Unicompartmental knee replacement (UKR) is an established treatment for single compartment end-stage knee arthrosis with good recorded survivorship. Although often used in more active younger patients, patient selection remains controversial. To identify risk factors for early failure we compared patients with UKR failure requiring revision to total knee replacement (TKR) with a control group. Between September 2002 and 2008, 812 Oxford Mobile Bearing Medial UKRs were implanted. 21 implants (20 patients) required revision to TKR within 5 years. The leading cause for revision was lateral compartment disease progression (11 patients). In the revision group, 17 patients were female (81%), average age at index surgery was 64.1 (range 48-81) and average BMI 31.8 (range 24.4-41.5). In the control group of all patients who underwent UKR during this period, 348 patients were female (44%), average age was 65.0 (range 36-89) and average BMI 31.2 (range 21.0-61.0). Radiological assessment of the tibiofemoral valgus (TFV) angle for revision patients was compared with an age and sex matched control group. In the revision group, average TFV angle was +1.5 pre-operatively and +6.1 post-operatively with an average change of +4.6. In the control group average TFV angle was -0.4 pre-operatively and +4.3 post-operatively with an average change of +4.7.Background
Methods & Results
To examine measurement properties of four disability outcomes in patients with advanced osteoarthritis of the glenohumeral joint. This was a prospective longitudinal study of patients with advanced osteoarthritis of the glenohumeral joint who underwent a Total Shoulder Arthroplasty (TSA) and were followed for 6 months. Four measures [Western Ontario Osteoarthritis Shoulder (WOOS) Index, the American Shoulder and Elbow Surgeons (ASES) assessment, Constant-Murley score (CMS), and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH)] were completed 2-3 weeks before surgery and at 6 months after surgery.Purpose
Methods
The process of osteolysis is well studied both in vivo and in vitro. Although multiple pathways have been implicated in osteolytic change and animal models have been developed there are few human tissue studies. There are no extensive human tissue studies comparing osteoarthritic hips to well fixed and loose prostheses. We have investigated 96 genes previously implicated in the osteolytic pathway. Genes were included based on previous implication in osteolysis in basic science studies. Candidates included cytokines, growth factors, apoptotic factors, matrix proteinases, interleukins, apoptotic proteins and macrophage activators.Background
Methods
