene expression of all of the members has not been published. We therefore set out to profile the mRNA expression for the 23 known MMPs, 4 TIMPs & 19 ADAMTSs in DD and normal palmar fascia.

Tissue samples were obtained from patients undergoing surgery to correct contractures caused by DD and from healthy controls undergoing carpal tunnel decompression. The DD tissue was separated macroscopically into cord and nodule. Total RNA was extracted and mRNA expression analysed by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR), normalised to 18S rRNA. Comparing across all genes, the DD nodule, DD cord and normal palmar fascia samples each had a distinct mRNA expression profile. Statistically significant (p< 0.05) differences in mRNA expression included: higher MMP-2, -7 and ADAMTS-3 levels in both cord and nodule; higher MMP-1, -14, TIMP-1 and ADAMTS-4 and -5 in nodule alone, lower MMP-3 in nodule and cord and lower TIMP-2, -3 and -4 and ADAMTS-1 and -8 levels in nodule alone.

The distinct mRNA profile of each group suggests differences in extracellular proteolytic activity which may underlie the process of fascial remodelling in DD. Further in vitro experiments are planned based on these observed differences in gene expression.


V Mann G Kogianni C Huber A Voultsiadou AHRW Simpson DB Jones BS Noble

Physical activity is a key determinant of bone mass and health, however during adulthood and ageing there appears to be a decrease in the ability to respond positively to exercise which is variable between individuals. While exercise is known to protect against the osteopo-rotic process with modest increases in BMD the exact cellular and molecular responses are poorly understood.

We have studied the effect of mechanical stimulation on bone histomorphometric parameters, osteocyte viability and gene expression in human trabecular bone maintained in a 3D bioreactor.

Trabecular bone cores were prepared from femoral head tissue removed from patients undergoing total hip arthroplasty and maintained in the bioreactor system for 3 (n= 4 patients), 7 (n=5 patients) or 28 days (n=1 patient). Cores (n=3 per patient) were either frozen directly on preparation (T0), placed in the bioreactor system and subjected to Mechanical stimulation (3000 μstrain in jumping exercise waveform repeated at 1Hz for 5 minutes daily) or maintained in the bioreactor system with no mechanical stimulation as control. After the experimental period total cell numbers, cell viability and apoptosis were determined in un-decalcified cryosections at specific distances throughout the bone cores by nuclear staining (DAPI), lactate dehydrogenase activity (LDH) and Nick Translation Assay respectively. Consecutive sections were collected and RNA extracted for gene expression analysis.

Mechanical stimulation was shown to increase Bone Formation Rate (BFR) as determined by Calcein label/ distance to bone surface in the 28 day experiment (BFR mcm/day Control 0.01 ± 0.0035 vs Load 0.055 ± 0.0036 p=0.0022). Expression of bone formation markers such as Alkaline Phosphatase and Collagen Type I was shown to increase in all patients however there was an individual variation in the response of Osteopontin to mechanical stimulation as determined by quantitative real time PCR expression analysis. Numbers of viable osteocytes at T0 varied between individual patients however viability was significantly increased and apoptosis decreased in association with mechanical stimulation compared to control in all patient samples examined (p to 0.021). Our data tend to support animal model findings relating to the osteocyte saving effects of exercise and provide an insight into the molecular detail of the exercise response in human bone.


TN Board P Rooney PR Kay

Bone morphogenic proteins (BMPs) are members of the transforming growth factor beta (TGF-beta) family and play a central role in bone formation. These morpho-gens are known to be present in bone matrix however the characteristics of their release during the grafting process has not previously been defined. The aim of this study was to determine the release BMP-7 (osteogenic protein; OP-1) from cancellous allograft that occurs during impaction grafting for revision hip arthroplasty.

Forty, 10mm cubes of cancellous bone were accurately cut from the central region of 7 fresh frozen femoral heads. The cubes were centrifuged and washed to remove the marrow contents. The cubes were then individually washed and the fluid assayed for BMP-7 activity using a commercially available enzyme linked immuno-sorbent assay kit (Raybiotech Inc.). The cubes were then divided into 4 groups with samples from each femoral head in each group. Each group was subjected to strain of either 20%, 40%, 60% or 80% using a material testing machine. The cubes were then individually washed again and the wash fluid analysed for BMP-7 activity.

BMP-7 activity was found to be present in all groups. Release of BMP-7 was found to increase with increasing strain. At 80% strain the mean concentration of BMP-7 released (830 pg/g) was 58% greater than that released at 60% strain (527 pg/g), 150% greater than the concentration at 40% strain (333 pg/g) and 476% greater than at 20% strain (144 pg/g). The differences between release at 80% and 40% strain and between 80% and 20% strain were statistically significant (p=0.036, p=0.002).

Activity of BMP-7 in fresh frozen cancellous allograft bone has not previously been demonstrated. This study shows that the freezing and storage of femoral heads allows some maintenance of biological activity. Furthermore we have shown that BMP-7 may be released in proportion to the strain applied to the bone. This confirms that the process of impaction of bone morsels during revision hip arthroplasty may release BMPs that could aid in the incorporation and remodelling of the allograft.


JC Pound DW Green HI Roach ROC Oreffo

Cartilage and bone degeneration are major healthcare problems affecting millions of individuals worldwide. Elucidation of the processes modulating the cell-matrix interactions involved in cartilage or bone formation offer tremendous potential in the development of clinically relevant strategies for cartilage and bone regeneration. We have therefore adopted an ex vivo tissue engineering approach to investigate chondrogenesis and osteogenesis using a mix human mesenchymal progenitor populations encapsulated in biomineralised polysac-charide templates with or without the addition of type-I collagen.

Alginate/chitosan polysaccharide capsules containing 2.5mg/ml type-I collagen and TGF-beta-3 were encapsulated with human bone marrow cells (HBMC), articular chondrocytes or a co-culture at a ratio of 2:1 respectively and placed in a rotating (Synthecon) biore-actor or held in static 2D culture conditions for 28 days, to determine whether the presence of type-I collagen within the alginate could promote the synthesis of an extracellular matrix.

Constructs were stained with alcian blue, sirius red and von Kossa. In bioreactor samples encapsulated with HBMC and type-I collagen, viable cells were present within lacunae, surrounded by a matrix of proteo-glycans and fibrous collagen, which was mineralized. Immunohistochemistry and polarised light microscopy indicated an organised collagenous matrix with extensive expression of type I collagen and bone sialoprotein with small regions of type II collagen. Type X collagen was also expressed indicating the presence of hypertrophic chondrocytes. Within the static HBMC groups, smaller areas of matrix were generated with decreased expression of type-I and type-II collagen. Co-culture bioreactor samples also demonstrated regions of new mineralised bone matrix; however these were less prominent than in the HBMC only groups. No matrix formation was observed in chondrocyte cultures although the cells remained viable as assessed by live/dead staining. Biochemical analysis indicated significantly increased (p< 0.05) DNA in all bioreactor samples in comparison with static constructs and significantly increased protein in HBMC bioreactor constructs in comparison with other cell types.

These studies outline a unique tissue engineering approach, utilizing individual and mixed human mesen-chymal progenitor populations coupled with innovative polysaccharide templates containing type I collagen and bioreactor systems to promote chondrogenic and osteo-genic differentiation.


BJ Bolland K Partridge AMR New DG Dunlop ROC Oreffo

The use of fresh morsellised allograft in impaction bone grafting for revision hip surgery remains the gold standard. Bone marrow contains osteogenic progenitor cells that arise from multipotent mesenchymal stem cells and we propose that in combination with allograft will produce a living composite with biological and mechanical potential. This study aimed to determine if human bone marrow stromal cells (HBMSC) seeded onto highly washed morsellised allograft could survive the impaction process, differentiate and proliferate along the osteogenic lineage and confer biomechanical advantage in comparison to impacted allograft alone. Future work into the development of a bioreactor is planned for the potential safe translation of such a technique into clinical practice.

Methods: HBMSC were isolated and culture expanded in vitro under osteogenic conditions. Cells were seeded onto prepared morsellised allograft and impacted with a force equivalent to a standard femoral impaction (474J/m2). Samples were incubated for either two or four week periods under osteogenic conditions and analysed for cell viability, histology, immunocytochemistry, and biochemical analysis of cell number and osteogenic enzyme activity. Mechanical shear testing, using a Cam shear tester was performed, under three physiological compressive stresses (50N, 150N, 250N) from which the shear strength, internal friction angle and particle interlocking values were derived.

Results: HBMSC survival post impaction, as evidenced by cell tracker green staining, was seen throughout the samples. There was a significant increase in DNA content (P< 0.05) and specific alkaline phosphatase activity (P< 0.05) compared to impacted seeded allograft samples. Immunocytochemistry staining for type I collagen confirmed cell differentiation along the osteogenic lineage. There was no statistical difference in the shear strength, internal friction angle and particulate cohesion between the two groups at 2 and 4 weeks.

Conclusion: HBMSC seeded onto allograft resulted in the formation of a living composite capable of withstanding the forces equivalent to a standard femoral impaction and, under osteogenic conditions, differentiate and proliferate along the osteogenic lineage. In addition, there was no reduction in aggregate shear strength and longer term studies are warranted to examine the biomechanical advantage of a living composite. The therapeutic implications of such composites auger well for orthopaedic applications.


W Khan A Adesida JG Andrew TE Hardingham

Introduction: Autologous chondrocytes harvested from articular cartilage are being used for the repair of focal cartilage defects. The procedure involves injury to the cartilage and alternative sources of stem cells for use in repair are being explored. Stem cells have been found in many tissue including bone marrow and the infrapa-tellar fat pad. Infrapatellar fat pad derived stem cells present a viable and easily accessible source of stem cells for the repair of cartilage defects and tissue engineering applications.

Hypoxia has been shown to improve chondrogenesis in stem cells derived from the bone marrow. We explore the hypothesis that this effect would also apply to stem cells derived from the infrapatellar fat pad.

Materials and methods: Cell aggregates from early passage stem cells isolated from the infrapatellar fat pad were placed in chondrogenic media for 14 days either in a normoxic (20% oxygen) or hypoxic (5% oxygen) environment. Gene expression analysis, DNA and glycosoaminoglycan assays and immunohistochemi-cal studies were performed on the aggregates to assess chondrogenesis.

Results: Cells grown under hypoxic conditions showed significantly improved chondrogenesis as determined by relatively higher gene expression of proteoglycans, collagens and SOX genes. The cell aggregates also had a higher glycosoaminoglycan content and glycosoamino-glycan content per DNA. Immunohistochemical studies confirm enhanced production of collagen types I and II and aggrecan.

Discussion: These findings confirm the previously documented effects of hypoxic culture conditions on stem cells and extend the findings to include infrapatellar fat pad derived stem cells. Our findings suggest that oxygen tension has a role in regulating the function of stem cells as they undergo chondrogenesis. In culture these cells appear to function optimally in an atmosphere of reduced oxygen that more closely approximates documented in vivo oxygen tension. This has important implications in future tissue engineering applications of these cells.


M Mathew R Sen R Nada

Background and objectives: The antiepileptic drug Phe-nytoin (Diphenyl hydantoin) has been documented to have a beneficial effect on wound healing. Its effect on fracture healing has been investigated to a much lesser extend. In this study we have combined histology, his-tomorphometry and radiology in analyzing the effect of phenytoin on fracture healing, following its local administration.

Methods: Twenty-four Wistar strain rats of 8-9 months age were assigned into two groups of 12 each, which had been matched for age, sex and weight. In one group, selected as the study group phenytoin 20 mg/kg was administered through a 24 gauge needle directly on to the fracture site every 72 hours, while in the controls an equivalent volume of normal saline was administered at the same interval. At 28 days radiographic and histo-logical analysis was done.

Results: Radiographic and histological scoring across the control and test animals did not show any statistical difference. Histomorphometric analysis of the callus however showed that the total periosteal callus on either side of the central bridging callus was mineralized to a greater extend in the phenytoin group animals as compared to the control group animals (p= 0.011).

Conclusion: After analyzing our data, we concluded that phenytoin does have an influence in fracture healing, albeit small, which is primarily on the hard callus region. The hard callus region is the high oxygen tension region and the first region to differentiate. It appears that the effect of phenytoin is probably exerted at the early mesenchymal differentiation stage. However our preliminary work shows that the effect is small and it is not justifiable at this stage to advocate the use of phe-nytoin clinically to augment fracture healing.


A Yousef R Hill D Wilson DA Walsh

Aim: Severity of knee osteoarthritis (OA) can be defined clinically, radiologically, or pathologically. The Système Française D’Arthroscopie (SFA) is a validated method of grading and scoring the severity of changes on the articular surface as observed through the arthroscope. We have validated a modification of the SFA system for use with digital photographs of pathological samples.

Material and Method: After Ethics Committee approval, both tibial plateaux and femoral condyles were collected from 84 patients undergoing total knee replacement or at post mortem. Extent and grading of cartilage changes were documented for the 4 compartments of each sample on a diagram using direct visualisation and probing (Pathological Scores). In addition, each sample was digitally photographed at standard magnification and illumination, archived, graded and scored (Photographic Scores). A second observer (AY) also graded and scored photographic images for 72 compartments of the first 18 cases.

Data analysis: Repeatability was measured as Repeatability Coefficients (Bland and Altman, Lancet1986; 1; 307–10). 95% of the differences between 2 measurements of a case are expected to fall within the Repeatability Coefficient. Associations between compartments are expressed as Pearson correlation coefficients.

Results: For each of the 4 compartments studied, scores ranged from -2.2 to +717.8, representing the full range of possible scores. Allocation of scores to diagrams was highly repeatable (Repeatability Coefficient = 50). There was good agreement between Pathological and Photographic Scores (Repeatability Coefficient = 88). There was moderate agreement between Photographic Scores allocated by the 2 observers, with greatest agreement for low (< 200) and high (> 500) scores. Scores for each compartment correlated with scores for each of the other 3 compartments (R values 0.7 to 0.9, all P < 0.005).

Conclusion: Our modified SFA system permits scoring of OA severity using digital photographs of pathological samples. Our data support the view that OA affects the entire joint, and that a single compartment (e.g. medial tibial plateau) can be taken as broadly representative of the tibiofemoral joint as a whole.


BE Gerber M Biedermann

Massive disc herniations after surgical decompression develop secondary back pain due to important loss of nucleus material with instability. No earlier proposed method to restore disc function was biological.

Chondrocyte culturing allows living repair of lost disc tissue. The contained disc space appears particularly suitable for receiving those tissue cultures. Surprisingly disc replantations had not been attempted before.

In 1996 two women and one man (aged 38-55) underwent open resection of a massive disc herniation by hemi-laminotomy, twice at L5-S1, once at L4/5.

All the excised disc tissue was given to tissue culture in an identical protocol as in autologous chondrocyte transplantation (ACT) for articular cartilage repair. After sufficient cell multiplication (11.5-23 millions living cells in 750 μl) four weeks later the engineered autolo-gous disc tissue was injected in suspension through a contra-lateral puncture under local anaesthesia.

In prospective follow up a simplified Oswestry Disability Index was recorded and functional radiographs and NMR were taken after one, three, six and nine years.

All three patients remained freed from radicular pain and vertebral symptoms over the whole follow up period. Two patients never had functional restrictions nor loss of working capacity (Oswestry 1 and 6), one after retirement at 5 years developed rheumatoid disease but is still unchanged at the lumbar spine. The third patient partially recovered from preoperative radiculop-athy (slight loss of strength and sensitivity S1) but still works, with minor adaptations to his original professional activity (Oswestry 18).

Functional radiographs up to the last follow up didn’t show vertebral instability. In all cases the replanted intervertebral disc space remained unchanged with minimal widening in one case.

In NMR all three discs had partial signal recovery. Twice during the first year a new outgrowth of disc tissue was observed at the site of the primary disc herniation opposite to the replanting injection, without any clinical correlation.

Three cases with massive lumbar disc herniations showed good clinical and large anatomical recovery persisting nine years after reimplantation of engineered autologous disc tissue. The encouraging results of this small pilot study led to further closely monitored clinical applications before wider propagation of biological disc repair surgery.


JA Gallagher C Lee M Schablowski P Aldinger H Gill DW Murray

Background: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range and diminished femoral rollback. It is postulated that this may be due to a flat tibial tray replacing the domed anatomy of the lateral tibia, tightening the posterolateral flex-ion gap. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to increase; (i) the posterolateral flexion gap in deep knee flexion (ii) meniscal bearing movement and (iii) lateral femoral condyle (LFC) rollback. A cadaveric study was designed to test these three outcomes.

Methods: The sagittal plane kinematics of seven thawed fresh frozen cadaver specimens within an upright Oxford testing rig were assessed under three different conditions; (i) intact normal cadaver knee (ii) flat lateral Oxford UKR (iii) domed lateral Oxford UKR. Each condition was tested during three ranges of motion (ROM) and data recorded during a flexion or extension half cycle. Knee flexion angle (KFA) and displacement measures of the lateral collateral ligament (LCL), LFC rollback and anteroposterior meniscal bearing movement were performed throughout knee ROM using four [3 linear, 1 rotary] potentiometer devices. Potentiometer data was recorded as a voltage reading and subsequently converted to either a millimetre displacement or degree measure using a calibration formula. All data points were compared at 10 degree interpolations of KFA.

Results: The flexion half cycles demonstrated the flat Oxford lateral UKR achieved 80.7% of normal cadaveric LFC rollback. The domed Oxford lateral UKR achieved 108.8% of normal cadaveric LFC rollback. The ratio of LFC rollback in the domed to flat UKR’s was 1.35 times (134.9%). Meniscal bearing movement in flexion demonstrated a domed to flat UKR ratio of 1.3 times (129.7%). Similar values were obtained for extension half cycles in favour of the domed Oxford lateral UKR. No significant differences were identified in LCL measures.

Conclusions: The domed Oxford lateral UKR implant allows for improved bearing movement and femoral rollback when compared to the flat Oxford lateral UKR. The sagittal plane kinematics of the domed Oxford lateral UKR as represented by femoral rollback values approximate those of the normal cadaver knee.


M Magra S Hughes A ElHaj N Maffulli

Background and objectives: Tenocytes change their structure, composition and mechanical properties to adapt to mechanical loading. Voltage gated and mecha-nosensitive ion channels may play a key role in human tenocytes to regulate some or all initial responses to mechanical stimulation. To date, there has been no direct investigation of ion channel expression by human tenocytes.

Methods: Human tenocytes were cultured from patellar tendon samples harvested from five patients undergoing routine total knee replacement surgery (mean age: 66 years; range 63-73 years). RT-PCR, Western Blotting and whole cell electrophysiological studies were performed to investigate the expression of different classes of ion channels within tenocytes.

Results: Human tenocytes express mRNA and protein encoding voltage operated calcium channel (VOCCs) sub-units (Ca alpha 1A, Ca alpha 1C, Ca alpha 1D, Ca alpha2 delta1) and the mechanosensitive tandem pore domain potassium channel (2PK+) TREK-1. They exhibit whole cell currents consistent with the functional expression of these channels. In addition, other ionic currents were detected within these tenocytes consistent with the expression of voltage gated potassium channels, voltage gated sodium channels, and other outwardly rectifying leak currents.

Discussion and conclusions: Human tendon cells show increased levels of intracellular calcium when stress is applied to them. One of the mechanisms by which this occurs is by the influx of extracellular calcium into the cell via ion channels. VOCCs and TREK channels have been implicated in mechanotransduction signalling pathways in numerous connective tissue cell types. This study suggests that these mechanisms may be present in human tenocytes. In addition, human tenocytes may express other channel currents. Ion channels may represent potential targets for the pharmacological management of chronic tendinopathies.


F Alvi L Yang T N Board

Fine-wire fixators are a powerful tool in the management of acute fractures, non-unions, mal-unions and limb lengthening. The tension in the wires is very important in achieving stiffness of the whole fixator construct and current guidelines suggests tensioning wires to 900-1275N. There is evidence that during long term use the tension in the wires can reduce significantly. The effects of a reduction in tension on the fixator stiffness has been well characterised however the effect on the stresses imparted on the bone at the interface with the wire remain unknown. The main aim of this study was to identify any relationship between wire tension and wire-bone interface pressure.

An experimental system utilizing artificial cancellous bone mounted on a tensioned 2mm wire and then loaded by a material testing machine was employed. Pressure sensitive film allowed determination of interface stresses. The experiment was repeated at wire tensions of 600, 900 and 1200N. All other variables were kept the same during testing.

The highest pressures were found closest to the wire. At 1200N the peak pressures were 6-8 MPa, at 900N of tension the pressures rose to 8-10 MPa and at 600N pressures up to 14 MPa were observed. Deeper in the bone the pressures observed at 600N tension were double that seen at 1200N.

This is the first characterisation of the relationship between interface pressure and wire tension in fine-wire fixators. At 1200N the highest pressures are less than the compressive yield strength of cancellous bone whereas at both 600 and 900N pressures are greater than the yield which may lead to loosening. We therefore conclude that a tension of 1200N be employed when applying fine-wire fixators and during long term treatments the tensions should be regularly monitored to prevent loss of tension.


DW Green J Pound K Partridge R Tare D Walsh S Mann R Oreffo

The ability to generate replacement human tissues on demand is a major clinical need. Indeed the paucity of techniques in reconstructive surgery and trauma emphasize the urgent requirement for alternative strategies for the formation of new tissues and organs. The idea of biomimesis is to abstract good design principles and optimizations from nature and incorporate them in the construction of synthetic materials and structures. Direct appropriation of natural inorganic skeletons is also biomimetic since their unique properties inform us on ways to generate functional, optimized scaffolds.

A number of well characterized natural skeletons were investigated as potential scaffolds for tissue regeneration using mesenchymal stem cell populations. Marine sponges, sea urchin skeletons and nacre were found to possess unique functional properties that supported human cell attachment, growth and proliferation and provided organic/ inorganic extracellular matrix analogues for guided tissue regeneration.

A good understanding of the processses involved in biomineralisation and the emergence of complex inorganic forms has inspired synthetic strategies for the formation of biological analogues (organised inorganic materials with biological form). We have developed two functional examples of biological structures generated using biomimetic materials chemistry with applications for human tissue regeneration. Mineralised biopoly-saccharide microcapsules provided enclosed micro-environments with an appropriate physical structure and physiological milieu, for the support of the initial stages of tissue regeneration combined with a capacity to deliver human cells, plasmid DNA and controlled release of biological factors such as cytokines. Calcium carbonate porous microspheres analogous to microscopic coccolithophore shells provided a template for tissue formation and a mechanism for the delivery of DNA and functional biological factors. These biomi-metic structures have considerable potential as scaffolds for skeletal repair and regeneration, particularly when combined with inductive and stimulatory biological factors (cytokines, morphogens, signal molecules) and plasmid DNA carrying with them chemical cues that modulate and direct permanent tissue formation complimentary with the host.


HA Gray AB Zavatsky L Cristofolini HS Gill

Finite element (FE) analysis is widely used to calculate stresses and strains within human bone in order to improve implant designs. Although validated FE models of the human femur have been created (Lengsfeld et al., 1998), no equivalent yet exists for the tibia. The aim of this study was to create such an FE model, both with and without the tibial component of a knee replacement, and to validate it against experimental results.

A set of reference axes was marked on a cleaned, fresh frozen cadaveric human tibia. Seventeen triaxial stacked strain rosettes were attached along the bone, which was then subjected to nine axial loading conditions, two four-point bending loading conditions, and a torsional loading condition using a materials testing machine (MTS 858). Deflections and strain readings were recorded. Axial loading was repeated after implantation of a knee replacement (medial tibial component, Biomet Oxford Unicompartmental Phase 3). The intact tibia was CT scanned (GE HiSpeed CT/i) and the images used to create a 3D FE mesh. The CT data was also used to map 600 transversely isotropic material properties (Rho, 1996) to individual elements. All experiments were simulated on the FE model. Measured principal strains and displacements were compared to their corresponding FE values using regression analysis.

Experimental results were repeatable (mean coeffi-cients of variation for intact and implanted tibia, 5.3% and 3.9%). They correlated well with those of the FE analysis (R squared = 0.98, 0.97, 0.97, and 0.99 for axial (intact), axial (implanted), bending, torsional loading). For each of the load cases the intersects of the regression lines were small in comparison to the maximum measured strains (< 1.5%). While the model was more rigid than the bone under torsional loading (slope =0.92), the opposite was true for axial (slope = 1.14 (intact) 1.24 (implanted)) and bending (slope = 1.06) loads. This is probably due to a discrepancy in the material properties of the model.


A Aziz HI Roach

Osteoarthritis (OA) is characterised by the progressive loss of the articular cartilage. This is accompanied by change in phenotype from cells expressing chondrocytic genes to cells, termed ‘degradative’ chondrocytes, that express aggrecanases and collagenases. To understand the cellular events involved, human articular cartilage was obtained from femoral heads after arthroplasty due to OA, fracture of the neck of femur (#NOF) due to osteoporosis, or from a 14 year old male (CDH). Samples were graded according to the new OARSI system (Osteoarthritis and Cartilage, 2006, 14:13–29) and par-affin sections were immunostained for c-Myc (marker of cellular activation), S100 (typically expressed in chon-drocytes), Sox-9 (expressed in early-stage chondrocytes) and nucleostemin (a stem-cell marker). In addition, some specimen were incubated with fluorescent probes to identify metabolically activated cells (CellTracker green).

All chondrocytes, irrespective of OA grade, were immunopositive for S100, but there were differences in the other parameters. Cartilage from the 14-year old (OARSI grade =0) was characterized by no loss of proteoglycans (safranin-O) in the superficial zone and absence of c-Myc, Sox-9 and nucleostemin in all articular chondrocytes. In #NOF cartilage, proteoglycan loss was evident in the very superficial zone. Many chondro-cytes in that zone showed bright green fluorescence with CellTracker-green and were c-Myc positive, consistent with cellular activation. Sox-9 and nucleostemin were absent. Mid-zone and deep zone chondrocytes showed no change. In low-grade OA samples (OARSI = 1-2), the zone of proteoglycan loss had increased, the Cell-Tracker-green/c-Myc positive chondrocytes in that zone had divided to form clusters of 4-8 cells. Occasional cells were positive for nucleostemin. Mid-zone and deep zone chondrocytes still showed no change. In high-grade fib-rillated OA cartilage (OARSI = 3-4) the superficial and mid zones had been eroded, leaving the deep zone at the surface. Chondrocytes were typically found in large clones, which were all immunopositive for c-Myc as well as for nucleostemin and Sox-9.

The results show that cellular activation starts near the surface and progresses to the deep zone. The presence of nucleostemin and Sox-9 suggests that de-differentiation may be involved in the phenotypic change from the chondrocytic to the degradative phenotype.


A Unnithan R Wells G Blunn A Goodship

Background: As the understanding of bone repair mechanics has advanced the integrity of the bone pin interface has emerged as a key factor in determining the success of external fracture fixation. The benefits of using pins coated with Hydroxyapatite (HA) are well documented however the thickness of the conventional plasma spray coating precludes its use for modification of the surface of fine features in implants. Consequently new electro-chemical techniques for pre-coating implants with a ‘biomimetic’ HA layer using simulated body fluids (SBF) have been pioneered. In this study we test the hypothesis that varying the technique for deposition of HA by electrolysis of SBF alters the morphology of the HA surface which will modify the level of osseointegration. Method: Three alternative methods of HA coating the Barerre, Redepenning and Kumar techniques were compared. Tantalum coated stainless steel pins were coated then used to stabilise a mid-diaphyseal osteotomy in three sheep using an orthofix fixator for a period of ten weeks. Insertion and extraction torques were measured to calculate the pin performance index (PPI). Sections of the bones were then examined using scanning electron microscopy to determine the percentage of bone in contact with the pin surface and the percentage of new bone formation. Results: The different coating protocols resulted in different HA crystal morphologies. The extraction torque exceeded the insertion torque for both the Barerre and Redepenning methods and their PPI exceeds that of plasma spray coatings. The Redepenning technique was shown to perform sig-nificantly better than both the Barerre (p=0,001) and Kumar (p=0,001) techniques with 49.4% of the pin surface in contact with bone. These results were mirrored on analysis of new bone formation with the Redepen-ning technique showing 70.2% of new bone formation compared to the Barerre (55.4%) and Kumar (53.8%) methods. Conclusion: These results indicate that the Redepenning technique is the most effective for creating a bio mimetic HA coating in terms of bonding to bone and promoting new bone formation. This technique holds significant advantages over the conventional plasma spray technique for example the coating thickness can be easily controlled and additional proteins such as bone morphogenic proteins and antibiotics can be incorporated. It may therefore represent a new era in the use of HA coating.


XC Wei C Xiang

Studies have demonstrated that use of peptides including bone morphogenetic proteins, fibroblast growth factors, insulin-like growth factor (IGF), and transforming growth factor-beta (TGF-beta), may be pivotal in promoting chondrogenesis and matrix development. As a prelude to studies, it is necessary to determine which gene or combination of genes gives the best result to improve proliferation of chondrocytes and synthesis of extracellar matrix. We investigate the effect of transfec-tion of recombined rat TGF-beta1 and recombined rat IGF-1 on rabbit chondrocytes ex vivo.

Chondrocytes were isolated from articular cartilage of knee joint of mature New Zealand White rabbits. Cells were seeded at a density of 1×105 cells/ml into 6-well plates. Monolayer cultures were infected respectively with recombinant rat gene pcDNA3+TGF-beta 1, pAT153+IGF-1 and lac Z reporter gene by using lipo-fectamine, and were co-transfected by pcDNA3+TGF-beta 1, pAT153+IGF-1. The control group remained uninfected. To determine whether the genes transcript were translated and the gene products were released, the synthesis of TGF-beta 1, IGF-1,and type II collagen were measured by in situ hybridization, immunohisto-chemistry and immunofluoroscopy. The proliferation of chondrocytes was detected by flow cytometer and 3H-TdR radiolabeling.

The expression of TGF-beta1,IGF-1 and type II collagen in recombinant rat gene transfection groups was high beyond control levels and the lac Z gene levels (P< 0.05). The co-transfection elevated these factors synthesis beyond the levels of single gene transfection (P< 0.05). In pcDNA3 +TGF-beta1 transfection group, the level of TGF-beta1 and type II collagen were higher than the levels of pAT153+IGF-1 group (P< 0.05), while the content of IGF-1 has no significant difference with pAT153+IGF-1 group. By using flow cytometer, the chondrocytes ratio of S stage in pcDNA3+TGF-beta 1 group, pAT153+IGF-1 group and co-transfection group was 33.4%,28.7% and 40.1% respectively, which was higher than 5.6% and 4.8% of the control group and the lac Z gene group (P< 0.05). The 3H-TdR radiolabeling detection also indicated that the recombinant rat gene transfection groups improved the chondrocytes proliferation, and co-transfection group has the best effect.

The data presented support that transfection of genes of TGF-beta1 and IGF-1 into chondrocytes ex vivo can greatly increase cell proliferation and matrix synthesis, and the co-transfection can provoke more increase in the synthesis of TGF-beta1, IGF-1 and type II collagen, which encourages the further research of gene potential therapeutic use for osteoarthritis.


BJ Bolland S Tilley K Partridge JM Latham ROC Oreffo DG Dunlop

Introduction: Bone is unique with a vast potential for regeneration from cells with stem cell characteristics. With an increasing aging population, clinical imperatives to augment and facilitate tissue repair have highlighted the therapeutic potential of harnessing mes-enchymal populations from bone. We describe laboratory and clinical findings from two clinical cases, where different proximal femoral conditions (AVN, bone cyst) were treated with impacted allograft augmented with marrow-derived allogeneic progenitor cells.

Methods: Marrow was aspirated from the posterior superior iliac crest and seeded onto prepared washed morsellised allograft. The seeded graft was left for 40 minutes to allow adherence of the marrow-derived osteoprogenitor cells prior to impaction into the defect. Samples of the impacted graft were taken for in-vitro analysis of cell viability, histology and biochemical analysis of cell number and osteogenic enzyme activity. The total force imparted during impaction was calculated using a load cell, with three independent surgeons performing a laboratory simulation of the impaction technique.

Results: Both patients made a rapid clinical recovery after an overnight stay. Imaging confirmed filling of the defects with increased density on plain radiographs suggesting good impaction of the graft composite. Immu-nohistochemical staining of graft samples demonstrated that a living composite graft with osteogenic activity had been introduced into the defects as evidenced by cell tracker green viability and alkaline phosphatase (osteogenic marker) expression and specific activity. The average peak forces during impaction were 0.7kN corresponding to average peak stresses within the graft of 8.3MPa. Similar forces were seen between operators.

Discussion: Replacement of bone loss remains a major challenge in orthopaedic practice. Although allograft remains the gold standard where large volumes preclude autograft, allograft has little osteoinductive potential. We demonstrate that marrow-derived cells can adhere to highly washed morsellised allograft, survive the impaction process, and are of the osteoblastic phenotype creating a living composite. Thus we conclude, impacted allograft seeded with autologous marrow cells allows the delivery of a biologically active scaffold for the treatment of bone deficiency. In addition this is a novel straightforward technique, surgeon independent and with applications in a number of orthopaedic scenarios.


RM McCann G Colleary C Geddis SA Clarke D Marsh GR Dickson

Background & Objectives: Osteoporosis is one of the most prevalent bone diseases worldwide with fractures its major clinical consequence. Studies on the effect of osteoporosis on fracture repair are contradictory and although it might be expected for fracture repair to be delayed in osteoporotic individuals, a definitive answer still eludes us. Subsequently, the aim of this study was to attempt to clarify any such effect.

Methods: Osteoporosis was induced in 53 female Sprague-Dawley rats by ovariectomy (OVX) at 3 months. A femoral fracture was produced in these animals 12 weeks later {OVX+Fracture group (OVX+F)}. A control group received the fracture only group (F) at 6 months. The fracture consisted of an open osteotomy held with a unilateral external fixator. Outcome measures include histology, motion detector analysis, pQCT, biomechanical strength testing (BST) and digital radiography. Digital radiographs were taken at time of OVX, fracture (confirming satisfactory reduction) and sacrifice from which relative bone density (BMD) measurements were calculated.

Results: OVX+F animals were significantly heavier than F animals at fracture and sacrifice (p< 0.001 for both) and moved significantly less in days 1-4 (p=0.032) and 5-9 (p=0.020) post-fracture. Relative BMD measured in distal femur at fracture and sacrifice was significantly greater in F group (p< 0.001 for both). Furthermore, there was a significant decrease in relative BMD from fracture to sacrifice in OVX+F group (p< 0.001). pQCT showed a significantly greater total BMD {contralateral (p=0.021) and fractured femora (p< 0.001)} and trabecular BMD (p< 0.001 both limbs) in the distal femur of the F group. Histologically, no statistical differences were found, however, the F group generally displayed the most advanced repair. In the contralateral limb, the F group had significantly greater load to failure at 6 (p=0.026) and 8 (p=0.042) weeks and was significantly stiffer at 8 weeks (p=0.050). In the fractured leg, stiffness was significantly greater in the F group at 8 weeks (p=0.001).

Conclusion: OVX was linked to increased body weight, decreased motion, decreased BMD (with particular loss in trabecular BMD), and reduced mechanical properties. OVX did not have a significant effect on fracture healing and although there was no reduction in BMD at the fracture site, histology and reduced stiffness suggest it was delayed.


Z Yang G Li X Wei

Once damaged, articular cartilage has limited capacity for self-repair due to their avascular and acellular nature. Tissue engineering approaches using cultured chondrocytes and biomaterials as scaffoldings hold promises for repairing cartilage defects. However, the source of articular chondrocytes is limited and the chon-drocytes may de-differentiate when cultured for a prolonged period. Bone marrow derived mesenchymal stem cells (BMSCs) have multi-differentiation potentials and autologous BMSCs are easy to obtain and culture with no/little immunological reaction when re-implanted.

24 NZW rabbits were used. Rabbit autologous BMSCs were obtained through marrow aspirations and expanded in culture under the chondrogenic induction media (DMEM, 10% FCS, plus 10ng/ml TGF-β1) for 3 weeks. A full-thickness articular cartilage defect (3 mm in diameter and 3 mm in depth) was created on both medial condyles in the rabbit. For experimental group (16 joints), the defects were filled immediately with alginate capsules containing autologous chondrogenic cells (8.5 x 104); for the control groups, the defects were filled with either alginate capsules alone (16 joints) or left untreated (16 joints). All the animals were terminated at 6 and 12 weeks after surgery and the cartilage samples were harvested for histology, immunochemistry and in situ hybridization examinations.

For histology, in the experimental group the defects were filled with immature hyaline-like cartilaginous tissues at 6 weeks; by 12 weeks the newly formed cartilage showing signs of remodeling and integrating into the surrounding articular cartilage. The expression of type II collagen in the newly formed cartilaginous tissues was confirmed by immunohistochemistry and by in situ hybridization methods. In the control groups, the defects were mainly filled with fibrous tissues in all the animals at the two time points examined. We have used Wakitani cartilage grading system for semi-quantitative histological evaluation. Significant lower scores (with superior histology) were found in the experimental group comparing to the two control groups.

Our results confirmed that full-thickness articular cartilage defects can be repaired by chondrogenically differentiated autologous BMSCs seeded into alginate capsules. Further studies are ongoing to explore the long term outcome of this treatment approach as well as using new scaffolds for cartilage tissue engineering.


EA Lingard SY Mitchell RM Francis RT Peaston FN Birrell D Rawlings AW McCaskie

This study aimed to determine the prevalence of osteoporosis in patients awaiting hip and knee replacement for osteoarthritis and to review them two years later to determine the changes in bone density following joint replacement.

Patients aged between 65 and 80 years awaiting total hip or knee replacement were invited to participate. Lumbar spine, bilateral femoral and forearm bone mineral density (BMD) measurements were obtained using dual energy x-ray absorptiometry. BMD values were standardised using previously published T-scores and Z-scores. To assess clinical status, patients completed a questionnaire including the Western Ontario and McMaster University OA Index (WOMAC). All measurements were repeated at two-years.

