The December 2014 Foot &
Ankle Roundup360 looks at: Charcot feet, biomarkers and diabetes; weight bearing following Achilles tendon rupture; endobuttons and mal-reduced diastasis; evidence for stem cell therapies in osteochondral lesions of the talus; syndesmosis fixation in SER ankle fractures; and self-reporting for foot and ankle outcomes.
The December 2014 Oncology Roundup360 looks at: metaphyseal and diaphyseal osteosarcoma subtly different beasts; sports and endoprosthetic reconstruction of the knee; is curettage without tissue diagnosis sensible in cartilaginous tumours?; autoclaved autograft in bone tumour reconstruction; vascularised graft a step too far in bone defects?; interdigitated neoadjuvant chemoradiotherapy in high-grade sarcoma; predicting life expectancy in patients with painful metastasis; and osteolytic lesions of the hands and feet.
The October 2014 Hip &
Pelvis Roundup360 looks at: functional acetabular orientation; predicting re-admission following THR; metal ions and resurfacing; lipped liners increase stability; all anaesthetics equal in hip fracture surgery; revision hip surgery in very young patients; and uncemented hips.
The June 2014 Knee Roundup360 looks at: acute repair preferable in hamstring ruptures; osteoarthritis a given in ACL injury, even with reconstruction?; chicken and egg: patellofemoral dysfunction and hip weakness; meniscal root tears as bad as we thought; outcomes in the meniscus; topical NSAIDs have a measurable effect on synovitis; nailing for tibial peri-prosthetic fracture.
The June 2014 Wrist &
Hand Roundup360 looks at: aart throwing not quite as we thought; two-gear, four-bar linkage in the wrist?; assessing outcomes in distal radial fractures; gold standard Swanson’s?; multistrand repairs of unclear benefit in flexor tendon release; for goodness’ sake, leave the thumb alone in scaphoid fractures; horizons in carpal tunnel surgery; treading the Essex-Lopresti tightrope; wrist replacement in trauma? and radial shortening reliable in the long term for Kienbock’s disease
The April 2014 Spine Roundup360 looks at: medical treatment for ankylosing spondylitis; unilateral TLIF effective; peg fractures akin to neck of femur fractures; sleep apnoea and spinal surgery; scoliosis in osteogenesis imperfect; paediatric atlanto-occipital dislocation; back pain and obesity: chicken or egg?; BMP associated with lumbar plexus deficit; and just how common is back pain?
Little is known about the incidence of rotator
cuff pathology or its demographic associations in the general population.
We undertook a large epidemiological study of rotator cuff pathology
in the United Kingdom using The Health Improvement Network (THIN)
database. The incidence of rotator cuff pathology was 87 per 100
000 person-years. It was more common in women than in men (90 cases
per 100 000 person-years in women and 83 per 100 000 person-years
in men; p <
0.001). The highest incidence of 198 per 100 000
person-years was found in those aged between 55 and 59 years. The
regional distribution of incidence demonstrated an even spread across
13 UK health authorities except Wales, where the incidence was significantly
higher (122 per 100 000 person-years; p <
0.001). The lowest
socioeconomic group had the highest incidence (98 per 100 000 person-years).
