The foregoing suggestions may be summarised in the following recommendations for the treatment of osteogenic sarcoma.

1. Deep x-ray therapy in high dosage, followed by local resection, should be given serious trial especially: 1) in the upper limb; 2) in the group with atypical clinical or radiographic signs, or histology resembling that of inflammatory lesions; 3) with Grade I histology; and 4) in the young.

2. Deep x-ray therapy followed at once by amputation should be used for osteogenic sarcoma if : 1) local resection would leave a lower limb more unstable than an artificial leg ; or 2) if response to x-rays is poor.

3. Deep x-ray therapy alone should be used: 1) if the patient is unsuitable for, or refuses, any operation ; and 2) palliatively, if metastases are present or the tumour is too advanced, or the patient is not fit for radical treatment.

4. Amputation alone should be used palliatively, for pain or fungation, when x-ray therapy has failed to relieve, or is not readily obtainable.

5. Biopsy and histological grading must be performed in every case. A histological diagnosis is most important. Coley (1949) and MacDonald and Budd (1943) support this view.

6. The records of every possible case should be sent to and discussed by a group with special experience of these tumours.

1. The literature on acute osteomyelitis of the maxilla in infants is reviewed and the improvement in the prognosis since the introduction of chemotherapy is noted.

2. The clinical features, diagnosis, surgical anatomy, pathology, and bacteriology are discussed and the constant pathogenicity of the staphylococcus aureus stressed. It is suggested that the first deciduous molar tooth is the centre of the early bone infection, and that the infection begins in the mucosa overlying this tooth.

3. Two cases are reported. Both were caused by a penicillin-resistant staphylococcus aureus.

4. The early use of aureomycin in an attempt to abort the infection is advocated.

1 . Paralytic talipes calcaneus and calcaneo-cavus are difficult deformities to correct and keep corrected. Many operations have been devised for this purpose.

2. Emslie's operation is a simple procedure by which satisfactory correction can be obtained and maintained. It can be modified to suit individual cases without altering the basic principles of the procedure and is physiologically sound.

3. Illustrative cases are described.

1 . Complications of the Judet arthroplasty are few.

2. The antero-lateral approach provides good access to the joint for insertion of the prosthesis.

3. Details of treatment before and after operation are described and their importance in limiting complications is emphasised.

4. The complications that have been encountered—including dislocation and fracture of the stem—are described and factors in their causation are discussed.

5. Study of the mechanical state of the new joint and the diagnosis of complications are aided by radio-opaque markers in the prosthesis.

1. Radiological investigation of cases of flat foot shows that they form three distinct anatomical types according to the precise level of the break in the arch.

2. When the break occurs at the naviculo-cuneiform joint alone, fusion of this joint in normal alignment should correct the deformity.

3. The results of operation on forty-six feet are analysed. Eighty-two per cent proved satisfactory. Failures are discussed and are considered avoidable by careful selection and operative technique.

1. A case is reported which shows the typical features of osteopathia striata in all the long bones and probably in the pelvis, with the features of osteopetrosis in the skull and ribs.

2. The occurrence of longitudinal striation in osteopoikilosis and osteopetrosis is described, and the possible relationship between these two diseases and osteopathia striata is discussed.

3. The differential diagnosis is indicated.

1. The literature on paraplegia complicating hyperextension injuries of the cervical spine is reviewed, and the lack of any definite explanation of the mode of interference with cord function is noted.

2. A case is described in which a detailed dissection of the post-mortem specimen was carried out. On the basis of the findings it is suggested that one cause of the suppression of cord function in such injuries is thrombosis of the spinal arteries and liquefaction-necrosis of the cord.

An unusual bone tumour complicating Paget's disease of the mandible is described. At the time of local excision the histological appearances were those of a malignant osteoclastoma, but the tumour rapidly recurred as a chondrosarcoma, which spread locally and by metastasis, and caused death within six months.

1. A father and two daughters suffering from Paget's disease are described.

2. The father's case is of special interest because he developed a malignant osteoclastoma of the mandible.

3. In the two daughters the condition was notable for the fact that in each case it began at the age of eighteen in the jaws, and led to the development of osteoporosis circumscripta of the skull.

4. The relationship between Paget's disease and osteoporosis circumscripta, and the age incidence and familial incidence of Paget's disease, are discussed.

1 . The repair of a simple crush injury was studied in rats, in both normally innervated and completely denervated muscle. In each case the histological findings at periods from two hours to thirty-two weeks are described.

2. The denervated muscle showed active and effective repair.

3. A comparison with the findings in normally innervated muscle establishes that the cellular processes of repair do not depend on connections with the central nervous system.

The effect of cortisone on the repair of simple muscle injury was studied in rabbits. The histological findings in the crushed muscle are described for a period up to twenty-one days after injury.

Cortisone defers the onset of muscle regeneration, and retards its progress, but it does not change the course of the repair process or alter its eventual outcome under the conditions of the experiment.

This apparent refractoriness of repair of muscle, as compared with that of other connective tissues, is discussed.

The blood supply of the flexor and extensor tendons of the fingers is described. The blood-vascular system consists of main feeding channels which supply a longitudinal network of vessels. These lie in the interfascicular connective tissue.

A variation of the typical intratendinous vascular pattern in relation to the proximal interphalangeal joint is described.