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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVIII | Pages 27 - 27
1 Jun 2012
Young PS Middleton RG Learmonth ID Minhas THA
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Total hip arthroplasty is well established as a successful treatment modality for end stage arthritis, with a variety of components currently available. However, utilising traditional stemmed implants in patients with distorted proximal femoral geometry can be technically challenging with increased risk of complications.

We present seven patients with distorted proximal femoral anatomy or failed hip arthroplasty in whom a technically challenging primary or revision operation was simplified by use of a Proxima stem. This is a short, stemless, metaphyseal loading implant with a pronounced lateral flare.

At twelve months follow up there have been no complications with average improvement in Oxford and Harris scores of forty and forty-nine respectively. Radiological analysis shows all stems to be stable and well fixed.

Designed primarily as a bone conserving implant for primary hip arthroplasty we propose that the Proxima prosthesis also be considered in cases where a conventional stemmed implant may not be suitable due to challenging proximal femoral anatomy. The use of the stemless Proxima implant provided a simple solution in seven difficult and potentially lengthy complex primary and revision hip arthroplasties with gratifying clinical and radiological outcomes.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 6 | Pages 725 - 729
1 Jun 2009
Livesey C Wylde V Descamps S Estela CM Bannister GC Learmonth ID Blom AW

We undertook a randomised controlled trial to compare the outcomes of skin adhesive and staples for skin closure in total hip replacement. The primary outcome was the cosmetic appearance of the scar at three months using a surgeon-rated visual analogue scale. In all, 90 patients were randomised to skin closure using either skin adhesive (n = 45) or staples (n = 45). Data on demographics, surgical details, infection and oozing were collected during the in-patient stay. Further data on complications, patient satisfaction and evaluation of cosmesis were collected at three-month follow-up, and a photograph of the scar was taken. An orthopaedic and a plastic surgeon independently evaluated the cosmetic appearance of the scars from the photographs. No significant difference was found between groups in the cosmetic appearance of scars at three months (p = 0.172), the occurrence of complications (p = 0.3), or patient satisfaction (p = 0.42). Staples were quicker and easier to use than skin adhesive and also less expensive. Skin adhesive and surgical staples are both effective skin closure methods in total hip replacement.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 1 | Pages 37 - 43
1 Jan 2009
Hassaballa M Mehendale S Poniatowski S Kalantzis G Smith E Learmonth ID

Loss of bone stock is a major problem in revision surgery of the hip. Impaction bone grafting of the femur is frequently used when dealing with deficient bone stock. In this retrospective study a consecutive series of 68 patients (69 hips) who had revision of a hip replacement with femoral impaction grafting were reviewed. Irradiated bone allograft was used in all hips. Radiological measurement of subsidence of the stem, incorporation of the graft and remodelling was carried out and showed incorporation of the graft in 26 of 69 hips (38%). However, there was no evidence of trabecular remodelling. Moderate subsidence of 5 mm to 10 mm occurred in ten hips (14.5%), and massive subsidence of > 10 mm in five (7.2%).

The results of this study are less favourable than those of others describing studies of revision of the femoral stem using impaction bone grafting. The absence of the characteristic changes of graft remodelling noted in other series raises the question as to whether irradiated bone graft may be a significant factor influencing the post-operative outcome.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 11 | Pages 1422 - 1427
1 Nov 2008
Utting MR Raghuvanshi M Amirfeyz R Blom AW Learmonth ID Bannister GC

We have reviewed 70 Harris-Galante uncemented acetabular components implanted as hybrid hip replacements with cemented stems between 1991 and 1995 in 53 patients whose mean age was 40 years (19 to 49). The mean follow-up was for 13.6 years (12 to 16) with no loss to follow-up. We assessed the patients both clinically and radiologically.

The mean Oxford hip score was 20 (12 to 46) and the mean Harris hip score 81 (37 to 100) at the final review. Radiologically, 27 hips (39%) had femoral osteolysis, 13 (19%) acetabular osteolysis, and 31 (44%) radiolucent lines around the acetabular component. Kaplan-Meier survival curves were constructed for the outcomes of revision of the acetabular component, revision of the component and polyethylene liner, and impending revision for progressive osteolysis.

The cumulative survival for revision of the acetabular component was 94% (95% confidence interval 88.4 to 99.7), for the component and liner 84% (95% confidence interval 74.5 to 93.5) and for impending revision 55.3% (95% confidence interval 40.6 to 70) at 16 years.

