Aims: To compare the vastus muscle-splitting approach and the classical medial parapatellar in total knee replacement. Methods: Prospective clinical and radiographic study in 50 cemented cruciate-retaining prostheses (Interax, Stryker-Howmedica-Osteonics): midvastus approach in 25 and parapatellar medial in 25. Results: There were no differences (p> 0.05) in postoperative femoro-tibial or patelar tilt angles, duration of surgery, drainage bleeding, Hemoglobine and Hematocrite at postoperative day 3, units of blood transfused, complications, hospital stay, range of motion, and score of the American Knee Society at 1, 6, 12 or 24 months. However, the midvastus approach showed less intraoperative lateral retinacular releases, more patients were able to get independent terminal knee extension at postoperative day 5, and the range of motion at discharge was higher (p< 0.05). Conclusions: The midvastus splitting approach can reduce the need to perform lateral retinacular releases, with advantages in the early postoperative range of motion and knee extension ability.