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Bone & Joint Research
Vol. 11, Issue 12 | Pages 854 - 861
1 Dec 2022
Park TJ Park SY Cho W Oh H Lee HJ Abd El-Aty AM Bayram C Jeong JH Jung TW

Aims

Myokine developmental endothelial locus-1 (DEL-1) has been documented to alleviate inflammation and endoplasmic reticulum (ER) stress in various cell types. However, the effects of DEL-1 on inflammation, ER stress, and apoptosis in tenocytes remain unclear.

Methods

Human primary tenocytes were cultured in palmitate (400 μM) and palmitate plus DEL-1 (0 to 2 μg/ml) conditions for 24 hours. The expression levels of ER stress markers and cleaved caspase 3, as well as phosphorylated 5' adenosine monophosphate-activated protein kinase (AMPK) and autophagy markers, were assessed by Western blotting. Autophagosome formation was measured by staining with monodansylcadaverine, and apoptosis was determined by cell viability assay and caspase 3 activity assay.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 81 - 81
1 Jan 2016
Choi CH Chung KS Lee JK Lee HJ
Full Access

Introduction

The purpose of this study was to evaluate the mid-term clinical and radiological results in patients who were managed by double metal augmentations in proximal tibial uncontained bony defects undergoing primary or revision total knee arthroplasty

Materials and Methods

We performed double metal augmentations in proximal tibial uncontained bony defects undergoing total knee arthroplasty. Out of total 14 patients, 8 patients (4 priamry arthroplasty, 4 revision arthroplasty), mean 61.3 (50–80) years, were available for review at least 5 years follow up. The average follow up period was 86.3(60–99) months. Range of motion, American Knee Society Score were evaluated pre- and postoperatively as a clinical values. Another clinical assessments undertaken at the final reviews, Western Ontario and McMaster Universities osteoarthritis index (WOMAC), Oxford knee score (OKS), Short Form-36 (SF-36), Lower extremity functional scale (LEFS), and Lower extremity activity scale (LEAS) were checked. Radiological results, involving presence of radiolucent lines (RLLs) > 1mm in width, and osteolysis at the block-cement-bone interface were taken under fluoroscopic images at postoperatively and annually thereafter.


The Bone & Joint Journal
Vol. 97-B, Issue 2 | Pages 229 - 234
1 Feb 2015
Choi W Lee HJ Kim D Lee C Lee BG Kim J Lee K

We performed a retrospective study to determine the effect of osteoporosis on the functional outcome of osteoporotic distal radial fractures treated with a volar locking plate. Between 2009 and 2012 a total of 90 postmenopausal women with an unstable fracture of the distal radius treated with a volar locking plate were studied. Changes in the radiological parameters of 51 patients with osteoporosis (group 1, mean age 66.9, mean T-score –3.16 (sd 0.56)) were not significantly different from those in 39 patients without osteoporosis (group 2, mean age 61.1, mean T-score –1.72 (sd 0.57)). The mean Disabilities of the Arm, Shoulder and Hand (DASH) score at final follow-up was 11.5 (sd 12.2) in group 1 and 10.5 (sd 13.25) in group 2. The mean modified Mayo wrist score at final follow-up was 79.0 (sd 14.04) in group 1 and 82.6 (sd 13.1) in group 2. However, this difference was not statistically significant (p = 0.35 for DASH score, p = 0.2 for modified Mayo wrist score). Univariable and multivariable logistic regression analysis showed that only the step-off of the radiocarpal joint was related to both a poor DASH and modified Mayo wrist score. Pearson’s correlation coefficient showed a weak negative relationship only between the T-score and the change in volar tilt (intraclass coefficient –0.26, p = 0.02).

We found that osteoporosis does not have a negative effect on the functional outcome and additional analysis did not show a correlation between T-score and outcome.

Cite this article: Bone Joint J 2015;97-B:229–34.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 66 - 66
1 Apr 2013
Kim JW Oh CW Lee HJ Yoon JP Oh JK Kyung HS
Full Access

Background

Although minimally invasive plate osteosynthesis (MIPO) has become popular option for humeral shaft fractures, indirect reduction and its maintenance are technically challenging. The purpose of this study is to describe a reproducible technique utilizing an external fixator during MIPO and to assess its outcomes.

Methods

Twenty-nine cases with a mean age of 37.1 years were included. There were 7 simple (type A) and 22 comminuted (type B or C) fractures. Indirect reduction was achieved and maintained by a monolateral external fixator on the lateral aspect of humeral shaft, and MIPO was performed on the anterior surface. Union, alignment, complications, and functional results of the shoulder and elbow were assessed.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 15 - 15
1 Apr 2013
Kim J Oh CW Oh JK Lee HJ Kyung HS
Full Access

Background

To establish relative fixation strengths of a single lateral locking plate, a double locking plate, and a tibial nail in treatment of proximal tibial extra-articular fractures.

Methods

Three groups of composite tibial synthetic bones consisting of 5 specimens per group were included; lateral plating (LP) using a LCP-PLT (locking compression plate-proximal lateral tibia), double plating (DP) using a LCP-PLT and a LCP-MPT (locking compression plate-medial proximal tibia), and intramedullary nailing (IN) using an ETN (expert tibial nail). To simulate a comminuted fracture model, a gap osteotomy measuring 1 cm was cut 8 cm below the joint. For each tibia, a minimal preload of 100N was applied before loading to failure. A vertical load was applied at 25mm/min until tibia failure.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 63 - 63
1 Apr 2013
Kim J Oh C Oh JK Lee HJ
Full Access

Background

Although gradual bone transport may provide a large-diameter bone, complications are common with the long duration of external fixation. To reduce such complications, a new technique of bone transport with a locking plate has been done for tibial bone defect.

Methods

In 13 patients (mean age, 38.9 years) of chronic osteomyelitis or traumatic bone defect, segmental transport was done using external fixator with a locking plate. In surgical technique, a locking plate was fixed submuscularly, holding the proximal and distal segments. Then, the external fixator for transport was fixed without contact of the locking plate. After docking, 2 or 3 screws were fixed at the transported segment through the plate holes. At the same time, the external fixator was removed.


The Bone & Joint Journal
Vol. 95-B, Issue 3 | Pages 396 - 400
1 Mar 2013
Rhee SH Kim J Lee YH Gong HS Lee HJ Baek GH

The purpose of this study was to evaluate the risk of late displacement after the treatment of distal radial fractures with a locking volar plate, and to investigate the clinical and radiological factors that might correlate with re-displacement. From March 2007 to October 2009, 120 of an original cohort of 132 female patients with unstable fractures of the distal radius were treated with a volar locking plate, and were studied over a follow-up period of six months. In the immediate post-operative and final follow-up radiographs, late displacement was evaluated as judged by ulnar variance, radial inclination, and dorsal angulation. We also analysed the correlation of a variety of clinical and radiological factors with re-displacement. Ulnar variance was significantly overcorrected (p < 0.001) while radial inclination and dorsal angulation were undercorrected when compared statistically (p <  0.001) with the unaffected side in the immediate post-operative stage. During follow-up, radial shortening and dorsal angulation progressed statistically, but none had a value beyond the acceptable range. Bone mineral density measured at the proximal femur and the position of the screws in the subchondral region, correlated with slight progressive radial shortening, which was not clinically relevant.

Volar locking plating of distal radial fractures is a reliable form of treatment without substantial late displacement.

Cite this article: Bone Joint J 2013;95-B:396–400.