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Total knee arthroplasty is associated with early postoperative pain. Appropriate pain management is important to facilitate postoperative rehabilitation and positive functional outcomes. This study compares outcomes in TKA with three techniques; local infiltration analgesia, single shot femoral nerve block and intrathecal morphine.

Methods

Forty-five patients undergoing elective primary Total Knee Arthroplasty (TKA) with were randomized into one of three groups in a double blind proof of concept study.

Study arm 1 received local infiltration analgesia ropivacaine intra-operatively, an elastomeric device of ropivacaine for 24 hours post-op.

Study arm 2 received a femoral nerve block of ropivacaine with placebo local infiltration analgesia and placebo intrathecal morphine.

Study arm 3 received intrathecal morphine, placebo femoral nerve block and placebo local infiltration analgesia. All patients received standardized pre-operative, intraoperative and Post-operative analgesic medication.

Participants were mobilized at 4 hrs, 24hrs and 48 hrs post operation. Range of Motion, Visual Analogue Scale (VAS) pain intensity scores and two minute walk test and Timed Up and Go test were performed. Postoperative use of analgesic drugs was recorded. Knee Society Score (KSS), Oxford Knee Score and Knee Injury and Osteoarthritis Outcome Score (KOOS) were completed at preoperative and 6 weeks post op.

Results

Preliminary results of 32 participants convey the positive outcomes after total knee replacement demonstrated by the improvement in Oxford Knee Score and Knee Osteoarthritis Outcome score. There are marked improvements in the 2-minute walk tests at the six week time-point. At day one post-operative only 5 participants were unable to walk. Patient-controlled analgesia was used on 5 occasions on day one, 2 of which continued on day two. Sedation scores were recorded in six participants on day one and 2 on day two. Nausea was reported in 5 cases on day one and 9 on day two. Urinary catheter was needed in 5 cases on day one.

Importantly the study remains blinded, therefore an analysis of the three study arms is not available and is therefore currently difficult to report on the statistical significance. There will be further assessment of the efficacy of analgesia using VAS pain scores, analgesia consumption and side effects collected preoperatively, 0–24hrs and 24–48 hours postoperatively between the three randomized groups. The assessment of functional outcomes will be measured between the three groups by comparing the ability to mobilize the first 4 hrs after surgery, maximal flexion and extension, two minute walk test and timed up-and-go preoperatively, on postoperative day 1 and 2 and 6 weeks.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 13 - 13
1 Jan 2016
Grosser D Benveniste S Bramwell D Krishnan J
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Background

Radiostereometric Analysis (RSA) is an accurate measure of implant migration following total joint replacement surgery. Early implant migration predicts later loosening and implant failure, with RSA a proven short-term predictor of long-term survivorship. The proximal migration of an acetabular cup has been demonstrated to be a surrogate measure of component loosening and the associated risk of revision. RSA was used to assess migration of the R3 acetabular component which utilises an enhanced porous ingrowth surface. Migration of the R3 acetabular component was also assessed when comparing the fixation technique of the femoral stems implanted.

Methods

Twenty patients undergoing primary total hip arthroplasty were implanted with the R3 acetabular cup. The median age was 70 years (range, 53–87 years). During surgery tantalum markers were inserted into the acetabulum and the outer rim of the polyliner. RSA examinations were performed postoperatively at 4 to 5 days, 6, 12 and 24 months. Data was analysed for fourteen patients to determine the migration of the acetabular cup relative to the acetabulum. Of these fourteen patients, six were implanted with a cementless femoral stem and eight with a cemented femoral stem. Patients were clinically assessed using the Harris Hip Score (HHS) and Hip Disability and Osteoarthritis Outcome Score (HOOS) preoperatively and at 6, 12 and 24 months postoperatively.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 26 - 26
1 Jan 2016
Stevens A Hussenbocus S Wilson C Mercer G Krishnan J
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Introduction

Total hip replacement (THR) is a very common procedure performed for the treatment of osteoarthritis of the hip. The aim of THR is to restore function and quality of life of the patients, by restoring femoral offset, leg length, centre of rotation, and achieving stability, to avoid dislocation postoperatively.