The incidence has risen fourfold since 1987 and as of 2006 shows
no signs of plateauing. This study represents the largest general population study of
rotator cuff pathology reported to date. The results obtained provide
an enhanced appreciation of the epidemiology of rotator cuff pathology
and may help to direct future upper limb orthopaedic services. Cite this article:
Our objective in this article is to test the hypothesis that
type 2 diabetes mellitus (T2DM) is a factor in the onset and progression
of osteoarthritis, and to characterise the quality of the articular
cartilage in an appropriate rat model. T2DM rats were obtained from the UC Davis group and compared
with control Lewis rats. The diabetic rats were sacrificed at ages
from six to 12 months, while control rats were sacrificed at six
months only. Osteoarthritis severity was determined via histology
in four knee quadrants using the OARSI scoring guide. Immunohistochemical
staining was also performed as a secondary form of osteoarthritic
analysis.Objectives
Methods
The December 2013 Research Roundup360 looks at: Inflammation implicated in FAI; Ponseti and effective teaching; Unicompartmental knee design and tibial strain; Bisphosphonates and fracture healing; Antibiosis in cement; Zoledronic acid improves primary stability in revision?; Osteoporotic fractures revisited; and electroarthrography for monitoring of cartilage degeneration
Highly active anti-retroviral therapy has transformed HIV into a chronic disease with a long-term asymptomatic phase. As a result, emphasis is shifting to other effects of the virus, aside from immunosuppression and mortality. We have reviewed the current evidence for an association between HIV infection and poor fracture healing. The increased prevalence of osteoporosis and fragility fractures in HIV patients is well recognised. The suggestion that this may be purely as a result of highly active anti-retroviral therapy has been largely rejected. Apart from directly impeding cellular function in bone remodelling, HIV infection is known to cause derangement in the levels of those cytokines involved in fracture healing (particularly tumour necrosis factor-α) and appears to impair the blood supply of bone. Many other factors complicate this issue, including a reduced body mass index, suboptimal nutrition, the effects of anti-retroviral drugs and the avoidance of operative intervention because of high rates of wound infection. However, there are sound molecular and biochemical hypotheses for a direct relationship between HIV infection and impaired fracture healing, and the rewards for further knowledge in this area are extensive in terms of optimised fracture management, reduced patient morbidity and educated resource allocation. Further investigation in this area is overdue.
Metal artefact reduction (MAR) MRI is now widely
considered to be the standard for imaging metal-on-metal (MoM) hip
implants. The Medicines and Healthcare Products Regulatory Agency
(MHRA) has recommended cross-sectional imaging for all patients
with symptomatic MoM bearings. This paper describes the natural
history of MoM disease in a 28 mm MoM total hip replacement (THR)
using MAR MRI. Inclusion criteria were patients with MoM THRs who had
not been revised and had at least two serial MAR MRI scans. All
examinations were reported by an experienced observer and classified
as A (normal), B (infection) or C1–C3 (mild, moderate, severe MoM-related
abnormalities). Between 2002 and 2011 a total of 239 MRIs were performed
on 80 patients (two to four scans per THR); 63 initial MRIs (61%)
were normal. On subsequent MRIs, six initially normal scans (9.5%)
showed progression to a disease state; 15 (15%) of 103 THRs with
sequential scans demonstrated worsening disease on subsequent imaging. Most patients with a MoM THR who do not undergo early revision
have normal MRI scans. Late progression (from normal to abnormal,
or from mild to more severe MoM disease) is not common and takes
place over several years. Cite this article:
Hip simulators have been used for ten years to determine the tribological performance of large-head metal-on-metal devices using traditional test conditions. However, the hip simulator protocols were originally developed to test metal-on-polyethylene devices. We have used patient activity data to develop a more physiologically relevant test protocol for metal-on-metal devices. This includes stop/start motion, a more appropriate walking frequency, and alternating kinetic and kinematic profiles. There has been considerable discussion about the effect of heat treatments on the wear of metal-on-metal cobalt chromium molybdenum (CoCrMo) devices. Clinical studies have shown a higher rate of wear, levels of metal ions and rates of failure for the heat-treated metal compared to the as-cast metal CoCrMo devices. However, hip simulator studies in vitro under traditional testing conditions have thus far not been able to demonstrate a difference between the wear performance of these implants. Using a physiologically relevant test protocol, we have shown that heat treatment of metal-on-metal CoCrMo devices adversely affects their wear performance and generates significantly higher wear rates and levels of metal ions than in as-cast metal implants.
The timing of total hip replacement (THR) in
patients with active tuberculosis (TB) of the hip is controversial, because
of the potential risk of reactivation of infection. There is little
information about the outcome of THR in these patients. We conducted
a systematic review of published studies that evaluated the outcome
of THR in patients with active TB of the hip. A review of multiple
databases referenced articles published between 1950 and 2012. A
total of six articles were identified, comprising 65 patients. TB
was confirmed histologically in all patients. The mean follow-up
was 53.2 months (24 to 108). Antituberculosis treatment continued
post-operatively for between six and 15 months, after debridement
and THR. One non-compliant patient had reactivation of infection.
