Purpose: Traditionally, the accepted treatments for adolescent idiopathic scoliosis (AIS) have included open anterior thoracotomy with instrumentation and posterior spinal fusion and instrumentation. Thoracoscopic instrumentation is a newer technique, whose role remains controversial. This systematic review of the literature aims to better understand thoracoscopic instrumentation as a treatment for AIS and to discuss it in the context of the alternative techniques currently used.

Method: The most commonly used medical databases (PUBMED, Medline, EMBASE, Cinahl, and the Cochrane library) were searched up to April 2008 using the search terms “VATS”, “thoracoscopic scoliosis” and “thoracoscopic scoliosis instrumentation”. Two reviewers independently performed the literature evaluation. There were no language restrictions. Because the number of randomized controlled trials was anticipared to be small, we included relevant non-randomized trials, observational studies, and uncontrolled studies.

Results: Eleven studies met the strict inclusion criteria for the systematic review, of which the majority were level III and IV evidence. Four hundred and forty-five cases have been reported, 80% of them female, with the vast majority having a diagnosis of AIS. Similar surgical techniques were used and had a mean operative time of 355 minutes, mean blood loss of 444 ml, and mean hospital stay of 5.1 days. Mean pre-operative curve magnitude was 47.9o; post-operative curve magnitude was 16.3o, with a correction of 62%. Number of levels instrumented was 6.3, pulmonary function testes returned to pre-operative values by 2-years post-operative, and complication rate was 21.6%, including a pulmonary complication rate of 9.2%. SRS questionnaires revealed that patients were satisfied.

Conclusion: The major drawbacks of the thoraco-scopic approach are the operative time and incidence of early pulmonary complications. Advantages include: minimally invasive, less blood loss, short hospital stay, excellent curve correction, few levels fused, good patient satisfaction, and no long term effect on pulmonary function. With appropriate surgeon training, careful patient selection, and precise surgical technique, this technique can offer an acceptable alternative to the more traditional procedures.

Purpose: The current gold standard for spinal arthrodesis, autologous bone graft harvested from the iliac crest, has several disadvantages including donor site morbidity, blood loss, delayed wound healing, and increased operative time. Our study explores a Demineralized Bone Matrix-Calcium Sulfate(DBM-CaSO4) composite graft with autologous bone marrow aspirate (BMA), and compares it to autologous iliac crest bone graft in lumbar and lumbosacral spinal fusions.

Method: A total of 80 patients were recruited for the study and randomised, via a computer-generated ran-domisation schedule, to autologous iliac crest bone graft (control) or DBM-CaSO4 composite graft with BMA (study) groups. Patients were evaluated at three-months, six-months, 12-months and 24-months post-operatively with questionnaires to evaluate clinical outcome (Oswestry disability questionnaire (ODI), visual analogue pain scales (VAS), and validated SF-36) and with posteroanterior and lateral x-rays of the spine to evaluate radiological outcome.

Results: At 24-months post-operatively, there were no statistical differences seen between the two groups based on the clinical outcomes measured. Average ODI values were 27.19 for the control group versus 22.68 for the study group (p > 0.05). The average back VAS pain for the control group was 3.50 versus 3.51 for the study group (p > 0.05). The SF-36 score was 89.22 for the control group versus 91.56 for the study group (p > 0.05). The average operative time was 115.7 minutes for the control group versus 104.2 minutes for the study group (p: 0.014). Average calculated blood loss was 571.9 cc for the control group versus 438.2 cc for the study group (p: 0.025). The Lenke score was 1.92 for the control group versus 2.66 for the study group (p: 0.004).

Conclusion: At two year follow-up, radiographic fusion was slightly higher in the ICBG. However, clinical outcomes were equivalent in both groups. Moreover, the DBM-CaSO4 and BMA composite graft offered the advantages of decreased blood loss and shorter operative time. Therefore, the DBM-CaSO4 and BMA composite graft represents a viable alternative to autologous iliac crest bone graft in carefully selected patients undergoing spinal arthrodesis.