Background

Smoking has been associated with poor tissue oxygenation and vascularisation, predisposing smokers to a higher risk for postsurgical infections. The aim of this study was to estimate and compare the incidence of prosthetic joint infection (PJI) following primary total joint arthroplasty (TJA) according to smoking status.

Large-head metal-on-metal (MoM) total hip replacements (THR) have given rise to concern. Comparative studies of small-head MoM THRs over a longer follow-up period are lacking. Our objective was to compare the incidence of complications such as infection, dislocation, revision, adverse local tissue reactions, mortality and radiological and clinical outcomes in small-head (28 mm) MoM and ceramic-on-polyethylene (CoP) THRs up to 12 years post-operatively.

A prospective cohort study included 3341 THRs in 2714 patients. The mean age was 69.1 years (range 24 to 98) and 1848 (55.3%) were performed in women, with a mean follow-up of 115 months (18 to 201). There were 883 MoM and 2458 CoP bearings. Crude incidence rates (cases/1000 person-years) were: infection 1.3 vs 0.8; dislocation 3.3 vs 3.1 and all-cause revision 4.3 vs 2.2, respectively. There was a significantly higher revision rate after ten years (adjusted hazard ratio 9.4; 95% CI 2.6 to 33.6) in the MoM group, and ten of 26 patients presented with an adverse local tissue reaction at revision. No differences in mortality, osteolysis or clinical outcome were seen.

In conclusion, we found similar results for small-head MoM and CoP bearings up to ten years post-operatively, but after ten years MoM THRs had a higher risk of all-cause revision. Furthermore, the presence of an adverse response to metal debris seen in the small-head MOM group at revision is a cause for concern.

Cite this article: Bone Joint J 2014; 96-B:868–75.

The maintenance of quality and integrity in clinical and basic science research depends upon peer review. This process has stood the test of time and has evolved to meet increasing work loads, and ways of detecting fraud in the scientific community. However, in the 21st century, the emphasis on evidence-based medicine and good science has placed pressure on the ways in which the peer review system is used by most journals.

This paper reviews the peer review system and the problems it faces in the digital age, and proposes possible solutions.

Cite this article: Bone Joint J 2014;96-B:436–41.

Whether patients with asymptomatic bacteriuria should be investigated and treated before elective hip and knee replacement is controversial, although it is a widespread practice. We conducted a prospective observational cohort study with urine analyses before surgery and three days post-operatively. Patients with symptomatic urinary infections or an indwelling catheter were excluded. Post-discharge surveillance included questionnaires to patients and general practitioners at three months. Among 510 patients (309 women and 201 men), with a median age of 69 years (16 to 97) undergoing lower limb joint replacements (290 hips and 220 knees), 182 (36%) had pre-operative asymptomatic bacteriuria, mostly due to Escherichia coli, and 181 (35%) had white cells in the urine. Most patients (95%) received a single intravenous peri-operative dose (1.5 g) of cefuroxime as prophylaxis. On the third post-operative day urinary analysis identified white cells in 99 samples (19%) and bacteriuria in 208 (41%). Pathogens in the cultures on the third post-operative day were different from those in the pre-operative samples in 260 patients (51%). Only 25 patients (5%) developed a symptomatic urinary infection during their stay or in a subsequent three-month follow-up period, and two thirds of organisms identified were unrelated to those found during the admission. All symptomatic infections were successfully treated with oral antibiotics with no perceived effect on the joint replacement.

We conclude that testing and treating asymptomatic urinary tract colonisation before joint replacement is unnecessary.

Cite this article: Bone Joint J 2014;96-B:390–4.

Introduction

Conventional pre-operative planning for total hip arthroplasty mostly relies on the patient radiologic anatomy for the positioning and choice of implants. This kind of planning essentially remains a static approach since dynamic aspects such as the joint kinematics are not taken into account. Hence, clinicians are not able to fully consider the evolving behavior of the prosthetic joint that may lead to implant failures. In fact, kinematics plays an important role since some movement may create conflicts within the prosthetic joint and even provoke dislocations. The goal of our study was to assess the relationship between acetabular implant positioning variations and resultant impingements and loss of joint congruence during daily activities. In order to obtain accurate hip joint kinematics for simulation, we performed an in-vivo study using optical motion capture and magnetic resonance imaging (MRI).

