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Bone & Joint Research
Vol. 8, Issue 7 | Pages 349 - 356
1 Jul 2019
Starlinger J Kaiser G Thomas A Sarahrudi K

Objectives

The osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) balance is of the utmost importance in fracture healing. The aim of this study was therefore to investigate the impact of nonosteogenic factors on OPG and RANKL levels.

Methods

Serum obtained from 51 patients with long bone fractures was collected over 48 weeks. The OPG and serum sRANKL (soluble RANKL) concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Smoking habit, diabetes, and alcohol consumption were recorded.


The Journal of Bone & Joint Surgery British Volume
Vol. 72-B, Issue 2 | Pages 321 - 322
1 Mar 1990
Thomas A


The Journal of Bone & Joint Surgery British Volume
Vol. 70-B, Issue 4 | Pages 659 - 662
1 Aug 1988
Hoyland J Freemont A Denton J Thomas A McMillan J Jayson M

We examined soft tissue biopsies from 26 patients with symptomatic nerve root fibrosis and arachnoiditis after a previous laminectomy. Dense fibrous connective tissue was found about the nerve roots and in 14 cases (55%) fibrillar foreign material was seen within it. This material had the histochemical characteristics of cotton fibres from swabs and neurosurgical patties. In two other cases nerve root fibrosis was associated with residual radiopaque lipid thought to derive from earlier myelography. Our findings suggest that risks may be associated with the introduction of foreign material into the vertebral canal, and that microscopic fragments of surgical swabs and patties may have a role in the pathogenesis of postoperative periradicular fibrosis.


The Journal of Bone & Joint Surgery British Volume
Vol. 69-B, Issue 5 | Pages 696 - 698
1 Nov 1987
Thomas A Afshar F

The technique and results of microsurgical techniques for lumbar disc protrusions in 60 patients are presented. All patients were followed up for a minimum of 2.5 years, and 91% had good or excellent results. The only patient with a recurrent disc sequestration had a good result after a second operation.