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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 16 - 16
1 Mar 2012
Rout R Mcdonnell SM Jayadev C Xia Z Murray D Hulley PA Price AJ
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Aim

This aim of this study was to investigate apoptosis, reactive oxygen species (ROS), and their upstream markers in Anteromedial Gonarthrosis (AMG).

Methods

Ten resection specimens, from patients undergoing unicompartmental knee replacement for AMG, and ten control specimens, collected from vascular disease patients undergoing above knee amputation, were used. Routine histology and immunohistochemical studies were conducted for Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), Active Caspase 3, Cytochrome C, Active Bax, Bim, 3-Nitrotyrosine and Forkhead box O3A (FOXO 3A).