Introduction

Today, there is no clear consensus as to the amplitude of movement of the “normal hip”. Knowing the necessary joint mobility for everyday life is important to understand different pathologies and to better plan their treatments. Moreover, determining the hip range of motion (ROM) is one of the key points of its clinical examination. Unfortunately this process may lack precision because of movement of other joints around the pelvis. Our goal was to perform a preliminary study based on the coupling of MRI and optical motion capture to define precisely the necessary hip joint mobility for everyday tasks and to assess the accuracy of the hip ROM clinical exam.

We undertook a retrospective case-control study to assess the clinical variables associated with infections in open fractures. A total of 1492 open fractures were retrieved; these were Gustilo and Anderson grade I in 663 (44.4%), grade II in 370 (24.8%), grade III in 310 (20.8%) and unclassifiable in 149 (10.0%). The median duration of prophylaxis was three days (interquartile range (IQR) 1 to 3), and the median number of surgical interventions was two (1 to 9). We identified 54 infections (3.6%) occurring at a median of ten days (IQR 5 to 20) after trauma. Pathogens intrinsically resistant to the empirical antibiotic regimen used (enterococci, Enterobacter spp, Pseudomonas spp) were documented in 35 of 49 cases (71%). In multivariable regression analyses, grade III fractures and vascular injury or compartment syndrome were significantly associated with infection. Overall, compared with one day of antibiotic treatment, two to three days (odds ratio (OR) 0.6 (95% confidence interval (CI) 0.2 to 2.0)), four to five days (OR 1.2 (95% CI 0.3 to 4.9)), or > five days (OR 1.4 (95% CI 0.4 to 4.4)) did not show any significant differences in the infection risk. These results were similar when multivariable analysis was performed for grade III fractures only (OR 0.3 (95% CI 0.1 to 3.4); OR 0.6 (95% CI 0.2 to 2.1); and OR 1.7 (95% CI 0.5 to 6.2), respectively).

Infection in open fractures is related to the extent of tissue damage but not to the duration of prophylactic antibiotic therapy. Even for grade III fractures, a one-day course of prophylactic antibiotics might be as effective as prolonged prophylaxis.

Cite this article: Bone Joint J 2013;95-B:831–7.

There are no recent studies comparing cable with wire for the fixation of osteotomies or fractures in total hip replacement (THR). Our objective was to evaluate the five-year clinical and radiological outcomes and complication rates of the two techniques. We undertook a review including all primary and revision THRs performed in one hospital between 1996 and 2005 using cable or wire fixation. Clinical and radiological evaluation was performed five years post-operatively. Cables were used in 51 THRs and wires in 126, and of these, 36 THRs with cable (71%) and 101 with wire (80%) were evaluated at follow-up. The five-year radiographs available for 33 cable and 91 wire THRs revealed rates of breakage of fixation of 12 of 33 (36%) and 42 of 91 (46%), respectively. With cable there was a significantly higher risk of metal debris (68% vs 9%; adjusted relative risk (RR) 6.6; 95% confidence interval (CI) 3.0 to 14.1), nonunion (36% vs 21%; adjusted RR 2.0; 95% CI 1.0 to 3.9) and osteolysis around the material, acetabulum or femur (61% vs 19%; adjusted RR 3.9; 95% CI 2.3 to 6.5). Cable breakage increased the risk of osteolysis to 83%. There was a trend towards foreign-body reaction and increased infection with cables. Clinical results did not differ between the groups.

In conclusion, we found a higher incidence of complications and a trend towards increased infection and foreign-body reaction with the use of cables.

