Aims

The objective of this study was to present the outcomes of rotational acetabular osteotomy (RAO) over a 30-year period for osteoarthritis (OA) secondary to dysplasia of the hip in pre- or early-stage OA.

Aim

Mesenchymal stem cells (MSCs) have several properties that may support their use as an early treatment option for osteoarthritis (OA). This study investigated the role of multiple injections of allogeneic bone marrow-derived stem cells (BMSCs) to alleviate the progression of osteoarthritic changes in the various structures of the mature rabbit knee in an anterior cruciate ligament (ACL)-deficient OA model.

Aims

The aim of this study was to report the long-term results of rotational acetabular osteotomy (RAO) for symptomatic hip dysplasia in patients aged younger than 21 years at the time of surgery.

Aims

To investigate the risk factors for progression of articular cartilage damage after anatomical anterior cruciate ligament (ACL) reconstruction.

Aims

Our aim was to evaluate the radiographic characteristics of patients undergoing total hip arthroplasty (THA) for the potential of posterior bony impingement using CT simulations.

Objectives

The objective of this study was to investigate the therapeutic effect of peripheral blood mononuclear cells (PBMNCs) treated with quality and quantity control culture (QQ-culture) to expand and fortify angiogenic cells on the acceleration of fracture healing.

Objectives

Regenerative medicine is an emerging field aimed at the repair and regeneration of various tissues. To this end, cytokines (CKs), growth factors (GFs), and stem/progenitor cells have been applied in this field. However, obtaining and preparing these candidates requires invasive, costly, and time-consuming procedures. We hypothesised that skeletal muscle could be a favorable candidate tissue for the concept of a point-of-care approach. The purpose of this study was to characterize and confirm the biological potential of skeletal muscle supernatant for use in regenerative medicine.

Background

The clinical results of total hip arthroplasty (THA) with a cementless prosthesis have been constantly improving due to progress in the area of stem design and surface finish. However, majority of stems are well-fixed with canal filling or diaphyseal fit, and cortical hypertrophy or metaphyseal bone atrophy has been often observed. Cementless Spotorno stem (CLS stem; Zimmer, Warsaw, USA) is a double-tapered rectangular straight stem. The purpose of this study is to investigate the mean 13 years' results of CLS stem and to evaluate the press-fit stability of CLS stem.

Introduction

Clione Anchored Replacement Prosthesis (CARP-H system) is a novel femoral implant for cementless fixation at the metaphysis of the proximal femur and preservation of cancellous bone of the femoral diaphysis is expected (Fig.1). We developed CARP-H system and started to use the prosthesis after the approval by Pharmaceuticals and Medical Devices Agency in 2012. This study examines the efficacy and short-term outcome of CARP-H system in a series of patients undergoing total hip arthroplasty (THA) or bipolar hemi-arthroplasty (BHA).

We report the clinical outcome and findings at second-look arthroscopy of 216 patients (mean age 25 years (11 to 58)) who underwent anterior cruciate ligament (ACL) reconstruction or augmentation. There were 73 single-bundle ACL augmentations (44 female, 29 male), 82 double-bundle ACL reconstructions (35 female, 47 male), and 61 single-bundle ACL reconstructions (34 female, 27 male).

In 94 of the 216 patients, proprioceptive function of the knee was evaluated before and 12 months after surgery using the threshold to detect passive motion test.

Second-look arthroscopy showed significantly better synovial coverage of the graft in the augmentation group (good: 60 (82%), fair: 10 (14%), poor: 3 (4%)) than in the other groups (p = 0.039). The mean side-to-side difference measured with a KT-2000 arthrometer was 0.4 mm (-3.3 to 2.9) in the augmentation group, 0.9 mm (-3.2 to 3.5) in the double-bundle group, and 1.3 mm (-2.7 to 3.9) in the single-bundle group: the result differed significantly between the augmentation and single-bundle groups (p = 0 .013). No significant difference in the Lysholm score or pivot-shift test was seen between the three groups (p = 0.09 and 0.65, respectively). In patients with good synovial coverage, three of the four measurements used revealed significant improvement in proprioceptive function (p = 0.177, 0.020, 0.034, and 0.026).

We conclude that ACL augmentation is a reasonable treatment option for patients with favourable ACL remnants.

