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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 45 - 45
1 Jul 2020
Mahmood F Burt J Bailey O Clarke J Baines J
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In the vast majority of patients, the anatomical and mechanical axes of the tibia in the coronal plane are widely accepted to be equivalent. This philosophy guides the design and placement of orthopaedic implants within the tibia and in both the knee and ankle joints. However, the presence of coronal tibial bowing may result in a difference between these two axes and hence cause suboptimal placement of implanted prostheses. Although the prevalence of tibial bowing in adults has been reported in Asian populations, to date no exploration of this phenomenon in a Western population has been conducted. The aim of this study was to quantify the prevalence of coronal tibial bowing in a Western population.

This was an observational retrospective cohort study using anteroposterior long leg radiographs collected prior to total knee arthroplasty in our high volume arthroplasty unit. Radiographs were reviewed using a Picture Archiving and Communication System. Using a technique previously described in the literature for assessment of tibial bowing, two lines were drawn, each one third of the length of the tibia. The first line was drawn between the tibial spines and the centre of the proximal third of the tibial medullary canal. The second was drawn from the midpoint of the talar dome to the centre of the distal third of the tibial medullary canal. The angle subtended by these two lines was used to determine the presence of bowing. Bowing was deemed significant if more than two degrees. The position of the apex of the bow determined whether it was medial or lateral. Measurements were conducted by a single observer and 10% of measurements were repeated by the same observer and also by two separate observers to allow calculation of intraclass correlation coefficients (ICCs).

A total of 975 radiographs consecutively performed in the calendar years 2015–16 were reviewed, 485 of the left leg and 490 of the right. In total 399 (40.9%) tibiae were deemed to have bowing more than two degrees. 232 (23.8%) tibiae were bowed medially and 167 (17.1%) were bowed laterally. The mean bowing angle was 3.51° (s.d. 1.24°) medially and 3.52° (s.d. 1.33°) laterally. Twenty-three patients in each group (9.9% medial/13.7% lateral) were bowed more than five degrees. The distribution of bowing angles followed a normal distribution, with the maximal angle observed 10.45° medially and 9.74° laterally. An intraobserver ICC of 0.97 and a mean interobserver ICC of 0.77 were calculated, indicating excellent reliability.

This is the first study reporting the prevalence of tibial bowing in a Western population. In a significant proportion of our sample, there was divergence between the anatomical and mechanical axes of the tibia. This finding has implications for both the design and implantation of orthopaedic prostheses, particularly in total knee arthroplasty. Further research is necessary to investigate whether prosthetic implantation based on the mechanical axis in bowed tibias results in suboptimal implant placement and adverse clinical outcomes.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_6 | Pages 36 - 36
1 Jul 2020
Mahmood F Clarke J Riches P
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The meniscus is comprised largely of type I collagen, as well as fibrochondrocytes and proteoglycans. In articular cartilage and intervertebral disc, proteoglycans make a significant contribution to mechanical stiffness of the tissue via negatively charged moieties which generate Donnan osmotic pressures. To date, such a role for proteoglycans in meniscal tissue has not been established. This study aimed to investigate whether meniscal proteoglycans contribute to mechanical stiffness of the tissue via electrostatic effects.

Following local University Ethics Committee approval, discs of meniscal tissue two millimetres thick and of five millimetres diameter were obtained from 12 paired fresh frozen human menisci, from donors < 6 5 years of age, with no history of osteoarthritis or meniscal injury. Samples were taken from anterior, middle and posterior meniscal regions. Each disc was placed within a custom confined compression chamber, permeable at the top and bottom only and then bathed in one of three solutions − 0.14M PBS (mimics cellular environment), deionised water (negates effect of mobile ions) or 3M PBS (negates all ionic effects). The apparatus was mounted within a Bose Electroforce 3100 materials testing machine and a 0.3N preload was applied. The sample was allowed to reach equilibrium, before being subjected to a 10% ramp compressive strain followed by a 7200 second hold phase. Equal numbers of samples from each meniscus and meniscal region were tested in each solution. Resultant stress relaxation curves were fitted to a nonlinear poroviscoelastic model with strain dependent permeability using FEBio finite element modelling software. Goodness of fit (R2) was assessed using a coefficient of determination. All samples were assayed for proteoglycan content. Comparison of resultant mechanical parameters was undertaken using multivariate ANOVA with Bonferroni adjustment for multiple comparisons.