In foot and ankle surgery incorrect placement of implants, or inaccuracy in fracture reduction may remain undiscovered with the use of conventional C-arm fluoroscopy. These imperfections are often only recognized on postoperative computer tomography scans. The apparition of three dimensional (3D) mobile Imaging system has allowed to provide an intraoperative control of fracture reduction and implant placement. Three dimensional computer assisted surgery (CAS) has proven to improve accuracy in spine and pelvic surgery. We hypothesized that 3D-based CAS could improve accuracy in foot and ankle surgery.

The purpose of our study was to evaluate the feasibility and utility of a multi-dimensional surgical imaging platform with intra-operative three dimensional imaging and/or CAS in a broad array of foot and ankle traumatic and orthopaedic surgery.

Cohort study of patients where the 3D mobile imaging system was used for intraoperative 3D imaging or 3D-based CAS in foot and ankle surgery.

The imaging system used was the O-arm Surgical Imaging System and the navigation system was the Medtronic's StealthStation.

Surgical procedures were performed according to standard protocols.

In case of fractures, image acquisition was performed after reduction of the fracture. In cases of 3D-based CAS, image acquisition was performed at the surgical step before implants placement. At the end of the operations, an intraoperative 3D scan was made.

We used the O-arm Surgical Imaging system in 11 patients: intraoperative 3D scans were performed in 3 cases of percutaneus fixation of distal tibio-fibular syndesmotic disruptions; in 2 of the cases, revision of reduction and/or implant placement were needed after the intraoperative 3D scan.

Three dimensional CAS was used in 10 cases: 2 open reduction and internal fixation (ORIF) of the calcaneum, 1 subtalar fusion, 2 ankle arthrodesis, 1 retrograde drilling of an osteochondral lesion of the talus, 1 Charcot diabetic reconstruction foot and 1 intramedullary screw fixation of a fifth metatarsal fracture. The guidance was used essentially for screw placement, except in the retrograde drilling of an osteochondral lesion where the guidance was used to navigate the drill tool. Intraoperative 3D imaging showed a good accuracy in implant placement with no need to revision of implants.

We report a preliminary case series with use of the O-arm Surgical Imaging System in the field of foot and ankle surgery. This system has been used either as intraoperative 3D imaging control or for 3D-based CAS. In our series, the 3D computer assisted navigation has been very useful in the placement of implants and has shown that guidance of implants is feasible in foot and ankle surgery. Intraoperative 3D imaging could confirm the accuracy of the system as no revisions were needed. Using the O-arm as intraoperative 3D imaging was also beneficial because it allowed todemonstrate intraoperative malreduction or malposition of implants (which were repositioned immediately). Intraoperative 3D imaging system showed very promising preliminary results in foot and ankle surgery. There is no doubt that intraoperative use of 3D imaging will become a standard of care. The exact indications need however to be defined with further studies.

Introduction

Currently, a validate scale of ankle osteoarthritis (OA) is not available and different classifications have been used, making comparisons between studies difficult. In other joints as the hip and knee, the Kellgren-Lawrence (K&L) scale, chosen as reference by the World Health Organizations is widely used to characterize OA. It consists of a physician based assessment of 3 radiological features: osteophyte formation, joint space narrowing and bone end sclerosis described as follows: grade 0: normal joint; grade 1: minute osteophytes of doubtfull significance; grade 2: definite osteophytes; grade 3: moderate diminution of joint space; grade 4: joint space greatly impaired, subchondral sclerosis. Until now, the K&L scale has never been validated in the ankle. Our objective was to assess the usefulness of the K&L scale for the ankle joint, by determining its reliability and by comparing it to functional scores and to computerized minimal joint space width (minJSW) and sclerosis measurements. Additionally we propose an atlas of standardized radiographs for each of the K&L grades in the ankle.

Introduction

Among patients with ankle osteoarthritis (OA) a post-traumatic origin is much more frequent than among those with knee or hip OA. However, long-term studies evaluating risk factors for the development of OA after ankle fractures are lacking.

