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Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_19 | Pages 14 - 14
22 Nov 2024
IN VITRO STUDY ON CHEMICAL DEBRIDEMENT DURING PERIPROSTHETIC JOINT INFECTION SURGERY: WHAT IS THE BEST TREATMENT STRATEGY?
Gómez MM Guembe M Díaz-Navarro M Peinado LP Matas-Díaz J Ruiz PS
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Aim

Chemical debridement is a fundamental step during Periprosthetic joint infection (PJI) surgery. Antiseptic solutions are commonly used, but evidence on the optimal antiseptic, concentration, and irrigation time is lacking. The aim of this study is to analyze and compare the anti-biofilm capacity of povidone iodine, H202, acetic acid and Bactisure™ after different exposure times, as well as their combinations.

Method

Surgical steel discs inoculated with methicillin susceptible (MSSA) and resistant S. aureus (MRSA), P. aeruginosa, and S. epidermidis were exposed to the following antiseptic solutions: 0.3% (PI0.3) and 10% povidone iodine (PI10), H202, 3% Acetic acid (AA3) and Bactisure™. Combinations included AA3, H202, and PI10 in various orders. Exposure time for the antiseptics solutions was 1, 3 and 5 minutes, while combinations had a 9-minute total exposure, 3 minutes per antiseptic sequentially. All experiments were performed in triplicate and with a sterile saline control. nThe reduction in colony-forming units (CFU) was measured after sonication, and biofilm structure was analyzed via scanning electron microscopy.

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