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The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 12 | Pages 1719 - 1719
1 Dec 2010
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 1 | Pages 186 - 186
1 Jan 2010
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 11 | Pages 1414 - 1421
1 Nov 2008
Arya AP Klenerman L

The Jaipur foot was developed for barefoot amputees by Professor P. K. Sethi. He used local artisans and readily available materials. The prosthesis was cheap and could be made in one hour. It enabled amputees to work in rural conditions, muddy and wet fields and to climb trees. It has been widely used in India, South East Asia and Africa, where local variations to the design have now been made.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 12 | Pages 1676 - 1676
1 Dec 2007
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 10 | Pages 1280 - 1282
1 Oct 2007
Klenerman L

This paper describes how we came to understand the pathophysiology of Volkmann’s ischaemic contracture with references to relevant papers in this Journal, and the investigation and management of acute compartment syndrome is briefly discussed.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 5 | Pages 667 - 670
1 May 2007
Klenerman L

Osteomyelitis is one of the oldest diseases known. It took many years before the acute infection could be brought under control with antibiotics and chronic osteomyelitis remains difficult to manage. The modern history of the disease is reflected in the pages of the


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 4 | Pages 545 - 547
1 Apr 2007
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 4 | Pages 623 - 623
1 May 2004
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 1 | Pages 152 - 153
1 Jan 2004
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 1 | Pages 152 - 152
1 Jan 2004
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 85-B, Issue 5 | Pages 778 - 779
1 Jul 2003
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 8 | Pages 1189 - 1193
1 Nov 2002
Bushell AJ Klenerman L Davies H Grierson I McArdle A Jackson MJ

We have previously shown that prior exposure of rat hind limbs to ischaemia for five minutes and reperfusion for five minutes reduced the structural damage to skeletal muscle which followed a subsequent period of ischaemia for four hours and reperfusion for one hour. We have now examined the potential mechanisms by which this ischaemic preconditioning protocol may be effective in reducing damage to skeletal muscle induced by prolonged ischaemia and reperfusion. Prior exposure of the hindlimb to ischaemia for five minutes and reperfusion for five minutes did not prevent the fall in the ATP content of tibialis anterior which occurred after a subsequent period of ischaemia for four hours and reperfusion for one hour. Similarly, no effect of the preconditioning protocol was seen on the elevated muscle myeloperoxidase, indicative of an elevated neutrophil content, or abnormal muscle cation content. Reperfused ischaemic muscle was also found to have an increased content of heat-shock protein (HSP) 72, but the preconditioning protocol did not further increase the content of this or other HSPs indicating that it was not acting by increasing the expression of these cytoprotective proteins. The protective effects of preconditioning appeared to be mimicked by the infusion of adenosine to animals immediately before exposure to the four-hour period, indicating a potential mechanism by which skeletal muscle may be preconditioned to maintain structural viability.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 8 | Pages 1184 - 1188
1 Nov 2002
Bushell AJ Klenerman L Taylor S Davies H Grierson I Helliwell TR Jackson MJ

Ischaemic preconditioning is a process by which exposure of a tissue to a short period of non-damaging ischaemic stress leads to resistance to the deleterious effects of a subsequent prolonged ischaemic stress. It has been extensively described in the heart, but few studies have examined the possibility that it can occur in skeletal muscle. We have used a rat model of ischaemia of one limb to examine this possibility. Exposure of the hind limb to a period of ischaemia of five minutes and reperfusion for five minutes significantly protected the tibialis anterior muscle against the structural damage induced by a subsequent period of limb ischaemia for four hours and reperfusion for one hour. This protection was evident on examination of the muscle by both light and electron microscopy. Longer or shorter times of prior ischaemia had no effect.


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 7 | Pages 1090 - 1090
1 Sep 2002
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 84-B, Issue 1 | Pages 152 - 152
1 Jan 2002
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 5 | Pages 775 - 777
1 Jul 2001
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 2 | Pages 311 - 311
1 Mar 2001
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 1 | Pages 154 - 154
1 Jan 2001
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 82-B, Issue 8 | Pages 1208 - 1208
1 Nov 2000
Klenerman L


The Journal of Bone & Joint Surgery British Volume
Vol. 82-B, Issue 8 | Pages 1208 - 1208
1 Nov 2000
Klenerman L