36 samples were tested. A significant difference (p < 0 .05) was observed in the value of the Young's modulus (E) between samples tested in deionised water compared to 0.14M/3M PBS, with the meniscus found to be stiffest in deionised water (E = 1.15 MPa) and least stiff in 3M PBS (E = 0.43 MPa), with the value of E in 0.14M PBS falling in between (0.68 MPa). No differences were observed in the zero strain permeability or the exponential strain dependent/stiffening coefficients. The viscoelastic coefficient and relaxation time values were not found to improve model fit and were thus held at zero. The mean R2 value was 0.78, indicating a good fit and did not differ significantly between solutions. Proteoglycan content was not found to differ with solution, but was found to be significantly increased in the middle region of both menisci.

Proteoglycans make a significant electrostatic contribution to mechanical stiffness of the meniscus, increasing it by 58% in the physiological condition, and are hence integral to its function. It is important to include the influence of ionic effects when modelling meniscus, particularly where fluid flow or localised strain is modelled. From a clinical perspective, it is critical that meniscal regeneration strategies such as scaffolds or allografts attempt to preserve, or compensate for, the function of proteoglycans to ensure normal meniscal function.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_3 | Pages 10 - 10
1 Apr 2015
Mackay N Mahmood F Chan K Baird K McMillan S Logan J Dowell C Miller R
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Ankle lateral ligament complex injury is common. Traditional ‘Brostrum’ repair, performed either open or arthroscopically, still has a protracted post-operative period. The ‘Internal Brace’ provides a scaffold for the ligament repair and acts as a ‘check-rein’ preventing further injury.

16 patients with ankle instability and injury to the Anterior-Talo-Fibular-Ligament (ATFL) confirmed on MRI were identified. All had completed a period of conservative treatment. All had symptoms of pain in the region of the ATFL and described a feeling of instability. Surgery was performed under general anaesthetic and regional popliteal block. Anterior ankle arthroscopy demonstrated a positive ‘drive through’ in all cases. The ATFL was absent and in the majority replaced by incompetent scar. Scar tissue was removed from the anterior aspect of the ankle allowing visualisation of the fibula and lateral talar neck. Using the Internal Brace system (Arthrex), a 3.5mm swivel-lock with fibre-tape was placed into the fibula. With the ankle in plantar flexion, to allow appropriate tensioning, the distal end of the fibre-tape was secured to the talar neck, at a 45 degree angle, with a 4.75mm biotenodesis screw. The patient was placed into a moon-boot for 7–10 days and mobilised fully weight-bearing. Pre-op score, using EDQ-5, MOXFQ, AOFAS and visual analogue scores, with post-op PROMS were performed.

All patients reported improvement in their symptoms at 6 week visit. The majority were back to normal activities at 12 weeks. The few that were not, had missed physiotherapy appointments for various reasons. There were no infections and no implant failures.

Arthroscopy allows direct visualisation for accurate placement of the Internal Brace. Post-operatively recovery is expedited due to the stability provided by the ‘Brace’, permitting a more aggressive rehabilitation programme. The greatest potential is arguably for the elite athlete, where an accelerated return to full activity has significant occupational implications.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_31 | Pages 23 - 23
1 Aug 2013
Mahmood F Davison M
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Digital radiographs are routinely used for preoperative planning, both in trauma and elective patients; particularly in preoperative templating for total hip replacement. Traditional wisdom holds that radiographs are oversized, though the degree to which this occurs is unclear. Although digital templating systems offer the use of calibration markers, this option is not always availed. We aimed to ascertain the typical magnification in departmental xrays of the hip, both to determine the typical degree of magnification as well as ascertain its consistency.