Method

We aimed to perform preoperative assessment of femoral offset on anteroposterior (AP) radiographs of the hip, and on corresponding CT scans, for patients undergoing primary THR. Patients were positioned according to a standardised protocol prior to obtaining radiographs of the hip and CT scan. Inter- and intra-observer reliability was evaluated between 3 observers of differing levels of seniority – an orthopaedic trainee, a fellow, and a consultant. CT scan measurements of offset were performed by one consultant radiologist. The researchers measuring radiographic offset were blinded to the results of the CT measurements.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 132 - 132
1 Jan 2016
Watts A Williams B Krishnan J Wilson C
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Background

Shoulder impingement syndrome (SIS) is a common debilitating condition, treated across multiple health disciplines including Orthopaedics, Physiotherapy, and Rheumatology. There is little consistency in diagnostic criteria with ‘Shoulder impingement syndrome’ being used for a broad spectrum of complex pathologies. We assessed patterns in diagnostic procedures for SIS across multiple disciplines.

Methods

This is a systematic review of electronic databases MEDLINE, PubMed, The Cochrane Library, Embase, Scopus and CINAHL five years of publications, January 2009 - January 2014. Search terms for SIS included subacromial impingement syndrome, subacromial bursitis. Searches were delimited to articles written in English. The PRISMA guidelines were followed. Two reviewers independently screened all articles, data was then extracted by one reviewer and twenty percent of the extraction was independently assessed by the co-reviewer. Studies included were intervention studies examining individuals diagnosed with SIS and we were interested in the process and method used for the diagnosis.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 27 - 27
1 Jan 2016
Stevens A Wilson C Mercer G Krishnan J
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Introduction

There are conflicting views when assessing the best imaging modality by which to assess long leg alignment pre and post operatively for patients’ receiving primary total hip replacements. It has been a long standing standard that long-leg radiographs are used for measuring and interpreting alignment of the lower limb, but recently it has been suggested that CT imaging may be a better option for this assessment.

Methods

Patients awaiting total knee replacement surgeries were invited to participate in this clinical trial. 120 participants’ consented and completed both pre and post-operative long-leg radiographs, and lower limb CT scans. Long leg radiographs were analysed and measured by senior orthopaedic surgeons pre and post-operatively, while CT scans were analysed using the perth protocol method by trained radiologists. Mechanical alignment of the lower limb was calculated using both imaging modalities, the CT “scout” scan was used for the measurement of the mechanical alignment.

Pre-operatively the patients had their imaging performed between 1 year and 1 week pre-operatively, and following surgery their imaging was standardised to 6 months post-operatively. For long leg radiographs, patients were asked to stand with their feet shoulder width apart and toes forward facing (on occasion deformities would not allow for this stance, and they were asked to adopt this stance to the best of their ability).


The Bone & Joint Journal
Vol. 98-B, Issue 1 | Pages 65 - 74
1 Jan 2016
Phadnis J Huang T Watts A Krishnan J Bain GI

Aims

To date, there is insufficient evidence available to compare the outcome of cemented and uncemented fixation of the humeral stem in reverse shoulder arthroplasty (RSA).

Methods

A systemic review comprising 41 clinical studies was performed to compare the functional outcome and rate of complications of cemented and uncemented stems in RSA. These included 1455 cemented and 329 uncemented shoulders. The clinical characteristics of the two groups were similar.

Variables were compared using pooled frequency-weighted means and relative risk ratios (RR).


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 130 - 130
1 Jan 2016
Wilson C Stevens A Mercer G Krishnan J
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Alignment and soft tissue balance are two of the most important factors that influence early and long term outcome of total knee arthroplasty.

Current clinical practice involves the use of plain radiographs for preoperative planning and conventional instrumentation for intra operative alignment.

The aim of this study is to assess the SignatureTM Personalised system using patient specific guides developed from MRI. The SignatureTM system is used with the VanguardRComplete Knee System. This system is compared with conventional instrumentation and computer assisted navigation with the Vanguard system.

