At the Zorab Symposium in Oxford, 2006, we showed that semicircular canal (SCC) anomalies occurring with posterior basicranium asymmetry affect the oculovestibular system in human beings. As a consequence, we proposed the hypothesis of a descending direct vestibulospinal and cognitive top-down effect on some scoliosis. We will show that some SCC anomalies detected with MRI modelling are malformations frequently found in scoliosis. 445 patients (323 women, mean age 21 years; 122 men, mean age 24 years) with instability, imbalance, and spatial disorientation were submitted to T2 MRI modelling. 95 of 445 patients had scoliosis: 57 thoracolumbar scoliosis, 24 thoracic scoliosis, and 14 lumbar deformation. We processed the data acquired with G.E.MRI (1.5T), T2- 3D Fiesta with a set of Brainvisa modules (http://brainvisa.info/).Introduction
Methods
Control group (CG):32 subjects, 26W. &
6M., fr. 8 to 51. AIS group (AISG):93 subjects, 77W. &
16M., fr. 6 to 63. AIS were classified according to – Amplitude of spine deformation (d°) G1: 8 to10°, G2: 10 to 15°, G3:15 to 40° – Location of deformation (Ponsetti class.): TL=thoracolumbar, T=thoracic, L=lumbar.
Step1: 3D Basicranium measurements in both groups with Brainvisa processing: ( Step2: 3D anatomical study of semicircular canals in both groups with original modelling software.
AIS showed a pathognomic increase of these Human traits. Inside AIS subgroups, TL &
G3 revealed highest levels of asymmetry and rotation. We will discuss, thanks to AIS homozygosis twins in mirror, genetic origins for these specific P.B. &
Cerebellum asymmetries. Modelling of semi-circular canals revealed significative malformations in AIS compared to normal group. Again, T.L. and G3 revealed highest scores of canals anomalies. We highlighted a specific malformation in AIS: abnormal connexion between lateral &
posterior canal. We will demonstrate, thanks to same AIS twins, genetic origins of this malformation and propose a genetic hypothesis to link the different results.