Cite this article: Bone Joint J 2014;96-B:1325–32

Summary Statement

We evaluated the mechanical strength of two cortical suspension devices by reproducing clinical situation for ACL reconstruction. A most important factor affecting the displacement during cyclic load was the length of the tendon rather than the length of the device.

In Japan, osteoarthritis (OA) of the hip secondary to acetabular dysplasia is very common, and there are few data concerning the pathogeneses and incidence of femoroacetabular impingement (FAI). We have attempted to clarify the radiological prevalence of painful FAI in a cohort of Japanese patients and to investigate the radiological findings. We identified 176 symptomatic patients (202 hips) with Tönnis grade 0 or 1 osteoarthritis, whom we prospectively studied between August 2011 and July 2012. There were 61 men (65 hips) and 115 women (137 hips) with a mean age of 51.8 years (11 to 83). Radiological analyses included the α-angle, centre–edge angle, cross-over sign, pistol grip deformity and femoral head neck ratio. Of the 202 hips, 79 (39.1%) had acetabular dysplasia, while 80 hips (39.6%) had no known aetiology. We found evidence of FAI in 60 hips (29.7%). Radiological FAI findings associated with cam deformity were the most common. There was a significant relationship between the pistol grip deformity and both the α-angle (p < 0.001) and femoral head–neck ratio (p = 0.024). Radiological evidence of symptomatic FAI was not uncommon in these Japanese patients.

Cite this article: Bone Joint J 2013;96-B:172–6.

For the treatment of ununited fractures, we developed a system of delivering magnetic labelled mesenchymal stromal cells (MSCs) using an extracorporeal magnetic device. In this study, we transplanted ferucarbotran-labelled and luciferase-positive bone marrow-derived MSCs into a non-healing femoral fracture rat model in the presence of a magnetic field. The biological fate of the transplanted MSCs was observed using luciferase-based bioluminescence imaging and we found that the number of MSC derived photons increased from day one to day three and thereafter decreased over time. The magnetic cell delivery system induced the accumulation of photons at the fracture site, while also retaining higher photon intensity from day three to week four. Furthermore, radiological and histological findings suggested improved callus formation and endochondral ossification. We therefore believe that this delivery system may be a promising option for bone regeneration.

Introduction

Since 2005, we have performed implantation of bone marrow-derived mononuclear cells for osteonecrosis of the femoral head in order to improve vascularization and bone repair. This study focused on early bone repair of osteonecrosis of the femoral head after transplantation of bone marrow-derived mononuclear cells (BMMNC).

We examined whether enamel matrix derivative (EMD) could improve healing of the tendon–bone interface following reconstruction of the anterior cruciate ligament (ACL) using a hamstring tendon in a rat model. ACL reconstruction was performed in both knees of 30 Sprague-Dawley rats using the flexor digitorum tendon. The effect of commercially available EMD (EMDOGAIN), a preparation of matrix proteins from developing porcine teeth, was evaluated. In the left knee joint the space around the tendon–bone interface was filled with 40 µl of EMD mixed with propylene glycol alginate (PGA). In the right knee joint PGA alone was used. The ligament reconstructions were evaluated histologically and biomechanically at four, eight and 12 weeks (n = 5 at each time point). At eight weeks, EMD had induced a significant increase in collagen fibres connecting to bone at the tendon–bone interface (p = 0.047), whereas the control group had few fibres and the tendon–bone interface was composed of cellular and vascular fibrous tissues. At both eight and 12 weeks, the mean load to failure in the treated specimens was higher than in the controls (p = 0.009). EMD improved histological tendon–bone healing at eight weeks and biomechanical healing at both eight and 12 weeks. EMD might therefore have a human application to enhance tendon–bone repair in ACL reconstruction.

Background: A retroverted acetabulum has been hypothesized as a cause of osteoarthritis. This study was performed to evaluate whether radiographical cross-over sign influence the painful femoro-acetabular impingement or the radiographical progression of osteoarhritis after rotational acetabular osteotomy (RAO) for dysplastic hip.