Patients were randomised into 3 groups of 50 to either Conventional Instumented Knee, Computer Navigation Assisted Knee Arthroplasty or Signature Personalised Knee Arthoplasty. All patients had the Vanguard Total knee Arthroplasty Implanted.

All patients underwent Long leg X-rays and CT Scans to measure Alignment at pre-op and 6 months post-op. All patients had clinical review and the Knee Society Score (KSS) at 1 year post surgery was used to measure the outcome.

A complete dataset was obtained for 124 patients. There were significant differences in alignment on Long leg films ot of CT scan with perth protocol. Notably the Signature group had the smallest spread of outliers.

In conclusion the Signature knee system compares well in comparison with traditional instrumentation and CAS Total Knee Arthroplasty.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 14 - 14
1 Jan 2016
Grosser D Mercer G Wilson C Nilsson K Krishnan J
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Background

Safety and efficacy of novel prostheses relies on the determination of early implant migration and subsequent risk of loosening. Radiostereometric Analysis (RSA) has been used to evaluate the clinical failure risks of femoral stems by reporting distal migration, a measure of stem subsidence, when examining early migration characteristics. The migratory patterns of femoral stems, 24 months postoperatively, have provided a surrogate outcome measure to determine implant stabilisation and predict long-term performance and survivorship. RSA assessed femoral stem migration and provided comparison of the early migration characteristics with published data of a clinically established counterpart.

Methods

Twenty five patients undergoing primary total hip arthroplasty were implanted with a hydroxyapatite-coated femoral stem. The median age was 65 years (range, 43–75 years). During surgery tantalum markers were attached onto the distal tip and shoulder of the stem. Eight tantalum markers were inserted into the femur, four placed in each of the greater and lesser trochanter. RSA examinations were performed postoperatively at 4 to 5 days, 6, 12 and 24 months. Eleven patients who had complete RSA follow-up as well as the valid data from five patients were analysed to determine the movement of the femoral stem relative to the femur and were compared to the published data of a clinically established counterpart.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 25 - 25
1 Jan 2016
Stevens A Wilson C Shunmugam M Ranawat V Krishnan J
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Inter- and intra-observer variation has been noted in the analysis of radiographic examinations with regard to experience of surgeons, and the monitors used for conducting the evaluations. The aim of this study is to evaluate inter/intra observer variation in the measurement of mechanical alignment from long-leg radiographs.

40 patients from the elective waiting list for TKA underwent long leg radiographs pre-operatively and 6 months post-operatively (total of 80 radiographs). The x-rays were analysed by 5 observers ranging in experience from medical student to head orthopaedic surgeon. Two observers re-analysed their results 6 months later to determine intraobserver correlation, and one observer re-measured the alignment on a different monitor. These measurements were all conducted blindly and none of the observers had access to the others’ results.

80 radiographs were analysed in total, 40 pre-op and 40 post-op. The mechanical alignment was analysed using Pearson's correlation (r = 0 no agreement, r = 1 perfect agreement) and revealed that experience as an orthopaedic surgeon has little effect on the measurement of mechanical alignment from long leg radiograph. The results for the different monitor analysis were also analysed using Pearson's correlation of long leg alignment. Monitor quality does seem to affect the correlation between alignment measurements when reviewing both intra and inter observer correlation on different computer monitors.

Surgical experience has little impact on the measurement of alignment on long leg radiographs. Of greater concern is that monitors of different resolution can affect measurement of mechanical alignment. As there might be a range of monitors in use in different institutions, and also in outpatient clinics to surgical theatres, close attention should be paid to the implications of these results.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 37 - 37
1 Jan 2016
Stevens A Surabhi R Jaarsma R Bramwell D Krishnan J
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Introduction & aims

Different racial groups show variations in femoral morphometry. Femoral anteroposterior measurement and mediolateral measurement are key variables in designing femoral implant for TKR. Their aspect ratio determines the shape and mediolateral sizing for the proper patellofemoral tracking and uniform stress distribution over the resected distal femoral surface.