All patients undergoing dynamic hip screw fixation (DHS) in our unit over the past 12 months were identified. Using the PACS system, subsequent xrays of the patient with the implant in situ were identified; both anteroposterior abdominal and pelvic films were used. The width of a standard DHS screw (12.5 mm) was compared with the width measured on the xrays to determine a magnification factor. 164 patients were identified, of these 39 had undergone DHS fixation with subsequent xrays. 3 films were focused on the abdomen but provided good coverage of the hip also. 2 xrays were excluded – both due to limited quality. The average magnification was 26.4% (range 15.5%–42%). There was limited consistency between images.

Radiographs are a core investigation in the assessment of the orthopaedic patient. The advent of picture archiving and communications systems (PACS) has allowed the enterprising surgeon to pre-emptively plan their surgical technique and implant use. However, the utility of non-calibrated images in planning implant size is limited by variation in magnification. Surgeons should be cautious in using such images to guide their implant usage.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_31 | Pages 24 - 24
1 Aug 2013
Mahmood F Beattie N Hendrix M
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Soft tissue balancing is critical to successful knee arthroplasty. Pre-operative planning ensures that the surgeon is prepared for any eventuality. We report a large femoral exostosis resulting in gross instability, requiring revision to a constrained implant.

An 81 year old female presented with osteoarthritis of the left knee. Xray showed a medial bony mass. CT noted a large bony exostosis arising from the posteromedial femoral condyle. Review showed the exostosis was not related to the medial collateral ligament (MCL). At surgery, the exostosis was noted to be tenting the MCL – excision resulted in complete flaccidity. A trial of the Biomet AGC prosthesis revealed gross medial instability. The decision was taken to convert to a DePuy Sigma TC3 system. Whilst removing TC3 trial components, a lateral condyle fracture occurred. This was fixed with a 1/3 tubular plate and interfragmentary screw. The TC3 system and an AGC patellar button were found to be congruent. A small lateral release was performed, the deep MCL was replaced with tagging sutures through the MCL and the pes anserinus. At 9 weeks post operatively, the patient was pain free and mobilising independently. The knee was stable, with range of movement from 0 to 110 degrees.

To our knowledge, this is the first report of such a complication in the literature. It highlights that despite optimal preoperative planning, the surgeon must be prepared to adapt to the situation at hand. It also highlights the importance of having ‘bail out’ options available on shelf when performing routine surgery.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 6 | Pages 799 - 804
1 Jun 2012
Hems TEJ Mahmood F

We reviewed 101 patients with injuries of the terminal branches of the infraclavicular brachial plexus sustained between 1997 and 2009. Four patterns of injury were identified: 1) anterior glenohumeral dislocation (n = 55), in which the axillary and ulnar nerves were most commonly injured, but the axillary nerve was ruptured in only two patients (3.6%); 2) axillary nerve injury, with or without injury to other nerves, in the absence of dislocation of the shoulder (n = 20): these had a similar pattern of nerve involvement to those with a known dislocation, but the axillary nerve was ruptured in 14 patients (70%); 3) displaced proximal humeral fracture (n = 15), in which nerve injury resulted from medial displacement of the humeral shaft: the fracture was surgically reduced in 13 patients; and 4) hyperextension of the arm (n = 11): these were characterised by disruption of the musculocutaneous nerve. There was variable involvement of the median and radial nerves with the ulnar nerve being least affected.

Surgical intervention is not needed in most cases of infraclavicular injury associated with dislocation of the shoulder. Early exploration of the nerves should be considered in patients with an axillary nerve palsy without dislocation of the shoulder and for musculocutaneous nerve palsy with median and/or radial nerve palsy. Urgent operation is needed in cases of nerve injury resulting from fracture of the humeral neck to relieve pressure on nerves.