The aims of this study were to assess the pre- and postoperative incidence of deep vein thrombosis (DVT) using routine duplex Doppler ultrasound (DUS), to assess the incidence of pulmonary embolism (PE) using CT angiography, and to identify the factors that predict postoperative DVT in patients with a pelvic and/or acetabular fracture. All patients treated surgically for a pelvic and/or acetabular fracture between October 2016 and January 2020 were enrolled into this prospective single-centre study. The demographic, medical, and surgical details of the patients were recorded. DVT screening of the lower limbs was routinely performed using DUS before and at six to ten days after surgery. CT angiography was used in patients who were suspected of having PE. Age-adjusted univariate and stepwise multiple logistic regression analysis were used to determine the association between explanatory variables and postoperative DVT.Aims
Methods
The use of antibiotic-loaded polymethylmethacrylate bone-cement spacers during two-stage exchange procedures is the standard in the treatment of patients with delayed prosthetic joint infection. The real antimicrobial activity of these spacers is unclear because the adherence of bacteria to cement might result in clinical recurrence of infection. The purpose of the study is to evaluate the in vitro formation of Cement disks (diameter = 6 mm) impregnated with gentamicin and colistin were submerged in bacterial suspensions of Methicillin-resistant Introduction
Materials and methods
Several studies have reported the rate of post-operative
mortality after the surgical treatment of a fracture of the hip,
but few data are available regarding the delayed morbidity. In this
prospective study, we identified 568 patients who underwent surgery
for a fracture of the hip and who were followed for one year. Multivariate
analysis was carried out to identify possible predictors of mortality
and morbidity. The 30-day, four-month and one-year rates of mortality
were 4.3%, 11.4%, and 18.8%, respectively. General complications
and pre-operative comorbidities represented the basic predictors
of mortality at any time interval (p <
0.01). In-hospital, four-month
and one-year general complications occurred in 29.4%, 18.6% and
6.7% of patients, respectively. After adjusting for confounding variables,
comorbidities and poor cognitive status determined the likelihood
of early and delayed general complications, respectively (p <
0.001). Operative delay was the main predictor of the length of
hospital stay (p <
0.001) and was directly related to in-hospital
(p = 0.017) and four-month complications (p = 0.008). Cite this article:
Modern total hip arthroplasty (THA) has shown a great improvement in pain, function and range of motion of patients but data on patients' quality of life after this surgery as assessed by validated tools are lacking. In this cohort study we evaluated the quality of life and functionality of 250 patients an average of 16 years (11–23) after THA using the SF-36 questionnaire, the Harris Hip Score, the WOMAC score, the Functional Comorbidity Index, and a study specific questionnaire. Models of multiple stepwise linear and logistic regression analysis were constructed to evaluate the relationships between the explanatory variables and the functional outcomes.BACKGROUND:
METHODS:
Coloured bone cements have been introduced to
make the removal of cement debris easier at the time of primary and
revision joint replacement. We evaluated the physical, mechanical
and pharmacological effects of adding methylene blue to bone cement
with or without antibiotics (gentamicin, vancomycin or both). The
addition of methylene blue to plain cement significantly decreased
its mean setting time (570 seconds (
The purposes of the present study were to assess the outcome of surgery for carpal tunnel syndrome (CTS), to evaluate histological findings of subsynovial connective tissue (SSCT) of patients with CTS in comparison with a control group, and to assess whether the histologic appearance of the flexor tenosynovium is correlated with clinical history, preoperative or postoperative physical examination, general health, symptoms and function as assessed by validated tools, or nerve conduction studies.
No studies have focused on the relationships between pathological changes in the subsynovial connective tissue and clinical or neurophysiological findings in patients suffering from carpal tunnel syndrome (CTS). Twenty-five consecutive patients (mean age 58.8±10 years; range 39–79) operated on for idiopathic CTS were evaluated before surgery and six month later. The indication for surgery was the presence of symptoms despite a three-month trial of conservative management. Mean duration of symptoms was 5.3±4.6 years (range 0.5–15). On admission, demographic and medical history data were recorded from all the patients. Subsequently, patients underwent preoperative physical examination and an outcome set including a mixed historic and objective scale (Hi-Ob), the Italian version of the Boston Carpal Tunnel Questionnaire (BCTQ) and the official Italian version of the SF-36 questionnaire was administered. The baseline diagnostic work-up included standard radiographs of the hand and wrist, blood examination and neurophysiological testing. Patients underwent open carpal tunnel release and thickened synovium from the flexor digitorum superficialis tendons was harvested. The number of cells, the number, diameter and density of the vessels, and the total surface of angiogenetic foci were measured. On the SF-36 questionnaire, the preoperative physical component summary (PCS) and mental component summary (MCS) scores averaged 36.5±4.2 and 40.8±5.7, respectively; at follow they averaged 47±10.2 and 46.8±7.3, respectively, with significant improvement for PCS. Preoperative and postoperative Hi-Ob scores measured 3.4±0.5 and 1.3±0.5, respectively. The BCTQ symptoms scale averaged 3.9±0.3 before surgery and 1.5±0.2 at follow up, whereas the BCQT functional status scale measured 3.4±0.5 at baseline and 1.4±0.3 six months after the operation. Univariate and multiple linear regression analysis were used to evaluate relationships between explanatory variables and outcomes. A high grade of preoperative neurophysiologic impairment was in direct relationship with the improvement in SF-36’s PCS score obtained with surgery (p=0.017). Conversely, no association was detected between neurophysiological grade and the postoperative improvement in Hi-Ob or BCQT scales. The univariate analysis showed a trend toward a direct association between number of vessels in the synovium and the improvement of BCTQ symptoms at follow-up (p=0.06). This trend was confirmed to a lesser extent at the multivariate analysis. With the numbers available, no other histological parameters were associated with the baseline neurophysiological findings or clinical outcomes. Although our results should be interpreted cautiously due to the small sample size, we conclude that the severity of pathological changes in the flexor synovium during CTS do not influence the baseline severity or outcome of this syndrome.