Method

We reviewed the current literature in December 2013 in common medical databases including the Cochrane Library, PubMed and Medline. Keywords included combinations of: Anthropometry, Knee, Arthroplasty, Femur, Morphometry, Geometry. We selected papers including femoral morphometric data collected from populations of different ethnic origins. Papers covered populations in the USA, China, Germany, Thailand, Korea, India, Japan and Malaysia.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 208 - 208
1 Mar 2010
Sood A Wallwork N Moss V Pascoe M Krishnan J
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Introduction: Mismatch between patient load and out-patient clinic resources in South Australian public sector has resulted in a long waiting list for initial appointment of new patients with shoulder complaints. There is no validated triage tool to help prioritize the patient referrals appropriately, to avoid inappropriate delays.

Methods: We devised a self evaluation questionnaire to appropriately triage new referrals with shoulder complaints. Ethics committee approval was obtained. Forty eight new referrals to shoulder clinic filled in this questionnaire and the self evaluation part of American Shoulder and Elbow Society form. The patients were assessed in chronological order by two surgeons. Both were blinded to the GP referral and questionnaire findings at the time of patient assessment. GP referrals and the questionnaires were subsequently assessed and triaged. These findings were compared to assessment in the clinic.

Results: Whilst the questionnaire provided significantly more information when compared to GP referrals, both were inadequate on their own as reliable triage tool. However in combination, majority of the patients could be triaged appropriately. Based on the presumptive diagnosis, basic investigations and therapy can be correctly instituted whilst awaiting formal orthopaedic review. None of the patients would have been allocated a lower priority than appropriate. The self evaluation part of ASES form on its own was not a satisfactory tool for triaging.

Discussion: The proposed questionnaire and initial referral letter can be used for safe triaging and ensuring most basic relevant clinical workup is done prior to presentation. Further refinement of the questionnaire and additional studies are required to fully define its role in routine public hospital use.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 27 - 28
1 Jan 2003
Walker R Wigg A Krishnan J Slavotinek J
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External fixation of distal radius fractures usually involves the use of a bridging fixator. However, immobilisation of the wrist can be associated with various complications and therefore dynamic external fixators were developed to allow wrist mobilisation with the fixator in place. But dynamic fixators themselves are not without complications and more recently interest has been rekindled in non-bridging external fixators (otherwise called metaphyseal or radial-radial fixators).

Following a pilot study using a non-bridging external fixator (Delta frame) in the treatment of intra-articular distal radius fractures, our aim in this study was to compare the functional and radiological outcome of the Delta frame and a standard wrist-bridging static external fixator in the treatment of such fractures. Sixty patients with intra-articular distal radius fractures were randomly allocated to receive either a static bridging Hoffman external fixator or a non-bridging Delta frame. All patients had the fixator removed at six weeks. Clinical and radiographic assessment was performed regularly up to a maximum of twelve months with the clinical results being expressed in terms of range of movement, pain, grip strength and ability to perform certain activities of daily living. Radiological assessment was performed by an independent radiologist. Mean follow-up was ten months.

The only sustained significant difference in function was a greater range of flexion in the Hoffman group. No significant difference could be detected between the two groups in terms of the radiological outcome. Complications included pin-site infection, paraesthesia, extensor pollicis longus tendon rupture and chronic regional pain syndrome. Three patients underwent further surgery. We did not demonstrate any advantage in the use of a non-bridging fixator in the treatment of intra-articular distal radius fractures.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 224 - 224
1 Nov 2002
van Essen J Costi J Hearn T Krishnan J
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Purpose: A variety of second generation femoral interlocking intramedullary nails, in which the proximal lag screw is engaged in the femoral head, are now available for the treatment of complex comminuted pertrochanteric femoral fractures. Jamming of the lag screw results in a rigid device which is more likely to cut-out of the femoral head. The aim of this study was to determine the sliding characteristics and jamming potential of the lag screws of five different devices used to treat these fractures.