Uncemented acetabular components with polyethylene liners undergo silent lysis and merit regular long-term radiological review.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 537 - 537
1 Aug 2008
White SP Lee M Learmonth ID
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Introduction: A composite femoral stem was introduced with a structural stiffness similar to that of the native femur to promote proximal load transfer. This consisted of a cobalt-chromium alloy core surrounded by an injection-moulded layer of polyaryletherketone covered with a porous titanium mesh.

Materials and Method : 31 primary total hip replacement stems were implanted in 26 patients with an average age of 37 years (range 17–57) using the Epoch Stem (Zimmer, Warsaw, IN) as part of a prospective multicentre trial. A cementless Harris-Galante I acetabular component with a 28mm polyethylene insert was used in 28 cases, a Plasma cup (Aesculap) in 1 case and a bipolar head in 2 cases. Annual follow-up using Harris Hip Scores and radiographic evaluation was performed for a mean of 10.1 years.

Results: Harris Hip Scores improved from a mean of 56 points preoperatively to 90 at the time of last follow-up. Radiographs showed no stem migration or loosening. 4 cases with polyethylene wear showed trochanteric osteolysis. Specific radiographic features noted were calcar rounding in 10 cases and improvement in calcar appearance with squaring in 4 cases. Calcar resorption was seen in 1 case associated with polyethylene wear. There have been 9 instances of revision of the head or acetabular component – 3 liner exchanges for polyethylene wear, 3 liner exchanges for dissociation, 1 acetabular component revision for infection and 2 bipolar heads revised to unipolar heads with cementless acetabular component for pain. No stem has required or requires revision.

Discussion: The Epoch stem resulted in an excellent clinical outcome, with evidence of radiographic stability and proximal bone preservation, and no cases of stem revision in a small cohort of young patients at 10-year follow-up. The limitation of reconstruction in this cohort of young patients has been the acetabular component.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 5 | Pages 567 - 573
1 May 2007
Keegan GM Learmonth ID Case CP

The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 257 - 257
1 May 2006
Hassaballa MA Revill A Penny B Newman JH Learmonth ID
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Introduction: Correct prosthesis alignment and joint line reproduction in total knee replacement (TKR) is vital for a successful clinical outcome. It is acknowledged that the ideal coronal alignment of the knee following TKR should be between 4–10 degrees of valgus. A neutral or varus knee is associated with a higher failure rate. Previous studies have shown that ideal alignment is achieved in only around two-thirds of cases.

Joint line elevation > 8mm has been associated with inferior clinical outcome, and depression associated with retropatellar pain and increased risk of patella subluxation.

Recently, modifications have been made to the Kine-max-Plus Total Knee System instrumentation, theoretically providing better internal fixation to prevent a varus cut and a 12 mm measured resection from the “normal” tibial plateau. This study aims to examine whether these changes result in an improvement in alignment, and a more reliable restoration of joint line.

Materials and Methods: Two consecutive series, each of 75 patients who had undergone TKR using either the old (Group A) or the new (Group B) instrumentation were included in the study. Antero-posterior and lateral preoperative and postoperative knee radiographs were assessed using the American knee society radiographic analysis for prosthesis postionoing by 2 independent observers. The Tibial and Femoral Component Angles in the coronal plane (cTCA and cFCA) and in the sagittal plane (sTCA and sFCA) were measured, as was the change in joint line height.

Conclusion: Our results suggest that use of the new instrumentation is associated with better restoration of joint line, and is more effective in preventing implantation of the tibial component in varus. These figures relating to a modern instrumentation system provide a yardstick against which computer assisted and robotic surgery can be judged. Long-term follow-up will be required to assess the clinical significance of these results.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 12 | Pages 1636 - 1638
1 Dec 2005
Blom AW Astle L Loveridge J Learmonth ID

Polyethylene liners of modular acetabular components wear sometimes need to be replaced, despite the metal shell being well fixed. Replacing the liner is a relatively simple procedure, but very little is known of the outcome of revision. We prospectively followed up 1126 Harris-Galante I metal-backed, uncemented components for between nine and 19 years. We found 38 (3.4%) liners of 1126 acetabular components wore and required revision. These revisions were then followed up for a mean of 4.8 years. The rate of dislocation was 28.9%. Nine of the dislocations occurred once and two were recurrent.

