Inflammation and chemokines play a pivotal role in aseptic loosening (AL) and prosthetic joint infection (PJI) of total joint arthroplasty (TJA). Recently, the Duffy antigen receptor for chemokines (DARC) on erythrocytes was identified as a potent chemokine receptor able to bind and carry without deactivating a wide range of CXC and CC chemokines from circulation to tissues. The role of DARC and its functional polymorphism (SNP) influencing the number of the DARC molecules on the erythrocytes in AL/PJI has not been studied yet. We genotyped functional polymorphism in the DARC gene (rs12075) using MassArray technology (Agena Bioscience) in 354 patients with TJA (hip and knee arthroplasties). Patients were further subdivided into those with a complication (AL, n = 110; PJI, n = 126) and a control group without complications for at least 10 years (n = 118). Statistics was performed by Plink 1.07 and relative entropy.Background
Methods
We performed in 1998–2003 in our Orthopedic clinic-nearly 3800 hip arthroplasties, nearly 650 of them S-ROM System (includingrevision surgery). The aim of these paper is to introduce our experience inhip arthroplasty in specific anatomic conditions with Modular S-ROM System. We examined in a retrospective study 42 patients, operated in 1998/1999, with follow up of 37 months. It was by all of these patients because of specific anatomic conditions (CDH, M. Perthes, Coxaplana, St. p. osteotomy of proximal femur...) not possible or reliable to implant our standard implant and we had implanted Modular S-ROM System. We had seen intra operatively 3 femur infractions and postoperatively 1 partially is chiadicus palsy after leg lengthening of 3,5cm. The Harris hip score is in all patient improved (preoperatively on average 41,7 pts., postoperatively 85,2 pts.). We habe seen no thigh pain in our group of patients and no loosening of prothesis. We use, due to our increased positive experience in primary and also revision hip surgery in last years with-Modular S-ROM System (modularity, variability, rotational stability, good osteointegration, no fretting, no thigh pain), this System in specific anatomic conditions and in most cases of revision hip surgery, with good and reliable aerly and mid term results.