Participants included 199 patients (84 hips and 115 knees) with a mean age of 72 years (SD 4.0) and were predominantly female (hips 67%, knees 50%). At baseline 46/199 (23%) patients (39 females) had evidence of osteoporosis (WHO definition) at one or more sites with the highest prevalence at the forearm (14%). At two-years 144 patients attended for review with 128 having undergone hip (56) or knee (72) replacement. At this review 39/144 (27%) patients (33 females) had evidence of osteoporosis at one or more sites with the highest prevalence at the forearm (22%). The greatest bone loss occurred at the forearm with median BMD change of minus 4% for females (25th percentile minus 7.3%, 75th percentile minus 1.9%) and minus 2.9% for males (25th percentile minus 4.6%, 75th percentile minus 1.1%). There was a significant difference in WOMAC Pain scores at follow-up between the osteo-porotic and non-osteoporotic knee patients (67 versus 81, p=0.002) indicating that osteoporotic patients had greater knee pain.

We have identified the forearm as not only the site with the highest prevalence of osteoporosis but also the greatest bone loss at follow-up. Further evaluation of forearm bone density measurements in the preopera-tive assessment and follow-up of patients awaiting joint replacement for hip and knee OA is required. Larger studies are needed to confirm our finding that the presence of osteoporosis is predictive of worse patient-reported outcomes of knee replacement.


NP Zant P Heaton-Adegbile J Tong

A new hip simulator has been developed at the University of Portsmouth and manufactured at Simulation Solutions, Ltd. (UK) for the purpose of fatigue testing of implanted acetabula. Although hip simulators for in vitro wear testing of prosthetic materials in total hip arthroplasty (THA) have been available for many years, similar equipment has yet to appear for endurance testing of fixations in cemented THA, despite of considerable evidence of late aseptic loosening as one of the most singnificant failure mechanisms in acetabular replacements [1].

In this study, a new four-station hip simulator designed for in vitro fatigue testing of implanted acetabula is described. The four-station machine has spacious test cells that can accommodate full hemi-pelvic bones with implants. The machine was designed to simulate the direction and the magnitude of the hip contact force relative to the acetabular cup coordinate system, as reported by Bergmann et al. [2], under typical physiological loading conditions, including stair climbing as well as walking. The controls were designed as such that each station may operate independently with a loading waveform that is fully programmable. The motions were achieved through two encoded servomotors suitably connected to gearboxes; while the loading was realised through a close-looped pneumatic system. The motions and the resultant hip contact force of the new hip simulator were evaluated, and found to be satisfactory in reproducing the typical physiological loading waveforms including normal walking, ascending and descending stairs.

Experiments have been carried out using third generation composite bones (Pacific Research Laboratories, Inc.) and bovine bones. Both hip simulator and conventional fatigue testing were carried out. The implanted acetabula were CT scanned periodically to monitor the damage development in the fixation. Preliminary results seem to suggest that both magnitude and direction of the hip contact force influence the integrity of the fixa-tion, and failures appear to occur earlier in samples tested using the hip simulator. The predominant failure mechanism appears to be interfacial fracture, consistent with clinical observation of radiolucent lines and bone-cement interfacial failure.


RM McCann G Colleary C Geddis SA Clarke D Marsh GR Dickson

Background & Objectives: Statins have been shown to stimulate bone formation in vivo and in vitro in rodent models1 generating interest in the possibility that they may be useful therapeutic agents for osteoporosis. The major clinical consequence of osteoporosis are fractures that occur and although there is no firm evidence, there is a perceived associated delay in fracture repair. We examined the influence of atorvastatin on fracture repair in an ovariectomised rat fracture model.

Methods: 126 Sprague-Dawley rats had an ovariectomy (OVX) at three months and a femoral fracture (F) at six months. The fracture consisted of an open osteotomy held with an external fixator. All animals were randomly assigned into groups 1. OVX+F and early atorvastatin; 2. OVX+F and late atorvastatin; 3. OVX+F. Atorvas-tatin (5mg/kg) was given daily by oral gavage for three months in-group 1 between OVX and fracture and from time of fracture to sacrifice in-group 2. Outcome measures were histology, peripheral quantitative computed tomography (pQCT), biomechanical strength testing (BST) and digital radiography. Digital radiographs were taken at time of OVX, fracture (confirming satisfactory reduction) and sacrifice from which relative bone density (BMD) measurements were calculated.

Results: Non-statin treated animals moved significantly more in 4 days post-fracture (p=0.015), had signifi-cantly more relative (p=0.037) and total BMD (distal femur) than statin treated (p=0.040, early and p=0.036, late treatment). Total BMD at the fracture site was also significantly greater in the OVX+F than the late statin group (p=0.047) while in the adjacent site of the con-tralateral limb, the early statin group had significantly more (p=0.018) than the late statin group. However no differences were found between the early statin and OVX+F groups. Histologically, the rate of repair increased significantly in early statin (p=0.013) and OVX+F (p=0.011) groups. BST data showed no signifi-cant difference in stiffness at six or eight weeks.

Conclusion: Fractures healed in all three groups. Statins did not prevent OVX induced bone loss. Initial evidence suggests that early statin treatment may have a positive effect on early fracture, as shown by x-ray analysis and histology, however this effect was lost by week 8. Overall the evidence suggests that atorvastatin may have impaired fracture repair, particularly with late administration (relative BMD and pQCT results).


RK Trehan PA Mitchell SH Bridle

Purpose: Periprosthetic fractures around hip prostheses are difficult problems because these fractures range from the very simple (requiring no surgical intervention) to the complex (requiring major surgery). This paper evaluates the primary stability and restoration of femoral bone stock following treatment of Vancouver type B-2 periprosthetic fracture of the femur using an extensively hydroxy-apatite coated revision stem implant.

Methods: We have prospectively reviewed 9 cases with B-2 periprosthetic fracture operated at our centre between 1996 to 2001. Of the nine patients, 4 were male and 5 female. The mean age was 76.7 years (50-92). All patients were treated by femoral revision using an extensively hydroxy-apatite coated titanium revision femoral stem (Restoration HA, Stryker, Rutherford, NJ). Fixation was augmented with a combination of cerclage cables and onlay cortical strut allografts.

Results: There has been no loss to follow-up. 1 patient died, but at most recent follow-up the fracture had united with radiological evidence of bone on-growth to the stem. Mean follow up in the rest of the cohort was 3.3 years. There was radiological evidence of fracture union in all patients. Mean subsidence of the stem was 0.22mm. At most recent follow-up the mean Harris Hip Score had improved to 77.2 (63-93). Favourable bone remodelling was observed in all patients with no evidence of stress shielding so far. At most recent follow-up there have been no cases of mechanical failure, deep infection or dislocations. No patient is awaiting further revision.

Conclusion and Significance: Te Restoration HA stem has produced excellent clinical results in our study. We have observed no intra operative fracture and low postoperative complication rate. We are extremely encouraged by the observed femoral remodelling. There has been no case of mechanical failure as yet and there is no reason to expect, once union and on-growth have occurred, that loosening will be a problem. In treating this challenging and increasingly common complication of total hip replacement, femoral revision using an extensively HA coated revision femoral component offers a reliable method of femoral fixation leading to successful fracture healing and early return to function.


PT Vadillo AJ Martin SN Racey AHRW Simpson BS Noble

The use of stem cells in tissue engineering has emerged as a promising therapy for the repair of bone and cartilage defects. Targeted delivery of stem cells requires a substrate to maintain the cells at the repair site, as well as to provide the physical cues, such as mechanical strain, for encouraging differentiation and expression of the mature cell phenotype. The strains that will be generated in cells residing on the scaffold is dependent on the scaffold material, as well as both the fibre thickness and the fibre orientation in the scaffold. To encourage uniform bone matrix generation throughout the scaffold, it is desirable that the strain be uniformly distributed and that the internal pore architecture be precisely controlled to maximise media diffusion. This requires an optimised scaffold design and a manufacturing technique that allows for precise control over the scaffold’s internal architecture.

Scaffold architecture was optimised by performing a series of finite element analyses (FEA) on computer aided design (CAD) models of Polycaprolactone (PCL) scaffolds. The mechanical properties of PCL were used to yield an accurate strain profile of scaffolds with different fibre orientations. Having determined the optimal scaffold geometry, PCL scaffolds were manufactured using a fibre deposition technique that yielded three-dimensional objects with this geometry. During manufacture, a PCL solution was extruded into a non-miscible solvent which precipitated out PCL fibres in repetitive layers. Of the geometries tested with FEA, a 90 degree rotation of adjacent layers with a 50% offset of parallel strands was found to provide the optimal strain distribution (60% increase in surface exposed to strain). Histomorphometry was used to assess the exact dimensions of the scaffold produced. Fibre spacing was found to be precisely controlled to 380 +/- 10 microns within the layers and the fibre thickness was controlled to 270 +/- 10 microns.

This demonstrates that FEA can be used to predict the strain distribution of different CAD models and that the fibre deposition solvent extrusion technique can be used to accurately manufacture PCL scaffolds that match the desired architecture.


WS Khan R Jones L Nokes DS Johnson

Patella and extensor mechanism injuries are common injuries and are generally managed with some degree of immobilisation and partial weight bearing to facilitate healing. The aim of this project was to determine the type of immobilisation or splintage during partial weight bearing that results in minimal forces acting through the extensor mechanism.

Gait analysis studies were performed on eight healthy male subjects mobilising partially weight bearing. Measurements were taken for six types of immobilisation: locked at 0, 10, 20, 30 degrees and unlocked in an orthotic knee brace, and without a brace. The ground reaction force, knee joint angle and the knee flexion moment were measured using Qualisys Track Manager and Visual 3D Software. The extensor mechanism moment and the extensor mechanism force were calculated using static equilibrium equations and documented data. A one-way analysis of variance statistical test was performed to determine the statistical significance of the differences between the six types of immobilisation.

There was a direct relationship between the knee flex-ion angle and the extensor mechanism force. The extensor mechanism force at 0 degrees of immobilisation was significantly lower than that for 20 and 30 degrees (p< 0.05). The increase in the extensor mechanism moment arm with increasing knee flexion was not suf-ficient to offset the increase in the extensor mechanism force caused by the increase in the knee flexion moment. The results also showed that the knee flexion angle does not always correspond with the angle set at the knee brace; however they did exhibit a direct relationship.

These results have important implications for the management of patients with patella and extensor mechanism injuries. The results suggest that improvements in knee brace design to allow 0 degrees of knee flexion, rather than the 10 degrees as seen in this study, are likely to result in significantly reduced extensor mechanism tensile forces.


S Wimsey CF Lien S Sharma PA Brennan HI Roach GD Harper DC Gorecki

Introduction: Osteoarthritis has historically been thought of as a degenerative joint disease, but inflam-mation and angiogenesis are increasingly being recognised as contributing to the pathogenesis, symptoms and progression of osteoarthritis. Beta-dystroglycan is a pivotal element of the transmembrane adhesion molecule involved in cell-extracellular matrix adhesion and angiogenesis. Matrix metalloproteinases are the main enzymes responsible for cartilage extracellular matrix breakdown and are also implicated in both angiogen-esis and beta-dystroglycan degradation in a number of malignancies. We aimed to investigate the expression and localisation of beta-dystroglycan and matrix metal-loproteinase 3, 9, and 13 within cartilage, synovium and synovial fluid and establish their roles in the pathogenesis of osteoarthritis.

Methods: Following ethical committee approval, cartilage, synovium and synovial fluid were obtained from the hip joints of 5 osteoarthritic (patients undergoing total hip replacement) and 5 control hip joints (patients undergoing hemiarthroplasty for femoral neck fracture). The samples were analysed for beta-dystroglycan expression using Western Blotting and for the distribution of beta-dystroglycan, matrix metalloproteinase 3, 9, and 13 using immunohistochemistry on paraffin embedded tissue.

Results: Whilst no significant expression of beta-dystro-glycan was found in cartilage or synovial fluid, beta-dys-troglycan was expressed in the smooth muscle of both normal and osteoarthritic synovial blood vessels. Moreover, beta-dystroglycan was expressed in endothelium of blood vessels of osteoarthritic synovium, but not in the normal endothelium. In the endothelium of osteo-arthritic synovial blood vessels, beta-dystroglycan co-localised with matrix metalloproteinase 3 and 9. Discussion: Our results demonstrate that beta-dystro-glycan does not act as a cell adhesion molecule binding chondrocytes to the extracellular matrix. However, specific immunolocalisation of beta-dystroglycan within endothelium of inflamed osteoarthritic blood vessels suggests that beta-dystroglycan may play a role in angiogenesis associated with osteoarthritis. Its co-localisation with matrix metalloproteinase 3 and 9, previously reported to also have pro-angiogenic roles, may be linked. Further research is required to understand these roles more fully.


P13 Pages 373 - 373
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ABSTRACT WITHDRAWN


P Polli GW Barrett IE Millais LR Green C Cooper SA Lanham ROC Oreffo P Dolan

Introduction: Intrauterine protein restriction in rats is associated with low bone mass which persists with development through to adulthood. However, such adverse effects are not only restricted to bone. Intervertebral discs are the largest avascular structures in the body, and are particularly sensitive to their nutritional environment. We have examined the hypothesis that changes in the intervertebral disc (or ligaments), as a result of early nutritional compromise, affect the spine’s mechanical properties.

Material and methods: Lumbar spines were removed from 8 sheep (6 male, 2 female: mean age 2.7 yrs) that had received different diets early in their development: two animals received a control diet, three received low protein in utero (IU), and three received low protein both in utero and postnatally (PN). Fifteen motion segments (consisting of two vertebrae and the intervening disc and ligaments) were dissected from the spines and tested on a hydraulically-controlled materials testing machine. Compressive stiffness and bending stiffness were measured before and after creep loading, in both flexion and extension. Reflective markers attached to the specimens were tracked during loading, enabling intervertebral angles to be calculated. Bending moment-angular rotation curves were used to calculate bending stiffness. Repeated measures ANOVA was used to test for differences in stiffness with posture and creep, and between the dietary groups.

Results: Compressive stiffness increased after creep loading (p=0.002) but was unaffected by posture or dietary group. In contrast, bending stiffness was unaffected by creep but differed significantly between groups and with posture. When compared to controls, bending stiffness in the IU group was reduced by 35% in flexion and 26% in extension (p< 0.02). In the PN group, reductions of 28% in flexion and 15% in extension were observed (p=0.056).

Discussion: These results indicate that early protein restriction can affect the mechanical properties of the spine. These effects were evident in bending but not in compression, and tended to be greater in flexion than extension. These preliminary findings suggest that early protein restriction may affect the composition and mechanical function of the annulus fibrosus and the intervertebral ligaments which are the structures most involved in resisting flexion movements.


I Pountos T Georgouli S Perry J Morley PV Giannoudis

Purpose: Growth factors are released and circulate in peripheral blood after fracture. The purpose of this study was to characterize the early systemic release of several growth factors following accidental fractures and surgery.

Methods: 14 patients (8 male and 6 female) suffering from lower limb long bone fractures were prospectively included in the study. The mean age was 34 years (range 18-61). In all patients the time from fracture occurrence till operation was less than 24 hours. Peripheral blood samples were collected on patients’ admission, induction, and postoperatively at 1, 3 and 5 days. Serum was extracted and using Elisa colorimetric assays the concentration of Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF), Insulin-like Growth Factor I (IGF-1) and Transforming Growth Factor beta 1 (TGF-b1) was measured.

Results: From fracture occurrence till induction for surgery a substantial decreased was observed (VEGF concentration was decreased by 189%, PDGF was decreased by 363%, TGF-b1 was decreased by 247 % and IGF-1 was decreased only by 25%. Surgery itself decreased VEGF peripheral levels by a further 50% and PDGF by 40 % while IGF and TGF-b1 levels remained unchanged. During the first post-operative day the levels of VEGF were increased by 82%, TGF-b1 and IGF-1 remained constant and PDGF was further decreased by 20%. Between the 1st and 3rd postoperative days VEGF was increased by 132%, PDGF by 220% and TGF-b1 by 230 %. During this period, IGF-1 was decreased by 20 %. Finally, during the 3rd to 5th postoperative day, the levels of all growth factors continue to increase.

Conclusion: This study illustrates the early pattern of release of 4 growth factors following fractures and surgery. A substantial decreased during the first 24 hours was noted but thereafter an upward trend was observed. This data provide insight into the levels and kinetics of growth factors before and after surgery of fractures.


D Gordon C Pendegrass G Blunn

Introduction: Intraosseous Transcutaneous Amputation Prostheses (ITAP) could overcome the problems associated with conventional stump-socket prostheses for amputees (pressure sores, pain, infections and unnatural gait), by attaching the external prosthesis directly to the skeleton via a skin penetrating abutment. Despite this, the skin breach introduces a potential route for infection. For success, a biological seal at the skin-ITAP interface is essential.

The protein Laminin-5 (L-5) is a ‘biological glue’, which is integral to epitheial cell adhesion. Covalently bonding L-5 to the ITAP titanium alloy (Ti6Al4V), may enhance the strength of the skin-ITAP interface.

Silanisation, a chemical technique that covalently bonds proteins to metals, could be used to bond L-5 to Ti6Al4V. We have assessed the characteristics L-5 silanised Ti6Al4V as a potential substrate for ITAP.

Method: To determine the maximum quantity of L-5 that could be silanised to Ti6Al4V, and its relative stability when soaked in foetal calf serum (FCS) over time; polished Ti6Al4V discs were silanised by immersing in aminopropyltriethoxysilane followed by glutaraldehyde. Radiolabelled rat laminin-5-I125 was then added. Discs were immersed in FCS for 4 days (37 C) and analysed at 24 hour intervals in a liquid scintillation counter. Un-silanised discs were used as controls.

Results: L-5 was successfully covalently bound to Ti6Al4V. 10ng, 100ng, 250ng and 500ng droplets yielded significantly more silanised L-5 (p< 0.05), but no difference was observed between 750ng and 1000ng. Percentage L-5 covalently bound ranged from 33% and 65%.

A small decrease in bound L-5 occurred after 24 hours of FCS soaking (p< 0.05), but subsequent to this no significant reduction was observed for 4 days (p< 0.05). Controls showed a significantly larger reduction after 24 hours (p< 0.05).

Conclusion: Covalently bonding L-5 to Ti6Al4V by silanisation can be achieved with predictable results. Large enough quantities can be immobilised to influ-ence cellular function. L-5 silanised to Ti6Al4V remains stable in vitro over time and is not removed. Following the study of cellular interactions with silanised L-5, a stable skin seal may be achieved at the transcutaneous portion of the ITAP.


TN Board P Rooney PR Kay

Fresh frozen femoral head (FFH) allograft is commonly used in impaction grafting for revision hip arthroplasty and long term success has been demonstrated by some groups. The optimum treatment of the graft prior to impaction has not yet been determined. Some groups wash the graft prior to impaction and others do not. Washing of the graft has been shown to improve bone ingrowth in a bone chamber animal model however the reasons for this remain unclear. The aim of this study was to identify any underlying cellular cytotoxicty of fresh frozen allograft bone before and after washing.

Samples of morcellised FFH allograft were taken during revision hip arthroplasties prior to impaction grafting. Paired samples, taken before and after washing were taken from each case. Washing was performed by 4 consecutive washes in 300ml warmed saline, the bone being filtered between each exchange of saline. Cytotox-icity was assessed for all samples using both contact and extract assays. Contact assays involved culture of cell lines in direct contact with bone samples. Extract assays utilised culture media conditioned with bone samples and subsequent quantitative assessment of cell metabolism and viability using both dimethylthiazol (MTT) and neutral red (NR) assays. All assays were performed using both human osteoblastic (MG63) and fibroblastic (HSF) cell lines.

Nine pairs of samples were analysed for cytotoxicity using both cell lines. Contact assays demonstrated a clear zone of cellular inhibition around the unwashed bone samples. Extract assays were performed in triplicate for each cell type and both MTT and NR assays giving 108 paired assay results. 88.9% of pairs (92/108) showed cytotoxicity in the unwashed sample. No washed samples demonstrated cytotoxicity. When grouped by assay and cell type, analysis of means showed statistically significant differences between washed and unwashed samples in MG63-NR (p=0.0025), HSF-NR (p=0.0004) and MG63-MTT (p=0.008). The difference observed in the HSF-MTT assays did not reach statistical signifi-cance (p=0.06).

In conclusion, we have shown that unwashed FFH allograft can be cytotoxic to human osteoblastic and fibroblastic cell lines in vitro. This suggests that allograft should be washed prior to impaction in order to optimise the biological compatibility.


SV Karuppiah DET Shepherd J McConnachie AJ Johnstone

Introduction: For years traditional intramedullary nails (IMNs) have been used with great success to treat long bone fractures, however, based upon our clinical observations, we hypothesise that design changes incorporated into newer femoral IMNs reduces fracture stability resulting is a higher incidence of non-union.

AIMS: To biomechanically test the factors that may reduce fracture stability.

Materials and methods: The fracture fixation model consisted of custom made stainless steel IMNs of different wall thicknesses and outer diameters, cylinders manufactured from stainless steel, aluminium or HDPE of differing inner diameters and wall thicknesses, and 5mm rods made from stainless steel or titanium. The dimensions of the cylinders were chosen to resemble those commonly observed in the distal femur. The test nails and cylinders were connected using a single rod. Axial loading was undertaken up to 2KN (constant rate of 0.5KN/sec) and repeated a minimum of three times. The effects of various factors such as IM nail wall thickness and outer diameter, the alloy from which the rods were manufactured, and, the diameter, wall thickness and material properties of the cylinders were studied.

Results: The factors that most affected stability were the diameter, wall thickness and the material properties of the cylinders, with the least stable configuration being a HDPE cylinder with a diameter of 75mm and a wall thickness of 3mm. By reducing the diameter of the cylinder to 50mm combined with increasing the wall thickness to 5mm, stability increased considerably even when HDPE was used. The stability of each fracture fixation system was further reduced by using titanium rods.

Discussion: In clinical practice, new femoral IMNs permit longer cross screws to be inserted in the distal femur where the diameter is greatest and the cortical bone is thinnest. Since cancellous bone offers little resistance, screws effectively span from one cortex to the other gaining limited purchase in the bone. As a result, the newer IMN systems are more likely to displace regardless of the direction and force applied. This effect is exaggerated by using titanium. Overall the combination of screw length, choice of alloy and cortical thickness could easily explain our unsatisfactory clinical observations.


BJ Bolland AMR New ROC Oreffo DG Dunlop

Background: Impaction bone-grafting in revision hip surgery generates high forces that may be transmitted through the graft to the femoral cortex, generating high surface strains and a concomitant risk of femoral fracture. Concern of inducing fracture may lead to under-compaction of the graft, with subsequent risk of implant migration. Vibration is commonly used in civil engineering applications to increase aggregate compressive and shear strengths. We have therefore examined the hypotheses that vibration-assisted graft compaction would (a) increase graft compaction compared with the standard femoral impaction grafting technique and subsequently reduce prosthesis migration and (b) reduce femoral hoop strains in the production of graft of a given density and mechanical properties.

Method: Physiological composite femurs were adapted to represent femurs encountered in revision hip surgery by widening of the internal diameter and thinning of the outer shell. In the control group, revision with the standard Exeter technique was simulated using highly washed morcellised bone graft from fresh-frozen human femoral heads. In the study group, vibration-assisted graft compaction was used. The femurs were mounted on a 5kN capacity load cell to measure the total force imparted during graft impaction. Strain gauges placed at the medial calcar and midshaft, measured hoop strains generated during the impaction process. On completion of graft impaction, an Exeter stem was cemented in place. Implant subsidence under physiological cyclic loading (5x 105 cycles) and graft density using micro CT were measured after compaction.

Results: There were no significant differences between the two groups in the peak forces (3.8-4.1kN) imparted during the impaction process. Similar peak hoop strains were observed in the both groups (1.2-1.4%). However a greater graft density was seen in the vibration group with minimal implant subsidence under cyclic loading.

Conclusion: The use of vibration during the impaction process allowed improved graft compaction to be achieved without increasing hoop strains in the femoral cortex. This has implications in preventing failure from under impaction without increasing the risk of fracture. Furthermore, this analysis is applicable to the study of novel synthetic grafts / mixtures in the impaction process for orthopaedic application.


R Wharton JH Kuiper C Kelly

Objective: To compare the ability of a new composite bio-absorbable screw and two conventional metal screws to maintain fixation of scaphoid waist-fractures under dynamic loading conditions. Methods: Fifteen porcine radial carpi, whose morphology is comparable to that of human scaphoids, were osteotomized at the waist. Specimens were randomized in three groups: those in group I were fixed with a headed metal screw, in group II with a headless tapered metal screw, and in group III with a bio-absorbable composite screw. Each specimen was oriented at forty-five degrees and cyclically loaded using four blocks of 1000 cycles, with peak loads of 40, 60, 80 and 100 N, respectively. In case of gross failure the number of cycles to failure was determined. Otherwise, permanent displacement at the fracture site was measured after each loading block from a standardized high-magnification photograph using image analysis software (Roman v1.70, Institute of Orthopaedics, Oswestry). Statistical analysis was by ANOVA and tolerance limits.

Results: Nogrossfailureoccurred. Averagedisplacements after 4000 cycles up to 100N were 0.05mm±0.03SD (headed metal), 0.15mm±0.16SD (headless metal) and 0.29mm±0.11SD (composite) and differed significantly (p< 0.02). Using tolerance limits, the data allowed us to predict that with 95% certainty, displacement in 95% of any sample fixed with a headed metal screw will be below 0.17mm, headless metal screw below 0.84mm, and composite screw below 0.76mm.

Conclusion: Comparing two types of conventional metal screws and a new composite bio-absorbable screw to maintain scaphoid fixation under cyclic loading conditions, we found small average fracture displacements for all three screws. Moreover, even following severe cyclic loading conditions, clinically meaningful displacements of more than 1 mm are highly unlikely for any of the three screws. We therefore conclude that a new bio-absorbable composite screw can serve as an alternative to conventional screws when fixing scaphoid fractures.


A Sittichokechaiwut AJ Ryan G Reilly

Mechanical force is an osteoinductive factor that plays an important role in bone growth and repair in vivo (Carter et al. 1988). Many in vitro studies have shown that osteoblasts and osteocytes respond to mechanical loads such as stretch and fluid-flow induced shear stresses, with initiation of signalling pathways (Reilly et al 2003). The underlying mechanisms by which bone cells respond to mechanical signals are difficult to investigate in a 3-D environment, because of reduced nutrient delivery to cells and difficulties in analysis.

We are developing a model to analyse the effects of mechanical compression on matrix forming osteoblasts in a 3-D system. Our model uses polyurethane (PU) open cell foam scaffolds, MLO-A5 osteoblast-like cells (Kato et al 2001) and a sterile fluid filled biodynamic loading chamber (Bose). We have shown using a cell proliferation assay (Promega) that cells survive well and proliferate in the PU scaffolds. Cell number after 15 days of culture was four times that after 5 days of culture. To examine the effect of mechanical stimulation on osteoblastic cells we seeded MLO-A5, kindly donated by Dr. L. Bonewald, at densities of 125,000 cells per scaffold in PU foam cylinders, 10 mm thick and 25 mm diameter. The cell seeded PU scaffolds were dynamically loaded in compression at 1Hz, 5% strain in a sterile fluid-filled chamber. Loading was applied for 2 hours per day at days 5, 7 and 9 of culture. In between loading cycles, scaffolds were cultured in an incubator in standard conditions.

Preliminary data indicates that the cells survived loading but final cell number was reduced compared to unloaded controls by 30%. However, the scaffold stiffness (Young’s modulus) increased in loaded samples over time (days) which may be an indication of increased matrix production. Fluorescence microscopy indicated that loaded cells were distributed in dense clusters whereas unloaded cells were distributed evenly throughout the scaffold. In conclusion, this model has the potential to answer questions about cell survival, distribution and matrix production in 3-D, in response to mechanical signals.


C Haasper M Colditz C Hurschler J Zeichen C Krettek M Jagodzinski

Introduction: Homogenous cell distribution and suffi-cient initial scaffold stability remain key issues for successful tissue engineered osteochondral constructs. The purpose of this study was to investigate the application of initial compression forces during the first 24 hours of cell culture followed by different stress patterns.

Methods: Bone marrow stromal cells were harvested from the iliac crest during routine trauma surgery. The cells were expanded in a 2-dimensional culture and then seeded into the biologic hybrid scaffold with a concentration of 1x10E6 cells per ml. Pressure and vacuum forces were applied in a specially developed glass kit. The constructs were exposed to two different protocols of compression combined as oteochondral matrices of CaReS (collagen I) and Tutobone (Ars Arthro, Esslingen, Germany and Tutogen Medical GmbH, Neunkirchen a. Br., Germany). Controls were resected osteochondral fragments from patients with articular fractures and uncompressed constructs. These effects were evaluated using light microscopy after standard staining to identify matrix penetration. Biomechanical tests were conducted, too using a modified biomechanical testing machine. The ‘constrained compression’, maximum load to failure, modulus, and strain energy density were determined.

Results: Histology: Penetration and cell distribution was demonstrated homogenous and vital, respectively. Mechanical tests showed a significant enhancement of primary matrix stability. The following stress patterns did not enhance significantly stability over seven days.

Discussion: The aim of this project was to investigate the response and cell distrubution of human bone marrow stromal cells seeded on a 3-dimensional biologic hybrid scaffold using compression and vacuum forces.

The integration of mechanical stimulation in the tissue engineering process may lead to a progress in the structural and biomechanical properties of these tissues and offers new possibilities in the management of bone injuries and degenerative diseases.


SM Sarasin A Reeves E Maylia

Reamed, locked intramedullary nailing is the treatment of choice for many long bone fractures, be them open or closed injuries. Certain nails used can be inserted without any locking component or reaming. However, the most biomechanically sound fixation is achieved with a reamed, locked nail, and this therefore is the preferred construct. The process of reaming is not without complication, however. Pulmonary complications secondary to embolization of intramedullary contents are of the most concern. The formation of emboli is believed to be a direct result of raised intramedullary pressures created largely by the reaming process, although nail insertion does also play a part.

The magnitude of intramedullary pressures generated during the reaming process is due, in part, to the design of the reamer itself. This study compares four different reamers currently in use in NHS hospitals today. The reamersusedincludeanolderdesign(AOUniversal(TM)) and three newer designs (Synthes Synream(TM), Biomet 5+(TM) and Stryker Bixcut(TM)).

Four different reamer head sizes were used- 9.5mm, 11.5mm, 13.5mm and 15.0mm. These were tested in vitro using a Vaseline(TM)/paraffin oil mixture to simulate intramedullary tissue and Perspex(TM) tubing of varying sizes to simulate a long bone with an intramed-ullary cavity.

The results showed that the older generation reamer produced consistently higher pressures than the newer designs of reamer with statistical significance. All the newer generation reamers produced similar pressure magnitudes, although the Biomet 5+(TM) tended to produce the lowest pressures with some statistically sig-nificant differences.

This study shows that different designs of reamer can generate different pressures and that the newer generation of reamers do produce lower pressures. This is therefore important in the prevention of complications associated with reaming and intramedullary nailing.


AP Rumian AL Wallace HL Birch

Tendons and ligaments are similar in composition but differ in function. Simple anatomical definitions do not reflect the fact individual tendons and ligaments have unique properties due to their adaptation to a specific role. The patellar tendon is a structure of particular clinical interest. A null hypothesis was declared stating that the patellar tendon is not significantly different in terms of matrix composition and collagen fibril diameter to other tendons.

The lateral and medial collateral ligaments (LCL, MCL), anterior and posterior cruciate ligaments (ACL, PCL), together with the long digital extensor, superfi-cial digital extensor and patellar tendons (LDET, SDFT, PT) were harvested from 3 cadaveric ovine hindlimbs. The extracellular matrix was assessed in terms of water, collagen and total sulphated glycosaminoglycan (GAG) content. The organisation of the collagen component was determined by an ultrastructural analysis of collagen fibril diameter distributions using electron microscopy, together with values for the collagen fibril index (CFI) and mass-average diameter (MAD).

There were significant differences between ligaments and tendons. The PT had a bimodal collagen fibril diameter distribution with CFI72.9%, MAD 202nm, water content 53.1%, GAG content 2.3 g/mg and collagen content 73.7%, which was not significantly different from the other tendons.

The results of this study support the null hypothesis suggesting that the patellar tendon is similar to other tendons and demonstrate that tendons have different characteristics to ligaments.


KY Wong N Zant J Tong

Multiple biological and mechanical factors may be responsible for the failure of fixation in cemented total hip replacements (THRs). Although the eventual failure of THRs may appear to be biological, the initiation of the failure during early period post operation may well be mechanical. It is in this area that mechanistic analysis is of particular significance.

This study builds on work by Rapperport et al, Dals-tra and Huiskes on stress analysis of implanted acetabulum, while focuses on fracture mechanics analyses of fracture of cement and of bone-cement interface. Specifically, finite element models were developed where cracks of most favourable orientations in the cement mantle were simulated. Possible crack path selections were explored. A simplified multilayer experimental model was also developed to represent the implanted acetabulum, and fatigue tests were carried out on the model. The experimental results were compared with those from the FE model.

Furthermore, interfacial crack growth at bone-cement interface was simulated from the superior edge of the acetabulum, as suggested from the clinical observations. The strain energy release rates were computed for typical hip contact forces during gait and as a function of crack length. Associated phase angles were also computed to account for the materials mismatch. The results were evaluated against the interfacial fracture toughness of the bone-cement interface, measured using sandwich Brazilian disk specimens. The results show that although interfacial fracture seems to be unlikely for large phase angles where shear component is most active, the strain energy release rates are comparable with the values of the interfacial fracture toughness when mode I is predominant, suggesting interfacial fracture.

The study also shows that the fracture toughness of cement is much higher than the interfacial fracture toughness of bone-cement, this may explain the reason why interfacial fracture is favoured even if the crack driving force at bone-cement interface appears to be weaker than that in the cement mantle.


MC Quaye CT Reynolds KE Tanner J B Mitchell S Owen-Johnstone

Two stainless steel ‘TriMed’ distal radial fracture reduction techniques were tested to compare the relative stability of the two in vitro for a pre-determined fracture pattern. The movement of the bony segments were plotted over time using an ARAMIS 3 dimensional non-contacting displacement mapping system (GOM mbH, Braunschweig, Germany) to give quantitative data. The data was used to calculate the relative motion of the bony segments with the aim of investigating regions of compression across the fracture line, which is thought to accelerate fracture healing, and shear between bony segments, which is detrimental to fracture healing.

Ten third generation adult radius biomechanical model Sawbones (Sawbones, Malmö, Sweden) were cut to simulate AO type C2 fractures with dorsal comminution. Five bones were plated using the TriMed fixed angle volar bearing plate and five were plated using the TriMed radius and ulnar plating technique. Samples were potted and loaded cyclically at 1 Hz via a floating scaphoid-lunate bearing onto the end of the radius at incrementally increasing loads of 100 N – 500 N with 1000 load cycles applied for each load level.

The results showed the radius and ulnar pin-plate configuration allowed greater movement of the articular surface, with relative shear motion and separation between the two segments, although the relative shear movement between the two distal segments was below 2mm, which is considered the definition of failed fixa-tion. With the volar bearing plate the two distal segments moved as single unit and compression with minimal shear was applied across the fracture line to the proximal radius. Thus the radius and ulnar plates allowed shear across all three fracture lines, while the volar plate held the two distal segments fixed relative to each other and allowed compression across the interface with the proximal radius. The ARAMIS system allowed the three dimensional motion of the bony segments to be followed, in particular the relative motion between the segments, indicating the type of healing to be expected clinically. The study demonstrated the value of ARAMIS in investigating the stability of wrist fractures fixations and can easily be adapted to investigate other orthopaedic fixation systems.


A Atrey J Compson P O’Higgins

The aim of this study was to discover if the ulnar styloid is sufficiently consistent in size, shape and position relative to other bony features of the ulna to be used as a reference in pre-operative planning of fixation of broken bones.

The comparison of size and shape (together known as form) between bones has recently been facilitated thanks to the advance of technologies designed to allow the comparison of the form of structures using anatomical landmarks.

This new class of methods is collectively known as geometric morphometrics. It eliminates the differences in location and rotation of landmark through registration that minimises the sum of squared deviations from each other after scaling. This is Procrustes registration. The residual size and shape information is amenable to statistical analysis. In the present application, the registered Procrustes landmarks are used to compute a mean (reference) shape. The individuals are then compared to this mean/ reference shape. Using principal components analysis (PCA) variations in shape are not only identi-fied, but also quantified. The identification of patterns of deviation from the mean shape is considerably enhanced through the use of 3-D visualistaions of the shape variations represented by the space of the PCA.

These analyses indicate that the ulnar styloid is suf-ficiently consistent in location to other anatomical landmarks that it could be used as a radiographic marker in preoperative planning.

More importantly, the analysis of this study indicates that the methods of geometric morphometrics are widely applicable to the analysis of 3-D variations in morphology facilitating the analysis and comparison of radiographs. A useful future application will be in the development of 3-D reference morphologies that will allow the surgeon to compare and contrast the morphology of a radiograph of a badly broken (comminuted) bone to a standard one. Eventually computer might assist the surgeon by geometrically and visually showing how and by how much the bone needs reduction. Similarly, applications to the the virtual comparison of diseased and healthy bones might allow quantative and visual comparisons that could aid diagnosis and planning.


A Jariwala A Azhar RJ Abboud C A Wigderowitz

The pattern of injury to the carpal ligaments following wrist trauma is unclear. Different imaging techniques often prove inconclusive rendering the diagnosis difficult and hence the treatment controversial. This study aimed to observe and evaluate the differences in scapholunate kinematics before and after sectioning the scapholunate interosseous ligament (SLIL) and radioscaphocapitate ligament (RSC).

