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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 154 - 154
1 May 2012
S. S P. K M. U
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Background

Staphylococcus epidermidis is one of the main organisms associated with prosthetic joint infections. One of the major pathogenic attributes of this organism is the ability to form biofilms, making it extremely resistant to currently available antimicrobial therapies. There is, therefore, an urgent requirement for novel agents that are effective against this organism. Antimicrobial peptides represent a novel group of agents that show good activity towards biofilm-forming S. epidermidis. Antimicrobial peptides are particularly interesting due to their multiple modes of action which are thought to reduce the rate of resistance development to the agents.

Aim

The aim of the current study was to assess the effect of antimicrobial peptides gallidermin and novel peptide NI01 on the growth of reference and clinical isolates of S. epidermidis on polymethylmethacrylate (PMMA) cement following incorporation of the peptides.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 63 - 63
1 May 2012
M. B N. S P. D S. S G.H. G E. S J. D
Full Access

Purpose

The objective of this meta-analysis was to compare the effects of early and delayed surgery on the risk of mortality, common post-operative complications, and length of hospital stay among elderly hip fracture patients.

Methods

We searched MEDLINE and EMBASE for relevant prospective studies evaluating surgical delay in patients undergoing surgery for hip fractures published in all languages between 1966 and 2008. Two reviewers independently assessed methodological quality and extracted relevant data.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 140 - 140
1 May 2012
S. H P. H H. Z M. K I. TJ S. S H. M
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Introduction

The advantage of using SPECT-CT over conventional bone scanning is that it has the promise of linking the multiplanar reconstructional images of CT with the functional analysis of bone scintigraphy. It delivers information regarding new pathology and is regarded as more sensitive and specific. We present our experience of use of the SPECT-CT in the analysis of continued or recurrent pain post-foot and ankle arthrodesis.

Methods and Materials

A retrospective analysis of all post-arthrodesis patients with continued pain who underwent SPECT-CT was carried out. The scans and notes from clinical examination were evaluated. The request for the scan was at the clinician's discretion and was reserved for presentations where the diagnosis was unclear on clinical and radiological grounds.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXI | Pages 16 - 16
1 May 2012
R. LR S. S Y. H D. S T. S J. W
Full Access

Purpose

The optimal sequencing of radiotherapy (RT) with surgery in soft-tissue sarcomas (STS) remains undefined. We assessed the impact of RT sequencing on overall survival (OS), cause-specific survival (CSS), local failure, and distant failure.

Methods

A retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumour registries owned by Impac(r) Medical Systems (Sunnyvale, CA). Eligible sites were soft tissues of the head/neck, thorax, abdomen, pelvis, extremities, trunk, and peritoneum. Only patients with known stage and grade were included. Prognostic factors were identified with multivariate analysis (MVA) using the Cox proportional hazards model. Survival was calculated using the Kaplan-Meier method, and compared for statistical significance (p< 0.05) using the log-rank test.