Panton-Valentine leukocidin secreted by Staphylococcus aureus is known to cause severe skin, soft tissue and lung infections. However, until recently it has not been described as causing life-threatening musculoskeletal infection. We present four patients suffering from osteomyelitis, septic arthritis, widespread intravascular thrombosis and overwhelming sepsis from proven Panton-Valentine leukocidin-secreting Staphylococcus aureus. Aggressive, early and repeated surgical intervention is required in the treatment of these patients.

The Panton-Valentine leukocidin toxin not only destroys host neutrophils, immunocompromising the patient, but also increases the risk of intravascular coagulopathy. This combination leads to widespread involvement of bone with glutinous pus which is difficult to drain, and makes the delivery of antibiotics and eradication of infection very difficult without surgical intervention.

1. A course of treatment is suggested for patients with stove-in chests based on experience with seven patients, only one of whom died from his injury.

2. The literature on this subject is reviewed and it is suggested that treatment may be undertaken by an accident surgeon without recourse to intermittent positive pressure respiration inmost instances.

1. Fifteen cases of bone transplantation for fibrous union of fractures of long bones are described, using boiled minced cancellous bone from cadavers. One transplant became infected but the infection responded to treatment.

2. In one patient with non-union of the shaft of the humerus, bony union was not obtained, but a good functional result obviated further treatment.

3. It is suggested that this relatively simple method of bone transplantation could be used more widely if its potentialities were appreciated more fully.