We present the results of 15 patients revised with a Compress® prosthesis secondary to failure of other distal femur reconstruction. One prosthesis had to be removed because of deep infection. Three patients needed a second surgery due to a vertical crack proximal to the anchor plug at the level of a cortical bone defect. At last follow-up, radiologic evaluation of the entire series showed a mean bone growth ratio higher than did preoperative radiographs. All patients had mainly good or excellent MSTS functional results. Distal femoral prosthetic replacement with a Compress® implant in severe cases of bone loosening and instability provides a reliable reconstruction alternative that promotes bone formation. Patients with cortical defects proximal to the anchor plug should be protected with extracortical supports.