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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_17 | Pages 73 - 73
24 Nov 2023
GENOME-BASED ANALYSIS OF VIRULENCE FACTORS OF THE GENUS CUTIBACTERIUM ISOLATED FROM IMPLANT-ASSOCIATED INFECTIONS IN SLOVENIA
Erbeznik A Šturm AC Smrdel KS Triglav T Vodicar PM
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Aim

The aim of our study was to analyze putative genes for virulence factors of Cutibacterium isolates obtained from implant-associated infections.

Methods

We analyzed 64 isolates of Cutibacterium spp. (C. acnes (53/64), C. avidum (6/64), C. granulosum (4/64), C. namnetense (1/64)) using NextSeq 550 (Illumina, San Diego, CA, USA) and performed genomic analysis of 24 genes associated with virulence factors (VFs) of C. acnes previously reported in the literature. Most isolates were obtained from implant-associated infections (IAI) between 2012–2021 at the Institute of Microbiology and Immunology, Faculty of Medicine, Ljubljana. Additionally, we included the first C. namnetense isolated in our laboratory from surgical site infection.