Radiolucencies are generally thought to be a manifestation of loosening. They are commonly seen under the tibial component of the Oxford Unicompartmental knee replacement. However, they are not associated with long term failure [ Eight medial Oxford Unicompartmental knee prostheses were examined post-operatively, at 12 months and at 24 months using Roentgen Stereophotogrammetric Analysis (RSA). The serial radiographs were calibrated and three dimensional CAD models were matched to the extracted component shapes. Implanted bone marker balls were then selected on all radiographs. The components were superimposed. Migration calculation was achieved by comparing relative positions of components to bone marker balls in the serial radiographs. Fluoroscopically screened X-rays were taken to determine whether there were any radiolu-cencies under the tibial component. By 12 months, the femoral component had migrated significantly anteriorly (0.35 mm) and proximally (0.61 mm). The tibial component had migrated significantly distally (0.42 mm) and anteriorly (0.47 mm). Although on average there appeared to be a small further migration between 12 and 24 months, this was not statistically significant in any direction. Six of the eight patients had radiolucencies at 24 months. None of the radiolucencies were was complete. The maximum radiolucency was 1 mm thick and the average was 0.57 mm. There was no correlation between radiolucency and migration. The proximal femoral migration and distal tibial migration can be explained by the load across the knee. We cannot yet explain the anterior tibial migration. Radiolucencies almost always occur and are not related to migration.This confirms they are not associated with loosening.