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Bone & Joint Research
Vol. 13, Issue 11 | Pages 632 - 646
7 Nov 2024
The antimicrobial properties of exogenous copper in human synovial fluid against Staphylococcus aureus
Diaz Dilernia F Watson D Heinrichs D Vasarhelyi E
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Aims

The mechanism by which synovial fluid (SF) kills bacteria has not yet been elucidated, and a better understanding is needed. We sought to analyze the antimicrobial properties of exogenous copper in human SF against Staphylococcus aureus.

Methods

We performed in vitro growth and viability assays to determine the capability of S. aureus to survive in SF with the addition of 10 µM of copper. We determined the minimum bactericidal concentration of copper (MBC-Cu) and evaluated its sensitivity to killing, comparing wild type (WT) and CopAZB-deficient USA300 strains.

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