Twenty two embalmed cadaveric wrists were used. There were four males and seven females with an average age of 84 years. Their medical records confirmed the absence of previous history of wrist diseases or injuries. The extensor and flexors tendons of the wrist were removed leaving the capsule intact. Two drill bits (1.5 mm) were used to make a hole each in scaphoid and lunate, one centimeter apart. The drill bits were left in the bones to act as metal wires for calibration. Each wrist was moved through a set of motions and each movement was performed thrice; first one with the ligaments intact, second with SLIL sectioned and the last one with RSC excised. Digital photographs were taken and angles measured with MB Ruler software. Analysis of variance was done using SPSS 12.

There was no angle between the metal pointers when the ligaments were intact. There was movement and change in angle detected when SLIL and RSC were sectioned. The sectioning of the SLIL lead to a significant increase in the angle between the pointers in all the movements recorded (p value < 0.001). Subsequent sectioning of the RSC further increased this angle but this increase was much smaller compared to that after sectioning SLIL. On completion of the measurements the wrist capsule was opened to reveal that both the ligaments had been successfully sectioned and there were no degenerative changes in the bones or ligaments in any wrist.

This first cadaveric evaluation of alterations in scapholunate motion with sectioning of SLIL and RSC revealed that SLIL has a significant influence on the scapholunate kinematics, where as sectioning of the RSC has little additional effect. This in-vivo finding might have implications of importance of preserving SLIL during wrist surgeries and its role in management of carpal instabilities.


FR Harrold F Park-Wesley R Abboud C Wigderowitz

Introduction: Successful shoulder arthroplasty is based on restoration of the individual’s proximal humeral morphology with a precise osteotomy of the humeral head at the level of the anatomical neck. The objective of this study was to determine the geometry of the articular portion of the humeral head in contact with the glenoid in the neutral position and compare the orientation to the geometry of the humeral head determined using the cartilage/calcar interface of the anatomical neck.

Methods: An intact rotator cuff and joint capsule were exposed for six cadaveric full arms. Precision perspex reference cubes were attached to the greater tuberosity of the humerus and to the coracoid process of the scapula on each specimen. Each shoulder was mounted in a custom built jig with the arm fixed in the neutral position and a Microscribe 3D-X digitizer used to digitize three faces of each precision cube. The shoulder joint was then disarticulated and both the humerus and scapula re-mounted on the same jig, independently. The cube faces were re-digitized and relevant points, lines and surfaces were identified and digitized on each humerus and scapula. The humeri were then scanned using a high precision surface laser scanner.

The data collected from both digitizing tools were merged into the same coordinate system and graphically represented. Paired Student’s t-tests were used to compare the inclination and retroversion angles for the two techniques.

Results and discussion: The study found a significant difference in inclination (p less than 0.02) and no difference in retroversion (p equal to 0.75) when the glenoid position was used to calculate humeral head orientation (Inclination: Mean 11.5 deg., StD. 11.2 deg.; Retroversion: Mean 20.5 deg., StD. 6.6 deg.) when compared to using the cartilage/calcar interface (Inclination: Mean 134.1 deg., StD. 1.9 deg.; Retroversion Mean 21.7 deg., StD. 13.9 deg.).

Small deviations in the recovery of head orientation in shoulder arthroplasty may impact on the longevity of an implant. The differences in inclination and retroversion noted in this study may alter the load on the glenoid and/or rotator cuff mechanism in joint replacement. Further research is necessary.


ATM. Phillips P Pankaj CR Howie AS Usmani AHRW Simpson

Previous experimental studies of the pelvis have been carried out on cadaveric samples stripped of soft tissue. Investigations of the stress concentrations present in the pelvis due to the application of force through the hip joint have been conducted with the superior iliac crests cast in resin or cement. Thus stress concentrations are observed towards the superior iliac crests, and to some extent the pubic symphysis (these being the areas in which force transfer can occur). Due to the rigid fixing of the pelvis in these experiments, the pelvic bone has become viewed as a ‘sandwich beam’ acting between the sacro-iliac and the pubic joints. Numerical models employing similar fixed conditions have shown good agreement with the experimental studies.

However it is clear that these experiments, and the accompanying computational models are not representative of the in-vivo situation, in which the muscles and ligaments of the pelvis and hip joint provide resistance to movement, and in the case of muscles place additional forces on the pelvis, not addressed in the experimental studies. This study presents a finite element model of the pelvis in which novel techniques have been used to include the pelvic ligaments, and hip joint muscles using realistic attachment areas on the cortex, providing a more realistic comparison to the in-vivo environment. Joint interactions at the pubic symphysis and sacro-iliac joints are also simulated. A fixed boundary condition model is also presented for comparison.

The resulting stress concentrations in the pelvis for single leg stance observed in the in-vivo boundary condition model are dramatically different to those presented in studies in which the pelvis is rigidly fixed in place. The abductor muscles are seen to play a significant role in reducing stress concentrations towards the sacro-iliac joints and superior to the acetabulum, in comparison to fixed boundary condition analyses. Stress reductions away from the acetabulum are also observed in the underlying trabecular bone for the in-vivo boundary condition model. Similar stresses are observed within the acetabular region for the fixed, and in-vivo boundary condition models.


M Bhattacharyya B Gerber

Malpositioning of the component of a total knee implant and malalignment of the leg is one of the significant factors for the outcome after Total Knee Arthroplasty.

Previous studies have shown that the use of a navigation system can improve these. This article presents the initial results of a prospective and non-randomised study describing navigated implantation in TKA with special reference to soft tissue balancing in knees with posttraumatic deformity. The secondary objective is to found out reproducibility of the software.

Methods: Since January 2004, 15 patients with post-traumatic arthrosis of the knee and axial malalignment of more than 15 degrees, pre operative arc of motion 75 degrees admitted to our senior author for TKA have been followed up prospectively. The data were collected over a period of 25 months. Apart from the usual clinical evaluations, no patients had CT of the leg prior to the operation & postoperatively. Intra-operative and peri-operative morbidity data were collected and blood loss measured.

Results: A postoperative leg axis between 3 degrees varus and 3 degrees valgus was obtained in all of the navigated knees after soft tissue balancing. The alignment of the components using computer-assisted surgery in regard to femoral varus/valgus, femoral rotation, tibial varus/valgus, tibial posterior slope, tibial rotation are reproducible and consistent. Computer-assisted surgery took longer with a mean increase of 31 minutes for kinematic data acquition. Intraoperatively we achieved range of motion more than 120 degrees. No patient required manipulation postoperatively for improving range of motion

Conclusion: These results support that the precise surgical reconstruction of the mechanical axis of the knee and proper alignment of the component is achievable in patients who suffered posttraumatic deformities and secondary arthrosis by using an intraoperative navigation system.

It has been mentioned in the literature that minor deviations in the insertion point of Intramedullary instrumentation during TKA may result in malalign-ment of several degrees [Nuno-Siebrecht 2000], which can be avoided with these soft ware.


JCJ Webb S Gheduzzi RF Spencer ID Learmonth

The visco-elastic behaviour of acrylic bone cement is a key feature of cement-implant performance. The ability of the cement to creep in conjunction with a force-closed design of stem (collarless polished taper) affords protection of the vital bone-cement interface. Most surgeons in the UK use antibiotic-laden PMMA in primary total joint arthroplasty. In revision surgery the use of bespoke antibiotic-cement combinations is common.

The aim of this study was to elicit the effect of antibiotics upon the physical properties of bone cement.

Methods: The static properties of the cements were assessed following protocols described in ISO 5833: 2002, while the viscoelastic properties of the cement were measured with in-house developed apparatus in quasi-static conditions. Creep tests were performed in four point bending configuration over a 72 hour period in physiological conditions. Porosity was measured on the mid cross section of the creep samples using a digital image technique.

The cements used were Palacos R40 and Palacos R with gentamicin. The antibiotics added included fucidin, erythromycin, teicoplanin and vancomycin in 500mg powder aliquots up to a maximum of 1g per 40 g mix.

All data were analysed using ANOVA with Bonfer-roni post-hoc test. Pearson’s correlation coefficient was used to investigate the association between physical factors (SPSS).

Results: The static and working properties did not vary significantly with antibiotic additions. The mean creep of the cement increased in line with the amount of antibiotic added. The specific antibiotic was not relevant. The differences were statistically significant. Mean porosity also increased with antibiotic mass. There was a linear relationship between cement porosity and creep!

Conclusions: Despite modern mixing techniques the porosity of bone cement increases with antibiotic additions. This increased porosity is related to the greater creep seen in the cement. Surgeons should apply these findings when planning revision hip surgery.


D Skrzypiec P Pollintine A Przybyla T Dolan M Adams

Introduction: Vertebral bodies and intervertebral discs resist most of the compressive force acting on the spine. However, experiments on lumbar spines have shown that apophyseal joints can resist more than 50% of applied compression, and that the proportion varies with spinal level, disc narrowing, and posture. In the cervical spine, the situation is likely to be complicated by the presence of uncovertebral joints on the lateral margins of the disc. Load-sharing is important because it influences injury risk, and predisposition to degenerative changes. The present study aims to characterise compressive load-sharing in the cervical spine.

Methods: Sixteen cervical motion segments, consisting of two vertebrae and the intervening disc and ligaments, were dissected from nine cadaveric spines, aged 48-77 yrs (mean 63 yrs) which had been stored at -17degC. Specimens were subjected to 200N of compression while the distribution of compressive ‘stress’ was measured along the mid-sagittal diameter of the disc, using a pressure transducer side-mounted in a 0.9mm-diameter needle. ‘Stress profiles’ effectively were integrated over area to calculate the total compressive force acting on the disc. Experiments were performed with each specimen in flexion, extension and neutral posture. They were repeated after creep compressive loading (2 hrs at 150N) to simulate diurnal loading in life, and again following removal of the apophyseal joints. Eight specimens were re-tested following bi-lateral removal of the uncovertebral joints.

Results: Creep loading reduced disc height by an average 0.64mm (approximately 12%). Creep reduced overall computed disc loading by 14% and 25% in neutral and extended postures respectively (P< 0.005). Apophyseal joint removal increased disc loading in extension (only) by 14% (P< 0.05). Uncovertebral joint removal further increased disc loading in flexed, neutral and extended postures by 28%, 33% and 21% respectively (P< 0.05).

Conclusion: Creep loading of the cervical spine transfers loading to the apophyseal joints and uncus. The former effect is small, and significant only in extended postures. The latter effect is larger, and is greatest in flexed and neutral postures.


ATM Phillips P Pankaj CR Howie AS Usmani AHRW Simpson

Following hip arthroplasty carried out using the Slooff-Ling impaction grafting technique micro-motion of the acetabular cup is frequently seen within the bone graft bed. In some cases this can lead to gross migration and rotation of the acetabular cup, resulting in failure of the arthroplasty. The movement of the cup is thought to be due to the irrecoverable deformation of bone graft under shear and compressive forces. Previous experimental studies have addressed ways in which the behaviour of the bone graft material may be improved, for example through washing and the use of improved particle size distribution. However there has been a limited amount of research carried out into assessing the behaviour of the acetabular construct in-vivo.

This study presents a 3D finite element model of the acetabular construct and hemi-pelvis following impaction grafting of a cavitory defect. A sophisticated elasto-plastic material model was developed based on research carried out by the group to describe the bone graft bed. The material model includes the non-linear stiffness response, as well as the shear and consolidation yield response of the graft. Loading associated with walking, sitting down, and standing up is applied to the model. Distinct patterns of migration and rotation are observed for the different activities. When compared in a pseudo-quantitative manner with clinical observations results were found to be similar. Walking is found to account for superior migration, and rotation in abduction of the acetabular cup, while sitting down and standing up are found to account for posterior migration, and lateral rotation. The developed 3D model can be used in the assessment of cup designs and fixation devices to reduce the rate of aseptic failure in the acetabular region.


P Buddhdev AJ Hart P Tarassoli J Skinner

Background: Metal-on-metal bearing hip replacements release between three and nine times more cobalt and chromium ions than a metal on polyethylene bearing hip replacement. We do not fully understand the cause for the variability of ion levels after metal on metal hip replacement. The factors that determine an individual’s levels of metal ions include: firstly, patient factors (renal failure, patient weight, high activity); secondly, manufacture factors (head size (and fluid film lubrication), carbide density, surface finish) and lastly study factors (bilateral implants, time from operation). Biomechanical studies suggest that component position, in particular acetabular inclination, is important for wear rate but there is no published correlation from clinical studies.

Aim: To investigate the relationship between acetabular inclination angle and metal ion levels of patients with Birmingham Hip resurfacings.

Methods: Using standardised radiographs, we measured the inclination angle (using UTHSCSA image tool) of the acetabular components in thirty-one patients (mean age 54 years) who underwent unilateral Birmingham hip resurfacing (mean time post operation of 22 months). We also measured peripheral whole blood chromium and cobalt ion concentrations using inductively coupled mass spectrometry. All components were well fixed.

Results: There was a positive correlation between the inclination angle (range 28 degrees – 55 degrees) of the acetabular component and whole blood concentration of Cobalt (range 2.3 – 7 mcg/L), Chromium (range 0.56 – 4.3 mcg/L) and total metal ion levels (range 3.1 – 10.3 mcg/L). This finding was statistically significant, with a Pearson correlation coefficient of 0.46 (95% CI 0.13-0.70) and a p-value of 0.00398.

Conclusion: Acetabular inclination angle is likely to be a factor in determining an individual’s metal ion levels in patients with metal on metal resurfacing. We also iden-tified a threshold level of 50 degrees inclination, after which the metal ion levels rise dramatically. We describe the possible biomechanical mechanisms to explain these results. We recommend surgeons implant the metal socket at an inclination angle of less than 50 degrees.


P Heaton-Adegbile JG Hussell J Tong

Objective: To examine the effect of varying the thickness of the cement mantle on the strain distribution near the bone-cement interface.

Background: An insufficient cement mantle is thought to generate cement fractures near the bone-cement interface. Debonding at the bone-cement interface may accompany such fractures, and, mechanical failure of the prosthesis may follow. In this study, we aim to analyse the relationship between the cement mantle thickness and the acetabular strain distribution near the bone-cement interface.

Experimental model: Four hemi-pelvic saw bones specimens were implanted with six protected precision strain gauges. All specimens were prepared to receive a 53/28 cemented polyethylene cup (Depuy Charnley Elite).

Methods: We simulated hip joint force relative to the cup during normal walking for quasi-static tests on an Instron 1603 testing machine. The magnitude of the maximum and minimum principal strains, and the orientation of the maximum principal strains were calculated based on the readings of strains from a 32 channel digital acquisition system.

Results: Statistically significant differences in the total strains per gait cycle (p< 0.001) have been noted at all gauge locations. In the principal load bearing quadrants, the recorded tensile strains are reduced by 50% as a result of the thicker mantle, while the transmission of compressive strain is enhanced.

Conclusion: A cement mantle thickness of 5-6mm may preserve the structural integrity of the principal load bearing quadrants of the acetabulum better than a mantle thickness of 2-3mm, by minimising the acetabu-lar strains. This maybe desirable in total hip replacements for conditions such as rheumatoid arthritis and osteoporosis, where the poorer quality bone can be assisted by recruitment of a larger surface area to participate in load bearing.

Keywords: Principal strains; Cement mantle; Mantle thickness; Bone-cement interface; Acetabular strains.


M Khan JH Kuiper JB Richardson

In-vitro studies have shown that wear rates of the metal on metal (MOM) bearing hip prostheses decline once the bearing runs-in and the bearing subsequently enters a steady state wear phase. Baseline cobalt levels are thus expected to decline with time in patients. Several clinical studies have not found such a decline. Baseline cobalt levels are hence limited in their capacity to provide information on the wear performance of the bearing couple. We have demonstrated in a previous study that exercise causes a rise in plasma metal ion levels in patients with MOM bearing hip replacement. Would the exercise related cobalt rise be more sensitive to detect change in wear behaviour of the bearing couple? We tested the alternate hypothesis that exercise related rise in the plasma cobalt levels will correlate inversely with the duration of MOM implantation.

Sixteen patients with three different well functioning MOM bearing hip replacement [two types of resurfacing (BHR, Cormet) and Metasul] were included into the study. Patients were divided in to two groups based on time since implantation, an early group of mean 18 months and a late group of mean 57 months. Plasma levels of cobalt were measured before (baseline) and after 1 hour of maximal exercise (peak). The difference between baseline and peak for each patient provided the exercise related cobalt rise. A significant increase in plasma cobalt levels of 13% was noticed after the exercise (p < 0.005). Baseline Cobalt levels in the late group (53nmol/l) were higher than early group (44nmol/l) but the difference was not significant (p=0.45). However, the mean exercise related Cobalt rise levels was lower in late group (3.5nmol/l) than the early group (6.5nmol/l). This lower rise in cobalt level in the late group precisely reflects on the steady state wear as seen in in-vitro tests.

Baseline cobalt levels are limited in determining the in-vivo performance of the bearing couple. Exercise related rise in cobalt levels can differentiate the running in and steady state wear phases of metal on metal bearings and is thus a more accurate tool of assessing in-vivo wear performance of the bearing couple.


VM Budnar GC Bannister

Background: Inadequate proximal femoral pressures obtained during a cemented, primary hip replacement may lead to poor stem fixation. Proximal occlusion during stem insertion,may help in achieving a uniform and sustained rise in intra-medullary pressures, distally and proximally. High intra-medullary pressures correlate with better cement penetration and increased cement-bone interface push-out strength.

Methodology: An In-vitro analysis of femoral pressures was performed. A femoral medullary cavity was created in plaster of Paris constrained in an aluminium cylinder. Intramedullary pressures were measured via pressure transducers. High viscosity bone cement (Palacos-R) was gunned into the medullary cavity. No.3 Exeter stem was inserted with no proximal occlusion, with thumb occlusion over the calcar and with the Exeter Horse-collar. Experiments were repeated by delaying the timing of insertion and with lower viscosity cement (Simplex-P). A small series of experiments were done to ensure that that the stem insertion was performed at standard cement viscosity. The experiments were carried out with the same viscosity of Palacos-R at 4 minutes and Simplex-P at 6 minutes. Palacos-R at 4 minutes 30 seconds had a higher viscosity.

Results: A total of 54 experiments were performed. Of these 18 experiments were done with Palacos R cement, with the stem inserted early on in the curing phase and 18 with a delayed time of insertion. The last 18 experiments were performed with Simplex P cement with the stem inserted early on in its curing phase.

Intramedullary pressures were better in all zones, for all cement modes, with proximal occlusion. The highest pressures were seen with Palacos-R at 4 minutes 30 seconds with proximal thumb occlusion. Stem insertion into Palacos-R at 4 minutes or 4 minutes 30 seconds, gave higher pressures than Simplex-P, with or without any form of occlusion. With Simplex-P, intramedullary pressures were higher, with Collar rather than thumb occlusion.

Conclusion: Occluding the medial cal car area during stem insertion, is an effective way of achieving and sustaining high-pressures in the proximal and distal femur. The highest pressures are obtained with stem inserted into Palacos-R at 4 minutes 30 seconds, with proximal thumb occlusion. Collar occlusion may be better in achieving higher pressures, with lower viscosity, Simplex-P.


BH Van H Pandit J Gallagher HS Gill AB Zavatsky DT Shakespeare DW Murray

Introduction: Restoration of predictable and normal knee kinematics after a TKR can improve the patient’s function. Traditional designs exhibit grossly abnormal kinematics with the femur subluxing posteriorly in extension and a paradoxical forward slide in flexion. In addition, the kinematics are very variable. Newer designs were intended to overcome these problems, owing to their ability to provide ‘guided motion’ of the components. The medial pivot knee uses a specifically designed articulating surface constraining the femoral component to externally rotate about an axis through the medial compartment.

This study assesses the functional in vivo kinematics of Advanced Medial Pivot (AMP) TKR and compares it to kinematics of the normal knee.

Methods: Thirteen patients with pre-operative diagnosis of primary osteoarthritis, who had undergone a knee replacement with the AMP knee at least one-year prior were recruited in this study. All had an excellent clinical outcome (as assessed by AKSS) and underwent fluoro-scopic analysis whilst performing a step up activity. Knee kinematics were assessed by analysing the movement of the femur relative to the tibia using the Patella Tendon Angle (PTA) through the range of knee flexion. This data was compared to that of thirteen normal knees.

Results: The PTA for the normal knee has a linear relationship with knee flexion. The PTA is 14 degrees in full extension and decreases to -10 degrees at 100 degrees knee flexion during a step-up exercise. Between extension and 60 degrees of knee flexion, no significant difference was found between the PTA for the normal knee and for the AMP. The PTA for AMP is significantly higher for values of knee flexion exceeding 60 degrees. The standard deviation for different values of knee flex-ion is similar to that seen in the normal knee.

Conclusions: In extension, the PTA is near normal but in flexion PTA is higher than normal suggesting that the femur is too anterior. The variability of the kinematics for AMP TKR is similar to that of the normal knee and is better than that of most other knee designs that we have studied in the past, indicating that it is a stable TKR.


P Pollintine B Offa-Jones P Dolan MA Adams

Introduction: Atraumatic vertebral deformity could possibly arise from sustained loading by the adjacent intervertebral discs, especially when discs are degenerated and press unevenly on the vertebra (1). Creep phenomena have been studied in samples of cancellous and cortical bone, but little is known about their potential to deform whole bones. We hypothesise that sustained asymmetrical loading of a vertebral body can cause differential creep, and vertebral deformity.

Materials and methods: Five thoracolumbar ‘motion segments’ (two vertebrae with intervening soft tissues) were dissected from human cadavers aged 64-88 yrs. Each specimen was subjected to a 1.5 kN compressive force for 2 hrs, applied via plaster moulded to its outer surfaces. Specimens were positioned in 2 deg flexion to simulate a stooped posture. Six reflective markers were attached to pins inserted into the lateral cortex of each vertebral body. Anterior, middle and posterior vertebral body heights were measured at 1 Hz to an accuracy of 7 microns, using a MacReflex 2D optical tracking device. This enabled elastic and creep strains in the vertebral cortex to be plotted against time. Compressive ‘stress’ acting vertically on the vertebral body was quantified by pulling a miniature pressure transducer along the mid-sagittal diameter of adjacent discs (1).

Results: Maximum elastic compressive strains in the posterior, middle and anterior cortex were 500-700, 800-2000 and 600-2500 microstrains respectively. Corresponding creep strains were 200-1500, 200-3200 and 500-5500 microstrains. Increased strains in the anterior vertebral body corresponded to increased stresses in the anterior annulus of adjacent discs. Creep was greater in older specimens, and was only partially reversible. ‘Permanent’ anterior wedging of the vertebral body could reach 0.7 deg after 2 hrs.

Discussion: These preliminary results suggest that vertebral deformity in-vivo can arise by creep mechanisms, when total (elastic+creep) strain locally exceeds the yield strain of bone (2). Future experiments will consider the middle vertebra in three-vertebra specimens.


J Chu D Skrzypiec P Pollintine M Adams*

Introduction: ‘Stress profilometry’ involves pulling a pressure transducer through a loaded intervertebral discs in order to characterise the intensity of loading within it. The technique has been used to explore how stress distributions vary with age, spinal level, degeneration, creep loading, and injury. However, can the output of the strain-gauged transducer (which is calibrated in a fluid) really quantify stress perpendicular to its membrane when inserted into the fibrous matrix of degenerated discs?

Methods: Thirteen full-depth cylinders, 7mm in diameter, were cut from inner, middle and outer regions of the anterior and lateral annulus of two human upper-lumbar discs aged 74 and 82 yrs. Specimens were confined within a metal cylinder of internal diameter 7 mm. Two vertical slots on opposite sides of the metal cylinder allowed a pressure transducer, side-mounted near the tip of a 0.9 mm-diameter needle, to be pulled through the annulus sample. Constant compressive loading was applied for 20s to the top of the annulus sample, using a plane-ended 6.9 mm-diameter indenter, while the transducer was pulled through the sample. Transducer output was sampled at 25Hz. ‘Stress profiles’ were repeated with the transducer orientated vertically and horizontally, and with 6-21 values of compressive load, corresponding to stresses up to 3MPa. Average values of measured ‘stress’ were compared to applied stress (compressive force/indenter area).

Results: Measured (average) vertical compressive stress was linearly related to applied stress, with Rsq values averaging 0.97. The gradient of the line averaged 0.98 (range 0.77 – 1.28) indicating that measured stress values approximated to applied stress, and were not merely proportional to it. For horizontal measurements, the Rsq and gradient averaged 0.97 and 0.92 respectively. Abnormal results in 3/13 specimens appeared to be affected by transducer damage and were disregarded.

Conclusion: Stress profilometry can quantify compressive stress within the annulus of degenerated intervertebral discs. This fibrous tissue appears to be sufficiently deformable to allow efficient coupling of stress between the matrix and transducer membrane.


A. Jariwala I Scott GP Arnold RJ Abboud CA Wigderowitz

Dynamic assessment of the wrist motion and the specific angles are difficult using the conventional methods. We wanted to adapt and assess the repeatability of the Fas-trak system for continuous monitoring of three dimensional (3 D) wrist movements.

Twenty seven volunteers, aged 18 to 30 years were asked to perform predetermined tasks. The exclusion criteria were previous history of wrist trauma or joint disease. The transmitter was mounted on the dorsum of the forearm while the sensor was placed over the third metacarpal head. The protocol of three tasks was developed. Task 1 measured maximal flexion, extension, radial and ulnar deviation of the wrist. Task 2 involved picking up an object and moving it across a barrier. Task 3 involved the writing simulation. The comparison between the left and the right wrists indicated suitability of the system to be used on either of the limbs. Repeated measurements on the right wrist provided an assessment of repeatability of the Fastrak system.

The Fastrak system was successful in acquiring data in 3 D. The transmitter and the sensor were easy to attach and were of no discomfort to the subjects. As expected the maximum movement was noted in the flexion-extension plane. The total arc of movement in the flexion-extension plane was 127.1 degrees and 69.7 degrees in the radio-ulnar plane. There was no statistically signifi-cant difference between the movements in the left and the right wrists, even when the effect of dominance was considered. The lift and move task showed that most subjects utilised three-fourths of the total possible radio-ulnar movement, but only one-thirds of the total flexion and extension. The writing simulation revealed a substantial variability between subjects. The Fastrak system revealed variation up to 3 degrees in the means of range of movements, while measuring wrist movements.

The current study showed that the Fastrak system is a user-friendly and repeatable device, which could be used in everyday clinical use. It has the potential to be used for evaluation of the diseased wrist and the results of therapeutic interventions, operative or otherwise.


A G AJ Hamer I Stockley R Eastell JM Wilkinson

Introduction: The concept that aseptic loosening is a function of polyethylene wear has led to the use of cross-linked polyethylene in total hip arthroplasty (THA). We studied the relationship between polyethylene wear rate and aseptic loosening in order to model the potential effects of wear-reducing strategies on the failure rate for each prosthetic component.

Methods: 350 subjects who had previously undergone Charnley THA were divided into 3 groups: Controls (n=273); those with loosening of only the femoral stem (n=43); and those with only cup loosening (n=34). Poly-ethylene wear was measured using a validated method (EBRA). The relationship between wear rate and loosening was examined using logistic regression analysis, and estimates of the effect of wear rate modulation made using odds-ratios.

Results: The median annual wear rate in the controls (0.07mm) was lower than both stem looseners (0.09mm, p=0.002) and cup looseners (0.18mm, p< 0.001). The odds of cup loosening increased 4.7 times per standard deviation (SD) increase in wear rate above the reference (control) population (p< 0.001). The odds of stem loosening increased 1.7 times per SD, but was not independent of other risk factors (p> 0.05). The potential reduction in risk of loosening was calculated using the following formula: (OR^SD2)/(OR^SD1), where 1 and 2 are the new and old mean z-score wear rates. Thus, for a 25% or 50% reduction in wear rate, the incidence of cup loosening may reduce by 71% and 293%, respectively. The rate of stem loosening may, at best, reduce by 7% and 17%, respectively.

Discussion: Wear reduction strategies, such as cross-linked polyethylene, have the potential for a major impact on the incidence of cemented cup, but not stem, loosening.


SC Scholes A Unsworth

Introduction: In an attempt to prolong the lives of implantable devices, several ‘new’ materials are undergoing examination to determine their suitability as joint couplings. As part of a series of tests, polyetherether-ketone (PEEK) against cobalt chrome molybdenum (CoCrMo) and carbon fibre reinforced-PEEK against CoCrMo were tested on a multidirectional pin-on-plate machine.

Materials and methods: The two four station pin-on-plate machines used in this study applied both reciprocation and rotational motion. Each material combination was tested individually on separate machines. Four samples of PEEK pins against CoCrMo plates were tested and eight samples (two tests) of CFR-PEEK pins against CoCrMo plates were tested. The pins were supplied by Invibio Ltd. A 40 N load was provided to each station. The lubricant used was 24.5 % bovine serum (protein content: 15 g/l) and this was heated to 37 degrees C. The wear was assessed gravimetrically and the tests each completed 2 million cycles.

Results: On average, the pin and plate wear factors were 7.37 and 0.010 x 10 -6 mm3/Nm for PEEK-CoCrMo and 0.144 and 0.011 x 10 -6 mm3/Nm for the CFR-PEEK against CoCrMo specimens respectively. These results show the wear of the components corrected relative to the control specimens that therefore took into account the weight gain due to lubricant absorption.

Discussion: The CFR-PEEK pins gave considerably lower wear against CoCrMo than the PEEK pins. It is interesting to note that the total wear factor provided by high carbon CoCrMo pins articulating against high carbon CoCrMo plates (which is known as a low wearing material combination in hip implants) was found to be 0.84 x 10 -6 mm3/Nm (1) which is actually higher than that found in these studies for CFR-PEEK against CoCrMo tested under the same conditions.

Conclusions: CFR-PEEK articulating against CoCrMo provided much lower wear than the PEEK-CoCrMo samples. This material combination also gave lower wear than metal-on-metal samples. This, therefore, indicates that this material combination may perform well in joint applications.


P Pankaj FA Beeson C Perrone ATM Phillips AHRW Simpson

Micro level finite element models of bone have been extensively used in the literature to examine its mechanical behaviour and response to loads. Techniques used previously to create these models involved CT attenuations or images (e.g. micro-CT, MRI) of real bone samples. The computational models created using these methods could only represent the samples used in their construction and any possible variations due to factors such as anatomical site, sex, age or degree of osteopo-rosity cannot be included without additional sample collection and processing. This study considers the creation of virtual finite element models of trabecular bone, i.e. models that look like and mechanically behave like real trabecular bone, but are generated computationally.

The trabecular bone is anisotropic both in terms of its micro-architecture and its mechanical properties. Considerable research shows that the key determinants of the mechanical properties of bone are related to its micro-architecture. Previous studies have correlated the apparent level mechanical properties with bone mineral density (BMD), which has also been the principal means of diagnosis of osteoporosis. However, BMD alone is not sufficient to describe bone micro-architecture or its mechanical behaviour. This study uses a novel approach that employs BMD in conjunction with micro-architectural indices such as trabecular thickness, trabecular spacing and degree of anisotropy, to generate virtual micro-architectural finite element models. The approach permits generation of several models, with suitable porous structure, for the same or different levels of osteoporosity. A series of compression and shear tests are conducted, numerically, to evaluate the apparent level orthotropic elastic properties. These tests show that models generated using identical micro-architectural parameters have similar apparent level properties, thus validating this initial bone modelling algorithm. Numerical tests also clearly illustrate that poor trabecular connectivity leads to inferior mechanical behaviour even in cases where the BMD values are relatively high. The generated virtual models have a range of applications such as understanding the fracture behaviour of osteoporotic bone and examining the interaction between bone and implants.


S Fang SP Ahir GW Blunn AE Goodship

We previously demonstrated that cartilaginous tissue was induced on a reamed acetabular articulation in an ovine hemiarthroplasty model with three different femoral head sizes. At maximum loading during stance phase, the acetabular peak stresses immediately after reaming could reach approximately 80 MPa under direct implant-bone contact with in-vitro measurements.

We aimed to establish finite element (FE) models of the ovine hip hemiarthroplasty which examine stress distribution on the reamed acetabula by three head sizes. We hypothesized that the stress distribution did not differ between different sizes when the joint is congruent and that the peak stresses in the acetabulum immediately after reaming occurred in the dorsal acetabulum.

Three two-dimensional FE models of ovine hip hemi-arthroplasty were built; each comprised a head component, 25, 28, and 32 mm in diameter, and an acetabular component. The acetabular geometry was acquired from an ovine acetabular histological section. The head was moved to partly intersect with the acetabulum representing the reaming procedure and a congruent contact was confirmed. Cortical bone and cancellous bone were modelled as linear elastic, with moduli of 20 and 1.2 GPa, respectively. Variable moduli were also assessed. The finest mesh for each model consisted of over 100,000 four-node quadrilateral elements. Loading conditions were chosen to represent peak hip joint force developed during the stance phase. Stress distribution in the acetabular area in contact with the head was plotted against the articulating arc length.

The results confirmed that the stress distribution between different prosthetic head sizes in a reamed hemiarthroplasty model did not change when the joint was congruent. The peak compressive stresses occurred in the dorsal acetabulum with the 32 mm model being the highest at approximately 69 MPa, the 28 mm model at 63 MPa, and the 25 mm model at 54 MPa. An increase in the cancellous modulus and a decrease in the cortical modulus increased the peak stresses in the dorsal acetabulum.

This presents an indicative study into the effect of prosthetic femoral head sizes on the stress distribution in the acetabulum. The idealized 2-D models showed reasonable agreement when compared quantitatively with the in vitro study.


I Udofia F Liu Z Jin P Roberts P Grigoris

Metal-on-metal hip resurfacing arthroplasty is a conservative procedure that is becoming an increasingly popular option for young arthritic patients most likely to undergo a secondary procedure in their lifetime. The stability of the acetabular component is of particular concern in these patients who show an increased risk of failure of the cemented acetabular cups in conventional total hip replacements. The purpose of this study was to examine the initial stability of a cementless interference press-fit acetabular cup used in hip resurfacing arthroplasty and implanted into ‘normal’ versus poor quality bone. Also examined was the effect of the press-fit procedure on the contact mechanics at the cup-bone interface and between the cup and femoral head.

A finite element (FE) model of the DUROM resurfacing (Zimmer GmbH) was created and implanted anatomically into the hip joint, which was loaded physiologically through muscle and subtrochanteric forces.

The FE models included: a line-to-line, 1mm and 2mm interference press-fit cup. Also considered were two FE models based on the 1mm press-fit cups, in which the material properties of the cancellous and cortical bone tissues were reduced by 2 and 4 times, to represent a reduction in bone quality as seen with age or disease.

Increasing the cup-bone interference resulted in a sig-nificant reduction in implant micromotion. All the pressfit models showed predicted cup-bone micromotion below 50 micrometers. This would ensure adequate initial stability and encourage secondary fixation through bone in-growth. The predicted acetabular stresses were found to increase with the amount of press-fit, however, there was no suggestion of a fracture. These stresses would further contribute to securing the cup.

Reducing the bone quality showed an increase in the predicted micromotion and increased bone strain. Micromotion was below 50 micrometers, but the predicted compressive bone stresses, necessary for additional implant fixation, was reduced. This implied that poor quality bone would provide unsuitable support medium for the implant. The bearing surface contact mechanics were little affected by the amount of pressfitting.


M Ganapathi S Jones P Roberts

Purpose: The aims of our study were: (i) to measure the total metal content in cell saver blood recovered during revision hip arthroplasty, (ii) to evaluate the efficacy of centrifuging and washing the recovered blood in reducing the metal content, (iii) to investigate whether transfusion of the salvaged blood resulted in a significant increase in the metal ion levels in the patients’ blood in the immediate post-operative period.

Materials and methods: We analysed the levels of metallic debris and metal ions in cell saver blood in nine patients undergoing revision hip replacement. Using inductively coupled plasma mass spectrometry (ICP-MS), the levels were measured for titanium, aluminium, vanadium, chromium, cobalt, nickel and molybdenum. The metal ion levels were analysed using a dilution technique and the total metal content levels (particulate debris and ions) were analysed with a digestion technique.

Results: Significantly higher levels of metal ions and metal debris were found in the pre-processed blood compared with the processed blood (after centrifuging and washing). The ion levels in the processed blood were not high enough to cause a significant increase in the patients’ immediate post-operative blood ion levels when compared with pre-operative levels.

Conclusion: There are markedly elevated levels of metal ions and particulate metal debris in the blood salvaged during revision total hip arthroplasty. The processing of the recovered blood in a commercial ‘cell saver’ sig-nificantly reduces the total metal load that is re-infused. Re-infusion of salvaged blood does not result in elevated metal ion levels in the immediate post-operative period.


J Tong KY Wong C Lupton

The long-term stability of total hip replacements (THRs) critically depends on the lasting integrity of the bond between the implant and the bone. Late failure in the absence of infection is known as ‘aseptic loosening’, a process characterised by the formation and progressive thickening of a continuous layer of fibrous tissue at the interface between the prosthesis and the bone. Aseptic loosening has been identified as the most common cause for long-term instability leading to the failure of ace-tabular cups. There is clearly a need to study the failure mechanisms in the acetabular fixation if the long-term stability of THR is to be significantly improved. The bonding strength in the presence of defects is measured using interfacial fracture toughness, and this information is not available currently.