Method: The devices examined include; the single lag screw devices: the DHS, the Gamma nail and the Intramedullary hip screw (IMHS), and the double lag screw devices: the Russell-Taylor Reconstruction nail (RTN) and the Austofix Hip nail. The devices were mounted in a servo-hydraulic testing apparatus and examined by two different techniques. The first set-up looked at lag screw motion with respect to loads applied which were representative of the single limb stance phase of gait (SLSPOG). The second set-up which, was first described by Kyle in 1980, looked at the forces required to initiate sliding.

Results: For the first set up (SLSPOG), all single lag screw devices demonstrated sliding across the normal physiological range of applied load. The Russell Taylor Reconstruction nails demonstrated conflicting results with the lag screws of two nails sliding and one nail jamming. All the Austofix nails jammed at the higher angles of the normal physiological range (1590, 1640).

Using the Kyle set-up, the forces required to initiate sliding were found to be lowest with the Synthes DHS (42.33±5.77N), Zimmer CHS (52.67±26.56N), and the IMHS (45.33±10.97N). These were closely followed by the Gamma nail (79.33±8.39N) and the Richards Classic hip screw (82.00±16.37N). The highest forces were for the RTN (98.00±18.52N) and the Austofix hip nail (283.00±70.62N). These results were significantly different. (p< 0.001, ANOVA)

Conclusion: The results demonstrate that double lag screw implants require greater loads to initiate sliding and have a greater potential for jamming. Whilst all single lag screw nails slide, barrel length does alter the forces required to initiate sliding. Further testing using a lubricant is currently being undertaken.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 214 - 214
1 Nov 2002
Wigg A Walker R Krishnan J
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Introduction: Current fixation methods for distal radial fractures usually involve immobilisation, which has been suggested to have adverse effects on wrist function. The aims of this study were to compare the clinical, functional and radiological outcomes of a bridging, and a non-bridging external fixator that did not cross the wrist joint, in the management of intra-articular fractures of the distal radius.

Methods: Sixty subjects were randomly allocated to receive a bridging Hoffman frame and limited wrist range of movement (ROM) exercises for 6 weeks, or a non-bridging Delta frame and full active wrist ROM exercises commencing at 2 weeks. All frames were removed at 6 weeks. Radiographic and clinical assessments were made at regular postoperative time intervals for 12 months with clinical outcomes including measures of pain, ROM, grip strength, function and quality of life.

Results: Preliminary clinical results analysing pain, grip strength and ROM including flexion, extension, pronation and supination at 1–6, 26 and 52 weeks postoperatively indicated that no statistically significant difference could be detected between the two groups at any time frame. Complication rates were similar for both groups. Preliminary radiographic analysis of dorsal angle, radial angle and radial length at 6, 26 and 52 weeks postoperatively also indicated that no statistically significant difference could be detected between the two groups.

Conclusion: Preliminary results of this trial suggest that no difference can be detected in the clinical and radiographic outcomes of subjects receiving a bridging external fixator with limited early wrist ROM exercises, or a non-bridging external fixator with early full active ROM exercises in the management of intra-articular fractures of the distal radius.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 262 - 262
1 Nov 2002
Stavrou P Slavotinek J Krishnan J
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The concept of bipolar hemiarthroplasty has been described in the hip for over twenty years, its role being to decrease acetabular wear. Shoulder bipolar hemiarthroplasty is a more recent concept. The purpose of this study was to determine if the prostheses acted as a bipolar device, moving primarily at the inner metal on polyethylene bearing as intended or as a unipolar hemiarthroplasty moving at the outer metal on cartilage surface.

Eleven bipolar shoulder hemiarthroplasties with a minimum follow up of twenty two months were examined fluoroscopically. The proportion of arm abduction occurring in the scapulothoracic plane as well as that between the two components of the bipolar hemiarthroplasty was assessed and compared to that of normal patients and those with total shoulder replacements, previously reported in the literature.

The results of this study show that the majority of movement occurring in active arm abduction occurred in the scapulothoracic plane and that the bipolar hemiarthroplasty acted predominantly as a unipolar device.