At the final follow-up the mean Harris hip score was 91.7 (56 to
98). We conclude that THR in patients with active TB of the hip
is a safe procedure, providing symptomatic relief and functional
improvement if undertaken in association with extensive debridement
and appropriate antituberculosis treatment. Cite this article:
The development of tibiofemoral angle in children has shown ethnic
variations. However this data is unavailable for our population. We measured the tibiofemoral angle (TFA) and intercondylar and
intermalleolar distances in 360 children aged between two and 18
years, dividing them into six interrupted age group intervals: two
to three years; five to six years; eight to nine years; 11 to 12
years; 14 to 15Â years; and 17 to 18 years. Each age group comprised
30 boys and 30 girls. Other variables recorded included standing
height, sitting height, weight, thigh length, leg length and length
of the lower limb.Objectives
Methods
The April 2013 Spine Roundup360 looks at: smuggling spinal implants; local bone graft and PLIF; predicting disability with slipped discs; mortality and spinal surgery; spondyloarthropathy; brachytherapy; and fibrin mesh and BMP.
There have been several studies examining the
association between the morphological characteristics seen in acetabular
dysplasia and the incidence of the osteoarthritis (OA). However, most studies focus mainly on acetabular morphological
analysis, and few studies have scrutinised the effect of femoral
morphology. In this study we enrolled 36 patients with bilateral
acetabular dysplasia and early or mid-stage OA in one hip and no
OA in the contralateral hip. CT scans were performed from the iliac
crest to 2 cm inferior to the tibial tuberosity, and the morphological
characteristics of both acetabulum and femur were studied. In addition, 200 hips in 100 healthy volunteer Chinese adults
formed a control group. The results showed that the dysplastic group
with OA had a significantly larger femoral neck anteversion and
a significantly shorter abductor lever arm than both the dysplastic
group without OA and the controls. Femoral neck anteversion had
a significant negative correlation with the length of the abductor
lever arm and we conclude that it may contribute to the development
of OA in dysplastic hips. Cite this article:
The June 2012 Spine Roundup360 looks at: back pain; spinal fusion for tuberculosis; anatomical course of the recurrent laryngeal nerve; groin pain with normal imaging; the herniated intervertebral disc; obesity’s effect on the spine; the medicolegal risks of cauda equina syndrome; and intravenous lidocaine use and failed back surgery syndrome.
It is difficult to determine the safe timing
of weight-bearing or reconstructive surgery in patients with Charcot arthropathy
of the foot and ankle. In this study the Doppler spectrum of the
first dorsal metatarsal artery was used to monitor the activity
of the disease activity and served as a guideline for management.
A total of 15 patients (seven men and eight women) with acute diabetic
Charcot arthropathy of the foot and ankle were immobilised in a non-weight-bearing
cast. They were followed at two-week intervals and bilateral Doppler
spectra of the first dorsal metatarsal arteries were obtained using
a 10 MHz linear ultrasound probe. The patients were allowed to start weight-bearing
or undergo surgery after the Doppler spectrum had returned to normal
pattern. The Doppler spectra in the unaffected limbs were triphasic
in pattern, whereas those in limbs with active Charcot arthropathy
showed monophasic forward flow. They returned to normal after a
mean of 13.6 weeks (6 to 20) of immobilisation. Three patients underwent
pan-talar arthrodesis to correct gross instability and deformity. Doppler spectrum analysis of the foot may reflect the activity
of the disease in patients with Charcot arthropathy, and may be
used as a guide to begin weight-bearing or undergo reconstructive
surgery.
We conducted a prospective follow-up MRI study
of originally asymptomatic healthy subjects to clarify the development
of Modic changes in the cervical spine over a ten-year period and
to identify related factors. Previously, 497 asymptomatic healthy
volunteers with no history of cervical trauma or surgery underwent
MRI. Of these, 223 underwent a second MRI at a mean follow-up of
11.6 years (10 to 12.7). These 223 subjects comprised 133 men and 100
women with a mean age at second MRI of 50.5 years (23 to 83). Modic
changes were classified as not present and types 1 to 3. Changes
in Modic types over time and relationships between Modic changes
and progression of degeneration of the disc or clinical symptoms
were evaluated. A total of 31 subjects (13.9%) showed Modic changes at
follow-up: type 1 in nine, type 2 in 18, type 3 in two, and types In the cervical spine over a ten-year period