We have studied 180 patients (128 men and 52 women) who had undergone lumbar discectomy at a mean of 25.4 years (20 to 32) after operation. Pre-operatively, most patients (70 patients; 38.9%) had abnormal reflexes and/or muscle weakness in the leg (96 patients; 53.3%). At follow-up 42 patients (60%) with abnormal reflexes pre-operatively had fully recovered and 72 (75%) with pre-operative muscle impairment had normal muscle strength. When we looked at patient-reported outcomes, we found that the Short form-36 summary scores were similar to the aged-matched normative values. No disability or minimum disability on the Oswestry disability index was reported by 136 patients (75.6%), and 162 (90%) were satisfied with their operation. The most important predictors of patients’ self-reported positive outcome were male gender and higher educational level. No association was detected between muscle recovery and outcome. Most patients who had undergone lumbar discectomy had long-lasting neurological recovery. If the motor deficit persists after operation, patients can still expect a long-term satisfactory outcome, provided that they have relief from pain immediately after surgery.
Aim of the present study was to investigate clinical outcomes and quality of life after standard discectomy for lumbar disc herniation on a minimum 25-year follow-up throughout validated tools. Between 1973 and 1979, a total of 343 patients underwent single or double level standard lumbar discectomy at the Orthopaedic Department of Naples Federico II University Hospital, Italy. Fifty patients died from causes unrelated to disc surgery. Out of the remnants, one hundred fifty-eight patients could be traced and contacted by mail (46.1% survey rate). All of them (100% response rate) completed and sent back three questionnaires: the official Italian version of the Short Form-36 Health Survey (SF-36), the Oswestry Disability Questionnaire, and a questionnaire ideated by the authors to evaluate the degree of satisfaction with surgery. Forty-two patients even accepted to undergo clinic examination. The study population consisted of 97 males and 61 females. The mean age at the time of surgery was 37.8 +/− 8.7 years (18–62), whereas on follow up it was 65.8 +/− 8.9 (44–89). The average follow up in the study group was 27 years (25–31). The eight SF-36 scales averaged 72.53 +/− 31.3 for physical functioning, 63.1 +/− 30.1 for bodily pain, 61.30 +/− 44.4 for role-physical, 54.57 +/− 22.2 for general health, 56.62 +/− 19.2 for vitality, 72.08 +/− 30 for social functioning, 67.56 +/− 41.4 for role-emotional, and 62.28 +/− 19 for mental health. The mean SF-36 physical composite score (PCS) and mental composite score (MCS) were 44.2 +/− 11.6 (17.3–64.5) and 45.7 +/− 9,9 (13.2–62.4), respectively. The mean Oswestry Disability Score was 16.67 +/− 22.82 (0–96). One hundred forty-two patients (89.9%) were satisfied with the results of surgery, whereas sixteen (10.1%) were dissatisfied. One hundred and one (89.2%) would have had the same operation again. Nineteen patients underwent recurrent back surgery, giving a reoperation rate of 12%. As for the objective findings, we noted slight improvement of motor disturbances, hyporeflexia, and radicular tension signs with respect to preoperative period. Lumbar alignment abnormalities and trunk mobility did not show significant changes. On multivariate analysis worst SF-36 PCS scores were associated with increasing age (P = 0.039), low educational level (P = 0.002), and reoperation (P = 0.008). Similar correlations were appreciated for the Oswestry Disability Score. Negative role of female gender (P = 0.012) in determining the score of SF-36 MCS was also detected. To the best of our knowledge, no patient-oriented evaluation of lumbar discectomy outcomes has been reported with a similar ultra-long-term follow-up. The minimum 25-year results obtained in the present study were satisfying for both general health and disability indicators. The general health scores were similar to age-adjusted normative values.