Introduction

A recent review of the literature on metal-on-metal total hip arthroplasties (THA) revealed the lack of comparative clinical studies with a sufficient sample size and the inclusion of patient-reported outcomes as well as patient activity levels.

Introduction

Large diameter metal on metal cups have been used in total hip arthroplasty advocating superior results with respect to dislocation rates, range of motion and long term survival. The Durom cup used as part of the Durom hip resurfacing system has been incriminated with poor short term results sometimes correlated to incorrect positioning of either the femoral or acetabular component. Our objective was to evaluate short term results of the Durom cup used in conjunction with standard stems.

Introduction

Orthopaedic surgeons are frequently asked to perform a revision total hip arthroplasty (THA) in patients over 80 years of age. Our objective was to evaluate the outcomes after revision THA in patients 80 years or older and compare them to a cohort of patients less than 80 years of age.

Purpose of the study: Stiffness of the ankle joint is a common complication after fracture, surgical repair, or total ankle arthroplasty. Dorsiflexion is generally the most limited movement. A few older papers have focused on this common problem in orthopaedic surgery of the ankle joint but have been controversial. The purpose of this anatomy study was to evaluate the efficacy and quantify the impact of releasing the collateral ligaments of the ankle joint on dorsiflexion stiffness.

Material and methods: The two main ankle ligaments implicated in this type of stiffness, the deep bundle of the posterior tibiotalar ligament (dPTTaL) and the posterior talofibular ligament (PTaFL), were studied. We dissected 16 talocrural joints on fresh cadavers and measured with electronic goniometry coupled with electronic dynamometry their movement in dorsiflexion after section of the dPTTaL in the first group and after section of the PTaFL in the second.

Results: The results showed a significant difference (p< 0.0003) between the two populations of ankles. Section of the dPTTaL was more effective against dorsiflexion stiffness than section of the PTaFL, even though the overall benefit in dorsiflexion was less than 10° (mean 7.45 versus 3.45). Combined section of the two ligaments did not provide a statistically significant improvement in the gain in dorsiflextion (p=0.88) compared with isolated section of the two ligaments.

Discussion: If limitation of active and passive dorsiflexion persists after classical release or lengthening of the posterior periarticular tendons of the ankle joint, or after gastrocnemius lengthening, our results show that the following surgical step could be meticulous release of the dPTTaL.

Purpose: We aimed to provide an anatomical basis for surgical techniques in rotator cuff reinsertion. The purpose of this study was to investigate the 3-dimensional trabecular bone mineral density (BMD) in the humeral head bone and determine areas of low density. Limited information exists for humeral head to understand its mechanical behaviour.

Materials and Methods: 15 unpaired fresh humeral heads were harvested and frozen. The mean age was 75 years old. All abnormal bones underlying fractures, major arthrosis or surgical interventions were excluded from the study All the heads were scanned using a three-dimensional HR-pQCT system providing 80 microns slices nominal resolution. Manually outlining of the contours of cancellous bone was done in different areas: lesser tuberosity, greater tuberosity, articular part and centre. The parameters included in the analysis were: bone volume density (BV/TV, Trabecular thickness (tb.Th)(mm), Trabecularseparation(TB.Sp)(mm), Trabecular number(TB.N. (1/mm)

Results: The average density of the lesser tuberosity is the highest of the whole head (BV/TV= 0,228). The centre of the head is devoided of large trabeculae with a very low density (BV/TV =0,1). The greater tuberosity is rich in thin trabeculae (Tb Th = 0,265) separated by large spaces (1,5). The articular part presents the higher density (BV/TV =0,3).

Conclusions: Emphasis has traditionally been placed on cortical bone as quality predictor due to its stiffness for achieving primary stabilisation. However screws and anchors are mainly in contact with cancellous part of bone, and mechanical characteristics of cancellous bone also influence the load-bearing capacity of implant –bone union This studies is interesting in showing areas of poor cancellous bone quality and may help to improve surgical techniques.

