The aim was to investigate whether or not the pre-operative injection of cortico-steroids into the knee influences the infection rate of a subsequent total knee replacement. This was a case controlled study, in which it was calculated that 152 controls and 38 infected cases would give sufficient power to the study. The infection group had to have had a delay in wound healing or have had a revision for infection. A total of 32.8% had had an injection at some time pre-operatively. The average number of injections was 2.23, with a range of 1–15. 37% were performed by a G.P., 35% by an orthopaedic surgeon, and 22% by a rheumatologist.79% had the injection within 12 months of surgery. The rate of injection was the same in the two groups. There was no significant difference in the infection rate between the two groups (OR 1.38; 95%CI 0.55–3.31) Despite recent literature indicating that there is a 10% increase in infection in patients having steroid injections into the hip prior to THR this study does not confirm this risk in patients undergoing TKR.
To assess if highly cross-linked polyethylene is associated with less linear wear than ultra high molecular weight polyethylene in vivo. To assess whether alteration in biomechanical characteristics of the reconstructed hip influence’s wear patterns. A randomised prospective trial comparing conventional polyethylene with highly cross-linked polyethylene in an acetabular component was designed. Identical cemented stems were used in all cases, with a metal head. The polyethylene thickness was controlled. The trial design required 124 cases to be entered to give the study sufficient power to determine any difference in wear rates. Polyware Auto was used to assess 2D wear rate and volume. This paper presents the preliminary results of the early patients entered into the study and looks at both 2D wear or creep at 18 months post operatively, and seeks to establish any relationships between 2D movement and biomechanical characteristics of the reconstructed hip. There was no significant difference in the 2D wear (or creep) between the two types of polyethylene at 18 months. There was no correlation between femoral offset, cup offset, or centre of rotation offset and 2D wear (or creep). This preliminary data shows no difference in the early wear rate of the two types of polyethylene. This is in contrast to an in vitro wear simulator study that has shown more creep in highly cross-linked polyethylene. The significance of this observation is unclear. We hope to demonstrate that as the trial progresses any difference in the performance of the two types of polyethylene should be evident.