In this work, interfacial fracture toughness of synthetic and bovine bone-cement interface has been studied using sandwiched Brazilian disk specimens. Experiments were carried out using a common bone cement, CMW, and polyurethane foam under selected loading angles from 0 to 25 degrees to achieve full loading conditions from tensile (mode I) to shear (mode II). Finite element analyses were carried out to obtain the solutions for strain energy release rate at a given phase angle (ratio of shear and tensile stress) associated with the experimental models. The effects of crack length on the measured interfacial fracture toughness were examined. Microscopic studies were also carried out to obtain the morphology of the fractured interfaces at selected loading angles.

The results show that both polyurethane foam and bovine cancellous bone seem to produce a similar type of interfacial failure of bone-cement interface, with cement pedicles being ‘pull-out’ of the pores of the foam/ bone. Damage sustained by the cement pedicles seems to increase progressively as the increase of shear loading component. The measured values of fracture toughness are a function of crack length and phase angle, and are comparable with those published in the literature on cortical bone and cement interface.

The implication of these results on the assessment of fixation in acetabular replacements is discussed, particularly in the light of results from bovine cancellous bone-cement interface.


M Ganapathi JH Kuiper SG Griffin ES Saweeres NM Graham

Purpose: To investigate whether cement mantle thickness influence early migration of the stem after impaction grafting

Methods: Twelve artificial femora were prepared to mimic cavitary defects. After compacting morselized bone into the cavities, Exeter stems were cemented in place. By using all combinations of three sizes tamps and stems (0, 1 and 2), we created cement mantles of 0, 1, 2, 3 and 4 mm thickness. Bones with stems were placed in a testing machine and loaded cyclically to 2,500 N while measuring stem migration. Statistical analysis was by regression analysis. Outcomes were stem subsidence and retroversion, predictors were mantle thickness, tamp size and stem size.

Results: Average stem subsidence after 2500 cycles when using size 1 tamp and stem (2 mm mantle) was 0.94 mm. Cement mantle thickness significantly influ-enced stem subsidence (r=0.68, p=0.015). For a 0 mm mantle, subsidence was 0.59 mm and for a 4 mm mantle it was 2.54 mm. Cement mantle thickness also signifi-cantly influenced stem retroversion (r=0.62, p=0.031). Cement mantle thickness was a better predictor than tamp or stem size.

Discussion: Concern exists that inadequate cement mantles may affect stability of impaction-grafted stems. In our study, larger difference between tamps and stems gave substantially more subsidence and rotation, whereas a smaller difference reduced them. Concerns over thin mantles may have been premature.


AP Kadakia S Green PF Partington

Introduction: There has been a renewed interest in metal-on-metal bearing for total hip replacement with the benefit of a larger head size and decreased incidence of dislocation. In the revision hip scenario cementation of a polyethylene liner, for a previously compromised liner fixation mechanism into a preexisting well-fixed shell or a cage, has become an accepted method to decrease the morbidity of the procedure. Perhaps Bir-mingham cementless cups could be used as cemented devices in primary and revision hip surgery where a cementless cup is not possible.

Aim: To study the pull-out strength of cemented Bir-mingham sockets in an experimental model.

Materials and Methods: Eight Birmingham cups were cemented into wooden blocks after they were reamed to the appropriate size allowing for a 3mm cement mantle, multiple holes drilled into the reamed sockets and cement vacuum-mixed. Cable was then threaded through the holes on the rim of the cup and the wooden block was then mounted on a metal plate and secured. Linear tension was then gradually applied on the cup through the cable.

Results: The pull-out strength of the cemented Birming-ham cups was higher than the failure of the cable. The tensile load to failure for the cables ranged from 3642.6 N to 4960 N with an average load of 4286.9 N.

Conclusion: The average tensile load of 4286.9 is very high compared to previous studies with cemented poly-ethylene and metal liners. This finding is very promising and might support clinical application in complex primary and revision total hip replacement.


P Pankaj ATM. Phillips CR Howie AJ McLean AHRW Simpson

Morsellised cortico-cancellous bone (MCB) is used extensively in impaction grafting procedures, such as the filling of cavitory defects on the femoral and acetabular sides during hip arthroplasty. Several experimental studies have attempted to describe the mechanical behaviour of MCB in compression and shear, and it has been found that it’s properties can be improved by washing and rigorous impaction at the time of surgery. However their focus has not been on the development of constitutive models that can be used in computational simulation.

The results of serial confined compaction tests are presented and used to develop constitutive models describing the non-linear elasto-plastic behaviour of MCB, as well as its time dependent visco-elastic behaviour. It is found that the elastic modulus, E of MCB increases linearly with applied pressure, p, with E achieving a value of around 30 MPa at a pressure of around 1 MPa. The plastic behaviour of MCB can be described using a Drucker Prager Cap yield criterion, capable of describing yielding of the graft in shear and compression. The time dependent visco-elastic behaviour of MCB can be accurately modelled using a spring and dashpot model that can be numerically expressed using a fourth order Prony series. The role of impaction in reducing subsequent plastic deformation was also investigated. The developed relationships allow the constitutive modelling of MCB in finite element simulations, for example of the acetabular construct following impaction grafting. The relationships also act as a gold standard against which to compare synthetic graft and graft extender materials.


AR Tolat RS Reddy I Persad J Compson A Amis

Three methods to reattach avulsed finger flexor tendons to the distal phalanx were compared: a 1.8 mm metal barbed suture anchor, twin 1.3 mm PLA (polylactic acid)absorbable anchors, or a pull-out suture over a button. The suture-anchor interface was tested by pulling the suture at 0, 45, and 90 degrees to the anchor’s axis. The anchors were tested similarly in plastic foam bone substitute. Repairs of transected tendons in cadaveric fingers were loaded cyclically, then to failure. The suture failed prematurely if pulled across the axis of the anchor. Conversely, fixation in bone substitute was stronger when pulling at an angle from the axis. Cyclic loads caused significantly more gap formation in-vitro with twin 1.3 mm absorbable anchors than the other methods; this method was significantly weaker. The 1.8 mm anchor gave similar performance to the pull-out suture over button technique, while the twin 1.3 mm absorbable anchors were weaker and vulnerable to gap formation even with passive motion alone.


P Heaton-Ade N Zant J Tong

Retrieval studies based on revision operations at King Edwards VII Hospital reveal that, although micro-cracks develop in the cement mantle, it is the debonding between cement and bone that often defines the final failure of cemented acetabular replacements. This was illustrated at the revision surgeries by the easy removal of the acetabular cups with cement mostly attached to the cup. It is felt that a fundamental understanding of the mechanisms that initiate and propagate the interfacial failure at the bone-cement interface is the key towards solving the problem.

In this work, in-vitro fatigue tests were carried out on cemented acetabular replacements using third-generation of composite pelvic bones. Standard Charnley cups were implanted using common bone cement, CMW, following the standard surgical procedures. The implanted hemi-pelvic bone model was then constrained at the sacro-iliac and pubic joints to represent the anatomic constraint conditions. Cyclic loads representing the maximum range of the hip contact force during normal walking were used and the direction of the maximum hip contact force was achieved by using angled plates. In addition to standard cup position, open cup and retroverted cup positions were also examined to assess the significance of cup orientation under fatigue loading conditions.

Damage development in the reconstruction was monitored using CT scanning at regular intervals. Permanent records were collected and the sample was eventually sectioned and polished for microscopic studies. Results show excellent correlations between the results from the CT images and the microscopic studies, indicating progressive bone-cement interfacial failure in the posterior-superior quadrant.

The significance of the work in the studies of ‘aseptic loosening’ will be discussed.


JCJ Webb S Gheduzzi RF Spencer AW Miles ID Learmonth

The visco-elastic behaviour of cement, is a key feature of cement-implant performance in total hip arthroplasty.

The aim of this study was to describe the creep behaviour of the leading plain bone cements under standardised physiological in-vitro conditions.

Methods: Cements were mixed under vacuum conditions as per manufacturers instructions. Moulds were used to to produce beams of standard dimensions. These were stored in saline at 37oC for 21 days to ensure thorough polymerisation. Under the same conditions, the beams were tested for 72 hours in a 12-station quasi-static creep rig, using a four-point bending configuration. The rig applied a constant stress of 8MPa to each beam and the deflection was recorded at 8-minute intervals by a data-logging device. The porosity was measured in the mid-cross section of each beam sample using a digital image technique.

The cements tested were Palacos R, CMW1 and Smartset GHV and Surgical Simplex P.

All data were analysed using ANOVA with Bonfer-roni post-hoc test (SPSS).

Results: Palacos R exhibited the highest mean deflection at 72 hours (0.86+/- 0.21mm) followed by Surgical Simplex P (0.85 +/- 0.18mm), CMW1 (0.72 +/- 0.09mm) and Smartset GHV (0.60 +/- 0.16mm). The difference between the two DePuy cements and Palacos R (p=0.03) and Surgical Simplex P (p=0.04) were statistically sig-nificant. None of the beams failed during the test. The creep behaviour correlated with the cross-sectional porosity measurements.

Conclusions: This study has shown that there are sig-nificant differences in the creep bahaviour of the leading medium and high viscosity bone cements. In particular Palacos R and Surgical Simplex P demonstrate ‘High’ creep and the DePuy cements ‘Low’ creep. Creep appears sensitive to subtle changes in the composition of the material. This may be reflected in the clinical behaviour of different bone cements and stresses the importance of the time-dependent properties of PMMA.


V Kumar P Kanabar PJ Owen N Rushton

Background: To analyse the effectiveness and complications of Less Invasive Stabilisation System (LISS plate) in the management of peri-prosthetic femoral fractures.

Materials and methods: We present a study of 18 peri-prosthetic femoral fractures around hip arthroplasty (16 females and 2 male patients) treated with LISS plate between September 2001 to February 2005. The average age of the patients was 81.6 years. Twelve patients had significant co-morbidities pre-operatively. All the fractures were classified according to the Vancouver classification for Peri-prosthetic fracture of femur. Ten were classified as type B1, two as type B2 and six as type C. Eleven fractures were around total hip replacement and seven were around hemi-arthroplasty (four cemented and 3 uncemented). Partial weight bearing started early post-operatively. Full weight bearing varied between 5-6 weeks depending on clinical and radiological status. The patients were followed up untill fracture union.

Results: Three patients died during the follow-up period owing to unrelated causes. The average follow up period was 11.7 months. All the remaining fifteen patients had satisfactory fracture union although one patient required further LISS plate following a fall 17 days postoperatively and another one patient developed low grade deep infection with a chronic sinus. It was noted that in one patient, plate had lifted off the bone at the proximal end with no loss of reduction of the fracture. Three patients were noted to have mild to moderate discomfort around the prominent implant. No implant breakage noted.

Conclusions: Even though LISS plate was originally designed for distal femoral fracture treatment, it appears to be very promising device in the treatment of peri-prosthetic femoral fractures (Type B1, Type C and medically unfit patients with Type B2 for stem- revision) with osteoporotic bone in elderly patients. Early mobilization is a key feature. This system involves minimally invasive approach, stable construct without need for primary bone grafting.


VG Bulgakov NS Gavryushenko AN Shal’nev

The intensification of free radical processes at total joint replacements is well known. Wear particle-induced inflammatory reaction and metal corrosion is associated with generation of the oxygen radicals. At the normal functioning of joint implants there is a natural deterioration and constant updating of their surfaces. In these conditions probably also formation of free radicals during tribochemical reactions.

The radical-generating ability of the wear particles of orthopaedic alloys, alumina ceramics and antioxidant properties of various cured cements and UHMWPE were studied using the model reaction of cumene oxidation. Artificial wear particles of different alloys and ceramics were obtained using dry friction of a ball against a disk made of appropriate materials. Cement powders were obtained by grinding cement samples in a ceramic mortar.

Wear particles of orthopaedic alloys were found to initiate cumene oxidation whereas ceramic particles were inert. It was revealed that cobalt-chromium-molybdenum particles were much more active than titanium-aluminum-vanadium and stainless steel particles. Different amounts of antioxidants (from 2.3 to 12 millimole/kg) were detected in cured cements which considerably exceeded their amounts in the initial liquid cement components. The content of antioxidants in cured ÑÌW-1 cement was 3-5 times more than that in Palacos P and Sulcem1 cements. The amount of anti-oxidants was considerably lower in UHMWPE than in the mentioned cements. The reactivity of combinations of different particles is determined by relative particles’ contributions, and such mixtures are able to demonstrate either antioxidative (alloy-cement mixture) or prooxidative (alloy-UHMWPE mixture) properties. In particular, cement particles suppressed cumene oxidation caused by cobalt alloy particles. Inhibition duration depends on the ratio between alloy and cement particles and on the content of antioxidants in cements. Polyeth-ylene particles were not able to inhibit cumene chain oxidation caused by cobalt alloy particles.

Investigation of prooxidant and antioxidant behavior of the wear particles of orthopaedic materials provides better insight into their action on surrounding tissues and implant components. In particular, it is necessary to develop methods of preclinical testing that can simulate and estimate the action of radical intermediates generated in the course of tribochemical reactions on implant components.


STS Salisbury CP Buckley AB Zavatsky

More than 100,000 anterior cruciate ligament reconstructions are performed annually in the USA. The hamstrings and the patellar tendons are the most frequently used graft tissues. Up to ten percent of these grafts are deemed to have failed, generating considerable discussion in the literature regarding the ideal graft choice. A three-dimensional computational model, taking into account both material and geometrical non-linearities, would be useful in predicting the performance of different graft tissues and fixations. Unfortunately, the mechanical characteristics and parameters needed for such a model are complex and largely unknown. The aim of this study is to develop a method for measuring the geometrical properties needed as input for a three-dimensional tendon model.

A laser-based, non-contact technique is used to generate a series of cross-sectional profiles along the length of the tendon. Unlike previously proposed methods, it is able to detect concavities and can be constructed using equipment commonly found in an engineering laboratory. A laser line generator (Stocker-Yale Lasiris SNF, Quebec, Canada) projects a horizontal line onto the sample. Images of the line are acquired with a digital video camera (Basler A631fc, Germany) as the tendon is rotated. These images are reassembled into 2-D slices using MatLab software. Multiple cross-sections can be combined to create three dimensional geometries.

The new method was validated on objects of known shape (circular and hexagonal cylinders). The cross-sectional area measurement was found to be accurate to within 2.5%. The method was repeatable to within 1.7%. Six bovine flexor tendons have been analysed; concavities were evident in four of these. This method could be adapted to determine the surface geometries of other long and slender objects.


CY Ng F Borocin A Muir H Simpson

Thermonecrosis either results in bone loss which may weaken the purchase of surgically-inserted screws leading to loosening or the dead bone may remain in situ and become infected resulting in a ring sequestrum. The aim of this project was to measure the heat generated during drilling of bone. By using a novel realtime thermal camera the thermal events could be visualised topographically.

An experimental setup comprising a force table, an infrared camera, a power drill and a new surgical 2.5mm drill bit was constructed. This enabled measurements of the force applied and temperature changes in sheep cortical bone during a drilling operation. The temperature was observed throughout the drilling period and for further 15s after the drill bit was withdrawn. Images were grabbed using a LAND FTI Mv thermal camera which was driven by LIPS Mini software. Calibration was made in the range 20-200 degrees C, the upper value being provided by a high wattage resistor. Data was processed using routines written in MATLAB.

It was found that 12s were required to drill through a single cortex. Within one second of drilling, the maximum recorded temperature in the vicinity of the drill increased from the baseline of 20 to 170 degrees C. It remained above this temperature for 25s. Immediately after the drill bit was withdrawn, a region of approximately 15mm of diameter of cortical surface had a sustained temperature above 50 degrees C. After 15s of cooling, this diameter had only reduced to 10mm. By modelling the cooling curve, the maximum temperature at the drill tip was extrapolated to be between 500-600 degrees C.

Thermography has proven to be useful in the study of the thermal characteristics of bone during drilling. The process of drilling generates significant increase in temperature in the vicinity of the drill. This temperature elevation has been found to be sustained for a significant period of time.


AM Byrne C Ridge SR Kearns SK O’Rourke W Quinlan

Background: Nonagenarian patients with hip fractures present many challenges to the clinician, both in terms of their advanced age and medical co-morbidities with potential orthopaedic complications. Our aims were to assess outcome of hip fractures in a nonagenarian population with respect to pre-operative predictors of outcome, immediate and long-term morbidity, and survival rates.

Methods: All nonagenarian patients with a hip fracture admitted to our unit between January 2000 and Decem-ber 2003 were considered. Eighty-one patients were included, the majority being female (M: F 14: 67). Ages ranged from 90 to 98 years for female patients (mean 92.5 years, SD 2.2) compared to 90 to 95 years for male patients (mean 92.7 years, SD 2).

Results: Delay to surgery was 1.25 days and the median ASA grade was III. The method of anaesthesia used was spinal in 78% and general in 22%. The majority of patients had intertrochanteric fractures and methods of fixation involved internal fixation in 63% and hemiarthroplasty in the remaining 36% of the group deemed fit for surgery. The rate of complications during inpatient stay was 19% and there were eight in-patient post-operative mortalities due to medical complications. Mean survival post hip fracture in our patient group was 474.7 days (median 372.5 days). Within forty days of surgery 25% of patients died, including our inpatient mortality of 10%. However, 50% of the patients were still alive 126 days post-operatively.

Conclusion: Hip fractures must be given special attention in the nonagenarian population because of their advanced age and medical co-morbidities. Careful pre-operative assessment and medical maximisation combined with prompt surgical intervention yielded a good outcome and return to pre-injury status for most patients. Lower ASA grades, surgery within 48 hours, and increased pre-operative haemoglobin levels were all associated with favourable outcomes. Medical complications were the major cause of morbidity and mortality with a low rate of orthopaedic complications. The majority of patients were able to return to their previous residence and continued to be mobile with various levels of assistance.


AN Ku AN Mitroshin SD Litvinov

Restoration of the bone defects on the background of the purulent osteomyelitis process is one of most pressing problems in orthopedics. In the last few years the medical procedure was improved thanks to use of semi-synthetic or syntetic implantation biodegradable composite materials.

The object of the investigation is to study possibilities of use of fast-biodegradable implant LitAr (Russia) for filling infected bone defects in course of complex treating various osteomyelites forms.

The composite material LitAr (in plates) is a mixture of components: xenocollagen and hydroxoapatite. Material is intended for stimulating osteogenesis. In event of infection materials LitAr in 7-10 days is lysed by the wound and microbe ferments and cannot support purulent process. Composite material was introduced into osteomyelitis defect intraoperative through an open wound by introducing a dry substance through fistu-las as well as in form of a suspension in 0.9%-sodium chloride solution. For 13.6% of patients postoperative time period was complicated by suppuration of operative wound. It was stated in course of use of material LitAr that in spite of secondary wound suppuration active osteogenesis rate was little different from similar process for patients with wound healing by first intention. It made it possible to use material more active for patients of advanced years because it was impossible to use a radical sanitation of purulent bone cavity for these patients. Material LitAr was used for 13 patients with osteomyelitis cavities. In form of a suspension (injection-ally or through a fistular duct) in 0.9% NaCl solution material was introduced through fistulas for 8 patients with an affected shin bone. Roentgenological signs of consolidation emerged by 35-40 days. A complete ossi-fication set in by 95-120 days. Immobilization was performed by use of plaster. In far-off time periods (about 2 years) no pathologic fractures were noted. 2 patients had a relapse of fistulas formation (15.4%).

The use of implant LitAr for filling infected bone defects for stimulating osteogenesis and for restoring bone continuity in a complex treatment of various forms of osteomyelitis can be considered as an effective one including for patients because it was impossible to perform a radical sequestrectomy for these patients.


AD Gorva NJ Bishop AC Cole

Introduction: Lumbar spine morphology is well described in healthy children but has not been described in children with Osteogenesis Imperfecta (OI).

Aims: To look at lumbar bony morphometry in OI children and to consider the importance of these factors in spinal surgery in these children

Methods: 21 lumbar vertebrae (from L3-5) of 7 OI (6 OI type 3 and 1 OI type 4) children with scoliosis were analysed using Reformatted Computer Tomographic scans. The following measurements obtained: Spinal canal diameters, Transverse pedicle width, Total pedicle length, Pedicle root length, Transverse pedicle angle and Sagittal pedicle angle. Results are compared with previously published data of normal age-matched lumbar spine measurements

Results: The mean age was 12 years (range 7-18 years). 6 females and 1 male. All had spondylolisthesis at L5-S1. Results were analysed by Wilcoxon Signed Rank test (nonparametric test). The transverse pedicle width was significantly narrower at all 3 levels (p< 0.01). Transverse pedicle angle was significantly less angled at all 3 levels (L3 p=0.04, L4 & L5 p< 0.01) whilst the sagittal pedicle angle was significantly more angled at all 3 levels (p< 0.01). Spinal canal diameter (AP) was significantly increased at all 3 levels (L3 & L5 p< 0.01, L4 p=0.02). And no significant differences in spinal canal transverse diameter and total pedicle length. Pedicle root length Significantly longer at all 3 levels (L3 & L4 p< 0.05, L5 p< 0.01). All children had grade-I spondylolisthesis at L5/S1.

Conclusions: A longer pedicle root with a narrower transverse diameter (and thinner cortices) and a reduced transverse angle is essential knowledge when passing pedicle screws in the lumbar spine in children with OI. This is a difficult technique and its safety requires further evaluation.


RE Weaver J Dudhia ERC Draper RKW Smith AE Goodship

Objective: To challenge the validity of using biomarker concentrations in synovial fluid for the assessment of joint pathology.

Hypothesis: Synovial fluid biomarker concentrations are influenced by both cartilage and synovial fluid volumes.

Methods: Synovial fluid volumes were determined from the equine metacarpophalangeal (MCP), proximal inter-phalangeal (PIP) and distal interphalangeal (DIP) joints, which have different disease prevalences.

Chondrocyte density was calculated from a defined site in each joint.

Cartilage volume was measured by novel application of Peripheral Quantitative Computed Tomography (pQCT).

Cartilage oligomeric matrix protein (COMP), glycos-aminoglycans (GAG) and total protein (TP) concentrations were measured and then adjusted for cartilage and synovial fluid volume and compared between joints.

Results: Mean synovial fluid volume was significantly greater in the MCP than the distal joints (p< 0.0001) (3.2 ±0.5ml, 0.5 ±0.1ml and 0.6 ±0.1ml respectively). In contrast, the DIP had the greatest cartilage volume compared to the proximal joints (5360 ±667mm3 2640mm3, 1940 ±331mm3 respectively). There was no significant difference in the cartilage cellularity between all joints.

The DIP had higher TP, COMP and GAG concentrations, however, when values were expressed per unit cartilage volume the opposite was found, with the MCP then exhibiting significantly higher concentrations.

Conclusions: These data show the joint with the highest prevalence to osteoarthritis has the lowest biomarker synovial fluid concentrations but the highest biomarker levels per unit cartilage, suggesting a higher release. These results indicate that meaningful interpretation of biomarkers in synovial fluid require consideration of both fluid and cartilage volume.


A Awad JG Andrew C Williams C Hutchinson

Older fracture patients frequently ask whether their osteoporosis will affect fracture healing. There is only limited previous data about this. We investigated recovery after distal radial fracture, and compared it with BMD of the other distal radius and the lumbar spine (measured using quantitative CT).

All 28 patients had sustained a dorsally displaced distal radial fracture which was deemed to require treatment by intrafocal wire fixation. All patients had acceptable correction of dorsal and radial angle at final x ray (3 months). Wrist function was measured using the Patient Rated Wrist Evaluation (PRWE – a validated outcome measure for use after distal radial fractures), grip strength,and range of motion. All measurements were made at 6, 12 and 26 weeks. BMD was measured in the opposite wrist and the lumbar spine using QCT at 6 weeks after fracture.

There was no correlation between recovery of grip strength (% of contralateral grip strength) at 6,12,or 26 weeks with BMD at either site. Similarly, there was no correlation between BMD and either absolute PRWE scores at any time point or improvement in PRWE between time points. The strongest predictor of recovery of grip appeared to be the proportion of grip recovered at 6 weeks (correlation between% grip recovered at 6 weeks and 3 months r = 0.85; at 6 weeks and 6 months r= 0.56; both p < 0.001). This was not affected by age or variations in measured final dorsal or radial angles or length within this group. It was not affected by degree of preoperative fracture displacement.

These data suggest that recovery of function after distal radial fractures is not influenced by osteoporosis. The data about the importance of initial recovery of grip suggest that factors other than bone position and bone healing may affect rate of functional recovery after distal radial fracture.


SG Haidar S Joshy RM Charity S Ghosh AB Tillu SC Deshmukh

Purpose: Management of the unstable or comminuted displaced fractures of the distal radius is difficult. We report our experience treating these fractures with AO volar plate fixation. An attempt to introduce a new radiological classification for the accuracy of surgical reduction is made. The classification includes 10 criteria and 100 points.

Methods: 124 patients had volar plate fixation performed between June 2000 and May 2003 using AO volar plate. We reviewed clinically and radiologically 101 patients; 60 were type C and 41 were type A (after failed conservative treatment). The average follow up is 37 months (24 – 57). The average age is 46 years (19 – 81). Postoperative regimen consisted of immediate physiotherapy and a wrist splint for three weeks. Cooney’s modification of Green and O’Brien and Sarmiento’s modification of Gartland and Werley were used for clinical assessment. Lidstorm and Frykman used for radiological assessment.

Results: At final follow up the means of distal radius parameters were: volar tilt of 9 degrees, radial inclination of 22 degrees, radial height is 11mm and palmer cortical angle of 32 degrees. The mean dorsiflexion was 61 degrees, palmer flexion was 59 degrees, pronation was 80 degrees and supination was 76 degrees. Grip strength was 86 percent of the opposite side. The average DASH score was 13.6. There was 14 poor results, 6 of them had significant loss the initial reduction. There was significant correlation between our classification and the clinical outcome.

Conclusion: AO volar plate fixation of unstable distal radius fractures provides strong fixation that maintains reduction and allows early mobilisation.


I GillI K Gill N Jayasekera AJ Miller

The Pipino prosthesis was introduced as an alternative to hip resurfacing because of its bone preserving capability. Preserving the femoral neck to a greater extent saves valuable bonestock for possible revision procedures. The stem (proximal 2/3) and acetabular cup are hydroxyapatite coated. Bearings were all either ceramic or metal on polyethylene. All procedures were performed or directly supervised by the senior author.

Patients in the cohort were assessed pre-operatively, in the short term and the medium term using the Harris Hip Score(HHS). Hip radiographs were performed at medium term follow-up to assess for radiological signs of aseptic loosening.

The study is based on a cohort of 70 patients, 34 male and 36 female with mean age of 52 (range 13-71). Followed up over a mean period of 43 months (range 17-60). 70 patients were contacted and 64 patients were reviewed. Four patients were lost to follow-up. Indications for surgery were Osteoarthritis (56); Rheumatoid arthritis (8); AVN (3); SUFE (2); Perthes (2); DDH (1); Psoriatic Arthropathy (1).

The cohort’s preoperative HHS showed a mean 50.1 (range 25-88). This increased to a mean of 95.9 (range 55-100) in the short term review period, during the medium term review the mean 93.6 (range 63-100). With 82% of patients in the excellent group and 88% good to excellent group.

At the final review there was one case of aseptic loosening (Cup) which required revision surgery. There were 2 dislocations and one intraoperative lateral femoral wall fracture and no cases of superficial or deep infection.

In conclusion we believe that the Pipino collum femo-ris preserving total hip arthroplasty has excellent short and medium term results.


JA Gallagher BH Van Duren H Pandit D Beard HS Gill CAF Dodd DW Murray

Background: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range, increased medial compartment pain and a higher dislocation rate than seen with its medial counterpart due to the inadequacy of a flat tibial tray replacing the domed anatomy of the lateral tibia. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to overcome these problems. This current study was designed to establish whether this modi-fied ‘domed’ implant has maintained the established normal kinematic profile of the Oxford UKR.

Methods: The study population consisted of 60 participants from three equal groups; Group 1- Normal volunteer knees (n = 20), Group 2 – Flat Oxford Lateral UKR’s (n = 20) and Group 3 – Domed Oxford Lateral UKR’s (n = 20). The sagittal plane kinematics of each involved knee was assessed continuously using videofluoroscopic analysis. A standardised protocol of step-up and deep lunge was used to assess loadbearing range of motion during which the patella tendon angle (PTA) was measured as a function of the knee flexion angle (KFA).

Results: PTA/KFA values compared at 10 degree KFA increments from maximal extension to maximal flexion for all 3 groups did not demonstrate any statistically significant difference in PTA values between any group as measured by a 3-way ANOVA. The Domed implant achieved higher maximal active flexion during the lunge exercise than those with a Flat implant. Only 33% of the Flat UKR’s achieved KFA of 130 degrees or more under load whilst performing a lunge, compared with 75% of domed UKR’s and 90% of normal knees. No Flat UKR achieved a KFA of 140 degrees or more, yet 50% of all domed UKR’s did, as also did 60% of all normal knees.

Conclusions: There is no significant difference in the sagittal plane kinematics of the domed and flat Oxford UKR’s. Both implant designs have a favourable kinematic profile closely resembling the normal knee. The domed knees though do have a greater range of motion under load as compared to the flats, approaching levels seen with the normal knee.


C Huber M Kelly T Lautenschlager BS Noble H Simpson

Over 1 million fractures occur each year in the UK. Approximately 5-10% of these fractures have problems with healing. The treatments used for these patients often have a poor outcome and are associated with increased morbidity and disability. Application of synthetic peptides such as thrombin degradation peptide (TP508) has been shown to accelerate fracture repair in a closed rat femoral fracture model. Controlled release of TP508 using microspheres has been shown to enhance repair of articular cartilage defects and stimulate bone formation in segmental defects in rabbits. The aim of this study was to determine whether TP508 could bring about healing in an established fracture non-union model.

A validated rat model of fracture non-union was used. The model was created and left for 8 weeks in order to represent a clinically equivalent model of a non union of a fracture. Rats were randomised into two treatment groups receiving 10microg and 1microg doses of TP508 diluted in 50microL of microspheres and delivered directly to the non union site using percutaneous injection 8 weeks after surgery. The control group received no treatment. At 16 weeks post-surgery, osseous bridging was assessed both radiographically and histologically.

Radiographically there was no difference between the control and two treatment groups. However, histomor-phometric analysis demonstrated that bone formation increased by 43.9% in animals that received high dose of TP508 compared to the control animals. The analysis also indicated that administration of the low dose of TP508 increased the amount of bone formation compared to the control by 9.9 %.

Administration of TP508 has been shown to enhance healing of segmental defects in both critically and noncritically sized defects. However, in our model which is an established fracture non-union model, TP508 did not manage to achieve full osseous union. It has been suggested that the action of this peptide is concentration and environment dependent possibly indicating that TP508 might be less effective when administered in a chronic situation such as that associated with the established non-union fracture. However, even in this sub-optimal situation an increased amount of bone formation was observed.


M Rathinam IP Pengas A Hatcher MJ McNicholas

Aims: To assess the results of Anterior Cruciate Ligament (ACL) reconstruction at a minimum of two years follow-up, using the Rolimeter [AIRCAST, Europe] as an adjunct to routine knee examination and subjective scoring systems.

Methods: The Warrington Knee Injury database was initiated in June 2001 and data from all knee ligament injuries has been collected prospectively, from preoperative status through to all follow up assessments. Inclusion criteria for our study were, all ACL reconstructions performed by the senior author with minimum 24 months follow up; other ligaments being intact and presence of a normal contralateral knee.

50 patients satisfied the inclusion criteria. There were 41 males and 9 females in ages ranging from 17 to 51 (mean 30.6 years), with no significant difference in age between sexes. Hamstring grafts were used in 29 knees and Bone-Patellar tendon – Bone (BPTB) grafts in 21. Knee laxity was measured using the Rolimeter with IKDC knee examination and functional assessments using the Lysholm, IKDC and KOOS scoring systems.

Results: 20/21 of patients with BPTB grafts (95.2%) and 26/29 of patients with Hamstring grafts (89.7%) achieved normal or near normal knee laxity compared to their opposite knee. The Range of movement in 48 of 50 knees (96%) fell within normal or near normal limits according to IKDC description (Lack of extension < 3 degrees and lack of flexion < 10 degrees). Two patients with abnormal range of movement had a similar lack of movement preoperatively. Though none of the knees were abnormally tight (AP laxity difference < -3), there was a relationship between knee tightness and lack of extension, but this was not statistically significant. There was no association between age or sex of patient and lack of movement. The mean IKDC, Lysholm and KOOS symptom scores were 80.45, 87.3 and 81.3 respectively.

Conclusions: We have achieved a normal or near normal AP laxity in 92% of our ACL reconstructions on assessment at 2 years postoperatively. We report no signifi-cant difference in outcome between use of Hamstring or BPTB grafts. The functional outcome has been optimal as revealed by subjective evaluation.


XC Wei

To explore the relationship of hyaluronan level in synovial fluid of the knee with the degree of synovitis and cartilage injury.

A total of 104 knees in 102 patients with knee osteoarthritis or other knee diseases was studied. The hyaluronan level in the synovial fluid of the knees was measured with enzyme linked immunoassay. The pathology of the synovium and articular cartilage was evaluated with Ayral’s score system and Outerbridge’s score system under arthroscopy. The data were analyzed by t’-test or nonparametric test, ANOVA, Pearson or Spearman correlation and multiple liner regression.

The results showed that the hyaluronan level in the synovial fluid of the knees was correlated positively with Ayral’s score (beta’A=0.497, P< 0.001) and negatively with accumulative Outerbridge’s score (beta’O=-0.364, P< 0.001), especially Ayral’s synovitis score in 104 cases. The hyaluronan level in the synovial fluid of the knees was higher in those with Ayral’s score > and = 60 than in those with the score< 60 (P< 0.001). The hyaluronan level in the synovial fluid of the knees was lower in those with accumulative Outerbridge’s score > and = 10 than in those with the score < 10 (P< 0.05). The level of hyaluro-nan in the synovial fluid in the knees with Ayral’s score > and = 60 was correlated negatively with accumulative Outerbridge’s score (beta’O=-0.437, P< 0.001) and positively with Ayral’s score (beta’A=0.339, P< 0.01), especially accumulative Outerbridge’s score.

Compared with other knee diseases, the hyaluronan level of OA knees was lower (P< 0.05). However, Ayral’s score and accumulative Outerbridge’s score were higher in OA knees (P< 0.001).

The hyaluronan level in the synovial fluid of the knee can reflect the degree of synovitis and accumulative cartilage injury, especially synovitis. It reflects the degree of accumulative cartilage injury mainly when synovitis is more severe. The decrease of the hyaluronan level in the synovial fluid of OA knee is results of integrating effect of the synovitis and cartilage injury.


SY Mitchell AW McCaskie RM Francis RT Peaston FN Birrell EA Lingard

Background: Falls are a major concern in the elderly population both from a clinical perspective and that of health resource provision. This study evaluates the incidence of falls in patients awaiting hip or knee replacement and the impact of joint replacement surgery 2 years later.

Method: Patients aged 65-80 years listed for primary hip or knee arthroplasty for osteoarthritis (OA) were invited to participate. Patients completed a questionnaire including Western Ontario and McMaster University OA Index (WOMAC) scores 0-100, 100 best, history of falls and fractures. Function was measured using Timed Up and Go (TUG) walk test. All tests were repeated at two years.

Results: One hundred and ninety-nine patients (84 hips, 115 knees) were recruited with a mean age of 72 years (standard deviation 4.0) and predominantly female (57 %). At two years 144 patients were reviewed of whom 128 had undergone arthroplasty. After surgery, 29/128 (23%) reported falling compared to 55 of these 128 (43%) falling at baseline; only 13/128 (11%) had fallen more than once. Fifteen patients sustained minor injuries and one patient reported a fractured wrist. Of the patients who had undergone joint replacement and fell at baseline 36/55 (66%) patients reported no falls at follow-up, whilst there were 11 new fallers. Patients reporting falls had significantly lower WOMAC pain and function scores, and slower TUG scores at both baseline and two-year review.

Conclusion: Patients with severe hip and knee OA awaiting arthroplasty reported a higher incidence of falls compared to the normal population but reported fewer falls after surgery. However, almost one in four patients were still reporting falling at the two-year review. Injury including periprosthetic fractures can have serious clinical and economic consequences. This study highlights the need to evaluate a falls prevention programme in arthroplasty management.


E Robinson E Baggs P Brettle F Birrell MR Reed

Background and objective: in 2003 in its publication ‘Care of fragility fracture patients’ The British Orthopaedic Association highlighted the orthopaedic surgeon’s role in assessment and management of patients at high risk from osteoporosis. In general such secondary prevention of osteoporosis is carried out poorly by orthopaedic surgeons. This audit aimed to determine if software which identifies patients at high risk from osteoporosis from clinic letters, improves orthopaedic surgeons’ referral rates for DEXA.

Methods: two audit cycles were carried out using local guidelines. The audits concerned patients over 50 years having sustained a fragility fracture of the distal radius. According to local guidelines all such patients should undergo DEXA. Patients were identified from hospital records and the number referred for DEXA determined. Those who had undergone DEXA in the year prior to fracture were excluded. The baseline audit was from April to June 2004 inclusive followed by closure of the loop between October and December 2004 following reinforcement of guidelines. Following continued poor referral rates at this point the software programme was introduced. It identifies patient age and key words in dictated clinic letters when they are being printed, for example distal radial fracture. Appropriate patients have computer generated osteoporosis advice included at the bottom of the general practitioner letter along with a DEXA referral form which General Practitioners complete. A further audit using similar methods was carried out 3 months after the software introduction (January 2006).

Results: baseline audit identified forty-three patients (36 women and 7 men) with a mean age of 73 years, 3 were referred for DEXA (7%). Following reinforcement of guidelines fifty-two patients were identified (46 women and 6 men) with a mean age of 68 years, 16 (31%) were referred. At re-audit (following the introduction of the software programme) 45 patients were identified (38 women and 7 men) with an average age of 71 years. 30 (67%) were referred for DEXA. This is a significant improvement using a Chi squared analysis.

