For many years, achieving a neutral coronal Hip-Knee-Ankle angle (HKA) measured on radiographs has been considered a factor of success for total knee arthroplasty (TKA). Lower limb HKA is influenced by the acquisition conditions, and static HKA (sHKA) may not be representative of the dynamic loading that occurs during gait. The primary aim of the study was to see if the sHKA is predictive of the dynamic HKA (dHKA). A secondary aim was to document to what degree the dHKA changes throughout gait. We analysed the 3-D knee kinematics during gait of a cohort of 90 healthy individuals (165 knees) with the KneeKG™ system. dHKA was calculated and compared with sHKA values. Knees were considered “Stable” if the dHKA remained positive or negative – i.e. in valgus or varus – for greater than 95% of the corresponding phase and “Changer” otherwise. Patient characteristics of the Stable and Changer knees were compared to find contributing factors. The dHKA absolute variation during gait was 10.9±5.3° [2 .4° – 28.3°] for the whole cohort. The variation was greater for the varus knees (10.3±4.8° [2.4° – 26.3°]), than for the valgus knees (12.8±6.1° [2.9° – 28.3°], p=0.008). We found a low to moderate correlation (r = 0.266 to 0.553, p < 0 .001) between sHKA and the dHKA values for varus knees and no correlation valgus knees. Twenty two percent (36/165) of the knees demonstrated a switch in the dHKA (Changer). Proportion of Changer knees was 15% for varus sHKA versus 39% for valgus sHKA (p < 0.001). Lower limb radiographic measures of coronal alignment have limited value for predicting dynamic measures of alignment during gait.