Background: Among patients undergoing total hip arthroplasty (THA) 24–36% are obese. The most important long-term complication is periprosthetic osteolysis. While patient activity, implant type and quality of fixation are known risk factors for osteolysis, the literature concerning obesity is sparse and controversial. Our objective was to evaluate the influence of obesity on femoral osteolysis five and ten years after primary THA with a cemented stem.

Methods: Prospective cohort study conducted between 1996 and 2003 among patients undergoing THA (uncemented cup, cemented stem, 28mm head and ceramic-polyethylene bearing surface) inserted with a third generation cementing technique. All patients were seen at either five or ten years, with information regarding BMI and activity, and with radiographic follow-up. BMI was evaluated in three and four categories (< 25, 25–29.9 (reference category), 30–34.9 and ≥35 kg/m²). Activity was assessed using the University of California, Los Angeles (UCLA) activity scale (1–10 points). Main outcome was the radiographic assessment of femoral osteolysis. Secondary outcomes were polyethylene wear and revision for aseptic loosening.

Results: We included 503 THAs in 433 patients. Of those 241 THAs (48%) were seen at five years and 262 (52%) at ten years. Osteolytic lesions were identified in forty-four cases, twenty-four in 181 normal weight patients (13.3%), eleven in 205 overweight (5.4%), seven in ninety-six obese class I (7.3%), and two in twenty-one obese class II patients (9.5%). Activity was highest in normal weight patients (mean UCLA score 5.5, ±2.0) and lowest in patients obese class II (mean UCLA score 4.8, ±1.7). Univariate as well as multivariate logistic regression analysis adjusting for activity, cementing quality, age, and sex did not show an increased risk of osteolysis in obese compared to overweight patients (adjusted OR 1.4, 95% CI 0.6; 3.7). A significantly higher risk was found in normal weight patients (adjusted OR 2.6, 95% CI 1.2; 5.7). Total mean polyethylene wear was significantly lower in obese compared to normal/overweight patients (p=0.024). Revision for aseptic loosening of the stem was necessary in 4 patients (3 normal weight patients and 1 overweight patient).

Conclusions: We did not find an increased risk for femoral osteolysis or revision for aseptic loosening in obese patients five and ten years after primary THA with a cemented stem.

Introduction: An ankle fracture represents the most frequent osseous injury in both the elderly and non-elderly population. To date, only a limited number of retrospective studies have addressed medium-term outcome following ankle Open Reduction and Internal Fixation (ORIF). The purpose of this study was to assess residual pain and functional outcome 10 to 20 years after operative treatment of ankle fractures and to evaluate the incidence of symptomatic and radiographic ankle osteoarthritis (OA).

Methods: We designed a retrospective study including all consecutive patients who underwent ankle ORIF between January 1988 and December 1997 in a University Hospital setting. Pilon and talus fracture as well as pediatric patients were excluded. Patients were seen by two senior residents 10–20 years after their index surgery. Residual pain was measured using the Visual Analog pain Scale. Function and general health status were assessed using the Olerud and Molander Ankle Score, the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score and the 12-item short-form health survey (SF-12). Ankle OA on standard radiographs was scored according to the revised Kellgren and Lawrence (K& L) scale.

Results: 374 patients (56% men) underwent ankle surgery during the defined period. 10% of the patients had a Weber A fracture, 57% a Weber B and 33% a Weber C fracture. Mean age at the time of operation was 42.9 years (+/− 17.1; range 16–86 years). 10–20 years after surgery, 47 patients had died, 126 had left the country and were lost to follow-up, 99 did not respond or refused to participate, and 102 patients were seen at the follow-up visit. These patients did not differ in terms of age, gender distribution, BMI and type of fracture from those who were not seen. The mean duration of follow up was 17.3 years (+/− 3.3). Advanced radiographic OA (K& L grade 3 and 4) was present in 34.3 % of the patients. Symptomatic OA was reported by 34.3 % of the patients (AOFAS pain score < 40). Both clinically symptomatic and radiographic ankle OA was found in 18 patients (17.6%). Function was good in 85% of the cases (total AOFAS hindfoot score between 80 and 100 points; mean total AOFAS hindfoot score 89.9, +/−14.6). The mean Olerud and Molander ankle score was 86.5 (+/−18.7). The general health status (SF-12) was similar to representative values of the general population with a similar mean age.