Conclusion: the software programme significantly improves orthopaedic surgeon identification of patients at high risk of osteoporosis and referral rates for DEXA.


A Shoaib U Rethnam R Bansal A De

Introduction: The mini C arm is a surgeon operated fluoroscopic device for use in the operating theatre for extremity orthopaedic surgery. There have been no studies comparing the radiation dose of the mini C arm and the conventional C arm.

The aim of this study was to determine if the exposure to patient and surgeon was decreased with use of the mini C arm.

Methods: This was a case-control study. Operations performed with the mini C arm were matched for type, complexity and operator with cases performed with the conventional C arm. The number of exposures and the total time of exposure were measured, and the skin dose and scatter calculated.

Results: There were 16 case-control pairs. There was a significantly greater number of exposures taken by the surgeon operated mini C arm (p=0.02), but there was still a significantly lower exposure to the surgeon with the mini C arm (p=0.004). There was no significant difference in the patient skin dose (p=0.21).

Conclusions: The surgeon operated mini C arm results in a greater exposure time and number of exposures. Despite this, the mini C arm exposes the surgeon to less radiation compared to the conventional C arm in extremity orthopaedics. The radiation exposure with the mini C arm is approximately half that of the conventional C arm. The increased number of exposures may occur because surgeons are more trigger happy with the mini C arm, or because there are technical problems with achieving a useful image. The mini C arm should be used for extremity orthopaedics whenever possible to decrease the radiation exposure.


P73 Pages 386 - 386
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ABSTRACT WITHDRAWN


IM Stevenson AJ Johnstone

Restoration of normal anatomy following a distal radial fracture is an important factor in determining functional recovery. However, current methods of assessing dorsal tilt and displacement require ‘true’ lateral radiographs, and important reference points are often obscured by metalwork.

Aims: to investigate if an easily identifiable and predictable relationship exists in the normal wrist between the distal radius and lunate; and if so,to compare fractured wrists (pre and postoperatively)using conventional and new assessment methods.

22 patients with displaced distal radial fractures treated by ORIF, were included. Patients had pre and postoperative radiographs taken of the injured and uninjured wrists. From lateral radiographs, measurements were performed using the PACS system. A line was superimposed upon the dorsal radial cortex 2cm proximal to the wrist passing distally. The following measurements were performed: lunate height, distance from the ‘line’ to the superior and inferior poles of the lunate, and conventional measurements of dorsal tilt and angulation.

Uninjured wrist: Most noticeably the dorsal radial line always passed superior to the lunate, mean distance of 3.27mm (1.75-6.6mm). As a ratio, the distance from the line to the superior pole of the lunate divided by the distance to the inferior pole (‘lunate ratio’) had a mean of 0.16 (0.11-0.19).

Fractured wrist, PreORIF: Using conventional methods, the mean fracture displacement was 2.64mm (0-5.1mm) and the mean dorsal tilt was 23.3 degrees(4 degrees volar tilt to 43 degrees dorsal tilt). Using the dorsal reference ‘line’, in all cases the lunate was either above or transected by the line; mean lunate ratio of 1.61 (0.54-8.05). The mean height of the lunate projecting dorsal to the line was 9.5mm (6.1-16.1mm).

Fractured wrist, PostORIF: Apart from one radiograph, the ‘line’ passed superior to the lunate; mean distance of 2.64mm (0-3.9mm), with a mean lunate ratio of 1.13 (0.61-2.74). These measurements correlated well with measurements of dorsal tilt and displacement.

Our study suggests that there is a strong relationship between the distal radius and the lunate that could be used to assess fracture displacement and quality of reduction. Its main advantages are simplicity and ease of use despite the presence of metalwork.


O Alizadehkhaiyat JG Kemp K Vishwanathan SP Frostick

Purpose: It is known from the literature that gripping, which is commonly used in various work-related, sport-related, and daily activities, activates both wrist extensors and flexors. Pain aggravation occurs during grip due to over-exertion of the extensor muscle group in lateral epicondylitis and grip strength is reduced. Of grip strength studies, few studies have simultaneously investigated muscular response using electromyography as a method of monitoring muscular fatigue or muscular activity of forearm muscles. The fatigability and activity of wrist antagonistic muscles in patients with lateral epicondylitis has not been previously investigated.

Methods: 16 tennis elbow patients (Tennis Elbow Group) and 16 healthy volunteers (Control Group) were participated in this study. In both groups, local muscular fatigue and muscular activity were measured for 3 forearm muscles contributing to the wrist extension and 2 muscles contributing to the wrist flexion using EMG and during gripping at 50% maximum voluntary contraction (MVC). Fatigability and activity of muscles then were compared between control and tennis elbow groups.

Results: Grip strength was significantly lower in tennis elbow group than that in control group (p < 0.05). Median frequency (MDF) and root mean square (RMS) of electromyographic signals were used as parameters to measure muscular fatigue and muscular activity, respectively. Further analysis showed no significant difference in the fatigability of forearm muscles between two groups. The activity of Extensor Carpi Radialis (ECR) showed statistically significant reduction in tennis elbow group compared to the control group (p < 0.05).

Conclusion: This is the first study to simultaneously investigate the fatigability and activity of the forearm antagonistic muscle groups in patients with lateral epi-condylitis. The fact that ECR showed similar level of muscular fatigue to other muscles despite decreased muscular activity may indicate of higher fatigability of this muscle in tennis elbow. Furethermore, decreased muscular activity of ECR may be a part of mechanism to protect the muscle from further injury in tennis elbow patients.


A Murgia P Kyberd T Barnhill

Aims: To detect discriminant features in the cyclic kinematic patterns generated during selected upper limb activities of daily living by a normative and a distal radial fracture group, so as to reduce the multidimensionality of the kinematic analysis.

Methods: Cyclic activities of daily living were performed using a protocol that allowed comparison between the resulting kinematic patterns or waveforms. Twop groups were measured:

Group A: 11 subjects with normal hand function (average age: 31.5ys, SD: 8.7ys).

Group B: 5 subjects having undergone treatment for distal radial fracture was tested using the same methods (average age: 34.2ys, SD: 16.8ys).

Task presented here, (one of 5) performed by turning a key 90 degrees clockwise. Principal component analysis (PCA) was applied to the waveforms of group A, using the procedure illustrated by Deluzio et al.,1997 for use with walking gait patterns. A 90% trace criterion was used to calculate the number of principal components (PCs) to retain.

Results: Looking at elbow pronation/supination (PS). Two PCs were retained. The first component consisted of a simple pronation pattern. The opposite signs of Y1 differentiated left-hand users (utmost right), who required pronation to rotate the key, from right-hand ones, who required supination, with the exception of subject 3 group B. The second component consisted of pronation (cycle first half) followed by supination (second half). Subject 3 stood out because of limited elbow supination, which resulted from the combination of pronation (Y1) and supination (Y2) components.

Conclusions: Upper limb analysis can employ the statistic tools of gait analysis provided a cyclic and repeatable protocol is used. PCA was applied to elbow PS to identify statistically different movements of the distal radial fracture group and underline their main characteristics. This is particularly important in the presence of a large data group, when the identification and evaluation processes need to be both rapid and accurate. Limited PS was identified as a discriminant feature, supporting the follow-up studies for this injury that measured a reduction of PS by about 80% compared to that of the unaffected side. The cycle stages concerned can be identified on the basis of the contribution given by each component.


SPK Morapudi E Oh IJ Braithwaite

Intra-articular steroid injection has been widely used for relief of pain in Osteoarthritis. Recent studies show an increasing rate of infection in these patients following hip arthroplasty. We have reviewed our cohort of patients to see if they are susceptible to higher infection rate.

We reviewed a cohort of 167 consecutive hips that had at least one injection with a 40mg triamcinolone acetonide and 4ml 0.5% bupivacaine mixture to relieve the symptoms of hip osteoarthritis or to clarify a diagnosis of hip arthritis between January 1997 and Novem-ber 2004 were reviewed. A total of 37 hips (36 patients) that subsequently proceeded to have a total hip arthroplasty were selected as our study group. There was a minimum of a one-year follow up.

The rate of infection in our initial cohort of patients following a hip injection was 0.60% (1 hip) which resulted in repeated washouts and a subsequent total hip arthroplasty with a good outcome. On review of the 37 hips, one was revised due to a deep infection secondary to staphylococcus epidermidis. Four were revised for continued instability and pain with no evidence of infection either prior to or during revision. When deep infection is taken as an endpoint, cumulative survival at 7.5 years is 0.968 (95% confidence interval of 1 to 0.905). The total survivorship of this cohort if all revisions are included is 0.852 at 7.5 years (95% confidence interval of 0.730 to 0.974). The revision rate due to a deep infection in our study is 2.7%.

We conclude that patients who have a total hip arthroplasty after a hip injection do not have an adversely high rate of deep infection.


M Khan JH Kuiper E Robinson JB Richardson

The Trent arthroplasty register reported that results of Hip arthroplasty in general setup were less than that reported from specialist centres by 5%. This independent prospective study tests the hypothesis that results of Birmingham Hip Resurfacing (BHR) arthroplasty from pioneering centres would not accurately represent the outcome of hip resurfacing when performed in general setup.

All patients were prospectively followed for at least five years at Oswestry Hip outcome centre. The surgeons carrying out the operation prospectively provided surgical details and thereafter patients were followed using Oswestry hip questionnaire (OSHIP) at fixed intervals. Survival was assessed by Kaplan-Meier method. Results were compared to the published results of BHR from specialist centres.

There were 679 patients, and 58 surgeons in the study. Mean age at operation was 51 years and mean follow up was 5.63 years. The predominant preopera-tive diagnosis was Osteoarthritis. Mean OSHIP score was 89.5. There were 29 (4.2%) failures mostly due to fracture neck of femur (34%). Out of 14 failures in the first year, 9 (64%) were due to fracture neck of femur. The Kaplan-Meier survival up to eight years is 95.354% in the current study.

Compared to the published results, there were 2 to 19 times high failure rate which is significantly higher (p=0.001) than the published studies. Most of the early failures were due to fracture neck of femur in the first year. Hence we prove our hypothesis, as the results of BHR from specialist centres do not accurately reflect on the outcome in general setup. The discrepancy in the results is mostly due to fracture neck of femur in the early postoperative time. The results of this study will enhance awareness of the early trend in failures. Appropriate patient selection and meticulous surgical technique will help avoid this complication in the general setup, where most of the patients get benefited from BHR arthroplasty.


A Yousef RK Pagoti RK Morisetty P Bolton

Aims: Hypokalemia is a common electrolyte imbalance with signficent effects. The aim of our study is to identify incidence, causes and prognostic implications of postoperative hypokalemia in elderly patients operated for fracture neck of femur.

Methods and material: Retrospective study, of 404 consecutive fracture neck of femur patients who were operated in our hospital between October 2001 and July 2003. Patients identified with postoperative hypo-kalemia the medical notes, fluid charts and anaesthetic notes were analysed for age, preoperative morbidities, medications, mechanism and type of injury, waiting time for operation, pre, peri and postoperative fluid management, type of anaesthesia, operative time, hospital stay and mortality.

Results: Out of the 404 patients, 54(13.3%) were hypokalemic (K< 3.5mmol/l) postoperatively. Of the 54 patients 16 (29.6%)had preoperative hypokalemia.

Among the hypokalemic group the mean preopera-tive potassium was 3.69mmol/l and the mean postoperative potassium was 3.19mmol/l. The t-test showed a statistically significant difference between mean pre and postoperative potassium levels (P< 0.0001). High association was found with hypokalemia and post-operative dextrose infusion (38%). 50% of patients on diuretics developed hypokalemia post operatively. Interestingly, only 18% of these were hypokalemic pre operatively.

In patients with multiple medical problems, like diabetes, hypertension and CVA, high incidence of hypokalemia was found. (38% had 2 or more medical problems).

No significance in the mortality rate was found in fracture neck of femur patients with and without postoperative hypokalemia (40% vs. 39% at 3yrs).

Conclusion: There is significant risk of hypokalemia following orthopaedic surgery, especially in the elderly. This avoidable condition, which has serious consequences, should be dealt with care in the orthopaedic units. Fluid infusion regimes and should be formulated and medications reviewed to prevent conditions like hypokalemia.


RK Trehan G Kumar A Shetty V Naidu

The authors report the use of a modified ‘Y-V’ medial capsular repair in association with Scarf osteotomy for Hallux valgus in 55 patients (62 feet) aged 18 to 61 years (mean 43 years) between July 2004 and July 2005. All patients were followed up for minimum 6 months by questionnaire, physical examination (American Orthopaedic Foot and Ankle Society score) and comparison of preoperative and post operative x rays.

Using this technique none of the patients required an additional proximal phalangeal osteotomy (Akin Oste-otomy). At six months follow up American Orthopaedic Foot and Ankle Society score improved from 46 to 87. Intermetatarsal (IM) angle and the hallux valgus (HV) angle improved from 16 degree to 9 degree and from 31 degree to 16 degrees respectively (p less than 0.05).

Of the sixty two procedures 59 did not develop any complications. Two had superficial infections which required oral antibiotics only. One partial loss of correction of hallux valgus occurred for which the patient refused a second operation. Seven cases had some residual pronation deformity of the big toe identified by the patients who felt the deformity was ‘about 50%’ compared to before the operation.

Akins osteotomy achieves an apparent correction of hallux valgus without addressing subluxation of meta-tarso-phalangeal joint. Our technique reduces the meta-tarso-phalangeal joint and corrects the hallux valgus angle anatomically.

We recommend the use of this modified ‘Y-V’ medial capsular repair to correct the hallux valgus angle and reduce the need for an additional procedure to augment the correction achieved during Scarf osteotomy for hallux valgus.


AM Byrne SR Kearns SH Orakzai P Keogh SJ O’Flanagan

With the increasing availability of magnetic resonance imaging, there is potentially less emphasis being placed on making a definitive clinical diagnosis. Changes in the undergraduate curriculum have also reduced the emphasis on orthopaedic clinical evaluation. This aim of this study was to evaluate the predictability of clinical examination alone in comparison with arthroscopic findings in 50 consecutive patients presenting for arthroscopy to our service. Four trainees examined each patient; each examiner was blinded to the clinical diagnosis made by their colleagues. All patients were examined in the ward and subsequently underwent examination under anaesthesia and arthroscopy.

Of the tests for meniscal injuries joint line tenderness was the most sensitive (77%) and specific (68%). Apley’s and McMurray’s test while specific (92%, 98%) lacked sensitivity (9%, 30%). Overall the tests for anterior cruciate ligament (ACL) disruption were more reliable than the tests for meniscal injuries. The anterior drawer and Lachmann tests had high specificity (90%, 75%) and sensitivity. The pivot shift test also had very high specificity (75%) and sensitivity (98%) for detecting ACL injuries. These data demonstrate that joint line tenderness is the most reliable sign of menis-cal injury. In the absence of joint line tenderness Apley & McMurray’s tests have little role in routine clinical examination. Clinical tests and signs of ACL deficiency are consistently reliable in diagnosing ACL rupture.


E Robinson P Partington

Aim: to compare the reliability of pre-operative templating for total hip and knee arthroplasty using printed digital radiographs versus conventional radiographs.

Materials and Methods: a prospective continuous study commenced January 2005. The PACS digital imaging system was introduced in May 2005 and the radiology department adopted a policy of printing orthopaedic radiographs to ‘true size’. All consultants and their registrars undertaking primary total hip and knee arthroplasty were asked to participate in the study and agreed. The operating surgeon completed a proforma for each Total Hip Replacement (THR) performed noting the templated cup and stem size and offset. Following the surgery the actual sizes and offset of the components implanted were also recorded on the proforma. A similar procedure was followed for the femoral and tibial components of Total Knee Replacements (TKR).

Results: there were 254 completed proformae. 186 pro-formae for conventional radiographs and 68 proformae for printed digital radiographs. Templating was possible from all the conventional radiographs; however templating was only possible from 58 of 68 (85%) digital radiographs as the images were obviously not true size. The templated sizes of both hip and knee components from conventional radiographs were more predictive of the actual size implanted in all cases. Furthermore there were a greater number of predicted outlying sizes using printed digital radiographs.

Conclusion: digital radiographs, even those said to be true size are unreliable for the purposes of pre-operative planning.


MC Rao JH Kuiper CP Kelly

Purpose: To find if there is any difference in gapping of tendon repair on cylcic loading and energy to failure of tendon repair when the circumferential suture knot is placed on the same side of the core suture knot or to the opposite side of the core suture knot.

Methods: Ten pig flexor tendons were repaired using 3 0 braided Polyester (Ethibond) as core suture (modified Kessler) and 6 0 Nylon as circumferential stitch (Hal-stead). Five tendons were repaired with the circumferential suture knot placed on the same side as the core suture (Group I) and the other five placed on the opposite side (Group II). Allocation to either of the groups was random. Using a testing machine the tendons were cyclically loaded and the energy to failure was calculated. Gapping during cylical loading was recorded using digital images.

Results: Mean gapping in Group I was 0.01 mm and in Group II was 0.03mm. This was not statistically signifi-cant (2x3 ANOVA, p > 0.3). The mean load to failure in group I was 58.7 N (55 to 65) and in group II was 59.5 N (54 to 67). This was also not statistically significant (p > 0.3 one way ANOVA).

Conclusion: There is no difference in gapping and energy to failure of tendon repair when the circumferential suture knot is placed on the same side of the core suture knot or to the opposite side of the core suture knot.


B Devitt J Street J S Butler D McCormack J O’Byrne

The purpose of this study was to review the early results of a consecutive series of patients undergoing periac-etabular osteotomy (PAO) at Cappagh National Orthopaedic Hospital. The procedure was first carried out in 1998, and a total of 85 PAOs have been performed in 79 patients. The mean follow-up was 42 months (range 6-84 months). There were 72 females and 7 males with a mean age at the time of the operation of 22.9 years (range, 14-41 years). The preoperative diagnosis was developmental hip dysplasia in 80 hips, Legg-Calve-Perthes disease in one hip, congenital coxa vara in three hips, and slipped capital femoral epiphysis in one hip. The average Merle d’Aubigne score increased from 12.4 points preoperatively to 16 points at latest followup. The lateral center edge angle of Wiberg was between – 20 and +28 before surgery and was improved from 12 to 48 (average 30 degrees) following PAO. While, the anterior center edge angle of Lequesne and de Seze was between – 22 and +35 preoperatively and was improved by an average of 28 degrees (range, 17 – 40) postoperatively. The acetabular index angle decreased from an average of 24.8 preoperatively to 8.4 postoperatively. Clinical follow-up revealed that 77% of patients had no or mild pain, 33% of patients had a limp and 64% of patients were unlimited in physical activity, representing a markedly improved clinical outcome. Four patients underwent subsequent total hip arthroplasty. The short term results in this group of patients treated with PAO show reliable radiographic correction of deformity and improved clinical scores. The study reflects the learning curve associated with performing this procedure and the results that can be expected with a smaller clinical case-load than described in previous studies. We suggest that PAO may safely be carried out at a non-super-specialized institution provided the surgeons have sufficient experience and patients are selected appropriately.


BH Van H Pandit J Gallagher HS Gill AB Zavatsky NP Thomas DW Murray

Introduction: The cam-post mechanism of Posterior Stabilized Total Knee Arthroplasty (PS-TKA) should provide a constraint that limits anterior translation of the femur on the tibia in flexion and thereby ensure femoral roll-back with progressive knee flexion. In a previous fluoroscopic study we showed that the sagittal plane kinematics of a PCL substituting TKA (Scorpio PS) was abnormal in flexion, suggesting inefficiency of the cam-post mechanism. We also assessed the movement of the femur relative to the tibia using the Patella Tendon Angle (PTA) through the range of knee flexion (0 to 90 degrees). The aim of the current study was to investigate in greater detail why the cam-post mechanism was ineffective by assessing the contact point movement and the distance between the cam and post.

Method: Twelve patients with Scorpio PS TKA underwent fluoroscopic assessment of the knee during a step up exercise and a weight bearing deep knee bend. The image distortion was corrected using a global correction method and the data was analysed using a 3D model fitting technique. Having determined the component position, the minimum distance between cam and post were determined. The femoro-tibial contact positions of the medial and lateral condyles were determined relative to the mid-coronal plane of the tibial component. The PTA was calculated by measuring the angle subtended by patella tendon with the tibial axis and was plotted against knee flexion angle (KFA).

Results: The relationship between PTA and KFA was abnormal relative to the normal knee. Between extension and 60 degrees flexion there was forward movement of both medial (11 mm) and lateral (5 mm) femoral condyles. Thereafter, both condyles moved back (10 mm). The cam-post mechanism failed to engage in one case while in others it engaged between 70 to 100 degrees.

Conclusions: The 3D analysis has confirmed the preliminary findings of the previous study using the PTA and KFA relationship. Despite the cam engaging in flexion normal knee kinematics were not restored. The femoral roll-back is inadequate and starts to occur at least 20 degrees before the cam and post engage.


AL Dolan S Lockwood P Vandenbosch

Many osteoporosis units are now identifying low impact fracture patients at presentation and assessing them for osteoporosis risk using a nurse led fracture liaison service (FLS); we established such a service in July 2002. Unfortunately many patients previously admitted with hip fractures have never been assessed, but are at high risk of future fracture. Outlined below is an audit of case finding using the theatre database to identify these patients.

All fractured neck of femur cases from 1999 to 2002 were identified on a theatre excel database. We utilised our Hospital Information Services System (HISS) to exclude those who had subsequently died. Current address and other personal/GP details were also found using HISS. Patients under 80 years of age received a questionnaire on osteoporosis risk factors, treatment and subsequent fractures and were invited for a Dexa scan.

Results: 675 patients were identified, of which 291 (43%) died. We were unable to obtain details on 74 (11%) patients. 96 patients under 80 years were invited for a Dexa. 45/96 replied to the letter, 36/45 agreed to a scan. 9/45 declined. Only 6/96 had a scan from GP previously & 8 had been commenced on therapy since fracture (3: Calcium/D3 supplements, 4: bisphosphonates and 1: both). 32 had a Dexa following the audit (M/F – 9:23). 4 (11%) did not attend. 21 (65%) were osteo-porotic, of which only 2 were taking bisphosphonates & 1 calcium/D3. 11 (34%) were osteopenic of which 1 was on Calcium/D3 and 10 had no treatment.

Although this is quite a labour intensive intervention, it did identify many untreated osteoporotic patients who were a high risk of future fracture. It also highlighted the small number of patients who are referred for Dexa or commenced on treatment by their GP following the fragility fracture. We would recommend this strategy to other units for case finding. This emphasizes the importance of a FLS and the need to have active ways to implement NICE guidance.


E Byrne C Evans C Hutchinson S Kahn

The Ilizarov frame is a circular external fixator, invented by Professor Ilizarov in Siberia during the 1950’s. It uses the principle of distraction osteogenesis to form new bone in a variety of clinical situations where bone lengthening or realignment is needed. The Ilizarov frame began to be used in western medicine during the 1980’s and by 1993 over 6000 cases had been performed in Europe.

Plain x-ray is one of the methods used to monitor the progress of patients fitted with an ilizarov frame.

The aim of this study is establish a pattern of healing over time in patients with the Ilizarov frame using plain x-ray films. This will improve understanding of the procedure, aid clinicians in deciding when frame removal is appropriate and provide a method of early detection should healing not be progressing appropriately.

This is a retrospective study looking at a series of 58 digitised anterior-posterior x-ray films of the tibia and fibula, taken at set time points post-operatively, from 17 patients fitted with an ilizarov frame (19 separate legs with ilizarov frames in total). Image J, an image analysis system, was used to measure pixel density from vertical slices down the centre of each fracture gap and at set intervals horizontally across the fracture gap. A mean pixel density value for each fracture gap was also calculated. The x-rays were standardised using a standard step wedge.

Promising preliminary results show pixel density to be greater towards the medial aspect of the tibia, but this difference in pixel value decreases with time. This suggests that calcification of the new bone occurs medially to laterally across the tibia. Full results will be available in April and aim to build a picture of the fracture gap at set time points post-operatively, showing a pattern of calcification in patients with the Ilizarov frame that will become a useful clinical tool for deciding time of frame removal as well as affording early knowledge of problems with the healing process.


SV Deshpande G Macken A Kedgley JA Johnson DG Chess

Introduction: Optimal soft tissue tension maximises function after total knee arthroplasty (TKA). Excessive tension may lead to stiffness and or pain, while inadequate tension can lead to instability. Composite component thickness is a prime determinant of this soft tissue tension. The variable component thickness provided by polyethylene inserts generally allows for 2-3 mm incremental change. This study analyses the effect of incremental change in polyethylene thickness on soft tissue tension.

Methodology: Computer assisted (Stryker Knee Nav) TKA was performed on 8 cadaveric knee specimens (4 pairs). Kinematic data was collected through the navigation software. The soft tissue tension was analysed by measuring compartmental loads. A validated load cell instrumented tibial insert was used to measure medial and lateral compartmental loads independently. The effect of 1mm increments in polyethylene thickness on compartmental loads was evaluated.

Results: We measured an increase in compartmental loads with increasing insert thickness. However the peak loads in each compartment showed different behaviour reflecting varying tension in the medial and lateral sides. The peak loads generated also showed a reduction after reaching a maximal level with further increase in insert thickness. With a 1 mm increase in insert thickness, 50 % of specimens showed greater than 200 % increase in the peak loads in the lateral compartment.

Conclusions: The compartmental loads vary as a function of insert thickness. The high sensitivity of compartmental loads with a 1mm increment is significant and has not been previously appreciated, especially intraoperatively. The currently available TKA inserts with 2-3 mm increments may make obtaining optimal soft tissue tension difficult. In addition to the current focus of obtaining accurate leg alignment, further computer aided techniques are required to address soft tissue tension.


AD Gorva J Metcalfe R Rajan S Jones JA Fernandes

Introduction: Prophylactic pinning of an asymptomatic hip in SCFE is controversial. Bone age has been used as evidence of future contralateral slip risk and used as an indication for such intervention. The efficacy of bone age assessment at predicting contralateral slip was tested in this study.

Patients and Methods: 18 Caucasian children prospectively had bone age assessment using wrist and hand x-rays when presenting with a unilateral SCFE. Patients and parents were informed about the chance of con-tralateral slip and risks of prophylactic fixation, and advised to attend hospital immediately on development of symptoms in contralateral hip. After in-situ fixation of the affected side prospective monitoring in outpatient department was performed. Surgical intervention was undertaken if the contralateral hip was symptomatic.

Results: Three children (2 boys) went on to develop to a contralateral slip at a mean of 20 months from initial presentation. 6 children (5 boys) were deemed at risk of contralateral slip due to a bone age below 12.5 years for boys and 10.5 for girls. Only one from this group developed a contralateral slip. The relative risk of proceeding to contralateral slip when the bone age is below the designated values was 1 (95% confidence interval of 0.1118 to 8.95). The sensitivity and specificity were 33% and 66% respectively. With positive predictive value of 15% and diagnostic efficiency of 61%.

Conclusion: Delayed bone age by itself is not a good predictor of future contralateral slip at initial presentation. Routine prophylactic pinning is not justified based on bone age alone, with the risks of surgical fixation it carries. Prospective long term longitudinal study is required.


R Dath S Hazarika KM Porte AW Miles

The growing interest in the development of spinal implants has led to an increasing need for biomechanical studies. Porcine spines are commonly used in such studies. Quantitative data of the normal porcine tho-racolumbar spine is lacking, yet these data are crucial to discussion of such studies. In this study we aim to provide such a database to highlight the differences between the porcine and human specimen with a view to help plan future studies contemplating their use.

6 adult (18-24 month old, 60-80 kilograms) male porcine spines were dissected of soft tissue. The lowest thoracic and all the lumbar vertebrae were studied (n=42). 15 anatomical parameters from each vertebra were measured by 2 independent observers using digital calipers (Draper PVC150D, accuracy ± 0.03mm). The mean, SD and SEM were calculated using Micro-soft Excel. Results were compared with available data on human vertebra (Zindrick et al 1987;Panjabi et al 1991,1992; Kumar et al 2000).

The inter class correlation coefficient for the observers was 0.997. The intra-observer agreement was statistically robust (0.994). The vertebral body height of the porcine vertebra was larger while both the upper and lower endplate depth and width were smaller than the human specimens. The pedicle width and depth was greater than the human specimen. The spinal canal length and depth of the porcine spine were smaller than humans indicating a narrow spinal canal. The spinous process length showed an increase from T16 to L1. This was in contrast to human spinous process. The results for the measured parameters and their comparison to human specimen will be presented.

Results from our study provides a database of anatomical measurements for the porcine vertebrae and highlights the differences with the human specimen. The data would help design future studies contemplating the use of pig spines. Biomechanical studies involving interbody cages, disc replacements and pedicle screw systems should take into account the differences and match implant size accordingly. It also provides valuable information for geometric and Finite Element Modelling of the porcine spine. Further, the results are useful in extrapolation of data from experiments which have used the porcine model.


O Alizadehkhaiyat AC Fisher GJ Kemp SP Frostick

Purpose: It is known from previous studies that reduced grip strength is associated with tennis elbow; however; assessment of muscular strength over other parts of upper limb, particularly wrist and shoulder, has received a little or no attention in the literature. To address possible other upper extremity muscular strength weakness-imbalances in Tennis Elbow, this study aimed to investigate the strength of various upper limb muscle groups in tennis elbow patients and compare them with those of healthy subjects.

Methods: A total of 32 participants were assigned into two groups of Control (N=16) and Tennis Elbow (N=16). In both groups, upper limb maximal isometric muscular of dominant and non-dominant sides was measured at various joints including metacarpophalan-geal (extension & flexion), wrist extension & flexion), grip, and shoulder (internal and external rotation and abduction) using appropriate either commercial or purpose-built dynamometers. Muscular strength and important strength ratios were analyzed and compared in each group (dominant vs non-dominant) and also between Control and Tennis Elbow group using various statistical methods.

Results: Significant dominance difference was found in all strength measurements for Control group but not for Tennis Elbow group indicating a generalized and widespread upper limb muscular weakness associated with tennis elbow. In addition, significant differences were found not only for various hand strength measurements but also for shoulder strength between Control and Tennis Elbow groups (p < 0.05).

Conclusion: This is the most comprehensive study of upper limb isometric muscular strength assessment in Tennis Elbow during recent years. Distributed upper limb muscle strength weakness exists in Tennis Elbow which needs to be addressed within both preventative and treatment strategies.


A Yousef CR Pradhan PJ Livesley

The aim of the study was to measure the Quality of Life of young patients sustained fracture neck of femur.

This is a retrospective study of 50 patients who suffered different types of hip fractures. 67 patients underwent surgeries for hip fractures between 1998-2002 were sent the ‘EUROQOL EQ-5D’ questionnaire, out of which 50 replied back. Different parameters of EQ-5D including mobility, self-care, usual activities, pain / discomfort, anxiety / depression and the overall health status were graded by these patients. The overall scores were calculated. We compared those values with calculated EQ-5D values of control groups of the same age from the general population of the UK. Information about The type of fractures, the type of operation, complications, and the mechanism of injury were recorded and their effect on the quality of life was correlated.

Out of 50 patients, there were 29 male and 21 female, with a mean age of 48.52 yrs (16 to 60 yrs). There were 32 patients with intra-capsular neck of femur fractures, (16 undisplaced & 16 displaced) 17 intertrochanteric and one with a subtrochanteric extension. 16 patients underwent Internal fixation (AO Screws), 15 had a hemiarthroplasty, 18 had Dynamic hip screws and 1 had THR. The mean hospital stay was 7.14 days (3 to 28 days). 70% of the patients reported some problems with mobility, 44% had problems in self-care, 58% had a restriction of their usual activities, and 70% had pain & discomfort at an average of 4 years of follow up. When compared with same age groups from the general population there was statistically significant difference in the EQ-5D index and EQ-5D state with p value of [p=< . 05] in the patient aged between 30 and 60 and no statistical differences between the EQ-5D index or EQ-5D state in the age groups between 20 and 39. We also found an association between poor life quality and development of complications.

Complications included one dislocated hemiarhtro-plasty, one patient had AO screws removed.

Conclusions We concluded that fracture neck of femur in young patient lead to significant deterioration in patient quality of life when compared with the same age groups from he general population. More research is required to improve the current treatment methods.


J Newham R Pearson V Weston BE Scammell

Femoral head allograft bone used in complex orthopaedic surgery may transmit infection from donor to recipient. In order to minimise the risk all donors are serologically screened for Hepatitis B and C, HIV, HTLV, and syphilis at the time of donation and again at 6 months post-donation. Culture swabs are taken from the acetabulum and femoral head for 48 hour anaerobic and aerobic culture, and a sample of bone is incubated for 5 days in enrichment broth culture.

We have audited the culture results and screening tests performed in our bone bank from 2000 to 2005 inclusive.

1,528 allografts were received of which we had to discard 52 (3.4%) because of either positive cultures or serology. The vast majority of the positive cultures were due to S. epidermidis (30/43). All cultures were bacteria one might expect to find as normal skin flora. 3 patients had positive hepatitis C serology and 6 were syphilis EIA positive.

In May 2004 we decided in line with National Transfusion Guidelines for blood donation, to exclude donors who had had a blood transfusion since 1980 to mini-mise the risk of transmission of CJD. This and the opening of an Independent Treatment Centre (ITC) in our area drastically limited the number of possible donors to our bone bank. There was a significant reduction in the number of femoral heads received in 2004 and 2005 when compared with years 2000-2003 (p = < 0.00001).

We conclude that negligible numbers of femoral head allografts are lost due to our serological and microbio-logical screening tests. However measures introduced to limit the theoretical transmission of CJD via a bone allograft and the opening of a local ITC have had a huge impact on the number of potential donors available to us. To date the CJD prion has not been isolated from bone, but there have been 3 reported cases of transmission of infection by blood transfusion. We fear that the imminent introduction of a serological test for CJD will limit the number of possible bone donors even further.


SG Haidar CC Kat F Fatah SC Deshmukh

The purpose of this study was to assess shoulder function after breast reconstruction surgery using latissimus dorsi flap.

Sixty-eight patients (72 breasts) had this operation. Average follow up was 38 months (range 24 to 54 months). DASH and Constant-Murley were used for clinical assessment. Twenty-nine shoulders found to have a normal function; whereas, 11 shoulders had mild disability, 10 shoulders had moderate disability and 8 shoulders had severe disability. However, only 6 patients reported being unsatisfied with their outcome. Furthermore, all these 6 patients were not satisfied with their breast reconstruction outcome.

This study confirms that following breast reconstruction surgery using latissimus dorsi flap, there is a considerable deterioration of shoulder function of varying degrees. Nevertheless, shoulder function is not the main concern of this group of patients.


SP Krishnan A Bhadra NC Chayya JA Skinner RWJ Carrington TWR Briggs D Goldhill

Introduction and Aims: Allogenic blood transfusion is often required in lower-limb arthroplasty. The aims of this study were (1) to analyze the influence of anaemia on post-operative fatigue, hand grip strength, duration of in-patient physiotherapy and post-operative morbidity score (POMS) and (2) to investigate for prognostic factors to predict functional recovery following primary arthroplasty of the lower limb.

Patients and methods: This study was approved by the regional ethics committee. Two hundred patients (88 THR, 99 TKR and 13 hip resurfacing) were evaluated in this prospective trial. Blood haemoglobin concentration (Hb), hand grip strength and vigour scores using a validated fatigue questionnaire were estimated both preoperatively and at 3 days following surgery. Postoperative morbidity score (POMS) and the required duration of in-patient physiotherapy were also noted. The protocol for blood transfusion was for those with Hb less than 8 g/dL and/or post-operative symptoms attributable to anaemia.

Results: A greater fall in postoperative Hb correlated significantly with a greater reduction in post-operative vigour score (p=0.02). Also a greater fall in vigour score was found to correlate significantly with the duration of in-patient physiotherapy (p< 0.001). A reduction in Hb of > 4g/dL from the pre-operative Hb predicted a significantly higher reduction in vigour score (p=0.03). A weak correlation was seen between a fall in Hb and POMS (p=0.09).

A higher pre-operative Hb did not reduce the required duration of in-patient physiotherapy (p=0.72). There was no correlation between post-operative Hb and POMS (p=0.21) or required duration of in-patient physiotherapy (p=0.20).

A higher pre-operative grip strength predicted an early date of discharge by the physiotherapists (p=0.02).

Conclusion: We conclude that a fall in Hb of more than 4 g/dL has a detrimental effect on post-operative rehabilitation. Pre-operative grip strength measurements are valuable in predicting the rehabilitation potential of patients undergoing lower limb arthroplasty.


H Takano T Aizawa T Irie N Yamada S Kokubun

In the pubertal growth plate, sex hormones play important roles for the regulation of the proliferation, differentiation, maturation and programmed death of chondrocytes. Many studies have been reported on the regulation of oestrogen in long bone growth, however, some of the mechanisms have remained unclarified to date including its role for cell kinetics in the growth plate chondrocytes. The aim of this study was to clarify the effect of the deficiency of oestrogen on growth plate chondrocytes.

We obtained the growth plates of femoral head from the normal and ovariectomized Japanese white rabbits at 10, 15, 20 and 25 weeks. Ovariectomy was performed at 8 weeks. The cell kinetics of chondrocytes as defined by the numbers of proliferating and programmed dying cells was investigated using immunohistological methods.

The lengths of the femur were almost same both in the ovariectomised and normal rabbits. The height of the growth plate was larger in the former. The total number of chondrocytes in the ovariectomised rabbits was less than that of normal rabbits of the same age. Immunostaining of proliferating cell nucleous antigen (PCNA) showed a decrease number of proliferating chondrocytes and that of caspase-3 indicated a little increased number of apoptotic chondrocytes.

