Advertisement for orthosearch.org.uk
Results 1 - 2 of 2
Results per page:
Applied filters
Include Proceedings
Dates
Year From

Year To
Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 286 - 286
1 Jul 2014
Lee J Jeong C
Full Access

Summary Statement

The implantation of scaffold-free CTE from suspension culture into growth-plate defects resulted in a significant reduction in growth arrest of the rabbit tibia

Introduction

In childhood and adolescence, the growth plate injury can cause partial premature arrest of growth plate, which can make problems such as leg length discrepancy and angular deformity. Bone bridge resection and variable implantation materials such as fat, bone wax, silastic and craniopalst has been investigated. However, those procedures may show limitations including the control of bone growth and long term safety of implant materials in vivo. As an alternative, homogeneous or heterogeneous cartilage cells and stem cell transplants have been tried. In this method, scaffold for cell transplantation is needed. But, so far the most suitable scaffold has not been established. Recently, some authors generated a cartilage tissue equivalent (CTE) using a suspension culture with biophysical properties similar to native hyaline cartilage. Therefore we are able to transplant the CTE without scaffold to the physeal defect. The purpose of this study was to investigated the effects of a transplantation of a vitro-generated scaffold-free tissue-engineered cartilage tissue equivalent (CTE) using a suspension chondrocyte culture in a rabbit growth arrest model.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 149 - 149
1 Feb 2004
Kim H Lee K Jeong C Moon C Kim Y
Full Access

Introduction: It is very important to evaluate the healing process in the femoral head after free vascularized fibular graft (VFG) in osteonecrosis of the femoral head (ONFH). Bone scintigraphy combined with a pinhole collimator, which is simple and not expensive, is used for very high resolution images of small organs, such as thyroid and certain skeletal regions. The purpose of this study was to assess the changes using pinhole bone scintigraphy in ONFH after VFG.

Materials and Methods: Changes of Tc-99m-HDP pinhole bone scintigraphy were analyzed in 22 cases of ONFH which were treated with VFG and had satisfactory results in patient evaluations at least 2 years after surgery. Harris Hip Scores were 90 points or more; and femoral head collapse was less than 2 mm.

Results: The results were: (1) At 1 week, the pinhole image showed no significant change in cold area but two linear RI uptakes corresponding to the fibular graft were noted. (2) At 3 months, localized hot uptakes just above the tip of the graft were observed in 17 cases (77.2%), and diffuse increased uptake surrounding the cold area were observed. (3) At 6 months, localized hot uptake were increased in size and replaced cold areas and delineated the shape of the superolateral aspect of the femoral head. (4) At 1 year, increased RI uptake of the superolateral aspect of the femoral head expanded medially in all cases. (5) After 2 years, cold areas faded away in 18 cases (81.8%).

Discussion: In conclusion, the authors believe that the Tc-99m-HDP pinhole bone scintigraphy is an excellent method to delineate the healing process in ONFH after VFG.