%0 Journal Article
%A Miao Ma
%A Chongjing Zhang
%A Zeyuan Zhong
%A Yajun Wang
%A Xuegang He
%A Daxue Zhu
%A Zhi Qian
%A Baoqing Yu
%A Xuewen Kang
%T siRNA incorporated in slow-release injectable hydrogel continuously silences DDIT4 and regulates nucleus pulposus cell pyroptosis through the ROS/TXNIP/NLRP3 axis to alleviate intervertebral disc degeneration
%D 2024
%J Bone & Joint Research
%P 247-260
%V 13
%N 5
%R 10.1302/2046-3758.135.BJR-2023-0320.R1
%U https://doi.org/10.1302/2046-3758.135.BJR-2023-0320.R1
%K Intervertebral disc degeneration,oxidative stress,injectable hydrogel,siRNA delivery,polyamidoamine dendrimer,nucleus pulposus cells,intervertebral disc degeneration,Hydrogel,rat models,nucleus pulposus (NP),Mitochondria,RNAs,reactive oxygen species,DNA damage,hyaluronic acid (HA)