Methods: Between 1987 and 1999, 104 patients (115 hips) who had pre- or early stage osteoarthritis of the hip due to dysplasia underwent a RAO. There were 99 women and five men; their mean age at the time of surgery was 34.7 years. The mean follow-up period was 13 years. Clinical follow-up was performed with use of the system of Merle d’Aubigne and the impingement sign was evaluated. Radiographical analyses included measurements of the center-edge angle, acetabular roof angle, head lateralization index, joint congruency, cross-over sign, posterior wall sign, acetabular index of depth to width, pistol grip deformity and femoral head-femoral neck ratio.

Results: The mean clinical score improved significantly from 14.6 preoperatively to 17.0 at follow-up. The impingement sign at the follow-up was observed in 14 hips (12.2%). The center-edge angle improved significantly from mean −0.6 degrees to a postoperative mean of 34 degrees. The acetabular roof angle improved from 30 degrees to 2.2 degrees, and head lateralization index from 0.64 to 0.60. The cross-over sign was observed in 8 hips (7.0%) preoperatively and in 49 hips (42.6%) postoperatively. The posterior wall sign was observed in 70 hips (60.9%) preoperatively and observed in 73 hips (63.5%) postoperatively. The mean preoperative acetabular index of depth to width was 35.5% and the mean preoperative femoral head to femoral neck ratio was 1.49. The pistol grip deformity was observed in only 4 hips (3.5%) preoperatively. The impingement sign after the RAO was positive significantly in the postoperative cross-over sign positive hips (p=0.0074). Radiographical progression of osteoarthritis was observed in 11 hips (cross over sign positive; 7 hips, cross over sign negative; 4 hips). The Kaplan-Meier survivorship analysis predicted a survival rate of 84.6 % at 15 years. The only factors significantly associated with radiographic signs of progression of osteoarthritis after RAO were fair (rather than excellent and good) postoperative joint congruency (p< 0.0001) and age at surgery (p=0.0042). Presence of postoperative cross-over sign had no effect on the outcome (p=0.2073).

Conclusions: Although there was no significant radiographical progression of osteoarthritis despite a significant retroversion in most cases, the goal of RAO should be a correct alignment of the acetabulum including a correct version with a negative cross-over sign.

The transfer of part of the ulnar nerve to the musculocutaneous nerve, first described by Oberlin, can restore flexion of the elbow following brachial plexus injury. In this study we evaluated the additional benefits and effectiveness of quantitative electrodiagnosis to select a donor fascicle. Eight patients who had undergone transfer of a simple fascicle of the ulnar nerve to the motor branch of the musculocutaneous nerve were evaluated. In two early patients electrodiagnosis had not been used. In the remaining six patients, however, all fascicles of the ulnar nerve were separated and electrodiagnosis was performed after stimulation with a commercially available electromyographic system. In these procedures, recording electrodes were placed in flexor carpi ulnaris and the first dorsal interosseous. A single fascicle in the flexor carpi ulnaris in which a high amplitude had been recorded was selected as a donor and transferred to the musculocutaneous nerve. In the two patients who had not undergone electrodiagnosis, the recovery of biceps proved insufficient for normal use. Conversely, in the six patients in whom quantitative electrodiagnosis was used, elbow flexion recovered to an M4 level.

Quantitative intra-operative electrodiagnosis is an effective method of selecting a favourable donor fascicle during the Oberlin procedure. Moreover, fascicles showing a high-amplitude in reading flexor carpi ulnaris are donor nerves that can restore normal elbow flexion without intrinsic loss.

We used interconnected porous calcium hydroxyapatite ceramic to bridge a rabbit ulnar defect. Two weeks after inducing the defect we percutaneously injected rabbit bone marrow-derived mesenchymal stromal cells labelled with ferumoxide. The contribution of an external magnetic targeting system to attract these cells into the ceramic and their effect on subsequent bone formation were evaluated.

This technique significantly facilitated the infiltration of ferumoxide-labelled cells into ceramic and significantly contributed to the enhancement of bone formation even in the chronic phase. As such, it is potentially of clinical use to treat fractures, bone defects, delayed union and nonunion.

The purpose of this study was to elucidate the hemostatic effects of tranexamic acid (TA) in patients undergoing total knee arthroplasty (TKA) performed with different three methods.

