Aim: To investigate the effectiveness of Adcon-L in re-discectomy and/or surgical neurolysis compared to autologous fat graft. Methods: A total of 50 patients with recurrent disc herniation (n=30) and/or epidural þbrosis (n=20) were included. All had failed in conservative treatment and suffered from predominantly radicular pain. MRI scans proofed the re-herniation (same segment, same side) and/or epidural þbrosis. Standard preoperative and follow-up examinations were carried out. Follow-up examination was performed by an independend investigator. Data were analysed using the intention-to-treat principle. Result: The clinical outcome showed no statistically difference between both groups one year after revision surgery. Conclusion: Due to our results, and as we know that the rate of clinically relevant cerebrospinal ßuid leakage is increased after the application of Adcon-L, we prefer the use of autologous graft as an antiadhesive in revision surgery of the spinal canal.