Oestrogen regulates endochondral bone formation through several pathways. It directly binds oestrogen receptor alpha and beta, and the former accelerates longitudinal bone growth whereas the latter represses it. Another pathway is through the GH-IGF-I axis: it closely interacts with GH and IGF-I for the control of longitudinal bone growth. In addition, there might be other mediators including transforming growth factor-beta, other IGFs and still unknown paracrine or auto-crine factors as IHH PTHrP. Our study suggests that in the rabbit growth plate during puberty, oestrogen mainly acts through the GH-IGF-I axis since its defi-ciency declined the proliferating ability of chondrocytes, which led the decrease of the number of chondrocytes.


R Raghunathan J Skinner F Pell

Objective: To investigate the possible effects of preop-erative Neuromuscular Electrical Stimulation (NMES) to the quadriceps and hamstrings for the patients undergoing Total Knee Replacement (TKR) during the immediate postoperative period. Design: Prospective, randomised controlled study. Participants: 36 patients with osteoarthritis(OA) of the knee who were waiting for the elective TKR were randomly assigned to 1 of 2 groups (18 per group): control and study group. The study group patients received NMES to the quadriceps and hamstrings preoperatively. One patient in the control group and five patients in the study group were excluded due to the following reasons: operation postponed (two), unicompartmental knee replacement was performed (one), patients not willing to continue to use NMES due to personal reasons (two) and inappropriate/unable to use NMES (one). Both the control and the study group patients received standard physiotherapy postoperatively. Intervention: NMES (100Hz frequency; 0 to 55 volts amplitude; 1 second on/1 second off stimulation protocol) to the quadriceps and hamstrings muscle groups for 3 to 6 weeks preopera-tively. Amplitude adjustments and usage timings were made by patients (at home) as dictated by the comfort level. Main outcome measures: Immediate postoperative assessment of straight leg raise, stair walking, flexion of knee, pain, walking distance, length of stay for rehabilitation and total length of hospital stay. Limitations: Small number of participants and only early followups were performed. Results: The outcome data suggest a possible benefit, but did not reach statistical significance in all but one parameter, early stair walking.


A Awad JG Andrew C Williams C Hutchinson

Measurement of the rate of fracture healing is a major problem in fracture research. Bone mineral density (BMD) of fracture callus has been used as a measure of healing in diaphyseal fractures. However, metaphyseal fractures (especially in the elderly) are now the commonest type of fracture and are a significant public health problem. This study investigated whether measurement of BMD at the fracture site in the distal radius can be used as a measure of fracture healing.

We recruited 28 patients who had sustained a dorsally displaced distal radial fracture which was deemed to require treatment by intrafocal wire fixation. All patients had acceptable correction of dorsal and radial angle at final x ray (3 months). Wrist function was measured using the Patient Rated Wrist Evaluation (PRWE – a validated outcome measure for use after distal radial fractures), grip strength,and range of motion. All measurements were made at 6, 12 and 26 weeks. BMD was measured at the fracture site (examining the BMD of the medullary bone at the fracture site after removal of wires), in the opposite wrist and the lumbar spine using QCT at 6 weeks after fracture.

There was no correlation between fracture site BMD and BMD at the other wrist or the lumbar spine (r < 0.3). The BMD at the fracture site was higher than the BMD at the other wrist (mean 168 vs 70 HU; p< 0.001 paired T test). There was no relationship between fracture site BMD or the ratio of BMDs fracture site / normal wrist, and any of the functional assessments (proportion grip strength recovered, range of motion or PRWE (r < 0.3)).

15 of these patients underwent a second QCT at 12 weeks after fracture. There was no significant change in fracture site BMD between the first and second scan.

These data indicate that fracture site BMD is unlikely to be a useful method of measuring metaphyseal bone healing. The increase in BMD at the fracture site was unexpected; possible explanations include impaction of bone or high BMD in woven bone (the relationship of which to bone stiffness is uncertain).


BA Rogers C Murphy SR Cannon TWR Briggs

Introduction: The load bearing status of articular cartilage has been shown to affect its biochemical composition. This study investigates the topographical variation of glycosaminoglycan (GAG) relative to DNA content in human distal femoral articular cartilage.

Methods: 26-paired specimens of distal femoral articular cartilage, from weight bearing and non-weight regions, were obtained from thirteen patients undergoing amputation. Following papain enzyme digestion, spectropho-tometric (GAG) and fluorometric (DNA) assays assessed the biochemical composition of the explants. Data was analysed using a paired T test.

Results: Despite no significant differences in absolute DNA concentrations, weight-bearing regions of articular cartilage showed a significantly higher concentration of GAG relative to DNA compared with non-weight bearing areas (p=0.021).

Discussion: This study suggests that chondrocytes in weight bearing regions of human articular cartilage produce a greater quantity of GAG than those located in non-weight bearing areas. We conclude that mechanical loading is essential in maintaining the biochemical composition of human articular cartilage.


SP Krishnan JA Skinner J Jagiello RWJ Carrington AM Flanagan TWR Briggs G Bentley

Aims: To investigate

the influence of histology on durability of cartilage repair following collagen-covered autologous chon-drocyte implantation (ACI-C) in the knee.

the relationship between macroscopic grading and durability of cartilage repair; and

the relationship between macroscopic appearance and histology of repair tissue.

Patients and methods: The modified Cincinnati scores (MCRS) of eighty-six patients were evaluated prospectively at one year and at the latest follow-up (mean follow-up = 4.7yrs. Range = 4 to 7 years). Biopsies of their cartilage repair site were stained with Haema-toxylin and Eosin and some with Safranin O and the neo-cartilage was graded as hyaline-like (n=32), mixed fibro-hyaline (n=19) and fibro-cartilagenous tissue (n=35). Macroscopic grading of the repair tissue using the international cartilage repair society grading system (ICRS) was available for fifty-six patients in this study cohort. Statistical analyses were performed to investigate the significance of histology and ICRS grading on MCRS at 1 year and at the latest follow-up.

Results: The MCRS of all three histology groups were comparable at one year evaluation (p=0.34). However, their clinical scores at the latest follow-up showed a significantly superior result for those with hyaline-like repair tissue when compared to those with mixed fibro-hyaline and fibro-cartilagenous repair (p=0.05).

There was no correlation between the ICRS grading and MCRS either at one year (p=0.12) or at the latest follow-up (p=0.16). Also, the ICRS grading of the repair tissue did not correlate with its histological type (p=0.12).

Conclusion: We conclude that any form of cartilage repair gives good clinical outcome at one year. At four years and beyond, hyaline-like repair tissue produces a more favourable clinical outcome. Macroscopic evaluation using the ICRS grading system does not reflect the clinical outcome or its durability or the histological type of repair tissue.


CM Thomas C Whittles C Fuller M Sharif

Apoptosis of articular chondrocytes may play an important role in the pathogenesis of osteoarthritis (OA). The aim of this study was to investigate the incidence of chondrocyte apoptosis in equine articular cartilage (AC) specimens and examine the relationship between the process of cell death and the degree of cartilage degradation.

The study comprised 2 populations of equine cartilage taken from the left forelimb. Population 1 (n=10) consisted of full depth cartilage from weight-bearing regions of equine metacarpophalangeal (MCP), proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints. Population 2 (n=9) comprised cartilage from 6 different regions of the MCP joint: dorsomedial, dorsolateral, centromedial, centrolateral, palmarome-dial and palmarolateral areas. Cartilage from each horse for each of the joints and joint regions was not always available. Seven micrometre cryostat sections were obtained. Haematoxylin and Eosin with Safranin-O stained sections were used to score structural differences between samples for features of cartilage pathology using a ‘modified’ Mankin scoring system. Two methods were used to quantify apoptotic chondrocytes: a direct method in which chondrocytes were assessed for morphological features of apoptosis using a light microscope and an immunohistochemical staining technique to detect the expression of active caspase-3 using a commercially available monoclonal antibody.

Apoptosis assessed by the direct method did not show any association with increasing severity of OA (r=0.11, p=0.7205). Overall there was a positive correlation between caspase-3 expression and cartilage damage (r= 0.44, p=0.0043). Caspase-3 expression was found to increase linearly with increasing severity of OA in the superficial, middle and deep zones of AC (r=0.36, p=0.0198; r=0.49, p=0.0011 and r=0.37, p=0.0237 respectively). Moreover, caspase-3 expression was higher in the superficial and middle zones than in the deep zone (p< 0.001). In the superficial, middle and deep zones the expression of caspase-3 was higher in the MCP joint than the PIP joint (p< 0.05, p< 0.01 and p< 0.05 respectively).

The significant positive correlation between disease severity and chondrocyte apoptosis, suggests that this process plays an important role in the pathogenesis of OA. The differences in the extent of apoptosis observed in different joints could be explained by the biomechanical environment of the joints.


SM McDonnell R Benson P Hulley N Athanasou AJ Carr AJ Price

Antero-medial osteoarthritis of the knee displays a well recognised pattern of cartilage damage on the medial tibial plateau. Anteriorly there is a full thickness cartilage defect, with transition to a partial thickness defect, becoming full thickness in the posterior third of the plateau. The retained posterior cartilage is macroscopically normal, but no previous study has assessed its histo-logical features. This study characterises the histological changes, to examine if antero-medial OA of the knee represents a model of progressive osteoarthritic cartilage damage.

Five unicompartmental resection specimens of patients with idiopathic single compartment antero-medial osteoarthritis were assessed. The samples were stained with H& E and Saffinin-O stains and reviewed using the Mankin system, an established method for scoring osteoarthritic changes in cartilage (range 0 [normal] to 14 [grossly osteoarthritic]) Digital images of the histology were reviewed by two observers to exclude inter and intra observer error. Each specimen was assessed at 4 interval points (A,B,C,D) along the A-P axis starting from the most posterior aspect of the exposed bone to the area of macroscopically normal cartilage. Three repeat measurements were taken from the macroscopically normal region (D1,D2,D3). The scores were compared to historical age matched controls of non-osteoarthritic cartilage, where a Mankin grade of < 3 suggests normal cartilage.

From anterior to posterior the H& E staining showed a consistent decrease in structural integrity and cellularity of the cartilage, matched by a qualitative decrease in GAG content (Saffinin-O staining). Mean Mankin scores showed a progressive decrease in score; A = 14.0 (95% CI 0), B = 5.8 (95%CI 2.4), C = 4.4 (95%CI 2.5), D = 1.0 (95%CI 0.9) {p=0.04 ANOVA}. Repeated measurements at the macroscopically normal area showed the Mankin grade was maintained; D1= 1.0 (95%CI 0.9), D2 = 0.6 (95%CI 0.5), D3 = 0.6 (95%CI 0.6).

The results show that the retained posterior cartilage in antero-medial arthritis has a consistently normal Mankin grade. We suggest the defect represents a model of progressive cartilage damage from near normal (posterior) to the grossly osteoarthritic state (anterior).


L Mills B Noble S Fenwick H Simpson

Introduction: Atrophic nonunion is a well recognised complication of long bone fractures. Clinical trials show that BMP-2 accelerates healing and reduces nonunion in open tibial fractures. We are interested in a natural small molecule that has been previously demonstrated to stimulate angiogenesis in vivo. Our aim is to assess the two treatments in the prevention of nonunion. The small animal model we used is a non-critical size defect of the tibia deprived it of its blood supply by surgical stripping of the periosteum and curetting of the local endosteum thus closely reflecting the clinical situation. The outcomes were measured by radiographic assessment and histology.

Methods: Wistar rats were treated with either the angiogenic molecule (0.1% or 0.003%), BMP-2 or vehicle alone (PBS) soaked in a type I collagen sponge. All animals underwent a 2mm osteotomy, stripping of the periosteum and endosteum proximally and distally for the length of the diameter of the tibia. Fluorescent markers were injected at 2 weekly intervals. The rats were sacrificed at 8 weeks. Both tibiae were disarticulated; fixator and soft tissues were removed and AP and lateral X-rays were taken. Subjective assessment of the healing on X-ray was carried out in two ways; using a radiographic scoring system and by grey scale analysis. The samples were embedded, sectioned and stained for new bone formation.

Results: Bridging or potential to bridge was seen in a number of animals on x-ray. Bridging or potential to bridge was judged to be present in 72.22% of the BMP-2 group and 66.67% of the high dose group compared to 22.22% of the control group. Histological analysis is being performed to confirm these findings.

Discussion: Atrophic nonunion is a serious clinical complication, unfortunately BMP-2 is a highly costly treatment option and therefore alternative molecular therapies are much sought after. We describe here an angiogenic molecule has some potential in preventing formation of nonunion.


L Gardner G Varbiro GT Williams J Trividi S Roberts

Cells of the intervertebral disc exist in an unusual environment compared to those of other tissues. Within the disc there are low levels of nutrients available, low oxygen levels and it is an acidic environment due to high lactate levels. Apoptosis (programmed or controlled cell death) has been reported in intervertebral discs, as well as necrosis (uncontrolled cell death). This study has focused on examining the sensitivity of nucleus pulpo-sus (NP) cells to several stimuli, in comparison to two other cells types.

Ultra violet (UV) irradiation, serum starvation (with no foetal calf serum) and treatment with 2mM hydrogen peroxide were used to induce apoptosis in cultured bovine NP cells, HeLa (cancer cell line) and 293T cells (human embryo kidney derived) cells. Apoptosis was identified by nuclear morphology following staining with fluorescent Hoechst 33342 dye and propidium iodide; the incidence was measured at 24, 48 and 72 hours. Untreated controls were used for each treatment and at each time point.

The incidence of apoptosis increased with time for all treatments. After 72 hours, UV treatment produced the highest levels of apoptosis with levels of apoptosis occurring in the order of HeLa (94%) > NP cells (29%) > 293T cells (15%). Treatment with hydrogen peroxide and serum starvation induced apoptosis at lower levels in all three cell types (maximum of 30%). Serum starvation induced apoptosis in only 10% of NP cells at 72 hours, compared to 20% in HeLa cells. None of the controls contained apoptotic cells.

NP cells are stimulated to apoptose in response to UV irradiation, hydrogen peroxide and serum starvation. However, levels of apoptosis are much lower after UV treatment in comparison to HeLa cells (3 times lower), suggesting that they may have a protective mechanism to this apoptotic stimulus, compared to HeLa cells. The low levels of apoptosis observed in NP cells with serum starvation may be due to the low nutrient environment that they exist in normally.


RM McCann G Colleary C Geddis GR Dickson D Marsh

Background & Objectives: The objective of this study was to develop a rat model of fracture repair. Fixation of experimental fractures is generally internal {Kirschner wire/intramedullary (IM) nail} or external (single/double plane devices). Internal fixation using the IM-fixated model of a standard closed fracture is well described in rats. However, nail insertion can disrupt fracture site morphology and limit x-ray analysis. We planned to create an externally fixated femoral model, to optimise our outcome measures and facilitate the further investigation of bone healing within the department.

Methods: A simple four pin unilateral external fixator was designed and constructed from four stainless steel pins, secured to a stainless steel plate with nuts. Forty-one female Sprague-Dawley rats, (12–18wks), were used. Following anaesthesia the right femur was exposed and a mid-femoral osteotomy made prior to fixator application. Post-operative x-rays were taken to confirm reduction. Animals were assigned to groups for biomechanical strength testing (BST) or histology. Fifteen animals (fractured and contralateral limbs) were sacrificed at 4, 6 or 8 weeks for BST (four-point bending). Maximum load to failure was recorded and stiffness calculated from the load displacement curve obtained. Both parameters were standardised as a percentage of the contralateral limb. Twenty-five fractured limbs were used for histological analysis at day 4, and 1, 2, 4, 6 or 8 weeks.

Results: Satisfactory reduction was confirmed in all animals post operatively and no complications were noted. Histological assessment at day 4 demonstrated a predominantly lymphocytic inflammatory response within the fracture haematoma. This was replaced with endosteal and periosteal new bone between weeks 1 and 2. Bridging of the fracture gap was seen at week 6. Stiffness and load to failure increased with increasing time. There was a statistically significant improvement in the percentage stiffness (p=0.035) and load to failure (p=0.012) between 4 and 8 weeks.

Conclusion: A simple reproducible externally fixated rat model has been established and characterised by radiography, histology and four point bending. This model has since proven to be of value in the study of the role of lipid lowering and anti-inflammatory drugs as well as cell therapy on fracture repair.


B Devitt AM Byrne A Patricelli D Murray J O’Byrne PP Doran

Wear debris is a key factor in the pathophysiology of aseptic loosening of orthopaedic endoprostheses. Cobalt-chromium-molybdenum (Co-CrMo) alloys are used for metal-metal hip implants due to their enhanced wear resistance profiles. Whilst these alloys have widespread clinical application, little is known about their direct effect on osteoblast biology. To address this issue, in this study we have investigated particle-mediated inflammation, as a putative mechanism of aseptic loosening. The effects of Co2+ ions on the bone cellular milieu were assessed in vitro by profiling of classical inflammatory mediators. The inflammatory driver PGE2 was quantified and found to be increased, following osteoblast stimulation with metal ions, suggesting the initiation of a local inflammatory response to metal particle exposure. To determine the biological import of this molecular event, the role of metal ions in recruiting inflammatory cells by chemokine production was assessed. These data demonstrated significant induction of the chemokines, IL-8 and MCP-1 following both 12 and 24 hour exposure to 10ppm of Co2+. In this study, we demonstrate that Co2+ particles can rapidly induce chemotactic cytokines, IL-8 and MCP-1 early stress-responsive chemokines that function in activation and chemotaxis of monocytes, and PGE2, which stimulates bone resorption. We have shown that this induction occurs at a transcriptional level with significantly increased mRNA levels. These data lend further weight to the hypothesis that wear mediated osteolysis, is due, at least in part, to underlying chronic inflammation.


P Pollintine I Cooper HL Anderson LR Green C Cooper SA Lanham ROC Oreffo P Dolan

Introduction: Epidemiology suggests that an intrauterine nutrient restriction increases the likelihood of osteoporosis in later life, possibly due to differences in bone structure and strength. We hypothesise that, in an ovine model, early nutritional compromise reduces vertebral cancellous bone density and cortical thickness, and thereby reduces vertebral compressive strength.

Materials and methods: Lumbar spines were dissected from 8 sheep (6 male, 2 female: mean age 2.7 yrs). Spines were divided into different groups, based on the early diet of the sheep: group CC received a control diet, group IU received low protein in utero, and group PN received low protein both in utero and postnatally. Fifteen motion segments (consisting of two vertebrae and the intervening disc and ligaments) were prepared from the spines, and compressed to failure using a hydraulically-controlled materials testing machine to obtain yield strength. 1mm-thick bone slices were taken from the mid-sagittal and para-sagittal regions of each vertebral body and micro-radiographed. Digital images of the micro-radiographs were analysed to obtain the cancellous bone density in anterior and posterior regions, and the cortical thickness in the anterior, posterior, superior and inferior regions. Repeated measures ANOVA was used to test for differences in parameters at the different locations, and between the groups.

Results: The anterior cortex was 28% thinner for the IU group, and 23% thinner for the PN group compared to controls (both p< 0.001). In the PN group, the superior cortex was also 18% thinner than controls (p< 0.02). There was no significant difference between cancellous bone density in either region. Yield strength was 16% lower in the IU group compared to controls, but this did not reach significance.

Discussion: In the nutritionally compromised groups, cortical thickness was lower in regions of the vertebral body where fractures often occur in elderly people. However, the reduction in cortical thickness is not accompanied by a significant reduction in compressive strength in the sheep model. These findings suggest that the well-maintained cancellous bone protects the vertebra from fracture.


XC Wei XD LU G Gao

The repair of cartilage defects remains a significant clinical challenge. The use of mesenchymal stem cells for cell-based tissue-engineering strategies represents a promising alternative for the repair of the defects. In this study, we investigated the TGF-bate1 dose and cellular density-dependent effect on chondrogenic differentation of human bone marrow-derived mesenchymal stem cells (MSCs) cultured in alginate beads in vitro.

Methods A volume of 6 ml bone marrow was collected from six volunteer donors respectively. MSCs were cultured in different cellular density (1×104, 1×105, 1×106 and 5×106/ml) and treated with different doses of TGF-beta1 (0, 1, 10, 50 and 100 ng/ml). Immunohistochem-istry and in situ hybridization were applied to detect the expression of collagen type II and assay proteoglycan in different time internal.

Results 95% cellss were alive after density gradient centrifugation. BMSCs had a similar spindle-like morphology. Type II collagen and proteoglycan were showed positive staining in the 10 ng/ml TGF-beta1 group, weakly positive in the 50 ng/ml and 100 ng/ml group, negative in the 0 ng/ml and 1 ng/ml group. With time, the proteoglycan quantity increased. All cell density groups except 1×104/ml showed positive expression of collagen type II and proteoglycan synthesis, and better staining with increase of cellular density. Proteoglycan synthesis did not increased until the fifth weeks.

Conclusions The chondrogenesis differentiation of human MSCs is dose-dependent. 10ng/ml TGF-beta1 is a suitable concentration for such inducing. The cellular density is also important for the differentiation of MSCs. Too small density is ineffective. The more cells, the better differentiation. And the time of in vitro culture should not be longer than 4 weeks


NS Khan SN Racey JL Tremoleda BJ Tye J McWhir BS Noble AHWR Simpson

Aim: To investigate the directed chondrogenic differentiation of human embryonic and adult stem cells in 3D alginate bead culture.

Introduction: Cartilage possesses limited self-renewal potential and current repair of damage due to trauma or disease involves removal of non-load bearing chon-drocytes from a healthy part of the joint, expansion of chondrocytes and subsequent surgery to replace damaged, load-bearing cartilage. We investigated the potential of human embryonic and adult stem cells as an alternative cell source for cartilage repair.

Experimental design: Human embryonic stem cells (hESC) and human adult marrow stromal cells (hMSCs) cells were cultured in alginate in a 3D bead format in control or chondrogenic media over a 21day period. Cells were subsequently released from their matrix for gene expression analysis or fixed within alginate beads and crytostat sections prepared for immunostaining and histology.

Cell types used: H9 human embryonic stem cells, bone-marrow derived hMSCs and HEK293 (human embryonic kidney epithelium cell line, used as a negative control).

Data: H9 and hMSC cells cultured in alginate beads bathed in control media have a denser matrix with no lacunae-like structures compared to those cultured in the presence of chondrogenic media. The presence of chondrogenic media results in a matrix containing cells within lacunae-like structures very similar to those seen in human cartilage. In contrast, HEK293 cells formed large highly cellular clusters which had clearly undergone significant proliferation. As both H9 and HEK293 cells are highly proliferative the reduction in the proliferative potential of the chondrogenic H9 derived cells is consistent with entry into a stable terminally differentiated state.

Immunostaining demonstrated that hMSCs and H9 cells express cartilage specific Collagen II and Collagen X.

Conclusion: 3D culture of adult hMSCs and hESC (H9) in alginate beads has resulted in stable directed differentiation down the chondrogenic lineage. These data point towards the future use of these human cell sources in cartilage repair.


SF Hughes BD Hendricks SS Bastawrous DR Edwards JFS Middleton

Leucocytes are white blood cells that help the body fight against bacteria, viruses and tumour cells. However, the activity of leucocytes has been implicated in other clinically important inflammatory conditions such as ischaemic heart disease, stroke, and during cardio-aortic and orthopaedic surgery.

The main objectives of this study was to optimise methods for the isolation of leucocyte subpopulations (neutrophils and monocytes), and to assess in vitro the effects of PMA and fMLP on markers of leucocyte adhesion (CD11b, CD62L) and activation (intracellular hydrogen peroxide) (n=10). Leucocyte subpopulations were labelled by incubation with fluorescein isothiocya-nate (FITC) conjugated anti-human CD11b and CD62L antibodies. The cell surface expression of these labelled adhesion molecules were measured by flow cytometry. Intracellular production of hydrogen peroxide by neutrophils and monocytes was measured by flow cytometry, using the fluorochrome dichloroflurorescin diacetate (DCFH-DA). These were visualised by Immunofluorescence microscopy.

During this study, methods of isolating leucocyte subpopulations from whole blood were optimised. This ensured that these cells were isolated with consistently high yields, purity and with no changes in cellular function. Following incubation with PMA and fMLP, neutrophils and monocytes displayed an increase in CD11b cell surface expression; a decrease in CD62L cell surface expression; and increased leucocyte activation. Leucocyte activation was represented by the intracellular production of hydrogen peroxide.

In conclusion this study confirms that both PMA and fMLP have an intrinsic effect on markers of leucocyte function. These findings are in agreement with previous studies performed.


AJ Martin V Mann AHRW Simpson BS Noble

Bone substitutes have emerged as a promising alternative in surgeries requiring bone grafting, with a large array of materials available for today’s surgeon. Unfortunately, there is currently no definitive method for comparing the potential bone-healing potential of these different materials. We have developed a novel technique for assessing the osteogenic capacity of different bone substitutes in a mechanically-stimulating perfusion bioreactor.

The Zetos(TM) bioreactor system consists of individual flow chambers connected to a low-flow perfusion pump, which recirculates media through samples. The Zetos can be programmed to apply a controlled stress or a controlled strain to each individual sample inside the flow chamber. Since bone formation has been shown to be optimal with short doses of high amplitude strains, test samples were subjected to daily loading corresponding to physiological strain experienced during a jumping exercise (maximum 3000 microStrain).

Three substitute materials representing the range of materials available clinically were tested in the Zetos system; these included collagen, calcium phosphate, and a synthetic polymer. Primary human osteoblasts were seeded onto the substitutes, which were then placed inside the Zetos system and maintained under load or non-load conditions for 14 days. No supplementary osteogenic factors were provided to the cells. The degree of bone formation in the samples was assessed using Von Kossa staining and quantified in terms of the area of new mineral relative to the surface area of the substitute.

No mineralisation was detected in the non-loaded samples. However, in the loaded samples, mineralisa-tion was detected in some of the substitutes. The degree of mineralisation depended on the material: in collagen, an average of 0.22 mm2/mm2 was mineralised; in calcium phosphate, mineralisation averaged 0.0013 mm2/ mm2; but in the loaded polymer samples, no mineralisation was detected.

This indicates that mechanical loading is a sufficient stimulus for bone formation in some materials, even in the absence of other known osteogenic factors. Further, commercial substitutes differ in their ability to support bone formation under conditions of physiological loading. Further development of this technique could allow it to be used as a screening tool for predicting the efficacy of commercial products.


DH Park SP Krishnan JA Skinner RWJ Carrington AM Flanagan TWR Briggs G Bentley

Purpose: We report on minimum 2 year follow-up results of 71 patients randomised to autologous chon-drocyte implantation (ACI) using porcine-derived collagen membrane as a cover (ACI-C) and matrix-induced autologous chondrocyte implantation (MACI) for the treatment of osteochondral defects of the knee.

Introduction: ACI is used widely as a treatment for symptomatic chondral and osteochondral defects of the knee. Variations of the original periosteum-cover technique include the use of porcine-derived type I/type III collagen as a cover (ACI-C) and matrix-induced autolo-gous chondrocyte implantation (MACI) using a collagen bilayer seeded with chondrocytes.

Results: 71 patients with a mean age of 33 years (15–48) were randomised to undergo either an ACI-C or a MACI. 37 had ACI-C and 34 MACI. The mean size of the defect was 5.0cm2. Mean duration of symptoms was 104.4 months (9–456). Mean follow-up was 33.5 months (24–45). Functional assessment using the modified Cincinnati knee score, the Bentley functional rating score and the visual analogue score was carried out. Assessment using the modified Cincinnati knee score showed a good to excellent result in 57.1% of patients followed up at 2 years, and 65.2% at 3 years in the ACI-C group; and 63.6% of patients at 2 years, and 64% at 3 years in the MACI group. Arthroscopic assessments showed a good to excellent International Cartilage Repair Society score in 81.8% of ACI-C grafts (22 patients) and 50% of MACI grafts (6 patients). Fisher’s exact test showed a p value of p=0.35 (not statistically significant). Hyaline-like cartilage or hyaline-like cartilage with fibrocartilage was found in biopsies of 56.3% of the ACI-C grafts (9 out of 16 patients) and 30% of the MACI grafts (3 out of 10 patients) after 2 years. Fisher’s exact test showed a p value of p=0.25 (not statistically significant).

Conclusion: At this stage of the trial we conclude that the clinical, arthroscopic and histological outcomes are comparable for both ACI-C and MACI.


DAM Amer E Jones X Yang

A combination of stem cell therapy and tissue engineering is emerging as one of the most promising approaches for skeletal tissue repair and regeneration. Osteoinduction of human bone marrow mesenchymal stem cells (MSCs) is initiated through local signals or growth factors, of which the bone morphogenetic proteins (BMPs) are the best characterised. Cytomodulin-1 (CM-1), a synthetic heptapeptide with functional similarity to members of the TGF-B super family, has been classified as a novel growth factor associated with osteoinduction of MSCs. However, the effects of CM-1 on human bone MSCs are still unclear. The aim of this study was to determine any effects for CM-1 and its scrambled control (CM-1 SCRAM) on the proliferation and differentiation of human bone marrow MSCs along the osteogenic lineage.

Primary human bone marrow MSCs were cultured in the presence of CM-1 and CM-1 SCRAM at a range of concentrations (10-8M – 10-6M) in vitro for up to three weeks. 100 ng/mL of recombinant human BMP-2 (rhBMP-2) was used as a positive control. At the end of the culture period, histological and biochemical assays were carried out on the cultures.

Biochemical assays revealed that 10-7M of CM-1 significantly stimulated alkaline phosphatase specific activity compared with the negative control group (P< 0.05) in a similar way to the rhBMP-2 positive control group. These data were supported by an observed increase in positive alkaline phosphatase staining in the 10-7M of CM-1 and rhBMP-2 treated cells. However, total DNA content was not significantly different between any of the groups.

This study indicated the potential of using CM-1 as an osteogenic growth factor for skeletal tissue regeneration which may provide an alternative approach to meet the major clinical need in orthopaedics and craniofacial surgery.

* Cytomodulin-1 and the scrambled control were genuine gifts from Professor (emeritus) Rajendra S. Bhatnagar at the Department of Bioengineering, University California Berkley, USA.


M Bhattacharyya B Gerber

To illustrate our clinical experience of using a complete biological method of fixation in ACL surgery and correlate the histology at the graft and the host bone interface performed in an animal experiment.

Materials: 18 male patients of mean age were 31.2 years (range 18 to 50 years) were operated on. The autogenous graft prepared from lateral part of the quadriceps aponeurosis, part of the patella and ligament leaving distal tibial attachment, passed through the trans-osseous tunnel so that bony part of the graft stay within the femoral tunnel, remaining part was sutured with the iliotibial tract.

Patients began immediate knee exercises with continous-passive-motion devices in the recovery room. With 100 degrees of knee motion, they allowed to bear full weight on the operatively treated limb with knee in a brace in extension

Results: 3 patients had superficial wound infection and 2 had haemarthrosis. None had any laxity or flexion contracture, mean flexion arc was135 (130–145) degree.

Conclusion: Histology of the bone graft and host tunnel confirms full incorporation of the graft in experimental animals performed by our senior author. The procedure of biologic fixation method in ACL reconstruction surgery to preserve the biological integrity of the patellar ligament distally in the tibial end may avoid early failure in fixation method. The biological integration producing a bone block in the femoral tunnel may enable clinician to start early rehabilitation program.


DH Park PK Jaiswal W Al-Hakim OM Stokes J Jagiello RC Pollock JA Skinner SR Cannon TWR Briggs

Purpose: We report a series of 58 patients with metastatic bone disease treated with resection and endoprosthetic reconstruction over a 5 year period at our institution.

Introduction: The recent advances in adjuvant and neo-adjuvant therapy in cancer treatment has resulted in improved prognosis of patients with bone metastases. Most patients who have an actual or impending pathological fracture should have operative stabilisation or reconstruction. According to BOA guidelines patients should undergo a single procedure which allows early full weight bearing and lasts the expected lifespan of the patient. The use of modern modular endoprostheses allows these criteria to be met.

Methods and Results: We retrospectively identified all patients diagnosed with metastatic disease to bone between 1999 to 2003. 171 patients were diagnosed with bone metastases. Metastatic breast and renal cancer accounted for 47% of the lesions. 58 patients with bone metastasis to the appendicular skeleton had an endo-prosthetic reconstruction. There were 28 males and 30 females. 11 patients had lesions in the upper extremity and 47 patients had lesions in the lower extremity. Mean age at presentation was 62 years (24 to 88 years). 19 patients are still alive, 34 patients had died and 5 were lost to follow-up. Patients died of disease at a mean of 22 months (2 to 51 months) from surgery. Mean follow-up was 55 months (24 to 78 months). There were 5 wound infections, 1 aseptic loosening, 3 dislocations, 1 subluxation and 1 prosthesis rotated requiring open repositioning. Patients were followed up and evaluated using the Musculoskeletal Society Tumour Score (MSTS) and the Toronto Extremity Salvage Score. The mean MSTS score was 73% (57 to 90%) and TESS was 71% (84 to 95%).

Conclusions: We conclude that endoprosthetic replacement for the treatment of bone metastases in selected cases achieves the aims of restoring function, allowing early weight bearing and alleviating pain. The complication rate is low.


OM Stokes W Al-Hakim D Park P Unwin GW Blunn R Pollock JA Skinner SR Cannon TWR Briggs

Introduction: Since 1975, 6 types of extendable endo-prostheses have been developed at Biomedical Engineering, UCL, and Stanmore Implants Worldwide in conjunction with the surgeons at this centre.

Aims: To establish whether developments in design have had the desired effect of improving both implant survivorship and functional outcome.

Methods: This was a retrospective study using case notes, hospital databases and a radiological review, combined with contemporary functional outcome assessments (MSTS, TESS, SF36).

Results: 161 consecutive prostheses in 138 paediatric patients, between the years of 1983 – 2005, were implanted for primary bone tumours. Mean age was 10.3 (3 – 18), 81 were males and 57 females. There were 136 primary procedures and 25 revisions.

6 prostheses that used ball bearings to achieve length (designed in 1981) were implanted, 3 (50 %) were revised due to mechanical failure.

19 prostheses that utilised external C-washes (1998) to achieve length were implanted, 6 (32 %) were revised, half of these for mechanical failure.

Of the 98 minimally invasive prostheses (1992) that utilized an Allan key and screw-jack mechanism to lengthen, 14 (14 %) were revised, half of these for infection.

17 non-invasive extendable endoprostheses (2001) that are lengthened by electromagnetic coupling have been implanted so far. There has only been 1 (6 %) revision. This was due to full extension being reached.

Conclusions: Design improvements in growing endoprostheses since 1983 have led to improved survivorship. Initially this led to a reduction in mechanical failure and latterly to a reduction in infection, as indications for revision.

Key Words: Bone tumour, children, endoprosthesis, survivorship.


S Kalra A Abudu H Murata R Grimer R Tillman S Carter

Background: Limb preserving surgery in patients with tumours involving the whole femur present a formidable challenge.

Results: We present our experience of treating such patients with total femur endoprostheses over the last 30 years (1975 to 2005). There were twenty six consecutive patients including 14 males and 12 females. Average age was 40 years (14 – 82 years) at the time of surgery. Eleven patients were still alive of which nine were free of disease at the time of review. The mean follow-up was 57 months (3 to 348). Using Kaplan Meier estimates, the long-term patient survival at 10 years was 37%. The survival of patients with primary localised tumour was 50% at 10 years.

Revision of the prostheses was necessary in two patients at 110 and 274 months after surgery because of recurrent dislocation in one and aseptic loosening of the acetabular cup and tibial stem in the other. Amputation was necessary in two patients, one due to deep infection and the other due to local recurrence. The long-term limb survival being 92% at 10 years. Nine patients who were alive with no evidence of disease were assessed for function of the salvaged limbs using the musculoskeletal tumour society (MSTS) rating system. The mean functional score was 72%.

Conclusion: We conclude that total femur endoprosthetic replacement offers an excellent method of limb reconstruction following excision of the whole femur either for primary or metastatic tumours. However, patients survival after such operation is poor due to disease related factors.


G Myers R Tillman S Carter A Abudu P Unwin R Grimer

We have investigated whether improvements in design have altered outcome for patients undergoing endoprosthetic replacement of the distal femur following tumour resection.

Survival of the implant and ‘servicing’ procedures has been documented using a prospective database and review of the implant design records and case records.

A total of 335 patients underwent a distal femoral replacement with 162 having a fixed hinge design and 173 a rotating hinge. The median age of the patients was 24 years (range 13–82yrs). With a minimum follow up of 5 years and a maximum of 30 years, 192 patients remain alive with a median follow up of 11 years. The risk of revision for any reason was 17% at 5 years, 34% at 10 years and 58% at 20 years. Aseptic loosening was the most common reason for revision in the fixed hinge knees whilst infection and stem fracture were the most common reason in the rotating hinges. The risk of revision for aseptic loosening in the fixed hinges was 32% at ten years compared with 4% for rotating hinge knees with a hydroxyapatite collar. The overall risk of revision for any reason was halved by use of the rotating hinge.

Conclusion: Improvements in design of distal femoral replacements have significantly decreased the risk of revision surgery. Infection remains a serious problem for these patients.


J M Jagiello G Y Sheshappanavar O M Stokes D G Park R Pollock J A Skinner T W R Briggs S R Cannon

Background: Advances in adjuvant and neoadjuvant therapies have rendered many tumours that previously necessitated amputation amenable to limb salvage procedures. However, a significant proportion of tumours are still treated by hindquarter amputation in an attempt to cure the patient, or to reduce the tumour load. This tends to be lengthy, mutilating and is associated with high morbidity and poor survivorship.

Aims: To review the survivorship, quality of life and functional assessment following hindquarter amputations performed in this centre in the last 10 years.

Methods: This was a retrospective study of 51 consecutive patients who had hindquarter amputations for tumours between 1996 to 2006. Available patients were evaluated using contemporary functional outcome assessments (Musculoskeletal Society Tumour Score, Toronto Extremity Salvage Score, SF36).