The subjects were 89 patients (10 males, 79 females; mean age at surgery 74 years old) who underwent TKA for osteoarthritic knees in our department between April 2006 and October 2007. A cemented prosthesis (NexGen LPS flex, Zimmer) was used in all cases. The subjects were divided into three groups; Group A (n=39), in whom intravenous administration of TA (1 000 mg) 15 minutes before tourniquet release and a drain-clamping method [DC; joint filled with 50 ml of fluid that contained TA (1 000 mg, 10 ml) and 40 ml of physiological saline just after surgery] were performed, as reported by Prof. Otani (Keio Univ., Tokyo, Japan) in 2005; Group B (n=20), who had the same protocol as Group A, except that the DC Joint was filled with a total of 50 ml physiological saline alone; and group C (n=30), who received DC alone with 50 ml of physiological saline and no intravenous administration of TA. The parameters evaluated were the amounts of intra-operative bleeding, bleeding after 24 hours, total bleeding (intra- and post-operative), and changes in Hb levels between before surgery and 1 week after surgery. Statistical analyses were performed using a Mann-Whitney U-test, with P-values greater than 0.05 considered to be significant.

No differences were observed in the amount of bleeding during the TKA among the groups. In contrast, bleeding at 24 hours after surgery and total amounts of bleeding were significantly lower in Group A (281 and 695ml, respectively) as compared to Group B (337 and 868 ml, respectively) and Group C (650 and 1043 ml, respectively) (p< 0.01). In addition, Hb levels at 1 week after surgery were reduced by 1.8 g/dl in Group A, as compared to 2.3 and 3.0 g/dl in Groups B and C, respectively, demonstrating a significantly lower amount of reduction in Group A (p< 0.01).

The effect of TA for reducing blood loss in TKA is widely recognized. In the present study, concomitant use of an intravenous administration and infiltration into the joint (via DC) significantly reduced blood loss during and after TKA. Furthermore, allogenic blood transfusion could be avoided in all patients (Group A) who underwent that protocol. In our study, even when given intra-operatively, such as intravenous administration and infiltration, there were no complications. Nevertheless, when used during the post-operative course, careful attention should be paid to prevent such problems. In order to reduce blood loss during and after TKA, it is important to elucidate the optimal conditions, volume, and timing of administration of TA in future studies.

This study was conducted to investigate the cases which were obliged to receive revision surgery within the first 5 years after primary Total Knee Arthroplasty (TKA).

The subjects of this study were 15 patients (5 males & 10 females, mean age at revision 72 years) who had undertaken revision surgery within 5 years since 1996. Intervals between primary and revision TKA averaged 29.8 months. Prosthesis used for primary TKA was as follows; 11 Zimmer NexGen LPS-flex fixed bearing, 2 mobile bearing, 2 CR type.

Revised components, cause of revision, JOA score as clinical results and FTA as radiographic evaluation were examined.

Revised parts were as follows;

All components: 2,

Stemmed Femoral components were used in 6 out of 8 knees, stemmed Tibial components in 9 out of 11 knees.

The causes of revision were as follows;

infection: 1,

JOA scores improved from 45 points to 78 points, and FTA proved to be 176 deg., postoperatively.

Primary TKA remains one of the most successful orthopedic procedures. Survivorship was generally reported over 15 years in the previous article. However, there are some cases in which revision TKA is necessary by some causes. There seems to be various types of causes for revisions, such as loosening, inadequate position, abrasion of components and others. Though loosening of components due to traumatic cause was inevitable, other causes, such as inadequate position of component, imbalanced soft tissues and infection, which depend on our technique, should be cared during and after surgery. From our study, except for 7 (2 trauma, 5 unknown) out of 15 knees, almost half of revision TKA (8 knees) might be due to technical demand. As for surgical techniques, in the case of poor bony quality, we routinely use stemmed components and should try not to impact strongly on setting component to prevent from sinking. In the case of non-traumatic cause, 3 out of 12, though the position of tibial component was acceptable, tibial component sunk because of bony weakness and/or imbalanced soft tissues resulting pain.

Adequate position and balance of components should be achieved during primary TKA. In our department, we are trying to revise and routinely use stemmed components as soon as possible, when loosening of component is confirmed. Metal augmentation, if necessary, is mainly used for bone defect to do early rehabilitation.

We concluded that adequate position of components and soft tissue balance was very important at the time of primary TKA. Clinical results of revision TKA were almost equal to those of primary TKA, however, long term follow-up will be needed.