The overall secondary revision rate was three of 38 total hip replacements (7.9%) at a mean follow-up of 4.8 years. This gives a 92.1% survivorship (35 of 38) at under five years. In isolated revision of a liner, we had a complication rate of 23% (three of 13). In revision of a liner combined with revision of the femoral stem, there was a complication rate of 48% (12 of 25). We discuss possible reasons for the high dislocation rates.

Leaving the well-fixed acetabular shell in situ leads to an increased risk of instability. However, this needs to be balanced against the otherwise low complication rate for revision of the liner. Patients should be consented accordingly.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 10 | Pages 1439 - 1444
1 Oct 2005
Davies AP Sood A Lewis AC Newson R Learmonth ID Case CP

Previous research has shown an increase in chromosomal aberrations in patients with worn implants. The type of aberration depended on the type of metal alloy in the prosthesis. We have investigated the metal-specific difference in the level of DNA damage (DNA stand breaks and alkali labile sites) induced by culturing human fibroblasts in synovial fluid retrieved at revision arthroplasty.

All six samples from revision cobalt-chromium metal-on-metal and four of six samples from cobalt-chromium metal-on-polyethylene prostheses caused DNA damage. By contrast, none of six samples from revision stainless-steel metal-on-polyethylene prostheses caused significant damage. Samples of cobalt-chromium alloy left to corrode in phosphate-buffered saline also caused DNA damage and this depended on a synergistic effect between the cobalt and chromium ions.

Our results further emphasise that epidemiological studies of orthopaedic implants should take account of the type of metal alloy used.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 6 | Pages 786 - 789
1 Jun 2005
Grobler GP Learmonth ID Bernstein BP Dower BJ

We retrospectively reviewed, ten years after surgery, 100 consecutive total hip replacements in which the Duraloc 300 cup had been used. Post-operative radiographs were analysed for placement of the cup and interface gaps and follow-up radiographs for lucent lines, osteolysis, wear and migration.

All the components were found to be stable with no evidence of loosening. The mean rate of wear was 0.12 mm/year. Three hips developed acetabular osteolysis at the level of the apex hole. Two have successfully undergone bone grafting without removal of the implants and one patient is awaiting surgery. The Duraloc 300 cup has a survival of 100% at ten years with no aseptic loosening and a low incidence of pelvic osteolysis.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 3 | Pages 421 - 425
1 Mar 2005
Blom AW Cunningham JL Hughes G Lawes TJ Smith N Blunn G Learmonth ID Goodship AE

This study investigates the use of porous biphasic ceramics as graft extenders in impaction grafting of the femur during revision hip surgery.

Impaction grafting of the femur was performed in four groups of sheep. Group one received pure allograft, group two 50% allograft and 50% BoneSave, group three 50% allograft and 50% BoneSave type 2 and group four 10% allograft and 90% BoneSave as the graft material. Function was assessed using an index of pre- and post-operative peak vertical ground reaction force ratios. Changes in bone mineral density were measured by dual energy X ray absorptiometry (DEXA) scanning. Loosening and subsidence were assessed radiographically and by histological examination of the explanted specimens.

There was no statistically significant difference between the four groups after 18 months of unrestricted functional loading for all outcome measures.


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 8 | Pages 1192 - 1196
1 Nov 2004
Maccauro G Piconi C Burger W Pilloni L De Santis E Muratori F Learmonth ID

We studied factors contributing to the initiation of fracture and failure of a zirconia ceramic femoral head. The materials retrieved during a revision total hip replacement were submitted to either visual, stereomicroscopic and scanning electron microscopy (SEM) or SEM and energy-dispersive x-ray analysis. X-ray diffraction was performed in order to investigate the extent of tetragonal to monoclinic phase transition. Histological examination was performed on the periprosthetic tissues.

The results showed that failure was due to the propagation during clinical use of defects which may have been introduced into the material during the processing of the ceramic, rather than those intrinsic to zirconia. The literature relating to previous failures of zirconia components is reviewed.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 75 - 75
1 Jan 2004
Hancock NJ Smith EJ Learmonth ID Coates D
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In the future, registration with a surgical speciality may require no more than the demonstration of core knowledge in the generality of that speciality and in the diagnosis and management of the related acute conditions. Sub-speciality training will be recognised separately. Rationalisation of referral patterns would then require that primary care practitioners are aware of these special abilities.

