The anatomy of the prevertebral region of the neck is of vital importance to orthopaedic surgeons when managing cervical spine trauma. Lateral radiographs are used in the acute assessment of this area as they are readily available and cost effectiveness. Thickening of the retropharyngeal space on a radiograph may be highly suggestive of serious and life-threatening pathologies. Accurate interpretation of radiological evidence is essential to assist the clinician in diagnosis. Current guidelines for radiological measurement state that these prevertebral soft tissues should not exceed 5mm at the midvertebral level of C3 and 20mm at C7. A ratio between soft tissue measurements and the width of the corresponding vertebra has also been championed as this takes into account magnification errors and variation in patient body habitus. Soft tissue measurements greater than 30% of the upper cervical vertebral bodies and greater than 100% of the lower cervical vertebral bodies are considered to be abnormal. The aim of this study was to assess reliability of current radiological guidelines on soft tissue measurement. A review of 200 consecutive normal lateral soft tissue cervical spine radiographs was undertaken. Patients were included if they were immobilised for blunt trauma and were aged 18 or older. Each patient included had cervical pathology excluded by a combination of clinical examination, flexion-extension views, CT and or MRI. Exclusion criteria included those patients with pre-existing cervical or retropharyngeal pathology, those who had been intubated or had a nasogastric tube passed. Two reviewers independently assessed soft tissue and bony widths at C3 and C7 using the PACs Software. All measurements were taken at the mid vertebral level, not at the end plates to ensure any anterior osteophytes did not create a falsely wide measurement. Plane film radiographs of 107 males and 93 females were included with an average age of 53. At the C3 level, mean soft tissue widths were 4.7mm ± 0.84mm SD and ranged from 2.7 to 7.4mm. The mean soft tissue width at C7 was 14.4mm ± 2.8mm SD with a range of 7.1 to 21.0 mm. Our results show 21.5% (43/200) of the patients exceeded the 5mm upper limit and 20% (40/200) exceeded the soft tissue to vertebra ratio at C3. Only 1% (2/200) of patients exceeded the upper limit of 20mm at C7 and only 2% (4/200) exceeded the soft tissue to vertebra ratio. The C3 guideline for maximum soft tissue widths has a poor specificity (78.5%) and the soft tissue to vertebral ratio at this level may also lead to further unnecessary investigation, as it too has a specificity of only 80%. However, the guidelines for PVST measurements at C7 are much more reliable with a specificity of 99.5% for the absolute measurement and 99% for the soft tissue to vertebra ratio. The ratio measurement has not conferred any significant diagnostic benefit over the static measurement. Current guidelines overestimate injuries at the C3 level but seem appropriate at the C7 level. There is no major benefit to using a ratio measurement over an absolute value.