Conclusion: 10–20 years after operative treatment of an ankle fracture, the incidence of advanced radiographic post-traumatic ankle OA was 35%, symptomatic OA was present in one third of the patients and about one fifth had both. The majority of the patients reported good function.

We conducted a longitudinal study including patients with the same type of primary hybrid total hip replacement and evaluated patient activity and femoral osteolysis at either five or ten years post-operatively. Activity was measured using the University of California, Los Angeles scale. The primary outcome was the radiological assessment of femoral osteolysis. Secondary outcomes were revision of the femoral component for aseptic loosening and the patients’ quality of life. Of 503 hip replacements in 433 patients with a mean age of 67.7 years (30 to 91), 241 (48%) were seen at five and 262 (52%) at ten years post-operatively. Osteolytic lesions were identified in nine of 166 total hip replacements (5.4%) in patients with low activity, 21 of 279 (7.5%) with moderate activity, and 14 of 58 (24.1%) patients with high activity. The risk of osteolysis increased with participation in a greater number of sporting activities. In multivariate logistic regression adjusting for age, gender, body mass index and the inclination angle of the acetabular component, the adjusted odds ratio for osteolysis comparing high vs moderate activity was 3.6 (95% confidence interval 1.6 to 8.3). Stratification for the cementing technique revealed that lower quality cementing increased the effect of high activity on osteolysis. Revision for aseptic loosening was most frequent with high activity. Patients with the highest activity had the best outcome and highest satisfaction.

In conclusion, of patients engaged in high activity, 24% had developed femoral osteolysis five to ten years post-operatively.

Objective: The Morscher press-fit cup is a cementless, porous-coated acetabular component. The objective of this study was to assess clinical and radiological outcomes, patient satisfaction and complications at 10 years.

Methods: Prospective cohort study including all consecutive primary THAs with the Morscher cup operated by multiple surgeons of a University hospital between March 1996 and April 1998. Patients were evaluated at 120 months (±7.2 months) with clinical and radiological follow-up, patient satisfaction and questionnaire assessment, using the Harris Hip Score (HHS), WOMAC and SF-12. Follow-up examination was done by two physicians who had not performed the operations.

Results: 421 THAs were performed in 389 patients (54.6% women; mean age 69.3, range 28–98). In 80% the diagnosis was primary osteoarthritis. All stems were cemented except for 18 patients (4.3%). One-hundred-twenty-two patients (29.0%) had died, 27 (6.4%) were lost-to follow-up, 24 (5.7%) were unable to attend because of poor general health and 27 (6.4%) refused, thus leaving 221 hips, for which 176 x-rays were available.

None of the patients required cup revision for aseptic loosening. Complications included 12 dislocations and 3 deep infections resulting in 2 total revisions. In 3 patients the stem was revised for aseptic loosening at a mean of 63 months. At 10-years the survivorship was 98.6% (95% CI 96.7; 99.4) with endpoint revision for any cause.

Mean total wear was 0.89 mm (±0.5). 32 cups (18.8%) with a cup inclination > 45° had a mean wear of 1.06 mm (±0.5), whereas 138 cups (81.2%) with inclination < 45° had a mean wear of 0.86 mm (±0.5), p=0.036. In 16 cases osteolytic defects around the stem were present. The outcome scores at 10 years were: HHS 85.9 (±14.1), WOMAC pain 70.7 (±24.7), WOMAC function 68.8 (±24.5), SF-12 physical score 40.3 (±9.2) and mental score 47.0 (±10.4). Ninety-four percent of the patients were satisfied or very satisfied.

Conclusions: The Morscher acetabular replacement cup provides excellent results at 10 years. None of the patients had to be revised for aseptic loosening of the cup, patient satisfaction was high, and clinical results were very good.