Results: Fifty-one patients (31 males, 20 females) had palliative(8) or curative hindquarter amputations(43) for Chondrosarcoma(18), Malignant Fibrous Histiocytoma(6), Osteosarcoma(4) and other sarcoma sub-types(23). The mean age was 50.7 years (range 24–78). The mean duration of symptoms until referral was 5.2 months, the mean time from referral to tissue diagnosis was 16.2 days (range 2–80) and the time from confirmed histological diagnosis to surgery was 39.2 days (range 2–190) on average. Significant complications included phantom limb pain(15), wound problems(24), urinary problems(6), cardiopulmonary events(5) and erectile dysfunction(3). 33 of the 51 patients have passed away, with a mean survival postoperatively of 10.7 months (range 2–43), with carcinomatosis the main cause of death. The mean cumulative survival following hindquarter amputation in this hospital is 17.3 months.

Conclusions: Patients with no metastasis and clear margins at amputation had a better cumulative survival rate. Therefore the decision to proceed for hindquarter amputation to achieve a curative resection is justified but has to be weighed up against the associated significant complications, morbidity and functional deterioration.


PK Jaiswal A Gupta O Strokes R Pollock SR Cannon TWR Briggs G Blunn

Aim: To study the remodelling of cortical bone around the passive growing component of an expandable endoprosthesis.

Introduction: When inserting the passive component of an expandable prosthesis a polyethylene sleeve is commonly used. The sleeve migrates towards the lateral cortex and causes a cortical reaction and hence the use of the sleeve has been discarded recently. This study quantifies the amount of cortical reaction and degree of cortical drift in patients that had sleeves and those that did not.

Material And Methods: We reviewed X-rays and case notes of all patients that had an expandable endoprosthesis in a 20 year period. The thickness of medial and lateral cortices of the tibial diaphysis was measured at 6 months and on the last follow up radiograph. The distance from the edge of the sleeve (or prosthesis) from the cortical edge was also compared. Retrieved components also had their histology reviewed.

Results: The sleeve shifted laterally on average by 2mm (range 0.5 – 3mm) and touched the cortex. This was associated with an increase in lateral cortical thickness by 2.27mm (range 1 – 3mm). When the sleeve was used the prosthesis was inserted in the mid-line. When the sleeve was not used the tibial component tended to be inserted in valgus.

Conclusions: The presence of a sleeve is associated with a cortical reaction and the sleeve tends to migrate laterally. The clinical implications of this and the evolution of the design will be discussed in the meeting.


DH Park RC Pollock B Seddon OM Stokes JA Skinner TWR Briggs SR Cannon

Purpose: We report a series of patients with malignant tumours of the pelvis that had a tissue expander inserted in the pelvis to facilitate radical radiotherapy, and report functional outcomes following treatment.

Introduction: Surgery for malignant tumours affecting the pelvis is challenging. Some tumours are suitable for internal hemipelvectomy and reconstruction, some require hindquarter amputation and some are inoperable. Overall prognosis is poor with high morbidity and mortality rates. There may be a place for alternative treatment with the insertion of pelvic spacers to facilitate radical radiotherapy. This is indicated in patients who have an inoperable tumour, who decline amputation, or who had an internal hemipelvectomy with close margins and high risk of local recurrence.

Methods & Results: We performed a retrospective review of all patients who presented with a malignant tumour of the pelvis and who underwent an insertion of a pelvic spacer followed by local high dose radiotherapy. Available patients were followed up and evaluated using the Musculoskeletal Society Tumour Score (MSTS) and the Toronto Extremity Salvage Score (TESS). There were ten patients; 5 had Ewing’s sarcoma, 3 had osteosarcoma, 1 had spindle cell sarcoma and 1 had alveolar soft part sarcoma. 4 patients had metastases on presentation. The average age was 30 years (14 to 56 years), and average follow-up was 15 months (12 to 24 months). 4 patients died and 6 are still alive. There were no surgical complications. The average length of hospital stay was 6 days (2 to 10 days). Patients averaged an MSTS score of 63% and a TESS of 67%.

Conclusion: Radical radiotherapy after spacer insertion offers an alternative to morbid surgery and is associated with good functional outcomes.


AG Stamatoukou RJ Grimer SR Carter RM Tillman AA Abudu

Aim: To investigate the outcome of prosthetic pelvic replacements., analyzing complications and suggesting ways of avoiding these

Method: We reviewed the records of all 52 patients undergoing custom made hemipelvic replacement of the pelvis at our centre over the past 30 years.

Results: The mean age of the patients was 40 (range 13 to 75) and the most common diagnosis was chondrosarcoma followed by Ewing’s sarcoma. 4 patients had metastases at the time if diagnosis. All tumours involved the acetabulum (P2) and 9 had a significant extension up into the ilium with 28 involving the pubis. There was a very high incidence of complications – local recurrence arose in 40% and infection in 32% at 5rs, there was a 10% risk of amputation (all for local recurrence). The overall survival of the patients was 69% at 5yrs and 59% at 10 yrs and the survival of the prosthesis without a major complication (infection or local recurrence) was only 40% at 5 and 10 yrs. Local recurrence was related to effectiveness of chemotherapy and margins whilst infection was increased by tumours involving the pubic area.

Discussion: Although a successful hemipelvic replacement can produce a good functional outcome, the incidence of complications is very high. Steps to reduce these risks should be carefully considered including the use of wider margins and the use of silver coated prostheses as well as greater use of local or free flaps in selected cases.


P K Jaiswal A Gupta W Al-Hakim R Pollock G Blunn S R Cannon T W R Briggs

Aims: The main purpose of this study was to evaluate hemiplevis replacements in patients with periacetabular tumours in terms of the functional results and implant survivorship of the prosthesis. The second aim was to evaluate the complications and how they might be prevented in the future.

Methods: Case notes, hospital databases and radiographs were reviewed in 51 patients treated in a 16 year period with a custom made hemipelvis replacement (Stanmore Implants Worldwide). There were 13 deaths and 4 were lost to follow up. Of the remaining 34 patients there were 18 males and 16 females with a mean age of 48.6 (range 14 – 71).

Results: At a mean follow-up of 78 months (range 7 – 204), 70% of patients were still alive and the most common diagnosis was chondrosarcoma (17 cases). There were 2 cases of prosthesis failure and 22 of the 34 patients had one or more complications (12 cases of infection (8 deep and 4 superficial), 4 nerve palsies, 2 dislocations and 7 others). 13 patients had to have a second operation. The mean MSTS score was 63.8% and the TESS score was 59.8%

Conclusion: Infection was the most common complication and was the most significant reason for reoperation. This method of reconstruction is associated with a high morbidity rate and should be performed only at specialist centres, but the functional and oncological outcomes are satisfactory.


J. Paniker S.N. Khan V.V. Killampalli A.J. Stirling

Purpose: We report our surgical management of a series of primary and metastatic tumours of the lumbosacral junction, highlighting different methods of fixation, outcome and complications.

Method: Seven patients with primary and four with secondary tumours involving the lumbosacral junction underwent surgery. After tumour resection, iliolumbar fixation was performed in all but one case, using Galveston rods (4) or iliac screws (6). All constructs were attached proximally with pedicle screws. Cross links were used in all instrumented cases and autologous and allogenic bone graft applied.

Results: There were no perioperative deaths. Mean operating time was 7.3 hours (range 3–18) and there was extensive blood loss (mean transfusion requirement 7.5 units, range 0–20). We estimate a transfusion requirement of approximately one unit per hour operating time. However, we noted no complications attributable to either blood loss or transfusions.

Ambulation improved in 5, was unchanged in 5 and deteriorated in one. Neurological status deteriorated in 4 and remained static in the others. However in all but one case the neurological deficit was defined by the nature of proposed surgery. Mean survival from surgery for patients with metastatic disease was 9.5 months (3–18). At mean follow up of 10 months (1–19 months), all patients with primary tumours were still alive without evidence tumour recurrence.

Extralesional excision, and therefore potentially curative surgery, was achieved in 4 cases where this was the primary goal of surgery (osteosarcoma, osteoblastoma, chordoma, embryonic rhabdomyosarcoma). There were no cases of metalwork failure. One patient has undergone revision surgery for pseudathrosis.

Conclusion: Sacral resection and iliolumbar reconstruction is a feasible treatment option in selected patients, offering potential cure. The fixation methods used by the authors restored lumbosacral stability, sufficient for pain relief and preserving ambulation and usually the predicted level of neurological function.


P Lakshmanan S Mitchell G Hide S Murray C Gerrand

Introduction and aims: Despite advances in local therapy, there is an ongoing risk of local recurrence after treatment for soft tissue sarcoma. Early detection of local recurrence with MRI scanning may improve outcomes for patients. The purpose of this retrospective study was to evaluate the usefulness of routine postoperative MRI scans in diagnosing clinically occult local recurrence after surgery for trunk and extremity soft tissue sarcomas.

Material and Methods: We reviewed the clinical and radiology records of all patients who underwent surgery for trunk or extremity soft tissue sarcoma in our service with the potential for 3 years of follow up. We looked at the number of postoperative MRI scans performed, the indications for the scans (routine or clinical suspicion of recurrence) and the scan results.

Results: Between 1998 and 2003, 151 patients met the inclusion criteria. The mean age was 59 (17 – 94) years. The diagnosis was liposarcoma in 37%, malignant fibrous histiocytoma in 17%, and leiomyosarcoma in 15%. Reflecting differences in practice between consultants, 79 patients had routine postoperative MRI scans, 8 patients had MRI scans following clinical suspicion of a local recurrence, and 64 patients did not have a postoperative MRI scan. Of 79 patients undergoing a total of 354 routine postoperative scans, 2 had detection of a local recurrence not suspected clinically. This represents a cost of £55,224 per recurrence detected. Of the 8 patients who underwent MRI scanning for a clinical suspicion of local recurrence, 4 had a local recurrence confirmed on scanning.

Conclusions: Most local recurrences are detected clinically. The cost of detecting local recurrence of a trunk or extremity soft tissue sarcoma by MRI scanning is high. The benefit of earlier detection over clinical examination is not known.


AC Watts KH Teoh T Evans I Beggs DE Porter

Introduction: Local recurrence of tumour following definitive treatment of bone or soft tissue sarcoma is a predictor of increased morbidity. Early detection of local recurrence may affect outcome. The role of magnetic resonance imaging (MRI) screening following definitive treatment is controversial. This study investigates the experience of one treatment centre with routine surveillance MRI following treatment of sarcoma.

Methods: Patients were identified from the records of the Regional Sarcoma Group. With Local Ethics Committee approval the casenotes, MRI and histology reports for sixty-five patients who had routine surveillance MRI scans following definitive treatment of sarcoma in a single treatment centre were reviewed. The minimum follow up period was 24 months. The primary outcome was the presence of local tumour recurrence and whether this was identified on surveillance or interval scanning.

Results: There were sixty-four patients identified with a bone or soft tissue sarcoma. All had undergone surveillance scanning biannually for the first year then annually. Six patients with Ewing’s sarcoma were excluded because they had not had surgical excision. Fifty-eight patients (59% men) with a bone or soft tissue sarcoma without metastasis between 1996 and 2003 were available for study. The median age at diagnosis was 53 years (range 6–78 years). Eighty three percent had a diagnosis of soft tissue sarcoma. Ten patients had a primary bone tumour. Fourteen patients had local recurrence (24%). Six were identified on surveillance scan, and the remaining eight required interval scans because of clinical suspicion of tumour recurrence. There were no statistical differences in gender, age, or tumour characteristics between those identified on surveillance or interval scans. All those detected on surveillance had intra-lesional or marginal resections.

Conclusions: Surveillance scanning has a role in the early detection of local recurrence of bone and soft tissue sarcoma. Whether this results improvements in prognosis require longer-term follow up studies.


A. Saithna P.B. Pynsent R.J. Grimer

Objective: Diagnostic delay is well recognised in soft tissue sarcoma (STS). The aim of this paper is to assess whether symptom duration/time to diagnosis, has any impact on patient survival and also if patient and tumour-related factors are related to the duration of symptoms prior to presentation.

Method: We performed a retrospective analysis of prospectively collected data for all patients diagnosed or treated with STS at our centre over a 20-year period. Information regard¬ing when the patients first experienced symptoms was entered into a local oncology database at their first consultant-outpatient appointment. Symptom duration was defined as time in weeks from first symptoms experienced by the patient to the time of diagnosis. Data analysis was performed using StatView and R. Risk factors were assessed by Kaplan-Meier analysis and the Cox proportional hazards model. Stat¬istical significance was determined using 95% confidence intervals where appropriate. Students t-test was used to compare categorical data.

Results: The study population comprised 1508 patients. 159 had metastatic disease at diagnosis and overall 5-year survival in this group was 14%. In view of this poor prognosis these patients were excluded from further analyses. In the remaining 1349 patients overall 5-year survival was 60%. Mean symptom duration within our study was 70.2 weeks. A Cox Proportional hazards model showed that duration of symptoms had a significant impact on survival (p=0.0037) with each additional week of symptoms reducing the monthly hazard rate by 0.2%. Patient and tumour-related factors that were significantly associated with longer symptom durations were low grade, subcutaneous tumours, and those patients with either epitheliod or synovial sarcomas. Symptom duration was not associated with tumour size or patient age/gender.

Conclusion: Patients presenting with long symptom durations/diagnostic delay, tend to have low grade disease and a more favourable outcome than patients who experience short symp¬tom durations.


W Al-Hakim PK Jaiswal D Park OM Stokes J Jagiello R Pollock JA Skinner SR Cannon TWR Briggs

Background: Extra-compartmental limb soft tissue sarcomas are notoriously difficult to treat. These tumours can exhibit macro or microscopic spread beyond the confines of normal anatomical barriers and require radical resection, often necessitating excision of bone as well as soft tissue. This will inevitably affect the patient’s functional outcome. The primary operations for these aggressive sarcomas include wide local excision of soft tissue and adjacent involved bone, radical resection with endoprosthetic reconstruction and amputation.

Methods: 85 patients who underwent such an operation between 1995 to 2000 were reviewed and categorised according to whether they received wide local excision, endoprosthesis reconstruction or amputation. Patient demographics, sarcoma details, recurrence and survival rates were identified and compared between the three groups. Functional outcomes in the 45 patients still alive were assessed using TESS and MSTS scores.

Results: Mean age was 61 years (range 8 to 92). There were 51 males and 34 females. Anatomical distribution was as follows: arm 26, leg 47, pelvis 8 and other 4. The commonest histology subtypes were MFH, leiomyosarcoma and undifferentiated soft tissue sarcoma. 17 had wide local excision of bone and soft tissue, 32 underwent endoprosthesis reconstruction and 36 underwent primary amputation. Recurrence rates were highest in the endoprosthesis group at 19%. Five year survival was worst in the amputation group at 49%. Functional outcomes were highest in the wide local excision group, and similar in the other two surgical groups.

Conclusions: Unsurprisingly survival is poorest in the primary amputee group because of the highly aggressive nature of these sarcomas, despite having the most radical treatment. The similar functional outcomes shown between endoprosthesis reconstruction and primary amputation may be influential when considering cases in which this decision is unclear and function is the main issue at stake.


Atul Malik Palaniappan Lakshmanan Luke Wigney Shona Murray Craig Gerrand

Introduction: The Two Week Waiting Time (2wwt) Standard, which requires that patients with suspected cancer referred by general practitioners should be seen within 2 weeks, was introduced in 2000. We reviewed the performance of this standard with regards to proportion of patients seen and tumour detection rates.

Methods and Results: We reviewed all the referrals sent as “two week waiters” from January 2004 to December 2005, to our bone and soft tissue sarcoma service. These referrals were evaluated for

Whether or not the referral met established referral guidelines for bone and soft tissue tumours

The proportion of patients seen within two weeks

The proportion of patients referred under the guidelines that had malignant tumours.

This was compared with the total number of referrals to the unit and their tumour detection rates.

A total of 40 patients were referred as “two week waiters” in the given time period. They were seen on an average of 8 days following the referral. Of the 40 patients, four patients had soft tissue metastasis from a primary tumour elsewhere, and six had primary malignant soft tissue tumours. 12 had a benign bone/ soft tissue tumour. 18 (45%) patients had a non neoplastic pathology (6 Muscle tear/ herniation; 4 ganglion/bursa; 2 lumps that disappeared)

During the same period a total of 515 patients were referred by other routes.

Conclusion: Only 10 of 40 patients referred under the 2-week rule had malignant tumours. The majority of referrals to our service do not fall under this rule. Significant numbers of referral under the 2wwt standard are not in line with the referral guidelines. It is our impression that the 2-week rule, whilst highlighting the need of these patients to be seen urgently may distort clinical priorities and disadvantage patients referred from other sources.


AK Bhadra O Haddo D Higgs J Pringle A Casey SR Cannon TW Briggs

Purpose: To report the importance of early diagnosis, adequate surgical margin and postoperative radiotherapy for optimum outcome and survival.

Study Design: A retrospective review of 46 sacral chordoma patients treated between 1987 and 2004.

Methods: There were 33 male and 13 female patients, with mean age of 61 years (38 to 73 year). The surgical approach depended on the level and extent of the lesion, with an anteroposterior approach used in 23 and posterior approach in 17 patients. 20 had partial sacrectomy, 17 had subtotal sacrectomy and 3 underwent total sacrectomy. 6 patients were deemed inoperable and received palliative therapy. 14 patients received radiotherapy postoperatively. The length of average follow up was 4.27 years (range 2–15.7 years).

Results: Low back pain was the most common presenting symptom (80%), and 50% patients had a palpable mass. The mean duration of symptoms prior to diagnosis was 2 years (range 1 month–10 years). Examination revealed a palpable mass in 7 both externally and on rectal examination. 10 had palpable mass on rectal examination but not externally. 2 patients presented with multiple metastases and another 2 with widespread local disease.

Excision was complete in 23 patients and incomplete in 17. Histology revealed dedifferentiation in 4. Complete excision margin was achieved in 69.6% through combined approach and 52.9% through posterior approach only. 24 patients (52%) had local recurrence. Without adjuvant radiotherapy the mean disease-free period following complete excision was 3.5 years, compared to 0.9 years following incomplete excision. Adjuvant radiotherapy extended the mean disease-free period following incomplete excision to 1.8 years.

Conclusion: An early diagnosis and careful examination is important. Wide excision remains the mainstay of treatment. If excision is incomplete radiotherapy increases the disease free period although local recurrence is inevitable. Use of combined approach increases the likelihood of complete excision.


AC +Watts DE Porter AHRW Simpson BS Noble

Introduction: In hereditary multiple exostosis (HME) the synthesis of the polysaccharide heparan sulphate (HS) is disrupted. HS-proteoglycans are low affinity receptors involved in fibroblast growth factor signaling. Activation of FGF receptor 3 (FGFr3) on mature chondrocytes leads to growth attenuation rather than stimulation. We tested the hypothesis that in HME chondrocytes with absent or reduced HS-PG synthesis there is impaired response to the FGFr3 ligand and loss of control of chondrocyte proliferation.

Materials and methods: Chondrocytes were harvested from normal growth plate (epiphyseodesis) or HME osteochondroma cartilage cap obtained as surgical discard and cultured to 70% confluence in growth media. Cells were re-plated for experimentation. Growth curves were obtained for cells over a period of 5 days. In addition proliferative responses of healthy and HME chondrocytes were determined after low serum synchronization followed by challenge with FGF 9 (10 and 100ng/ml) and incorporation of BrdU for 2hours every two hours over a twenty eight hour period. Using these techniques it is possible to describe in detail the time dependent entry of cells into S-phase of the cell cycle and compare cell lines and treatment.

Results: Significant differences were observed in the growth characteristics over a five-day period (p< 0.05). Under baseline growing conditions the chondrocytes derived from osteochondroma had a more rapid doubling time when compared with the normal growth plate chondrocyte (2.6+/− 0.6 vs 4.9+/−1.0, p< 0.05). In response to incubation with FGF-9 cells from normal growth plate have a lower peak proportion of cells entering the s-phase than with media alone (7% vs 25%). This inhibition is not observed in chondrocytes from osteochondroma.

Conclusions: It would appear that osteochondroma chondrocytes are resistant to the normal regulatory effect of FGF-9 on cell proliferation. The differential response to FGF may be responsible for the growth differences observed both in-vitro and in-vivo.


Y S Lau C L M H Gibbons N A Athanasou

Cellular mechanisms that account for tumour osteolysis associated with Ewing’s sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor κB ligand (RANKL)-dependent and RANKL-independent mechanisms. In this study our aim has been to determine whether tumour-associated macrophages (TAMs) isolated from Ewing’s sarcoma are capable of differentiating into osteoclasts and to characterise the cellular and humoral mechanisms whereby this occurs. TAMs were isolated from two Ewing’s sarcomas and cultured on both coverslips and dentine slices for up to 21 days with soluble RANKL and human macrophage colony stimulating factor (M-CSF). Osteoclast formation from TAMs (CD14+) was evidenced by the formation of tartrate–resistant acid phosphatase and vitronectin receptor-positive multinucleated cells which were capable of carrying out lacunar resorption. This osteoclast formation and resorption was inhibited by the addition of the bisphosphonate, zoledronate. Osteoclast formation was also seen when Ewing’s sarcoma-derived TAMs were cultured with TNF α in the presence of M-CSF. We also found that TC71 Ewing’s sarcoma cells were capable of independently stimulating osteoclast formation through the release of a soluble factor. These results indicate that TAMs in Ewing’s sarcoma are capable of osteoclast differentiation by both RANKL-dependent and RANKL-independent mechanisms and that Ewing’s sarcoma cells produce an osteoclastogenic factor. The role bisphosphonates may play in inhibiting osteoclast formation and osteolysis in Ewing’s sarcoma merits further investigation.


S Glyn-Jones H Pandit D Whitwell N Athanasou M Gibbons

Purpose of study: We report the results of a prospective case series of 10 patients who developed tumour-like masses following resurfacing arthroplasty

Method: Ten subjects were referred to the tumour service at the Nuffield Orthopaedic Centre with symptomatic masses around the hip, all had previously received a resurfacing arthroplasty.

We report the clinical, radiographic and histologic features of these cases.

Results: MRI and ultrasound scanning was preformed, which demonstrated masses with solid and cystic components.

Biopsy was performed and subsequent histological examination revealed a profound plasma-cell lymphocytic response associated with metal wear debris.

There were no infections in this series.

Three subjects required revision surgery.

Conclusion: Over 50,000 resurfacing arthroplasties have been implanted worldwide over the past ten years. Although the early clinical results are encouraging little is known about the long term consequences of large head metal on metal bearing surfaces. Despite this, these devices are being widely marketed and are often implanted in younger patients. Resurfacing arthroplasties are associated with high serum and urine metal ion concentrations, metal particles have also been shown to migrate along the lymphatic system. In addition, there is now evidence that high local metal ion concentrations can induce haempoietic cancers.

This study suggests that resurfacing arthoplasty can also induce a local hypersensitivity reaction in response to metal wear debris. It therefore raises new concerns regarding the long-term safety of this procedure.


J S Huntley K H Teoh K V Sokhi DE Porter

Introduction: Langerhans Cell Histiocytosis (LCH) is a tumour-like condition that runs a variable clinical course. Recent series1,2 have suggested that skeletally immature patients with a solitary bony focus (eosinophilic granuloma) have an especially good prognosis.

Aim: To compare recurrence/progression rates for Scottish patients with solitary eosinophilic granulomas, according to skeletal maturity.

Methods: Retrospective case note review of patients identified from the Scottish Bone Tumour Registry.

Results: We identified 70 cases of biopsy-proven non-spinal eosinophilic granuloma of bone. Of these, 39 were skeletally immature (< 16 years) and 31 were skeletally mature (> 16 years). Follow-up (mean 8.25 years) was either continuing or to discharge/death. On the basis of initial screening (skeletal survey/bone scan), 9 cases (13 %; 4 and 5 patients, from the paediatric and adult groups respectively) were found to have multi-focal disease. Considering those with unifocal disease:

in the immature group, 6 patients (ex 35; 17%) developed a further manifestation of the condition (2 had recurrences at same site; 2 developed a distinct focus in bone; 1 developed a distinct soft tissue lesion causing spinal cord compression; 1 developed diabetes insipidus),

in the mature group, 3 patients (ex 26; 12%) developed a distinct focus in bone but there was no other recurrence/progression.

Conclusions: For this population, these data show that the prognosis for paediatric patients with isolated eosinophilic granuloma of bone must be more guarded than that suggested by other series1,2.


KH Teoh AC Watts R Reid DE Porter

Purpose: The purpose of this study was to determine factors predictive of tumour recurrence, or refracture, following curettage as treatment for pathological fracture of the proximal humerus through a benign bone lesion.

Methods: From a cohort of patients held on a national database the factors predictive of recurrence following surgical curettage in patients with pathological fractures through benign bone tumours of the proximal humerus were examined. Thirty nine cases were identified. The diagnosis was simple bone cyst in 27 patients (69.2%), aneurysmal bone cyst in 4 patients (10.3%), (en)chondroma in 4 patients (10.3%), giant cell tumour in 2 patients (5.1%), benign chondroblastoma in 1 patient (2.6%) and fibroma in 1 patient (2.6%). The mean age was 16.5 years and 70% were male.

Results: Most of the patients presented with a history of trauma (77%). Five patients were excluded as their fractures were not treated with surgical curettage. Twenty two patients (65%) had recurrence of the lesion or re-fracture following curettage. None of the patients in whom the fracture occurred after skeletal maturity had a recurrence. Obliteration of the lesion occurred more frequently in those with greatest initial fracture displacement on pre-operative radiographs and in those with impacted fractures. The average time to union and obliteration of the lesion was 4 months (range 1 to 13 months).

Conclusions: Factors predictive of recurrence following curettage were age under 21 years, undisplaced fractures and fractures without impaction on initial radiographs. Patients with these features should be followed up until obliteration of the lesion or skeletal maturity.


A Mahendra O P Singh M Khanna P Kumar

Giant cell tumor of bone is a benign lesion that is ‘locally aggressive and potentially malignant’. The most common specific location of ‘GCT’ is about the knee (50–65%), followed by the distal radius (10–12%), sacrum (4–9%) and proximal humerus (3%–8%). The pelvis is recognized as an infrequent site of involvement accounting for as few as 2% to 3% of all giant cell tumors. Giant cell tumors often can reach an alarming size in the pelvis jeopardizing the surrounding structures.

Treatment options described in literature for pelvic giant cell tumors include radiation therapy; surgery with intralesional margin; surgery with an intralesional margin and physical adjuvants, and surgery with wide margins.

Following Type II (Periacetabular) resections the two preferred modes of reconstruction are either Saddle Prosthesis or Ilio femoral fusion. But, in patients with extensive periacetabular involvement with tumor extension into ilium the type II resection has to be combined with a Type I (Ilial) resection. This may result in insufficient ilium being available for reconstruction to consider either a iliofemoral fusion or a saddle prosthesis. In such situations we recommend Sacroiliofemoral fusion as a novel variation of iliofemoral arthrodesis.

We present two cases of GCT of pelvis with significant periacetabular involvement treated by Sacroiliofemoral fusion. A follow up at 2 years in both cases showed no recurrences, mean MSTS of 21 & TESS of 70.

This paper discusses the various treatment options for such extensive periacetbular giant cell tumors, operative technique for sacroiliofemoral fusion, outcome evaluation after 2 years by MSTS & Toronto Extremity Salvage scores.


Atul Malik Palaniappan Lakshmanan Craig Gerrand Philip Haslam

Background: Giant-cell tumour (GCT) of bone is a benign but aggressive tumour, usually treated by radical surgical curettage. Surgical treatment of GCT involving the ischium is associated with a high local recurrence rate. We describe a case in which serial arterial embolisation and bisphosphonate treatment resulted in radiological healing of the tumour. So far we have avoided surgical treatment.

Case Report: A 40-year-old lady was referred to the bone tumour unit following a fall. A plain radiograph of the pelvis revealed a lytic lesion in the ischium, extending into the posterior column of the acetabulum and associated with a pathological fracture. Biopsy confirmed a diagnosis of GCT. Given the anatomic location, the tumour was treated with serial arterial embolisation and intravenous zoledronate infusions. Follow up at one-year shows healing of the lesion, with no radiological evidence of recurrence. The patient has so far avoided surgery.

Discussion: Serial arterial embolisation has been described in the treatment of giant cell tumours in anatomical regions where surgery is likely to be associated with significant morbidity, such as the sacrum. There is a sound theoretical basis for the use of bisphosphonates in this disease; they have been shown to cause apoptosis of the osteoclast-like giant cells and interfere with osteoclast recruitment. As far as we are aware this is the first case described in which embolisation and bisphosphonate treatment appears to have led to healing and stabilisation of the lesion. The durability of this response remains uncertain.


S Bhagat D Pillai H Sharma M Naik P Amin J Pandit M.P. Shah

Objective: To analyse long term outcome of pedicled patellar implantation in treating the defect of the knee joint after the excision of giant cell tumor of distal femur.

Methods: The geometry of patella has lead to its use for condylar reconstruction following resection for giant cell tumour around knee. 15 such patients were treated at our institute and followed up for a mean period of 7.3 years. Average age at presentation was 14.8 years. All patients had plain x-rays, angiography as needed, CT scan and MRI to check integrity of articular cartilage and ACL. Size of lesion was measured on CT. Predominant lateral condyle involvement was found in 6 and medial in 9 patients. The patella was dissociated with a slip of quadriceps attached to its proximal superior-medial pole and rotated to place it horizontally in the zone of resection. Firm osteosynthesis to intact condyle and autogenous bone grafting was carried out.

Results: Grafts consolidated at a mean of 10.8 months. All joints were fairly stable and 70% had movement of 90 degrees without pain. 11 patients had excellent outcome with ability to carry on occupations involving manual labour. There were reoperations for 2 deep infections, 1 recurrence leading to arthrodesis, 1 supracondylar fracture, 2 arthrolysis and 1 valgus osteotomy. 4 patients had arthritic changes and extensor leg at 6 years follow up. No AVN changes or extensor mechanism problems occurred. Using chi square test for log rank analysis significant relationship was found between size of lesion and range of motion (P=0.03) as well as articular cartilage grading and development of arthrosis. The rate of healing was faster than other series reporting free patella grafting.

Conclusion: Patellar implantation is a suitable way to repair the defect of the knee with better immediate functional results subsequently delaying eventual prosthesis surgery.


B.C. Navadgi Sharath K. Rao

Purpose of the Study: To study the results of resection of giant cell tumour around the knee and limb salvage by distraction osteogenesis using Ilizarov construction over intramedullary nail.

Summary: The treatment of GCT has ranged from curettage and en-bloc resection. It has always been a challenge to reconstruct the resected gap especially across the joints. We have done juxta articular resection of the tumour followed by interlocking nailing across the resected gap as first stage. In the second stage simple Ilizarov construct was used for transportation of bone across the resected gap.

Results and Discussion: There were 6 male and 2 females. The mean age at presentation was 27 years. 3 lesions were in proximal tibia and 5 in the distal femur. The mean length of bone defect was 13.9 cm. With trifocal distraction the mean duration of Ilizarov external fixation was 90 days. We used colour doppler to asses the quality of regenerate during follow-ups. Mean duration of follow up was 44 months. A good quality of regenerate was seen at last follow up and all patients were fully weight bearing.

Allografts are an alternative to endoprosthetic reconstruction but high incidence of complications such as fracture, deformity and infection makes the outcome unpredictable. The treatment option of reconstructing the resected gap with endoprosthesis is limited in our Indian subcontinent set up because of limited resource and availibility. The advantage include, the method we used has given us best alternative which allowed us to fill the large resected gap without the need of massive bone grafts. The distraction from both sides of resected gap has reduced the transportation time and use of DCP plate across the docked bone has allowed us to remove the fixator earlier. The regenerate had sufficient biological strength and durability. The disadvantages include the long duration of external fixation and related problems such as pin tract infections and frustration of patients due to the long period of treatment.

Conclusion: Resection of tumour across the joint especially around the knee and recostruction by distraction osteogenesis using Ilizarov construct over the nail to fill the large gaps without using grafts is very encouraging.


S Bhatnagar H Murata H Aherns RJ Grimer SR Carter A Abudu

We reviewed the treatment and clinical outcome of 32 consecutive patients with Ewing’s sarcoma who presented with or developed pathological fracture after biopsy between 1984 and 2004. The minimum follow-up was 18 months. The mean age at diagnosis was 20 years (5 – 51). There were 18 males and 14 females. All patients were newly diagnosed and had localized disease at the time of diagnosis. 21 patients presented with pathological fracture while 11 patients developed fracture during the course of chemotherapy. The femur was the most common location in 15 patients.

All the patients had chemotherapy according to the protocol current at the time of treatment. 7 patients had radiotherapy alone while 25 patients underwent surgical excision and reconstruction. Of the patients who had surgery, 7 patients had adjuvant radiotherapy. Fracture healing was the norm after pre-operative chemotherapy. Surgical margins were wide in 17 patients, marginal in 4 and intralesional in 3 patients.

Local recurrence developed in one patient (3%). Metastases occurred in 12 patients (37%). At the time of review 16 patients were free of disease, 3 were alive with disease and 13 patients had died of disease. The cumulative 5 year metastases free and overall survival in all the patients was 58% and 61 % respectively and similar to patients with Ewing’s sarcoma without fracture treated at our centre. The prognosis of patients who presented with fracture was exactly similar to those who developed fracture in the course of treatment.

We conclude that limb preserving surgery is perfectly safe in patients with Ewing’s sarcoma who have associated pathological fracture and survival is not in any way compromised. Survival of patients who present with fracture is similar to those who develop fracture in the course of treatment. The exact role of adjuvant radiotherapy in these patients needs to be clarified.


C J McNair R Hamilton D E Boddie I Kelly

Aim: To review the prognosis of Pelvic Osteosarcoma in the files of the Scottish Bone Tumour Registry between 1955 and 2001.

Text: The cases of 40 consecutive patients with osteosarcoma of the pelvic ossea registered in the files of the Scottish Bone Tumour Registry between 1955 and 2001 were reviewed. 6 of these patients had underlying Paget’s disease and 2 had received previous radiotherapy to the pelvis. The median age at diagnosis was 60 years (mean 55.7 years). 12 patients had distant metastases at initial presentation (Enneking stage III). 24 patients had stage IIB ostesarcomas, 3 patients had stage IIA osteosarcomas and 1 patient had stage IB osteosarcoma. The median survival of stage IIB and stage III ostesarcoma was 9.5 months (1–39 months) and 5.5 months (0.5–16 months) respectively. The median age of survival for stage IIB tumours treated prior to the introduction of chemotherapy was 9 months (1–30 months) compared to those whose treatment included chemotherapy of 12 months (4–39 months). 5 of the 40 patients treatment regimens included surgical intervention- all had stage IIB tumours. The median survival for this group was 13 months (4–39 months).

Conclusion: Despite the introduction of modern multimodality treatment regimens the prognosis for pelvic osteosarcoma remains poor.


A Malviya S Barnard SA Murray R Milner CH Gerrand

Aims: Bone and soft tissue tumours not infrequently arise from the chest wall. Resection may require removal of ribs and reconstruction using mesh, biological materials such as lyophylised pig skin and muscle flaps. The purpose of this study was to review the experience of our multidisciplinary team in the management of chest wall resections for bone and soft tissue tumours. Patients and methods: This was a retrospective review of patient records. Between 2001 and 2005, 20 patients of mean age 50.3 years (13 to 92) underwent resections involving the chest wall. Ten were male.

Results: The diagnosis was chondrosarcoma in 8, osteosarcoma in 3, PNET/Ewings in 2, MPNST in 2, sarcoma NOS in 2, and one each of leiomyosarcoma, pleomorphic MFH, and metastatic renal carcinoma. 15 patients underwent rib resection, four sternal resections and one tumour of the clavicle was removed with the underlying rib. In 3 cases a latissimus dorsi flap was used as part of the chest wall reconstruction. The surgical margins were intralesional in 5, marginal in 11 and wide in 4 cases. Two patients died following a complication of treatment. Four patients died at a mean of 6 months (4 to 8 months) from metastatic disease. Two patients had local recurrence. At a mean follow up of 26 months (4 to 58) twelve patients were alive without evidence of disease, and two were alive with metastatic disease.

Conclusion: Chest wall resection for malignant bone or soft tissue tumours is feasible and can be achieved safely. However, there is a significant mortality rate associated with this procedure. This procedure demonstrates par excellence the value of multidisciplinary team working. Local anatomical constraints may mean that achieving a wide surgical margin is not always possible.


T Theologis S Matthews C L M H Gibbons A Wainwright G Kamboroglou

The management of pathological fractures in children remains controversial. The indications for surgical treatment are unclear and the need for histological diagnosis before or after definitive treatment is not clearly defined.

We reviewed retrospectively the records of all patients under the age of 16 years who presented over the past 7 years with a fracture as the first manifestation of bone pathology. There were 26 patients (19 boys and 7 girls) of an average age of 12 years and 2 months (range 4.1–15.8 years).

There were 9 cases of fracture through a simple bone cyst, 6 in the humerus and 3 in the femur. In all cases the fracture was treated conservatively initially. Subsequent management included needle biopsy in all, followed by bone marrow injection under the same anaesthetic. The patients suffered a refracture and were treated with flexible intra-medullary nail fixation.

There were 5 cases of fibrous dysplasia, of which 2 in the femur, 2 in the tibia and one in the proximal radius. Histological diagnosis was obtained in all cases prior to definitive treatment. This included a locked intra-medullary nail in one patient and flexible nailing in another two. The remaining two patients are still under observation.