A questionnaire was sent to 1207 General Practitioners in the Avon, Leicestershire and Central London regions. The response rate was 86.2% (n = 1040). Views were sought on the management and referral of patients experiencing problems with existing hip replacements. These included the use of pre referral radiographs, whether practitioners would preferentially refer to a specialist hip surgeon and whether they believed that referral to a generalist could compromise patient care.

The majority GP’s arranged pre referral radiographs (84.2%). A third (34.2%) indicated that they would refer to any orthopaedic surgeon. 50.0% felt that outcome could be compromised if the patient was seen by an orthopaedic surgeon without a special interest in hip surgery.

There appears to be a need for more scientific information for GP’s and an agreed referral protocol. It is expected that rationalisation the referral system would lead to closer matching of patients needs with specialists’ abilities.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 76 - 76
1 Jan 2004
Lankester BJA Spencer RF Learmonth ID
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Introduction: The CPS-Plus cemented, collarless, polished stem, is a double-taper design with rectangular cross section. An additional proximal stem centraliser ensures optimal alignment of the stem and an even cement mantle and has been shown to increase cement pressurisation during insertion.

Guidelines from the National Institute of Clinical Excellence (NICE) recommend comparative clinical evaluation for prostheses without long-term follow-up data and set an initial ‘benchmark’ for performance at 3 years.

Data collection for the CPS-Plus stem is on-going as part of a multi-centre prospective clinical trial. 227 patients have been recruited to the trial and 70 of these have reached 3 years follow-up.

Method: Patients were recruited to the study by surgeons working at three centres in the UK and two in Norway. Patients were fully evaluated pre-operatively. Operative details, post-operative course and follow-up visits at 3, 6, 12, 24, and 36 months were recorded. Postoperative clinical progress was monitored using recognised scoring systems and radiographic assessment.

Results: The mean Harris hip score (0 – 100) improved from 42.7 pre-op to 91.6 at 6 months and 95.8 at 3 years. The mean Merle d’Aubigne and Postel score (0 – 18) improved from 8.55 pre-op to 16.09 at 6 months and 17.08 at 3 years. The mean Oxford hip score (60 – 12) improved from 41.6 pre-op to 14.1 at 3 years. Radiological subsidence at 3 years is less that 1.5mm in 97% of patients and less than 3mm in the remainder. From all 227 implants, there has been one revision for deep infection. There have been no cases of aseptic loosening. Other significant complications include one peri-prosthetic fracture and 4 dislocations, but these were not thought to be related to the design of the implant.

Discussion: The early results of the CPS-Plus femoral stem are encouraging and the prosthesis achieves the 3-year benchmark set out in the NICE guidelines, with a zero revision rate in the first 70 patients recruited to the trial. The prosthesis shares many design features with other well-established collarless, polished, tapered stems. The ease of accurate insertion and improved cement pressurisation resulting from its unique design features should ensure excellent medium to long-term outcome. The multi-centre clinical trial will continue to monitor progress.


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 1 | Pages 13 - 19
1 Jan 2004
Learmonth ID


The Journal of Bone & Joint Surgery British Volume
Vol. 85-B, Issue 5 | Pages 706 - 711
1 Jul 2003
Whitehouse SL Lingard EA Katz JN Learmonth ID

We used prospective data from 862 total knee and 716 total hip replacements three years after surgery in order to derive and validate a reduced Western Ontario and McMasters University Osteoarthritis Index (WOMAC) function scale. The reduced scale was derived using the advice of clinical experts as well as analysis of data. The scale was tested for validity, reliability and responsiveness.

Items which were retained included: ascending stairs, rising from sitting, walking on the flat, getting in or out of a car, putting on socks, rising from bed, and sitting.

The reduced and full scales had comparable, moderate correlations with other measures of function, confirming convergent validity. Cronbach’s alpha was high (α > 0.85) with the reduced scale confirming reliability. Responsiveness was greater for the reduced scale (full = 1.4, reduced = 1.6).

This reduced version of the WOMAC function scale provides a practical, valid, reliable and responsive alternative to the full function scale for use after total joint replacement. Further work is needed to demonstrate its wider applicability.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 36 - 36
1 Jan 2003
Langdon IJ Hardin R Learmonth ID
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We hypothesise that patients are unable to recall much of the information imparted during the informed consent procedure. This may have important medico-legal consequences and increase patient anxiety. Receiving the information in a written format may improve patient recall. There have been no previous studies testing recall or information sheets for British orthopaedic patients.

