The three-dimensional architecture of bovine articular cartilage
We have studied the formation of
1. Experimental arthritis was induced in rats by the intradermal injection of modified Freund's adjuvant. 2. The granulation tissue occurring in and around the joints was examined with the electron microscope. 3. Intracellular
1. The utilisation of labelled proline in normal and injured mature rabbit articular cartilage has been studied and compared simultaneously in one phase of the study with radiosulphate utilisation. The morphologic features of lacerative injury paralleled those reported previously. 2. Labelled proline is actively utilised by mature articular cartilage and can be recovered in time from the matrix as labelled hydroxyproline. This is taken as evidence of
Specific antisera to
We compared the changes in the ratio of type-I and type-II
The role of three genetically distinct
In an attempt to repair articular cartilage, allograft articular chondrocytes embedded in
1. Serial slices of articular cartilage obtained at necropsy from apparently normal femoral condyles of individuals between the ages of twenty-six and sixty were examined chemically, by electron microscopy and for permeability. 2. The most superficial layer was shown by chemical analysis and electron microscopy to have the highest
We have developed a novel, two-layered,
We have examined the process of fusion of the intertransverse processes and bone graft in the rabbit by in situ hybridisation and evaluated the spatial and temporal expression of genes encoding pro-α1 (I)
The long flexor tendons of the second, third and fourth toes of 94 chickens were cut and sutured. After operation the birds were divided into three groups. To reduce peritendinous adhesions, an aqueous solution of beta-aminopropionitrile (BAPN) was added to a solution of enriched native
Autologous chondrocyte implantation (ACI) is a technique used for the treatment of symptomatic osteochondral defects of the knee. A variation of the original periosteum membrane technique is the matrix-induced autologous chondrocyte implantation (MACI) technique. The MACI membrane consists of a porcine type-I/III
Damage to the cartilage of the distal radioulnar
joint frequently leads to pain and limitation of movement, therefore repair
of this joint cartilage would be highly desirable. The purpose of
this study was to investigate the fixation of scaffold in cartilage
defects of this joint as part of matrix-assisted regenerative autologous
cartilage techniques. Two techniques of fixation of
1. The arrangement of
Two
Several bisphosphonates are now available for the treatment of osteoporosis. Porous hydroxyapatite/
Matrix-induced autologous chondrocyte implantation
(MACI) is an established technique used to treat osteochondral lesions
in the knee. For larger osteochondral lesions (>
5 cm. 2. )
deeper than approximately 8 mm we have combined the use of two MACI
membranes with impaction grafting of the subchondral bone. We report
our results of 14 patients who underwent the ‘bilayer
The presence of the connective tissue components fibronectin and the different types of