There were 2 patients with giant cell tumour, 3 patients with aneurysmal bone cyst and one patient with chondroblastoma. Histological diagnosis preceded treatment with curettage and grafting in all these cases. There were 6 patients with malignant primary bone tumour, 1 adamantinoma, 2 osteosarcoma, and 3 with Ewings Sarcoma.

The 3 patients with Ewing’s sarcoma involved the femur. One had extensive local disease and early intra-medullary nailing was performed for palliative reasons. The second patient was treated conservatively initially. Definitive surgery was performed after fracture healing and included segmental resection and vascularised fibular graft. The third patient was initially treated elsewhere. She was thought to have a benign lesion and internal fixation with a screw/plate device was performed. Histology from intra-operative specimens confirmed Ewing’s sarcoma. Definitive surgery required extensive resection and prosthetic replacement.

The 2 patients with osteosarcoma had fracture of proximal humerus and distal femur. The former was treated by forequarter amputation as there was tumour involvement of brachial plexus and remains AWND at 7 years. The latter had resection and EPR of the distal femur.

One patient with adamantinoma underwent segmental resection and reconstruction with VFFG

We recommend that primary fixation of pathological fractures should be avoided until histological diagnosis is obtained. However, if radiographic appearances are reassuringly benign, biopsy can be delayed until conservative fracture management is completed. Definitive treatment of benign lesions with protective intramedullary nailing or curettage and grafting can follow frozen section under the same anaesthetic.


S Bhagat H Sharma DS Pillai MJ Jane R Reid

Between 1948 and 2004, we report 34 patients with Ewing’s sarcoma of pelvis accrued from Scottish Bone Tumour Registry, aiming to identify the prognostic factors and the influence of various treatment modalities on outcome. There were 19 male and 15 female patients at a mean age of 19 years (range, 3 to 48 years). The Pain was main presenting symptom in 30, swelling in 12 and restriction of hip movements in 11 patients. The commonest anatomical site was ilium. Local control was achieved by surgery, radiotherapy (n=25), chemotherapy (n=23) or a combination. The survival correlated significantly with chemotherapy protocols in favour of the group that received ifosamide (p< 0.01). Metastases at presentation was the most important factor determining survival (P< 0.01). Among the patients who presented without metastases (n=25), there was no statistically significant difference in survival based on the anatomical location of the tumour, age or sex. The mean time to lung metastases from the date of presentation was 13 months, while bone metastases presented at an average of 20 months. None of the patients with the metastasis or local recurrence survived. There were 5 local and 17 systemic (metastatic) relapses. The mean duration of survival was 13 months.

With advances in imaging, aggressive chemotherapy, surgery and conformal radiotherapy which can deliver high dose of radiation with precision, it is possible to achieve a cure rate of more that 50% in non-metastatic pelvic Ewing’s sarcoma. The results of this study favour a middle-path regime combining all treatment modalities.


K Godley AC Watts JE Robb

Background:The study aimed to analyse the demographic, clinical, and histological features of patients with a malignant primary bone tumour of the femur presenting with a pathological fracture.

Methods: Eighty-six patients with primary malignant bone tumours of the femur presenting with pathological fracture were identified from a unique national database that contains original radiographs, casenotes and histology for all patients diagnosed with a primary bone tumour since september 1936 to the present. Demographic data, presenting features, tumour location, histological diagnosis, treatment, local recurrence, metastasis and survival data were gathered.

Results: The median age was 63 years (range 4 to 87 years) and 47% were men. Forty-two percent of patients presented with a history of trauma. Forty percent of lesions were in the proximal femur, 34% in the diaphysis and 26% in the distal femur. The most common histological diagnoses were osteosarcoma (13 patients), Paget’s sarcoma (12 patients), myeloma (11 patients), chondrosarcoma and lymphoma (9 patients each). Other diagnoses were fibrosarcoma, Ewing’s sarcoma, spindle cell sarcoma, reticulum cell sarcoma, malignant fibrous hystiocytoma, and malignant giant cell tumour. The local recurrence rate was 31%. The median survival was 12 months (95% confidence interval 6 to 18 months). Overall 5 and 10-year survival were 22.4% and 17.4% respectively. Specifically for osteosarcoma, chondrosarcoma and Paget’s sarcoma the five year survival rates were 15.4%, 11.1% and 19.0% respectively. Those in whom the age at the time of presentation was over 60 years had a significantly worse prognosis (log rank 13.4, p< 0.001).

Conclusion: Pathological fracture as a presenting symptom of primary malignant bone tumours is associated with a poor prognosis in nearly all tumour types studied. The prognosis is worse in those who are over 60 years at the time of presentation.


E Shears K Dehne H Murata A Abudu

Purpose of study: Curettage with bone grafting is the accepted method of treating benign tumours of the talus. However, the natural history of ungrafted defects at this site is unknown. We report a series of 8 patients (6 male and 2 female) who underwent curettage of the talus without subsequent bone grafting.

Methods and results: 6 patients had chondroblastoma, one had osteoblastoma and one had an intraosseous ganglion. 4 lesions were located in the talar neck, 3 in the talar dome and one in the talar body. Mean age at presentation was 21.7 years. Mean tumour volume was 16cm3 (range 3.5–48cm3). Post-surgical follow-up was collected at a mean of 35 months (range 5–84 months).

The bone defect consolidated fully, with no talar collapse, in all 8 cases. 5 of the 8 patients had no pain and full range of movement at last follow-up. 4 patients had no evidence of osteoarthritis at last follow-up, 2 patients had OA grade 1, one had OA grade 2, and one had OA grade 3 pre-operatively which then progressed to grade 4. One patient had two episodes of local recurrence which were treated by curettage and bone grafting, then by radioablation.

Conclusion: Our results suggest that curettage alone leads to good consolidation of talar defects without an increase in complications. We conclude that bone grafting is not a necessary adjunct to the curettage of talar lesions.


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H Murata S Kalra H Ahrens A Abudu RJ Grimer SR Carter RM Tillman

99 patients with new diagnosed soft tissue sarcomas involving the pelvic region were studied to determine the outcome and prognostic factors for survival and local recurrence.

The mean age at diagnosis was 57 years. There were 55 males and 44 females. The mean tumor size was 12cm. The tumor was deep in 79 patients and superficial in 20. Surgical treatment was excision in 93 patients and hindquarter amputation in 6 patients. Histological grade was low grade in 23 and high grade in 75 patients. 7% of the patients had metastases at presentation.

The 5 year overall survival was 57% and local recurrence occurred in 22% of the patients. The risk of inadequate surgical margins in patients with tumors within the pelvic brim was 50% compared to 18% for those with tumors located outside the pelvic brim. The significant predictors of local recurrence were inadequate margins and location of the tumor within the pelvic brim. Tumor size, grade and depth did not influence development of local recurrence. Significant predictors of survival included metastases at presentation, tumor grade and depth. The cumulative 5 year survival for patients with deep high grade tumors, deep low grade tumors, superficial high grade and superficial low grade tumors were 45%, 74%, 63% and 100% respectively (p=0.01). The 5-year overall survival was 66% in those patients without local recurrence compared to 37% in those who develop local recurrence (p=0.005). Multivariate analysis revealed that development of local recurrence was the most important determinant of overall and metastases free survival.

We conclude that patients with pelvic soft tissue sarcoma who develop local recurrence have an extremely poor prognosis. Patients with high grade and inadequate surgical margins represent a particular group with very high risk of metastases and death even with radiotherapy and perhaps should be considered for other adjuvant treatment.


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C L M H Gibbons S Gwilym H Giele D J Whitwell P Critchley N Athanasou

Aim of Study: Assess clinical outcome and function of planned marginal excision of low grade liposarcoma of the forearm.

Material and Methods: Between 1997 and 2005 15 of 27 soft tissue sarcomas of the forearm were liposarcoma.

13 presented in the extensor compartment and 2 flexor compartment at the level of the distal radius. All presented with a painless mass. 5 patients with neurological symptoms. 4 involving the post interosseus nerve and 1 radial nerve. MRI was the diagnostic imaging technique of choice, 2 had biopsies where there was atypical imaging features.

Treatment and Results: All treated by planned marginal excision in view of proximity of neurovascular structures. The majority of tumours of the extensor compartment of the forearm were either involving or abutting the post interosseus nerve or neurovascular conduit.

All underwent planned marginal excision preserving juxtaposed peripheral nerve. There were no radial, spiral or PIN nerve palsies. One patient presented with PIN palsy had partial resolution of symptoms and function. I wound infection

Conclusion: Low grade lipoma-like liposarcomas have low metastatic potential. In the forearm a wide margin would mean ablation of critical neurological structures and planned marginal excision results in good function and to date no evidence of local recurrence at 2–9 year follow up.


S W Hamilton E MacDuff D E Boddie T R Scotland R Reid

Purpose: To evaluate the clinico-pathological features and outcome of osteosarcoma in patients over the age of 40 in Scotland.

Methods: A retrospective review was performed using data collected by the Scottish Bone Tumour Registry on patients diagnosed with osteosarcoma over the age of 40 between 1960 and 2004. Information about tumour location, age of diagnosis, gender, lung metastasis, and survival was analysed. Histological slides were reviewed again and the diagnosis of osteosarcoma confirmed. The overall survival was calculated using Kaplan-Meier survival curves.

Results: 145 patients were identified. 78 patients had malignant change in pre-existing Paget’s disease. 60 patients had osteosarcoma and 18 malignant fibrous histiocytoma. Average age of diagnosis of Paget’s osteosarcoma was 67.8 years, male to female ratio of 2:1 and 27% of cases were within the pelvis. Median survival was 6 months. 30% had lung metastasis at presentation.

54 patients had conventional osteosarcoma. Average age of diagnosis of 58.8 years, male to female ratio of 3:2 and 37% were femoral. Median survival was 11 months.

13 patients had radiation-induced osteosarcoma. Average age of diagnosis of 67.2, male to female ratio of 1:6 and 5 out of the 13 had pelvic osteosarcoma. Median survival was 8 months.

Conclusion: We present the clinico-pathological features and outcome of osteosarcoma in patients over the age of 40 in Scotland between 1960 and 2004. Pelvic disease and metastasis at presentation were prevalent in patients with Paget’s and radiation-induced osteosarcoma reflecting their poor outcome.


S Bhatnagar F Fiorenza JA Bramer RJ Grimer SR Carter RM Tillman A Abudu

Aim: To identify tumour and treatment factors significant for both local control and survival for patients with chondrosarcoma of the pelvis.

Method: The features of all patients with non metastatic chondrosarcoma of the pelvis treated at a tertiary treatment centre between 1971 and 2001 with more than 2 years of follow-up were analyzed.

Results: There were 106 patients with a median age of 44. There were equal numbers of male and female patients in the group. The median size of the tumours was 12cm. 47 tumours were grade 1, 37 were grade 2 and 22 were grade 3. Treatment involved hindquarter amputation in 33 and excision with or without reconstruction in 73. Clear margins (wide or better) were achieved in 34 cases. The excision was marginal in 30 cases and intralesional or contaminated in 37. Local recurrence arose in 39 patients and was related to adequate margins of excision (p=0.03) and grade (p=0.01). Overall survival was 72% at 5 years, 56% at 10 years and 46% at 15 years. Survival was strongly related to grade (p=0.08) but survival beyond 5 years was most strongly related to the adequacy of the excision margins.

Conclusion: Tumour grade is the most important prognostic factor for chondrosarcoma of the pelvis but the ability to obtain clear margins of excision influences both local control and the prospects for long term survival.


K Dehne E Shears H Murata A Abudu

We report the results of contained bone defects after curettage of benign bone tumours of the distal radius treated without bone grafting or the use of bone substitute. 11 consecutive patients treated with follow-up of 3 to 11 years (mean 5.7 years) were studied. The mean age at diagnosis was 27 (range 11 to 55). There were7 males and 4 females. Histological diagnosis was giant cell tumour in 8 and aneurismal bone cyst in 3 patients. The mean bone defect at diagnosis was 23.7cm3 (9.2 – 68cm3). Pathological fracture was present in 5 patients prior to surgery. We observed full radiological consolidation of the defects in all the patients within 12 months of surgery. Radiologically detectable osteoarthritis was noted in 5 patients (grade 1 in two patients, grade 2 in one and grade 4 in two patients). Development of osteoarthritis was significantly related to size of the defect and involvement of the joint by the original tumour. No patient without joint involvement developed osteoarthritis. There was no relationship between pathological fracture and development of osteoarthritis.

We conclude that contained bone defects in the distal radius do rapidly consolidate without the use of bone grafting or bone substitute. The bone remodels nicely over time. Development of osteoarthritis is related to the damage to the articular defect caused by the tumour.


H Murata S Kalra A Abudu SR Carter RM Tillman RJ Grimer

Synovial sarcoma is a morphologically well-defined neoplasm that most commonly occurs in soft tissue accounting for 5% to 10 % of all soft tissue sarcomas. We reviewed 156 patients with synovial sarcoma of soft tissues treated at a supra-regional centre to determine survival and prognostic factors.

There were 77men and 79 women with mean age at presentation of 38 years (3 to 84). Follow-up periods ranged from 3 to 494 months (median 43 months). Tumor was located in lower extremities in 111patients, upper extremities in 34 patients, and trunk and pelvis in 11 patients. Overall survival was 66% at 5 years and 48% at 10 years. The 5 and 10 year survival for the 23 patients who had metastases at the time of diagnosis was 13% and 0% respectively compared to 75% and 54% for those without metastases at diagnosis. Local recurrence occurred in 18 patients (13%). The significant prognostic factors for survival included presence of metastases at diagnosis and development of local recurrence. Tumour size and depth, age of patients and use of chemotherapy did not significantly influence survival.

We conclude that the clinical factors which influence survival of patients with synovial sarcoma are different from those of soft tissue sarcomas in general. Biological factors may better predict prognostic survival than the usual clinical factors.


S Kalra R Grimer D Spooner S Carter R Tillman A Abudu

Aim: To identify patient, tumour or treatment factors that influence outcome in patients with radiation induced sarcoma of bone.

Method: A retrospective review of an oncology database supplemented by referral back to original records.

Results: We identified 42 patients who presented to our Unit over a 25 year period with a new sarcoma of bone following previous radiotherapy. The age of the patients at presentation ranged from 10 to 84 years of age (mean: 17 years) and the time interval from previous radiotherapy ranged from 4 to 50 years (median: 14 yrs; mean: 17 years). The median dose of radiotherapy given had been 50 Gy but there was no correlation of radiation dose with time to development of sarcoma. The pelvis was the most common site for development of sarcoma (14 cases) but breast cancer was the most common primary tumour (8 cases). 9 of the patients had metastases at the time of diagnosis of the sarcoma. Osteosacoma was the most common diagnosis (30). Treatment was by surgery and chemotherapy when indicated and 30 of the patients had treatment with curative intent. The survival rate was 41% at 5 years for those treated with curative intent but in those treated palliatively median survival was only 6 months and all had died by one year. The only factor found to be significant for survival was the ability to completely resect the tumour, thus limb sarcomas had a better prognosis (66% survival at 5 years) than central ones (12%)(p=0.009).

Conclusion: Radiation induced sarcoma is a rare complication of radiotherapy. Both surgical and oncological treatment is likely to be compromised by previous treatment the patient has received. Despite this 40% of patients will survive more than 5 years with aggressive modern treatment.


D Cumming A Vince R Benson

To assess the referral system and the clinical notes and radiographs of patients presenting with metastatic disease of long bones.

All oncology consultants and registrars received a questionnaire regarding referral to the orthopaedic department for metastatic disease of the appendicular skeleton.

Ninety three percent of oncologists did not use a reliable scoring system to assess risk of pathological fracture. The majority of oncologists referred with regards to degree of cortical erosion and increased pain on weight-bearing. Sixty percent felt an improvement in communication between the departments was required.

The notes and radiographs were reviewed of twentyfive patients presenting with femoral metastatic lesions to the oncology department.

Mirels scoring system was then applied to each patient to assess the risk of the possibility of a pathological fracture.

Ten patients had a Mirels score of greater than eight. Three patients were referred for an Orthopaedic opinion regarding prophylactic fixation. Two patients had no fracture of the femur after three months. Five patients had a pathological fracture within three months, resulting in an emergency admission for surgery.

Three patients had a Mirels score of 8. One patient suffered a pathological fracture.

Twelve patients had a Mirels score of less than 8. None of these patients were referred for an Orthopaedic opinion. None of these patients had a pathological fracture within three months.

In conclusion, we presently do not offer a multidisciplinary approach to metastatic disease affecting the appendicular skeleton.

The majority of patients’ who score eight or above in the Mirels scoring system are at risk of fracture and do require prophylactic surgery.

In keeping with the BOA guidelines, “Metastatic Bone Disease: A Guide to Good Practice”, we would recommend the introduction of a multidisciplinary approach and the use of a recognised scoring system to improve patient care.


DH Park OM Stokes J Jagiello RC Pollock JA Skinner SR Cannon TWR Briggs

Purpose: We report the clinical and functional outcome of limb salvage surgery and endoprosthetic reconstruction of the distal tibia and ankle joint in 5 patients.

Introduction: The distal tibia is an uncommon site for primary malignant bone tumours and the treatment of choice for most patients is a below knee amputation. Patients who decline an amputation may be offered an endoprosthetic replacement. This is a technically challenging operation and may be associated with high morbidity.

Methods and Results: Over 25 years at our centre, 5 patients underwent distal tibial replacements for bone or soft tissue sarcomas. Two had osteosarcoma, one had a recurrence of Ewing’s sarcoma, one had malignant fibrous histiocytoma, and one had an adamantinoma. The mean age was 37 years (13 to 69 years). There were no tumour recurrences. Four patients developed complications with wound infection. Two of these resulted in below knee amputations. Average follow-up was 31 months (19 to 55 months) with 1 patient lost to follow-up. Patients were evaluated using the Toronto Extremity Salvage Score (TESS) and the Musculoskeletal Tumour Society (MSTS) score. The mean MSTS score was 88% and the mean TESS was 88.5%. Two patients who later had a below knee amputation and who were using a prosthesis averaged an MSTS score of 86.3% and a TESS of 89.3%.

Conclusion: For those patients who are unwilling to undergo an amputation for malignant tumours of the distal tibia, endoprosthetic reconstruction is an alternative, but at the cost of increased risk of significant complications, functional deterioration and morbidity. There was little difference between functional scores for patients who proceeded to have a below knee amputation compared to patients who still had their endoprosthesis


AK Bhadra ATH Casey

Purpose: To report the genetic correlation of familial chordoma, a rare tumour of embryonic notochordal remnant.

Method: We present two patients with a family history of chordoma. Both patients had surgery at our unit, one for a clival and one for a sacral tumour. These two cases comprise 1.14% (2 out of total 175 chordoma cases) of our unit’s surgical experience with chordoma (79 cases involving craniocervical junction, 4 cases involving thoracolumbar spine, 92 cases involving sacral region) over the period of 15 years (1990– 2005). Patient1 had clival chordoma and Patient2 had sacral chordoma. Both the patients had excision of the tumour followed by postoperative radiotherapy and annual follow up. There was no recurrence eight years later in Patient 1 and Patient 2 died three years after the surgery.

Results: Patient 1 had ten other family members affected by chordoma (mostly clival) and Patient 2 had two other family members affected by clival chordoma. Genetic analysis for the Patient 1 and of her relatives (National Cancer Institute, Bethesda) showed that there was loss of heterozygosity on chromosome 7q 33. None of the affected members of the Patient 2 were alive to do the genetic study.

A literature search on genetic studies was performed using the key term as familial chordoma and following studies have been found-

Kelly et al- the study had 10 affected members and showed linkage to chromosome 7q 33.

Miozszo et al- the study had 3 affected family members and showed tumour suppressor locus on chromosome 1p36.

Stepanek et al –the study had affected 4 members in a family and showed probable autosomal dominant inheritance.

Conclusion : Familial chordoma is a very rare tumour. Further genetic studies will hopefully reveal valuable insight into the pathogenesis and possible therapeutic measures of this tumour.


A Mahendra M J Jane M Mullen H Sharma B Rana

Limb salvage surgery includes all of the surgical procedures designed to accomplish removal of a malignant tumour and reconstruction of the limb in order to achieve an acceptable oncological, functional, and cosmetic result. The aim of this study was to evaluate the functional outcome following endoprosthetic replcament for primary upper & lower extremity musculoskeletal neolplasms.

Between 1983 and 2004, we found 68 patients from the Scottish Tumor Register having had an endoprosthetic reconstruction for upper and lower-extremity malignant musculoskeletal tumours, of which 32 were alive for performing functional assessment (lower extremity-26, upper extremity-6). The clinical, radiological and oncological outcomes were evaluated. The functional outcome was measured by the Musculoskeletal Tumor Society and Toronto Extremity Salvage Score.

The average follow-up was 59 months (range, 1 to 21 years). There were 19 female and 13 male patients. These were anatomically distributed as around the knee (n=18 cases), hip (n=8) and shoulder (n=4). The most common diagnosis was chondrosarcoma (n=10) and osteosarcoma (n=11). Most of the patients were completely satisfied with their condition, with a decreased walking distance as the only notable restriction. There was no correlation between the functional outcome and the type or site of resection. Complications occurred in ten cases, including two cases of aseptic loosening and one case each of recurrent instability, sciatic nerve palsy and femoral nerve palsy. The median functional score using the Musculoskeletal Tumour Society system was 56% and Toronto Extremity Salvage Score was 72%.

Limb salvage for malignant musculoskeletal tumours continues to pose therapeutic and oncological challenges with considerable functional issues, but the good function and local tumour control in most patients justifies its continued use.


J Paniker A Abudu SR Carter RM Tillman RJ Grimer

Purpose: To study the results of treatment of symptomatic non-union with endoprosthesis at the Royal Orthopaedic Hospital

Methods: Between 1987 & 2005, 17patients were treated with massive endoprosthesis for non-union. We performed a retrospective review of these case notes

Results: Mean age at diagnosis was 63years (range 36–86). Location of non-union was distal femur in 9, proximal femur in 4, proximal humerus in 2, proximal tibia in 1, distal humerus in 1. The majority of the patients had received prior multiple operations before endoprosthetic surgery.

Four patients had obvious infection confirmed by histology and/or microbiology prior to surgery. Endoprosthetic Reconstruction was performed as a 1 stage procedure in 13 and as a 2 stage in 4.

Complications occurred in 5 patients. These included recurrence of infection in 1, persistent pain in 1, aseptic loosening in 1, periprosthetic fracture in 1 and a non ST myocardial infarction in 1. At the last follow-up, (mean 5years, range 1–18years) majority of patients achieved good range of motion and good mobility.

Conclusion: We conclude that endoprosthetic replacement is a reasonable option for treatment of end-stage non-union in carefully selected patients. Adequate mobility and function can be achieved in majority of patients following such treatment


S.P. Kelley R.U. Ashford A.S. Rao R.A. Dickson

Purpose: We conducted a review of the Leeds Regional Bone Tumour Registry for primary bone tumours of the axial skeleton since establishment in 1958 until year 2000 to analyze the incidence of primary tumours of the axial skeleton and to record their site of occurrence, sex distribution, survival and pathology.

Method: Primary tumours of the axial skeleton are particularly rare, accounting for between 4% and 13% of published series of primary bone tumours. The Leeds Bone Tumour Registry was reviewed and a total of 2750 cases of bone tumours and tumour-like cases were analyzed. Consultants in orthopaedic surgery, neurosurgery, oncology and pathology in North and West Yorkshire and Humberside contribute to the Registry.

Results: Primary bone tumours of the axial skeleton constitute only 126 of the 2,750 cases (4.6%). Chordoma was the most frequent tumour in the cervical and sacral regions, while the most common diagnosis overall was myeloma. Osteosarcoma ranked third. Mean age of presentation was 42 years. Pain was the most common presenting symptom, occurring in 95% of malignant and 76% of benign tumours. Neurological involvement occurred in 52% of malignant tumours and usually meant a poor prognosis,

Conclusions: The establishment of Bone Tumour Registries is the only way that sufficient data on large numbers of these rare tumours can be accumulated to provide a valuable and otherwise unavailable source of information for research, education and clinical follow-up.


P Mohanlal N MayilVahanan JC Bose R Gangadharan

Purpose Of The Study: To find the functional and oncological outcome of patients who underwent limb salvage surgery and custom mega prosthesis for Malignant Fibrous Histiocytoma of bone.

Methods And Results: Twenty patients with histologically diagnosed Malignant Fibrous Histiocytoma of bone were treated by resection and reconstruction with custom mega prosthesis between May 1991 and December 2002. The average age was 42 and two-thirds of the patients were males. Majority of the tumours were located around the knee and were in Stage II disease of the Enneking system. Wide margins of resection were achieved in 18 patients and reconstruction was done with total knee prosthesis in patients with distal femoral and proximal tibial tumours. The proximal humeral and proximal femoral sites were reconstructed with their respective prosthesis. Fourteen patients treated after 1996 received chemotherapy. With an average follow-up of 57.7 months, 4 patients had amputation for local recurrence and five patients died of disease. Two patients had fracture of prosthesis necessitating revision of prosthesis in one. Functional result was excellent in 5 patients and good in 9 patients. The Kaplan-Meier 5-year survival rates of the patients treated without chemotherapy and with chemotherapy were 50% and 75.8% respectively.

Conclusion: MFH is an aggressive malignant tumour with a poor prognosis. A combined approach using neoadjuvant chemotherapy together with adequate surgical margins improves survival.


M Ali P Harrington

We report the case of an 80-year-old woman treated by palliative knee arthrodesis for metastases of the proximal left tibia secondary to bladder carcinoma, using percutaneous femortibial intramedullary arthrodesis nailing.

The technique provided a simple alternative to massive allografting, total joint prosthesis or amputation, with advantages of low morbidity, short operating time, minimal blood loss, immediate ambulation and weight bearing, relief of pain, restoration of independence, and ease of nursing care.

We are satisfied with the procedure of percutaneous femorotibial intramedullary nailing as a palliative treatment of proximal tibial metastases in an elderly patient.


Vinayagam LeninBabu Thomas Wade Garwi Choy Ashok Paul

Introduction: Haemorrhagic Epithelioid and Spindle Cell Haemangioma (HESCH) is a new entity that was first described by Rosenberg in 1999. We report the first instance of this tumour occurring in pelvis along with literature review.

Case Report: A 65 year-old man presented with complains of pain in left hip radiating to leg of 5 months duration. X-ray & MRI scan (Fig 1, 2, 3) of his pelvis showed lytic destructive lesion in the left inferior pubic rami. Trucut biopsy showed it as a HESCH with no evidence of malignancy (Fig. 4). He successfully underwent pre op. embolization and excision of the tumour including the ischium. His symptoms started to subside within 4 weeks of surgery and he is remaining pain free at one year follow up.

Discussion: Although endovascular tumours are relatively common in soft tissues, for them to be present in the bone is very rare. This is the first reported case of HESCH occurring in the pelvis, as previous cases tend to occur in the small bones of the hands and feet and were thought to be confined to the distal extremities. The age of this patient is also a point of interest, as he is over 2 decades older than the oldest, previously reported case. Histologicaly, a mixture of both epithelioid and spindle cells are seen which grow in a lobular pattern. As the tumour grows, it can lead to destruction of bone. It is important to note that this is a benign tumour with good prognosis.

Conclusion: This case report highlights the good prognosis associated with this form of benign tumour and that embolisation and curettage are the most effective treatment methods.


S Kalra R J Grimer S R Carter R M Tillman A Abudu

Introduction: The population of the UK is getting older. Patients over the age of 80 (the older old) are increasingly presenting with musculoskeletal tumours that require major surgery. We have investigated the success or otherwise of endoprosthetic replacements after tumour excision in this population.

Methods: We looked at an oncological database to identify patients over the age of 80 who had an endprosthetic replacement after tumour excision. We reviewed the records of all patients over the age of 80 who had an endoprosthetic replacement to assess the oncological and functional outcomes of the procedure.

Results: 17 patients over the age of 80 had an endoprosthesis over the past 10 years. The main indication was for metastatic disease (9 patients) but 6 had primary malignant bone tumours. The most common site was the distal femur in 9 followed by the proximal femur in 5. Most of the patients had associated co-morbidity (12 were ASA 2 or 3). There were no perioperative deaths but 2 patients had early complications with one having a paralytic ileus and one a chest infection. The median survival of the patients was 2 years with death being due to progressive metastases in most. 3 had late complications to do with the prosthesis including one infection in a proximal tibial replacement and a late dislocation at 2 years in a proximal femoral replacement. Two patients developed local recurrence treated by local excision and radiotherapy. There were no amputations or revisions.

Conclusions: Endoprosthetic replacements have a useful role to play in the surgical management of elderly patients. Although they have significant comorbidity most do well. Functional results are less good than in the younger population but most patients regain their independence and are free of pain.


KAZ Sivardeen H Iqbal A Abudu

Background: The dorsal wrist ganglion is one of the commonest tumours to be found in the upper limb. Aims: We aimed to find out how specialist upper limb surgeons managed this common condition, and to propose best practice guidelines.

Methods: We sent a standard questionnaire by email to 100 hand surgeons who were members of the British Society for Surgery of the Hand.

Results: 62% returned the completed questionnaire. 93% routinely used a tourniquet, 73% used general anaesthetic. 83% would not use Xray or further imaging. 62% would operate on less than 10 a year or as few as possible. Only 42% routinely sent tissue for histology and 71% used a transverse incision.

Discussion and Conclusions: Most upper limb surgeons diagnose a ganglion clinically, use a transverse incision for excision and do not routinely send tissue for histology. We believe that ganglia should be treated like other neoplasms and excised via a longitudinal incision and tissue sent for histology. We present a series of cases which were thought to be simple ganglia, but histology revealed different pathology. The use of a transverse incision, may compromise definitive excision at a later date, if histology revealed a malignant neoplasm. A transverse incision has not been shown to give superior results in terms of cosmesis, and is also associated with an increased risk of painful neuroma formation after damage to the superficial radial nerve.


R. Kakar S Kakar H Sharma M H Durrani

Primary lymphomas of bone are uncommon malignancies with involvement of spine, long bones, pelvis, ribs and skull in decreasing order of frequency. We describe an unusual case who presented with recurrent knee effusions turned out to be a high grade B-cell non-Hodgkin lymphoma.

A 34-year-old man is presented with painful recurrent knee effusions without any systemic aberration. Multiple aspirations were carried out to help knee pain and swelling with immediate response, but had negative cytology. Hematological and biochemical parameters were normal. Plain radiographic examination of the knee failed to show any bony abnormalities. An MRI scan of the knee showed extensive marrow oedema of the distal femur with breach in the anterior cortex. Subsequently, open biopsy of the lesion was carried out which confirmed the diagnosis of a high grade B-cell Non-Hodgkin lymphoma. Staging CT-scan of the chest, abdomen and pelvis failed to show any other lesions elsewhere. He was subsequently treated with the help of multi-drug chemotherapy and radiotherapy. At 7 months post treatment, the patient had no relapse and a repeat MRI at 7 months showed reduction in the size of lesion.

This case illustrates the limitations of plain radiograph and the usefulness of MRI in the diagnosis of bony lymphoma. The diagnostic dilemmas while investigating recurrent knee effusions due to primary skeletal Non Hodgkin lymphoma should be resolved by timely MRI scan and histological diagnosis.


P Lakshmanan A Malik C Gerrand

Introduction: Brown tumours occur as a complication in patients with renal failure, due to secondary hyperparathyrodism. In these patients brown tumours commonly regress if the primary cause is treated. We present a rare case of recalcitrant brown tumour with unusual presentation and symptom complex requiring surgical intervention.

Case Report: 14-year-old girl with blindness presented with pain in the proximal tibia. Radiographs revealed a lytic lesion in the proximal tibia. Biopsy of the lesion showed osteoclast rich stroma. Blood investigations indicated renal impairment, and secondary hyperparathyroidism. She underwent repeated dialysis treatment, and her renal parameters and parathormone levels were brought back to within normal limits. However, there was no evidence of regression of the lesion. Hence, intralesional curettage of the brown tumour was performed while still maintaining her on regular dialysis. This resulted in complete healing of the brown tumour with no recurrence at latest follow-up. She recently had a renal transplant as a definitive treatment for her renal failure.

Conclusion: The patient in our case has got renal retinal dysplasia which resulted in juvenile renal failure and retinal pigmentary degeneration. The renal failure resulted in secondary hyperparathyroidism leading to the formation of bone tumour in the proximal tibia. Eventhough temporarily the renal parameters were restored to within normal limits, this tumour did not regress in size, and hence required surgical intervention. This case highlights the importance of detailed thorough investigations to find the primary cause and syndrome associated with juvenile renal failure which presented with only a bony abnormality.


M.C. Kokkinakis S. Murray C. Gerrand

Case Report: Metastatic deposits in the proximal femur commonly result in pathological fracture. Conventionally these fractures are treated surgically, by internal fixation or arthroplasty. The emphasis in treating these fractures is on restoring stability to the proximal femur and relieving pain. We present two cases in which pathological fractures of the proximal femur secondary to metastatic renal carcinoma were treated conservatively with excellent functional outcomes. In both cases, the medical condition of the patient precluded surgery. A 68 year old male with a subcapital fracture of the proximal femur was treated with bedrest and mobilisation. At 6 months he was able to mobilise with crutches, swim, and had returned to almost all normal activities despite non-union of the fracture.

A 63 year old male had a pathological fracture of the proximal femur treated by DCS fixation. The fracture failed to unite and the plate fractured. Despite this the patient was able to walk with crutches, pain free. Discussion: After a pathological fracture of the proximal femur conservative management can lead to satisfactory analgesia, function and therefore quality of life.


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Vinayagam LeninBabu Charlotte Brown Tahmeena Dean Ashok Paul

Introduction: The cause for Subungual Exostosis remains unknown, although relationships with trauma, infection and irritation have all been suggested. We report the case of a 23 year old female who developed this condition after Zadek’s procedure done for an in growing toe nail.

Case Report: A 23-year-old woman presented to us with an infected ingrowing great toenail of 1 month duration. An X-ray was performed to rule out osteomyelitis (Figures 1a and 2a), and the patient was put on oral antibiotics to control infection. 12 weeks later, the patient underwent a Zadek’s procedure with uneventful post op. recovery. However, 4 months later the patient came back with increasing pain and swelling in the operated toe. Clinically, there was a shiny nodule measuring 0.5 x 0.5cm over the dorso-medial aspect of the nail bed which was tender to touch, hard in consistency and appeared to be arising from the bone. X-ray’s confirmed it as Subungual Exostosis (Figures 1b and 2b). She successfully underwent excision of the tumour and was symptom free with no signs of recurrence at six-month follow up

Discussion: Our case highlights the fact that Subungual Exostosis may be triggered off by damage to the nail bed during surgeries for ingrowing toe nails and that extreme care must be taken during nail removal to avoid injury to the nail bed. This complication is more pronounced in the presence of pre-existing infection. Excision appears to be the treatment of choice and a biopsy report is always needed for confirmation before discharging the patient from the clinic.

Conclusion: Careful handling of nail bed is necessary during surgery and this unusual complication can be included when taking consent for Zadek’s procedure.


RM Meek H Sharma MJ Jane N Raby E Macduff R Reid

Intraosseous schwannoma is a rare benign neoplasm, which most commonly arises in the head and neck region particularly the mandible, due to the long intraosseous path of sensory nerves in the mandible. We present a 27-year-old lady with an unusual presentation of an intraosseous schwannoma of the first metatarsal. There is only one report published previously of an intraossous schwannoma of the lesser metatarsal bone of the foot.

A 27-year-old woman presented with painful left forefoot following a trip while walking. Plain radiographs demonstrated a pathological fracture through a lytic lesion of the first metatarsal of the left foot. MRI scan using axial T1-weighted spin echo and axial and sagittal T2-weighted gradient echo showed an amorphous mass occupying the medulla of the bone but with a breach of the plantar aspect of cortex with apparent localised destruction. Ultrasound-guided biopsy was performed. Haematoxylin and Eosin stained specimen sections showed a proliferation of spindle cells of alternating hypercellularity and hypocellularity. This case was managed by curettage and grafting with autograft and synthetic bone substitute. At two-year follow-up, the radiographs showed complete graft incorporation and a healed cyst. The patient was clinically asymptomatic with return of full functions. There were no clinico-radiological findings to suggest any recurrence.

Due to rarity and non-specific clinico-radiological features, this case illustrates the necessity of a multi-disciplinary approach with an accurate histological diagnosis in combination with radiological and clinical appearances.


P Lakshmanan AW McCaskie CH Gerrand

Introduction: Short term pain or discomfort after a knee replacement (TKR) is not uncommon, and is usually attributed to the surgical procedure. In this case report, we describe an unusual cause of knee pain following total knee replacement, and remind the reader of the need for a thorough assessment.

Case Report: A 76 year-old male presented with pain in the knee and shin seven months following a TKR on the same side. The pain was dull, aching and constant in nature. There was no other significant past medical history. Pre-operative and immediate postoperative radiographs did not reveal any other abnormality. Clinical examination revealed no evidence of infection, and the motion in the knee ranged from 0–100 degrees. Radiographs revealed a lytic lesion in the proximal tibia just distal to the tibial prosthesis. Further investigations confirmed a diagnosis of renal carcinoma with bone metastases, with one of the lesions appearing in the proximal tibia. The lesion was treated with intralesional curettage, cementing and plate osteosynthesis. The knee pain improved and the mobility was restored. Follow-up radiographs at 6 months showed no evidence of local recurrence.

Discussion: Knee pain following TKR may be attributed to the surgery or the knee implant. However, it is important to keep an open mind about the diagnosis. Local hyperaemia in the metaphysis of proximal tibia following TKR may have resulted in the seeding of metastasis. We elected for primary stabilization of the metastasis with cement and plate, rather than revision of the tibial component with a long intramedullary stem. As a result, rehabilitation was rapid and the risks of revision of the knee prosthesis were avoided.