We performed a randomised controlled trial of consent for total hip arthroplasty, with one group of patients receiving a written information sheet with explanation as necessary, and the control group receiving the same information verbally. The consent was obtained at a pre-operative assessment clinic approximately three weeks before admission. On admission, a questionnaire was filled in both groups of patients to assess recall.

There were no significant differences between the two groups with regard to type of arthroplasty (revision or primary), age, or days from consent to admission.

The group receiving written information performed better in the recall questionnaire. This group were pleased to have received the information sheet, there were no negative comments about the sheet. In the group who received verbal information, most expressed a desire to receive a written information sheet. One patient stated that she would rather know nothing about the operation and would have refused a sheet. We conclude that patient information sheets are an acceptable and appropriate method of imparting the necessary information for informed consent for total hip arthroplasty, and are more effective than standard verbal informed consent.

Medico-legally, the sheet could be a permanent record of what was discussed. This should prevent disputes and claims due to poor recall of the consent procedure.


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 7 | Pages 1075 - 1081
1 Sep 2001
Doherty AT Howell RT Ellis LA Bisbinas I Learmonth ID Newson R Case CP

The long-term biological effects of wear debris are unknown. We have investigated whether there is any evidence of cumulative mutagenic damage in peripheral blood lymphocytes of patients undergoing revision arthroplasty of predominantly metal-on-plastic total hip replacements compared with those at primary arthroplasty.

There was a threefold increase in aneuploidy and a twofold increase in chromosomal translocations which could not be explained by the confounding variables of smoking, gender, age and diagnostic radiographs. In the patients with TiVaAl prostheses there was a fivefold increase in aneuploidy but no increase in chromosomal translocations. By contrast, in patients with cobalt-chrome prostheses there was a 2.5-fold increase in aneuploidy and a 3.5-fold increase in chromosomal translocations. In six patients with stainless-steel prostheses there was no increase in either aneuploidy or chromosomal translocations.

Our results suggest that future epidemiological studies of the putative long-term risks of joint replacement should take into account the type of alloy used in the prosthesis.


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 2 | Pages 177 - 182
1 Mar 2001
Taylor AH Shannon M Whitehouse SL Lee MB Learmonth ID

We describe the results of 76 total arthroplasties of the hip for stage-III or stage-IV avascular necrosis of the femoral head. Harris Galante Porous cups were used in 63 patients between 1986 and 1994 and followed prospectively. We reviewed 70 hips with a follow-up of more than five years (mean 7.6).

At the latest review the mean Harris Hip Score had improved from a preoperative value of 29 ± 14.7 to 94 ± 6.8. Radiologically, there was no evidence of acetabular migration. The rate of revision for the femoral component was 8.6%, three being undertaken for loosening and three to allow downsizing of the femoral head. The rate of revision for the acetabular component was 7.1% (five cups). At the time of revision none of the cups was clinically loose, and only required the liner to be changed.

The rate of complications was low with no case of deep infection or dislocation, but nine of the 76 hips (11.8%) showed grade-III heterotopic ossification. Previous studies of patients undergoing cemented total hip arthroplasty for the treatment of advanced avascular necrosis have indicated a high incidence of loosening of the acetabular component. Our findings show good medium-term results using the Harris Galante Porous cup for acetabular reconstruction, together with a variety of cemented femoral components, for the treatment of this difficult problem.


The Journal of Bone & Joint Surgery British Volume
Vol. 80-B, Issue 3 | Pages 414 - 416
1 May 1998
Eldridge JDJ Avramidis K Lee M Learmonth ID

There are several techniques for the accurate measurement of the migration of components after arthroplasty some of which require the operative placement of tantalum balls. We have reviewed the position and migration of these markers in 64 patients after total hip arthroplasty.

In 40% of cases, one or more balls was seen to be outside the proximal femur on the postoperative radiograph, although all were considered to be within the bone at operation. In two hips, one ball appeared to have migrated towards the joint, although none was seen within the joint. Misplacement was not related to the experience of the surgeon or the operative approach.

Migration analysis which necessitates the insertion of tantalum balls requires careful technique to avoid a potential source of third-body wear. It should probably be used only for research in small series of patients.